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450 results on '"Pesatori, A. C."'

1. Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy

Author

Arosio, M., Sciannameo, V., Contarino, A., Berchialla, P., Puglisi, S., Pesatori, A. C., Ferrante, E., Filopanti, M., Pivonello, R., Dassie, F., Rochira, V., Cannavò, S., De Menis, E., Pigliaru, F., Grottoli, S., Cambria, V., Faustini-Fustini, M., Montini, M., Peri, A., Ceccato, F., Puxeddu, E., Borretta, G., Bondanelli, M., Ferone, D., Colao, A., Terzolo, M., and Reimondo, G.

Published
2024
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2. Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family

Author

Brown, Kevin M., Xu, Mai, Sargen, Michael, Jang, Hyunbum, Zhang, Mingzhen, Zhang, Tongwu, Zhu, Bin, Jones, Kristie, Kim, Jung, Mendoza, Laura, Hayward, Nicholas K., Tucker, Margaret A., Goldstein, Alisa M., Yang, Xiaohong Rose, Stewart, Douglas R., Hicks, Belynda, Consonni, Dario, Pesatori, Angela C., Fargnoli, Maria Concetta, Peris, Ketty, Stratigos, Alex, Menin, Chiara, Ghiorzo, Paola, Puig, Susana, Nagore, Eduardo, Andresson, Thorkell, Nussinov, Ruth, Calista, Donato, and Landi, Maria Teresa

Published
2022
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3. Genomic and evolutionary classification of lung cancer in never smokers

Author

Zhang, Tongwu, Joubert, Philippe, Ansari-Pour, Naser, Zhao, Wei, Hoang, Phuc H., Lokanga, Rachel, Moye, Aaron L., Rosenbaum, Jennifer, Gonzalez-Perez, Abel, Martínez-Jiménez, Francisco, Castro, Andrea, Muscarella, Lucia Anna, Hofman, Paul, Consonni, Dario, Pesatori, Angela C., Kebede, Michael, Li, Mengying, Gould Rothberg, Bonnie E., Peneva, Iliana, Schabath, Matthew B., Poeta, Maria Luana, Costantini, Manuela, Hirsch, Daniela, Heselmeyer-Haddad, Kerstin, Hutchinson, Amy, Olanich, Mary, Lawrence, Scott M., Lenz, Petra, Duggan, Maire, Bhawsar, Praphulla M. S., Sang, Jian, Kim, Jung, Mendoza, Laura, Saini, Natalie, Klimczak, Leszek J., Islam, S. M. Ashiqul, Otlu, Burcak, Khandekar, Azhar, Cole, Nathan, Stewart, Douglas R., Choi, Jiyeon, Brown, Kevin M., Caporaso, Neil E., Wilson, Samuel H., Pommier, Yves, Lan, Qing, Rothman, Nathaniel, Almeida, Jonas S., Carter, Hannah, Ried, Thomas, Kim, Carla F., Lopez-Bigas, Nuria, Garcia-Closas, Montserrat, Shi, Jianxin, Bossé, Yohan, Zhu, Bin, Gordenin, Dmitry A., Alexandrov, Ludmil B., Chanock, Stephen J., Wedge, David C., and Landi, Maria Teresa

Published
2021
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6. Lung Cancer Among Firefighters : Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies

Author

Bigert, Carolina, Gustavsson, Per, Straif, Kurt, Taeger, Dirk, Pesch, Beate, Kendzia, Benjamin, Schüz, Joachim, Stücker, Isabelle, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Pesatori, Angela C., Landi, Maria Teresa, Caporaso, Neil, Tse, Lap Ah, Yu, Ignatius Tak-sun, Siemiatycki, Jack, Lavoué, Jérôme, Richiardi, Lorenzo, Mirabelli, Dario, Simonato, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardón, Adonina, Zaridze, David, Field, John K., Mannetje, Andrea ’t, Pearce, Neil, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Peters, Susan, Vermeulen, Roel, Kromhout, Hans, Brüning, Thomas, and Olsson, Ann C.

Published
2016

9. Protein-altering germline mutations implicate novel genes related to lung cancer development

Author

Ji, Xuemei, Mukherjee, Semanti, Landi, Maria Teresa, Bosse, Yohan, Joubert, Philippe, Zhu, Dakai, Gorlov, Ivan, Xiao, Xiangjun, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Brhane, Yonathan, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Byun, Jinyoung, Dragnev, Konstantin H., Field, John K., Kiemeney, Lambertus FA., Lazarus, Philip, Zienolddiny, Shan, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Bertazzi, Pier A., Pesatori, Angela C., Diao, Nancy, Su, Li, Song, Lei, Zhang, Ruyang, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Heijden, Erik H. F. M. van der, Kim, Jin Hee, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, Erich, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Butler, Lesley M., Offit, Kenneth, Srinivasan, Preethi, Bandlamudi, Chaitanya, Hellmann, Matthew D., Solit, David B., Robson, Mark E., Rudin, Charles M., Stadler, Zsofia K., Taylor, Barry S., Berger, Michael F., Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma’en, Timens, Wim, Artigas, María Soler, Shete, Sanjay, Brenner, Hermann, Chanock, Stephen, Brennan, Paul, McKay, James D., and Amos, Christopher I.

