96 results on '"Pettini, F."'
Search Results
2. Contributors
- Author
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Adhikari, Nilanjan, primary, Ahir, Gouri, additional, Al-Dossary, Hanan A., additional, Aljafary, Meneerah Abdurhman, additional, Al-Khater, Khulood Mohammed, additional, Al-Suhaimi, Ebtesam Abdullah, additional, Amin, Sk. Abdul, additional, Ashraf, Ghulam Md, additional, Assuhaimi, Reem A., additional, Balutia, Himani, additional, Bilgrami, Anwar L., additional, Campos-Iglesias, Diana, additional, Chaudhary, Sapana Sameer, additional, Choudhary, Sameer, additional, Cicaloni, V., additional, Dutt, Rohit, additional, Dutta Gupta, Sayan, additional, Elaissari, Abdelhamid, additional, Fotopoulos, I., additional, Freije, José M.P., additional, Ganeshpurkar, Ankit, additional, Garg, Vandana, additional, Gundala, Rishitha, additional, Gupta, Satya P., additional, Haddish-Berhane, Nahor, additional, Hadjipavlou-Litina, D., additional, Harish, B.S., additional, Jana, Srabanti, additional, Jha, Tarun, additional, Kumar, Deepak, additional, Kumar, Devendra, additional, Kumar, Sanjay, additional, Lavanya, R., additional, López-Otín, Carlos, additional, Madan, A.K., additional, Mahmood, Ayesha, additional, Makar, Subhajit, additional, Mandal, Tanima, additional, Nagpal, Ashima, additional, Parasrampuria, Dolly A., additional, Peperidou, A., additional, Pettini, F., additional, Poddar, Nitesh Kumar, additional, Pontiki, E., additional, Rai, Pankaj Kumar, additional, Ravinayagam, Vijaya, additional, Rawat, Sakshi, additional, Roy, Kuldeep K., additional, Saha, Priyanka, additional, Shehzad, Adeeb, additional, Shukla, Devendra, additional, Singh, Sushil Kumar, additional, Spiga, O., additional, Srivastava, Amit Kumar, additional, Tarhini, Mohamad, additional, Tonk, Rajiv Kumar, additional, Trezza, A., additional, Uppuluri, Kiran Babu, additional, Velayutham, Ravichandiran, additional, Verma, Saroj, additional, Yu, Alex, additional, and Zafar, Nadiah, additional
- Published
- 2020
- Full Text
- View/download PDF
3. Bleaching in vital teeth: a systematic review
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Dioguardi, M., Quarta, C., Spirito, F., Sovereto, D., Laneve, E., Zerman, N., Scarpa, M., Cazzolla, A. P., Pettini, F., Cantore, S., Di Cosola, M., Covelli, M., and Lo Muzio, L.
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Home bleaching ,Office bleaching ,Vital tooth bleaching ,Bleaching agents, Home bleaching, Office bleaching, Vital tooth bleaching ,Bleaching agents - Published
- 2022
4. Chapter 2 - Potential roles of protease inhibitors in anticancer therapy
- Author
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Trezza, A., Cicaloni, V., Pettini, F., and Spiga, O.
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- 2020
- Full Text
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5. A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype
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Mastrangelo F., Scacco S., Ballini A., Quaresima R., Gnoni A., Vito D. D. E., Scarano A., Dipalma G., Gargiulo Isacco C., Cantore S., Coscia M. F., Pettini F., Sammartino G., Cicciu M., Conti P., Lo Muzio L., Mastrangelo, F., Scacco, S., Ballini, A., Quaresima, R., Gnoni, A., Vito, D. D. E., Scarano, A., Dipalma, G., Gargiulo Isacco, C., Cantore, S., Coscia, M. F., Pettini, F., Sammartino, G., Cicciu, M., Conti, P., and Lo Muzio, L.
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Adult ,Male ,Subcutaneous Fat ,Osteogenic proliferation ,Cell Differentiation ,Pilot Projects ,Intra-Abdominal Fat ,Osteogenesis ,Differentiation ,Bone formation ,Human adult adipocytes derived stem cells (hASCs), Osteogenic proliferation and differentiation, Mesenchymal stem cells, Bone formation ,Humans ,Human adult adipocytes derived stem cells (hASCs) ,Mesenchymal stem cells ,Female ,Osteogenic proliferation and differentiation ,Cells, Cultured ,Mesenchymal stem cell - Abstract
To evaluate the different behavior of two different human adult adipocytes derived stem cells (hASCs) during proliferation and osteogenic differentiation.Human adult adipocytes stem cells (hAT-SCs) from visceral (hAV-SCs) and subcutaneous (hAS-SCs) sites were obtained after surgery procedures of seven patients. All samples were fully investigated and the different proliferation rates were evaluated. All MSCs clusters were cultured with an osteogenic and adipogenic differentiation medium. Homogeneous pools of Mesenchymal Stem Cells (MSCs) were confirmed by Flow-Cytometry Analysis (FACS) and Spectrophotometric Assay. The differentiated cells were eventually assessed for the expression of Alkaline Phosphatase (ALP), Alizarin Red (AR) and Oil Red-O (OR-O) detection, and analyzed by the Spectrophotometric Assay. After osteogenic differentiation, the cell clusters were incubated and analyzed with Real Time-Polymerase Chain Reaction (qRT-PCR) and fluorescence microscopy.The FACS analysis performed on hAT-SCs confirmed the homogenous presence of MSCs in all samples. The ALP, AR stain confirmed the osteogenic differentiation capacity of MSCs towards osteoblast-like-cells. The colorimetric cell metabolic activity (MTS) assay showed an increase in the proliferation rate with different values in both sets hAS-SCs vs. hAV-SCs.These in vitro findings of both hAS-SCs and hAV-SCs suggested an important role of these stem cells for future clinical use in bone regeneration. Indeed, the final outcomes suggested a better performance of cells coming from subcutaneous adipose tissue vs. those from visceral fat tissue.
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- 2019
6. Gender medicine: the impact of probiotics on male patients.
- Author
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Pacifici, L., Santacroce, L., Dipalma, G., Haxhirexha, K., Topi, S., Cantore, S., Altini, V., Pacifici, A., De Vito, D., Pettini, F., Cascella, G., Saini, R., Scacco, S., Ballini, Andrea, and Inchingolo, F.
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PROBIOTICS ,ENTEROCOCCUS faecalis ,ESCHERICHIA coli ,OPHTHALMOLOGY ,PSYCHOMOTOR disorders - Abstract
Purpose. Numerous studies in the literature confirm the importance of the use of probiotics in inflammatory states of the prostate in humans. Our pilot study aimed to test probiotics strains ability to improve urinary bacterial load in male subjects. Methods. Twenty healthy men aged 55-65 years, with recurrent urinatory infections were enrolled and randomized into 2 groups. Urine culturing to detect Enterobacteriaceae (Escherichia Coli and Enterococcus faecalis) was performed at baseline and at 12 weeks after the starting of the study. Results. We found that taking the probiotic reduces the bacterial load of E. coli and E. faecalis in urine cultures. The use of the probiotic in these inflammatory states does not affect the change in weight in the tested subjects. Conclusions. Our data confirm and improve the main results reported in the scientific literature on the importance of taking probiotics in prostatitis. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Effects of sea salt rinses on subjects undergone to oral surgery: a single blinded randomized controlled trial.
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Cantore, S., Ballini, A., Saini, Rajiv, Altini, V., De Vito, D., Pettini, F., Dipalma, G., and Inchingolo, F.
