180 results on '"Petrović, Oleg"'
Search Results
2. Mercury speciation in prenatal exposure in Slovenian and Croatian population – PHIME study
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Trdin, Ajda, Snoj Tratnik, Janja, Mazej, Darja, Fajon, Vesna, Krsnik, Mladen, Osredkar, Joško, Prpić, Igor, Špirić, Zdravko, Petrović, Oleg, Marc, Janja, Neubauer, David, Kodrič, Jana, Kobal, Alfred B., Barbone, Fabio, Falnoga, Ingrid, and Horvat, Milena
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- 2019
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3. Prenatal mercury exposure and child neurodevelopment outcomes at 18 months: Results from the Mediterranean PHIME cohort
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Barbone, Fabio, Rosolen, Valentina, Mariuz, Marika, Parpinel, Maria, Casetta, Anica, Sammartano, Francesca, Ronfani, Luca, Vecchi Brumatti, Liza, Bin, Maura, Castriotta, Luigi, Valent, Francesca, Little, D'Anna Latesha, Mazej, Darja, Snoj Tratnik, Janja, Miklavčič Višnjevec, Ana, Sofianou, Katia, Špirić, Zdravko, Krsnik, Mladen, Osredkar, Joško, Neubauer, David, Kodrič, Jana, Stropnik, Staša, Prpić, Igor, Petrović, Oleg, Vlašić-Cicvarić, Inge, and Horvat, Milena
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- 2019
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4. Fetal nephrolithiasis: What do we know so far?
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Petrović, Oleg, primary, Flajšman Raspor, Sanja, additional, Krajina, Robert, additional, and Ivandić, Jelena, additional
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- 2023
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5. Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism
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Snoj Tratnik, Janja, Falnoga, Ingrid, Trdin, Ajda, Mazej, Darja, Fajon, Vesna, Miklavčič, Ana, Kobal, Alfred B., Osredkar, Joško, Sešek Briški, Alenka, Krsnik, Mladen, Neubauer, David, Kodrič, Jana, Stropnik, Staša, Gosar, David, Lešnik Musek, Petra, Marc, Janja, Jurkovič Mlakar, Simona, Petrović, Oleg, Vlašić-Cicvarić, Inge, Prpić, Igor, Milardović, Ana, Radić Nišević, Jelena, Vuković, Danijela, Fišić, Elizabeta, Špirić, Zdravko, and Horvat, Milena
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- 2017
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6. Fetal nephrolithiasis: What do we know so far?
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Petrović, Oleg, Flajšman Raspor, Sanja, Krajina, Robert, and Ivandić, Jelena
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KIDNEY stones , *URINARY organs - Abstract
Synopsis: Fetal nephrolithiasis is a rare, benign condition that seems to be predominantly unilateral, more common in males, and can be associated with urinary tract pathology. [ABSTRACT FROM AUTHOR]
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- 2024
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7. The influence of pre-eclampsia on fetal lung maturity
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Štimac, Tea, Petrović, Oleg, Krajina, Robert, and Finderle, Aleks
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- 2012
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8. Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism
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Tratnik, Janja Snoj, Falnoga, Ingrid, Trdin, Ajda, Mazej, Darja, Fajon, Vesna, Miklavčič, Ana, Kobal, Alfred B., Osredkar, Joško, Briški, Alenka Sešek, Krsnik, Mladen, Neubauer, David, Kodrič, Jana, Stropnik, Staša, Gosar, David, Musek, Petra Lešnik, Marc, Janja, Mlakar, Simona Jurkovič, Petrović, Oleg, Vlašić-Cicvarić, Inge, Prpić, Igor, Milardović, Ana, Nišević, Jelena Radić, Vuković, Danijela, Fišić, Elizabeta, Špirić, Zdravko, and Horvat, Milena
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- 2017
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9. Croatian society for perinatal medicine: Consensus statement and recommendations for the risk assessment of preeclampsia
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Đelmiš, Josip, Habek, Dubravko, Ivanišević, Marina, Košec, Vesnica, Muller, Andrijana, Petrović, Oleg, Roje, Damir, and Vulić, Marko
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- 2021
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10. How should we screen for gestational diabetes?
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Petrović, Oleg
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- 2014
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11. The Prevalence of Live Birth Down Syndrome in the Region of Primorsko-goranska County in Croatia, 1996–2005: The Impact of Screening and Amniocentesis
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Brajenović-Milić, Bojana, Prpić, Igor, Petrović, Oleg, Ristić, Smiljana, Brumini, Gordana, and Kapović, Miljenko
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- 2008
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12. Nutrient Intake during Pregnancy and Adherence to Dietary Recommendations: The Mediterranean PHIME Cohort
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Concina, Federica, primary, Pani, Paola, additional, Carletti, Claudia, additional, Rosolen, Valentina, additional, Knowles, Alessandra, additional, Parpinel, Maria, additional, Ronfani, Luca, additional, Mariuz, Marika, additional, Vecchi Brumatti, Liza, additional, Valent, Francesca, additional, Little, D’Anna, additional, Petrović, Oleg, additional, Prpić, Igor, additional, Špirić, Zdravko, additional, Sofianou-Katsoulis, Aikaterini, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Horvat, Milena, additional, and Barbone, Fabio, additional
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- 2021
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13. Bifid cardiac apex in Pallister-Killian syndrome
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Barišić, Anita, primary, Finderle, Aleks, additional, Petrović, Oleg, additional, and Vraneković, Jadranka, additional
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- 2020
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14. Spontaneous fetal skull fractures - an unsolved issue?
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Petrović, Oleg, Despot, Đuro, Bilić Čače, Iva, and Cuculić, Dražen
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vaginal birth ,obstetric providers ,Fetal skull fractures ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Vaginal birth ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,fetal skull fractures ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,fetus ,birth trauma ,obstetric trauma ,risk factors ,Fetus ,Risk factors ,Obstetric providers ,Birth trauma ,Obstetric trauma - Abstract
Spontaneous skull fractures are particularly interesting due to the vague circumstances of their occurrence. Apart from scientific and professional significance, fetal fractures may have medico-legal implications for obstetricians and midwives because their spontaneous occurrence in the majority of cases is exceedingly difficult to prove. The aim of the article is to investigate some new risk factors and mechanisms of spontaneous fetal skull fracture occurrence and to recommend measures for their prevention. Based on two case reports of spontaneous depressed fetal skull fractures under different circumstances authors have discussed potential new risk factors and relevant pathophysiological mechanisms of spontaneous skull fractures. An understanding of risk factors and the mechanism(s) contributing to spontaneous skull injuries, may provide medical professionals with significant knowledge in assisting both the prevention of new cases and in court proceedings. The purpose is to assist those obstetric practitioners accused of potential malpractice, in addition to medical experts involved in adjudicating any potential cases for malpractice. The authors anticipate that with new evidence and additional practical recommendations will initiate a broad professional discussion which might help many obstetric providers to pay attention to risk factors and mechanisms, so that potential fetal/neonatal skull fractures could be avoided. Additionally, the benefits for obstetric practitioners who are accused of potential malpractice and for medical experts who may adjudicate it, cannot be understated.
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- 2020
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15. Prenatal diagnosis of complete trisomy 19q
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Babić, Ivana, Brajenović-Milić, Bojana, Petrović, Oleg, Mustać, Elvira, and Kapović, Miljenko
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- 2007
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16. Bifid cardiac apex in Pallister Killian syndrome: case report
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Barišić, Anita, Finderle, Aleks, Petrović, Oleg, Starčević Čizmarević, Nada, Ostojić, Saša, and Vraneković, Jadranka
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bifid cardiac apex, chromosomal analyses, Pallister Killian syndrome, prenatal diagnosis, ultrasound examination - Abstract
Background: Pallister-Killian syndrome (PKS) is a sporadic, rare chromosomal disorder, caused by tissue-limited mosaicism for an isochromosome 12p (i12p). Prenatal diagnosis of PKS is generally incidental at karyotyping in case of fetal anomaly detection or advanced maternal age. Although clinical presentation of PKS varies, cytogenetic findings are constant, and include a tetrasomy of chromosome 12p diagnosed by chorionic villus sampling, amniocentesis or cordocentesis. We report a case of prenatally diagnosed PKS with unique dysmorphic feature: bifid cardiac apex, a type of morphology that has not been documented ever before in the literature. Case report:. Our patient is the 38-year-old pregnant woman who underwent amniocentesis at 18 weeks and 1 days’ gestation upon of an ultrasonographic imaging of fetal cleft lip and advanced maternal age. Cytogenetic analysis of amniotic fluid detected a male mosaic karyotype with a supernumerary chromosome (SMC) in 18/28 (64%) of fetal amniocytes. To determine the chromosomal origin of SMC, fluorescence in situ hybridization (FISH) was performed on metaphase spread chromosomes and mosaicism of tetrasomy 12p was confirmed: mos 47, XY, +mar[18]/46, XY[10].ish i(12p)(8M16/SP6++, CEP12+, VIJyRM2196-). Ultrasound examination showed a male fetus with abnormal facial profile, an echogenic focus in the left ventricle of the heart and shortened fetal long bones. After receiving a genetic counseling for established diagnosis of PKS, the woman requested a termination of pregnancy due to medical reasons. A postmortem inspection and autopsy of the fetus revealed a complex heart anomaly that includes bifid cardiac apex and ventricular septal defect. Conclusion: This report expands the clinical manifestations of PKS with a unique feature of bifid cardiac apex, and highlights the targeted diagnosis of Pallister-Killian syndrome in a second and third trimester of pregnancy if specific ultrasound markers are present.