Published
2020
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12. Exposure to Dioxin and Nonneoplastic Mortality in the Expanded IARC International Cohort Study of Phenoxy Herbicide and Chlorophenol Production Workers and Sprayers

Author

Vena, John, Boffetta, Paolo, Becher, Heiko, Benn, Trevor, Coggon, David, Colin, Didier, Flesch-Janys, Dieter, Green, Lois, Kauppinen, Timo, Littorin, Margareta, Lynge, Elsebeth, Mathews, John D., Neuberger, Manfred, Pearce, Neil, Pesatori, Angela C., Saracci, Rodolfo, Steenland, Kyle, and Kogevinas, Manolis

Published
1998
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13. Abstract 1166: APOBEC deaminases compete with tobacco smoking mutagenesis and affect age at onset of lung cancer

Author

Zhang, Tongwu, primary, Sang, Jian, additional, Hoang, Phuc H., additional, Zhao, Wei, additional, Rosenbaum, Jennifer, additional, Klimczak, Leszek J., additional, McElderry, John, additional, Klein, Alyssa, additional, Wirth, Christopher, additional, Bergstrom, Erik N., additional, Díaz-Gay, Marcos, additional, Vangara, Raviteja, additional, Hutchinson, Amy, additional, Lawrence, Scott M., additional, Cole, Nathan, additional, Zhu, Bin, additional, Przytycka, Teresa M., additional, Shi, Jianxin, additional, Caporaso, Neil E., additional, Homer, Robert, additional, Pesatori, Angela C., additional, Consonni, Dario, additional, Chanock, Stephen J., additional, Wedge, David C., additional, Gordenin, Dmitry A., additional, Alexandrov, Ludmil B., additional, Harris, Reuben S., additional, and Landi, Maria Teresa, additional

Published
2023
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14. Data from Inherited Variation at Chromosome 12p13.33, Including RAD52, Influences the Risk of Squamous Cell Lung Carcinoma

Author

Shi, Jianxin, primary, Chatterjee, Nilanjan, primary, Rotunno, Melissa, primary, Wang, Yufei, primary, Pesatori, Angela C., primary, Consonni, Dario, primary, Li, Peng, primary, Wheeler, William, primary, Broderick, Peter, primary, Henrion, Marc, primary, Eisen, Timothy, primary, Wang, Zhaoming, primary, Chen, Wei, primary, Dong, Qiong, primary, Albanes, Demetrius, primary, Thun, Michael, primary, Spitz, Margaret R., primary, Bertazzi, Pier Alberto, primary, Caporaso, Neil E., primary, Chanock, Stephen J., primary, Amos, Christopher I., primary, Houlston, Richard S., primary, and Landi, Maria Teresa, primary

Published
2023
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15. Supplementary Methods, Figure 1, Tables 1-6 from Inherited Variation at Chromosome 12p13.33, Including RAD52, Influences the Risk of Squamous Cell Lung Carcinoma

Author

Shi, Jianxin, primary, Chatterjee, Nilanjan, primary, Rotunno, Melissa, primary, Wang, Yufei, primary, Pesatori, Angela C., primary, Consonni, Dario, primary, Li, Peng, primary, Wheeler, William, primary, Broderick, Peter, primary, Henrion, Marc, primary, Eisen, Timothy, primary, Wang, Zhaoming, primary, Chen, Wei, primary, Dong, Qiong, primary, Albanes, Demetrius, primary, Thun, Michael, primary, Spitz, Margaret R., primary, Bertazzi, Pier Alberto, primary, Caporaso, Neil E., primary, Chanock, Stephen J., primary, Amos, Christopher I., primary, Houlston, Richard S., primary, and Landi, Maria Teresa, primary

Published
2023
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16. Supplementary Material 2 from A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma

Author

Rotunno, Melissa, primary, Hu, Nan, primary, Su, Hua, primary, Wang, Chaoyu, primary, Goldstein, Alisa M., primary, Bergen, Andrew W., primary, Consonni, Dario, primary, Pesatori, Angela C., primary, Bertazzi, Pier Alberto, primary, Wacholder, Sholom, primary, Shih, Joanna, primary, Caporaso, Neil E., primary, Taylor, Phil R., primary, and Landi, Maria Teresa, primary

Published
2023
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17. Data from A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma

Author

Rotunno, Melissa, primary, Hu, Nan, primary, Su, Hua, primary, Wang, Chaoyu, primary, Goldstein, Alisa M., primary, Bergen, Andrew W., primary, Consonni, Dario, primary, Pesatori, Angela C., primary, Bertazzi, Pier Alberto, primary, Wacholder, Sholom, primary, Shih, Joanna, primary, Caporaso, Neil E., primary, Taylor, Phil R., primary, and Landi, Maria Teresa, primary

