Search

Your search keyword '"Perugino, Cory"' showing total 221 results
Start Over Author "Perugino, Cory"
221 results on '"Perugino, Cory"'

3. Sex as a predictor of clinical phenotype and determinant of immune response in IgG4-related disease: a retrospective study of patients fulfilling the American College of Rheumatology–European League Against Rheumatism classification criteria

Author

Jha, Isha, McMahon, Grace A, Perugino, Cory A, Katz, Guy, Wallace, Zachary S, Fernandes, Ana, Jiang, Bohang, Zhang, Yuqing, McMahon, Aubree E, Guy, Thomas V, Liu, Hang, Hernandez-Barco, Yasmin G, Pillai, Shiv, and Stone, John H

Published
2024
Full Text
View/download PDF

5. Evaluation of the safety, efficacy, and mechanism of action of obexelimab for the treatment of patients with IgG4-related disease: an open-label, single-arm, single centre, phase 2 pilot trial

Author

Perugino, Cory A, Wallace, Zachary S, Zack, Debra J, Quinn, Shauna M, Poma, Allen, Fernandes, Ana D, Foster, Paul, DeMattos, Steve, Burington, Bart, Liu, Hang, Allard-Chamard, Hugues, Smith, Nathan, Kai, Xin, Xing, Kelly, Pillai, Shiv, and Stone, John H

Published
2023
Full Text
View/download PDF

6. Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

Author

Allard-Chamard, Hugues, Kaneko, Naoki, Bertocchi, Alice, Sun, Na, Boucau, Julie, Kuo, Hsiao-Hsuan, Farmer, Jocelyn R., Perugino, Cory, Mahajan, Vinay S., Murphy, Samuel J.H., Premo, Katherine, Diefenbach, Thomas, Ghebremichael, Musie, Yuen, Grace, Kotta, Alekhya, Akman, Zafer, Lichterfeld, Mathias, Walker, Bruce D., Yu, Xu G., Moriyama, Masafumi, Maehara, Takashi, Nakamura, Seiji, Stone, John H., Padera, Robert F., and Pillai, Shiv

Published
2023
Full Text
View/download PDF

8. IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells

Author

Newman, John H, Shaver, Aaron, Sheehan, Jonathan H, Mallal, Simon, Stone, John H, Pillai, Shiv, Bastarache, Lisa, Riebau, Derek, Allard‐Chamard, Hugues, Stone, William M, Perugino, Cory, Pilkinton, Mark, Smith, Scott A, McDonnell, Wyatt J, Capra, John A, Meiler, Jens, Cogan, Joy, Xing, Kelly, Mahajan, Vinay S, Mattoo, Hamid, Hamid, Rizwan, Phillips, John A, Adams, David R, Aday, Aaron, Alejandro, Mercedes E, Allard, Patrick, Ashley, Euan A, Azamian, Mahshid S, Bacino, Carlos A, Balasubramanyam, Ashok, Barseghyan, Hayk, Batzli, Gabriel F, Beggs, Alan H, Behnam, Babak, Bellen, Hugo J, Bernstein, Jonathan A, Bican, Anna, Bick, David P, Birch, Camille L, Bonner, Devon, Boone, Braden E, Bostwick, Bret L, Briere, Lauren C, Brown, Donna M, Brush, Matthew, Burke, Elizabeth A, Burrage, Lindsay C, Butte, Manish J, Chen, Shan, Clark, Gary D, Coakley, Terra R, Cooper, Cynthia M, Cope, Heidi, Craigen, William J, D'Souza, Precilla, Davids, Mariska, Davidson, Jean M, Dayal, Jyoti G, Dell'Angelica, Esteban C, Dhar, Shweta U, Dipple, Katrina M, Donnell‐Fink, Laurel A, Dorrani, Naghmeh, Dorset, Daniel C, Douine, Emilie D, Draper, David D, Dries, Annika M, Eckstein, David J, Emrick, Lisa T, Eng, Christine M, Enns, Gregory M, Eskin, Ascia, Esteves, Cecilia, Estwick, Tyra, Fernandez, Liliana, Ferreira, Carlos, Fisher, Paul G, Fogel, Brent L, Friedman, Noah D, Gahl, William A, Glanton, Emily, Godfrey, Rena A, Goldman, Alica M, Goldstein, David B, Gould, Sarah E, Gourdine, Jean‐Philippe F, Groden, Catherine A, Gropman, Andrea L, Haendel, Melissa, Hanchard, Neil A, Handley, Lori H, Herzog, Matthew R, High, Francis, Holm, Ingrid A, Hom, Jason, Howerton, Ellen M, Huang, Yong, Jamal, Fariha, Jiang, Yong‐hui, and Johnston, Jean M

