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11 results on '"Petrasheuskaya, Tatsiana V."'

5. Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters

Author

Milunovic, Miljan N. M., primary, Ohui, Katerina, additional, Besleaga, Iuliana, additional, Petrasheuskaya, Tatsiana V., additional, Dömötör, Orsolya, additional, Enyedy, Éva A., additional, Darvasiova, Denisa, additional, Rapta, Peter, additional, Barbieriková, Zuzana, additional, Vegh, Daniel, additional, Tóth, Szilárd, additional, Tóth, Judit, additional, Kucsma, Nóra, additional, Szakács, Gergely, additional, Popović-Bijelić, Ana, additional, Zafar, Ayesha, additional, Reynisson, Jóhannes, additional, Shutalev, Anatoly D., additional, Bai, Ruoli, additional, Hamel, Ernest, additional, and Arion, Vladimir B., additional

Published
2024
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7. Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities

Author

Petrasheuskaya, Tatsiana V., primary, Kovács, Ferenc, additional, Igaz, Nóra, additional, Rónavári, Andrea, additional, Hajdu, Bálint, additional, Bereczki, Laura, additional, May, Nóra V., additional, Spengler, Gabriella, additional, Gyurcsik, Béla, additional, Kiricsi, Mónika, additional, Frank, Éva, additional, and Enyedy, Éva A., additional

Published
2022
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8. Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities.

Author

Petrasheuskaya, Tatsiana V., Kovács, Ferenc, Igaz, Nóra, Rónavári, Andrea, Hajdu, Bálint, Bereczki, Laura, May, Nóra V., Spengler, Gabriella, Gyurcsik, Béla, Kiricsi, Mónika, Frank, Éva, and Enyedy, Éva A.

Subjects
*ELECTROSPRAY ionization mass spectrometry, *ELECTRON paramagnetic resonance spectroscopy, *NUCLEAR magnetic resonance spectroscopy, *SEMICARBAZONES, *COPPER compounds, *STABILITY constants
Abstract

A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition

Author

Besleaga, Iuliana, primary, Stepanenko, Iryna, additional, Petrasheuskaya, Tatsiana V., additional, Darvasiova, Denisa, additional, Breza, Martin, additional, Hammerstad, Marta, additional, Marć, Małgorzata A., additional, Prado-Roller, Alexander, additional, Spengler, Gabriella, additional, Popović-Bijelić, Ana, additional, Enyedy, Eva A., additional, Rapta, Peter, additional, Shutalev, Anatoly D., additional, and Arion, Vladimir B., additional

Published
2021
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10. Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Author

Milunović, Miljan N. M., primary, Palamarciuc, Oleg, additional, Sirbu, Angela, additional, Shova, Sergiu, additional, Dumitrescu, Dan, additional, Dvoranová, Dana, additional, Rapta, Peter, additional, Petrasheuskaya, Tatsiana V., additional, Enyedy, Eva A., additional, Spengler, Gabriella, additional, Ilic, Marija, additional, Sitte, Harald H., additional, Lubec, Gert, additional, and Arion, Vladimir B., additional

Published
2020
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11. Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity

Author

Petrasheuskaya, Tatsiana V., primary, Kiss, Márton A., additional, Dömötör, Orsolya, additional, Holczbauer, Tamás, additional, May, Nóra V., additional, Spengler, Gabriella, additional, Kincses, Annamária, additional, Čipak Gašparović, Ana, additional, Frank, Éva, additional, and Enyedy, Éva A., additional

Published
2020
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