Published
2023
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18. Supplementary Material 1 from A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma

Author

Rotunno, Melissa, primary, Hu, Nan, primary, Su, Hua, primary, Wang, Chaoyu, primary, Goldstein, Alisa M., primary, Bergen, Andrew W., primary, Consonni, Dario, primary, Pesatori, Angela C., primary, Bertazzi, Pier Alberto, primary, Wacholder, Sholom, primary, Shih, Joanna, primary, Caporaso, Neil E., primary, Taylor, Phil R., primary, and Landi, Maria Teresa, primary

Published
2023
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19. Data from MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer

Author

Landi, Maria Teresa, primary, Zhao, Yingdong, primary, Rotunno, Melissa, primary, Koshiol, Jill, primary, Liu, Hui, primary, Bergen, Andrew W., primary, Rubagotti, Maurizia, primary, Goldstein, Alisa M., primary, Linnoila, Ilona, primary, Marincola, Francesco M., primary, Tucker, Margaret A., primary, Bertazzi, Pier Alberto, primary, Pesatori, Angela C., primary, Caporaso, Neil E., primary, McShane, Lisa M., primary, and Wang, Ena, primary

Published
2023
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23. Supplementary Data from MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer

Author

Landi, Maria Teresa, primary, Zhao, Yingdong, primary, Rotunno, Melissa, primary, Koshiol, Jill, primary, Liu, Hui, primary, Bergen, Andrew W., primary, Rubagotti, Maurizia, primary, Goldstein, Alisa M., primary, Linnoila, Ilona, primary, Marincola, Francesco M., primary, Tucker, Margaret A., primary, Bertazzi, Pier Alberto, primary, Pesatori, Angela C., primary, Caporaso, Neil E., primary, McShane, Lisa M., primary, and Wang, Ena, primary

Published
2023
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28. Air Pollution and Perinatal Mental Health: A Comprehensive Overview

Author

Surace, T, Quitadamo, C, Caldiroli, A, Capuzzi, E, Colmegna, F, Nosari, G, Borroni, E, Fedrizzi, L, Bollati, V, Pesatori, A, Carugno, M, Clerici, M, Buoli, M, Surace T., Quitadamo C., Caldiroli A., Capuzzi E., Colmegna F., Nosari G., Borroni E., Fedrizzi L., Bollati V., Pesatori A. C., Carugno M., Clerici M., Buoli M., Surace, T, Quitadamo, C, Caldiroli, A, Capuzzi, E, Colmegna, F, Nosari, G, Borroni, E, Fedrizzi, L, Bollati, V, Pesatori, A, Carugno, M, Clerici, M, Buoli, M, Surace T., Quitadamo C., Caldiroli A., Capuzzi E., Colmegna F., Nosari G., Borroni E., Fedrizzi L., Bollati V., Pesatori A. C., Carugno M., Clerici M., and Buoli M.

Abstract

Background: The aim of the present study was to summarise the available data about the link between air pollution exposure and the new-onset and severity of psychiatric disorders in pregnant women during the perinatal period. Materials and methods: We selected articles published until June 2022 on PubMed and the Web of Science. Pollutants included were PM2.5 (particulate matter 2.5 micrometres and smaller), PM10 (particulate matter 10 micrometres and smaller), NO2 (nitrogen dioxide), O3 (ozone), SO2 (sulphur dioxide), CO (carbon monoxide), PBDEs (polybrominated diphenyl ethers), PFAS (per- and polyfluoroalkyl substances), lead, and cadmium. The perinatal period was considered as the time of pregnancy until one year after childbirth. Results: Nine studies were included; most of them evaluated the association between exposure to air pollutants and the onset of Postpartum Depression (PPD). Two studies showed an association between, respectively, only PM2.5 and both PM2.5 and NO2 exposure and PPD onset 12 months after childbirth, while another study found a significant association between NO2 exposure and PPD occurrence 6 months after childbirth. PBDE blood levels were associated with more severe depressive symptoms. Lastly, one study observed a link between stressful symptoms and exposure to PM2.5, PM10 during pregnancy. Conclusion: More comprehensive and uniform studies are required to make a roadmap for future interventions, given the growing relevance of issues such pollution and mental health, particularly during the perinatal period.

