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1. GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial

Author

Ziviani, Luigi, Malescio, Feliciana, Turrini, Irene, Lawlor, Rita, Romano, Annamaria, Nunziata, Mariagrazia, Armato, Salvatore, Mazzeo, Nicole, Carleo, Maria Aurora, Dell’Isola, Chiara, Pisapia, Raffaella, Pontarelli, Agostina, Olivani, Andrea, Grasselli, Sara, Laccabue, Diletta, Leoni, Maria Cristina, Paolillo, Franco, Mancini, Annalisa, Ruaro, Barbara, Confalonieri, Marco, Salton, Francesco, Mancarella, Giulia, Marocco, Raffaella, De Masi, Margherita, Belvisi, Valeria, Lamonica, Silvia, Cingolani, Antonella, Seguiti, Cristina, Brambilla, Paola, Ferraresi, Alice, Lupi, Matteo, Ludovisi, Serena, Renisi, Giulia, Massafra, Roberta, Pellicciotta, Martina, Armiento, Luciana, Vimercati, Stefania, Piacenza, Mariagrazia, Bonfanti, Paolo, Columpsi, Paola, Cazzaniga, Marina Elena, Rovelli, Cristina, Ceresini, Mariaelena, Previtali, Letizia, Trentini, Laura, Alcantarini, Chiara, Rugge, Walter, Biffi, Stefano, Poletti, Federica, Rostagno, Roberto, Moglia, Roberta, De Negri, Ferdinando, Fini, Elisabetta, Cangialosi, Alice, Bruno, Serena Rita, Rizzo, Marianna, Niglio, Mariangela, Stritto, Anna Dello, Matano, Alfredo, Petruzziello, Arnolfo, Valsecchi, Pietro, Pieri, Teresa, Altamura, Mauro, Calamo, Angela, Giannelli, Anna, Menolascina, Stefania, Di Bari, Silvia, Mauro, Vera, Aronica, Raissa, Segala, Daniela, Cultrera, Rosario, Sighinolfi, Laura, Abbott, Michelle, Gizzi, Andrea, Marascia, Federica Guida, Valenti, Giacomo, Feasi, Marcello, Bobbio, Nicoletta, Del Puente, Filippo, Nicosia, Alfredo, Frascà, Martina, Mazzoleni, Miriam, Garofalo, Nadia, Ammendola, Virginia, Grazioli, Fabiana, Napolitano, Federico, Vitelli, Alessandra, Marcellini, Valentina, Capone, Stefania, Fusco, Francesco M., Milleri, Stefano, Borrè, Silvio, Carbonara, Sergio, Lo Caputo, Sergio, Leone, Sebastiano, Gori, Giovanni, Maggi, Paolo, Cascio, Antonio, Lichtner, Miriam, Cauda, Roberto, Dal Zoppo, Sarah, Cossu, Maria V., Gori, Andrea, Roda, Silvia, Confalonieri, Paola, Bonora, Stefano, Missale, Gabriele, Codeluppi, Mauro, Mezzaroma, Ivano, Capici, Serena, Pontali, Emanuele, Libanore, Marco, Diani, Augusta, Lanini, Simone, Battella, Simone, Contino, Alessandra M., Piano Mortari, Eva, Genova, Francesco, Parente, Gessica, Dragonetti, Rosella, Colloca, Stefano, Visani, Luigi, Iannacone, Claudio, Carsetti, Rita, Folgori, Antonella, and Camerini, Roberto

Published
2023
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7. Platelet gel in cutaneous radiation dermatitis

Author

Iervolino, Vincenzo, Di Costanzo, Gaetano, Azzaro, Rosa, Diodato, Anna Maria, Di Macchia, Catia Addolorata, Di Meo, Tommaso, Petruzziello, Arnolfo, Loquercio, Giovanna, Muto, Paolo, Apice, Gaetano, and Cacciapuoti, Carmela

Published
2013
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18. Use of allogeneic platelet gel in the management of chemotherapy extravasation injuries: a case report

Author

Loquercio, Giovanna, Di Costanzo,Gaetano, Marcacci,Gianpaolo, Iervolino,Vincenzo, Mori,Stefano, Petruzziello,Arnolfo, Barra,Pasquale, and Cacciapuoti,Carmela

