72 results on '"Peter Koo"'
Search Results
2. Evaluating deep learning for predicting epigenomic profiles
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Shushan Toneyan, Peter Koo, and Ziqi Tang
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Human-Computer Interaction ,Artificial Intelligence ,Computer Networks and Communications ,Computer Vision and Pattern Recognition ,Article ,Software - Abstract
Deep learning has been successful at predicting epigenomic profiles from DNA sequences. Most approaches frame this task as a binary classification relying on peak callers to define functional activity. Recently, quantitative models have emerged to directly predict the experimental coverage values as a regression. As new models continue to emerge with different architectures and training configurations, a major bottleneck is forming due to the lack of ability to fairly assess the novelty of proposed models and their utility for downstream biological discovery. Here we introduce a unified evaluation framework and use it to compare various binary and quantitative models trained to predict chromatin accessibility data. We highlight various modeling choices that affect generalization performance, including a downstream application of predicting variant effects. In addition, we introduce a robustness metric that can be used to enhance model selection and improve variant effect predictions. Our empirical study largely supports that quantitative modeling of epigenomic profiles leads to better generalizability and interpretability.
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- 2022
3. Intellectual property rights regimes, their assets, and limitations
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Digital Innovation, Luwedde, Justine; Taylor, Peter; Koo, Jawoo; Chambers, Judith A., http://orcid.org/0000-0003-3424-9229 Koo, Jawoo; http://orcid.org/0000-0001-6442-8581 Chambers, Judith Ann, Digital Innovation, Luwedde, Justine; Taylor, Peter; Koo, Jawoo; Chambers, Judith A., and http://orcid.org/0000-0003-3424-9229 Koo, Jawoo; http://orcid.org/0000-0001-6442-8581 Chambers, Judith Ann
- Abstract
Non-PR, IFPRI5; DCA; 5 Strengthening Institutions and Governance, Innovation Policy and Scaling (IPS); Transformation Strategies, The role of intellectual property has become increasingly important in protecting creations of the mind and making day-to-day business decisions. Hence, if innovations are left unprotected, they can be exploited by competitors with capacity to commercialize them. This policy brief points out that lowand middle-income countries face intellectual property-related challenges compared to high-income countries due to inadequate intellectual property awareness, the high cost of processing patent applications, weak enforcement of intellectual property rights, and weak research and development capacity. Group of Seven (G7) countries are thus better positioned, as high-income countries, to lead globally on intellectual property enforcement, and leverage the flexibilities within the traderelated aspects of intellectual property to support and encourage future technologies in low- and middle-income countries. We propose that G7 countries support the creation of equity- and rights-based awareness on intellectual property rights, the improvement of mechanisms and systems for enforcement, and investment in research and development via building local support to reduce costs.
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- 2023
4. Letter regarding 'Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis'
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Karin Allenspach, Andreas Handel, Stanley Marks, Peter Kook, Kenny Simpson, Joseph Bartges, Kenjiro Fukushima, Aarti Kathrani, Silke Salavati, Julien Dandrieux, Caroline Mansfield, Alison Manchester, Craig Webb, Valerie Freiche, W. Zane Billings, and Jonathan P. Mochel
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Veterinary medicine ,SF600-1100 - Published
- 2024
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5. A Routing Algorithm for Harvesting Multipipeline Arrays with Small Intercell and Pipeline Delays.
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Peter Koo, Fabrizio Lombardi, and Donatella Sciuto
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- 1990
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6. Organic and Metal–Organic Polymer-Based Catalysts—Enfant Terrible Companions or Good Assistants?
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Milan Králik, Peter Koóš, Martin Markovič, and Pavol Lopatka
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organic polymer ,resin ,metal–organic framework ,catalyst ,metal ,preparations ,Organic chemistry ,QD241-441 - Abstract
This overview provides insights into organic and metal–organic polymer (OMOP) catalysts aimed at processes carried out in the liquid phase. Various types of polymers are discussed, including vinyl (various functional poly(styrene-co-divinylbenzene) and perfluorinated functionalized hydrocarbons, e.g., Nafion), condensation (polyesters, -amides, -anilines, -imides), and additional (polyurethanes, and polyureas, polybenzimidazoles, polyporphyrins), prepared from organometal monomers. Covalent organic frameworks (COFs), metal–organic frameworks (MOFs), and their composites represent a significant class of OMOP catalysts. Following this, the preparation, characterization, and application of dispersed metal catalysts are discussed. Key catalytic processes such as alkylation—used in large-scale applications like the production of alkyl-tert-butyl ether and bisphenol A—as well as reduction, oxidation, and other reactions, are highlighted. The versatile properties of COFs and MOFs, including well-defined nanometer-scale pores, large surface areas, and excellent chemisorption capabilities, make them highly promising for chemical, electrochemical, and photocatalytic applications. Particular emphasis is placed on their potential for CO2 treatment. However, a notable drawback of COF- and MOF-based catalysts is their relatively low stability in both alkaline and acidic environments, as well as their high cost. A special part is devoted to deactivation and the disposal of the used/deactivated catalysts, emphasizing the importance of separating heavy metals from catalysts. The conclusion provides guidance on selecting and developing OMOP-based catalysts.
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- 2024
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7. Development of a bifunctional nanobiosensor for screening and detection of chemokine ligand in colorectal cancer cell line
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Saeromi Chung, Yoon-Bo Shim, Pranjal Chandra, and Jaseok Peter Koo
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Models, Molecular ,Chemokine CXCL5 ,Biomedical Engineering ,Biophysics ,Analytical chemistry ,Metal Nanoparticles ,Biosensing Techniques ,02 engineering and technology ,Ligands ,01 natural sciences ,Receptors, Interleukin-8B ,chemistry.chemical_compound ,Limit of Detection ,Cell Line, Tumor ,Electrochemistry ,Humans ,CXC chemokine receptors ,Bifunctional ,Voltammetry ,Detection limit ,Chromatography ,010401 analytical chemistry ,Reproducibility of Results ,General Medicine ,021001 nanoscience & nanotechnology ,Amperometry ,0104 chemical sciences ,Dielectric spectroscopy ,Immobilized Proteins ,chemistry ,Colloidal gold ,Gold ,Colorectal Neoplasms ,0210 nano-technology ,Biosensor ,Biotechnology - Abstract
Highly sensitive detection of chemokines in various biological matrices and its interaction with a natural receptor molecule has tremendous importance in cell signaling, medical diagnostics, and therapeutics. In this direction, we have designed the first bifunctional nanobiosensor for chemokine screening and detection in a single experimental setting. The sensor probe was fabricated by immobilizing CXCR2 on the gold nanoparticles (AuNPs) deposited 2,2':5',2''-terthiophene-3' (p-benzoic acid) (TBA) nanocomposite film. The interaction between CXCR2 and chemokines was studied using electrochemical impedance spectroscopy (EIS) and voltammetry. CXCL5 among three ligands showed the strongest affinity to CXCR2, which was further utilized to develop an amperometric CXCL5 biosensor. Analytical parameters, such as CXCR2 receptor concentration, temperature, pH, and incubation time were optimized to obtain the high sensitivity. A dynamic range for CXCL5 detection was obtained between 0.1 and 10ng/mL with the detection limit of 0.078 ± 0.004ng/mL (RSD < 4.7%). The proposed biosensor was successfully applied to detect CXCL5 in clinically relevant concentrations in human serum and colorectal cancer cells samples with high sensitivity and selectivity. Interference effect and the stability of the developed biosensor were also evaluated. Method verification was performed by comparing the results using commercially available ELISA kit for CXCL5 detection.
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- 2018
8. Recent Advances in the Research on Luotonins A, B, and E
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Ján Gettler, Martin Markovič, Peter Koóš, and Tibor Gracza
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luotonins A, B, E ,quinolinopyrroloquinazoline ,alkaloids ,cytotoxicity ,biological activity ,Organic chemistry ,QD241-441 - Abstract
This digest review summarises the most recent progress in the study on luotonins A, B and E. The literature covered in this overview spans from January 2012 to April 2024 and presents synthetic methodologies for the assembly of the quinolinopyrrolo-quinazoline scaffold, the structural motifs present in luotonins A, B, and E, and the evaluation of the biological activities of their derivatives and structural analogues.
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- 2024
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9. Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects
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Katie L. Ayers, Stefanie Eggers, Ben N. Rollo, Katherine R. Smith, Nadia M. Davidson, Nicole A. Siddall, Liang Zhao, Josephine Bowles, Karin Weiss, Ginevra Zanni, Lydie Burglen, Shay Ben-Shachar, Jenny Rosensaft, Annick Raas-Rothschild, Anne Jørgensen, Ralf B. Schittenhelm, Cheng Huang, Gorjana Robevska, Jocelyn van den Bergen, Franca Casagranda, Justyna Cyza, Svenja Pachernegg, David K. Wright, Melanie Bahlo, Alicia Oshlack, Terrence J. O’Brien, Patrick Kwan, Peter Koopman, Gary R. Hime, Nadine Girard, Chen Hoffmann, Yuval Shilon, Amnon Zung, Enrico Bertini, Mathieu Milh, Bochra Ben Rhouma, Neila Belguith, Anu Bashamboo, Kenneth McElreavey, Ehud Banne, Naomi Weintrob, Bruria BenZeev, and Andrew H. Sinclair
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Science - Abstract
Abstract Squamous cell carcinoma antigen recognized by T cells 3 (SART3) is an RNA-binding protein with numerous biological functions including recycling small nuclear RNAs to the spliceosome. Here, we identify recessive variants in SART3 in nine individuals presenting with intellectual disability, global developmental delay and a subset of brain anomalies, together with gonadal dysgenesis in 46,XY individuals. Knockdown of the Drosophila orthologue of SART3 reveals a conserved role in testicular and neuronal development. Human induced pluripotent stem cells carrying patient variants in SART3 show disruption to multiple signalling pathways, upregulation of spliceosome components and demonstrate aberrant gonadal and neuronal differentiation in vitro. Collectively, these findings suggest that bi-allelic SART3 variants underlie a spliceosomopathy which we tentatively propose be termed INDYGON syndrome (Intellectual disability, Neurodevelopmental defects and Developmental delay with 46,XY GONadal dysgenesis). Our findings will enable additional diagnoses and improved outcomes for individuals born with this condition.