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SEA salt ,ORAL surgery ,RANDOMIZED controlled trials ,LYSOZYMES ,MOUTHWASHES - Abstract
Purpose. It has been customary to explain the dentally beneficial effects of xylitol and certain other natural compound as lysozyme and seas salt in terms of microbiological effects only. Several studies have tested the use of natural ingredients, alcohol and fluoride free, in mouthwashes. The purpose of this study was to evaluate a combined mouthwash formulation containing natural antibiofilm agents in oral care wound healing after routinely oral surgery (extraction) procedures. Methods. Patients were assigned following a blinded randomized controlled trial and divided into two groups, an experimental group (I = 15) and a control (placebo) group (II = 15). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated at ten and thirty days after extraction procedure. Pain and swelling were evaluated using the well-known visual analogue scale (VAS) scale throughout study period following extraction. The mean difference in Pre and Post values were compared among the groups. The change in pre-post score was analyzed using the paired t test. Results. An appreciable wound healing was seen in the experimental group when compared to the control sites, with no reported adverse effects. Four weeks postoperative patient's satisfaction level, to subjective and objective outcome measurements in documenting the result of a mouthwash treatment showed an interesting difference between groups. Conclusions. Since combined mouthwash formulations, containing natural/bioactive substances, could provide a cheap, safe and acceptable alternative in oral care, further studies will also be required to study these effects and their mechanism of action in detail. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Cytokine, Chemokine, and Growth Factor Profile Characterization of Undifferentiated and Osteoinduced Human Adipose-Derived Stem Cells
- Author
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Mussano, F., primary, Genova, T., additional, Corsalini, M., additional, Schierano, G., additional, Pettini, F., additional, Di Venere, D., additional, and Carossa, S., additional
- Published
- 2017
- Full Text
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9. A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype.
- Author
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MASTRANGELO, F., SCACCO, S., BALLINI, A., QUARESIMA, R., GNONI, A., DE VITO, D., SCARANO, A., DIPALMA, G., ISACCO, C. GARGIULO, CANTORE, S., COSCIA, M. F., PETTINI, F., SAMMARTINO, G., CICCIÙ, M., CONTI, P., and LO MUZIO, L.
- Abstract
OBJECTIVE: To evaluate the different behavior of two different human adult adipocytes derived stem cells (hASCs) during proliferation and osteogenic differentiation. PATIENTS AND METHODS: Human adult adipocytes stem cells (hAT-SCs) from visceral (hAV-SCs) and subcutaneous (hAS-SCs) sites were obtained after surgery procedures of seven patients. All samples were fully investigated and the different proliferation rates were evaluated. All MSCs clusters were cultured with an osteogenic and adipogenic differentiation medium. Homogeneous pools of Mesenchymal Stem Cells (MSCs) were confirmed by Flow-Cytometry Analysis (FACS) and Spectrophotometric Assay. The differentiated cells were eventually assessed for the expression of Alkaline Phosphatase (ALP), Alizarin Red (AR) and Oil Red-O (OR-O) detection, and analyzed by the Spectrophotometric Assay. After osteogenic differentiation, the cell clusters were incubated and analyzed with Real Time-Polymerase Chain Reaction (qRT-PCR) and fluorescence microscopy. RESULTS: The F ACS a nalysis p erformed on hAT-SCs confirmed the homogenous presence of MSCs in all samples. The ALP, AR stain confirmed the osteogenic differentiation capacity of MSCs towards osteoblast-like-cells. The colorimetric cell metabolic activity (MTS) assay showed an increase in the proliferation rate with different values in both sets hAS-SCs vs. hAV-SCs. CONCLUSIONS: These in vitro findings of both hAS-SCs and hAV-SCs suggested an important role of these stem cells for future clinical use in bone regeneration. Indeed, the final outcomes suggested a better performance of cells coming from subcutaneous adipose tissue vs. those from visceral fat tissue. [ABSTRACT FROM AUTHOR]
- Published
- 2019
10. Proposal for an MRPC system with high-precision timing in the LVD structure
- Author
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Abbrescia, M, Agafonova, N. Yu, Aglietta, M., Agostinelli, A., Aiola, S., Akindinov, A., Alici, A., Amati, E., Amerigo, S., Angelotti, A. M., Antolini, R., Antonioli, P., Arcelli, S., Asta, A., Atalmi, A., Attanasi, A., Avanzini, C., Baldini Ferroli, R., Bari, G., Bartolucci, S., Belligan, N., Bellini, F., Bencivenni, G., Bessi, C., Boi, M., Bologna, M., Bonardi, A., Bonetti, C., Borromeo, A., Bossini, E., Boyarkin, V. V., Bragagnolo, A., Bressan, E., Brunelli, C., Brunetti, G., Brunos, G., Burato, M., Burzi, S., Calemasi, D., Calvari, F., Cannas, A., Cara Romeo, G., Cardillo, A., Cari, A., Carli, M., Cassinadri, A., Celati, F., Celano, M., Chiaranda, L., Chiavassa, A., Chinnici, L., Cicalo, C., Cifarelli, L., Civili, I., Coccetti, F., Coccia, E., Cocuzza, S., Corti, M., Dambrosio, G., D'Amico, C., De Angelo, N., DE CARO, Annalisa, DE GRUTTOLA, Daniele, Del Chiaro, R., Del Corda, S., Del Corral, F., DE PASQUALE, Salvatore, Deplano, S., Di Giovanni, A., D'Incecco, M., Dispensa, E., Di Carlo, L., Di Crescenzo, E., Di Pietro, F., Di Staso, G., Di Vittorio, P., Dondarini, I., Dreucci, M., Evangelista, M. R., Evans, L., Fabbri, F. L., Falchi, G., Fanti, B., Fantini, A., Fantini, G., Ferrari, S., Finelli, S., Folino, R., Forni, E., Forte, P., Frolov, V., Fulgione, W., FUSCO GIRARD, Mario, La Teana, A., Londrillo, L., Lorenzo, A. R., Lupo, F., Gatti, S., Gaias, A., Galante, L., Galeotti, P., Gallone, M. G., Garbini, M., Gargano, A., Garrisi, M., Gemme, G., Ghia, P. L., Giacconi, P., Giusti, P., Gnesi, I., Guidi, S., Grishuk, Yu, Grotti, M., Guerzoni, B., Gustavino, C., Gustavino, S., Hatzifotiadou, D., Imperio, T., Indelicato, S., Jung, H., Kemp, E., Kim, D. W., Kim, M., Kim, J., Kiselev, S., Kuznetsov, V. V., Kuznetsov, V. A., La Rocca, P., Lee, S., Li, S., Libertini, L., Librizzi, F., Lo Mastro, A., Lucchesi, D., Maccari, A., Maggiora, A., Maggisano, M. P., Magistrale, G., Magli, G., Malguin, A. S., Mal'Kevich, D., Mattina, G., Margotti, A., Maroi, R., Marrone, S., Massai, M., Mastrodomenico, M., Matarese, A., Mazzone, A., Mazzotta, U., Melley, S., Memme, A., Miozzi, S., Moro, R., Murgia, M., Nania, R., Natali, G., Natucci, B., Nedosekin, A., Noferini, F., Nurisso, N., Nuti, S., Paccapelo, A. M., Paccoia, A., Pagano, Paola, Palombella, L., Panareo, M., Paoletti, R., Paravano, A., Pascale, R., Perasso, L., Perrone, D., Persiani, R., Persico, M. C., Pesci, A., Pettini, F., Piazzola, G., Pilo, F., Piragino, G., Pizzigoni, G., Pless, I. A., Porcu, M., Poggi, F., Polverino, E., Porta, A., Pozzanghera, R., Prati, A., Preghenella, R., Pulze, M., Quattromini, O., Ranieri, G., Rebagnati, S., Regano, A., Riggi, F., Righini, G., Rioli, A., Romano, F., Ronchini, L., Rossi, L., Rossi, R., Rossino, M., Rubino, M. G., Ruggeri, A., Russo, G., Ryasny, V. G., Ryazhskaya, O. G., Sartorelli, G., Scapparone, E., Schina, R., Scioli, G., Scribano, A., Selvi, M., Senes, E., Serci, S., Siddi, E., Sivori, G., Spampinato, G., Spandre, G., Squarcia, S., Stirparo, G., Stragiotti, A., Strizzai, L., Taiuti, M., Tarantino, F., Tosello, F., Troiano, C., Urbani, S., Usai, C., Verboso, F., Veseli, A., Vigna, A., Vigorito, C., Voloshin, K., Votano, L., Wenninger, H., Williams, M. C. S., Yakushev, V. F., Zaccaro, M., Zampolli, C., Zarri, I., Ziccardi, A., Zichichi, A., Zoffoli, G., Zouyevski, R., Zucchini, A., Abbrescia, M., Agafonova, N. Y., Aglietta, M., Agostinelli, A., Aiola, S., Akindinov, A., Alici, A., Amati, E., Amerigo, S., Angelotti, A. M., Antolini, R., Antonioli, P., Arcelli, S., Asta, A., Atalmi, A., Attanasi, A., Avanzini, C., Baldini