Subjects
Biological Sciences, Genetics, Rare Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adolescent, CD4-Positive T-Lymphocytes, Genetic Variation, Humans, Immunoglobulin G, Immunoglobulin G4-Related Disease, Male, Middle Aged, T-Lymphocytes, Cytotoxic, cytotoxic lymphocytes, heritable, IgG4-RD, Undiagnosed Disease Network, Medicinal and Biomolecular Chemistry, Clinical Sciences, Medicinal and biomolecular chemistry
Abstract

BackgroundFamily screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons.MethodsWe performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cytotoxic CD4+ T lymphocytes and plasmablasts to seek clues to pathogenesis. DNA from a separate cohort of 99 patients with known IgG4-RD was also sequenced for the presence of genetic variants in a specific gene, FGFBP2.ResultsThe three share a previously unreported heterozygous single base deletion in fibroblast growth factor binding protein type 2 (FGFBP2), which causes a frameshift in the coding sequence. The FGFBP2 protein is secreted by cytotoxic T-lymphocytes and binds fibroblast growth factor. The variant sequence in the FGFBP2 protein is predicted to form a disordered random coil rather than a helical-turn-helix structure, unable to adopt a stable conformation. The proband and the two sons had 5-10-fold higher numbers of circulating cytotoxic CD4 + T cells and plasmablasts compared to matched controls. The three members also share a homozygous missense common variant in FGFBP2 found in heterozygous form in ~40% of the population. This common variant was found in 73% of an independent, well characterized IgG4-RD cohort, showing enrichment in idiopathic IgG4-RD.ConclusionsThe presence of a shared deleterious variant and homozygous common variant in FGFBP2 in the proband and sons strongly implicates this cytotoxic T cell product in the pathophysiology of IgG4-RD. The high prevalence of a common FGFBP2 variant in sporadic IgG4-RD supports the likelihood of participation in disease.

Published
2019

10. Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

Author

Kaneko, Naoki, Boucau, Julie, Kuo, Hsiao-Hsuan, Perugino, Cory, Mahajan, Vinay S., Farmer, Jocelyn R., Liu, Hang, Diefenbach, Thomas J., Piechocka-Trocha, Alicja, Lefteri, Kristina, Waring, Michael T., Premo, Katherine R., Walker, Bruce D., Li, Jonathan Z., Gaiha, Gaurav, Yu, Xu G., Lichterfeld, Mathias, Padera, Robert F., Jr, and Pillai, Shiv

Published
2022
Full Text
View/download PDF

14. CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease

Author

Perugino, Cory A., Kaneko, Naoki, Maehara, Takashi, Mattoo, Hamid, Kers, Jesper, Allard-Chamard, Hugues, Mahajan, Vinay S., Liu, Hang, Della-Torre, Emanuel, Murphy, Samuel J.H., Ghebremichael, Musie, Wallace, Zachary S., Bolster, Marcy B., Harvey, Liam M., Mylvaganam, Geetha, Tuncay, Yesim, Liang, Lloyd, Montesi, Sydney B., Zhang, Xiuwei, Tinju, Akira, Mochizuki, Keita, Munemura, Ryusuke, Sakamoto, Mizuki, Moriyama, Masafumi, Nakamura, Seiji, Yosef, Nir, Stone, John H., and Pillai, Shiv