Published
2023

29. Time to first cigarette and its impact on lung tumorigenesis

Author

Zhang, Tongwu, primary, Sang, Jian, additional, Caporaso, Neil, additional, Gu, Fangyi, additional, Hutchinson, Amy, additional, Consonni, Dario, additional, Pesatori, Angela C., additional, Homer, Robert, additional, Chanock, Stephen, additional, and Landi, Maria Teresa, additional

Published
2022
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30. Lung Cancer Risk Among Cooks When Accounting for Tobacco Smoking : A Pooled Analysis of Case–Control Studies From Europe, Canada, New Zealand, and China

Author

Bigert, Carolina, Gustavsson, Per, Straif, Kurt, Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Schüz, Joachim, Stücker, Isabelle, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Pesatori, Angela C., Landi, Maria Teresa, Caporaso, Neil, Tse, Lap Ah, Yu, Ignatius Tak-sun, Siemiatycki, Jack, Pintos, Javier, Merletti, Franco, Mirabelli, Dario, Simonato, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardón, Adonina, Zaridze, David, Field, John, ‘t Mannetje, Andrea, Pearce, Neil, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Peters, Susan, Vermeulen, Roel, Kromhout, Hans, and Olsson, Ann C.

Published
2015

31. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks

Author

Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Dallari B., Pesatori A.C., Riboldi L., Merletti F., Gangemi M., Stura A., Brentisci C., Gilardetti M., Benfatto L., Canessa P.A., Malacarne D., Mazzucco G., Campi M.G., Fedeli U., Bressan V., Gioffre F., Ballarin M.N., Chermaz C., D'agostin F., De Michieli P., Mangone L., Storchi C., Sala O., Badiali A.M., Cacciarini V., Giovannetti L., Martini A., Calisti R., Pascucci C., Stracci F., Masanotti G., Davoli M., Cavariani F., Ancona L., Annunziata A., Menegozzo S., Napolitano F., Pelullo C.P., Vimercati L., Cascone G., Frasca G., Giurdanella M.C., Martorana C., Nicita C., Rollo C.P., Spata E., Dardanoni G., Scondotto S., Nieddu V., Pergola M., Stecchi S., Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Tumino, Rosario, Melis, Massimo, Curti, Stefania, Brandi, Giovanni, Mattioli, Stefano, and Iavicoli, Sergio

Subjects
medicine.medical_specialty, pericardial and tunica vaginalis testis, Epidemiology, Population, rare disease, national registry, medicine.disease_cause, Epidemiology, Italy, National registry, Rare disease, Asbestos, epidemiology, Italy, national registry, rare disease, NO, 03 medical and health sciences, 0302 clinical medicine, italy, medicine, epidemiology, Italy, Mesothelioma, education, Gynecology, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Tunica vaginalis testis, Case-control study, case–control study, Odds ratio, medicine.disease, asbestos, 030210 environmental & occupational health, National registry, exposure, mesothelioma, malignant mesothelioma, Original Article, Public aspects of medicine, RA1-1270, business, Rare disease
Abstract

Objectives: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.

Published
2020

32. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

Author

Li, Yafang, Xiao, Xiangjun, Han, Younghun, Gorlova, Olga, Qian, David, Leighl, Natasha, Johansen, Jakob S, Barnett, Matt, Chen, Chu, Goodman, Gary, Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, H -Erich, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Arnold, Susanne M, Haura, Eric B, Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M, Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J, Butler, Lesley M, Houlston, Richard, Soler Artigas, María, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A, Marcus, Michael W, Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C, Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Liu, Geoffrey, Bojesen, Stig E, Wu, Xifeng, Marchand, Loic Le, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C, Bush, William S, Tardon, Adonina, Rennert, Gad, Teare, M Dawn, Field, John K, Kiemeney, Lambertus A, Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B, Andrew, Angeline S, Bertazzi, Pier Alberto, Pesatori, Angela C, Christiani, David C, Caporaso, Neil, Johansson, Mattias, McKay, James D, Brennan, Paul, Hung, Rayjean J, and Amos, Christopher I

Published
2018
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33. Rare germline deleterious variants increase susceptibility for lung cancer

Author

Sang, Jian, primary, Zhang, Tongwu, additional, Kim, Jung, additional, Li, Mengying, additional, Pesatori, Angela C, additional, Consonni, Dario, additional, Song, Lei, additional, Liu, Jia, additional, Zhao, Wei, additional, Hoang, Phuc H, additional, Campbell, Dave S, additional, Feng, James, additional, D’Arcy, Monica E, additional, Synnott, Naoise, additional, Chen, Yingxi, additional, Wu, Zeni, additional, Zhu, Bin, additional, Yang, Xiaohong R, additional, Brown, Kevin M, additional, Choi, Jiyeon, additional, Shi, Jianxin, additional, and Landi, Maria Teresa, additional

Published
2022
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34. Patterns of multisite pain and associations with risk factors

Author

Coggon, David, Ntani, Georgia, Palmer, Keith T., Felli, Vanda E., Harari, Raul, Barrero, Lope H., Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Vargas-Prada, Sergio, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Masood Kadir, M., Warnakulasuriya, Sudath S.P., Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R., Harcombe, Helen, Cox, Ken, Marziale, Maria H., Sarquis, Leila M., Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V., Quintana, Leonardo A., Rojas, Marianela, Salazar Vega, Eduardo J., Harris, E. Clare, Serra, Consol, Martinez, J. Miguel, Delclos, George, Benavides, Fernando G., Carugno, Michele, Ferrario, Marco M., Pesatori, Angela C., Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J., Sathiakumar, Nalini, Wickremasinghe, A. Rajitha, Yoshimura, Noriko, Kelsall, Helen L., Hoe, Victor C.W, Urquhart, Donna M., Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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35. Disabling musculoskeletal pain in working populations: Is it the job, the person, or the culture?

