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8. THERMAL LOAD CONTROL IN HIGH-TEMPERATURE HEAT PUMPS : A COMPARATIVE STUDY

Author

Pettinari, M., Frate, G. F., Ferrari, L., Yücel, F. C., Tran, A. P., Stathopoulos, P., Kyprianidis, Konstantinos, Pettinari, M., Frate, G. F., Ferrari, L., Yücel, F. C., Tran, A. P., Stathopoulos, P., and Kyprianidis, Konstantinos

Abstract

High-temperature heat pumps (HTHPs) are becoming increasingly relevant in the industry as they represent a promising solution for decarbonising industrial heat. These technologies can enable the electrification of industrial processes by exploiting electricity from renewables to provide process heat at temperatures above 250 °C, as in the case of emerging Brayton-based HTHPs. To succeed in this purpose, HTHPs must also ensure operational flexibility, which entails the ability to operate safely under varying loads and promptly respond to fluctuations in demand, while maintaining high efficiencies. Moreover, the ability to provide large flexible electric loads to transmission system operators, has the potential to unlock innovative business cases and further promote the use of these systems. Common control strategies for achieving this, include employing bypass mechanisms, fluid inventory control, and adjusting turbomachinery rotational speeds. Despite their variety, the simultaneous use of such control strategies is often limited as they may lead to significantly different system behaviours, both in terms of transient and steady performance. In this paper, rotational speed and fluid inventory control are examined from a transient perspective to maintain the desired sink temperature while regulating the thermal load of the system. Results indicate that rotational speed control leads to negligible sink temperature residuals, while fluid inventory control better preserves the HTHP performances for varying temperature glides.

Published
2024
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13. Contributors

Author

Abdelaal, Ali Samy, primary, Adam, David, additional, Altaii, Hiyam Adil, additional, Bai, Zhong-Hu, additional, Basu, Upasana, additional, Bhattacharjee, Gargi, additional, Bolívar, Jorge, additional, Borkowski, Olivier, additional, Cai, Siqin, additional, Carbonell, Pablo, additional, Coutte, François, additional, Da Costa, Matthieu, additional, de Diego Puente, Teresa, additional, Dhali, Debarun, additional, Díaz, Manuel Cánovas, additional, Diehl, Christoph, additional, Eckert, Carrie A., additional, Egoburo, Diego E., additional, El-Naggar, Noura El-Ahmady, additional, Enguita, Francisco J., additional, Freed, Emily F., additional, Gallego-Jara, Julia, additional, Gohil, Nisarg, additional, Hamouda, Ragaa A., additional, Jacques, Philippe, additional, Pettinari, M. Julia, additional, Jutur, Pannaga P., additional, Kareya, Mukul S., additional, Leclère, Valérie, additional, Leitão, Ana Lúcia, additional, Li, Ye, additional, Liang, Liya, additional, Liu, Rongming, additional, Liu, Xiu-Xia, additional, Ma, Zengxin, additional, Madzak, Catherine, additional, Martínez, Rosa Alba Sola, additional, Mitsui, Ryosuke, additional, Mo, Xuhua, additional, Moritz, Charles, additional, Mozejko-Ciesielska, Justyna, additional, Nesamma, Asha A., additional, Paliwal, Chetan, additional, Pandi, Amir, additional, Paul, Subha Sankar, additional, Ramzi, Ahmad Bazli, additional, Schada von Borzyskowski, Lennart, additional, Singh, Rabinder, additional, Singh, Vijai, additional, Stettner, Sean, additional, Sun, Yuman, additional, Sundaram, Srividhya, additional, Terol, Gema Lozano, additional, Trabelsi, Heykel, additional, Valle, Antonio, additional, Wang, Mengying, additional, Xiao, Han, additional, Xing, Xinhui, additional, Yamada, Ryosuke, additional, Yang, Song, additional, Yaseen, Yazen, additional, Yazdani, Syed Shams, additional, Yu, Guihong, additional, Zhang, Changtai, additional, and Zhang, Hui, additional

Published
2021
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16. Pleiotropic Effects of PhaR Regulator in Bradyrhizobium diazoefficiens Microaerobic Metabolism.