Published
2021
Full Text
View/download PDF

19. Cytotoxic [CD4.sup.+] T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

Author

Maehara, Takashi, Kaneko, Naoki, Perugino, Cory A., Mattoo, Hamid, Kers, Jesper, Allard-Chamard, Hugues, Mahajan, Vinay S., Liu, Hang, Murphy, Samuel J.H., Ghebremichael, Musie, Fox, David, Payne, Aimee S., Lafyatis, Robert, Stone, John H., Khanna, Dinesh, and Pillai, Shiv

Subjects
Analysis, Development and progression, Apoptosis -- Analysis, B cells -- Analysis, Scleroderma (Disease) -- Development and progression, Endothelium -- Analysis, Skin -- Analysis, T cells -- Analysis, Biochemistry, Cell death, Lymphocytes, Fibrosis, Diseases
Abstract

Introduction Systemic sclerosis (SSc) is a systemic autoimmune inflammatory disorder of unknown etiology characterized by prominent fibrosis that may affect many organs including the skin, lungs, kidneys, and gastrointestinal tract [...], Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that [CD4.sup.+] cytotoxic T cells and [CD8.sup.+] T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR-expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic [CD4.sup.+] T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

Published
2020
Full Text
View/download PDF

33. Case 18-2023: A 19-Year-Old Woman with Dyspnea and Tachypnea.

Author

Perugino, Cory A., Isselbacher, Eric M., Baliyan, Vinit, Unizony, Sebastian H., and Smith, Rex N.

Subjects
*TAKAYASU arteritis, *TACHYPNEA, *MAGNETIC resonance angiography, *DYSPNEA, *BRACHIOCEPHALIC trunk, *GIANT cell arteritis
Abstract

The article presents a case of a 19-year-old female who was rushed to a hospital due to respiratory failure and pain in her right flank and right flank to discuss tachypnea and dyspnea. She reported sustained cough and progressively deteriorating dyspnea. Computed tomography (CT) of the chest showed pericardial and pleural effusions, and her differential diagnoses like myocardial disease, pulmonary disease, and noninfectious aortitis.

Published
2023
Full Text
View/download PDF

35. List of Contributors

Author

Amaya, Enrique, primary, Awan, Imad M., additional, Bellen, Hugo J., additional, Bertero, Alessandro, additional, Brindley, David, additional, Brown, Stephanie, additional, Budge, Eleanor Jane, additional, Chantzoura, Eleni, additional, Collin, John, additional, Coutts, Amanda S., additional, Dorey, Karel, additional, Drijvers, Jefte M., additional, Gwozdz, Tomasz, additional, Hawkins, Gregory A., additional, Ishibashi, Shoko, additional, Jacks, Tyler, additional, Jalali, Mehdi, additional, Jalali, Morteza, additional, Joshi, Sonali, additional, Kaji, Keisuke, additional, La Thangue, Nicholas B., additional, Lambert, Laurens J., additional, Lea, Robert, additional, Lukoseviciute, Martyna, additional, Martin, Paul, additional, Muzumdar, Mandar D., additional, Park, Frederick D., additional, Perugino, Cory A., additional, Pettitt, Adam, additional, Pettitt, David, additional, Pillai, Shiv, additional, Reya, Tannishtha, additional, Rideout, William M., additional, Roberts, MacKenna, additional, Rosenberg, Ian M., additional, Saldanha, Francesca Y.L., additional, Sasik, Roman, additional, Segeritz, Charis-P., additional, Sheikh, Semira, additional, Smith, James, additional, Vallier, Ludovic, additional, Wangler, Michael F., additional, Yu, Dihua, additional, and Zaborowska, Justyna, additional

Published
2017
Full Text
View/download PDF

36. Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome

Author

Kaneko, Naoki, primary, Chen, Hu, additional, Perugino, Cory A, additional, Maehara, Takashi, additional, Munemura, Ryusuke, additional, Yokomizo, Shiho, additional, Sameshima, Junsei, additional, Diefenbach, Thomas J, additional, Chinju, Akira, additional, Miyahara, Yuka, additional, Sakamoto, Mizuki, additional, Moriyama, Masafumi, additional, Stone, John H, additional, Nakamura, Seiji, additional, and Pillai, Shiv, additional