Author

Coggon, David, Ntani, Georgia, Palmer, Keith T., Felli, Vanda E., Harari, Raul, Barrero, Lope H., Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Serra, Consol, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Masood Kadir, M., Warnakulasuriya, Sudath S.P., Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R., Harcombe, Helen, Cox, Ken, Marziale, Maria H., Sarquis, Leila M., Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V., Quintana, Leonardo A., Rojas, Marianela, Salazar Vega, Eduardo J., Harris, E. Clare, Vargas-Prada, Sergio, Martinez, J. Miguel, Delclos, George, Benavides, Fernando G., Carugno, Michele, Ferrario, Marco M., Pesatori, Angela C., Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J., Sathiakumar, Nalini, Wickremasinghe, A. Rajitha, Yoshimura, Noriko, Kelsall, Helen L., Hoe, Victor C.W., Urquhart, Donna M., Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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36. Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity

Author

Macchi, Chiara, Greco, Maria Francesca, Favero, Chiara, Dioni, Laura, Cantone, Laura, Hoxha, Mirjam, Vigna, Luisella, Solazzo, Giulia, Corsini, Alberto, Banach, Maciej, Pesatori, Angela C., Bollati, Valentina, and Ruscica, Massimiliano

Subjects
obesity, miR-150, PCSK9 (proprotein convertase subtilisin kexin type 9), Cardiovascular Medicine, atherosclerosis, extracellular vesicles (EVs), low-density lipoprotein receptor (LDLR), Original Research
Abstract

Background: Extracellular vesicles (EV) concentration is generally increased in patients with cardiovascular diseases, although the protective role of EVs in atherosclerosis has been reported. Among the specific cargo of EVs, miRNAs contribute to different stages of atherosclerosis. Aim of the present report has been to investigate, in individuals with obesity, the interplay among EVs derived from cells relevant for the atherosclerotic process (i.e., platelets, endothelium, monocytes/macrophages, and neutrophils), their miRNA content and proprotein convertase subtilisin/kexin type 9 (PCSK9), one of the main regulators of low-density lipoprotein receptor (LDLR). Methods and Results: EVs have been isolated from 936 individuals with obesity (body mass index = 33.6 ± 5.6 Kg/m2) and a raised cardiovascular risk (e.g., LDL-C = 131.6 ± 36.4 mg/dL, HOMA-IR = 3.1, and roughly 50% on anti-hypertensive medications). PCSK9 levels were negatively associated with EV count in the range 150–400 nm and with those derived from macrophages (CD14+), endothelium (CD105+), and neutrophils (CD66+). The association between PCSK9 and platelet-derived EVs (CD61+) was modified by platelet counts. PCSK9 was significantly associated with five EV-derived miRNAs (hsa-miRNA−362−5p,−150,−1244,−520b-3p,−638). Toll-like receptor 4 and estrogen receptor 1 were targeted by all five miRNAs and LDLR by four. The effect on LDLR expression is mainly driven by hsa-miR-150. Considering the implication of EV in atherosclerosis onset and progression, our findings show a potential role of PCSK9 to regulate EV-derived miRNAs, especially those involved in inflammation and expression of low-density lipoprotein receptor (LDLR) receptor.

Published
2022

39. Lung cancer risk among bricklayers in a pooled analysis of case–control studies

Author

Consonni, Dario, Matteis, Sara De, Pesatori, Angela C., Bertazzi, Pier Alberto, Olsson, Ann C., Kromhout, Hans, Peters, Susan, Vermeulen, Roel C.H., Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Behrens, Thomas, Stücker, Isabelle, Guida, Florence, Wichmann, Heinz-Erich, Brüske, Irene, Landi, Maria Teresa, Caporaso, Neil E., Gustavsson, Per, Plato, Nils, Tse, Lap Ah, Yu, Ignatius Tak-sun, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Forastiere, Francesco, Siemiatycki, Jack, Parent, Marie-Élise, Tardón, Adonina, Boffetta, Paolo, Zaridze, David, Chen, Ying, Field, John K., Mannetje, Andreaʼt, Pearce, Neil, McLaughlin, John, Demers, Paul, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Rudnai, Peter, Fabiánová, Eleonóra, Dumitru, Rodica Stanescu, Bueno-de-Mesquita, H. B(as), Schüz, Joachim, and Straif, Kurt

Published
2015
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41. Mortality of Short-Term Workers in Two International Cohorts