Subjects
OncoTargets and Therapy
Abstract

Gaetano Di Costanzo,1 Giovanna Loquercio,1 Gianpaolo Marcacci,2 Vincenzo Iervolino,1 Stefano Mori,3 Arnolfo Petruzziello,1 Pasquale Barra,1 Carmela Cacciapuoti1 1Transfusion Service, Department of Haematology, National Cancer Institute “G Pascale” Foundation, IRCCS, Naples, Italy; 2Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute “G Pascale” Foundation, IRCCS, Naples, Italy; 3Department of Surgery, Melanoma – Soft Tissues – Head andNeck – Skin Cancers, National Cancer Institute “G Pascale” Foundation, IRCCS, Naples, Italy Abstract: The allogeneic platelet (PLT) gel offers to be a valid supportive measure in the management of chemotherapy extravasation injuries. We report a case of a 58-year-old patient with multiple myeloma enrolled for high-dose chemotherapy and autologous stem cell transplantation. As pretransplant therapy, the patient received induction therapy with bortezomib, adriblastina, and desametazone. A port was inserted in the vein on the back of the hand. After three cycles, the patient reported rapid development of redness, pain, and necrotic tissue in the left hand, and a diagnosis of extravasation was addressed. The patient presented a raw area on the back of the hand caused by cytotoxic/chemotherapeutic drug leakage because of the malposition of venous access devices. Skin ulcer was debrided, and the wound was reconstructed with a combination of local random rotational flap and abdomen skin graft. Two weeks later, a 20% skin flap necrosis was observed. In the context of wound healing, topical plasma-rich PLT gel is able to accelerate the regeneration and repair of tissue, so it was set out to assess PLT gel efficacy in this case. The PLT gel was applied topically once every 5 days, for a duration of 60days on average. There were no adverse reactions observed during the topical therapy. Complete wound healing was observed after 12 PLT-rich plasma applications. No ulcer recurrence was noted in the patient during the follow-up period of 2–19months. Keywords: growth factors, platelet gel, chemotherapy, management, extravasation

Published
2015

21. Distribution Pattern of Hepatitis C Virus Genotypes and Correlation with Viral Load and Risk Factors in Chronic Positive Patients

Author

Petruzziello, Arnolfo, primary, Coppola, Nicola, additional, Loquercio, Giovanna, additional, Marigliano, Samantha, additional, Giordano, Margherita, additional, Azzaro, Rosa, additional, Diodato, Anna Maria, additional, Iervolino, Vincenzo, additional, Di Costanzo, Gaetano, additional, Di Macchia, Catia Addolorata, additional, Di Meo, Tommaso, additional, Paradiso, Laurenza, additional, Ferro, Rosario, additional, Giuliano, Pasquale, additional, Russo, Ferdinando, additional, Pasquale, Giuseppe, additional, and Cacciapuoti, Carmela, additional

Published
2014
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22. HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient

Author

Coppola, Nicola, primary, Loquercio, Giovanna, additional, Tonziello, Gilda, additional, Azzaro, Rosa, additional, Pisaturo, Mariantonietta, additional, Di Costanzo, Gaetano, additional, Starace, Mario, additional, Pasquale, Giuseppe, additional, Cacciapuoti, Carmela, additional, and Petruzziello, Arnolfo, additional

Published
2013
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23. Age and Gender Distribution of Hepatitis C Virus Genotypes in the Metropolitan Area of Naples

Author

Petruzziello, Arnolfo, primary, Coppola, Nicola, additional, Diodato, Anna Maria, additional, Iervolino, Vincenzo, additional, Azzaro, Rosa, additional, Di Costanzo, Gaetano, additional, Di Macchia, Catia Addolorata, additional, Di Meo, Tommaso, additional, Loquercio, Giovanna, additional, Pasquale, Giuseppe, additional, and Cacciapuoti, Carmela, additional

Published
2013
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24. Platelet gel in cutaneous radiation dermatitis

Author

Iervolino, Vincenzo, primary, Di Costanzo, Gaetano, additional, Azzaro, Rosa, additional, Diodato, Anna Maria, additional, Di Macchia, Catia Addolorata, additional, Di Meo, Tommaso, additional, Petruzziello, Arnolfo, additional, Loquercio, Giovanna, additional, Muto, Paolo, additional, Apice, Gaetano, additional, and Cacciapuoti, Carmela, additional