Author

Quelas, Juan I., Cabrera, Juan J., Díaz-Peña, Rocío, Sánchez-Schneider, Lucía, Jiménez-Leiva, Andrea, Tortosa, Germán, Delgado, María J., Pettinari, M. Julia, Lodeiro, Aníbal R., del Val, Coral, and Mesa, Socorro

Subjects
MUTANT proteins, TRANSCRIPTION factors, ROOT-tubercles, METABOLISM, BRADYRHIZOBIUM, DNA-protein interactions, RHIZOBIUM
Abstract

Bradyrhizobium diazoefficiens can live inside soybean root nodules and in free-living conditions. In both states, when oxygen levels decrease, cells adjust their protein pools by gene transcription modulation. PhaR is a transcription factor involved in polyhydroxyalkanoate (PHA) metabolism but also plays a role in the microaerobic network of this bacterium. To deeply uncover the function of PhaR, we applied a multipronged approach, including the expression profile of a phaR mutant at the transcriptional and protein levels under microaerobic conditions, and the identification of direct targets and of proteins associated with PHA granules. Our results confirmed a pleiotropic function of PhaR, affecting several phenotypes, in addition to PHA cycle control. These include growth deficiency, regulation of carbon and nitrogen allocation, and bacterial motility. Interestingly, PhaR may also modulate the microoxic-responsive regulatory network by activating the expression of fixK2 and repressing nifA, both encoding two transcription factors relevant for microaerobic regulation. At the molecular level, two PhaR-binding motifs were predicted and direct control mediated by PhaR determined by protein-interaction assays revealed seven new direct targets for PhaR. Finally, among the proteins associated with PHA granules, we found PhaR, phasins, and other proteins, confirming a dual function of PhaR in microoxia. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Malperfusion Syndrome in Patients with Acute Type A Aortic Dissection: Incidence and Mortality Rates after Surgical Repair.

Author

Dell, A. A., Wisniewski, K., Onorati, F., Demal, T.J., Peterss, S., Fiore, A., Perrotti, A., Nappi, F., Pinto, A.G., Pol, M., Mazzaro, E., Vendramin, I., Ferrante, L., Quintana, E., Gerelli, S., Acharya, M., Field, M., Pettinari, M., Stefano, R., and Juvonen, T.

Subjects
AORTIC dissection, DEATH rate, DISSECTION, SYNDROMES, HOSPITAL mortality
Abstract

This article discusses the incidence and mortality rates of malperfusion syndrome in patients with acute Type A aortic dissection after surgical repair. The study, conducted across 18 European centers, included 3,902 patients. It found that 45.62% of patients presented with signs of preoperative malperfusion, with the most common type being cerebral malperfusion. The study also showed that rates of in-hospital mortality increased with the severity of malperfusion. The authors conclude that different levels of the Penn classification can be used as valid predictors of mortality. [Extracted from the article]

Published
2024
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18. Outcome of Patients undergoing Surgery for Acute Type A Aortic Dissection after Cardiopulmonary Resuscitation.

Author

Al-Hafez, B., Demal, T.J., Detter, C., Mariscalco, G., Gatti, G., Mazzaro, E., Acharya, M., Peterss, S., Buech, J., Herve, A., Folliguet, T., Pettinari, M., Dell, A. A., Wisniewski, K., Pol, M., Piani, D., Jormalainen, M., Rodriguez, L. J., Pinto, AG., and Quintana, E.

Subjects
AORTIC dissection, CARDIOPULMONARY resuscitation, DISSECTION, MULTIPLE regression analysis, SURGERY
Abstract

This article examines the outcomes of patients with acute type A aortic dissection (ATAD) who underwent surgery after receiving preoperative cardiopulmonary resuscitation (CPR). The study analyzed data from the European registry of type A aortic dissection (ERTAAD) and included 2,266 ATAD patients from 19 European centers. The results showed that patients who required CPR before surgery had higher rates of postoperative complications, including stroke, heart failure, and the need for dialysis. They also had a higher 30-day mortality rate. However, when additional risk factors such as low ejection fraction, advanced age, and myocardial ischemia were present, the analysis did not indicate a significant increase in mortality, suggesting that surgery may still be a viable option for these patients. [Extracted from the article]

Published
2024
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19. Towards an Integrated Approach to Wildfire Risk Assessment: When, Where, What and How May the Landscapes Burn