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- 2019
17. Characteristics of fetal growth in the population of south-west Croatia
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Smajla, Nataša, Petrović, Oleg, Frančišković, Vedran, and Krajina, Robert
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fetal biometry ,fetal growth ,ultrasound ,Republic of Croatia - Abstract
The aim of this work was to define nomograms and standards of fetal biometric parameters in the population of pregnant women in southwest region of Croatia. Study design and Methods. During the nine-year period from 1st January 2002 to 31st December 2010 ultrasound examination was performed on 1594 pregnant women with singleton uncomplicated pregnancy between 22nd and 41st gestation week. In total, 2728 ultrasound measurements were performed. Measurement were obtained for biparietal diameter, femur length, abdominal circumference and the transverse cerebellar diameter. The results were presented as mean values with standard deviations and percentiles. Results. Normal fetal biometry charts for own population of pregnant women in the southwest region of Croatia were constructed.
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- 2017
18. Maternal smoking during pregnancy and birth weight in European cohorts: The HEALS project
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Sanyal, Shreosi, Baldacci, S., Barros, H., Horvat, Milena, Hanke, W., Maio, S., Mazej, Darja, Polanska, Kinga, Petrović, Oleg, Prpić, Igor, Ramos, E., Špirić, Zdravko, Snoj Tratnik, Janja, Viegi, Giorgo, Annesi Maesano, Isabella, and Jaddoe, Vincent W.V.
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Maternal smoking ,pregnancy ,birth weight ,European cohorts ,The HEALS project - Abstract
Background: Several studies have indicated that tobacco smoking changes the intrauterine environment that largely affects fetal growth. Low birth weight due to maternal smoking has been found to increase with maternal diseases like diabetes, maternal weight gain and other associated complications. Additional plausible confounders such as, socio-economic status, ethnic groups, sex of the child, alcohol consumption etc. are also found to have a synergistic effect on birth- weight. The aim of this study was to assess the potential impact of maternal smoking during pregnancy on birth- weight, taking into account clinical information and other related factors. Methods: The study included 17383 individuals from different pre- existing cohorts ( EPITeen, Generation 21, REPROPL, CCM, PHIME and EDEN) across multi- centers of six European countries, namely Portugal, Poland, Italy, Croatia, Slovenia and France respectively. A stratified logistic regression analysis was performed to determine the association between birth-weight and maternal smoking habits. In addition to maternal diseases during pregnancy, the effect of maternal smoking on birth weight was simultaneously controlled for sex of child, maternal weight at the end of pregnancy, maternal drinking habits, ethnic group, work position and educational level of mother, and socio-economic crowding index. Due to the presence of missing values, maximum- likelihood method has been used for multiple imputation in the data. Results: 15.79% of the pregnant mothers were regular smokers, 8.15% of newborns weighed less than 2.5 kg at birth. 7.05% of infants were born with low birth-weight (LBW) in case of non-smoking mothers, whereas 12.44% of LBW infants were documented for mothers who smoked during pregnancy. The number of infants with LBW was found to rise with the increasing number of cigarettes smoked by the mothers during pregnancy. 8.02%, 8.92% and 9.25% of LBW was observed when mothers smoked up to 5, 11 and greater than 11 cigarettes per day respectively. Maternal weight was also found to affect birth weight prominently (OR= 1.06 ; 95% CI = 1.02, 1.11), along with other factors like infectious diseases during pregnancy. After adjusting for confounders, maternal smoking during pregnancy had a significant association with LBW (OR= 1.95 ; 95% CI=1.58, 2.22). Similar findings were observed when sub-samples of the data were considered on the basis of geographic origins. Conclusions: Using large data from pre-existing cohorts of different European countries, our study confirms a prominent birth weight reduction with maternal smoking. This finding supports the biological explanation of placental deformation due to smoking that leads to reduced birth weight and other neonatal complications.
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- 2017
19. Associations between apolipoprotein E genotypes and Hg concentrations in cord blood
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Trdin, Anja, Falnoga, Ingrid, Snoj Tratnik, Janja, Stajnko, Anja, Mazej, Darja, Marc, Janja, Krsnik, Mladen, Osredkar, Joško, Prpić, Igor, Petrović, Oleg, Špirić, Zdravko, Horvat, Milena, and Manno, Maurizio
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apolipoprotein E, genotypes, Hg concentrations in cord blood - Abstract
The aim of present study was to estimate the potential relations between APOE polymorphisms and concentrations of total, methyl and inorganic Hg (tHg, MeHg, iHg) in cord blood (CB) of newborns whose mothers were exposed to Hg through fish consumption. We were focused on impact of APOE polymorphism of mothers and/or their newborns, since it is not clear whose genotypes could have greater impact on placental toxicokinetics. Mothers (n=398) and newborns (n=573) from central Slovenia and coastal Croatia, participants of EU projects PHIME and CROME-LIFE+, were included in the study. We used existed data set of personal (and lifestyle) characteristics, tHg blood concentrations and archived DNA extracts from maternal leukocytes and cord tissues. CB MeHg was additionally measured by CVAFS (Tekran 2700), iHg estimated by subtraction of MeHg from tHg and DNA genotyped for APOE (rs429358 and rs7412) by TaqMan® SNP assay (Applied Biosystems). Statistics: Wilcoxon rank-sum test, multiple linear regression (STATA).
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- 2017
20. A critical appraisal and potentially new conceptual approach to screening and diagnosis of gestational diabetes
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Petrović, Oleg, primary and Belci, Dragan, additional
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- 2017
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21. Učestalost peripartalnih histerektomija u pet hrvatskih bolnica tijekom šesnaestogodišnjeg razdoblja
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Haller, Herman, Hardi Dugandžić, Vedrana, Krištofić, Ines, Glavan Gačanin, Lana, Vukčević, Indira, Milčić, Hermina, Prka, Matija, Paljušaj, Edmnond, Drageljević, Ksenija: Štajcer, Željka, Habek, Dubravko, Belci, Dragan, Petrović, Oleg, Kolak, Nikola, Mišković, Berivoj, and Zoričić, Davor
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postpartalno krvarenje - epidemiologija, etiologija, kirurgija ,porođajne komplikacije - epidemiologija, etiologija, kirurgija ,histerektomija - statistički podatci ,Carski rez - statistički podatci, komplikacije ,vaginalni porod - statistički podatci, komplikacije ,Hrvatska - epidemiologija ,retrospektivne studije - Abstract
Uvod: Peripartalna histerektomija (PPH) najdramatičniji je kirurški zahvat u modernoj opstetriciji i obično se obavlja kada se konzervativnim mjerama nije uspjela postići kontrola krvarenja. Navodi se trend porasta učestalosti u razvijenim zemljama. Cilj rada: Odrediti učestalost PPH u pet hrvatskih bolnica tijekom dvaju osmogodišnjih razdoblja u odnosu prema načinu dovršenja porođaja. Metode: Retrospektivnom analizom prikupljeni su podaci iz pismohrana pet hrvatskih bolnica. U istraživanje su uključeni svi porođaji podijeljeni u dva osmogodišnja razdoblja, od 1998. do 2013. Rezultati: Od ukupno 153.302 porođaja tijekom obaju promatranih razdoblja u 70 (0, 46‰) slučajeva učinjen je hitni PPH. PPH nakon vaginalnog porođaja u prvom razdoblju iznosio je 0, 21‰, a u drugom razdoblju 0, 16‰. Učestalost PPH nakon carskog reza u prvom razdoblju iznosio je 1, 91‰, a u drugom razdoblju 2, 04‰. Rasprava i zaključak: Nema porasta pojavnosti PPH usporedbom dvaju osmogodišnjih razdoblja premda postoji statistički značajan porast učestalosti carskog reza (s 14, 2% na 16, 0%). Carski je rez čimbenik rizika za PPH