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- 2023
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10. Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
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Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril AB Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, Jason S Carroll, Timothy L Bailey, Peter Koopman, Ralf Jauch, Matthew A Cooper, Yann Gambin, and Mathias Francois
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Medicine ,Science ,Biology (General) ,QH301-705.5 - Published
- 2023
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11. Abstract 3334: CREB is required for KRAS-driven lung tumorigenesis
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Jong Woo Lee, Eric J. Nestler, Frank J. Slack, Jaseok Peter Koo, and Roy S. Herbst
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Cancer Research ,biology ,business.industry ,Transgene ,Response element ,Cancer ,medicine.disease ,medicine.disease_cause ,CREB ,respiratory tract diseases ,Oncology ,Cancer research ,biology.protein ,Medicine ,KRAS ,business ,Carcinogenesis ,Lung cancer ,Transcription factor - Abstract
The aberrant constitutive activation of the transcription factor, cyclic-AMP response element- binding (CREB) protein, has been associated with poor prognosis and chemotherapeutic resistance in KRAS-mutated human cancers, one of which includes non-small cell lung cancer (NSCLC). However, the role of CREB in KRAS-driven lung tumorigenesis has not been fully understood. Using adenoviral delivery of Cre specifically to the mouse lung, we generated a new transgenic lung cancer mouse model driven by Kras activating mutation G12D and concomitant with Creb loss (KrasLSL-G12D/+; CrebFlox/Flox). In this study, we used this model to show that a proto-oncogenic transcription factor CREB, is required for KRAS-driven lung tumorigenesis. Loss of Creb (Creb-/-) in the mice harboring Kras-mutated lung tumors significantly suppressed tumor development, and thus, dramatically prolonged mouse survival when compared to either wild (Creb+/+) or heterozygous (Creb+/-) deletion of Creb. Mechanistically, we identified a few novel CREB target gene. These data suggest that CREB is essential for KRAS-driven lung tumorigenesis and that CREB could be a potential target for therapeutic treatment for individuals suffering from KRAS-mutant lung cancers. Citation Format: Jong woo Lee, Frank J. Slack, Eric J. Nestler, Roy S. Herbst, Jaseok Peter Koo. CREB is required for KRAS-driven lung tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3334.
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- 2018
12. The use of a responder analysis to identify differences in patient outcomes following a self-care intervention to improve cancer pain management
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Steven M. Paul, Karen L. Schumacher, Marylin J. Dodd, Peter Koo, Claudia West, Debu Tripathy, and Christine Miaskowski
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Male ,medicine.medical_specialty ,Time Factors ,Pain ,Profile of mood states ,Article ,law.invention ,Randomized controlled trial ,Quality of life ,law ,Neoplasms ,Surveys and Questionnaires ,Intervention (counseling) ,Outcome Assessment, Health Care ,medicine ,Humans ,Pain Management ,Brief Pain Inventory ,Aged ,Chi-Square Distribution ,Cognitive Behavioral Therapy ,business.industry ,Middle Aged ,Self Care ,Clinical trial ,Affect ,Anesthesiology and Pain Medicine ,Mood ,Neurology ,Case-Control Studies ,Quality of Life ,Physical therapy ,Patient Compliance ,Female ,Neurology (clinical) ,Cancer pain ,business - Abstract
Previously, we demonstrated, in a randomized clinical trial, the effectiveness of a psychoeducational intervention to decrease pain intensity scores and increase patients' knowledge of cancer pain management with a sample of oncology patients with pain from bone metastasis. In the present study, we evaluated for changes in mood states (measured using the Profile of Mood States), quality of life (QOL; measured using the Medical Outcomes Study Short Form-36 (SF-36)), and pain's level of interference with function (measured using the Brief Pain Inventory (BPI)) from baseline to the end of the intervention first between the intervention and the standard care groups and then within the intervention group based on the patients' level of response to the intervention (i.e., patients were classified as non-responders, partial responders, or responders). No differences were found in any of these outcome measures between patients in the standard care and intervention groups. However, when patients in the intervention group were categorized using a responder analysis approach, significant differences in the various outcome measures were found among the three respondent groups. Differences in the physical and mental component summary scores on the SF-36 and the interference items on the BPI, among the three respondent groups, were not only statistically significant but also clinically significant. The use of responder analysis in analgesic trials may help to identify unique subgroups of patients and lead to the development of more effective psychoeducational interventions.
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- 2007
13. Taxonomic notes on the genus Phrynarachne from China (Araneae, Thomisidae)
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Yejie Lin, Long Yu, Peter Koomen, Xunyou Yan, and Shuqiang Li
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Zoology ,QL1-991 - Abstract
Four new species of the genus Phrynarachne Thorell, 1869 from China are described: P. dreepy Lin & S. Li, sp. nov. (♂♀), P. xuxiake Lin & S. Li, sp. nov. (♀), P. yunhui Lin & S. Li, sp. nov. (♀), and P. zhengzhongi Lin & S. Li, sp. nov. (♀). The unknown sexes of P. brevis Tang & S. Li, 2010 (♂), P. huangshanensis Li et al., 1985 (♀), P. lancea Tang & S. Li, 2010 (♂), and P. mammillata Song, 1990 (♀) are described for the first time. Phrynarachne sinensis Peng, Yin & Kim is treated as a nomen dubium.
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- 2022
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14. Postoperative pain management with a patient-controlled transdermal delivery system for fentanyl
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Peter Koo
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medicine.medical_specialty ,Skin Absorption ,Postoperative pain ,Analgesic ,Absorption (skin) ,Administration, Cutaneous ,Placebo ,Fentanyl ,Humans ,Medicine ,health care economics and organizations ,Transdermal ,Postoperative Care ,Pharmacology ,Clinical Trials as Topic ,Pain, Postoperative ,business.industry ,Health Policy ,Chronic pain ,Analgesia, Patient-Controlled ,Iontophoresis ,medicine.disease ,Surgery ,Analgesics, Opioid ,Anesthesia ,Morphine ,business ,medicine.drug - Abstract
Purpose. The efficacy and safety of fentanyl hydrochloride patient-controlled trans-dermal system (PCTS) for management of acute postoperative pain are discussed. Summary. Fentanyl hydrochloride PCTS is a self-contained, needle-free, credit-card-sized fentanyl-delivery system that is worn on the patient’s arm or chest. The system uses iontophoretic technology to actively deliver preprogrammed doses of fentanyl into the systemic circulation when activated by the patient on demand. PCTS is as safe and effective as i.v. morphine patient-controlled analgesia and superior to placebo for managing acute postoperative pain. Fentanyl absorption from PCTS is clinically insignificant when the device is not activated. This contrasts with the transdermal fentanyl patch, which delivers fentanyl continuously for 72 hours via passive absorption and is indicated only for use in the management of chronic pain. Conclusion. Fentanyl hydrochloride PCTS is a self-contained iontophoretic fentanyl-delivery system that provides patients control over pain management and consistent management of pain without analgesic peaks and troughs.