Published
2022
Full Text
View/download PDF

38. Congruent microbiome signatures in fibrosis-prone autoimmune diseases

Author

Plichta, Damian R., Somani, Juhi, Pichaud, Matthieu, Wallace, Zachary S., Fernandes, Ana D., Perugino, Cory A., Lähdesmäki, Harri, Stone, John H., Vlamakis, Hera, Chung, Daniel C., Khanna, Dinesh, Pillai, Shiv, Xavier, Ramnik J., Broad Institute, Professorship Lähdesmäki Harri, Novartis USA, Massachusetts General Hospital, Computer Science Professors, University of Michigan, Ann Arbor, Massachusetts Institute of Technology, Department of Computer Science, Aalto-yliopisto, and Aalto University

Subjects
Gut microbiome, integumentary system, IgG4-RD, Systemic sclerosis, Autoimmunity, skin and connective tissue diseases
Abstract

Funding Information: SP and RJX were supported by National Institute of Allergy and Infectious Diseases (NIAID) grant U19 AI110495. JHS, CAP, ZSW, and ADF were supported by NIAID grant UM1 AI144295. DK was supported by NIAID grant UM1 AI110557 to the University of Michigan and National Institute of Arthritis and Musculoskeletal and Skin Diseases grant K24 AR063120. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Background: Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. Methods: The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no recent antibiotic treatment were studied by metagenomic sequencing of stool DNA. De novo assembly-based taxonomic and functional characterization, followed by association and accessory gene set enrichment analysis, were applied to describe microbiome changes associated with both diseases. Results: Microbiomes of IgG4-RD and SSc patients distinctly separated from those of healthy controls: numerous opportunistic pathogenic Clostridium and typically oral Streptococcus species were significantly overabundant, while Alistipes, Bacteroides, and butyrate-producing species were depleted in the two diseases compared to healthy controls. Accessory gene content analysis in these species revealed an enrichment of Th17-activating Eggerthella lenta strains in IgG4-RD and SSc and a preferential colonization of a homocysteine-producing strain of Clostridium bolteae in SSc. Overabundance of the classical mevalonate pathway, hydroxyproline dehydratase, and fibronectin-binding protein in disease microbiomes reflects potential functional differences in host immune recognition and extracellular matrix utilization associated with fibrosis. Strikingly, the majority of species that were differentially abundant in IgG4-RD and SSc compared to controls showed the same directionality in both diseases. Compared with multiple sclerosis and rheumatoid arthritis, the gut microbiomes of IgG4-RD and SSc showed similar signatures; in contrast, the most differentially abundant taxa were not the facultative anaerobes consistently identified in inflammatory bowel diseases, suggesting the microbial signatures of IgG4-RD and SSc do not result from mucosal inflammation and decreased anaerobism. Conclusions: These results provide an initial characterization of gut microbiome ecology in fibrosis-prone IgG4-RD and SSc and reveal microbial functions that offer insights into the pathophysiology of these rare diseases.

Published
2021

43. Preferential expansion upon boosting of cross-reactive “pre-existing” switched memory B cells that recognize the SARS-CoV-2 Omicron variant Spike protein

Author

Perugino, Cory A., primary, Liu, Hang, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Jacob-Dolan, Catherine, additional, Nathan, Anusha, additional, Zhou, Zezhou, additional, Kaseke, Clarety, additional, Tano-Menka, Rhoda, additional, Getz, Matthew A., additional, Senjobe, Fernando, additional, Berrios, Cristhian, additional, Ofoman, Onosereme, additional, Lemieux, Jacob E., additional, Goldberg, Marcia B., additional, Nundel, Kerstin, additional, Moormann, Ann, additional, Marshak-Rothstein, Ann, additional, Iafrate, John A., additional, Gaiha, Gaurav, additional, Charles, Richelle, additional, Balazs, Alejandro B., additional, Naranbhai, Vivek, additional, Schmidt, Aaron G., additional, and Pillai, Shiv, additional