Published
2012
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25. GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial (COVITAR)

Author

Capone, Stefania, Fusco, Francesco M., Milleri, Stefano, Borrè, Silvio, Carbonara, Sergio, Lo Caputo, Sergio, Leone, Sebastiano, Gori, Giovanni, Maggi, Paolo, Cascio, Antonio, Lichtner, Miriam, Cauda, Roberto, Zoppo, Sarah Dal, Cossu, Maria V., Gori, Andrea, Roda, Silvia, Confalonieri, Paola, Bonora, Stefano, Missale, Gabriele, Codeluppi, Mauro, Mezzaroma, Ivano, Capici, Serena, Pontali, Emanuele, Libanore, Marco, Diani, Augusta, Lanini, Simone, Battella, Simone, Contino, Alessandra M., Mortari, Eva Piano, Genova, Francesco, Parente, Gessica, Dragonetti, Rosella, Colloca, Stefano, Visani, Luigi, Iannacone, Claudio, Carsetti, Rita, Folgori, Antonella, Camerini, Roberto, Ziviani, Luigi, Malescio, Feliciana, Turrini, Irene, Lawlor, Rita, Romano, Annamaria, Nunziata, Mariagrazia, Armato, Salvatore, Mazzeo, Nicole, Carleo, Maria Aurora, Dell’Isola, Chiara, Pisapia, Raffaella, Pontarelli, Agostina, Olivani, Andrea, Grasselli, Sara, Laccabue, Diletta, Leoni, Maria Cristina, Paolillo, Franco, Mancini, Annalisa, Ruaro, Barbara, Confalonieri, Marco, Salton, Francesco, Mancarella, Giulia, Marocco, Raffaella, De Masi, Margherita, Belvisi, Valeria, Lamonica, Silvia, Cingolani, Antonella, Seguiti, Cristina, Brambilla, Paola, Ferraresi, Alice, Lupi, Matteo, Ludovisi, Serena, Renisi, Giulia, Massafra, Roberta, Pellicciotta, Martina, Armiento, Luciana, Vimercati, Stefania, Piacenza, Mariagrazia, Bonfanti, Paolo, Columpsi, Paola, Cazzaniga, Marina Elena, Rovelli, Cristina, Ceresini, Mariaelena, Previtali, Letizia, Trentini, Laura, Alcantarini, Chiara, Rugge, Walter, Biffi, Stefano, Poletti, Federica, Rostagno, Roberto, Moglia, Roberta, De Negri, Ferdinando, Fini, Elisabetta, Cangialosi, Alice, Bruno, Serena Rita, Rizzo, Marianna, Niglio, Mariangela, Stritto, Anna Dello, Matano, Alfredo, Petruzziello, Arnolfo, Valsecchi, Pietro, Pieri, Teresa, Altamura, Mauro, Calamo, Angela, Giannelli, Anna, Menolascina, Stefania, Di Bari, Silvia, Mauro, Vera, Aronica, Raissa, Segala, Daniela, Cultrera, Rosario, Sighinolfi, Laura, Abbott, Michelle, Gizzi, Andrea, Marascia, Federica Guida, Valenti, Giacomo, Feasi, Marcello, Bobbio, Nicoletta, Del Puente, Filippo, Nicosia, Alfredo, Frascà, Martina, Mazzoleni, Miriam, Garofalo, Nadia, Ammendola, Virginia, Grazioli, Fabiana, Napolitano, Federico, Vitelli, Alessandra, and Marcellini, Valentina

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and heterologous immunization approaches implemented worldwide for booster doses call for diversified vaccine portfolios. GRAd-COV2 is a gorilla adenovirus-based COVID-19 vaccine candidate encoding prefusion-stabilized spike. The safety and immunogenicity of GRAd-COV2 is evaluated in a dose- and regimen-finding phase 2 trial (ClinicalTrials.gov: NCT04791423) whereby 917 eligible participants are randomized to receive a single intramuscular GRAd-COV2 administration followed by placebo, or two vaccine injections, or two doses of placebo, spaced over 3 weeks. Here, we report that GRAd-COV2 is well tolerated and induces robust immune responses after a single immunization; a second administration increases binding and neutralizing antibody titers. Potent, variant of concern (VOC) cross-reactive spike-specific T cell response peaks after the first dose and is characterized by high frequencies of CD8s. T cells maintain immediate effector functions and high proliferative potential over time. Thus, GRAd vector is a valuable platform for genetic vaccine development, especially when robust CD8 response is needed.