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- 2005
15. Qualitative research contribution to a randomized clinical trial
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Marylin J. Dodd, Claudia West, Debasish Tripathy, Christine Miaskowski, Steven M. Paul, Karen L. Schumacher, Setsuko Koresawa, and Peter Koo
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Protocol (science) ,medicine.medical_specialty ,business.industry ,Alternative medicine ,Pain ,Nursing Methodology Research ,Coaching ,Medical Records ,law.invention ,Clinical trial ,Patient Education as Topic ,Randomized controlled trial ,Research Design ,law ,Tape Recording ,Intervention (counseling) ,Physical therapy ,Humans ,Medicine ,business ,Cancer pain ,Qualitative Research ,General Nursing ,Randomized Controlled Trials as Topic ,Qualitative research - Abstract
Qualitative research may be combined fruitfully with intervention studies, but few examples provide detailed methodological strategies for doing so. In this article, we describe the qualitative component of a randomized clinical trial (RCT) of the PRO-SELF© Pain Control Program, an intervention that provides individualized education, coaching, and support for cancer pain management. We conducted three qualitative analyses of verbatim transcripts of “real-time” audiotaped intervention sessions. As a result, we were better able to ascertain the nature of the individualized coaching component of the intervention, patient and family caregiver use of selected intervention tools, and reasons the intervention did not work for some patients. Study results were used to increase the specificity with which the coaching portion of the intervention is described in the intervention protocol. © 2005 Wiley Periodicals, Inc. Res Nurs Health 28: 268–280, 2005
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- 2005
16. No evidence for sex differences in the severity and treatment of cancer pain
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Karen L. Schumacher, Janet Edrington, Peter Koo, Marylin Dodd, Steven M. Paul, Debasish Tripathy, Noreen C. Facione, Claudia West, and Christine Miaskowski
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Male ,medicine.medical_specialty ,Analgesic ,Pain ,Bone Neoplasms ,Severity of Illness Index ,Sex Factors ,Internal medicine ,Severity of illness ,medicine ,Humans ,Medical prescription ,General Nursing ,Aged ,Pain Measurement ,Analgesics ,business.industry ,Chronic pain ,Cancer ,Bone metastasis ,Middle Aged ,medicine.disease ,Sexual dimorphism ,Anesthesiology and Pain Medicine ,Physical therapy ,Female ,Neurology (clinical) ,Cancer pain ,business - Abstract
While chronic pain is experienced by approximately 50-90% of patients with metastatic cancer, little is known about sex differences in chronic cancer pain. Therefore, the purposes of this study, in a sample of oncology outpatients (n=187) who were experiencing pain from bone metastasis, were: 1) to determine if there were sex differences in various pain characteristics, including pain intensity, and 2) to determine if there were sex differences in the prescription and consumption of analgesic medications. No significant sex differences were found in any of the baseline pain characteristics. In addition, no significant sex differences were found in analgesic prescriptions or intake of analgesic medications. Of note, men reported significantly higher pain interference scores for sexual activity than women. The study findings are important because they suggest that, unlike in acute pain, sex may not influence patients' perceptions of and responses to chronic cancer pain.
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- 2004
17. Randomized Clinical Trial of the Effectiveness of a Self-Care Intervention to Improve Cancer Pain Management
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Marylin J. Dodd, Steven M. Paul, Claudia West, Christine Miaskowski, Debasish Tripathy, Karen L. Schumacher, and Peter Koo
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Male ,Cancer Research ,medicine.medical_specialty ,Analgesic ,MEDLINE ,Pain ,Bone Neoplasms ,law.invention ,Patient Education as Topic ,Randomized controlled trial ,law ,Intervention (counseling) ,Humans ,Pain Management ,Medicine ,Medical prescription ,Aged ,Pain Measurement ,Analgesics ,business.industry ,Communication ,Bone metastasis ,Middle Aged ,medicine.disease ,Self Care ,Clinical trial ,Treatment Outcome ,Oncology ,Physical therapy ,Patient Compliance ,Female ,Nurse-Patient Relations ,business ,Cancer pain - Abstract
Purpose This randomized clinical trial tested the effectiveness of the PRO-SELF Pain Control Program compared with standard care in decreasing pain intensity scores, increasing appropriate analgesic prescriptions, and increasing analgesic intake in oncology outpatients with pain from bone metastasis. Patients and Methods Patients were randomly assigned to the PRO-SELF intervention (n = 93) or standard care (n = 81). Patients in the standard care arm were seen by a research nurse three times and were called three times by phone between the home visits. PRO-SELF group patients were seen by specially trained intervention nurses and received a psychoeducational intervention, were taught how to use a pillbox, and were given written instructions on how to communicate with their physician about unrelieved pain and the need for changes in their analgesic prescriptions. Patients were coached during two follow-up home visits and three phone calls on how to improve their cancer pain management. Results Pain intensity scores decreased significantly from baseline (all P < .0001) in the PRO-SELF group (ie, least pain, 28.4%; average pain, 32.5%; and worst pain, 27.0%) compared with the standard care group (ie, least increased by 14.6%, average increased by 1.9%, and worst decreased by 1.2%). The percentage of patients in the PRO-SELF group with the most appropriate type of analgesic prescription increased significantly from 28.3% to 37.0% (P = .008) compared with a change from 29.6% to 32.5% in the standard care group. Conclusion The use of a psychoeducational intervention that incorporates nurse coaching within the framework of self-care can improve the management of cancer pain.
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- 2004
18. The PRO-SELF©: Pain Control Program—An Effective Approach for Cancer Pain Management
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Claudia West, Karen L. Schumacher, Christine Miaskowski, Debasish Tripathy, Steven M. Paul, M. Dodd, and Peter Koo
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Program evaluation ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,MEDLINE ,Pain ,Coaching ,Academic detailing ,Quality of life (healthcare) ,Patient Education as Topic ,Nursing ,Neoplasms ,Humans ,Medicine ,Aged ,Analgesics ,business.industry ,Family caregivers ,Videotape Recording ,Cancer ,medicine.disease ,Community-Institutional Relations ,Self Care ,Caregivers ,Family medicine ,business ,Cancer pain ,Program Evaluation - Abstract
PURPOSE/OBJECTIVES: To describe the PRO-SELF(c): Pain Control Program, an educational approach that provides patients and family caregivers with the knowledge, skills, and nursing support needed to improve pain relief. DATA SOURCES: Published research studies, articles, and conference abstracts. DATA SYNTHESIS: Patients with cancer and family caregivers lack knowledge about pain management and side effects. Engaging in self-care behaviors improves patients' health outcomes. CONCLUSIONS: The PRO-SELF: Pain Control Program is an effective approach that can be used to help patients with cancer and their family caregivers obtain the knowledge and skills that are needed to manage pain. Three key strategies for delivering the PRO-SELF program are (a) provision of information using academic detailing, (b) skill building with ongoing nurse coaching, and (c) interactive nursing support. IMPLICATIONS FOR NURSING: Adequate pain relief is vital to decreasing cancer morbidity and improving patients' quality of life. The PRO-SELF: Pain Control Program should be implemented in all settings where cancer care takes place.
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- 2003
19. Putting Cancer Pain Management Regimens into Practice at Home
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Marylin J. Dodd, Claudia West, Christopher Hawkins, Christine Miaskowski, Debu Tripathy, Evalyn Wais, Karen L. Schumacher, Setsuko Koresawa, Peter Koo, Carol Johnson, and Steven M. Paul
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Male ,medicine.medical_specialty ,MEDLINE ,Pain ,Coaching ,law.invention ,Randomized controlled trial ,law ,Neoplasms ,Intervention (counseling) ,medicine ,Humans ,Pain Management ,General Nursing ,Aged ,business.industry ,Family caregivers ,Palliative Care ,Middle Aged ,Home Care Services ,Clinical trial ,Regimen ,Anesthesiology and Pain Medicine ,Physical therapy ,Female ,Neurology (clinical) ,business ,Cancer pain - Abstract
The purpose of this study was to describe the difficulties with pain management that patients and family caregivers bring to a nurse's attention during a teaching and coaching intervention. Data were obtained from audiotaped and transcribed interactions between intervention nurses and patients (n = 52) and their family caregivers (n = 33) who were participating in a randomized clinical trial of a nursing intervention called the PRO-SELF Copyright Pain Control Program. Using qualitative content analysis, we found that patients had difficulty in seven areas when they attempted to put a pain management regimen into practice, namely: obtaining the prescribed medication(s), accessing information, tailoring prescribed regimens to meet individual needs, managing side effects, cognitively processing information, managing new or unusual pain, and managing multiple symptoms simultaneously. The findings from this study suggest that the provision of information about cancer pain management to patients and their family caregivers is not sufficient to improve pain control in the home care setting. Patients and their family caregivers require ongoing assistance with problem-solving to optimize their pain management regimen.