Published
2022
Full Text
View/download PDF

44. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease

Author

Wallace, Zachary S, Naden, Ray P, Chari, Suresh, Choi, Hyon K, Della-Torre, Emanuel, Dicaire, Jean-Francois, Hart, Phillip A, Inoue, Dai, Kawano, Mitsuhiro, Khosroshahi, Arezou, Lanzillotta, Marco, Okazaki, Kazuichi, Perugino, Cory A, Sharma, Amita, Saeki, Takako, Schleinitz, Nicolas, Takahashi, Naoki, Umehara, Hisanori, Zen, Yoh, Stone, Collaborators: Akamizu T, John H., Akiyama, M, Barra, L, Bateman, A, Blockmans, D, Brito-Zeron, P, Campochiaro, C, Carruthers, M, Chiba, T, Cornell, L, Culver, E, Darabian, S, Deshpande, V, Dong, L, Ebbo, M, Fernández-Codina, A, Ferry, Ja, Fragkoulis, G, Frost, F, Frulloni, Luca, Hernandez-Molina, G, Ji, H, Keat, K, Kamisawa, T, Kawa, S, Kobayashi, H, Kodama, Y, Kubo, S, Kubota, K, Leng, H, Lerch, Mm, Liu, Y, Liu, Z, Löhr, M, Martin-Nares, E, Martinez-Valle, F, Marvisi, C, Masaki, Y, Matsui, S, Mizushima, I, Nakamura, S, Nordeide, J, Notohara, K, Paira, S, Popovic, J, Ramos-Casals, M, Rosenbaum, J, Ryu, J, Sato, Y, Sekiguchi, H, Sokol, Ev, Stone, Jr, Sun, W, Takahashi, H, Takahira, M, Tanaka, Y, Vaglio, A, Villamil, A, Wada, Y, Webster, G, Yamada, K, Yamamoto, M, Yi, J, Yi, Y, Zamboni, G, Zhang, W., Wallace, Z, Naden, Rp, Chari, S, Choi, Hk, DELLA TORRE, E, Dicaire, Jf, Hart, Pa, Inoue, D, Kawano, M, Khosroshahi, A, Lanzillotta, M, Okazaki, K, Perugino, Ca, Sharma, A, Saeki, T, Schleinitz, N, Takahashi, N, Umehara, H, Zen, Y, Stone, Jh, and Members of the ACR/EULAR IgG4-RD Classification Criteria Working, Group.

Subjects
rheumatoid arthritis, Adult, Male, 0301 basic medicine, medicine.medical_specialty, Immunology, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, parasitic diseases, Epidemiology, Humans, Immunology and Allergy, Medicine, Pathological, Sjøgren's syndrome, Aged, 030203 arthritis & rheumatology, business.industry, Middle Aged, inflammation, medicine.disease, Test (assessment), 030104 developmental biology, Rheumatoid arthritis, Radiological weapon, Female, Immunoglobulin G4-Related Disease, business, Rheumatism, Decision analysis
Abstract

IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises; existing literature; derivation and validation cohorts of 1879 subjects (1086 cases, 793 mimickers); and multicriterion decision analysis to identify, weight and test potential classification criteria. Two independent validation cohorts were included. A three-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least one of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serological, radiological and pathological items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, eight weighted inclusion criteria domains, addressing clinical findings, serological results, radiological assessments and pathological interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% CI 97.2% to 99.8%) and a sensitivity of 85.5% (95% CI 81.9% to 88.5%). In the second, the specificity was 97.8% (95% CI 93.7% to 99.2%) and the sensitivity was 82.0% (95% CI 77.0% to 86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiological and basic science investigations.

Published
2019
Full Text
View/download PDF

46. Vaccine serologic responses among transplant patients associate with COVID-19 infection and T peripheral helper cells

Author

Lemieux, Jacob E., primary, Li, Amy, additional, Gentili, Matteo, additional, Perugino, Cory A., additional, Weiss, Zoe F., additional, Bowman, Kathryn, additional, Ankomah, Pierre, additional, Liu, Hang, additional, Lewis, Gregory D., additional, Bitar, Natasha, additional, Lipiner, Taryn, additional, Hacohen, Nir, additional, Pillai, Shiv S., additional, and Goldberg, Marcia B., additional

Published
2021
Full Text
View/download PDF

47. Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren’s syndrome.

