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3. Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery

Author

Quinten, C., Kenis, C., Decoster, L., Debruyne, P. R., De Groof, I., Focan, C., Cornelis, F., Verschaeve, V., Bachmann, C., Bron, D., Luce, S., Debugne, G., Van den Bulck, H., Goeminne, J. C., Baitar, A., Geboers, K., Petit, B., Langenaeken, C., Van Rijswijk, R., Specenier, P., Jerusalem, G., Praet, J. P., Vandenborre, K., Lycke, M., Flamaing, J., Milisen, K., Lobelle, J. P., and Wildiers, H.

Published
2019

5. End-of-life healthcare utilization in older patients with cancer: a large Belgian data linkage study

Author

Depoorter, V., primary, Vanschoenbeek, K., additional, Decoster, L., additional, Silversmit, G., additional, Debruyne, P., additional, De Groof, I., additional, Bron, D., additional, Cornélis, F., additional, Luce, S., additional, Focan, C., additional, Verschaeve, V., additional, Debugne, G., additional, Langenaeken, C., additional, Van Den Bulck, H., additional, Goeminne, J.C., additional, Teurfs, W., additional, Jerusalem, G., additional, Schrijvers, D., additional, Petit, B., additional, Rasschaert, M., additional, Praet, J.P., additional, Vandenborre, K., additional, De Schutter, H., additional, Milisen, K., additional, Flamaing, J., additional, Kenis, C., additional, Verdoodt, F., additional, and Wildiers, H., additional

Published
2023
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6. Palliative care at the end-of-life in older patients with cancer and associated age-related factors

Author

Depoorter, V., primary, Vanschoenbeek, K., additional, Decoster, L., additional, Silversmit, G., additional, Debruyne, P., additional, De Groof, I., additional, Bron, D., additional, Cornélis, F., additional, Luce, S., additional, Focan, C., additional, Verschaeve, V., additional, Debugne, G., additional, Langenaeken, C., additional, Van Den Bulck, H., additional, Goeminne, J.C., additional, Teurfs, W., additional, Jerusalem, G., additional, Schrijvers, D., additional, Petit, B., additional, Rasschaert, M., additional, Praet, J.P., additional, Vandenborre, K., additional, De Schutter, H., additional, Milisen, K., additional, Flamaing, J., additional, Kenis, C., additional, Verdoodt, F., additional, and Wildiers, H., additional

Published
2023
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7. Dosimetric and biologic intercomparison between electron and proton FLASH beams

Author

Almeida, A, primary, Togno, M, additional, Ballesteros-Zebadua, P, additional, Franco-Perez, J, additional, Geyer, R, additional, Schaefer, R, additional, Petit, B, additional, Grilj, V, additional, Meer, D, additional, Safai, S, additional, Lomax, T, additional, Weber, DC, additional, Bailat, C, additional, Psoroulas, S, additional, and Vozenin, MC, additional

Published
2023
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8. Adherence to geriatric assessment-based recommendations in older patients with cancer: a multicenter prospective cohort study in Belgium

Author

Kenis, C., Decoster, L., Flamaing, J., Debruyne, P.R., De Groof, I., Focan, C., Cornélis, F., Verschaeve, V., Bachmann, C., Bron, D., Luce, S., Debugne, G., Van den Bulck, H., Goeminne, J.-C., Schrijvers, D., Geboers, K., Petit, B., Langenaeken, C., Van Rijswijk, R., Specenier, P., Jerusalem, G., Praet, J.-P., Vandenborre, K., Lobelle, J.-P., Lycke, M., Milisen, K., and Wildiers, H.

Published
2018
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9. Marker-assisted breeding (MAB) on apple and pear and new approaches for QTLs and major gene genotyping involved in disease resistance

Author

Petiteau, A., Denancé, Caroline, Muranty, Hélène, Durel, Charles-Eric, García-Gómez, Beatriz E., Aranzana, Maria José, Lebreton, F., Guérif, P., Cournol, M., Petit, B., Guyader, A., Laurens, François, Petiteau, A., Denancé, Caroline, Muranty, Hélène, Durel, Charles-Eric, García-Gómez, Beatriz E., Aranzana, Maria José, Lebreton, F., Guérif, P., Cournol, M., Petit, B., Guyader, A., and Laurens, François