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- 2015
22. DO WE NEED TO DIFFERENTIATE BETWEEN COMPLICATION AND MALPRACTICE?
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Petrović, Oleg
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Expert testimony ,Malpractice ,Medical errors - Abstract
U radu se postavlja pitanje o opravdanosti i svrhovitosti odlučivanja između medicinske komplikacije i stručne pogreške, koje se posljednjih godina učestalo spominje među liječnicima, na sudskim raspravama i u medijima. Definirajući jasno pojmove medicinske komplikacije i stručne liječničke pogreške, autori ističu da su oni posve različita »pojmovnog ranga«, da nije realno odlučivati u praksi između spomenutih pojmova, kao i to da ih ne treba promatrati samo kao obligatno zavisne varijable. Samo ako se između njih temeljem sudskomedicinskog vještačenja dokaže uzročno-posljedična veza, nastala medicinska komplikacija može se proglasiti izravnom posljedicom stručne pogreške. U radu se spominju mogući uzroci i okolnosti nastanka stručnih pogrešaka. Osobito se ističe činjenica da ne treba svaku štetnu posljedicu ili loš ishod automatizmom poistovjećivati sa stručnom pogreškom te da je prijeko potrebno kvalitetnim medicinskim vještačenjem nadležnog kliničara jasno utvrditi sve okolnosti nastanka štete. Autori se zalažu za napuštanje dosadašnje pogrešne koncepcije odlučivanja između komplikacije i stručne pogreške te što skorije uvođenje novog, boljeg koncepta primarnog utvrđivanja komplikacije kao općenito neželjene, nepovoljne i štetne posljedice, dok bi za postojanje stručne pogreške i njezine eventualne povezanosti s nastalom komplikacijom trebalo objektivno i pomno provesti nadležno medicinsko vještačenje uvjeta, mehaniz(a)ma i/ili uzroka nastanka komplikacije., The paper discusses the issue of justifiability and practical value of deciding between a medical complication and a medical error, the subject which has recently been frequently debated among doctors, at court trials and in media. The authors clearly define the meaning of the terms of medical complication and medical error, pointing out that they belong to an entirely different class of terms and further stating that it is not realistic to decide between them in practice. They go on to emphasise that they should be viewed exclusively as obligatory dependent variables. Medical complication may be declared to be a direct consequence of medical error only when forensic and medical expert reports have established a causal relationship between the two. The paper proposes possible causes and circumstances in which medical complications may occur. Special emphasis is given to the fact that not every adverse event or harmful outcome should be automatically identified as medical error. In order to make such identification, all circumstances leading to an adverse outcome need to be clearly established through expert medical expertise. Instead of conclusion, the authors advocate abandonment of existing erroneous concept of deciding between complication and error and the introduction of a new and better concept that views complication as generally undesirable, adverse and harmful consequence while, in order to decide on the occurrence of medical error and possible link with the resulting complication, an objective and thorough forensic and medical expertise on the mechanism(s) and/or causes of the complication is required.
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- 2013
23. Fetal exposure to methyl-mercury and maternal fish consumption habits
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Prpić, Igor, Bilic-Čače, Iva, Petrović, Oleg, Špirić, Zdravko, Horvat, Milena, Bilić-Zulle Lidija, Valent, Francesca, Milardović, Ana, Radić, Jelena, and Vukelić, Petar
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Fetal exsposure ,methyl-mercury ,fish consumptions - Abstract
U radu se govori o izravnoj vezi između unosa namirnica morskog porijekla i koncentracija ukupne i metil-žive u krvi pupkovine.
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- 2012
24. Very early prenatal diagnosis of large isolated thoracic enteric cysts and review of the literature : case report
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Petrović, Oleg, Frančišković, Vedran, Štifter, Sanja, and Brajenović-Milić, Bojana
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isolated thoracic enteric cysts ,prenatal diagnosis - Abstract
This is the first case of an early prenatal diagnosis of isolated thoracic enteric cysts, with very clear evidence of a direct connection between the cysts, as well as the pleural and peritoneal cavities, at the early stages of embryological development. Based on the diff erent morphologies and histologies between postnatally and prenatally detected cases, we can only speculate that these cysts would have had great developmental changes during fetal life. A possible clinical solution for the very early prenatal diagnosis of large thoracic enteric cysts, which could result in lung hypoplasia, fetal hydrops and have poor prognosis, is to allow the termination of such a pregnancy. However, evolution of the cystic lesions could also be followed at any time before the abortion time limit, while waiting for a defi nitive decision, because the vital prognosis is different in cases of small isolated cysts that can be managed conservatively. Considering the small number of cases worldwide and the great spectrum of congenital thoracic abnormalities, qualitative antenatal and postnatal counselling of the family should be on a case-by-case basis. All the reported cases of this very rare abnormality are helpful in clarifying the aetiology, incidence and relationship between the initial phases of embryological development and the developed tumour-like cystic masses.
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- 2012
25. Breech Delivery - Mode of Delivery and Early Neonatal Outcome
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Marić, Marinko, Petrović, Oleg, Sindik, Nebojša, and Haller, Herman
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vaginal birth ,porod u stavu zatkom ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,caesarean section ,perinatalni ishod ,vaginalni porod ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,carski rez ,breech presentation ,neonatal outcome - Abstract
Cilj rada. Utvrditi postojanje razlika u ranom neonatalnom ishodu novorođenčadi vezano uz način dovršenja trudnoće. Ispitanice i metode. Ispitivanu skupinu sačinjavalo je 998 rodilja/trudnica koje su u Klinici za ginekologiju i porodništvo KBC-a Rijeka rodile u stavu zatkom u razdoblju od 1.siječnja 2000. do 31. prosinca 2010. godine. Iz ispitivanja su isključene sve višeplodove trudnoće, svi porodi prije navršenog 37. tjedna trudnoće i svi slučajevi kasne fetalne smrti, a rodilje bile su prema načinu dovršenja trudnoće podijeljene u tri skupine: vaginalni porod, elektivni carski rez i hitni carski rez. Rezultati. Niskom Apgar ocjenom (API, A breech presentation is a presentation abnormality, in which the breech of the fetus in a longitudinal lie is the presenting part in the birth canal, whereas its head is situated in the fundus of the uterus. In 3–4% of all single pregnancies the fetus will be in breech presentation at term. Objectives. This clinical research was conducted in order to establish the existence of differences in early neonatal outcomes in newborns. Patients and methods. A total of 998 parturient/pregnant women were monitored and gave birth of the fetus in breech presentation during the mentioned clinical research at the Clinic for Gynaecology and Obstetrics of the Clinical Hospital Centre in Rijeka, between January 1, 2000 and December 31, 2010. In order to achieve the consistency of data and results as well as the objectivity of clinical deductions, all the multiple pregnancies, all the deliveries before the 37 weeks gestation and all the late fetal deaths were excluded from the research. All parturient/pregnant women were, based on the mode of delivery, divided into three groups (vaginal birth, elective caesarean section, and urgent caesarean section). The evaluation of perinatal outcome was based on the analysis of the fetal sex, its weight, length and head circumference, Apgar score at 5 minutes after birth, admission to and length of stay in the intensive care unit, and early neonatal morbidity. All data for each of three groups were compared and statistically analyzed by the statistic data processing program Statistica 7.1 (Stat.Soft.Inc.) Results. From altogether 998 breech deliveries 595 (59,6%) were assigned to vaginal birth, 296 (29,7%) were assigned to urgent caesarean section and 107 (10.7%) to elective caesarean section. Within the selected group of 998 single pregnancies the frequency of vaginal birth was rising during eleven years of research and reached its peak in the year 2007 (74,2%). The age and the parity of women had no influence on the choice of delivery mode. Regardless the mode of delivery in cases of breech presentation – vaginal birth, urgent or elective caesarean section birth, no statistically significant differences were established regarding the perinatal outcome and early neonatal morbidity (birth trauma, frequency of reanimation procedures, neurological damages, and duration of stay in the NICU). Conclusions. No significant differences were shown in the early neonatal outcome, although newborns after elective caesarean section had best neonatal outcome. During the observation period appeared no cases of neonatal or maternal mortality in any of three analysed groups of pregnancies/deliveries
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- 2012
26. The association of mercury, fish consumption and child development in a Mediterranean cohort
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Barbone, Fabio, Valent, Francesca, Mazej, Darja, Tratnik, Janja, Špirić, Zdravko, Igor, Prpić, Igor, Sofianoukatsoulis, Aikaterini, Nakou, Sheena, Little, D’Anna, Mariuz, Marika, Miklavčić, Ana, Neubauer, David, Rosolen, Valentina, Petrović, Oleg, Parpinel, Maria, Bin, Maura, Tognin, Veronica, Carrozzi, Marco, Osredkar, Joško, Horvat, Milena, and Alexandra Steffen et all.