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- 2002
20. Oncology outpatients with pain from bone metastasis require more than around-the-clock dosing of analgesics to achieve adequate pain control
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Peter Koo, Marylin Dodd, Debu Tripathy, Kayee Alice Mack, Noreen C. Facione, Claudia West, Karen L. Schumacher, Christine Miaskowski, and Steven M. Paul
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Oncology ,medicine.medical_specialty ,business.industry ,Analgesic ,Bone metastasis ,medicine.disease ,Anesthesiology and Pain Medicine ,Neurology ,Opioid ,Pain control ,Prescription opioid ,Internal medicine ,medicine ,Physical therapy ,Neurology (clinical) ,Dosing ,Opioid analgesics ,Cancer pain ,business ,medicine.drug - Abstract
Around-the-clock (ATC) dosing of opioid analgesics is the established approach for the management of chronic cancer pain. The purposes of this study were to determine whether there were differences in pain intensity scores and pain duration between oncology outpatients who were taking opioid analgesics on an around-the-clock (ATC) compared with an as needed (PRN) basis and to determine differences in opioid prescription and consumption between the 2 groups during a period of 5 weeks. Oncology patients (n = 137) with pain from bone metastasis were recruited from 7 outpatient settings. Patients completed a demographic questionnaire and on a daily basis recorded pain intensity scores and medication intake in a diary. No significant differences in average, least, or worst pain intensity scores or number of hours per day in pain were found between the 2 groups. However, the average total opioid dose, prescribed and taken, was significantly greater for the ATC group than for the PRN group. These findings suggest the need for further investigations in the following areas: the appropriate treatments for pain related to bone metastasis, the use of various pain measures to evaluate the effectiveness of analgesic medications, and the need to evaluate how analgesics are prescribed and titrated for patients with cancer-related pain. © 2002 by the American Pain Society
- Published
- 2002
21. The Usefulness of a Daily Pain Management Diary for Outpatients With Cancer-Related Pain
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Peter Koo, Setsuko Koresawa, Steven M. Paul, M. Dodd, Karen L. Schumacher, Claudia West, Christine Miaskowski, and Debasish Tripathy
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Adult ,Male ,Research design ,medicine.medical_specialty ,Health Behavior ,Pain ,Bone Neoplasms ,Coaching ,Medical Records ,Clinical Nursing Research ,law.invention ,Randomized controlled trial ,law ,Surveys and Questionnaires ,Intervention (counseling) ,Outpatients ,Humans ,Medicine ,Internal-External Control ,Aged ,business.industry ,Family caregivers ,Medical record ,Oncology Nursing ,Middle Aged ,Self Care ,Clinical trial ,Oncology nursing ,Caregivers ,Research Design ,Physical therapy ,Female ,business - Abstract
Purpose/objectives To describe the usefulness of daily pain management diaries to outpatients with cancer who participated in a randomized clinical trial of the PRO-SELF Pain Control Program. Design Randomized clinical trial in which a daily pain management diary was used for data collection in the control group and for data collection and nurse coaching regarding the pain management program in the intervention group. Setting Seven outpatient oncology settings. Sample 155 patients with pain from bone metastases and 90 family caregivers. Methods Content and statistical analysis of audiotaped answers to a semistructured questionnaire. Main research variables Patients' and family caregivers' perceptions of the usefulness of a daily pain management diary; specific ways in which the diary was used. Findings Patients in both the intervention (75%) and control groups (73%) found the diary useful. The diary was used to heighten awareness of pain, guide pain management behavior, enhance a sense of control, and facilitate communication. Family caregivers in both groups also reported that the diary was useful. Conclusions The completion of a daily pain management diary is useful to patients and family caregivers and may function as an intervention for self-care. Implications for nursing Research-based evidence supports the importance of using a daily pain management diary in clinical practice.
- Published
- 2002
22. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma
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Jong Woo Lee, Jaseok Peter Koo, Janaki Parameswaran, Teresa Sandoval-Schaefer, and Barbara Burtness
- Subjects
0301 basic medicine ,Response rate (survey) ,Cancer Research ,Poor prognosis ,biology ,business.industry ,medicine.disease ,Head and neck squamous-cell carcinoma ,03 medical and health sciences ,Wee1 ,030104 developmental biology ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,HPV Negative ,Cancer research ,biology.protein ,Medicine ,Aurora Kinase A ,business - Abstract
e14105 Background: Aurora Kinase A (AURKA) is overexpressed in HNSCC, and correlates with poor prognosis. It has been identified as a potential therapeutic target, yet the response rate for the AURKA inhibitor MLN8237 is only 9% in treatment refractory HNSCC. We hypothesized that although AURKA inhibitors lead to defective spindle assembly, they may also reduce mitotic entry, undermining cytotoxic effect. We predicted that adding a WEE1 inhibitor to an AURKA inhibitor would mitigate this effect and enhance cell death Methods: Cell viability assays were performed on FaDu ( p53 mut.), Detroit562 ( p53 mut.), and UNC7 ( p53 WT) HPV negative HNSCC cell lines treated with AZD1775 (AZD), MLN8237 (MLN), and combination of AZD+MLN. Oncosphere formation assays were used to confirm findings of cell death, and western blot analysis and confocal microscopy were used to investigate mechanism of synergy. The above drugs were also given at varying doses via oral gavage to FaDu xenografted nude mice. Results: There was clear synergy of AZD and MLN in-vitro. Combination Indices were determined by the Chou-Talalay method: FaDu 0.4, Detroit562 0.5, and UNC7 0.6 (synergy = < 0.8). Oncopshere assays showed inability of AZD+MLN treated cells to re-differentiate. FaDu cells treated with MLN had increased p-CDK1 and reduced phospho-histone H3 (pHH3), suggesting reduced mitotic entry. AZD+MLN treated cells had reduced p-CDK1 and increased pHH3, similar to AZD treated cells; they also had spindle disarray with poor chromatin organization on confocal microscopy indicating mitotic catastrophe. In mice, the combination of AZD+MLN inhibited tumor growth, with no apparent toxicity. Mice treated with either drug alone had tumor volumes over 1000mm3 and were sacrificed at day 21; those treated with AZD 90mg/kg and MLN 30mg/kg had tumors volumes around 300mm3 on day 28. Conclusions: AZD and MLN synergistically enhance cell death in HNSCC cell lines and significantly inhibit tumor growth in mouse xenograft models. The ability of AZD to overcome intrinsic resistance to MLN may underlie mechanism of synergy. We recommend further investigation of AURKA and WEE1 inhibition in other cancers with high AURKA expression, and in patients with HNSCC.
- Published
- 2017
23. P3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model
- Author
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Justin J Choi, Yu Zhang, Jong Woo Lee, Vassiliki A. Papadimitrakopoulou, Hee Sun Park, Roy S. Herbst, Roshan Sharma, J. Peter Koo, and Edward Kaftan
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,business.industry ,MEK inhibitor ,Mutant ,Pharmacology ,medicine.disease_cause ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Animal model ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Medicine ,KRAS ,Combination immunotherapy ,business ,Lung cancer - Published
- 2017
24. Lack of Adherence With the Analgesic Regimen: A Significant Barrier to Effective Cancer Pain Management
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Peter Koo, Debu Tripathy, Steven M. Paul, Claudia West, Christine Miaskowski, Karen L. Schumacher, and Marylin J. Dodd
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Cancer Research ,Longitudinal study ,medicine.medical_specialty ,Karnofsky Performance Status ,business.industry ,Analgesic ,Bone metastasis ,medicine.disease ,Poor adherence ,Regimen ,Oncology ,Internal medicine ,Physical therapy ,Medicine ,business ,Opioid analgesics ,Cancer pain - Abstract
PURPOSE: To evaluate oncology outpatients’ level of adherence to their analgesic regimen during a 5-week period. PATIENTS AND METHODS: A random sample of 65 adult oncology outpatients with a Karnofsky performance status score of ≥ 50, an average pain intensity score of ≥ 2.5, and radiographic evidence of bone metastasis were recruited for this longitudinal study from seven outpatient settings. On a daily basis, patients rated their level of pain intensity and recorded pain medication intake. Adherence rates for opioid analgesics prescribed on an around-the-clock (ATC) and on an as-needed (PRN) basis were calculated on a weekly basis. RESULTS: Overall adherence rates for ATC opioid analgesics ranged from 84.5% to 90.8% and, for PRN analgesics, from 22.2% to 26.6%. No significant differences over time were found in either of these adherence rates. CONCLUSION: One factor that seems to contribute to ineffective cancer pain management is poor adherence to the analgesic regimen.
- Published
- 2001
25. Synthetic Study of Natural Metabolites Containing a Benzo[c]oxepine Skeleton: Heterocornol C and D
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Ján Gettler, Tomáš Čarný, Martin Markovič, Peter Koóš, Erika Samoľová, Ján Moncoľ, and Tibor Gracza
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heterocornol ,polyketide ,benzo[c]oxepin-1-one ,natural compound ,asymmetric synthesis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
A versatile strategy for the enantioselective synthesis of a benzo[c]oxepine structural core containing natural secondary metabolites was developed. The key steps of the synthetic approach include ring-closing alkene metathesis for seven-member ring construction, the Suzuki–Miyaura cross-coupling reaction for the installation of the double bond and Katsuki–Sharpless asymmetric epoxidation for the introduction of chiral centers. The first total synthesis and absolute configuration assignment of heterocornol D (3a) were achieved. Four stereoisomers, 3a, ent-3a, 3b and ent-3b, of this natural polyketide were prepared, starting with 2,6-dihydroxy benzoic acid and divinyl carbinol. The absolute and relative configuration of heterocornol D was assigned via single-crystal X-ray analysis. The extension of the described synthetic approach is further presented with the synthesis of heterocornol C by applying the ether group reduction method to the lactone.