Author

Boffetta, Paolo, Sali, Davide, Kolstad, Henrik, Coggon, David, Olsen, Jorgen, Andersen, Aage, Spence, Alan, Pesatori, Angela C., Lynge, Elsebeth, Frentzel-Beyme, Rainer, Chang-Claude, Jenny, Lundberg, Ingvar, Biocca, Marco, Gennaro, Valerio, Teppo, Lyly, Partanen, Timo, Welp, Esther, Saracci, Rodolfo, and Kogevinas, Manolis

Published
1998

42. Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family

Author

Brown, K. M., Xu, M., Sargen, M., Jang, H., Zhang, M., Zhang, T., Zhu, B., Jones, K., Kim, J., Mendoza, L., Hayward, N. K., Tucker, M. A., Goldstein, A. M., Yang, X. R., Stewart, D. R., Hicks, B., Consonni, D., Pesatori, A. C., Fargnoli, Maria Concetta, Peris, Ketty, Stratigos, A., Menin, C., Ghiorzo, P., Puig, S., Nagore, E., Andresson, T., Nussinov, R., Calista, D., Landi, M. T., Fargnoli M. C., Peris K. (ORCID:0000-0002-5237-0463), Brown, K. M., Xu, M., Sargen, M., Jang, H., Zhang, M., Zhang, T., Zhu, B., Jones, K., Kim, J., Mendoza, L., Hayward, N. K., Tucker, M. A., Goldstein, A. M., Yang, X. R., Stewart, D. R., Hicks, B., Consonni, D., Pesatori, A. C., Fargnoli, Maria Concetta, Peris, Ketty, Stratigos, A., Menin, C., Ghiorzo, P., Puig, S., Nagore, E., Andresson, T., Nussinov, R., Calista, D., Landi, M. T., Fargnoli M. C., and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

While several high-penetrance melanoma risk genes are known, variation in these genes fail to explain melanoma susceptibility in a large proportion of high-risk families. As part of a melanoma family sequencing study, including 435 families from Mediterranean populations we identified a novel NRAS variant (c.170A > C, p.D57A) in an Italian melanoma-prone family. This variant is absent in exomes in gnomAD, ESP, UKBiobank, and the 1000 Genomes Project, as well as in 11,273 Mediterranean individuals and 109 melanoma-prone families from the US and Australia. This variant occurs in the GTP-binding pocket of NRAS. Differently from other RAS activating alterations, NRAS D57A expression is unable to activate MAPK-pathway both constitutively and after stimulation but enhances EGF-induced PI3K-pathway signaling in serum starved conditions in vitro. Consistent with in vitro data demonstrating that NRAS D57A does not enrich GTP binding, molecular modeling suggests that the D57A substitution would be expected to impair Mg2 + binding and decrease nucleotide-binding and GTPase activity of NRAS. While we cannot firmly establish NRAS c.170A > C (p.D57A) as a melanoma susceptibility variant, further investigation of NRAS as a familial melanoma gene is warranted.

Published
2021

44. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

Author

Landi, Maria Teresa, Chatterjee, Nilanjan, Kai Yu, Goldin, Lynn R., Goldstein, Alisa M., Rotunno, Melissa, Mirabello, Lisa, Jacobs, Kevin, Wheeler, William, Yeager, Meredith, Bergen, Andrew W., Qizhai Li, Consonni, Dario, Pesatori, Angela C., Wacholder, Sholom, Thun, Michael, Diver, Ryan, Oken, Martin, Virtamo, Jarmo, Albanes, Demetrius, Zhaoming Wang, Burdette, Laurie, Doheny, Kimberly F., Pugh, Elizabeth W., Laurie, Cathy, Brennan, Paul, Rayjean Hung, Gaborieau, Valerie, McKay, James D., Lathrop, Mark, McLaughlin, John, Ying Wang, Ming-Sound Tsao, Spitz, Margaret R., Yufei Wang, Krokan, Hans, Vatten, Lars, Skorpen, Frank, Arnesen, Egil, and Benhamou, Simone

Subjects
Adenocarcinoma -- Genetic aspects, Human genome -- Research, Single nucleotide polymorphisms -- Analysis, Biological sciences
Abstract

Several genome-wide association studies are conducted to identify the different genetic loci that can be associated with lung cancer in humans. The analysis reveals the presence of a region of chromosome 5p15, which is shown to be widely related to the risk of adenocarcinoma.

Published
2009

46. Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxin

Author

Baccarelli, Andrea, Giacomini, Sara M., Corbetta, Carlo, Landi, Maria Teresa, Bonzini, Matteo, Consonni, Dario, Grillo, Paolo, Patterson, Jr., Donald G., Pesatori, Angela C., and Bertazzi, Pier Alberto

Subjects
Seveso Disaster, Italy, 1976 -- Research -- Health aspects -- Environmental aspects, Environmental health -- Research -- Health aspects -- Environmental aspects, Thyrotropin -- Environmental aspects -- Health aspects -- Research, Infants (Newborn) -- Diseases, Dioxin -- Health aspects -- Environmental aspects -- Research, Hypothyroidism -- Risk factors -- Environmental aspects -- Research, Prenatal influences -- Research -- Environmental aspects -- Health aspects, Biological sciences
Abstract

