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1. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models.

2. Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

3. A kinetic intra-cellular assay (KICA) to measure quantitative compound binding kinetics within living cells

4. Use of NanoBiT and NanoBRET to characterise interleukin‐23 receptor dimer formation in living cells

5. Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432

6. Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

7. Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

10. Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening

11. Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors

12. Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System

13. Development of an intracellular quantitative assay to measure compound binding kinetics

14. Structure-based design of a bromodomain and extraterminal domain (BET) inhibitor selective for the N-terminal bromodomains that retains an anti-inflammatory and antiproliferative phenotype

15. Design and Synthesis of a Highly Selective and

16. The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU

17. Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET

18. Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

19. A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification

20. Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

21. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

22. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

24. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

25. Nat Chem Biol

26. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

27. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models

28. Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry

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