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- 2023
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26. Author Correction: Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects
- Author
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Katie L. Ayers, Stefanie Eggers, Ben N. Rollo, Katherine R. Smith, Nadia M. Davidson, Nicole A. Siddall, Liang Zhao, Josephine Bowles, Karin Weiss, Ginevra Zanni, Lydie Burglen, Shay Ben-Shachar, Jenny Rosensaft, Annick Raas-Rothschild, Anne Jørgensen, Ralf B. Schittenhelm, Cheng Huang, Gorjana Robevska, Jocelyn van den Bergen, Franca Casagranda, Justyna Cyza, Svenja Pachernegg, David K. Wright, Melanie Bahlo, Alicia Oshlack, Terrence J. O’Brien, Patrick Kwan, Peter Koopman, Gary R. Hime, Nadine Girard, Chen Hoffmann, Yuval Shilon, Amnon Zung, Enrico Bertini, Mathieu Milh, Bochra Ben Rhouma, Neila Belguith, Anu Bashamboo, Kenneth McElreavey, Ehud Banne, Naomi Weintrob, Bruria BenZeev, and Andrew H. Sinclair
- Subjects
Science - Published
- 2023
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27. Abstract 2334: Anti-cancer efficacy of the combination with immunomodulatory antibodies and MEK inhibitor for Kras mutation and p53 knockout driven lung cancer
- Author
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Jong Woo Lee, Jaseok Peter Koo, Yu Zhang, Hee Sun Park, Sin-Aye Park, and Roy S. Herbst
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0301 basic medicine ,Cancer Research ,medicine.medical_treatment ,Melanoma ,MEK inhibitor ,Cancer ,Immunotherapy ,Biology ,medicine.disease ,medicine.disease_cause ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Immune system ,Oncology ,030220 oncology & carcinogenesis ,Immunology ,medicine ,biology.protein ,KRAS ,Antibody ,Lung cancer - Abstract
Lung cancer remains a major cause of cancer mortality. Malignant lesions are normally endogenously corrected by the immune surveillance system. However, tumors evade this immunity by inducing immunosuppressive microenvironments during cancer progression. It has been thought that there are two critical components of tumors making them capable of maintaining the immunosuppressive microenvironment. One is the inhibition of cytotoxic T lymphocytes (CTL) activity against the tumor through immune checkpoint molecules, such as programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1), which are negative regulators of CTL, and the other is by the induction of tumor infiltrating immune suppressive cells, which can deactivate the CTL. Recent studies demonstrate that multiple cancer types, including melanoma, lung, kidney, bladder, and stomach, respond to immune checkpoint inhibitors, such as PD-L1 and PD-1 with 11-30% response rates and durable responses. However, a substantial number of patients still fail to respond to immunotherapy and the refractory mechanisms are largely unknown. In this study, we focus on KRas-driven lung cancers, as there are no clinically effective targeted drugs available for treating this type of lung cancer. We demonstrate that during the progression of tumors in KRas mutation and p53 knockout-driven lung cancer mouse models; KRasG12D/+;p53-/- (KP), there is a gradual increase in the number of myeloid derived suppressor cells (MDSC) and that the combination of either anti-PD-1 or anti-PD-L1 antibody along with a MEK inhibitor, which targets downstream of KRas signaling, shows anticancer efficacy in these animal models. These combinations, in comparison to either single agent alone, effectively blocks the growth of subcutaneously (s.c.) injected syngeneic mouse lung cancer cells in immune competent transgenic KP mice, significantly increasing the survival rates: 37.5% (for anti-PD-1 antibody and MEK inhibitor), 62.5% (for anti-PD-L1 antibody and MEK inhibitor) vs. 0% single agents or control at the end of treatment. We find that the tumors in the control treated group harbor a substantial number of immune cells, including PD-L1 expressing MDSC. The combination treatment with either an anti-PD-1 or anti-PD-L1 antibody along with a MEK inhibitor dramatically modulates the composition and the activity of tumor infiltrated immune cells. Tumors in the combined treated group show a significant decrease in PD-L1 expressing MDSC in comparison with control tumors. Additionally, a combined treatment would block the PD-L1 activity of the infiltrated PD-L1 expressing MDSC in malignant tumors and thus lead to improved survival. These results point to a potential therapeutic opportunity for currently untargetable KRas-driven lung cancers. Citation Format: Jong Woo Lee, Yu Zhang, Hee Sun Park, Sin Aye Park, JaSeok Peter Koo, Roy S. Herbst. Anti-cancer efficacy of the combination with immunomodulatory antibodies and MEK inhibitor for Kras mutation and p53 knockout driven lung cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2334.
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- 2016
28. Addressing stakeholders' needs: economics and patient satisfaction
- Author
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Peter Koo
- Subjects
medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,MEDLINE ,Pharmacy ,Injections, Intramuscular ,Patient Readmission ,Drug Costs ,Patient satisfaction ,Medicine ,Humans ,Medication Errors ,Surgical treatment ,Intensive care medicine ,Pharmacology ,Analgesics ,Pain, Postoperative ,business.industry ,Patient-controlled analgesia ,Health Policy ,Analgesia, Patient-Controlled ,Pain management ,Length of Stay ,Analgesia, Epidural ,Cost driver ,Patient Satisfaction ,Injections, Intravenous ,Physical therapy ,Staff time ,business ,Pharmacy Service, Hospital - Abstract
Purpose. The economics of acute post-operative pain management are discussed. Studies identifying cost drivers in post-operative pain treatment and the economic sequelae of undertreated pain are reviewed. The relative costs of intermittent intramuscular analgesia, intravenous patient-controlled analgesia, and epidural analgesia are described. Medication errors and their consequences are addressed. The importance of patient satisfaction and data on its correlation with acute post-operative pain are reviewed. Summary. Although the economics of acute post-operative pain treatment are difficult to accurately assess, studies have demonstrated that pharmacy acquisition costs represent as little as 1% of the total hospital cost of surgical treatment. Costs of analgesia are driven largely by staff time. Inadequate treatment of post-operative pain can have important economic ramifications associated with increased patient morbidity, extended hospital stays, and readmissions. Inadequate treatment of post-operative pain is also associated with reduced patient satisfaction, a measure of increasing importance to health systems and pharmacists who practice within them. Conclusion. Undertreatment of acute post-operative pain has important implications for health systems from the standpoints of economics and patient satisfaction.
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- 2007
29. Abstract 2094: GSK-3 is a novel target of CREB and GSK-3-CREB signaling participates in cell survival in lung cancer
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Jong Woo Lee, Sin-Aye Park, Jaseok Peter Koo, and Roy S. Herbst
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Cancer Research ,biology ,Cell growth ,Cellular differentiation ,Cancer ,CREB ,medicine.disease ,Metastasis ,Oncology ,GSK-3 ,biology.protein ,Cancer research ,medicine ,Lung cancer ,Transcription factor - Abstract
The transcription factor cyclic AMP-response element-binding protein (CREB) regulates diverse cellular processes, including cell differentiation, proliferation, survival, glucose metabolism, immune regulation, and synaptic plasticity associated with memory. Previously, we showed that CREB is critical on the regulation of mucous differentiation of normal human tracheobronchial epithelial (NHTBE) cells. In addition, the overexpression of CREB is associated with negative prognosis of patients with non-small cell lung cancer (NSCLC). Further studies showed that the knockdown of CREB suppresses the growth of lung cancer cells. It has been demonstrated that genes regulated by CREB have been reported to be involved in the suppression of apoptosis, induce cell proliferation, inflammation and tumor metastasis. However, the critical target genes of CREB in lung cancer have not been well understood. In this study, we identified GSK-3 as one of the CREB target genes critical for the growth and survival of lung cancer cells. The CREB knockdown significantly reduced the expression of GSK-3 and the direct binding of CREB on the promoter of GSK-3 was identified. Kaplan-Meier analysis with a public database showed a prognostic significance of aberrant GSK-3 expression in lung cancer. Inhibition of GSK-3 suppressed cell proliferation, colony formation and tumor growth. Although GSK-3 has been studied as a tumor suppressor in certain types of cancer, there is increasing evidence that GSK-3 plays an oncogenic role in various human cancers. Here, for the first time, we demonstrated that GSK-3 is regulated by CREB in lung cancer and is required for the survival of lung cancer cells. These findings implicate CREB-GSK-3 axis as a novel therapeutic target for lung cancer treatment. Citation Format: Sin-Aye Park, Jong Woo Lee, Roy S. Herbst, Jaseok Peter Koo. GSK-3 is a novel target of CREB and GSK-3-CREB signaling participates in cell survival in lung cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2094. doi:10.1158/1538-7445.AM2015-2094
- Published
- 2015
30. Abstract LB-092: Programmed death-ligand 1 is overexpressed in bronchial preneoplastic lesions: can it be a risk indicator
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Sun Young Kim, Bo Mi Park, Hee Sun Park, Jung Sung Soo, Chung Jae Uk, Ju Ock Kim, Jaseok Peter Koo, Dong Il Park, Choong Sik Lee, and Jae Young Moon
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Cancer Research ,Pathology ,medicine.medical_specialty ,Cancer prevention ,business.industry ,Cancer ,medicine.disease ,medicine.disease_cause ,Lesion ,Oncology ,Cancer research ,Carcinoma ,Medicine ,Cytotoxic T cell ,Adenocarcinoma ,medicine.symptom ,business ,Lung cancer ,Carcinogenesis - Abstract
Compared to the vigorous development of targeted drugs and some of them are already become one of the best treatment of choices in lung adenocarcinoma, squamous lung carcinoma has no definite targets and treatment outcome is not yet superior to lung adenocarcinoma. Demonstration of initial carcinogenesis is benefitial in two aspects: cancer prevention and development of its targets. Studying preneoplastic lesions of bronchus can answer those questions. Preneoplastic lesion, which is considered to have malignant potential, may develop into invasive cancer by escaping from host immune response. CD274 (programmed death-ligand 1, PD-L1) interacts with PD-1, is known to inhibit CD8+ cytotoxic T lymphocyte and induce apoptosis and, also to promote the differentiation of CD4+ T cells into regulatory T cells, so finally evade immune surveillance. We hypothesized that PD-L1 may work as an immune evader in preneoplastic lesion during its carcinogenesis. We performed white light and/or autofluorescence bronchoscopy in patients who have risk factor(s) of lung cancer or are suspected to have a lung cancer. Interestingly, PD-L1 was also overexpressed in preneoplastic lesions especially in severe dysplasia of the bronchus. This finding implies overexpression of PD-L1 can involve at early step of carcinogenesis. Further studies are needed to demonstrate the role of PD-L1 in preneoplastic bronchial lesion potential to develop invasive cancer. Citation Format: Hee Sun Park, Bo Mi Park, Dong Il Park, Chung Jae Uk, Jae Young Moon, Jung Sung Soo, Choong Sik Lee, Ju Ock Kim, Sun Young Kim, Jaseok Peter Koo. Programmed death-ligand 1 is overexpressed in bronchial preneoplastic lesions: can it be a risk indicator. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-092. doi:10.1158/1538-7445.AM2015-LB-092
- Published
- 2015
31. Differences in the prevalence and severity of side effects based on type of analgesic prescription in patients with chronic cancer pain
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Steven M. Paul, Theresa Koetters, Patrice Villars, Peter Koo, Karen L. Schumacher, Marylin J. Dodd, Claudia West, Christine Miaskowski, and Debasish Tripathy
- Subjects
Adult ,Male ,Nausea ,Analgesic ,Pain ,Severity of Illness Index ,Article ,Neoplasms ,Severity of illness ,Prevalence ,Medicine ,Humans ,Medical prescription ,Opioid peptide ,General Nursing ,Aged ,Analgesics ,business.industry ,Chronic pain ,Middle Aged ,medicine.disease ,Anesthesiology and Pain Medicine ,Opioid ,Anesthesia ,Chronic Disease ,Female ,Neurology (clinical) ,medicine.symptom ,Cancer pain ,business ,medicine.drug - Abstract
An understanding of the relationship between the type of analgesic prescription and the prevalence and severity of side effects is crucial in making appropriate treatment decisions. The purposes of this study were: to determine if there were differences in the prevalence of side effects among four different types of analgesic prescriptions (i.e., no opioid, only an as needed (PRN) opioid, only an around-the-clock (ATC) opioid, or an ATC + PRN opioid); to determine if there were differences in the severity of side effects among the four prescriptions groups; and to determine the relationships between the total dose of opioid analgesic medication prescribed and taken and the severity of side effects. As part of a larger study, 174 cancer patients with bone metastasis reported their analgesic use and the prevalence and severity of eleven side effects. Significant differences (P < 0.05) were found in prevalence rates for seven of the side effects among the four prescription groups. The highest prevalence rates were found in the only ATC and ATC + PRN groups. Significant differences were found in the severity scores for five of the side effects, with the highest severity scores reported by patients in the only ATC and ATC + PRN groups. Significant positive correlations were found between the severity of six of the side effects and the total dose of opioid prescribed and taken. Risk factors for analgesic-induced side effects are ATC and ATC + PRN prescription types and higher doses of opioid analgesics.