Background Neonatal hypothyroidism has been associated in animal models with maternal exposure to several environmental contaminants; however, evidence for such an association in humans is inconsistent. We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. Methods and Findings Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident we conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. We performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 µU/ml (95% confidence interval [CI] 0.90-1.08) in the reference area (n=533), 1.35 µU/ml (95% CI 1.22-1.49) in zone B (n =425), and 1.66 µU/ml (95% CI 1.19-2.31) in zone A (n = 56) (p < 0.001). The proportion of children with b-TSH > 5 µU/ml was 2.8% in the reference area, 4.9% in zone B, and 16.1% in zone A (p < 0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p < 0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005). Conclusions Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure., The Editors' Summary of this article follows the references. Introduction Variations in neonatal thyroid function evaluated at birth through blood thyroid-stimulating hormone (b-TSH) are associated with changes in iodine availability [...]

Published
2008

47. SARS-CoV-2 infection among asymptomatic homebound subjects in Milan, Italy

Author

Milani, G, Montomoli, E, Bollati, V, Albetti, B, Bandi, C, Bellini, T, Bonzini, M, Buscaglia, M, Cantarella, C, Cantone, L, Carugno, M, Casartelli, S, Cavaletti, G, D'Alessandro, S, De Chiara, F, Delbue, S, Dioni, L, Eberini, I, Favero, C, Ferrari, L, Ferraroni, M, Galastri, L, Galli, C, Hoxha, M, Iodice, S, La Vecchia, C, Macchi, C, Manini, I, Marchi, S, Mariani, J, Pariani, E, Pesatori, A, Rota, F, Ruscica, M, Schioppo, T, Tarantini, L, Trombetta, C, Valsecchi, M, Vicenzi, M, Zanchetta, G, Milani G. P., Montomoli E., Bollati V., Albetti B., Bandi C., Bellini T., Bonzini M., Buscaglia M., Cantarella C., Cantone L., Carugno M., Casartelli S., Cavaletti G., D'Alessandro S., De Chiara F., Delbue S., Dioni L., Eberini I., Favero C., Ferrari L., Ferraroni M., Galastri L., Galli C., Hoxha M., Iodice S., La Vecchia C., Macchi C., Manini I., Marchi S., Mariani J., Pariani E., Pesatori A. C., Rota F., Ruscica M., Schioppo T., Tarantini L., Trombetta C. M., Valsecchi M. G., Vicenzi M., Zanchetta G., Milani, G, Montomoli, E, Bollati, V, Albetti, B, Bandi, C, Bellini, T, Bonzini, M, Buscaglia, M, Cantarella, C, Cantone, L, Carugno, M, Casartelli, S, Cavaletti, G, D'Alessandro, S, De Chiara, F, Delbue, S, Dioni, L, Eberini, I, Favero, C, Ferrari, L, Ferraroni, M, Galastri, L, Galli, C, Hoxha, M, Iodice, S, La Vecchia, C, Macchi, C, Manini, I, Marchi, S, Mariani, J, Pariani, E, Pesatori, A, Rota, F, Ruscica, M, Schioppo, T, Tarantini, L, Trombetta, C, Valsecchi, M, Vicenzi, M, Zanchetta, G, Milani G. P., Montomoli E., Bollati V., Albetti B., Bandi C., Bellini T., Bonzini M., Buscaglia M., Cantarella C., Cantone L., Carugno M., Casartelli S., Cavaletti G., D'Alessandro S., De Chiara F., Delbue S., Dioni L., Eberini I., Favero C., Ferrari L., Ferraroni M., Galastri L., Galli C., Hoxha M., Iodice S., La Vecchia C., Macchi C., Manini I., Marchi S., Mariani J., Pariani E., Pesatori A. C., Rota F., Ruscica M., Schioppo T., Tarantini L., Trombetta C. M., Valsecchi M. G., Vicenzi M., and Zanchetta G.

Published
2020

48. Effects of aircraft noise on annoyance, sleep disorders, and blood pressure among adult residents near the Orio al Serio International Airport (BGY), Italy

Author

Carugno, Michele, Imbrogno, Piero, Zucchi, Alberto, Ciampichini, Roberta, Tereanu, Carmen, Sampietro, Giuseppe, Barbaglio, Giorgio, Pesenti, Bruno, Barretta, Francesco, Bertazzi, Pier Alberto, Pesatori, Angela C., and Consonni, Dario

Subjects
annoyance, Male, Sleep Wake Disorders, Aircraft, Airports, blood pressure, Middle Aged, Aircraft noise, Cross-Sectional Studies, Italy, Noise, Transportation, Hypertension, Humans, Original Article, sleep disorders, Female, human activities, Aged
Abstract

