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Your search keyword '"Pfeiffer, Pauline"' showing total 13 results
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13 results on '"Pfeiffer, Pauline"'

1. An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma

Author

Flümann, Ruth, Hansen, Julia, Meinel, Jörn, Pfeiffer, Pauline, Goldfarb Wittkopf, Hannah, Lütz, Anna, Wirtz, Jessica, Möllmann, Michael, Zhou, Tanja, Tabatabai, Areya, Lohmann, Tim, Jauch, Maximilian, Beleggia, Filippo, Pelzer, Benedikt, Ullrich, Fabian, Höfmann, Svenja, Arora, Aastha, Persigehl, Thorsten, Büttner, Reinhard, von Tresckow, Bastian, Klein, Sebastian, Jachimowicz, Ron D., Reinhardt, Hans Christian, and Knittel, Gero

Published
2024
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2. Dose-efficient in vivo X-ray phase contrast imaging at micrometer resolution

Author

Spiecker, Rebecca, primary, Pfeiffer, Pauline, additional, Biswal, Adyasha, additional, Shcherbinin, Mykola, additional, Spiecker, Martin, additional, Hessdorfer, Holger, additional, Hurst, Mathias, additional, Zharov, Yaroslav, additional, Bellucci, Valerio, additional, Farago, Tomas, additional, Zuber, Marcus, additional, Herz, Annette, additional, Cecilia, Angelica, additional, Czyzycki, Mateusz, additional, Dias, Carlos, additional, Novikov, Dmitri, additional, Krogmann, Lars, additional, Hamann, Elias, additional, van de Kamp, Thomas, additional, and Baumbach, Tilo, additional

Published
2023
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3. Table S3 from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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4. Data from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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5. Supplementary Data from An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, primary, Nieper, Pascal, primary, Pfeiffer, Pauline, primary, Holzem, Alessandra, primary, Klein, Sebastian, primary, Bhatia, Sanil, primary, Kochanek, Moritz, primary, Kisis, Ilmars, primary, Pelzer, Benedikt W., primary, Ahlert, Heinz, primary, Hauer, Julia, primary, da Palma Guerreiro, Alexandra, primary, Ryan, Jeremy A., primary, Reimann, Maurice, primary, Riabinska, Arina, primary, Wiederstein, Janica, primary, Krüger, Marcus, primary, Deckert, Martina, primary, Altmüller, Janine, primary, Klatt, Andreas R., primary, Frenzel, Lukas P., primary, Pasqualucci, Laura, primary, Béguelin, Wendy, primary, Melnick, Ari M., primary, Sander, Sandrine, primary, Montesinos-Rongen, Manuel, primary, Brunn, Anna, primary, Lohneis, Philipp, primary, Büttner, Reinhard, primary, Kashkar, Hamid, primary, Borkhardt, Arndt, primary, Letai, Anthony, primary, Persigehl, Thorsten, primary, Peifer, Martin, primary, Schmitt, Clemens A., primary, Reinhardt, Hans Christian, primary, and Knittel, Gero, primary

Published
2023
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8. An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

Author

Flümann, Ruth, primary, Rehkämper, Tim, additional, Nieper, Pascal, additional, Pfeiffer, Pauline, additional, Holzem, Alessandra, additional, Klein, Sebastian, additional, Bhatia, Sanil, additional, Kochanek, Moritz, additional, Kisis, Ilmars, additional, Pelzer, Benedikt W., additional, Ahlert, Heinz, additional, Hauer, Julia, additional, da Palma Guerreiro, Alexandra, additional, Ryan, Jeremy A., additional, Reimann, Maurice, additional, Riabinska, Arina, additional, Wiederstein, Janica, additional, Krüger, Marcus, additional, Deckert, Martina, additional, Altmüller, Janine, additional, Klatt, Andreas R., additional, Frenzel, Lukas P., additional, Pasqualucci, Laura, additional, Béguelin, Wendy, additional, Melnick, Ari M., additional, Sander, Sandrine, additional, Montesinos-Rongen, Manuel, additional, Brunn, Anna, additional, Lohneis, Philipp, additional, Büttner, Reinhard, additional, Kashkar, Hamid, additional, Borkhardt, Arndt, additional, Letai, Anthony, additional, Persigehl, Thorsten, additional, Peifer, Martin, additional, Schmitt, Clemens A., additional, Reinhardt, Hans Christian, additional, and Knittel, Gero, additional

Published
2021
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9. Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor

Author

Wypijewska del Nogal, Anna, primary, Füchtbauer, Anders F, additional, Bood, Mattias, additional, Nilsson, Jesper R, additional, Wranne, Moa S, additional, Sarangamath, Sangamesh, additional, Pfeiffer, Pauline, additional, Rajan, Vinoth Sundar, additional, El-Sagheer, Afaf H, additional, Dahlén, Anders, additional, Brown, Tom, additional, Grøtli, Morten, additional, and Wilhelmsson, L Marcus, additional