Ferroli, R., Bari, G., Bartolucci, S., Belligan, N., Bellini, F., Bencivenni, G., Bessi, C., Boi, M., Bologna, M., Bonardi, A., Bonetti, C., Borromeo, A., Bossini, E., Boyarkin, V. V., Bragagnolo, A., Bressan, E., Brunelli, C., Brunetti, G., Brunos, G., Burato, M., Burzi, S., Calemasi, D., Calvari, F., Cannas, A., Cara Romeo, G., Cardillo, A., Cari, A., Carli, M., Cassinadri, A., Celati, F., Celano, M., Chiaranda, L., Chiavassa, A., Chinnici, L., Cicalo, C., Cifarelli, L., Civili, I., Coccetti, F., Coccia, E., Cocuzza, S., Corti, M., Dambrosio, G., D'Amico, C., De Angelo, N., De Caro, A., De Gruttola, D., Del Chiaro, R., Del Corda, S., Del Corral, F., De Pasquale, S., Deplano, S., Di Giovanni, A., D'Incecco, M., Dispensa, E., Di Carlo, L., Di Crescenzo, E., Di Pietro, F., Di Staso, G., Di Vittorio, P., Dondarini, I., Dreucci, M., Evangelista, M. R., Evans, L., Fabbri, F. L., Falchi, G., Fanti, B., Fantini, A., Fantini, G., Ferrari, S., Finelli, S., Folino, R., Forni, E., Forte, P., Frolov, V., Fulgione, W., Fusco Girard, M., La Teana, A., Londrillo, L., Lorenzo, A. R., Lupo, F., Gatti, S., Gaias, A., Galante, L., Galeotti, P., Gallone, M. G., Garbini, M., Gargano, A., Garrisi, M., Gemme, G., Ghia, P. L., Giacconi, P., Giusti, P., Gnesi, I., Guidi, S., Grishuk, Y., Grotti, M., Guerzoni, B., Gustavino, C., Gustavino, S., Hatzifotiadou, D., Imperio, T., Indelicato, S., Jung, H., Kemp, E., Kim, D. W., Kim, M., Kim, J., Kiselev, S., Kuznetsov, V. V., Kuznetsov, V. A., La Rocca, P., Lee, S., Li, S., Libertini, L., Librizzi, F., Lo Mastro, A., Lucchesi, D., Maccari, A., Maggiora, A., Maggisano, M. P., Magistrale, G., Magli, G., Malguin, A. S., Mal'Kevich, D., Mattina, G., Margotti, A., Maroi, R., Marrone, S., Massai, M., Mastrodomenico, M., Matarese, A., Mazzone, A., Mazzotta, U., Melley, S., Memme, A., Miozzi, S., Moro, R., Murgia, M., Nania, R., Natali, G., Natucci, B., Nedosekin, A., Noferini, F., Nurisso, N., Nuti, S., Paccapelo, A. M., Paccoia, A., Pagano, P., Palombella, L., Panareo, Marco, Paoletti, R., Paravano, A., Pascale, R., Perasso, L., Perrone, D., Persiani, R., Persico, M. C., Pesci, A., Pettini, F., Piazzola, G., Pilo, F., Piragino, G., Pizzigoni, G., Pless, I. A., Porcu, M., Poggi, F., Polverino, E., Porta, A., Pozzanghera, R., Prati, A., Preghenella, R., Pulze, M., Quattromini, O., Ranieri, G., Rebagnati, S., Regano, A., Riggi, F., Righini, G., Rioli, A., Romano, F., Ronchini, L., Rossi, L., Rossi, R., Rossino, M., Rubino, M. G., Ruggeri, A., Russo, G., Ryasny, V. G., Ryazhskaya, O. G., Sartorelli, G., Scapparone, E., Schina, R., Scioli, G., Scribano, A., Selvi, M., Senes, E., Serci, S., Siddi, E., Sivori, G., Spampinato, G., Spandre, G., Squarcia, S., Stirparo, G., Stragiotti, A., Strizzai, L., Taiuti, M., Tarantino, F., Tosello, F., Troiano, C., Urbani, S., Usai, C., Verboso, F., Veseli, A., Vigna, A., Vigorito, C., Voloshin, K., Votano, L., Wenninger, H., Williams, M. C. S., Yakushev, V. F., Zaccaro, M., Zampolli, C., Zarri, I., Ziccardi, A., Zichichi, A., Zoffoli, G., Zouyevski, R., and Zucchini, A.
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Physics ,Large Hadron Collider ,Traverse ,Physics::Instrumentation and Detectors ,Opera ,Detector ,Structure (category theory) ,General Physics and Astronomy ,Theoretical physics ,Computer engineering ,Simple (abstract algebra) ,High Energy Physics::Experiment ,Cosmic muons ,Neutrino - Abstract
The purpose of this paper is to present a project in order to verify -without the need of knowing the distance CERN-Gran Sasso- the discovery made by the OPERA Collaboration concerning the speed of the CERN neutrinos. The project consists of two parts. A simple one and a less simple one. Both have the great advantage of being totally independent of the knowledge of the distance, ≃ 732 km, between the two Labs, CERN and LNGS, where the neutrinos are produced and detected, respectively. The "simple" version of this project is based on the high-energy horizontal cosmic muons, which traverse LVD and OPERA detectors, thus allowing to cross-calibrate the timing systems of both experiments in a way which is totally independent of the TOF measurements of CNGS. This component of the project is being studied in collaboration with the OPERA group, as the time stabilities of both experiments are needed. In fact it is since a long time that the two groups are engaged with this problem. In this paper we will present and discuss the "less simple" part which allows to establish, at the highest possible level of accuracy, if (v > c) effects really exist.
- Published
- 2012
11. Management of oral pemphigus vulgaris: A case report and a clinical update
- Author
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Pettini, F, primary, Ballini, A, additional, Capodiferro, S, additional, Cantore, S, additional, Cirulli, N, additional, Garofalo, A, additional, Coscia, MF, additional, De Vito, D, additional, and Foti, C, additional
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- 2015
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12. Use of platelet rich fibrin and Bio-OSS/SINT-Oss for implant-prosthetic rehabilitation in maxillary atrophy with sinus pathology: A 48-month follow-up
- Author
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Inchingolo, F, primary, Ballini, A, additional, Mura, SA, additional, Farronato, D, additional, Cirulli, N, additional, Pettini, F, additional, Gheno, E, additional, Vermesan, D, additional, Pederzoli, P, additional, Resta, G, additional, Caprio, M, additional, Muollo, F, additional, Marinelli, G, additional, Inchingolo, AD, additional, Malcangi, G, additional, Cantore, S, additional, Del Corso, M, additional, De Benedittis, M, additional, Inchingolo, AM, additional, Serafini, M, additional, Diteodoro, S, additional, Schinco, F, additional, Cagiano, R, additional, De Vito, D, additional, Cortelazzi, R, additional, and Dipalma, G, additional
- Published
- 2015
- Full Text
- View/download PDF
13. Quality of Life in Fibromyalgia Patients with Craniomandibular Disorders
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Di Venere, D, primary, Corsalini, M, additional, Stefanachi, G, additional, Tafuri, S, additional, De Tommaso, M, additional, Cervinara, F, additional, Re, A, additional, and Pettini, F, additional
- Published
- 2015
- Full Text
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14. Craniomandibular Disorders and Burning Mouth Syndrome in Removable Denture Wearers
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Corsalini, M., primary, Venere, D., additional, Stefanachi, G., additional, Demelio, A., additional, Tafuri, S., additional, Pettini, F., additional, and Petruzzi, M., additional
- Published
- 2015
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15. OBSTRUCTIVE SITE LOCALIZATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME: A COMPARISON BETWEEN OTOLARYNGOLOGIC DATA AND CEPHALOMETRIC VALUES.
- Author
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DI VENERE, D., CORSALINI, M., NARDI, G. M., LAFORGIA, A., GRASSI, F. R., RAPONE, B., and PETTINI, F.