Published
2023
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26. Use of allogeneic platelet gel in the management of chemotherapy extravasation injuries: a case report.

Author

Di Costanzo, Gaetano, Loquercio, Giovanna, Marcacci, Gianpaolo, Iervolino, Vincenzo, Mori, Stefano, Petruzziello, Arnolfo, Barra, Pasquale, and Cacciapuoti, Carmela

Subjects
EXTRAVASATION, CANCER chemotherapy, STEM cell transplantation, BORTEZOMIB, SKIN grafting
Abstract

The allogeneic platelet (PLT) gel offers to be a valid supportive measure in the management of chemotherapy extravasation injuries. We report a case of a 58-year-old patient with multiple myeloma enrolled for high-dose chemotherapy and autologous stem cell transplantation. As pretransplant therapy, the patient received induction therapy with bortezomib, adriblastina, and desametazone. A port was inserted in the vein on the back of the hand. After three cycles, the patient reported rapid development of redness, pain, and necrotic tissue in the left hand, and a diagnosis of extravasation was addressed. The patient presented a raw area on the back of the hand caused by cytotoxic/chemotherapeutic drug leakage because of the malposition of venous access devices. Skin ulcer was debrided, and the wound was reconstructed with a combination of local random rotational flap and abdomen skin graft. Two weeks later, a 20% skin flap necrosis was observed. In the context of wound healing, topical plasma-rich PLT gel is able to accelerate the regeneration and repair of tissue, so it was set out to assess PLT gel efficacy in this case. The PLT gel was applied topically once every 5 days, for a duration of 60 days on average. There were no adverse reactions observed during the topical therapy. Complete wound healing was observed after 12 PLT-rich plasma applications. No ulcer recurrence was noted in the patient during the follow-up period of 2–19 months. [ABSTRACT FROM AUTHOR]

Published
2015
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27. Analytical performance evaluation of Lumipulse® <scp>SARS‐CoV</scp> ‐2 antigen assay in 392 asymptomatic patients

Author

Arnolfo Petruzziello, Rocco Sabatino, Livia Anna Catapane, Carmela De Falco, Antonella Petti, Elena Tripaldelli, Giovanna Loquercio, Angela Annecchiarico, Angela Salzillo, Eugenio Caradonna, Paolo Maggi, Petruzziello, Arnolfo, Sabatino, Rocco, Catapane, Livia Anna, De Falco, Carmela, Petti, Antonella, Tripaldelli, Elena, Loquercio, Giovanna, Annecchiarico, Angela, Salzillo, Angela, Caradonna, Eugenio, and Maggi, Paolo

Subjects
SARS-CoV-2 antigen, Microbiology (medical), Medical Laboratory Technology, comparison, Biochemistry (medical), Clinical Biochemistry, RT-PCR, Public Health, Environmental and Occupational Health, COVID-19, asymptomatic, Immunology and Allergy, Hematology
Abstract

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the current public health care challenges. The main strategy adopted to prevent the spread of infection is the rapid identification of COVID-19-positive subjects. The aim of this study was to compare the performance of Lumipulse® antigen immunoassay with the real-time RT-PCR, the gold standard for the diagnosis of SARS-CoV-2 infection, in a strictly selected asymptomatic population. Materials and methods: A total of 392 consecutive oro-nasopharyngeal swabs were collected from patients with no symptoms related to COVID-19 at the Emergency Department of AORN Sant'Anna e San Sebastiano, Caserta, Italy to evaluate the analytical performance of Lumipulse® SARS-CoV-2 antigen compared to qualitative real-time RT-PCR in asymptomatic patients. Results: Lumipulse® SARS-CoV-2 antigen assay shows an overall agreement rate of 97% with a sensitivity of 96% and a specificity of 98%, with a PPV and NPV of 97%. The sensitivity varies according to the cycle threshold (Ct )-value reaching 100% and 86% with 15