- Subjects
mercury ,fish consumption ,child development ,Mediterranean - Abstract
The effects of prenatal mercury exposure through fish consumption on neurodevelopment have been studied in several populations. Yet, findings have been inconsistent, particularly when assessing the effects of exposure to low mercury levels. To assess the effect of low-level prenatal mercury exposure through fish consumption on neurodevelopment among residents in Mediterranean regions of Italy, Slovenia, Croatia and Greece, we conducted a prospective cohort study within PHIME, a research project of EU Sixth Framework. Main exposures were total mercury (THg) and methylmercury (MeHg) concentration in mother’s hair in pregnancy and in cord blood, and mother’s fish intake in pregnancy. Child’s neurodevelopmental outcomes were Bayley III composite cognitive, language, and motor scores at 18 months. Covariates included pregnancy history, socioeconomic status, child characteristics, breastfeeding, childcare, etc. Data were analyzed with multivariate linear regression. 2189 mothers were enrolled in the study during pregnancy. 1729 mother-child pairs provided information at child’s birth. Follow-up at 18 months was 85%. The distribution of mother’s hair THg (ng/g) was: mean 1023, median 729, 25pct 396, 75pct 1270, mean ratio MeHg/THg 0.90. Cord blood THg (ng/g) was: mean 5.39, median 3.75, 25pct 1.87, 75pct 6.87, mean ratio MeHg/ THg 0.91. Spearman’s correlation between THg in hair and cord blood was: r=0.81, p
- Published
- 2011
27. Functional Inference of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Enzyme Stability as a Potential Risk Factor for Down Syndrome in Croatia
- Author
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Vraneković, Jadranka, Babić Božović, Jadranka, Starčević Čizmarević, Nada, Buretić-Tomljanović, Alena, Ristić, Smiljana, Petrović, Oleg, and Kapović, Miljenko
- Subjects
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics, Genomics and Proteomics ,Down syndrome ,Enzyme configuration ,MTHFR ,polymorphisms ,BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika, genomika i proteomika čovjeka - Published
- 2010
28. MOTHER’S SINUS TACHYCARDIA AS A CAUSE OF UNRECOGNIZED FETAL DEATH
- Author
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Petrović, Oleg, Sindik, Nebojša, Štimac, Tea, and Randić, Ljiljana
- Subjects
late fetal death ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,sinus tachycardia ,sinusna tahikardija ,gestational diabetes ,cardiotocography ,kardiotokografija ,gestacijski dijabetes ,kasna fetalna smrt - Abstract
U radu je opisan rijedak slučaj neprepoznate fetalne smrti u 39. tjednu trudnoće u mlade rodilje sa sinusnom tahikardijom. Tijekom detaljne analize ovog opstetričkog slučaja identificirane su subjektivne pogreške stručnog osoblja koje je zanemarilo neke postupke opstetričke propedeutike, ali su opažene i neke objektivne okolnosti koje su otežale dijagnozu kasne fetalne smrti, prije svega postojanje sinusne tahikardije, kojoj je trudnica bila sklona. Nesretnu okolnost autori su našli i u činjenici da je »CTG krivulja« sa snimljenom srčanom akcijom majke tijekom prijema u rađaonicu bila vrlo slična uobičajenoj krivulji s registriranim fetalnim srčanim otkucajima, pa je došlo do tragične zamjene. Autori apeliraju na stalan opstetričarov oprez, kritičko kliničko promišljanje i potrebu za preispitivanjem pojedinih stručnih odluka, osobito ako su tijekom analize prepoznate neke kliničke sumnje i nelogičnosti., Late fetal death was and still is a very sad and disappointing outcome of pregnancy. However, today, with all the classic and modern facilities at our disposal, it is really unacceptable that late fetal death remains unrecognized by qualified medical professionals at the beginning of labor. The authors have decided to present such an extremely rare case of unrecognized fetal death at the 39th week of singleton pregnancy in 19 years old primipara with sinus tachycardia which was recorded by external electronic fetal heart monitoring and mistakenly interpreted as normal fetal heart rate. The lack of timely diagnosis of gestational diabetes probably had resulted in undesirable fetal complications such as metabolic disorders, macrosomia and intrauterine fetal death, caused by fetal hypoxia and acidosis. Analysing the whole course of delivery a few fundamental obstetric rules were omitted: taking the patient’s medical history was done quite inadequately (nobody asked her about previous attack of tachycardia and fetal movements), and the simple auscultation of the fetal heartbeat with simultaneous checking of the maternal radial pulse rate was ignored, leading to an unacceptable situation, where intrauterine fetal death was unrecognized through the first 3 hours of labor. The authors offer a clinical opinion that the obstetricians, as well as midwifes have to use modern medical technology and diagnostic tests wisely and critically, but can never allow themselves to skip the simple propaedeutic rules of obstetric care. Only with the better collaboration of the patient and with a watchful and critical analysis of the complete medical documentation and diagnostic tests, it could be possible to correct possible own or somebody else’s professional errors.
- Published
- 2010
29. Relationship between prenatal exposure to mercury and the size of newborn's cerebellum
- Author
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Milardović, Ana, Prpić, Igor, Bilić, Iva, Petrović, Oleg, Špirić, Zdravko, Horvat, Milena, Tratnik, Janja, and Mazej, Darja
- Subjects
Methyl mercury ,size of the newborn’ s cerebellum ,prenatal exposure - Abstract
Methyl mercury, formed by methylation of mercury, is highly toxic and readily absorbed by the body following ingestion of the marine origin food products. Developing fetus, particularly its central nervous system, is more vulnerable to the exposure to methyl-mercury.The AIM of the study was to asses the correlation between prenatal exposure to low levels mercury and the size of the newborn’ s cerebellum. Prospecitively 137 childbearing women with non-complicated term pregnancies were included in the study. Maternal hair has been used as a vehicle for measuring prenatal exposure to mercury. Majority of the sample consisted of mothers with lower hair levels of mercury (< 1 mcg/g) whose newborns had greater mean values of length and width of cerebellum compared to those whose mothers had higher hair levels of mercury. However difference did not reach the level of statistical significance.
- Published
- 2009
30. Hypertensive Disorders in Pregnancy: A 5-year Analysis of the Wartime and Postwar Period in South-Western Region of Bosnia and Herzegovina
- Author
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Tomić, Vajdana, Petrović, Oleg, Petrov, Božo, Bjelanović, Vedran, and Naletilić, Mladenka
- Subjects
Adult ,Male ,Warfare ,Pregnancy ,Risk Factors ,Humans ,risk factors ,war ,hypertensive disorders ,postwar ,Retrospective Studies ,Bosnia and Herzegovina ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,Infant, Newborn ,Pregnancy Outcome ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,Prenatal Care ,Hypertension, Pregnancy-Induced ,Logistic Models ,perinatal outcome ,prenatal care ,Case-Control Studies ,Multivariate Analysis ,Female - Abstract
Hypertensive disorders are among the most common complications in pregnancy and a major cause of perinatal morbidity and mortality. The aim of this study was to investigate the risk factors and adverse perinatal outcomes of pregnancies in mothers with hypertensive disorders, as well as the adequacy of prenatal care during the wartime and postwar period in South-Western region of Bosnia and Herzegovina. This study included a total of 542 pregnancies with hypertensive disorders during 5-year study period (1995–1999) and 1559 randomly selected controls. Data on risk factors, adverse perinatal outcomes (for singleton pregnancies only) and prenatal care on pregnant women were extracted from the medical records and compared with controls. Chi-square test and crude odds ratio (OR) with 95% confidence interval (95% CI) were used in statistical analysis. The average five-year incidence of hypertensive pregnancy disorders was 6.5% and it was significantly higher in 1995, the last year of the war, than in the postwar period (1996–1999) (p=0.02). Factors significantly associated with hypertensive pregnancy disorders were maternal age >34, nulliparity, multifetal gestation and male newborn (p
- Published
- 2009
31. Size of a newborn’s cerebellum in relation with prenatal exposure to mercury
- Author
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Špirić, Zdravko, Prpić, Igor, Milardović, Ana, Bilić, Iva, Krajina, Robert, Petrović, Oleg, Horvat, Milena, Tratnik, Janja, Mazej, Darja, and Heindel, Jerrold et al.