Abstract

Apple and pear breeding is a long process that can take more than 20 years. Considering the future challenges of fruit tree growing in a climate change scenario (high fruit quality and regular production), improving breeding program efficiency is essential. A good strategy to increase breeding program efficiency is the development of SNP-type molecular markers and their application in marker-assisted breeding (MAB). Several tools such as the Illumina 20K chip and the Affymetrix-Axiom 480K (apple-fruit) and 70K (pear) chips have been developed to map SNP markers on the respective genomes. However, the practical use of molecular markers by breeders is still disconnected from academic knowledge. To overcome this gap, we selected several SNP-type molecular markers in apple and pear, and assayed and validated them in apple and pear breeding programs. After an evaluation of their benefits and limitations, they were applied in the progenitor and elite genotype selections to increase the efficiency of the breeding process. To do so, published SNP-type molecular markers associated with major genes in apple and developed new markers linked to QTLs involved in disease resistance in pear were assayed and validated. This set of validated molecular markers is now routinely applied as MAB in our breeding programs. In this paper, we present two different methodologies for searching and validating SNP-type molecular markers, discuss the uses and limitations of these markers within apple and pear breeding programs and propose some strategies to improve their breeding efficiency.

Published
2023

10. End-of-Life Care in the Last Three Months before Death in Older Patients with Cancer in Belgium: A Large Retrospective Cohort Study Using Data Linkage

Author

Depoorter, Victoria, Vanschoenbeek, Katrijn, Decoster, Lore, Silversmit, Geert, Debruyne, Philip P.R., De Groof, I., Bron, Dominique, Cornélis, Frank, Luce, Sylvie, Focan, Christian, Verschaeve, Vincent, Debugne, G., Langenaeken, Christine, Van Den Bulck, Heidi, Goeminne, Jean Charles, Teurfs, Wesley, Jerusalem, Guy, Schrijvers, Dirk, Petit, B., Rasschaert, Marika, Praet, Jean Philippe, Vandenborre, Katherine, De Schutter, Harlinde, Milisen, Koen, Flamaing, Johan, Kenis, Cindy, Verdoodt, Freija, Wildiers, Hans, Depoorter, Victoria, Vanschoenbeek, Katrijn, Decoster, Lore, Silversmit, Geert, Debruyne, Philip P.R., De Groof, I., Bron, Dominique, Cornélis, Frank, Luce, Sylvie, Focan, Christian, Verschaeve, Vincent, Debugne, G., Langenaeken, Christine, Van Den Bulck, Heidi, Goeminne, Jean Charles, Teurfs, Wesley, Jerusalem, Guy, Schrijvers, Dirk, Petit, B., Rasschaert, Marika, Praet, Jean Philippe, Vandenborre, Katherine, De Schutter, Harlinde, Milisen, Koen, Flamaing, Johan, Kenis, Cindy, Verdoodt, Freija, and Wildiers, Hans

Abstract

This study aims to describe end-of-life (EOL) care in older patients with cancer and investigate the association between geriatric assessment (GA) results and specialized palliative care (SPC) use. Older patients with a new cancer diagnosis (2009–2015) originally included in a previous multicentric study were selected if they died before the end of follow-up (2019). At the time of cancer diagnosis, patients underwent geriatric screening with Geriatric 8 (G8) followed by GA in case of a G8 score ≤14/17. These data were linked to the cancer registry and healthcare reimbursement data for follow-up. EOL care was assessed in the last three months before death, and associations were analyzed using logistic regression. A total of 3546 deceased older patients with cancer with a median age of 79 years at diagnosis were included. Breast, colon, and lung cancer were the most common diagnoses. In the last three months of life, 76.3% were hospitalized, 49.1% had an emergency department visit, and 43.5% received SPC. In total, 55.0% died in the hospital (38.5% in a non-palliative care unit and 16.4% in a palliative care unit). In multivariable analyses, functional and cognitive impairment at cancer diagnosis was associated with less SPC. Further research on optimizing EOL healthcare utilization and broadening access to SPC is needed., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

11. A Belgian survey on geriatric assessment in oncology focusing on large-scale implementation and related barriers and facilitators

Author

Kenis, C., Heeren, P., Decoster, L., Van Puyvelde, K., Conings, G., Cornelis, F., Cornette, P., Moor, R., Luce, S., Libert, Y., Van Rijswijk, R., Jerusalem, G., Rasschaert, M., Langenaeken, C., Baitar, A., Specenier, P., Geboers, K., Vandenborre, K., Debruyne, P.R., Vanoverbeke, K., Van Den Bulck, H., Praet, J.-P., Focan, C., Verschaeve, V., Nols, N., Goeminne, J.-C., Petit, B., Lobelle, J.-P., Flamaing, J., Milisen, K., and Wildiers, Hans

Published
2016
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12. Maladie thromboembolique veineuse associée au cancer : combien de patients atteints de cancer du poumon vus en pratique clinique seraient éligibles à un essai contrôlé randomisé sur les AODs ?