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SLEEP apnea syndromes ,OTOLARYNGOLOGY ,CEPHALOMETRY - Abstract
Purpose. Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory disorder characterized by repeated obstructive episodes affecting upper airways. This study aims at examining the anatomical craniofacial and pharyngeal characteristics of the patient as to identify the obstructive site which triggers the pathologic process. Correlations between otolaryngologic data observed in the patient and the cephalometric ones for the identification of the obstructive site were also highlighted. Materials and methods. We worked on a sample of 16 patients, 12 males and 4 females, attended to at the Otolaryngology Operative Unit of Bari University Hospital. The patients underwent an otolaryngologic (ORL) diagnostic procedure which provided for ApneaGraph (AG) recording, and a dental diagnostic procedure with cephalometric assessment. Results.The statistical analysis highlighted a strict correlation between the otolaryngologic value of AHI and the cephalometric values of the ANB angle, with the distance between the hyoid bone and the mandibular plane and with the distance between the hyoid bone and the plane passing between C3 and Me. Conclusions. We observed a concurrence between the ORL diagnosis of the obstruction level assessed with AG and the cephalometric values regarding respiratory tracts (IPAS and SAS). More precisely, we observed the correlation between the otolaryngologic value of AHI with cephalometric values of the ANB angle, with the distance between hyoid bone and mandibular plan, and with the distance between the hyoid bone and the plane passing between C3 and Me. Furthermore, the identification of the caudal position of the hyoid bone can be considered an alarm bell in the diagnosis of severe OSAS. [ABSTRACT FROM AUTHOR]
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- 2017
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16. EARLY MANDIBULAR CANINE-LATERAL INCISOR TRANSPOSITION: CASE REPORT.
- Author
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DI VENERE, D., NARDI, G. M., LACARBONARA, V., LAFORGIA, A., STEFANACHI, G., CORSALINI, M., GRASSI, F. R., RAPONE, B., and PETTINI, F.
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TOOTH eruption ,DENTAL occlusion ,TREATMENT duration ,PATIENT satisfaction - Abstract
Purpose. The main aim of the present study is to present a case of mandibular transposition between lateral incisor and canine in a paediatric patient. Materials and methods. A fixed multibracket orthodontic treatment was performed by means of a modified welded arch as to correct the transposition and obtaining a class I functional and symmetrical occlusion, also thanks to the early diagnosis of the eruption anomaly. Results. Our case report shows that a satisfactory treatment of mandibular transpositions is obtained when detected at an early stage of the tooth development. Conclusions. The main treatment options to be taken into consideration in case of a mandibular transposition are two: correcting the transposition or aligning it leaving the dental elements in their transposed order; in both cases, the followups show a stable condition, maintained without relapses. Several factors, such as age of the patient, occlusion, aesthetics, patient's collaboration, periodontal support and duration of treatment have to be considered as to prevent potential damage to dental elements and support appliances. The choice between the two treatment approaches for mandibular lateral incisor/canine transpositions mainly depends on the time the anomaly is detected. [ABSTRACT FROM AUTHOR]
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- 2017
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- View/download PDF
17. CORRELATION BETWEEN PARODONTAL INDEXES AND ORTHODONTIC RETAINERS: PROSPECTIVE STUDY IN A GROUP OF 16 PATIENTS.
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DI VENERE, D., PETTINI, F., NARDI, G. M., LAFORGIA, A., STEFANACHI, G., NOTARO, V., RAPONE, B., GRASSI, F. R., and CORSALINI, M.
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ORTHODONTIC appliances , *GINGIVAL recession , *PERIODONTAL disease treatment , *ORTHODONTIC retainers - Abstract
Purpose. Fixed retainers are used to stabilize dental elements after orthodontic treatment. Being it a permanent treatment, it is necessary to instruct patients about a constant and continuous monitoring of their periodontal conditions and a correct oral hygiene. The aim of this study was to highlight the possible adverse effects of bonded retainers on parameters correlated to the health conditions of periodontal tissues. Materials and methods. We selected 16 patients, under treatment in the Orthodontics Department of University of Bari Dental School, who had undergone a lingual retainer insertion at the end of the orthodontic treatment. The patients were then divided into two groups (Control Group and Study Group) and monitored for 3 and 36 months, respectively. The following indexes were taken into consideration: gingival index (GI), plaque index (PI) and the presence of calculus (Calculus Index, CI), the probing depth and the presence of gingival recession on the six inferior frontal dental elements. Results. After the observation was carried out, any of the patients showed periodontal sockets and gingival recession. In the Study Group, only 1 patient had a PI score=3, the 7 left had scores between 0.66 and 2.83. In the Control Group, one patient had score=0, the other ones showed values between 0.5 and 1.66. The mean GI in the Study Group peaked at a score of 2.83, the minimum was 0.66; whereas in the Control Group the maximum value was 2 and the minimum 0.66. The CI in the Group Study was between 1 and 2. In the Control Group it was absent in only 1 patient, whereas in the remaining 7, it had a value between 0.3 and 1. The clinical data were studied by means of the Wilcoxon test. We found a statistically significant difference for what concerns the Plaque Indexes (PI) (P>0.05) and Calculus Indexes (CI) (P>0.1) in both groups, with higher scores in the Study Group, having retainers for 36 months. Any statistically significant difference was calculated for the GI. Conclusions. We can therefore conclude that patients with lingual retainers need periodontal hygiene and treatment as to prevent, in the course of time, periodontal damages non-detectable in short-term. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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18. ORAL HYGIENE IN PATIENTS WITH ORAL CANCER UNDERGOING CHEMOTHERAPY AND/OR RADIOTHERAPY AFTER PROSTHESIS REHABILITATION: PROTOCOL PROPOSAL.
- Author
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RAPONE, B., NARDI, G. M., DI VENERE, D., PETTINI, F., GRASSI, F. R., and CORSALINI, M.
- Subjects
ORAL cancer ,ORAL hygiene ,CANCER chemotherapy ,DENTURES ,RADIOTHERAPY - Abstract
Purpose. This study was aimed at assessing the effectiveness and the importance of an oral hygiene (OH) protocol in patients undergoing radiation therapy and chemotherapy after prosthesis rehabilitation, in order to reduce or minimize oral complications. Materials and methods. This study was carried out at the Department of Dental Science, at the University of Bari-Italy from December 2012 to December 2015 on 34 selected patients with primary oral cancer undergoing chemotherapy and radiotherapy after prosthesis rehabilitation. They were divided into 2 groups according to their age, sex and cancer therapy. Seventeen patients were assigned to the control group and seventeen in the experimental one. In the experimental group (Table 1), patients underwent an oral hygiene protocol whereas in the control group (Table 2) patients received the usual care provided within the clinical setting. All the patients gave written informed consent. It has been asked and obtained the authorisation from the Ethics Committee of the Dental Science and Surgery Department. Results. Results show that in patients undergoing the oral hygiene protocol, the complications and the risks of infection and permanent dental problems have been minimized. Indeed, of the seventeen patients undergoing the OH protocol, 70% obtained positive results and were satisfied with the program outcome. Conclusions. The role of the health care providers is essential to educate patients to adhere to the prescribed treatments and reinforce their motivation in oral hygiene. The oral hygiene procedures prevent and ameliorate oral complications due to the radiation therapy and chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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19. CORRELATION BETWEEN DENTO-SKELETAL CHARACTERISTICS AND CRANIOMANDIBULAR DISORDERS IN GROWING CHILDREN AND ADOLESCENT ORTHODONTIC PATIENTS: RETROSPECTIVE CASE-CONTROL STUDY.
- Author
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DI VENERE, D., GAUDIO, R. M., LAFORGIA, A., STEFANACHI, G., TAFURI, S., PETTINI, F., SILVESTRE, F., PETRUZZI, M., and CORSALINI, M.
- Subjects
DENTAL occlusion - Abstract
Purpose. The aim of this retrospective case-control study was to identify, in a group of growing children and adolescents affected by malocclusion, specific dento-skeletal characteristics which could be correlated to the onset, in the above-mentioned subjects, of craniomandibular disorders (CMD). Materials and methods. Among the patients treated at the Paedodontics and Orthodontics department of Bari Dental School, we recruited a group of patients with malocclusion and symptoms of temporomandibular disorders, as an experimental group. We considered as controls those patients who, match-paired to their skeletal class depending on the ANB angle, did not show any CMD sign or symptom. Results. Of the 128 examined patients, 15 showed signs and/or symptoms of CMD (11.7%). When compared to 15 patients non-affected by CMD, we could not detect statistically significant differences in both skeletal and occlusal characteristics. It is still interesting to notice how in CMD patients, characteristics of skeletal hyperdivergence are often to be found. Conclusions. The present study seems to confirm that in growing children and adolescents, the presence of signs and/or symptoms of CMD is not associable to a specific vertical skeletal growth pattern or to other specific occlusal characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2016
20. Fotoelasticità tridimensionale nello studio di problematiche odontoiatriche
- Author
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Galietti, Umberto, Pappalettere, Carmine, Ventura, D, Crincoli, V, and Pettini, F.