- Subjects
prenatal ,exposure to mercury ,newborn’s cerebellum - Abstract
A prospective study, as extended part of the PHIME study, has been conducted and a total of 137 childbearing women with term, singleton, and uncomplicated pregnancies were included. Maternal hair has been used as a vehicle for measuring prenatal exposure to mercury. Neurosonographic examination was conducted to all newborns and length and width of cerebellum were measured. Women were divided based on their hair levels of methyl-mercury: ≥ 1 mcg/g vs. < 1 mcg/g and their newborns were compared. Mean value of mother’s hair mercury level was 880, 9 mcg/g, ranging from 19 mcg/g to 8710 mcg/ g. with 107 mother with levels < 1 mcg/g. Comparison between the group of newborns born to mothers with levels of mercury ≥ 1 mcg/g and those born to mothers with levels of mercury < 1 mcg/g revealed that there were no significant differences between the two groups considering the width of cerebellum. Mean values of the length of cerebellum were 24, 6 (SD 2.8) and 25, (SD 3, 3), respectively. Statistical analysis revealed no significant difference between the groups related to the length of cerebellum. However obtained result was at the borderline significance (p=0.06). Obtained preliminary results show that majority of our sample consisted of mothers with lower hair levels of mercury (< 1 microgram/g) whose newborns had greater mean values of length and width of cerebellum compared to those whose mothers had higher heir levels of mercury. However difference did not reach the level of statistical significance.
- Published
- 2009
32. Longitudinal cohort study of prenatal exposure to mercury in the Meditteranean region
- Author
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Little, Danna, Barbone, Fabio, Horvat, Milena, Mariuz, Marika, Nakou, Sheena, Parpinel, Petrović, Oleg, Prpić, Igor, Sofianou, Katia, Špirić, Zdravko, Tamburlini, Tratnik, Valent, Kuljanić-Vlašić, Karin, and Vlašić-Cicvarić, Inge
- Subjects
prenatal exposure ,mercury ,meditteranean region - Abstract
Istraživana je prenatalna izloženost živi na Mediteranu.
- Published
- 2009
33. Mercury measurements in pregnant women hair samples in Croatia
- Author
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Špirić, Zdravko, Petrović, Oleg, Horvat, Milena, Prpić, Igor, Haller, Herman, Kuljanić-Vlašić, Karin, Vlašić-Cicvarić, Inge, Tratnik, Janja, and Mazej, Darja
- Subjects
mercury measurements ,pregnant women ,hair samples - Abstract
Vršena su mjerenja razine žive iz uzoraka kosa trudnica u Hrvatskoj.
- Published
- 2009
34. Prenatal exposure to mercury and the size of newborn¨s cerebellum
- Author
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Prpić, Igor, Milardović, Ana, Bilić, Iva, Krajina, Robert, Petrović, Oleg, Špirić, Zdravko, Horvat, Milena, Tratnik, Jana, Mazej, and Lieven Lagae
- Subjects
mercury prenatal exposure ,newborns cerebellum ,neurosonographic examination - Abstract
The aim of the study was to assess the correlazion between prenatal exposure to low levels of mercury and the size of the newborns cerebellum.
- Published
- 2009
35. MYOPIA AND DELIVERY. Should mode of delivery be influenced by moderate and high myopia?
- Author
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Petrović, Oleg, Prodan, Mirko, Lončarek, Karmen, Zaputović, Sanja, and Sindik, Nebojša
- Subjects
vaginal birth ,cesarean section ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,instrumental delivery ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,miopija ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ortopedija ,term pregnancy ,terminska trudnoća ,vaginalni porod ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Orthopedics ,myopia ,instrumentalni porod ,carski rez - Abstract
Cilj rada. Mnogi oftalmolozi i opstetričari još uvijek za dovršenje trudnoće odnosno poroda u žena s visokom miopijom preporučuju carski rez ili instrumentalni vaginalni porod, iako za to nema valjanih medicinskih dokaza. Budući da je u zdravstvenoj ustanovi autora došlo do promjene doktrine prema kojoj visoka miopija više nije predstavljala indikaciju za elektivni carski rez, cilj rada bio je istražiti je li spomenuta promjena imala ikakve implikacije glede zdravlja, osobito vida rodilje i perinatalnog ishoda. Namjera autora bila je dati preporuke glede stručnog postupanja s trudnicama i rodiljama koje imaju problem s umjerenom i visokom miopijom. Metode. U retrospektivnoj petogodišnjoj studiji međusobno su uspoređene skupine rodilja s niskom, umjerenom i visokom miopijom glede načina dovršenja jednoplodne terminske trudnoće i perinatalnog ishoda s osobitim osvrtom na eventualnu progresiju retinalnih promjena u majki neposredno nakon poroda. Rezultati. Studija je obuhvatila 240 rodilja, od čega 137 s niskom, 54 s umjerenom i 49 s visokom miopijom. Učestalost carskog reza iznosila je u prvoj ispitivanoj skupini 11%, u drugoj 14,8%, dok je u skupini rodilja s visokom miopijom učestalost carskog reza iznosila tek 10,2%. Između spomenutih rezultata nije bilo statistički znakovitih razlika, kao što ih nije bilo ni u odnosu na prosječnu učestalost carskog reza u Klinici u istraživanom razdoblju, koja je iznosila 10,1%. Ni jedan carski rez kao elektivni zahvat nije izvršen zbog miopije rodilje, bez obzira na njezinu vrijednost. Učestalost vakuum ekstrakcije u prvoj skupini rodilja s niskom miopijom bila je 5,1%, među rodiljama s umjerenom miopijom 1,9%, dok je učestalost vakuum ekstrakcije u skupini ispitanica s visokom miopijom iznosila 12,2% i bila je statistički znakovito viša u odnosu na učestalost u prve dvije skupine rodilja te u odnosu na prosječnu učestalost vakuum ekstrakcije u Klinici od 1,9% u istom razdoblju. Ni u jedne od skupina istraživanih rodilja nije nastala ablacija retine ni bilo koji drugi ozbiljan poremećaj vida. Zaključak. Uz gotovo jednaku učestalost carskog reza u skupinama rodilja s normalnim vidom, niskom, umjerenom i visokom miopijom nije se dogodio ni jedan slučaj akutnog pogoršanja vida u rodilje. Autori zaključuju da je spontani vaginalni porod kao prva opcija siguran način rađanja za rodilje s umjerenom i visokom miopijom te da planski carski rez u takvim slučajevima nikako nije opravdan., Objective. Many obstetricians and ophthalmologists recommend in cases of preexisting high myopia either a cesarean section or an instrumental vaginal delivery, although these recommendations are not evidence based. According to a changed professional policy at author’s Department, moderate and high myopia were not indications for an elective operative delivery any more (since 2003). The aim of the study was to investigate did a changed obstetric policy had any implication on patient’s health, especially on vision condition, and perinatal outcome. Authors decided to give recommendations regarding optimal mode of delivery of pregnant women with moderate and high myopia. Methods. In a 5-year retrospective study a comparison between three groups of pregnant patients with low, moderate and high myopia regarding a mode of delivery of term single pregnancies and perinatal outcome is presented. Authors were interested particularly on eventual progression of retinal changes in mothers after deliveries. Results. The study encompassed 240 pregnant women. Out of total there were 137 patients with low myopia, 54 patients with moderate myopia, and 49 patients were highly myopic. The incidences of cesarean section in the studied groups of women were 11%, 14.8%, and 10.2%, respectively. There were not statistically significant differences either among the mentioned results or in relation to an average incidence of cesareans during the same study period, which was 10.1%. Not even a single elective cesarean was performed due to patient’s myopia of any degree. The incidences of instrumental vaginal deliveries with vacuum extraction were 5.1% in the group of women with low myopia, 1.9% in the group of patients with moderate myopia, and 12.2% in highly myopic group. The last result was significantly higher than the percentages of vacuum extractions in patients with low and moderate myopia, and in relation to an average incidence of vaginal deliveries with vacuum extraction during the same study period, which was 1.9%. Not a single case of either a retinal detachment or any other vision disturbance was recorded. Conclusion. With almost identical rates of cesarean section reported in the groups of eumetropic, low, moderate and high myopic puerperas, there was not even a single case of acute deterioration of patient’s visus. Authors concluded that spontaneous vaginal birth as a first option is an accurate mode of delivery for women with moderate and high myopia, and in those cases planned cesarean section is not justified.
