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13 results on '"Peter Sawicki"'

1. The evolving value assessment of cancer therapies: Results from a modified Delphi study

Author

Myrto Lee, Hugo Larose, Martin Gräbeldinger, Jon Williams, Anne-Marie Baird, Susan Brown, Johannes Bruns, Russell Clark, Javier Cortes, Giuseppe Curigliano, Andrea Ferris, Louis P. Garrison, Y.K. Gupta, Ravindran Kanesvaran, Gary Lyman, Luca Pani, Zack Pemberton-Whiteley, Tomas Salmonson, Peter Sawicki, Barry Stein, Dong-Churl Suh, Galina Velikova, and Jens Grueger

Subjects
Public aspects of medicine, RA1-1270
Abstract

The move toward early detection and treatment of cancer presents challenges for value assessment using traditional endpoints. Current cancer management rarely considers the full economic and societal benefits of therapies. Our study used a modified Delphi process to develop principles for defining and assessing value of cancer therapies that aligns with the current trajectory of oncology research and reflects broader notions of value. 24 experts participated in consensus-building activities across 5 months (16 took part in structured interactions, including a survey, plenary sessions, interviews, and off-line discussions, while 8 participated in interviews). Discussion focused on: 1) which oncology-relevant endpoints should be used for assessing treatments for early-stage cancer and access decisions for early-stage treatments, and 2) the importance of additional value components and how these can be integrated in value assessments. The expert group reached consensus on 4 principles in relation to the first area (consider oncology-relevant endpoints other than overall survival; build evidence for endpoints that provide earlier indication of efficacy; develop evidence for the next generation of predictive measures; use managed entry agreements supported by ongoing evidence collection to address decision-maker evidence needs) and 3 principles in relation to the second (routinely use patient reported outcomes in value assessments; assess broad economic impact of new medicines; consider other value aspects of relevance to patients and society).

Published
2024
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2. Cancer Therapy Based on a Mechanism of Action for Controlling the Immune System and the Resulting Patent Portfolio

Author

Z. Peter Sawicki and Visala C. Goswitz

Subjects
Mechanism (biology), business.industry, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Cancer therapy, Cancer, General Medicine, Disease, medicine.disease, surgical procedures, operative, Immune system, Patent portfolio, Mechanism of action, Drug Discovery, Immunology, medicine, Cancer research, Immunology and Allergy, Patent prosecution, medicine.symptom, business
Abstract

Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease. Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemo- therapy or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host disease (GVHD). The mechanism described here relates to generating the Mirror Effect™ that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft (HVG) response. The HVT effect generated by inducing the Mirror Effect™ in a host is effective in cancer therapy, as well as other diseases. The patent strategy, employed for successful patent prosecution related to the elucidation of the Mirror Effect™, is also dis- cussed.

Published
2012
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3. Mahatma Gandhi : Ein indischer Patriot

Author

Peter Sawicki and Peter Sawicki

Abstract

Mahatma Gandhi: Er sei, so Martin Luther King, der erste Mensch der Neuzeit gewesen, der die Lehren Jesu vollends verinnerlicht und sie als politisches Mittel genutzt habe. Dies ist nur eine der Huldigungen, die Mahatma Gandhi seit dessen Ermordung 1948 zuteil geworden sind. Für Millionen Menschen weltweit ist Gandhi seitdem stets ein Vorbild gewesen, ein Sinnbild für Frieden und eine Ikone des gewaltlosen Widerstands. Zu Recht? Diese Frage ist in den bisherigen Lebensbeschreibungen des Inders selten gestellt worden. Denn es gab auch eine andere Seite des politischen Anführers der indischen Freiheitsbewegung: die des sturen Machtpolitikers, dessen Toleranz Grenzen aufwies. Und auch die des rigorosen Gurus, der die Mitbewohner in seiner Aschram-Gemeinde auf ein hartes, asketisches Leben trimmte. Diese Kurzbiographie zeichnet ein modernes Bild des Menschen Mahatma Gandhi. Die Reihe'Geschichte kompakt'bietet einen zeitgemäßen Zugriff auf Themen und Fragen der Weltgeschichte - geeignet für Schule und (Eigen-)Studium, zum Nachlesen, Nachschlagen, Lernen, auf den aktuellen Stand bringen und Bescheidwissen. Mit historischen Fotografien. Zum Autor: Peter Sawicki studierte Geschichte, Politologie und Kommunikationswissenschaften an der Rheinischen Friedrich-Wilhelms-Universität Bonn und National University of Singapore (Auslandssemester); Master an der Humboldt-Universität zu Berlin; freier Autor und Journalist.

Published
2012

4. Cancer therapy based on a mechanism of action for controlling the immune system and the resulting patent portfolio

Author

Visala C, Goswitz and Z Peter, Sawicki

Subjects
Patents as Topic, Neoplasms, Graft vs Tumor Effect, Animals, Graft vs Host Disease, Humans, Transplantation, Homologous, Immunotherapy, Bone Marrow Transplantation
Abstract

Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease. Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemotherapy or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host disease (GVHD). The mechanism described here relates to generating the Mirror Effect™ that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft (HVG) response. The HVT effect generated by inducing the Mirror Effect™ in a host is effective in cancer therapy, as well as other diseases. The patent strategy, employed for successful patent prosecution related to the elucidation of the Mirror Effect™, is also discussed.

Published
2012

6. Institute for Quality and Efficiency in Health Care: Germany

Author

Mona, Nasser and Peter, Sawicki

Subjects
Clinical Trials as Topic, Internet, Evidence-Based Medicine, Insurance, Health, Technology Assessment, Biomedical, Quality Assurance, Health Care, Cost-Benefit Analysis, Health Policy, Advisory Committees, Community Participation, Community-Institutional Relations, Insurance Coverage, State Medicine, Decision Support Techniques, Access to Information, Germany, Insurance, Health, Reimbursement, Humans
Abstract

The Institute for Quality and Efficiency in Health Care (IQWiG) was established in 2004 to provide Germany's Federal Joint Committee with evidence-based evaluations of the benefits and cost benefits of health services, and functions in an advisory role. IQWiG reviews available evidence and produces recommendations after an extensive process of consultation with experts and stakeholders. IQWiG's recommendations are then considered by the Joint Committee in issuing coverage and payment directives. Under German law, insurance funds must cover any service that is medically necessary, which means that cost-effectiveness analysis can only be used to exclude a treatment from coverage if at least one equivalent alternative exists.

Published
2009

8. Institute for Quality and Efficiency in Health Care: Germany

Author

Mona Nasser, Mona Nasser, Peter Sawicki, Mona Nasser, Mona Nasser, and Peter Sawicki

Abstract

Provides an overview of evidence-based policy making in the German healthcare system. Focuses on the Institute for Quality and Efficiency in Health Care, which evaluates comparative effectiveness of drugs and medical services for decisions on coverage.

Published
2009

11. Evaluation einer abteilungsinternen Leitlinie zur Diagnostik der tiefen Beinvenenthrombose.

Author

Rainer Puschmann, Heinrich Franz, and Peter Sawicki

Abstract

Copyright of Medizinische Klinik (Urban & Vogel) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007

13. Quality of Health Care in Germany. A Six-Country Comparison.

Author

Peter Sawicki

Abstract

Sicker adults in Germany suffer many of the same issues and concerns as do sicker adults in Australia, Canada, New Zealand, the United Kingdom, and the USA. However, quality of care in sicker adults in Germany stands out from the other countries in a few key areas: [ABSTRACT FROM AUTHOR]

Published
2005

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