- Published
- 1995
21. Root resorption of replanted teeth: an SEM study
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Pettini, F., primary and Pettini, P., additional
- Published
- 1998
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22. Sulfide Influence on Polymorphonuclear Functions: A Possible Role for CA2+Involvement
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Mariggiò, M. A., primary, Pettini, F., additional, and Fumarulo, R., additional
- Published
- 1997
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23. Salivary up-regulation of human polymorphonuclear leucocyte chemotaxis and adhesion-molecule expression
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Pettini, F., primary, Pettini, P., additional, Laforgia, A., additional, Coluccia, M., additional, De Rinaldis, P., additional, and Fumarulo, R., additional
- Published
- 1994
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24. Root resorption of replanted teeth: an SEM study.
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Pettini, F. and Pettini, P.
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TOOTH transplantation ,INCISORS ,SCANNING electron microscopes ,RESORPTION (Physiology) ,TOOTH roots ,COLLAGEN - Abstract
Two replanted and subsequently expelled upper central incisors were observed under a scanning electron microscope to study the changes brought about by root resorption . The severity of resorption and the distribution of the affected areas were different in the two specimens. In the first case, large, deep excavations were found along a continuous home effect which exposed the opposite root canal wall. Bacteria-like elements were found on the bottom of the croded areas both on the outer and on the inner root surfaces. In the second case, resorption denuded the apical portion of the metal post. Erosive lacunae were visible in some areas while tubiform excavation were present close to the apical magin exposing the collagen network. The roots in the first case likely underwent inflammatory resorption while replacement resorption was thought to have occurred in the case. [ABSTRACT FROM AUTHOR]
- Published
- 1998
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25. Sulfide Influence on Polymorphonuclear Functions: A Possible Role for CA2++ Involvement.
- Author
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Mariggi, M. A., Pettini, F., and Fumarulo, R.
- Published
- 1997
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26. PERIODONTAL DISEASE AND BONE PATHOGENESIS: THE CROSSTALK BETWEEN CYTOKINES AND PORPHYROMONAS GINGIVALIS
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Ballini, A., C Antore, S., Farronato, D., Cirulli, N., Inchingolo, F., Papa, F., Malcangi, G., Inchingolo, A. D., Dipalma, G., Sardaro, N., Lippolis, R., Santacroce, L., Coscia, M. F., Pettini, F., Vito, D., and Salvatore Scacco
- Subjects
Periodontium ,citrullination ,periodontal disease ,Osteoclasts ,Pattern Recognition ,Autoantigens ,Arthritis, Rheumatoid ,bone loss ,Rheumatoid ,Receptors ,Humans ,Bone Resorption ,Adhesins, Bacterial ,Saliva ,anti-cyclic citrullinated peptide antibodies ,Arginase ,Autoantibodies ,Biofilms ,Citrulline ,Cysteine Endopeptidases ,Cytokines ,Disease Progression ,Gene Expression Regulation, Bacterial ,Gingival Crevicular Fluid ,Inflammation Mediators ,Osteoporosis ,Periodontal Diseases ,Porphyromonas gingivalis ,Protein Processing, Post-Translational ,RANK Ligand ,Receptors, Pattern Recognition ,Virulence ,Protein Processing ,Arthritis ,Bacterial ,Post-Translational ,Adhesins ,Gene Expression Regulation ,Gingipain Cysteine Endopeptidases - Abstract
Periodontal disease is the most frequent cause of tooth loss among adults. It is defined as a plaque-induced inflammation of the periodontal tissues that results in a loss of support of the affected teeth. This process is characterized by destruction of the periodontal attachment apparatus, increased bone resorption with loss of crestal alveolar bone, apical migration of the epithelial attachment, and formation of periodontal pockets. Although the presence of periodontal pathogens such as Porphyromonas gingivalis is a prerequisite, the progression of periodontal disease is dependent on the host response to pathogenic bacteria that colonize the tooth surface. Nowadays, a growing body of literature has accumulated to investigate the association between bone diseases, periodontal pathogens and periodontal diseases. The integration of pathogen-associated molecular patterns from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that present either a pro- and/or anti-inflammatory role and the activation of mechanisms of controlling this and the related disease, such as osteoporosis and rheumatoid arthritis. This review focuses on the evidence and significance of bone host cell invasion by Porphyromonas gingivalis in the pathogenesis of bone disorders, as well as the different lines of evidence supporting the role of cytokines in bone diseases.
27. Sulfide influence on polymorphonuclear functions: A possible role for Ca2+ involvement
- Author
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Mariggiò, M. A., Pettini, F., and ruggiero fumarulo
28. Cytogenetic genotoxic investigation in peripheral blood lymphocytes of subjects with dental composite restorative filling materials
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Pettini, F., Savino, M., Corsalini, M., Cantore, S., and Andrea Ballini
29. Chlorhexidine effects on polymorphonuclear leucocyte degranulation and LFA-1 expression
- Author
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Pettini, F., Pettini, P., Mariggio, A., and ruggiero fumarulo
30. Non-Surgical periodontal management in scleroderma disease patients
- Author
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Laforgia, A., Corsalini, M., Stefanachi, G., Tafuri, S., Andrea Ballini, Pettini, F., and Di Venere, D.
31. The pivotal role of oral microbiota in health and disease
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Santacroce, L., Sardaro, N., Topi, S., Pettini, F., Bottalico, L., Stefania Cantore, Cascella, G., Prete, R. D., Dipalma, G., and Inchingolo, F.
32. Effect of activated charcoal probiotic toothpaste containing Lactobacillus Paracasei and xylitol on dental caries: A randomized and controlled clinical trial
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Ballini, A., Stefania Cantore, Saini, R., Pettini, F., Fotopoulou, E. A., Saini, S. R., Georgakopoulos, I. P., Dipalma, G., Isacco, C. G., and Inchingolo, F.
33. Transmission of Nonviral Sexually Transmitted Infections and Oral Sex
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Vito Crincoli, Andrea Ballini, Paolo Romita, Stefania Cantore, Danila De Vito, V. Montenegro, Biagio Rapone, Felice Roberto Grassi, Laura Fatone, Letizia Perillo, Caterina Foti, Annarita Antelmi, Giovanni Miniello, Francesco Pettini, Ballini, A, Cantore, S, Fatone, L, Montenegro, V, DE VITO, D, Pettini, F, Crincoli, V, Antelmi, A, Romita, P, Rapone, B, Miniello, G, Perillo, Letizia, Grassi, Fr, and Foti, C.
- Subjects
Male ,Sexual behavior ,medicine.medical_specialty ,Oral sex ,Nonviral-sexually transmissible infection ,Sexual health ,Urology ,Endocrinology, Diabetes and Metabolism ,MEDLINE ,Sexually Transmitted Diseases ,Human sexuality ,Endocrinology ,Pregnancy ,medicine ,Humans ,Pregnancy Complications, Infectious ,Genital intercourse ,Reproductive health ,Gynecology ,business.industry ,Vaginal microbicide ,Transmission (medicine) ,Public health ,Orogenital sexual activity ,Clinical trial ,Psychiatry and Mental health ,Reproductive Medicine ,Family medicine ,Female ,business ,Sexual function - Abstract
Introduction Oral sex is usually considered a lower‐risk sexual activity when compared with sex, but it is frequently the cause of sexually transmitted infections (STI). In particular, STI transferred through oral sex might have no visible symptoms, depending on the type of infection. Aims The aim of this study is to review the literature about the role of oral sex in the transmission of nonviral STI. Main Outcome Measures State‐of‐the‐art information in the area of STI in relation to sexual function and self–care, this last important for development of STI prevention products such as vaginal microbicides. Sexual behaviors assessed focusing on receiving oral sex and giving oral sex. Methods A search of the main electronic databases including registers of clinical controlled trials was performed in addition to a hand search of the most relevant Journals. The following electronic databases were searched: PubMed, Embase, Google Scholar, literature review of research articles, and public health department Internet Web sites, for the period of 1945–2011. In addition to searching the Clinical Trials Registry at the US National Institutes of Health, we also used the meta Register of Controlled Trials and the Cochrane Central Register of Controlled Trials. Results STI affect the mucous membranes both directly and indirectly producing characteristic diagnostic signs and lesions. Daily dental clinical activity needs an appropriate knowledge of any kind of oral lesions‐related STI. The reader is offered a practical approach with clinically relevant recommendations that may prove useful in his/her daily practice when dealing with STI. Conclusions. These data provide a foundation for understanding diverse STI. We advise physicians to be receptive to discuss sexuality issues and provide patients with adequate therapy. Ballini A, Cantore S, Fatone L, Montenegro V, De Vito D, Pettini F, Crincoli V, Antelmi A, Romita P, Rapone B, Miniello G, Perillo L, Grassi FR, and Foti C. Transmission of nonviral sexually transmitted infections and oral sex. J Sex Med 2012;9:372–384.