- Published
- 2009
36. Detection of pregnancy methemoglobinemia with a fast, noninvasive, continuous and inexpensive method using Masimo pulsE co-oximeter Rainbow RAD57 - the result of the pilot study
- Author
-
Mohorović, Lucijan, Petrović, Oleg, and Haller, Herman
- Subjects
methemoglobin ,pregnancy - Abstract
The role of methemoglobin (MetHb) during pregnancy is often unrecognized and underemphasized by obstetricians. The confirmation of this is the lack of research concerning MetHb as the biomarker of adverse effects of oxidative stress and its prooxidant property. The aim of this epidemiological research is to evaluate a direct, new, noninvasive and continuous measurement which will facilitate the useful detection of potentially life-threatening acquired methemoglobinemia and risk pregnancy. Measurements were carried out on 346 women with complicated pregnancy, who were admitted to the Department of Fetomaternal Medicine at the University Hospital in Rijeka, Croatia during 2007. The admitted pregnant women were monitored with the new Masimo eight-wavelength Pulse Co-Oximeter Rainbow-Set Rad57 sensor. We set the limit of the normal level of maternal methemoglobin under or up to 1%, according to the quotations in recent literature. Measurements have shown that among 4 cases (1.16%) with 1% or more than 1% of MetHb, there was one case of stillbirth during the 30th week of pregnancy, which is statistically significant ( P= 0.0116) in relation to the pregnancies with the concentration of MetHb lower than 1%. Methemoglobinemia is a pervasive and significant clinical condition. Maternal mortality and perinatal loss are major unsolved problems, from the social, economical and medical point of view, particularly in underdeveloped countries. The ability of using the noninvasive, continuous and inexpensive method to evaluate MetHb enables this method to become a powerful diagnostic tool, when compared to the limited availability of current laboratory standard of measurement, the invasive CO-Oximetry.
- Published
- 2008
37. Prenatal exposure to methyl-mercury and postnatal neurodevelopment
- Author
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Prpić, Igor, Krajina, Robert, Bilić, Iva, Karavida, Inge, Mahulja-Stamenković, Vesna, Peter, Branimir, Petrović, Oleg, Špirić, Zdravko, and Howard Bauchner
- Subjects
methyl-mercury ,postnatal neurodevelopment - Abstract
Promatrane su neurorazvojne karakteristike novorođenčadi izložene niskim razinama metil-žive.
- Published
- 2008
38. TREATMENT OF THREATENED PRETERM LABOR
- Author
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Prodan, Mirko and Petrović, Oleg
- Subjects
threatened preterm labor ,treatment ,tocolytics ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,liječenje ,tokolitici ,prijeteći prijevremeni porod - Abstract
Sažetak. Prijevremeni porod je vodeći uzrok neonatalnog mortaliteta i morbiditeta i još uvijek jedan od najvećih problema i izazova suvremene perinatologije. Njegovo sprječavanje i liječenje je otežano zbog postojanja većeg broja uzročnih i rizičnih čimbenika koji su dijelom i nepoznati. U ovom prikazu razmotreni su različiti postupci i lijekovi za sprječavanje i liječenje prijetećeg prijevremenoga poroda. Posebno su analizirane pojedine skupine tokolitika, njihova učinkovitost i nedostatci. Oni mogu odgoditi porod za najviše 48 sati do sedam dana, ali bitno ne poboljšavaju perinatalni i neonatalni ishod. Taj vremenski period je, međutim, dovoljan za transport u tercijarni perinatološki centar i sprovođenje kortikosteroidne profilakse. Smatra se da je to jedini dokazan učinak tokolitičke terapije. Za sada, dok se ne otkriju bolji i učinkovitiji lijekovi i metode, kvalitetna i pravodobna antenatalna skrb, hospitalizacija pa i preventivna, u odabranim rizičnim slučajevima još uvijek najdjelotvornije smanjuju učestalost prematuriteta i njegovih neželjenih posljedica., Preterm labor is a leading cause of neonatal mortality and morbidity, and still remains the greatest problem and challenge for modern perinatology. Prevention and treatment of preterm labor is difficult due to multiple risk and ethiological factors, some of them also unknown. In this paper various methods of treatments and pharmacological agents for prevention and inhibition of threatened preterm labor are discussed. Particularly some groups of tocolytic agents, their efficacy, and adverse effects have been analyzed. Tocolytic agents can delay delivery for 48 hours up to seven days, but whithout improvements on perinatal and neontatal outcome. Prolonging gestation with tocolytic agents allows administration of antenatal glucocorticosteroids to reduce incidence and severity of respiratory distress syndrome and also to allow transport in utero in the tertiary perinatal center with neonatal intensive care unit. It is the only proven effect of tocolytic therapy. Up till now, the best quality of antenatal care, hospitalization sometimes also preventive, in some cases of high risk pregnancies is the most effective strategy in decreasing prematurity and adverse consequences.
- Published
- 2008
39. Impact of fish consuption habits on fetal brain development: a preliminary report
- Author
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Prpić, Igor, Lulić, Krajina, Robert, Ković, Ileana, Bilić, Iva, Karavida, Inge, Mahulja-Stamenković, Vesna, Peter, Branimir, Petrović, Oleg, and Špirić, Zdravko.
- Subjects
fish consuption habits ,fetal brain development - Abstract
Proučavane su prenatalne prehrambene navike rodilja i utjecaj hrane ribljeg porijekla na razvoj fetalnog mozga.
- Published
- 2008
40. SPONTANEOUS ABORTION AFTER ASSISTED REPRODUCTIVE TECHNOLOGY
- Author
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Finderle, Aleks and Petrović, Oleg
- Subjects
spontani pobačaj ,spontaneous abortion ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,assisted reproduction ,potpomognuta oplodnja - Abstract
Sažetak Spontani pobačaj je gubitak trudnoće prije navršenih 20 tjedana s težinom ploda manjom od 500 grama. Rana trudnoća nakon potpomognute oplodnje nosi povećan rizik za spontani pobačaj u odnosu na spontano započete trudnoće, a uzroci gubitka trudnoće, osim uobičajenih, imaju i određene specifičnosti. U etiologiji spontanih pobačaja spominju se genetski, anatomski, endokrinološki, upalni, imunološki i ostali čimbenici. U novije vrijeme, uvođenjem novih dijagnostičkih metoda, utvrđena je veća učestalost pojedinih uzroka spontanih pobačaja poput sindroma antifosfolipidnih protutijela, trombofilije i sl. Napretkom operacijskih i drugih metoda liječenja povećava se broj uzroka spontanih pobačaja koji se mogu uspješno liječiti., Spontaneous abortion is defined as pregnancy loss before 20 weeks gestation, as based on last menstral period, or the delivery of a fetus that weights less than 500 g. Early pregnancy after assisted reproduction has increased risk for spontaneous abortion in confront of spontaneous pregnancies. There is no difference in etiologies of spontaneous abortion after IVF and the most common are genetic, anatomic, endocrine, infectious, autoimmune and other causes. The frequency of clinically recognized abortion is about 15 to 20% and chromosomal abnormalities cause at least half of them. With genetic counseling and preimplantation genetic diagnosis there is a possibility to decrease number of spontaneous abortion coused by genetic causes. Recently, as a consequence of new diagnostic technologies development there is increase of some other causes of early pregnancy loss as a antiphospholipid synrome (APS) and thombophilia.