- Published
- 2006
32. The PRO-SELF pain control program improves patients' knowledge of cancer pain management
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Peter Koo, Claudia West, Christine Miaskowski, Debasish Tripathy, Jung Eun Kim, M. Dodd, Noreen C. Facione, Steven M. Paul, and Karen L. Schumacher
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Program evaluation ,Male ,medicine.medical_specialty ,Randomization ,business.industry ,MEDLINE ,Pain ,Middle Aged ,law.invention ,Clinical trial ,Randomized controlled trial ,Patient Education as Topic ,law ,Intervention (counseling) ,Neoplasms ,Physical therapy ,medicine ,Humans ,Pain Management ,Female ,Cancer pain ,business ,Patient education ,Pain Measurement ,Program Evaluation - Abstract
Purpose/objectives To evaluate the effectiveness of a psychoeducational program (i.e., PRO-SELF Pain Control Program) compared to standard care in increasing patients' knowledge regarding cancer pain management. Design Randomized clinical trial. Setting Seven outpatient settings in northern California. Sample 174 outpatients with cancer and pain from bone metastasis. Methods Following randomization into either the PRO-SELF or standard care group, patients completed the Pain Experience Scale (PES) prior to and at the completion of the intervention. Main research variables Total and individual item scores on the PES. Findings Total PES knowledge scores increased significantly in the PRO-SELF group (21%) compared to the standard care group (0.5%). Significant improvements in knowledge scores for patients in the PRO-SELF group were found on five of the nine PES items when compared to baseline scores. Conclusions The PRO-SELF Pain Control Program was an effective approach to increase patients' knowledge of cancer pain management. Implications for nursing The use of a structured paper-and-pencil questionnaire, such as the PES, as part of a psychoeducational intervention provides an effective foundation for patient education in cancer pain management. Oncology nurses can use patients' responses to this type of questionnaire to individualize the teaching and to spend more time on the identified knowledge deficits. This individualized approach to education about pain management may save staff time and improve patient outcomes.
- Published
- 2004
33. The impact of temperature and crystal orientation fabric on the dynamics of mountain glaciers and ice streams
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Kate Hruby, Christopher Gerbi, Peter Koons, Seth Campbell, Carlos Martín, and Robert Hawley
- Subjects
Anisotropic ice flow ,glacier flow ,glaciological model experiments ,ice rheology ,ice streams ,Environmental sciences ,GE1-350 ,Meteorology. Climatology ,QC851-999 - Abstract
Streaming ice accounts for a major fraction of global ice flux, yet we cannot yet fully explain the dominant controls on its kinematics. In this contribution, we use an anisotropic full-Stokes thermomechanical flow solver to characterize how mechanical anisotropy and temperature distribution affect ice flux. For the ice stream and glacier geometries we explored, we found that the ice flux increases 1–3% per °C temperature increase in the margin. Glaciers and ice streams with crystallographic fabric oriented approximately normal to the shear plane increase by comparable amounts: an otherwise isotropic ice stream containing a concentrated transverse single maximum fabric in the margin flows 15% faster than the reference case. Fabric and temperature variations independently impact ice flux, with slightly nonlinear interactions. We find that realistic variations in temperature and crystallographic fabric both affect ice flux to similar degrees, with the exact effect a function of the local fabric and temperature distributions. Given this sensitivity, direct field-based measurements and models incorporating additional factors, such as water content and temporal evolution, are essential for explaining and predicting streaming ice dynamics.
- Published
- 2020
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34. Craspedotropis gretathunbergae, a new species of Cyclophoridae (Gastropoda: Caenogastropoda), discovered and described on a field course to Kuala Belalong rainforest, Brunei
- Author
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Menno Schilthuizen, Jonathan Lim, Anthonie van Peursen, Massimiliano Alfano, Awang Bikas Jenging, Daniele Cicuzza, Alexandre Escoubas, Pierre Escoubas, Ulmar Grafe, Jamil Ja, Peter Koomen, Aleks Krotoski, Denise Lavezzari, Laura Lim, Rudie Maarschall, Ferry Slik, Derek Steele, Dennis Teck Wah Ting, Ine van Zeeland, and Iva Njunjić
- Subjects
Land snails ,Borneo ,lowland dipterocarp rainfores ,Biology (General) ,QH301-705.5 - Published
- 2020
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35. Abstract B04: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms
- Author
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Jong Woo Lee, Hee Sun Park, Sin-aye Park, Roy S. Herbst, and Jaseok Peter Koo
- Subjects
Cancer Research ,Oncology - Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR03) of the Conference Proceedings. Citation Format: Jong Woo Lee, Hee Sun Park, Sin-aye Park, Roy S. Herbst, Jaseok Peter Koo. Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr B04.
- Published
- 2014
36. Crevasse initiation and history within the McMurdo Shear Zone, Antarctica
- Author
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Lynn Kaluzienski, Peter Koons, Ellyn Enderlin, Gordon Hamilton, Zoe Courville, and Steven Arcone
- Subjects
Crevasses ,ice shelves ,ground-penetrating radar ,ice velocity ,Environmental sciences ,GE1-350 ,Meteorology. Climatology ,QC851-999 - Abstract
While large-scale observations of intensified fracture and rifting can be observed through remote-sensing observations, understanding crevasse initiation may best be achieved with small-scale observations in which crevasses can be directly observed. Here we investigate the kinematic drivers of crevasse initiation in the McMurdo Shear Zone (MSZ), Antarctica. We delineated 420 crevasses from ~95 km of 400 MHz frequency ground-penetrating radar data and compared these data with kinematic outputs derived from remotely-sensed ice surface velocities to develop a statistical method to estimate crevasse initiation threshold strain rate values. We found the MSZ to be dominated by simple shear and that surface shear strain rates proved best for predicting crevasse features, with regions of higher shear strain rate more likely to have a greater number of crevasses. In the surveyed portion of our study region, values of shear strain rate and vorticity rate derived from the MEaSUREs2 velocity dataset range between 0.005–0.020 and 0.006–0.022 a−1, respectively, with crevasses located at ≥0.011 and ≥0.013 a−1. While threshold values from this study cannot be directly applied to other glacial environments, the method described here should allow for the study of shear margin evolution and assessment of localized damage and weakening processes in other locations where in situ data are available.