Author

Chuvieco, Emilio, primary, Yebra, Marta, additional, Martino, Simone, additional, Thonicke, Kirsten, additional, Gómez-Giménez, Marta, additional, San-Miguel, Jesus, additional, Oom, Duarte, additional, Velea, Ramona, additional, Mouillot, Florent, additional, Molina, Juan R., additional, Miranda, Ana I., additional, Lopes, Diogo, additional, Salis, Michele, additional, Bugaric, Marin, additional, Sofiev, Mikhail, additional, Kadantsev, Evgeny, additional, Gitas, Ioannis Z., additional, Stavrakoudis, Dimitris, additional, Eftychidis, George, additional, Bar-Massada, Avi, additional, Neidermeier, Alex, additional, Pampanoni, Valerio, additional, Pettinari, M. Lucrecia, additional, Arrogante-Funes, Fatima, additional, Ochoa, Clara, additional, Moreira, Bruno, additional, and Viegas, Domingos, additional

Published
2023
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20. Towards an Integrated Approach to Wildfire Risk Assessment: When, Where, What and How May the Landscapes Burn

Author

European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Chuvieco, Emilio, Yebra, Marta, Martino, Simone, Thonicke, Kirsten, Gómez-Giménez, Marta, San-Miguel, Jesus, Oom, Duarte, Velea, Ramona, Mouillot, Florent, Molina, Juan R., Miranda, Ana I., Lopes, Diogo, Salis, Michele, Bugaric, Marin, Sofiev, Mikhail, Kadantsev, Evgeny, Gitas, Ioannis Z., Stavrakoudis, Dimitris, Eftychidis, George, Bar-Massada, Avi, Neidermeier, Alex, Pampanoni, Valerio, Pettinari, M. Lucrecia, Arrogante-Funes, Fatima, Ochoa, Clara, Moreira, Bruno, Viegas, Domingo, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Chuvieco, Emilio, Yebra, Marta, Martino, Simone, Thonicke, Kirsten, Gómez-Giménez, Marta, San-Miguel, Jesus, Oom, Duarte, Velea, Ramona, Mouillot, Florent, Molina, Juan R., Miranda, Ana I., Lopes, Diogo, Salis, Michele, Bugaric, Marin, Sofiev, Mikhail, Kadantsev, Evgeny, Gitas, Ioannis Z., Stavrakoudis, Dimitris, Eftychidis, George, Bar-Massada, Avi, Neidermeier, Alex, Pampanoni, Valerio, Pettinari, M. Lucrecia, Arrogante-Funes, Fatima, Ochoa, Clara, Moreira, Bruno, and Viegas, Domingo

Abstract

This paper presents a review of concepts related to wildfire risk assessment, including the determination of fire ignition and propagation (fire danger), the extent to which fire may spatially overlap with valued assets (exposure), and the potential losses and resilience to those losses (vulnerability). This is followed by a brief discussion of how these concepts can be integrated and connected to mitigation and adaptation efforts. We then review operational fire risk systems in place in various parts of the world. Finally, we propose an integrated fire risk system being developed under the FirEUrisk European project, as an example of how the different risk components (including danger, exposure and vulnerability) can be generated and combined into synthetic risk indices to provide a more comprehensive wildfire risk assessment, but also to consider where and on what variables reduction efforts should be stressed and to envisage policies to be better adapted to future fire regimes. Climate and socio-economic changes entail that wildfires are becoming even more a critical environmental hazard; extreme fires are observed in many areas of the world that regularly experience fire, yet fire activity is also increasing in areas where wildfires were previously rare. To mitigate the negative impacts of fire, those responsible for managing risk must leverage the information available through the risk assessment process, along with an improved understanding on how the various components of risk can be targeted to improve and optimize the many strategies for mitigation and adaptation to an increasing fire risk.

Published
2023

23. Predictor Analysis for Acute Type A Aortic Dissection in Small Aortic Diameters

Author

Demal, T. J., additional, Detter, C., additional, von Kodolitsch, Y., additional, Mariscalco, G., additional, Gatti, G., additional, Peterss, S., additional, Büch, J., additional, Onorati, F., additional, Perrotti, A., additional, Fiore, A., additional, Pettinari, M., additional, Dell'aquila, A. M., additional, Pol, M., additional, Field, M., additional, Vendramin, I., additional, Rinaldi, M., additional, Lega, J. R., additional, Juvonen, T., additional, Quintana, E., additional, Pinto, A. G., additional, Nappi, F., additional, Di Perna, D., additional, Reichenspurner, H., additional, Biancari, F., additional, and Conradi, L., additional

Published
2023
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24. Outcome in Night- versus Daytime Surgery for Acute Type A Aortic Dissection