- Published
- 2007
41. Women with epilepsy – Reproductive health, pregnancy, delivery and newborn's outcome
- Author
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Prpic, Igor, Mahulja-Stamenkovic, Vesna, Petrovic, Oleg, Vukelic, Petar, Radic Nisevic, Jelena, Haller, Herman, Polic, Ljerka, and Ivandic, Jelena
- Published
- 2017
- Full Text
- View/download PDF
42. The influence of fetal sex, smoking and parity on AFP and free β -hCG concentrations in amniotic fluid of unaffected second-trimester pregnancies
- Author
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Brajenović-Milić, Bojana, Tišlarić, Dubravka, Petrović, Oleg, Prodan, Mirko, Ristić, Smiljana, Marout, Jasminka, Herman, Radoslav, and Kapović, Miljenko
- Subjects
amniotic fluid ,alpha-fetoprotein ,free β -hCG ,fetal sex ,parity ,smoking - Abstract
The aim is to investigate the influence of smoking, parity and fetal sex on AFP and free β -hCG in amniotic fluid and to inquire into a correlation between maternal serum and amniotic fluid marker concentrations. The study was performed on 233 second-trimester amniotic fluid samples. In 75 women, blood sample was taken immediately before amniocentesis. All pregnancies were singleton with normal fetal karyotype and outcome. Concentrations of AFP and free β -hCG were determined by fluoroimmunoassay and converted to MoMs, according to medians for unaffected pregnancies of the corresponding gestational age. In smoking women, amniotic fluid free β -hCG was significantly lower than in non-smoking ones (p=0.033), though AFP was not significantly different in regard to smoking habits (p=0.113). Significantly higher amniotic fluid free β -hCG (p
- Published
- 2007
43. Organizacija i učinkovitost prenatalne skrbi u Primorsko-goranskoj županiji
- Author
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Brajenović-Milić, Bojana, Vraneković, Jadranka, Babić, Ivana, Petrović, Oleg, Prodan, Mirko, Haller, Herman, Kapović, Miljenko, and Barišić, Ingeborg
- Subjects
amniocenteza ,biokemijski test probira za sindrom Down ,prevalencija sindroma Down - Abstract
Organizacija prenatalne skrbi u Primorsko-goranskoj županiji temelji se na primjeni neinvazivnih (biokemijski test probira za Downov sindrom-DS) i invazivnih metoda (rana amniocenteza-RAC) detekcije kromosomopatija u ploda tijekom drugog tromjesečja trudnoće. RAC se izvodi na Klinici za ginekologiju i opstetriciju, KBC Rijeka od 1986. godine, a biokemijski test probira za DS od 1996. godine na Zavodu za biologiju i medicinsku genetiku Medicinskog fakulteta Sveučilišta u Rijeci. Neinvazivno testiranje preporuča se svim trudnicama mlađim od 35 godina i neopterećene anamneze dok je RAC indicirana u starijih trudnica i onih s genetičkim opterećenjem. Aberirani kariotip utvrđen je u 2, 6% učinjenih RAC, a u 73% aberacija radilo se o numeričkoj promjeni kromosoma. Najčešća je bila trisomija 21 (69%). Preostalih 27% aberacija odnosi se na strukturne promjene kromosoma od kojih je 54% nastalo kao posljedica svježe mutacije (de novo) dok su ostale bile obiteljskog porijekla. U 23% strukturnih aberacija radilo se o nebalansiranoj promjeni. Stopa detekcije DS primjenom biokemijskog testa probira iznosila je 67%. Prevalencija DS u živorođenih u razdoblju 1996.-2005. godine iznosila je 1, 4/1000 dok je totalna prevalencija DS bila 2, 0/1000. Proporcija žena starijih od 35 godina iznosila je 11, 6%. U programu probira za DS sudjelovalo je 33, 9% trudnica, a na amniocentezu pristalo je 6, 1% žena. Primjenom neinvazivnih i invazivnih metoda detekcije DS utvrđen je pad incidencije DS u živorođenih za 18%.
- Published
- 2007
44. BIRTH WEIGHT AND LENGTH OF NEWBORNS AT UNIVERSITY HOSPITAL RIJEKA
- Author
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Prpić, Igor, Krajina, Robert, Radić, Jelena, Petrović, Oleg, Mamula, Ozren, Haller, Herman, Baždarić, Ksenija, and Vukelić-Šarunić, Alenka
- Subjects
newborns ,fetalni rast ,novorođenče ,porodna duljina ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,birth length ,birth weight ,porodna težina ,fetal growth - Abstract
Cilj rada. Izraditi tablice i analizirati standardne vrijednosti porodne težine i porodne duljine zdrave novorođenčadi. Ispitanici i metode. Retrospektivno su analizirani podatci o 19 996 novorođenčadi jednoplodnih trudnoća od 22. do 42. tjedna gestacije rođenih u Klinici za ginekologiju i porodništvo KBC Rijeka u razdoblju od deset godina. Iz analize su isključena novorođenčad s kongenitalnim malformacijama, mrtvorođeni, djeca majki s nesigurnim trajanjem trudnoće i majki s kroničnim bolestima. Rezultati su prikazani u tablicama i krivuljama centilnih vrijednosti prema navršenim tjednima trudnoće, paritetu majke i spolu novorođenčeta. Rezultati. Medijana vrijednost porodne težine u 40. tjednu trudnoće za analiziranu skupinu iznosila je 3580 g (c.10=3070 g; c.90=4140 g). Najnižu porodnu masu u 40. tjednu imala su ženska novorođenčad prvorotkinja, 3450 g (c.10=2980 g; c.90=3955 g). Slijede ženska djeca višerotkinja (3550 g) i muška djeca prvorotkinja (3590 g). Najteža su bila muška novorođenčad višerotkinja 3720 g. U 40. tjednu gestacije medijana vrijednost porodne duljine iznosila je 52 cm (c.10=49 cm; c.90=54 cm). Zaključak. Izrada antropometrijskih standarda na vlastitoj populaciji novorođenčadi preduvjet je za kvalitetnu skrb djeteta. Usporedba rezultata sa sličnim ¬studijama u zemlji otežena je zbog metodološki različitog pristupa u odabiru ispitanika. Zato je potrebno jedinstvenom metodologijom izraditi nacionalne standarde, kako bi se osigurao veći ispitivani uzorak, dobili objektivniji rezultati te omogućilo otkrivanje poremećaja fetalnog rasta., Aim. To present the obtained data as table records and to analyse standard values of birth weight and birth length in healthy newborns. Methods. Retrospective study of 19 996 singleton pregnancies' neonates with a gestational age between 22 to 42 weeks born at the University Hospital Rijeka, Department of Obstetrics and Gynecology, over the ¬period of ten years. Statistical evaluation of the hospital records data. Newborns with congenital disorders, stillborn ¬children, neonates born to mothers with uncertain pregnancy duration and those born to mothers with chronic diseases that may influence fetal growth (malignant and endocrine diseases, hypertension) were excluded. Obtained results have been presented in tables of percentiles, according to gestational age, mother's parity and neonatal gender. Results. Median birth weight value for the analysed group born at 40-th gestational week was 3580 gs (c10=3070 gs; c90=4140 gs). ¬Female neonates of primiparas, born at 40-th gestational week, had the lowest median birth weight, 3450 gs (c10=2980 gs; c90=3955 gs), followed by female neonates of multiparas (3550 gs) and male neonates of primiparas (3590 gs). Male newborns of multiparas had the greatest median birth weight, 3720 gs. Median birth length value at the 40-th gestational week for the analysed group was 52 cms (c10=49 cms; c90=54 cms). Conclusion. Construction of anthropometrical ¬standards in a certain population is essential condition for maintaining quality of antenatal and postnatal health care. ¬Eventual comparison of our results with similar studies in the country is difficult due to variant methodological ¬approaches considering the selection of examinees. It is essential to apply the unique methodology and create national standards, which would ensure greater examined sample and thus more objective results to enable further researches of fetal growth delays.