Published
2023

28. Hepatitis C virus (HCV) micro-elimination in the hospital setting: The results of the HCV Caserta hospital project

Author

Vincenzo Messina, Mariantonietta Pisaturo, Loredana Alessio, Antonio Russo, Elena Tripaldelli, Arnolfo Petruzziello, Angela Annecchiarico, Maria Rosaria Romano, Paolo Maggi, Nicola Coppola, Messina, Vincenzo, Pisaturo, Mariantonietta, Alessio, Loredana, Russo, Antonio, Tripaldelli, Elena, Petruzziello, Arnolfo, Annecchiarico, Angela, Romano, Maria Rosaria, Maggi, Paolo, and Coppola, Nicola

Subjects
Adult, Antiviral Agent, Hepaciviru, Case-finding, Public Health, Environmental and Occupational Health, Micro-elimination, General Medicine, Hepacivirus, Hepatitis C, Chronic, Antiviral Agents, Hepatitis C, Hospitals, HCV infection, Hospital, Prospective Studie, Infectious Diseases, Linkage-to-care, Humans, RNA, Prospective Studies, DAA, Human
Abstract

Background: In the present study we evaluated the efficacy of an innovative model of HCV micro-elimination in a hospital setting in an area of high HCV prevalence.Patients and metods: Between January and December 2019, a prospective, interventional study for a program of HCV case-finding and linkage-to-care was performed in S. Anna and S. Sebastiano hospital of Caserta, in Campania, a region in southern Italy. All adult patients who were admitted to the Caserta hospital in the study period and resulted positive for anti-HCV were included in the study. The outcomes evaluated were the number of subjects resulting HCV-RNA-positive, those linked-to-care and treated with a DAA and the subjects whose anti-HCV-status was unknown.Results: In the study period, 14,396 subjects, admitted to the hospital for different reasons, were tested for anti-HCV: 529 (3.7%) subjects resulted positive for anti-HCV. Of the 529 anti-HCV-positive subjects, 10 died during hospitalization and 243 were already treated with a DAA. The remaining 276 subjects were contacted and agreed to be evaluated. Of these 276 subjects, 68 patients resulted HCV- RNA-negative and 194 HCV-RNA-positive and 180 of these were treated with a DAA according to the international guidelines.Discussion: A simple, rapid, inexpensive model of HCV micro-elimination in the hospital setting allowed us to find anti-HCV-positive subjects with unknown anti-HCV status or not linked to a clinical center. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. CC_BY_NC_ND_4.0

Published
2022

30. Autologous Platelet Gel Improves Bone Reconstruction of Large Defects in Patients with Bone Giant Cell Tumors.

Author

Loquercio G, DI Costanzo G, Fazioli F, Gallo M, DE Chiara A, Iervolino V, Azzaro R, Petruzziello A, Mattiello A, and Cacciapuoti C

Subjects
Adolescent, Adult, Aged, Bone Neoplasms diagnostic imaging, Curettage, Female, Follow-Up Studies, Giant Cell Tumor of Bone diagnostic imaging, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Tomography, X-Ray Computed, Treatment Outcome, Young Adult, Blood Transfusion, Autologous, Bone Neoplasms pathology, Bone Neoplasms therapy, Giant Cell Tumor of Bone pathology, Giant Cell Tumor of Bone therapy, Platelet Transfusion methods, Plastic Surgery Procedures
Abstract

Background/aim: Giant cell tumors are mostly benign but locally aggressive tumors. The excision of bone tumors can result in large defects, therefore bone reconstruction is still one the most demanding procedures in orthopedic surgery. Our study addresses the opportunity for improving surgical outcome by employing β-tricalcium phosphate (β-TCP) with platelet-rich plasma (PRP) at the surgical site., Patients and Methods: We included 16 patients with giant cell tumors. After adjuvant therapy, the cavity was reconstructed with β-TCP, bone graft material (ActifuserR Granules Baxter) and platelet gel application., Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients with giant cell tumors treated with curettage., Conclusion: Use of platelet gel as an adjuvant significantly reduces the time required for bone healing following intralesional treatment of benign giant cell tumors, and achieves good functional results without promoting local recurrence., (Copyright © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

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