- Published
- 2012
34. Surgical treatment of gingival overgrowth with 10 years of follow-up
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Adele Scattarella, Felice Roberto Grassi, Letizia Perillo, Francesco Papa, Angela Dituri, Andrea Ballini, Maria Virginia Bux, Francesco Pettini, Teodoro Romanazzo, Gianna Maria Nardi, Roberto Gianfranco Carlaio, Vito Crincoli, Stefania Cantore, Ballini, A, Scattarella, A, Crincoli, V, Carlaio, Rg, Papa, F, Perillo, Letizia, Romanazzo, T, Bux, Mv, Nardi, Gm, Dituri, A, Cantore, S, Pettini, F, and Grassi, Fr
- Subjects
Adult ,Male ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,Clinical Neurology ,Dentistry ,Oral hygiene ,Lesion ,Gingivitis ,lcsh:RC581-951 ,medicine ,Humans ,General Dentistry ,Gingival Overgrowth ,business.industry ,Dentistry(all) ,Research ,Surgery ,Masticatory force ,Major duodenal papilla ,Treatment Outcome ,Otorhinolaryngology ,Oral and maxillofacial surgery ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Follow-Up Studies ,Gingival margin - Abstract
Background In some pathological conditions, gingivitis caused by plaque accumulation can be more severe, with the result of an overgrowth. Nevertheless, the overgrowth involves the gingival margin with extension to the inter-dental papilla. The lesion may involve the inter-proximal spaces, and become so extensive that the teeth are displaced and their crowns covered. Severe overgrowth may lead to impairment in aesthetic and masticatory functions, requiring surgical excision of the excessive tissue. Aim of this study is to describe an operative protocol for the surgical treatment of localized gingival overgrowth analyzing the surgical technique, times and follow-up. Methods A total of 20 patients were enrolled and underwent initial, non surgical, periodontal treatment and training sessions on home oral hygiene training. The treatment plan involved radical exeresis of the mass followed by positioning of an autograft of connective tissue and keratinized gingiva. Results During 10 years of follow-up, all the grafts appeared well vascularized, aesthetically satisfactory, and without relapse. Conclusions Periodontal examinations, surgical procedures, and dental hygiene with follow-up are an essential part of the treatment protocol. However, additional effort is needed from the patient. Hopefully, the final treatment result makes it all worthwhile.
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35. Electrophysiology, molecular modelling, and functional analysis of the effects of dietary quercetin and flavonoid analogues on K ir 6.1 channels in rat stomach fundus smooth muscle.
- Author
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Pettini F, Spiga O, Furini S, and Fusi F
- Subjects
- Rats, Animals, Pinacidil pharmacology, Quercetin pharmacology, Molecular Docking Simulation, Potassium Channels metabolism, Muscle, Smooth metabolism, Electrophysiology, Rutin, Diet, Sulfonylurea Receptors metabolism, Vasodilator Agents pharmacology, Gastric Fundus metabolism
- Abstract
Flavonoids, ubiquitously distributed in the plant world, are regularly ingested with diets rich in fruit, vegetables, wine, and tea. During digestion, they are partially absorbed in the stomach. The present work aimed to assess the in vitro effects of quercetin and ten structurally related flavonoids on the rat gastric fundus smooth muscle, focussing on ATP-dependent K
+ (Kir 6.1) channels, which play a central role in the regulation of resting membrane potential, membrane excitability and, consequently, of gastric motility. Whole-cell currents through Kir 6.1 channels (IKir6.1 ) were recorded with the patch-clamp technique and the mechanical activity of gastric fundus smooth muscle strips was studied under isometric conditions. Galangin ≈ tamarixetin > quercetin > kaempferol > isorhamnetin ≈ luteolin ≈ fisetin > (±)-taxifolin inhibited pinacidil-evoked, glibenclamide-sensitive IKir6.1 in a concentration-dependent manner. Morin, rutin, and myricetin were ineffective. The steric hindrance of the molecule and the number and position of hydroxyl groups on the B ring played an important role in the activity of the molecule. Molecular docking simulations revealed a possible binding site for flavonoids in the C-terminal domain of the Kir 6.1 channel subunit SUR2B, in a flexible loop formed by residues 251 to 254 of chains C and D. Galangin and tamarixetin, but not rutin relaxed both high K+ - and carbachol-induced contraction of fundus strips in a concentration-dependent manner. Furthermore, both flavonoids shifted to the right the concentration-relaxation curves to either pinacidil or L-cysteine constructed in strips pre-contracted by high K+ , rutin being ineffective. In conclusion, IKir6.1 inhibition exerted by dietary flavonoids might counterbalance their myorelaxant activity, affect gastric accommodation or, at least, some stages of digestion., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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36. HLA-DPB1*13:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19.
- Author
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Farias TDJ, Brugiapaglia S, Croci S, Magistroni P, Curcio C, Zguro K, Fallerini C, Fava F, Pettini F, Kichula KM, Pollock NR, Font-Porterias N, Palmer WH, Marin WM, Baldassarri M, Bruttini M, Hollenbach JA, Hendricks AE, Meloni I, Novelli F, Renieri A, Furini S, Norman PJ, and Amoroso A
- Subjects
- Humans, SARS-CoV-2 genetics, Alleles, Receptors, KIR genetics, Genotype, Autoantibodies genetics, COVID-19 genetics, HLA-DP beta-Chains
- Abstract
Extreme polymorphism of HLA and killer-cell immunoglobulin-like receptors (KIR) differentiates immune responses across individuals. Additional to T cell receptor interactions, subsets of HLA class I act as ligands for inhibitory and activating KIR, allowing natural killer (NK) cells to detect and kill infected cells. We investigated the impact of HLA and KIR polymorphism on the severity of COVID-19. High resolution HLA class I and II and KIR genotypes were determined from 403 non-hospitalized and 1575 hospitalized SARS-CoV-2 infected patients from Italy collected in 2020. We observed that possession of the activating KIR2DS4*001 allotype is associated with severe disease, requiring hospitalization (OR = 1.48, 95% CI 1.20-1.85, p
c = 0.017), and this effect is greater in individuals homozygous for KIR2DS4*001 (OR = 3.74, 95% CI 1.75-9.29, pc = 0.003). We also observed the HLA class II allotype, HLA-DPB1*13:01 protects SARS-CoV-2 infected patients from severe disease (OR = 0.49, 95% CI 0.33-0.74, pc = 0.019). These association analyses were replicated using logistic regression with sex and age as covariates. Autoantibodies against IFN-α associated with COVID-19 severity were detected in 26% of 156 hospitalized patients tested. HLA-C*08:02 was more frequent in patients with IFN-α autoantibodies than those without, and KIR3DL1*01502 was only present in patients lacking IFN-α antibodies. These findings suggest that KIR and HLA polymorphism is integral in determining the clinical outcome following SARS-CoV-2 infection, by influencing the course both of innate and adaptive immunity., (© 2023 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons Ltd.)- Published
- 2024
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37. Early Steps in C-Type Inactivation of the hERG Potassium Channel.