Author

Kaneko, Naoki, Chen, Hu, Perugino, Cory A., Maehara, Takashi, Munemura, Ryusuke, Yokomizo, Shiho, Sameshima, Junsei, Diefenbach, Thomas J., Premo, Katherine R., Chinju, Akira, Miyahara, Yuka, Sakamoto, Mizuki, Moriyama, Masafumi, Stone, John H., Nakamura, Seiji, and Pillai, Shiv

Abstract

Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren’s syndrome were undertaken, including the quantitation of the frequency of selected cell–cell interactions in the disease milieu. Quantitative analyses of CD4+ T cell subsets and of CD8+ T cells in the labial salivary glands from untreated patients with primary Sjögren’s syndrome revealed that activated CD8+ cytotoxic T cells (CD8+CTLs) were the most prominent T cells in these infiltrates. An accumulation of apoptotic glandular epithelial cells, mainly ductal and acinar cells, was observed, consistent with the impaired salivary secretion often observed in patients with this disease. FasL expressing activated CD8+ T cells were seen to accumulate around Fas expressing apoptotic epithelial cells. Quantitative analyses of apoptotic cell types and of conjugates between cytotoxic T cells and epithelial cells undergoing apoptosis suggest that Sjögren’s syndrome is primarily driven by CD8+CTL mediated execution of epithelial cells mainly represented by ductal and acinar cells. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

48. Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

Author

Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics, Plichta, Damian R., Somani, Juhi, Pichaud, Matthieu, Wallace, Zachary S., Fernandes, Ana D., Perugino, Cory A., Lähdesmäki, Harri, Stone, John H., Vlamakis, Hera, Chung, Daniel C., Khanna, Dinesh, Pillai, Shiv, Xavier, Ramnik J., Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics, Plichta, Damian R., Somani, Juhi, Pichaud, Matthieu, Wallace, Zachary S., Fernandes, Ana D., Perugino, Cory A., Lähdesmäki, Harri, Stone, John H., Vlamakis, Hera, Chung, Daniel C., Khanna, Dinesh, Pillai, Shiv, and Xavier, Ramnik J.

Abstract

Background Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. Methods The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no recent antibiotic treatment were studied by metagenomic sequencing of stool DNA. De novo assembly-based taxonomic and functional characterization, followed by association and accessory gene set enrichment analysis, were applied to describe microbiome changes associated with both diseases. Results Microbiomes of IgG4-RD and SSc patients distinctly separated from those of healthy controls: numerous opportunistic pathogenic Clostridium and typically oral Streptococcus species were significantly overabundant, while Alistipes, Bacteroides, and butyrate-producing species were depleted in the two diseases compared to healthy controls. Accessory gene content analysis in these species revealed an enrichment of Th17-activating Eggerthella lenta strains in IgG4-RD and SSc and a preferential colonization of a homocysteine-producing strain of Clostridium bolteae in SSc. Overabundance of the classical mevalonate pathway, hydroxyproline dehydratase, and fibronectin-binding protein in disease microbiomes reflects potential functional differences in host immune recognition and extracellular matrix utilization associated with fibrosis. Strikingly, the majority of species that were differentially abundant in IgG4-RD and SSc compared to controls showed the same directionality in both diseases. Compared with multiple sclerosis and rheumatoid arthritis, the gut microbiomes of IgG4-RD and SSc showed similar signatures; in contrast, the most differentially abundant taxa were not the facultative

Published
2021

50. Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19

Author

Kaneko, Naoki, primary, Boucau, Julie, additional, Kuo, Hsiao-Hsuan, additional, Perugino, Cory, additional, Mahajan, Vinay S., additional, Farmer, Jocelyn R., additional, Liu, Hang, additional, Diefenbach, Thomas J., additional, Piechocka-Trocha, Alicja, additional, Lefteri, Kristina, additional, Waring, Michael T., additional, Premo, Katherine R., additional, Walker, Bruce D., additional, Li, Jonathan Z., additional, Gaiha, Gaurav, additional, Yu, Xu G., additional, Lichterfeld, Mathias, additional, Padera, Robert F., additional, and Pillai, Shiv, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results