- Published
- 2019
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37. Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring
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Yan Dong, Haimei Li, Liang Zhao, Peter Koopman, Feng Zhang, and Johnny X. Huang
- Subjects
crispr-cas9 ,off-target ,whole-genome sequencing ,genome editing ,Genetics ,QH426-470 - Abstract
The emergence of the CRISPR-Cas9 system has triggered a technical revolution in mammalian genome editing. Compared to traditional gene-targeting strategies, CRISPR-Cas9 technology offers a more efficient and cost-effective approach for generating genetically modified animal models. However, off-target cleavage in CRISPR-mediated genome editing is a major concern in the analysis of phenotypes as well as the selection of therapeutic targets. Here, we analyzed whole-genome sequencing (WGS) data from two knock-out (KO) mouse strains generated by using the CRISPR-Cas9 system targeting the Mmd and Paqr8 loci. A total of nine individuals were sequenced including two parents, four F1 offspring and three uninjected control mice. Using GATK and bcftools software, we identified two off-target events in the founder mice. The two CRISPR-Cas9-induced off-target events were predictable using Cas-OFFinder and were not passed on to the offspring that we investigated. In addition, our results indicated that the number of CRISPR-Cas9-induced mutations was not statistically distinguishable from the background de novo mutations (DNMs).
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- 2019
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38. Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop
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Ruben D. de Ruiter, Bernard J. Smilde, Gerard Pals, Nathalie Bravenboer, Petra Knaus, Ton Schoenmaker, Esmée Botman, Gonzalo Sánchez-Duffhues, Maurizio Pacifici, Robert J. Pignolo, Eileen M. Shore, Marjolein van Egmond, Hans Van Oosterwyck, Frederick S. Kaplan, Edward C. Hsiao, Paul B. Yu, Renata Bocciardi, Carmen Laura De Cunto, Patricia Longo Ribeiro Delai, Teun J. de Vries, Susanne Hilderbrandt, Richard T. Jaspers, Richard Keen, Peter Koolwijk, Rolf Morhart, Jan C. Netelenbos, Thomas Rustemeyer, Christiaan Scott, Clemens Stockklausner, Peter ten Dijke, James Triffit, Francesc Ventura, Roberto Ravazzolo, Dimitra Micha, and Elisabeth M. W. Eekhoff
- Subjects
fibrodysplasia ossificans progessiva (FOP) ,trials ,therapy ,disease models ,inflammation ,angiogenesis ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare progressive genetic disease effecting one in a million individuals. During their life, patients with FOP progressively develop bone in the soft tissues resulting in increasing immobility and early death. A mutation in the ACVR1 gene was identified as the causative mutation of FOP in 2006. After this, the pathophysiology of FOP has been further elucidated through the efforts of research groups worldwide. In 2015, a workshop was held to gather these groups and discuss the new challenges in FOP research. Here we present an overview and update on these topics.
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- 2021
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39. Abstract 2878: Targeting the CXCL5-CXCR2-CREB signaling axis suppresses growth, survival, and invasion of lung adenocarcinoma
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Jong Woo Lee, Jonathan M. Kurie, Hee Sun Park, Pierre Saintigny, Jaseok Peter Koo, and Roy S. Herbst
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Cancer Research ,Cell signaling ,Tumor microenvironment ,business.industry ,Cancer ,Tumor initiation ,respiratory system ,medicine.disease ,medicine.disease_cause ,respiratory tract diseases ,Oncology ,CXCL5 ,Immunology ,medicine ,Cancer research ,Adenocarcinoma ,Lung cancer ,business ,Carcinogenesis - Abstract
The role of chemokines and chemokine receptors has been evolving in cancer. Besides their functions in the immune system, they also play a critical role in tumor initiation, promotion and progression. Since the tumor microenvironment play a critical role in cancer development and progression, the immune components of the tumor microenvironment have gained attention in the recent decades for its critical role in tumorigenesis and tumor control. Recent studies have clearly demonstrated the importance of CXCR2 in the development of lung cancer. Our recent studies showed that CXCR2 expression in tumor cells was associated with poor prognosis in non-small cell lung cancer (NSCLC) patients (n=262). Analysis of gene expression profiles from the National Cancer Institute (NCI) Director's Challenge Cohort of in lung adenocarcinoma patients (n=442) revealed that overexpression of CXCR2 ligands and CXCR2 genes was clustered together in approximately 25% of lung adenocarcinoma patients. Expression of CXCR2 and its associated ligand gene cluster in tumor cells was associated with poor prognosis, smoking status, and poor histologic differentiation. Furthermore, CXCL5 was involved as an potent angiogenic factor in NSCLC. The objective of the current study was to establish the role of the CXCL5/CXCR2 axis in tumor growth and invasion and to determine its related molecular mechanisms. In the study, CXCL5 activated the CREB transcription factor via the pERK1/2-p90Rsk-pCREB signaling pathway. In addition, inhibitors of CXCR2 and downstream signal transduction molecules blocked the activation of pERK1/2-pRsk-pCREB signaling molecules. Blockade of the CXCR2 receptor, CXCR2-dependent signal molecules, or CREB resulted in suppression of NSCLC cell growth, survival and invasion. These results suggest that the CXCL5-CXCR2-CREB signaling axis may be a source of potential therapeutic targets in lung adenocarcinoma. . Citation Format: Hee Sun Park, Jong Woo Lee, Pierre Saintigny, Jonathan M. Kurie, Roy S. Herbst, Jaseok Peter Koo. Targeting the CXCL5-CXCR2-CREB signaling axis suppresses growth, survival, and invasion of lung adenocarcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2878. doi:10.1158/1538-7445.AM2013-2878
- Published
- 2013
40. Abstract 4382: Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer
- Author
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David F. Stern, Jaseok Peter Koo, Sin-Aye Park, James T. Platt, Roy S. Herbst, Hee Sun Park, and Jong Woo Lee
- Subjects
Cancer Research ,biology ,Response element ,Naphthol AS ,CREB ,Molecular biology ,ATF/CREB ,Oncology ,Gene expression ,Cancer research ,biology.protein ,CREB-binding protein ,Gene ,Transcription factor - Abstract
Cyclic-AMP response element-binding protein (CREB)-cAMP response element (CRE) transcriptional pathway plays a critical role in the growth and survival of non-small cell lung cancer (NSCLC) cells. Recruitment of CREB binding protein (CBP) is essential for the transcriptional activity of CREB. However, there is no specific drug in use blocking CREB-CRE transcriptional pathway which may become a new therapeutic target in anti-cancer strategy. Naphthol AS-E phosphate (NASEp) was identified as an inhibitor of CREB transcriptional activity by binding to the KIX domain of CBP and blocking its access to the KID domain in CREB. Our objective was to identify which genes and molecular pathways could be affected by NASEp that may alter target molecules through the regulation of a subset of CRE-containing genes. The effects of the CREB inhibitor NASEp on A549 lung carcinoma cells were examined on an Affymetrix HuGene 1.0 expression microarray and a list of significantly differentially regulated genes was generated. Gene Set Enrichment Analysis (GSEA) shows down-regulation of multiple cancer-related pathways including proliferation, RAS signaling, drug resistance and metastasis. Most significantly, a strong negative correlation with Rosty Cervical Cancer Proliferation Cluster, shows that NASEp inhibits the same set of genes which are up regulated by the E6 and E7 viral oncogenes. These viral elements are known to interact with CBP, which is the direct target of NASEp. Since CBP is known to be a cofactor to multiple transcription factors, we performed an additional round of GSEA using the motif-based Transcription Factor Targets gene set collection and represented the results using a Cytoscape network diagram to illustrate the multifactorial effects of NASEp. Particularly, we focused that several transcription factors regulating cell cycle-related genes. This study implicates potential combinational blockage of CREB and cell cycle-regulated proteins as a cancer therapy. Citation Format: Sin-Aye Park, James Platt, Hee Sun Park, Jong Woo Lee, David F. Stern, Roy S. Herbst, Jaseok Peter Koo. Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4382. doi:10.1158/1538-7445.AM2013-4382
- Published
- 2013
41. Abstract 3414: Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells
- Author
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Daniel Morgensztern, Julie Boyer, Jaseok Peter Koo, Roy S. Herbst, Hee Sun Park, Jong Woo Lee, Patricia E. Koch, and Seung-Hee Ryu
- Subjects
Cancer Research ,Cell growth ,Cyclin D ,Cyclin B ,Biology ,Cell biology ,Cyclin E2 ,Cyclin D1 ,Oncology ,Cancer research ,biology.protein ,CREB-binding protein ,Cyclin B1 ,Cyclin A2 - Abstract
The cyclic-AMP response element-binding protein (CREB) plays a critical role in the growth and survival of cancer cells as well as cell metabolism. Our previous studies have shown that enhanced CREB activity correlates with increased growth and survival of non-small cell lung cancer (NSCLC) cell lines. In addition, 2-naphthol AS-E phosphate (NASEp), a small molecule inhibitor of CREB, restricted growth of NSCLC cell lines which was associated with reduced expression of pro-angiogenic factors. NASEp distrupts binding of CREB binding protein (CREBBP) to CREB, however, the mechanism which CREB inhibition by NASEp regulates NSCLC cell growth and survival is not fully understood. Here, we found that NASEp inhibited cell growth, survival, anchorage-independent cell growth and invasion, and also completely blocked the expression of Ki-67 and PCNA, markers of cell proliferation in NSCLC cells. Mechanistically, NASEp caused cell cycle arrest at the sub-G1 or G2 phase through down-regulation of several cyclins (cyclin A2, cyclin B1, cyclin D1 and cyclin E2) and led to apoptosis in NSCLC-derived cell lines. Suppression of cyclin D1 was closely related to decreased expression of activator protein-1 (AP-1). Furthermore, in a murine xenograft model, NASEp significantly reduced tumor burden not only by down-regulating of cyclin E2 and PCNA, but also by induction of apoptosis. Taken together, these results suggest that inhibition of CREB activity through dissociation of CREB-CREBBP by NASEp may be a potent new therapeutic in NSCLC. Citation Format: Jong Woo Lee, Hee Sun Park, Seung-Hee Ryu, Patricia Koch, Julie Boyer, Daniel Morgensztern, Roy S. Herbst, Jaseok Peter Koo. Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3414. doi:10.1158/1538-7445.AM2013-3414
- Published
- 2013
42. Gene editing of the multi-copy H2A.B gene and its importance for fertility
- Author
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Nur Diana Anuar, Sebastian Kurscheid, Matt Field, Lei Zhang, Edward Rebar, Philip Gregory, Thierry Buchou, Josephine Bowles, Peter Koopman, David J. Tremethick, and Tatiana A. Soboleva
- Subjects
Chromatin ,Histone variants ,H2A.B ,RNA polymerase II ,Pre-mRNA splicing ,Splicing speckles ,Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In the mouse, it is encoded by three different genes. H2A.B expression is spatially and temporally regulated during spermatogenesis being most highly expressed in the haploid round spermatid stage. Active genes gain H2A.B where it directly interacts with polymerase II and RNA processing factors within splicing speckles. However, the importance of H2A.B for gene expression and fertility are unknown. Results Here, we report the first mouse knockout of this histone variant and its effects on fertility, nuclear organization, and gene expression. In view of the controversy related to the generation of off-target mutations by gene editing approaches, we test the specificity of TALENs by disrupting the H2A.B multi-copy gene family using only one pair of TALENs. We show that TALENs do display a high level of specificity since no off-target mutations are detected by bioinformatics analyses of exome sequences obtained from three consecutive generations of knockout mice and by Sanger DNA sequencing. Male H2A.B.3 knockout mice are subfertile and display an increase in the proportion of abnormal sperm and clogged seminiferous tubules. Significantly, a loss of proper RNA Pol II targeting to distinct transcription–splicing territories and changes to pre-mRNA splicing are observed. Conclusion We have produced the first H2A.B knockout mouse using the TALEN approach.