Published
2020
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10. Interbase FRET in RNA: from A to Z

Author

Füchtbauer, Anders F, primary, Wranne, Moa S, additional, Bood, Mattias, additional, Weis, Erik, additional, Pfeiffer, Pauline, additional, Nilsson, Jesper R, additional, Dahlén, Anders, additional, Grøtli, Morten, additional, and Wilhelmsson, L Marcus, additional

Published
2019
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11. An In VivoPiggyBacInsertional Mutagenesis Screen Reveals Oncogenic Lesions Cooperating with Myd88 L265P

Author

Höfmann, Svenja, Flümann, Ruth, Hansen, Julia, Klein, Sebastian, Meinel, Jörn, Pfeiffer, Pauline, Goldfarb-Wittkopf, Hannah, Lütz, Anna, Wirtz, Jessica, Möllmann, Michael, Zhou, Tanja, Tabatabai, Areya, Lohmann, Tim, Beleggia, Filippo, Pelzer, Benedikt, Ullrich, Fabian, Arora, Aastha, Persigehl, Thorsten, Büttner, Reinhard, von Tresckow, Bastian, Jachimowicz, Ron, Knittel, Gero, and Reinhardt, Hans Christian

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common Non-Hodgkin lymphoma and originates from transformed germinal center-experienced B cells. Traditionally, DLBCL has been divided into two subtypes, depending on whether the transcriptional profile of the tumor relates to an activated B cell or a germinal center B cell (ABC and GCB DLBCL, Alizadeh et al., 2000). More recent efforts classified DLBCL cases based on their genetic aberrations and identified several clusters with distinct mutational profiles (Chapuy et al., 2018, Schmitz et al., 2018, Wright et al., 2020). The MCD/C5 cluster is characterized by recurrent mutations in MYD88, PRDM1and frequent amplifications of BCL2, amongst others. We recently showed that mice harboring a B cell-specific Myd88 L252Pmutation (orthologous position of the human p.L265P mutation) develop B cell proliferation and occasional transformation into DLBCL (Knittel et al., 2016). Lymphomagenesis is further increased when Myd88 L252Pis combined with BCL2overexpression and a genetically engineered block in plasmacytic differentiation by loss of Prdm1or overexpression of Spib(Flümann et al., 2021).

Published
2023
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12. An inducible Cd79bmutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma

Author

Flümann, Ruth, Hansen, Julia, Meinel, Jörn, Pfeiffer, Pauline, Wittkopf, Hannah Goldfarb, Lütz, Anna, Wirtz, Jessica, Möllmann, Michael, Zhou, Tanja, Tabatabai, Areya, Lohmann, Tim, Jauch, Maximilian, Beleggia, Filippo, Pelzer, Benedikt, Ullrich, Fabian, Höfmann, Svenja, Arora, Aastha, Persigehl, Thorsten, Büttner, Reinhard, von Tresckow, Bastian, Klein, Sebastian, Jachimowicz, Ron D., Reinhardt, Hans Christian, and Knittel, Gero

Abstract

•In mouse models of Myd88-driven DLBCL, the presence of a Cd79bITAM mutation results in increased B-cell receptor proximal signaling.•The increased B-cell receptor signaling activity in Cd79b-mutated models confers a selective ibrutinib sensitivity.

Published
2023
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13. Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleoside phosphate analogues.

Author

Pfeiffer P, Nilsson JR, Gallud A, Baladi T, Le HN, Bood M, Lemurell M, Dahlén A, Grøtli M, Esbjörner EK, and Wilhelmsson LM

Abstract

RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probing and understanding their dynamics in cells is important. Fluorescence microscopy offers live-cell spatiotemporal monitoring but requires labels. We present two fluorescent adenine analogue nucleoside phosphates which show spontaneous uptake and accumulation in cultured human cells, likely via nucleoside transporters, and show their potential utilization as cellular RNA labels. Upon uptake, one nucleotide analogue, 2CNqAXP, localizes to the cytosol and the nucleus. We show that it could then be incorporated into de novo synthesized cellular RNA, i.e. it was possible to achieve metabolic fluorescence RNA labeling without using genetic engineering to enhance incorporation, uptake-promoting strategies, or post-labeling through bio-orthogonal chemistries. By contrast, another nucleotide analogue, pAXP, only accumulated outside of the nucleus and was rapidly excreted. Consequently, this analogue did not incorporate into RNA. This difference in subcellular accumulation and retention results from a minor change in nucleobase chemical structure. This demonstrates the importance of careful design of nucleoside-based drugs, e.g. antivirals to direct their subcellular localization, and shows the potential of fine-tuning fluorescent base analogue structures to enhance the understanding of the function of such drugs., (© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2024
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