Author

Knochenhauer, T., additional, Demal, T. J., additional, Detter, C., additional, Nappi, F., additional, Di Perna, D., additional, Pol, M., additional, Juvonen, T., additional, Mariscalco, G., additional, Gatti, G., additional, Peterss, S., additional, Perrotti, A., additional, Fiore, A., additional, Pettinari, M., additional, Dell'aquila, A. M., additional, Vendramin, I., additional, Rinaldi, M., additional, Quintana, E., additional, Pinto, A. G., additional, Field, M., additional, Reichenspurner, H., additional, Biancari, F., additional, and Conradi, L., additional

Published
2023
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26. Additional file 2 of Guanine crystal formation by bacteria

Author

Pavan, María Elisa, Movilla, Federico, Pavan, Esteban E., Di Salvo, Florencia, López, Nancy I., and Pettinari, M. Julia

Abstract

Additional file 2: Figure S3. ESI–MS experiment for guanine produced by 34mel. Figure S4. ESI–MS and MS/MS experiments for commercial guanine. Figure S5. 1H-NMR characterization of 34mel crystals. Figure S6. UV–vis spectra for commercial and 34mel guanine in acid solution. Additional data 1. Elemental analysis of crystals purified from 34mel.

Published
2023
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27. Additional file 3 of Guanine crystal formation by bacteria

Author

Pavan, María Elisa, Movilla, Federico, Pavan, Esteban E., Di Salvo, Florencia, López, Nancy I., and Pettinari, M. Julia

Abstract

Additional file 3: Additional methods 1. Methods used for the synthesis of the guanine crystalline phases from commercial guanine. Figure S7. X-ray diffraction studies of different crystal forms of guanine. Figure S8. Crystalline material obtained as result of crystallization experiments of commercial guanine with or without the addition of homogentisate melanin synthesized by 34mel at different pH conditions. Figure S9. Powder X-ray diffraction experiments of the crystalline material obtained under different crystallization conditions. Additional methods 2. Single crystal X-ray diffraction (XRD) of guaninium chloride dihydrate-melanin. Figure S10. Structure of guaninium chloride dihydrate crystallized in presence of melanin produced by the 34mel determined by single crystal X-ray diffraction. Table S1. Crystal data and structure refinement for guaninium chloride dihydrate crystallized in presence of melanin produced by 34mel. Table S2. Comparative analysis of different guaninium chloride dihydrate single crystal X-ray diffraction data.

Published
2023
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28. Additional file 1 of Guanine crystal formation by bacteria

Author

Pavan, María Elisa, Movilla, Federico, Pavan, Esteban E., Di Salvo, Florencia, López, Nancy I., and Pettinari, M. Julia

Abstract

Additional file 1: Figure S1. Crystalline aggregates in colonies from a month-old plate of A. salmonicida subsp. pectinolytica 34mel. Figure S2. Size distribution of the base of the prismatic crystals formed by 34mel grown in different conditions and by A. media.

Published
2023
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29. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Heuts, S, Mariani, S, van Bussel BCT, Boeken, U, Samalavicius, R, Bounader, K, Hou, X, Bunge, Jjh, Sriranjan, K, Wiedemann, D, Saeed, D, Pozzi, M, Loforte, Antonino, Salazar, L, Meyns, B, Mazzeffi, Ma, Matteucci, S, Sponga, S, Sorokin, V, Russo, C, Formica, F, Sakiyalak, P, Fiore, A, Camboni, D, Raffa, Gm, Diaz, R, Wang, Iw, Jung, Js, Belohlavek, J, Pellegrino, V, Bianchi, G, Pettinari, M, Barbone, A, Garcia, Jp, Shekar, K, Whitman, G, Lorusso, R, PELS-1, Investigators., Cardiology, and Intensive Care

Subjects
Pulmonary and Respiratory Medicine, SDG 3 - Good Health and Well-being, Surgery, Cardiology and Cardiovascular Medicine
Abstract

