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183 results on '"Pham-Thi, Nhân"'

1. MASK-air: An OECD (Organisation for Economic Co-operation and Development) Best Practice for Public Health on Integrated Care for Chronic Diseases

Author: Czarlewski, Wienczyslawa, Haahtela, Tari, Canonica, G. Walter, Costa, Elisio M., Klimek, Ludger, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Kulus, Marek, Larenas-Linnemann, Désirée E., Louis, Renaud, Pfaar, Oliver, Papadopoulos, Nikolaos G., Pham-Thi, Nhân, Regateiro, Frederico S., Roche, Nicolas, Samolinski, Boleslaw, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Valiulis, Arunas, Yorgancioglu, Arzu, Ventura, Maria Teresa, Almeida, Rute, Amaral, Rita, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Brussino, Luisa, Cardona, Victoria, Cecchi, Lorenzo, Loureiro, Claudia Chaves, Cingi, Cemal, Cruz, Alvaro A., Fokkens, Wytske J., de Vries, Govert, Gemicioglu, Bilun, Giuliano, Antonio F.M., Linuma, Tomohisa, Ivancevich, Juan Carlos, Jácome, Cristina, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Gilles, Lourenço, Olga, Makela, Mika, Makris, Michael, Morais-Almeida, Mario, Mösges, Ralph, Maurer, Marcus, Mullol, Joaquim, Nadif, Rachel, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Ollert, Markus, Olze, Heidi, Patella, Vincenzo, Pétré, Benoit, Puggioni, Francesca, Romantowski, Jan, Rouadi, Philip W., Reitsma, Sietze, Rivero-Yeverino, Daniela, Rodriguez-Gonzalez, Monica, Sá-Sousa, Ana, Savouré, Marine, Serpa, Faradiba S., Shamji, Mohamed H., Sheikh, Aziz, Ulrik, Charlotte Suppli, Sofiev, Mikhail, Sova, Milan, Sperl, Annette, Todo-Bom, Ana, Tomazic, Peter V., Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, van Eerd, Michiel, Zidarn, Mihaela, Blain, Hubert, Boulet, Louis-Philippe, Brusselle, Guy, Buhl, Roland, Charpin, Denis, Casale, Thomas, Chivato, Tomas, Correia-de-Sousa, Jaime, Corrigan, Christopher, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Dykewicz, Mark, Fiocchi, Alessandro, Giovannini, Mattia, Jassem, Ewa, Jutel, Marek, Keil, Thomas, La Grutta, Stefania, Lipworth, Brian, Papi, Alberto, Pépin, Jean-Louis, Quirce, Santiago, Cordeiro, Carlos Robalo, Torres, Maria J., Usmani, Omar S., Bousquet, Jean, Sousa-Pinto, Bernardo, Anto, Josep M., Bedbrook, Anna, Fonseca, Joao A., and Zuberbier, Torsten
Published: 2024
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2. PR-CIM: a Variation-Aware Binary-Neural-Network Framework for Process-Resilient Computation-in-memory

Author: Le, Minh-Son, Pham, Thi-Nhan, Nguyen, Thanh-Dat, and Chang, Ik-Joon
Subjects: Computer Science - Machine Learning
Abstract: Binary neural networks (BNNs) that use 1-bit weights and activations have garnered interest as extreme quantization provides low power dissipation. By implementing BNNs as computing-in-memory (CIM), which computes multiplication and accumulations on memory arrays in an analog fashion, namely analog CIM, we can further improve the energy efficiency to process neural networks. However, analog CIMs suffer from the potential problem that process variation degrades the accuracy of BNNs. Our Monte-Carlo simulations show that in an SRAM-based analog CIM of VGG-9, the classification accuracy of CIFAR-10 is degraded even below 20% under process variations of 65nm CMOS. To overcome this problem, we present a variation-aware BNN framework. The proposed framework is developed for SRAM-based BNN CIMs since SRAM is most widely used as on-chip memory, however easily extensible to BNN CIMs based on other memories. Our extensive experimental results show that under process variation of 65nm CMOS, our framework significantly improves the CIFAR-10 accuracies of SRAM-based BNN CIMs, from 10% and 10.1% to 87.76% and 77.74% for VGG-9 and RESNET-18 respectively., Comment: 8 pages, 11 figures
Published: 2021

3. Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study

Author: Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Canonica, G. Walter, Costa, Elisio M., Kupczyk, Maciej, Kvedariene, Violeta, Kulus, Marek, Larenas-Linnemann, Désirée E., Pfaar, Oliver, Papadopoulos, Nikolaos G., Pham-Thi, Nhân, Regateiro, Frederico S., Roche, Nicolas, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Valiulis, Arunas, Yorgancioglu, Arzu, Ventura, Maria Teresa, Almeida, Rute, Amaral, Rita, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Brussino, Luisa, Cardona, Victoria, Cecchi, Lorenzo, Loureiro, Claudia Chaves, Cingi, Cemal, Cruz, Alvaro A., Fokkens, Wytske J., de Vries, Govert, Gemicioglu, Bilun, Giuliana, Antonio F.M., Linuma, Tomohisa, Ivancevich, Juan Carlos, Jácome, Cristina, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Gilles, Lourenço, Olga, Makela, Mika, Makris, Michael, Mösges, Ralph, Maurer, Marcus, Mullol, Joaquim, Nadif, Rachel, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Ollert, Markus, Olze, Heidi, Patella, Vincenzo, Pétré, Benoit, Puggioni, Francesca, Romantowski, Jan, Rouadi, Philip W., Reitsma, Sietze, Rivero-Yeverino, Daniela, Rodriguez-Gonzalez, Monica, Sá-Sousa, Ana, Serpa, Faradiba S., Shamji, Mohamed H., Sheikh, Aziz, Ulrik, Charlotte Suppli, Sofiev, Mikhail, Sova, Milan, Sperl, Annette, Todo-Bom, Ana, Tomazic, Peter V., Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, van Eerd, Michiel, Zidarn, Mihaela, Blain, Hubert, Boulet, Louis-Philippe, Brusselle, Guy, Buhl, Roland, Charpin, Denis, Casale, Thomas, Chivato, Tomas, Correia-de-Sousa, Jaime, Corrigan, Christopher, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Dykewicz, Mark, Fiocchi, Alessandro, Giovannini, Mattia, Jassem, Ewa, Jutel, Marek, Keil, Thomas, La Grutta, Stefania, Lipworth, Brian, Papi, Alberto, Pépin, Jean-Louis, Quirce, Santiago, Cordeiro, Carlos Robalo, Torres, Maria J., Usmani, Omar S., Vieira, Rafael José, Leemann, Lucas, Briggs, Andrew, Pereira, Ana Margarida, Savouré, Marine, Kuna, Piotr, Morais-Almeida, Mário, Bewick, Michael, Azevedo, Luís Filipe, Louis, Renaud, Klimek, Ludger, Bahbah, Farah, Samolinski, Boleslaw, Anto, Josep M., Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
Published: 2024
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4. Self-sensing characteristics of smart high-performance cementitious composites containing multiwall carbon nanotubes, steel fibers, and steel slag aggregates under compression

Author: Le, Huy Viet, Nguyen, Van Manh, Pham, Thi Nhan, Tang, Van Lam, Pham, Xuan Nui, Nguyen, Duy Liem, and Kim, Dong Joo
Published: 2024
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5. Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study

Author: Sousa-Pinto, Bernardo, Louis, Gilles, Rodrigues, Jorge, Giuliano, Antonio Francesco Maria, Baiardini, Ilaria, Braido, Fulvio, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Valiulis, Arunas, Brussino, Luisa, Cecchi, Lorenzo, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Klimek, Ludger, Kraxner, Helga, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Désirée, Louis, Renaud, Nadif, Rachel, Niedoszytko, Marek, Okamoto, Yoshitaka, Ollert, Markus, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pfaar, Oliver, Regateiro, Frederico S., Roche, Nicolas, Rouadi, Philip W., Samolinski, Boleslaw, Sastre, Joaquin, Savouré, Marine, Scichilone, Nicola, Sheikh, Aziz, Taborda-Barata, Luís, Toppila-Salmi, Sanna, Yorgancioglu, Arzu, Zidarn, Mihaela, Anto, Josep M., Zuberbier, Torsten, Canonica, G. Walter, Ventura, Maria Teresa, Fonseca, João A., Pétré, Benoit, and Bousquet, Jean
Published: 2023
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6. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study