- Published
- 2019
- Full Text
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43. Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9
- Author
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Brittany Croft, Thomas Ohnesorg, Jacqueline Hewitt, Josephine Bowles, Alexander Quinn, Jacqueline Tan, Vincent Corbin, Emanuele Pelosi, Jocelyn van den Bergen, Rajini Sreenivasan, Ingrid Knarston, Gorjana Robevska, Dung Chi Vu, John Hutson, Vincent Harley, Katie Ayers, Peter Koopman, and Andrew Sinclair
- Subjects
Science - Abstract
SRY and its target SOX9 are known key determinants in testis development. Here the authors by studying duplications and deletions upstream of SOX9 from patient samples with disorders of sex development (DSD) reveal enhancers for SOX9 critical for human sex development and DSD.
- Published
- 2018
- Full Text
- View/download PDF
44. Letter regarding 'ACVIM consensus statement on pancreatitis in cats'
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Peter Kook and Samuel Oppliger
- Subjects
Veterinary medicine ,SF600-1100 - Published
- 2021
- Full Text
- View/download PDF
45. The above letter was referred to the authors of the original paper and their reply follows
- Author
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Perry G. Fine, Peter Koo, and Bruce A. Ferrell
- Subjects
Psychoanalysis ,business.industry ,Medicine ,Geriatrics and Gerontology ,business - Published
- 2003
46. Collaboration Around Rare Bone Diseases Leads to the Unique Organizational Incentive of the Amsterdam Bone Center
- Author
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Elisabeth M. W. Eekhoff, Dimitra Micha, Tymour Forouzanfar, Teun J. de Vries, J. Coen Netelenbos, Jenneke Klein-Nulend, Jack J. W. A. van Loon, Wouter D. Lubbers, Lothar Schwarte, Patrick Schober, Pieter G. H. M. Raijmakers, Bernd P. Teunissen, Pim de Graaf, Adriaan A. Lammertsma, Maqsood M. Yaqub, Esmée Botman, Sanne Treurniet, Bernard J. Smilde, Arend Bökenkamp, Anco Boonstra, Otto Kamp, Jakko A. Nieuwenhuijzen, Marieke C. Visser, Hans J. C. Baayen, Max Dahele, Guus A. M. Eeckhout, Thadé P. M. Goderie, Cas Smits, Marjolijn Gilijamse, K. Hakki Karagozoglu, Paul van de Valk, Chris Dickhoff, Annette C. Moll, Frank F. D. Verbraak, Katie K. R. Curro-Tafili, Ebba A. E. Ghyczy, Thomas Rustemeyer, Peeroz Saeed, Alessandra Maugeri, Gerard Pals, Angela Ridwan-Pramana, Esther Pekel, Ton Schoenmaker, Willem Lems, Henri A. H. Winters, Matthijs Botman, Georgios F. Giannakópoulos, Peter Koolwijk, Jeroen J. W. M. Janssen, Peter Kloen, Nathalie Bravenboer, Jan Maerten Smit, and Marco N. Helder
- Subjects
rare bone diseases ,amsterdam bone center (ABC) ,collaborative organization ,non-hierarchical ,research ,clinical ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
In the field of rare bone diseases in particular, a broad care team of specialists embedded in multidisciplinary clinical and research environment is essential to generate new therapeutic solutions and approaches to care. Collaboration among clinical and research departments within a University Medical Center is often difficult to establish, and may be hindered by competition and non-equivalent cooperation inherent in a hierarchical structure. Here we describe the “collaborative organizational model” of the Amsterdam Bone Center (ABC), which emerged from and benefited the rare bone disease team. This team is often confronted with pathologically complex and under-investigated diseases. We describe the benefits of this model that still guarantees the autonomy of each team member, but combines and focuses our collective expertise on a clear shared goal, enabling us to capture synergistic and innovative opportunities for the patient, while avoiding self-interest and possible harmful competition.
- Published
- 2020
- Full Text
- View/download PDF
47. Re-Printing Architectural Heritage
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Juliette Bekkering, Barbara Kuit, Carola Hein, Michela Turrin, Joris Dik, John Hanna, Miktha Alkadri, Serdar Asut, Ulrich Knaack, Peter Koorstra, Albert Reinstra, Angela Dellebeke, Dave Vanhove, Dick Vlasblom, Jur Bekooy, Ron Teeuw, Valentin Vanhecke, and Wim Oostveen
- Subjects
3D printing ,3D scanning ,heritage ,architecture ,Architecture ,NA1-9428 - Abstract
Additive Manufacturing (commonly known as 3D printing) technology has become a global phenomenon. In the domain of heritage, 3D printing is seen as a time and cost efficient method for restoring vulnerable architectural structures. The technology can also provide an opportunity to reproduce missing or destroyed cultural heritage, in the cases of conflicts or environmental threats. This project takes the Hippolytuskerk in the Dutch village of Middelstum, as a case study to explore the limits of the existing technology, and the challenges of 3D printing of cultural heritage. Architectural historians, modelling experts, and industrial scientists from the universities of Delft and Eindhoven have engaged with diverse aspects of 3D printing, to reproduce a selected part of the 15th century church. This experimental project has tested available technologies to reproduce a mural on a section of one of the church’s vault with maximum possible fidelity to material, colors and local microstructures. The project shows challenges and opportunities of today’s technology for 3D printing in heritage, varying from the incapability of the scanning technology to capture the existing cracks in the required resolution, to the high costs of speciality printing, and the limited possibilities for combining both printing techniques for such a complex structure.
- Published
- 2019
- Full Text
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48. Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B
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Pavol Lopatka, Michal Gavenda, Martin Markovič, Peter Koóš, and Tibor Gracza
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Jaspine B ,flow chemistry ,palladium catalysis ,cyclisation ,carbonylation ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved the pBQ/LiCl as a reoxidation system and Fe(CO)5 as an in situ source of stoichiometric amount of carbon monoxide (1.5 molar equivalent). In addition, we have demonstrated the use of a flow reactor adopting proposed conditions in the large-scale preparation of key lactones.
- Published
- 2021
- Full Text
- View/download PDF
49. ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
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Josephine Bowles, Chun-Wei Feng, Kim Miles, Jessica Ineson, Cassy Spiller, and Peter Koopman
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Science - Abstract
Recent findings have challenged the established concept that retinoic acid (RA) induces foetal germ cells to enter meiosis. Here, Bowles et al. identify the enzyme ALDH1A1 as a source of ovarian RA that may induce meiosis even when other RA-synthetic enzymes are deleted.
- Published
- 2016
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- View/download PDF
50. Correction: Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.
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Nitzan Gonen, Alexander Quinn, Helen C O'Neill, Peter Koopman, and Robin Lovell-Badge
- Subjects
Genetics ,QH426-470 - Abstract
[This corrects the article DOI: 10.1371/journal.pgen.1006520.].
- Published
- 2017
- Full Text
- View/download PDF
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