Background: Obesity is an important health problem in cardiac surgery and among patients requiring postcardiotomy venoarterial extracorporeal membrane oxygenation (V-A ECMO). Still, whether these patients are at risk for unfavorable outcomes after postcardiotomy V-A ECMO remains unclear. The current study evaluated the association between body mass index (BMI) and in-hospital outcomes in this setting. Methods: The Post-cardiotomy Extracorporeal Life Support (PELS-1) study is an international, multicenter study. Patients requiring postcardiotomy V-A ECMO in 36 centers from 16 countries between 2000 and 2020 were included. Patients were divided in 6 BMI categories (underweight, normal weight, overweight, class I, class II, and class III obesity) according to international recommendations. Primary outcome was in-hospital mortality, and secondary outcomes included major adverse events. Mixed logistic regression models were applied to evaluate associations between BMI and mortality. Results: The study cohort included 2046 patients (median age, 65 years; 838 women [41.0%]). In-hospital mortality was 60.3%, without statistically significant differences among BMI classes for in-hospital mortality (P = .225) or major adverse events (P = .126). The crude association between BMI and in-hospital mortality was not statistically significant after adjustment for comorbidities and intraoperative variables (class I: odds ratio [OR], 1.21; 95% CI, 0.88-1.65; class II: OR, 1.45; 95% CI, 0.86-2.45; class III: OR, 1.43; 95% CI, 0.62-3.33), which was confirmed in multiple sensitivity analyses. Conclusions: BMI is not associated to in-hospital outcomes after adjustment for confounders in patients undergoing postcardiotomy V-A ECMO. Therefore, BMI itself should not be incorporated in the risk stratification for postcardiotomy V-A ECMO.

Published
2023

30. Heterogeneity in Clinical Practices for Post-Cardiotomy Extracorporeal Life Support: a Pilot Survey from the PELS-1 Multicenter Study

Author

Mariani, S, Bari, G, Ravaux, Jm, van Bussel BCT, De Piero ME, Schaefer, Ak, Jawad, K, Pozzi, M, Loforte, Antonino, Kalampokas, N, Jankuviene, A, Flecher, E, Hou, X, Bunge, Jjh, Sriranjan, K, Salazar, L, Meyns, B, Mazzeffi, Ma, Matteucci, S, Sponga, S, Ramanathan, K, Costetti, A, Formica, F, Sakiyalak, P, Fiore, A, Schmid, C, Raffa, Gm, Castillo, R, Wang, Iw, Jung, Js, Grus, T, Pellegrino, V, Bianchi, G, Pettinari, M, Barbone, A, Garcia, Jp, Kowalewski, M, Shekar, K, Whitman, G, and Roberto Lorusso1, the PELS-1 Investigators.

Published
2023

31. On-Support and Post-Weaning Mortality in Post-Cardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, S, Schaefer, Ak, van Bussel BCT, Di Mauro, M, Conci, L, Szalkiewicz, P, De Piero ME, Heuts, S, Ravaux, J, van der Horst ICC, Saeed, D, Pozzi, M, Loforte, Antonino, Boeken, U, Samalavicius, R, Bounader, K, Hou, X, Bunge, Jjh, Buscher, H, Salazar, L, Meyns, B, Herr, D, Matteucci, S, Sponga, S, Maclaren, G, Russo, C, Formica, F, Sakiyalak, P, Fiore, A, Camboni, D, Raffa, Gm, Diaz, R, Wang, Iw, Jung, Js, Belohlavek, J, Pellegrino, V, Bianchi, G, Pettinari, M, Barbone, A, Garcia, Jp, Whitman, G, Shekar, K, Wiedemann, D, Lorusso, R, and PELS-1, Investigators.

Published
2023

33. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults: The PELS-1 Multicenter Cohort Study

Author

Mariani, S, Heuts, S, van Bussel BCT, Di Mauro, M, Wiedemann, D, Saeed, D, Pozzi, M, Loforte, Antonino, Boeken, U, Samalavicius, R, Bounader, K, Hou, X, Bunge, Jjh, Buscher, H, Salazar, L, Meyns, B, Herr, D, Matteucci, Mls, Sponga, S, Maclaren, G, Russo, C, Formica, F, Sakiyalak, P, Fiore, A, Camboni, D, Raffa, Gm, Diaz, R, Wang, Iw, Jung, Js, Belohlavek, J, Pellegrino, V, Bianchi, G, Pettinari, M, Barbone, A, Garcia, Jp, Shekar, K, Whitman, Gjr, Lorusso, R, and PELS‐1 Investigators, .

Published
2023

38. Guanine crystals discovered in bacteria

Author

Pavan, María Elisa, primary, Movilla, Federico, additional, Pavan, Esteban E., additional, Di Salvo, Florencia, additional, López, Nancy I., additional, and Pettinari, M. Julia, additional

Published
2022
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