Author: Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S, Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H, Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G Walter, Cruz, Alvaro A, Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C, Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Luna Pech, Jorge, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E, Ohta, Ken, Papadopoulos, Nikolaos G, Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S, Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M, Fonseca, João A, and Bousquet, Jean
Published: 2023
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7. Cutoff Values of MASK-air Patient-Reported Outcome Measures

Author: Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Pereira, Ana Margarida, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chivato, Tomas, Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Laune, Daniel, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
Published: 2023
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8. Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants

Author: Chauvin, Camille, Levillayer, Laurine, Roumier, Mathilde, Nielly, Hubert, Roth, Claude, Karnam, Anupama, Bonam, Srinivasa Reddy, Bourgarit, Anne, Dubost, Clément, Bousquet, Aurore, Le Burel, Sébastien, Mestiri, Raphaële, Sene, Damien, Galland, Joris, Vasse, Marc, Groh, Matthieu, Le Marchand, Mathilde, Vassord-Dang, Camille, Gautier, Jean-François, Pham-Thi, Nhan, Verny, Christiane, Pitard, Bruno, Planchais, Cyril, Mouquet, Hugo, Paul, Richard, Simon-Loriere, Etienne, Bayry, Jagadeesh, Gilardin, Laurent, and Sakuntabhai, Anavaj
Published: 2023
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9. Academic Productivity of Young People With Allergic Rhinitis: A MASK-air Study

Author: Vieira, Rafael José, Pham-Thi, Nhân, Anto, Josep M., Czarlewski, Wienczyslawa, Sá-Sousa, Ana, Amaral, Rita, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cecchi, Lorenzo, Cruz, Alvaro A., Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Désirée, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pfaar, Oliver, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Ventura, Maria Teresa, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João A., Bousquet, Jean, and Sousa-Pinto, Bernardo
Published: 2022
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10. The Allergic Rhinitis and Its Impact on Asthma (ARIA) Approach of Value-Added Medicines: As-Needed Treatment in Allergic Rhinitis

Author: Bousquet, Jean, Toumi, Mondher, Sousa-Pinto, Bernardo, Anto, Josep M., Bedbrook, Anna, Czarlewski, Wienczyslawa, Valiulis, Arunas, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cecchi, Lorenzo, Cherrez-Ojeda, Ivan, Chivato, Tomas, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Fonseca, Joao A., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Jutel, Marek, Kaidashev, Igor, Klimek, Ludger, Kvedariene, Violeta, Kuna, Piotr, Larenas-Linnemann, Désirée E., Lipworth, Brian, Morais-Almeida, Mario, Mullol, Joaquim, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Taborda-Barata, Luis, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zidarn, Mihaela, and Zuberbier, Torsten
Published: 2022
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11. Plastic scintillators with 1-phenyl-3-(mesityl)-2-pyrazoline as unique fluorophore for efficient neutron/gamma pulse shape discrimination

Author: Bisaro, Fabrice, Inial, Alya, Gatignol, Jérémie, Allix, Florent, Stallivieri, Aurélie, Renaud, Jean-Luc, Achouri, Lynda, Parlog, Marian, Delaunay, Franck, Pham, Thi-Nhàn, Hamel, Matthieu, and Gaillard, Sylvain
Published: 2022
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12. Fracture and deformation behaviors of saturated and dried single-edge notched beam sandstones under three-point bending based on DIC

Author: Qin, Xiaofeng, Su, Haijian, Feng, Yujie, Zhao, Honghui, and Pham, Thi Nhan
Published: 2022
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13. Poor rhinitis and asthma control is associated with decreased health-related quality-of-life and utilities: A MASK-air study