Author

Petit, B., primary, Mismetti, V., additional, Soudet, S., additional, Poenou, G., additional, Zarrat, E., additional, Machuron, T., additional, Accassat, S., additional, Plaisance, L., additional, Helfer, H., additional, Le Hello, C., additional, Sevestre, M.A., additional, Mahé, I., additional, and Bertoletti, L., additional

Published
2023
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15. Hospitalizations, emergency department visits and home care in older patients after cancer diagnosis: results from a large data linkage study with 3 year follow-up

Author

Depoorter, V., primary, Vanschoenbeek, K., additional, Decoster, L., additional, De Schutter, H., additional, Debruyne, P.R., additional, De Groof, I., additional, Bron, D., additional, Cornélis, F., additional, Luce, S., additional, Focan, C., additional, Verschaeve, V., additional, Debugne, G., additional, Langenaeken, C., additional, Van Den Bulck, H., additional, Goeminne, J.C., additional, Teurfs, W., additional, Jerusalem, G., additional, Schrijvers, D., additional, Petit, B., additional, Rasschaert, M., additional, Praet, J.P., additional, Vandenborre, K., additional, Milisen, K., additional, Flamaing, J., additional, Kenis, C., additional, Verdoodt, F., additional, and Wildiers, H., additional

Published
2022
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16. Cancer Associated Thrombosis:how many lung cancer patients seen in clinical practice would be eligible to a DOAC randomized controlled trial?

Author

Petit, B, primary, Mismetti, V, additional, Soudet, S, additional, Poenou, G, additional, Zarrat, E, additional, Machuron, T, additional, Acassat, S, additional, Plaisance, L, additional, Helfer, H, additional, Le Hello, C, additional, Sevestre, M, additional, Mahé, I, additional, and Bertoletti, L, additional

Published
2022
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20. PO-41: Cancer-associated thrombosis: how many patients seen in clinical practice would be eligible to a randomized controlled trial?

Author

Petit, B., primary, Soudet, S., additional, Poenou, G., additional, Zarrat, E., additional, Machuron, T., additional, Accassat, S., additional, Plaisance, L., additional, Helfer, H., additional, Mismetti, V., additional, Le Hello, C., additional, Sevestre, M.-A., additional, Mahé, I., additional, and Bertoletti, L., additional

Published
2022
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23. FLASH in the Clinic Track (Oral Presentations) A RANDOMIZED CLINICAL PHASE-III-TRIAL COMPARING SINGLE-HIGH DOSE FLASH-RADIOTHERAPY VERSUS CONVENTIONALLY FRACTIONATED RADIOTHERAPY IN CAT-PATIENTS WITH SQUAMOUS CELL CARCINOMA: EARLY STOPPING DUE TO LATE TOXICITY

Author

Bley, C. Rohrer, primary, Wolf, F., additional, Goncalves, P. Jorge, additional, Petridis, I., additional, Petit, B., additional, Bourhis, J., additional, Meier, V., additional, and Vozenin, M.-C., additional

Published
2022
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25. IMPACT OF DOSE RATE DELIVERED WITH ELECTRON, PROTON AND PHOTON BEAMS ON THE DEVELOPMENT OF ZEBRAFISH EMBRYOS

Author

Ollivier, J., primary, Grilj, V., additional, Goncalves, P. Jorge, additional, Petit, B., additional, Martinotti, A., additional, Barrera, P., additional, Psoroulas, S., additional, Nesteruk, K., additional, Meer, D., additional, Togno, M., additional, Safai, S., additional, Folkerts, M., additional, Pfister, S., additional, Sharma, R., additional, Lomax, A.J., additional, Weber, D.C., additional, and Vozenin, M.-C., additional

Published
2022
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30. Geriatric screening and assessment among older patients with cancer: evaluation of long-term outcomes in a multicentric cohort of > 7, 000 patients