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Pettini F, Domene C, and Furini S
- Subjects
- Potassium chemistry, Ether-A-Go-Go Potassium Channels chemistry, Ether-A-Go-Go Potassium Channels genetics, Molecular Dynamics Simulation
- Abstract
Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of paramount importance. At present, two models have been proposed to describe C-type inactivation in K
+ -channels. Experimental data and computational work on the bacterial KcsA channel support the hypothesis that C-type inactivation results from a closure of the selectivity filter that sterically impedes ion conduction. Alternatively, recent experimental structures of a mutated Shaker channel revealed a widening of the extracellular portion of the selectivity filter, which might diminish conductance by interfering with the mechanism of ion permeation. Here, we performed molecular dynamics simulations of the wild-type hERG, a non-inactivating mutant (hERG-N629D), and a mutant that inactivates faster than the wild-type channel (hERG-F627Y) to find out which and if any of the two reported C-type inactivation mechanisms applies to hERG. Closure events of the selectivity filter were not observed in any of the simulated trajectories but instead, the extracellular section of the selectivity filter deviated from the canonical conductive structure of potassium channels. The degree of widening of the potassium binding sites at the extracellular entrance of the channel was directly related to the degree of inactivation with hERG-F627Y > wild-type hERG > hERG-N629D. These findings support the hypothesis that C-type inactivation in hERG entails a widening of the extracellular entrance of the channel rather than a closure of the selectivity filter.- Published
- 2023
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38. Correlation between Diabetes Mellitus and Peri-implantitis: A Systematic Review.
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Dioguardi M, Cantore S, Quarta C, Sovereto D, Zerman N, Pettini F, Muzio LL, Cosola MD, Santacroce L, and Ballini A
- Subjects
- Humans, Inflammation, Glycemic Index, Peri-Implantitis epidemiology, Peri-Implantitis etiology, Peri-Implantitis therapy, Diabetes Mellitus epidemiology, Hyperglycemia
- Abstract
Background: Osseo-integrated implants provide effective treatment results for edentulous patients. However, despite the high success and survival rates of dental implants, several factors, such as poor oral hygiene and a history of periodontal disease, and systemic diseases, such as diabetes mellitus, could influence the outcome of the treatment. In fact, poor glycemic control can affect the healing process. Diabetes mellitus is considered a relative contraindication for dental implant therapy due to the fact that the success rates of the implants seem to be lower in diabetic patients, even if there is no total agreement among the results reported in the literature. The analysis of peri-implant inflammation indices, bone loss around the implant and glycemic index can provide us with useful information on the relationship between glycaemia in diabetic patients and the course of peri-implantitis, as well as implant success in the short term., Objective: The purpose of this review is to establish how peri-implant inflammation parameters vary in diabetic versus non-diabetic patients., Methods: This review was conducted on the basis of PRISMA. The search was conducted by three independent reviewers searching for keywords in three databases: PubMed, Scopus, Web Of Sciences (WOS), and the Cochrane Central Register of Controlled Trial., Results: A total of 1159 records were identified, and 11 articles were included in the qualitative analysis., Conclusion: The analysis of the extracted data from the included studies suggests that some periimplant inflammation indices, such as bleeding on probing and bone loss around the implant, appear to be increased in diabetic patients with glycometabolic decompensation, compared with control not affected by diabetes mellitus., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2023
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39. Bioinformatics Approaches to Predict Mutation Effects in the Binding Site of the Proangiogenic Molecule CD93.
- Author
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Cicaloni V, Karmakar M, Frusciante L, Pettini F, Visibelli A, Orlandini M, Galvagni F, Mongiat M, Silk M, Nardi F, Ascher D, Santucci A, and Spiga O
- Abstract
The transmembrane glycoprotein CD93 has been identified as a potential new target to inhibit tumor angiogenesis. Recently, Multimerin-2 (MMRN2), a pan-endothelial extracellular matrix protein, has been identified as a ligand for CD93, but the interaction mechanism between these two proteins is yet to be studied. In this article, we aim to investigate the structural and functional effects of induced mutations on the binding domain of CD93 to MMRN2. Starting from experimental data, we assessed how specific mutations in the C-type lectin-like domain (CTLD) affect the binding interaction profile. We described a four-step workflow in order to predict the effects of variations on the inter-residue interaction network at the PPI, based on evolutionary information, complex network metrics, and energetic affinity. We showed that the application of computational approaches, combined with experimental data, allowed us to gain more in-depth molecular insights into the CD93-MMRN2 interaction, offering a platform for developing innovative therapeutics able to target these molecules and block their interaction. This comprehensive molecular insight might prove useful in drug design in cancer therapy., Competing Interests: VC was employed by the company Toscana Life Sciences Foundation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Cicaloni, Karmakar, Frusciante, Pettini, Visibelli, Orlandini, Galvagni, Mongiat, Silk, Nardi, Ascher, Santucci and Spiga.)
- Published
- 2022
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40. Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease.
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Spiga O, Cicaloni V, Dimitri GM, Pettini F, Braconi D, Bernini A, and Santucci A
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- Alkaptonuria enzymology, Female, Homogentisate 1,2-Dioxygenase genetics, Humans, Male, Mutation, Rare Diseases, Alkaptonuria genetics, Databases, Genetic, Genotype, Machine Learning, Patient Selection, Precision Medicine
- Abstract
Alkaptonuria (AKU, OMIM: 203500) is an autosomal recessive disorder caused by mutations in the Homogentisate 1,2-dioxygenase (HGD) gene. A lack of standardized data, information and methodologies to assess disease severity and progression represents a common complication in ultra-rare disorders like AKU. This is the reason why we developed a comprehensive tool, called ApreciseKUre, able to collect AKU patients deriving data, to analyse the complex network among genotypic and phenotypic information and to get new insight in such multi-systemic disease. By taking advantage of the dataset, containing the highest number of AKU patient ever considered, it is possible to apply more sophisticated computational methods (such as machine learning) to achieve a first AKU patient stratification based on phenotypic and genotypic data in a typical precision medicine perspective. Thanks to our sufficiently populated and organized dataset, it is possible, for the first time, to extensively explore the phenotype-genotype relationships unknown so far. This proof of principle study for rare diseases confirms the importance of a dedicated database, allowing data management and analysis and can be used to tailor treatments for every patient in a more effective way., (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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41. Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans.
- Author
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Lazzerini PE, Cartocci A, Qu YS, Saponara S, Furini S, Fusi F, Fabris F, Gamberucci A, El-Sherif N, Cevenini G, Pettini F, Laghi-Pasini F, Acampa M, Bertolozzi I, Capecchi PL, Lazaro D, and Boutjdir M
- Subjects
- Cells, Cultured, Female, Humans, Incidence, Long QT Syndrome physiopathology, Male, Middle Aged, Treatment Outcome, United States epidemiology, ERG1 Potassium Channel metabolism, Electrocardiography, Long QT Syndrome drug therapy, Proton Pump Inhibitors therapeutic use, Veterans
- Abstract
[Figure: see text].
- Published
- 2021
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42. Multi-Omics Model Applied to Cancer Genetics.
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Pettini F, Visibelli A, Cicaloni V, Iovinelli D, and Spiga O
- Subjects
- Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic immunology, Cell Transformation, Neoplastic metabolism, Chromosome Aberrations, Computational Biology methods, Disease Susceptibility, Genetic Predisposition to Disease, Humans, Machine Learning, Precision Medicine, Proteomics methods, Transcriptome, Epigenomics methods, Genomics methods, Neoplasms etiology
- Abstract
In this review, we focus on bioinformatic oncology as an integrative discipline that incorporates knowledge from the mathematical, physical, and computational fields to further the biomedical understanding of cancer. Before providing a deeper insight into the bioinformatics approach and utilities involved in oncology, we must understand what is a system biology framework and the genetic connection, because of the high heterogenicity of the backgrounds of people approaching precision medicine. In fact, it is essential to providing general theoretical information on genomics, epigenomics, and transcriptomics to understand the phases of multi-omics approach. We consider how to create a multi-omics model. In the last section, we describe the new frontiers and future perspectives of this field.
- Published
- 2021
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43. Correlation between occlusal trauma and oral microbiota: a microbiological investigation.
- Author
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Inchingolo AD, Di Cosola M, Inchingolo AM, Greco Lucchina A, Malcangi G, Pettini F, Scarano A, Bordea IR, Hazballa D, Lorusso F, Inchingolo F, and Dipalma G
- Subjects
- Humans, Periodontium, Dental Occlusion, Traumatic, Microbiota, Periodontal Diseases, Periodontitis
- Abstract
The occlusal trauma has been defined as an injury to the periodontium resulting from occlusal forces that exceeds the reparative capacity of the attachment apparatus. Currently, the effects of occlusal trauma on tooth support tissues, the onset and the progression of periodontal disease are still debated. In fact, researchers started evaluating the possible effects of occlusal discrepancies on incidence, progression, and treatment outcomes of periodontitis, but all the results underlined the more significant role played by microbiological flora. The results of this study show that after 60 days of treating the occlusal trauma, a significant reduction was achieved in the periodontal bacterial flora., (Copyright 2020 Biolife Sas. www.biolifesas.org.)