Background: Aircraft noise may cause several non-auditory health effects, including annoyance, sleep disorders, hypertension, cardiovascular diseases, and impaired cognitive skills in children. Objectives: To perform a cross-sectional study among adult residents near the Orio al Serio International Airport (BGY), Italy to investigate the association between aircraft noise, annoyance, sleep disorders, blood pressure levels, and prevalence of hypertension. Methods: Residential addresses of subjects aged 45-70 years were geocoded and classified in three groups according to noise levels

Published
2018

49. Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

Author

Shi, Jianxin, Hua, Xing, Zhu, Bin, Ravichandran, Sarangan, Wang, Mingyi, Nguyen, Cu, Brodie, Seth A., Palleschi, Alessandro, Alloisio, Marco, Pariscenti, Gianluca, Jones, Kristine, Zhou, Weiyin, Bouk, Aaron J., Boland, Joseph, Hicks, Belynda, Risch, Adam, Bennett, Hunter, Luke, Brian T., Song, Lei, Duan, Jubao, Liu, Pengyuan, Kohno, Takashi, Chen, Qingrong, Meerzaman, Daoud, Marconett, Crystal, Laird-Offringa, Ite, Mills, Ian, Caporaso, Neil E., Gail, Mitchell H., Pesatori, Angela C., Consonni, Dario, Bertazzi, Pier Alberto, Chanock, Stephen J., and Landi, Maria Teresa

Subjects
Lung cancer -- Genetic aspects -- Development and progression, Adenocarcinoma -- Genetic aspects -- Development and progression, Gene mutation -- Health aspects, Gene expression -- Health aspects, Biological sciences
Abstract

Background Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and has a high risk of distant metastasis at every disease stage. We aimed to characterize the genomic landscape of LUAD and identify mutation signatures associated with tumor progression. Methods and Findings We performed an integrative genomic analysis, incorporating whole exome sequencing (WES), determination of DNA copy number and DNA methylation, and transcriptome sequencing for 101 LUAD samples from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. We detected driver genes by testing whether the nonsynonymous mutation rate was significantly higher than the background mutation rate and replicated our findings in public datasets with 724 samples. We performed subclonality analysis for mutations based on mutant allele data and copy number alteration data. We also tested the association between mutation signatures and clinical outcomes, including distant metastasis, survival, and tumor grade. We identified and replicated two novel candidate driver genes, POU class 4 homeobox 2 (POU4F2) (mutated in 9 [8.9%] samples) and ZKSCAN1 (mutated in 6 [5.9%] samples), and characterized their major deleterious mutations. ZKSCAN1 was part of a mutually exclusive gene set that included the RTK/RAS/RAF pathway genes BRAF, EGFR, KRAS, MET, and NF1, indicating an important driver role for this gene. Moreover, we observed strong associations between methylation in specific genomic regions and somatic mutation patterns. In the tumor evolution analysis, four driver genes had a significantly lower fraction of subclonal mutations (FSM), including TP53 (p = 0.007), KEAP1 (p = 0.012), STK11 (p = 0.0076), and EGFR (p = 0.0078), suggesting a tumor initiation role for these genes. Subclonal mutations were significantly enriched in APOBEC-related signatures (p < 2.5x10.sup.-50). The total number of somatic mutations (p = 0.0039) and the fraction of transitions (p = 5.5x10.sup.-4) were associated with increased risk of distant metastasis. Our study's limitations include a small number of LUAD patients for subgroup analyses and a single-sample design for investigation of subclonality. Conclusions These data provide a genomic characterization of LUAD pathogenesis and progression. The distinct clonal and subclonal mutation signatures suggest possible diverse carcinogenesis pathways for endogenous and exogenous exposures, and may serve as a foundation for more effective treatments for this lethal disease. LUAD's high heterogeneity emphasizes the need to further study this tumor type and to associate genomic findings with clinical outcomes., Author(s): Jianxin Shi 1, Xing Hua 1, Bin Zhu 1, Sarangan Ravichandran 2, Mingyi Wang 1,3, Cu Nguyen 4, Seth A. Brodie 1,3, Alessandro Palleschi 5, Marco Alloisio 6, Gianluca [...]

Published
2016
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50. International variation in absence from work attributed to musculoskeletal illness: findings from the CUPID study

Author

Coggon, David, Ntani, Georgia, Vargas-Prada, Sergio, Martinez, José Miguel, Serra, Consol, Benavides, Fernando G, Palmer, Keith T, Felli, Vanda E, Harari, Raul, Barrero, Lope H, Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Kadir, M Masood, Warnakulasuriya, Sudath SP, Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R, Harcombe, Helen, Cox, Ken, Marziale, Maria H, Sarquis, Leila M, Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V, Quintana, Leonardo A, Rojas, Marianela, Vega, Eduardo J. Salazar, Harris, E Clare, Delclos, George, Carugno, Michele, Ferrario, Marco M, Pesatori, Angela C, Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J, Sathiakumar, Nalini, Wickremasinghe, A Rajitha, Yoshimura, Noriko, Kelsall, Helen L, Hoe, Victor C W, Urquhart, Donna M, Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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