Author

Depoorter, V., primary, Vanschoenbeek, K., additional, Decoster, L., additional, De Schutter, H., additional, Debruyne, P.R., additional, De Groof, I., additional, Bron, D., additional, Cornélis, F., additional, Luce, S., additional, Focan, C., additional, Verschaeve, V., additional, Debugne, G., additional, Langenaeken, C., additional, Van Den Bulck, H., additional, Goeminne, J.C., additional, Teurfs, W., additional, Jerusalem, G., additional, Schrijvers, D., additional, Petit, B., additional, Geboers, K., additional, Forceville, K., additional, Praet, J.P., additional, Vandenborre, K., additional, Milisen, K., additional, Flamaing, J., additional, Kenis, C., additional, Verdoodt, F., additional, and Wildiers, H., additional

Published
2021
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33. Additional file 1 of Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies

Author

Straub, M., Sigman, D. M., Auderset, A., Ollivier, J., Petit, B., Hinnenberg, B., Rubach, F., Oleynik, S., Vozenin, M.-C., and Martínez-García, A.

Abstract

Additional file 1: Figure SI-1. Illustration of a tumor mass formed by H454 tumors (T) in the striatum of the neural and adjacent tissue (TB = tumor bed). The healthy, normal neural tissue (NT) was sampled in the contralateral region, which is tumor-free. Figure SI-2. The left panel shows an illustration of the tumor mass formed by MEERL95 tumors (T = tumor) in the submandibular region. It infiltrates the adjacent healthy subcutaneous and muscular tissues (S=skin, SG = salivary gland, M = muscle). The right panel shows a 20-fold higher magnification of the margin (m). Infiltration of tumor cells (purple) into the stromal tissue (pink) forms an irregular margin (m). Intravascular tumor cell aggregates and smaller clusters of tumor cells are also found further away from the primary tumor in the subcutaneous zone (*). For our study, margin and tumor were sampled. Table SI-1. Isotopic measurements performed on the cell samples. At the bottom of the table, average values for reference standards and procedural oxidation blank are shown. Table SI-2. Isotopic measurements performed in April 2019. The data includes the Head&Neck data from mice 1, 2 and 3 and the brain tumor data from mice 1, 2 and 3. At the bottom of the table, values for reference standards and procedural oxidation blank are shown. Table SI-3. Isotopic measurements performed in September 2019. The data include the Head&Neck data from mice 4 and 5. At the bottom of the table values for reference standards and procedural oxidation blank are shown. Table SI-4. Isotopic measurements performed in November 2019. The data includes the brain tumor data from mice 4, 5, 6 and 7. At the bottom of the table, values for reference standards and procedural oxidation blank are shown. Table SI-5. Results of USGS65 measurements across the range of N contents of our tissue samples. Our results show no statistically significant difference in δ15N, indicating full conversion of the organic N during the oxidation step.

Published
2021
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34. SIOG2023-5-P-386 - Palliative care at the end-of-life in older patients with cancer and associated age-related factors

Author

Depoorter, V., Vanschoenbeek, K., Decoster, L., Silversmit, G., Debruyne, P., De Groof, I., Bron, D., Cornélis, F., Luce, S., Focan, C., Verschaeve, V., Debugne, G., Langenaeken, C., Van Den Bulck, H., Goeminne, J.C., Teurfs, W., Jerusalem, G., Schrijvers, D., Petit, B., Rasschaert, M., Praet, J.P., Vandenborre, K., De Schutter, H., Milisen, K., Flamaing, J., Kenis, C., Verdoodt, F., and Wildiers, H.

Published
2023
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35. SIOG2023-5-P-342 - End-of-life healthcare utilization in older patients with cancer: a large Belgian data linkage study

Author

Depoorter, V., Vanschoenbeek, K., Decoster, L., Silversmit, G., Debruyne, P., De Groof, I., Bron, D., Cornélis, F., Luce, S., Focan, C., Verschaeve, V., Debugne, G., Langenaeken, C., Van Den Bulck, H., Goeminne, J.C., Teurfs, W., Jerusalem, G., Schrijvers, D., Petit, B., Rasschaert, M., Praet, J.P., Vandenborre, K., De Schutter, H., Milisen, K., Flamaing, J., Kenis, C., Verdoodt, F., and Wildiers, H.

Published
2023
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