- Published
- 2007
45. UTJECAJ SPOLA FETUSA I PUŠENJA TE RODNOSTI MAJKE NA AFP I SLOBODNI beta-HCG U PLODOVOJ VODI UREDNIH TRUDNOĆA DRUGOG TROMJESEČJA
- Author
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Brajenović-Milić, Bojana, Tišljarić, Dubravka, Petrović, Oleg, Prodan, Mirko, Ristić, Smiljana, Marout, Jasminka, Herman, Radoslav, and Kapović, Miljenko
- Subjects
free beta-hCG ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,amniotic fluid ,alpha-fetoprotein ,fetal sex ,parity ,smoking ,pušenje ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,slobodni beta-hCG ,plodova voda ,alfa-fetoprotein ,spol fetusa ,paritet ,BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics, Genomics and Proteomics ,BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika, genomika i proteomika čovjeka - Abstract
Cilj istraživanja. (1) Ispitati utjecaj pušenja i rodnosti (pariteta) majke i spola fetusa na razinu alfa-fetoproteina (AFP) i slobodne beta-podjedinice humanog korionskog gonadotropina (slobodni beta-hCG) u plodovoj vodi urednih trudnoća. (2) Ispitati korelacije između serumskih vrijednosti AFP i slobodnog beta-hCG i vrijednosti spomenutih biljega u plodovoj vodi. Ispitanice i metode. Ispitivanje je provedeno na 233 uzorka plodove vode koji su dobiveni amniocentezom u drugom tromjesečju trudnoće. U 75 slučajeva uzet je i uzorak krvi neposredno prije amniocenteze. Sve su trudnoće bile jednoplodne, urednog tijeka i ishoda, a kariotip ploda bio je uredan. Koncentracije AFP i slobodnog beta-hCG određivane su fluoroimunometrijskom metodom i izražene u multiples of median (MoM) za odgovarajući tjedan trudnoće. Rezultati. U plodovoj vodi trudnica pušačica utvrđena je statistički značajno niža razina slobodnog beta-hCG nego u nepušačica (p=0,033). Utjecaj pušenja na razinu AFP u plodovoj vodi nije utvrđen (p=0,113). Nasuprot tomu, spol fetusa je značajno utjecao na razinu slobodnog beta-hCG i AFP u plodovoj vodi: razina slobodnog beta-hCG je bila statistički značajno viša, a AFP značajno niža ako je fetus bio ženskog spola (p0,05 za oba biljega). Statistički značajna korelacija utvrđena je za koncentracije AFP (r=0,61; p, Objective. The aim is to investigate the influence of mother’s smoking and parity and fetal sex on AFP and free beta-hCG in amniotic fluid and to examine the correlation between maternal serum and amniotic fluid marker concentrations. Methods. The study was performed on 233 second-trimester amniotic fluid samples. In 75 women, blood sample was taken immediately before amniocentesis too. All pregnancies were singleton with normal fetal karyotype and outcome. Concentrations of AFP and free beta-hCG were determined by fluoroimmunoassay and converted to MoM, according to medians for unaffected pregnancies of the corresponding gestational age. Results. In smoking women, amniotic fluid free beta-hCG was significantly lower than in non-smoking ones (p=0.033), though AFP was not significantly different in regard to smoking habits (p=0.113). Significantly higher amniotic fluid free beta-hCG (p
- Published
- 2007
46. Porodna težina i duljina novorođenčadi rođene u Kliničkom bolničkom centru Rijeka
- Author
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Prpić Igor, Krajina Robert, Radić Jelena, Petrović Oleg, Mamula Ozren, Haller Herman, Baždarić Ksenija, and Vukelić-Šarunić Alenka
- Subjects
fetalni rast ,novorođenče ,porodna težina ,porodna duljina - Abstract
Cilj rada. Izraditi tablice i analizirati standardne vrijednosti porodne težine i porodne duljine zdrave novorođenčadi. Ispitanici i metode. Retrospektivno su analizirani podatci o 19 996 novorođenčadi jednoplodnih trudnoća od 22. do 42. tjedna gestacije rođenih u Klinici za ginekologiju i porodništvo KBC Rijeka u razdoblju od deset godina. Iz analize su isključena novorođenčad s kongenitalnim malformacijama, mrtvorođeni, djeca majki s nesigurnim trajanjem trudnoće i majki s kroničnim bolestima. Rezultati su prikazani u tablicama i krivuljama centilnih vrijednosti prema navršenim tjednima trudnoće, paritetu majke i spolu novorođenčeta. Rezultati. Medijana vrijednost porodne težine u 40. tjednu trudnoće za analiziranu skupinu iznosila je 3580 g (c.10=3070 g ; c.90=4140 g). Najnižu porodnu masu u 40. tjednu imala su ženska novorođenčad prvorotkinja, 3450 g (c.10=2980 g ; c.90=3955 g). Slijede ženska djeca višerotkinja (3550 g) i muška djeca prvorotkinja (3590 g). Najteža su bila muška novorođenčad višerotkinja 3720 g. U 40. tjednu gestacije medijana vrijednost porodne duljine iznosila je 52 cm (c.10=49 cm ; c.90=54 cm). Zaključak. Izrada antropometrijskih standarda na vlastitoj populaciji novorođenčadi preduvjet je za kvalitetnu skrb djeteta. Usporedba rezultata sa sličnim ¬ ; studijama u zemlji otežena je zbog metodološki različitog pristupa u odabiru ispitanika. Zato je potrebno jedinstvenom metodologijom izraditi nacionalne standarde, kako bi se osigurao veći ispitivani uzorak, dobili objektivniji rezultati te omogućilo otkrivanje poremećaja fetalnog rasta.
- Published
- 2007
47. Lhermitte-Duclos disease and pregnancy
- Author
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Franko, Artur, Holjar-Erlić, Izidora, Miletić, Damir, and Petrović, Oleg
- Subjects
cerebellar neoplasms ,ganglioneurinoma ,magnetic resonance imaging - Abstract
Background. Lhermitte-Duclos disease or dysplastic gangliocytoma of the cerebellum is a rare disorder that can cause progressive mass effects to the structures occupying posterior fossa. Magnetic resonance imaging is a diagnostic modality of choice demonstrating characteristic non-enhancing gyriform pattern with the enlargement of cerebellar folia, hypointense on T1 and hyperintense on T2 weighted magnetic resonance images. Case report. The authors present a case of 37-year old woman with previously unknown Lhermitte-Duclos disease in the third trimester of pregnancy from the first signs of the disease to the first six months after delivery. Conclusions. Moreexperience will be needed with this disease in pregnancy and post deliveryperiod to recommend pregnancy for women with such condition. However, this case shows that a pregnant woman with Lhermitte-Duclos disease could reach full-term pregnancy and deliver a healthy child, without lifethreateningrisk. Izhodišča. Lhermitte-Duclosova bolezen ali displatični gangliocitom malih možganov je redka bolezen, ki lahko povzroča napredujočo tumorsko rast. Ugotovimo jo z magnetno resonanco, ki pokaže značilne neobarvane girusne spremembe, različne intenzitete na T1 In T2 magnetnih slikah. Prikaz primera. Opisujemo 37-letno bolnico, ki smo ji dokazali Lhermitte-Duclosovo bolezen v tretjem tromesečju nosečnosti. Zaključki. Prikazan primer kaže, da lahko nosečnica z Lhermitte-Duclosovo boleznijo brez življenjskega tveganja donosi in rodi zdravega otroka. Potrebnih pa je več izkušenj, da bi to opažanje lahkoposplošili.
- Published
- 2006
48. The clinical importance and surveillance of high-risk pregnancies
- Author
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Prodan, Mirko, Brnčić-Fischer, Alemka, Finderle, Aleks, and Petrović, Oleg
- Subjects
visokorizična trudnoća ,antenatal surveillance ,perinatal outcome ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija ,perinatalni ishod ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics ,high-risk pregnancy ,antenatalni nadzor - Published
- 2005
49. Ultrazvuk i perinatalni ishod
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Smiljan Severinski, Neda , Petrović, Oleg
- Subjects
ultrazvuk ,perinatalni ishod - Abstract
Prikazan je doprinos ultrazvuka u nadzoru uredne trudnoće, te je postavljeno pitanje o učinkovitosti ultrazvučnih pregleda obzirom na različite stavove iz literature o korisnosti i opravdanosti primjene ove tehnologije.
- Published
- 2005
50. Epilepsija i trudnoća - Primjena antiepileptika u trudnoći
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Šepić Grahovac, Dubravka, Vitezić, Dinko, Petrović, Oleg, Willheim, Ksenija, Jurjević, Ante, and Sindik, Nebojša
- Subjects
Epilepsija ,Trudnoća ,Antiepileptici ,Teratogenost - Abstract
Cilj rada je bio analizirati uporabu antiepileptičkih lijekova (AEL) u žena s epilepsijom te vrednovati specifičnosti trudnoće i epilepsije s mogućim štetnim učincima AEL na plod. Retrospektivna desetgodišnja studija (1.1.1993.-31.12.2002.) obuhvačala je 151 trudnicu s epilepsijom i 185 djece. U 111 trudnica primijenjeni su AEL, u 77& kao monoterapija. Najčešće primjenjivani AEL bili su karbamazepin (36.2%), valproat (29.3%) i fenobarbiton (24.1%). Specifični teratogeni učinci AEL nisu zabilježeni. Istraživanje je pokazalo najčešću uporabu AEL "starije generacije", a budući da nisu zabilježene veće malformacije potvrđen je njihov relativno mali potencijalni teratogeni rizik.
- Published
- 2005
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