Author: Vieira, Rafael José, primary, Leemann, Lucas, additional, Briggs, Andrew, additional, Pereira, Ana Margarida, additional, Savouré, Marine, additional, Kuna, Piotr, additional, Morais-Almeida, Mário, additional, Bewick, Michael, additional, Azevedo, Luís Filipe, additional, Louis, Renaud, additional, Klimek, Ludger, additional, Bahbah, Farah, additional, Samolinski, Boleslaw, additional, Anto, Josep M., additional, Zuberbier, Torsten, additional, Fonseca, João A., additional, Bousquet, Jean, additional, Sousa-Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Canonica, G Walter, additional, Costa, Elisio M., additional, Kupczyk, Maciej, additional, Kvedariene, Violeta, additional, Kulus, Marek, additional, Larenas-Linnemann, Désirée E., additional, Pfaar, Oliver, additional, Papadopoulos, Nikolaos G., additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Roche, Nicolas, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Taborda-Barata, Luis, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Ventura, Maria Teresa, additional, Almeida, Rute, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic-Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Loureiro, Claudia Chaves, additional, Cingi, Cemal, additional, Cruz, Alvaro A., additional, Fokkens, Wytske J., additional, de Vries, Govert, additional, Gemicioglu, Bilun, additional, Giuliana, Antonio FM., additional, Linuma, Tomohisa, additional, Ivancevich, Juan Carlos, additional, Jácome, Cristina, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Gilles, additional, Lourenço, Olga, additional, Makela, Mika, additional, Makris, Michael, additional, Mösges, Ralph, additional, Maurer, Marcus, additional, Mullol, Joaquim, additional, Nadif, Rachel, additional, Niedoszytko, Marek, additional, O’Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Olze, Heidi, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Puggioni, Francesca, additional, Romantowski, Jan, additional, Rouadi, Philip W., additional, Reitsma, Sietze, additional, Rivero-Yeverino, Daniela, additional, Rodriguez-Gonzalez, Monica, additional, Sá-Sousa, Ana, additional, Serpa, Faradiba S., additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Sofiev, Mikhail, additional, Sova, Milan, additional, Sperl, Annette, additional, Todo-Bom, Ana, additional, Tomazic, Peter V., additional, Toppila-Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, van Eerd, Michiel, additional, Zidarn, Mihaela, additional, Blain, Hubert, additional, Boulet, Louis-Philippe, additional, Brusselle, Guy, additional, Buhl, Roland, additional, Charpin, Denis, additional, Casale, Thomas, additional, Chivato, Tomas, additional, Correia-de-Sousa, Jaime, additional, Corrigan, Christopher, additional, de Blay, Frédéric, additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Dykewicz, Mark, additional, Fiocchi, Alessandro, additional, Giovannini, Mattia, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, La Grutta, Stefania, additional, Lipworth, Brian, additional, Papi, Alberto, additional, Pépin, Jean-Louis, additional, Quirce, Santiago, additional, Cordeiro, Carlos Robalo, additional, Torres, Maria J., additional, and Usmani, Omar S., additional
Published: 2024
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14. MASK-air®: An OECD (Organisation for Economic Coordination and Development) Best Practice for Public Health on integrated care for chronic diseases.