- Published
- 2021
- Full Text
- View/download PDF
44. Gender medicine: the impact of probiotics on male patients.
- Author
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Pacifici L, Santacroce L, Dipalma G, Haxhirexha K, Topi S, Cantore S, Altini V, Pacifici A, De Vito D, Pettini F, Cascella G, Saini R, Scacco S, Ballini A, and Inchingolo F
- Subjects
- Aged, Double-Blind Method, Humans, Male, Men's Health, Middle Aged, Pilot Projects, Enterococcus faecalis isolation & purification, Escherichia coli isolation & purification, Probiotics therapeutic use, Prostatitis drug therapy, Prostatitis urine
- Abstract
Purpose: Numerous studies in the literature confirm the importance of the use of probiotics in inflammatory states of the prostate in humans. Our pilot study aimed to test probiotics strains ability to improve urinary bacterial load in male subjects., Methods: Twenty healthy men aged 55-65 years, with recurrent urinatory infections were enrolled and randomized into 2 groups. Urine culturing to detect Enterobacteriaceae (Escherichia Coli and Enterococcus faecalis) was performed at baseline and at 12 weeks after the starting of the study., Results: We found that taking the probiotic reduces the bacterial load of E. coli and E. faecalis in urine cultures. The use of the probiotic in these inflammatory states does not affect the change in weight in the tested subjects., Conclusions: Our data confirm and improve the main results reported in the scientific literature on the importance of taking probiotics in prostatitis.
- Published
- 2021
- Full Text
- View/download PDF
45. The pivotal role of oral microbiota in health and disease.
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Santacroce L, Sardaro N, Topi S, Pettini F, Bottalico L, Cantore S, Cascella G, Del Prete R, Dipalma G, and Inchingolo F
- Subjects
- Microbiota, Probiotics
- Published
- 2020
- Full Text
- View/download PDF
46. Effects of sea salt rinses on subjects undergone to oral surgery: a single blinded randomized controlled trial.
- Author
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Cantore S, Ballini A, Saini R, Altini V, De Vito D, Pettini F, Dipalma G, and Inchingolo F
- Subjects
- Adult, Female, Humans, Italy, Male, Middle Aged, Mouthwashes pharmacology, Oral Surgical Procedures, Single-Blind Method, Sodium Chloride pharmacology, Edema drug therapy, Inflammation drug therapy, Mouthwashes therapeutic use, Muramidase therapeutic use, Seawater, Sodium Chloride therapeutic use, Wound Healing drug effects, Xylitol therapeutic use
- Abstract
Purpose: It has been customary to explain the dentally beneficial effects of xylitol and certain other natural compound as lysozyme and seas salt in terms of microbiological effects only. Several studies have tested the use of natural ingredients, alcohol and fluoride free, in mouthwashes. The purpose of this study was to evaluate a combined mouthwash formulation containing natural antibiofilm agents in oral care wound healing after routinely oral surgery (extraction) procedures., Methods: Patients were assigned following a blinded randomized controlled trial and divided into two groups, an experimental group (I = 15) and a control (placebo) group (II = 15). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated at ten and thirty days after extraction procedure. Pain and swelling were evaluated using the well-known visual analogue scale (VAS) scale throughout study period following extraction. The mean difference in Pre and Post values were compared among the groups. The change in pre-post score was analyzed using the paired t test., Results: An appreciable wound healing was seen in the experimental group when compared to the control sites, with no reported adverse effects. Four weeks postoperative patient's satisfaction level, to subjective and objective outcome measurements in documenting the result of a mouthwash treatment showed an interesting difference between groups., Conclusions: Since combined mouthwash formulations, containing natural/bioactive substances, could provide a cheap, safe and acceptable alternative in oral care, further studies will also be required to study these effects and their mechanism of action in detail.
- Published
- 2020
- Full Text
- View/download PDF
47. Effect of activated charcoal probiotic toothpaste containing Lactobacillus paracasei and xylitol on dental caries: a randomized and controlled clinical trial.
- Author
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Ballini A, Cantore S, Saini R, Pettini F, Fotopoulou EA, Saini SR, Georgakopoulos IP, Dipalma G, Gargiulo Isacco C, and Inchingolo F
- Subjects
- Humans, Charcoal therapeutic use, Dental Caries prevention & control, Lacticaseibacillus paracasei, Probiotics, Toothpastes chemistry, Xylitol
- Published
- 2019
48. Applications of in Silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions.
- Author
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Cicaloni V, Trezza A, Pettini F, and Spiga O
- Subjects
- Animals, Humans, Models, Chemical, Protein Binding, Computer Simulation, Drug Delivery Systems, Drug Discovery, Protein Interaction Domains and Motifs drug effects, Proteins chemistry
- Abstract
Background: Identification of Protein-Protein Interactions (PPIs) is a major challenge in modern molecular biology and biochemistry research, due to the unquestionable role of proteins in cells, biological process and pathological states. Over the past decade, the PPIs have evolved from being considered a highly challenging field of research to being investigated and examined as targets for pharmacological intervention., Objective: Comprehension of protein interactions is crucial to known how proteins come together to build signalling pathways, to carry out their functions, or to cause diseases, when deregulated. Multiplicity and great amount of PPIs structures offer a huge number of new and potential targets for the treatment of different diseases., Methods: Computational techniques are becoming predominant in PPIs studies for their effectiveness, flexibility, accuracy and cost. As a matter of fact, there are effective in silico approaches which are able to identify PPIs and PPI site. Such methods for computational target prediction have been developed through molecular descriptors and data-mining procedures., Results: In this review, we present different types of interactions between protein-protein and the application of in silico methods for design and development of drugs targeting PPIs. We described computational approaches for the identification of possible targets on protein surface and to detect of stimulator/ inhibitor molecules., Conclusion: A deeper study of the most recent bioinformatics methodologies for PPIs studies is vital for a better understanding of protein complexes and for discover new potential PPI modulators in therapeutic intervention., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2019
- Full Text
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49. Structural investigation of Rett-inducing MeCP2 mutations.
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Spiga O, Gardini S, Rossi N, Cicaloni V, Pettini F, Niccolai N, and Santucci A
- Abstract
X-ray structure of methyl-CpG binding domain (MBD) of MeCP2, an intrinsically disordered protein (IDP) involved in Rett syndrome, offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett syndrome, RTT, occur. We have ascribed pathogenicity for mutations of amino acids bearing positively charged side chains, all located at the protein-DNA interface, as positive charge removal cause reduction of the MeCP2-DNA adduct lifetime. Pathogenicity of the frequent proline replacements, outside the DNA contact moiety of MBD, can be attributed to the role of this amino acid for maintaining both unfolded states for unbound MeCP2 and, at the same time, to favor some higher conformational order for stabilizing structural determinants required by protein activity. These hypotheses can be extended to transcription repressor domain, TRD, the other MeCP2-DNA interaction site and, in general, to all the IDP that interact with nucleic acids.
- Published
- 2018
- Full Text
- View/download PDF
50. Maxillary Overdenture Retained with an Implant Support CAD-CAM Bar: A 4 Years Follow Up Case.
- Author
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Corsalini M, Di Venere D, Stefanachi G, Muci G, Palminteri A, Laforgia A, and Pettini F
- Abstract
Introduction: Oral rehabilitation with overdenture on implants of upper jaw must be taken into consideration a variety of anatomical and biomechanical issues. It is possible to provide for rehabilitation with two or more implants, in different positions, solidarizing them with a bar., Materials & Methods: The present study involved a patient rehabilitated with 4 Xive implants (Friadent GmbH, Mannheim, Germany) solidarized with a titanium bar crafted with CAD-CAM technology for maximal comfort, precision and structural lightness., Results & Discussion: The follow-up was 54 months, with an implant survival of 100%. Based on our clinical evidence, bars engineered with CAD-CAM technology are promising in terms of precision and comfort despite higher costs.
- Published
- 2017
- Full Text
- View/download PDF
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