Search

Your search keyword '"Petruzziello, R."' showing total 12 results
Start Over Author "Petruzziello, R."
12 results on '"Petruzziello, R."'

4. Virus-cell early interactions

Author

Orsi, Nicola, Conte, Maria Pia, Conti, Cinzia, Goldoni, Paola, Mastromarino, P, Pietropaolo, Valeria Antonietta, Seganti, Lucilla, Sinibaldi, Laura, Cattani, L, Di Taranto, C, Longhi, Catia, Marchetti, M, Petruzziello, R, Tsiang, H, Li, J, Frey, Tk, Nicoletti, M, Degener, Anna Marta, and Nicoletti, R.

Published
1995

5. Inhibition of Sindbis virus replication by cyclopentenone prostaglandins: a cell-mediated event associated with heat-shock protein synthesis

Author

Mastromarino, P, Conti, C, Petruzziello, R, De Marco, A, Pica, F, and Santoro, Mg

Subjects
Electrophoresis, Prostaglandins A, Polyacrylamide Gel, Virus Replication, Animals, Immunoblotting, Viral Proteins, Viral Plaque Assay, Electrophoresis, Polyacrylamide Gel, Sindbis Virus, Antiviral Agents, RNA, Viral, DNA, Viral, Dactinomycin, Vero Cells, Uridine, Heat-Shock Proteins, DNA, Settore MED/07 - Microbiologia e Microbiologia Clinica, RNA, Viral
Published
1993

10. Antiviral activity of natural and semisynthetic polysaccharides on the early steps of rubella virus infection.

Author

Mastromarino, P, Petruzziello, R, Macchia, S, Rieti, S, Nicoletti, R, and Orsi, N

Abstract

The natural and semisynthetic carbohydrates scleroglucan, locust bean gum, tamarind gum (glyloid) and its three sulphate derivatives (GP4311, GP4327 and GP4324), glycogen and its two sulphate derivatives (GP4427 and GP4435), alginic acid and dextran sulphate, were investigated for their inhibitory effect on rubella virus (RV) infection of Vero cells. The neutral polymer scleroglucan and two highly negatively charged compounds, glyloid sulphate 4324 and dextran sulphate, had the highest inhibitory effect on RV antigen synthesis. The antiviral properties of active molecules appears to be dependent on the shape of the macromolecule and/or on the electric charge, while saccharide units play a minor role. The results indicated that polysaccharides blocked a step in virus replication subsequent to virus attachment, such as internalization and/or uncoating. Confirmation that the inhibitory activity of the compounds was directed at the early steps of RV multiplication, was that none of the polysaccharides had any effect on infection initiated by transfection of cells with RVRNA. [ABSTRACT FROM AUTHOR]

Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results