Author: Bousquet, Jean, primary, Sousa-Pinto, Bernardo, additional, Anto, Josep M., additional, Bedbrook, Anna, additional, Fonseca, Joao A., additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Haahtela, Tari, additional, Canonica, G Walter, additional, Costa, Elisio M., additional, Klimek, Ludger, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Kvedariene, Violeta, additional, Kulus, Marek, additional, Larenas-Linnemann, Désirée E., additional, Louis, Renaud, additional, Pfaar, Oliver, additional, Papadopoulos, Nikolaos G., additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Roche, Nicolas, additional, Samolinski, Boleslaw, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Taborda-Barata, Luis, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Ventura, Maria Teresa, additional, Almeida, Rute, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic-Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Loureiro, Claudia Chaves, additional, Cingi, Cemal, additional, Cruz, Alvaro A., additional, Fokkens, Wytske J., additional, de Vries, Govert, additional, Gemicioglu, Bilun, additional, Giuliano, Antonio FM., additional, Linuma, Tomohisa, additional, Ivancevich, Juan Carlos, additional, Jácome, Cristina, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Gilles, additional, Lourenço, Olga, additional, Makela, Mika, additional, Makris, Michael, additional, Morais-Almeida, Mario, additional, Mösges, Ralph, additional, Maurer, Marcus, additional, Mullol, Joaquim, additional, Nadif, Rachel, additional, Niedoszytko, Marek, additional, O’Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Ollert, Markus, additional, Olze, Heidi, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Puggioni, Francesca, additional, Romantowski, Jan, additional, Rouadi, Philip W., additional, Reitsma, Sietze, additional, Rivero-Yeverino, Daniela, additional, Rodriguez-Gonzalez, Monica, additional, Sá-Sousa, Ana, additional, Savouré, Marine, additional, Serpa, Faradiba S., additional, Shamji, Mohamed H., additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Sofiev, Mikhail, additional, Sova, Milan, additional, Sperl, Annette, additional, Todo-Bom, Ana, additional, Tomazic, Peter V., additional, Toppila-Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, van Eerd, Michiel, additional, Zidarn, Mihaela, additional, Blain, Hubert, additional, Boulet, Louis-Philippe, additional, Brusselle, Guy, additional, Buhl, Roland, additional, Charpin, Denis, additional, Casale, Thomas, additional, Chivato, Tomas, additional, Correia-de-Sousa, Jaime, additional, Corrigan, Christopher, additional, de Blay, Frédéric, additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Dykewicz, Mark, additional, Fiocchi, Alessandro, additional, Giovannini, Mattia, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, La Grutta, Stefania, additional, Lipworth, Brian, additional, Papi, Alberto, additional, Pépin, Jean-Louis, additional, Quirce, Santiago, additional, Cordeiro, Carlos Robalo, additional, Torres, Maria J., additional, and Usmani, Omar S., additional
Published: 2024
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15. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis:A MASK-air study

Author: Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, Ulrik, Charlotte Suppli, Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, and Ulrik, Charlotte Suppli
Abstract: Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control., Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Published: 2024

16. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study.

Author: Sousa‐Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá‐Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas‐Linnemann, Desirée E., Pham‐Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., and Romantowski, Jan
Subjects: ASTHMA, WHEEZE, RHINITIS, ASTHMATICS, DIAGNOSIS, FATIGUE (Physiology)
Abstract: Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross‐sectional study, we assessed real‐world data using the MASK‐air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control. [ABSTRACT FROM AUTHOR]
Published: 2024
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17. Proof‐of‐concept study of anti‐Fel d 1 IgY antibodies in cat food using the MASK‐air® app.

Author: Bousquet, Jean, Gherasim, Alina, de Blay, Frédéric, Mathieu‐Dupas, Eve, Batot, Géraldine, Laune, Daniel, Sousa‐Pinto, Bernardo, Zuberbier, Torsten, Pham‐Thi, Nhân, Hofmann, Bernard, Urban‐Kraemer, Emilie, Nguyen‐Grosjean, Van‐Mai, Lustgarten, Véronique, and Defrance, Catherine
Subjects: CAT food, PROOF of concept, IMMUNOGLOBULINS, LABOR productivity, VISUAL analog scale
Abstract: Background: An innovation to better manage cat‐allergic patients utilises anti‐Fel d 1 IgY antibodies to neutralise Fel d 1 after its production by the cat. However, there is no published study showing its clinical efficacy in humans in a home setting. A longitudinal, open‐label, proof‐of‐concept study was carried out to approach clinical efficacy of the cat food in cat‐allergic patients. Methods: After a baseline evaluation, the cats ate only the cat food for the following 4 months. Daily evaluation of efficacy was performed for 2 weeks at baseline and after 1, 2 and 3 months of intervention for periods of 2 weeks. The MASK‐air app was used daily to assess symptoms, work productivity and medications. Results: Of the 49 patients screened, 42 were followed up and 33 (78.5%) reported MASK‐air data at all 3 evaluation periods. The primary end point (visual analogue scale [VAS] for global allergy symptoms) was significantly improved (p < 0.0001). All symptoms (VAS nose, eye, and asthma), VAS work and the combined symptom‐medication score significantly improved after 1 month. The percentage of uncontrolled days (VAS>20/100) decreased from 64% at baseline to 35% at 1 month (p < 0.0001) and 14% at 3 months. A sensitivity analysis in patients with uncontrolled disease at baseline found similar results. Discussion: A cat diet containing anti‐Fel d 1 antibodies was able to (i) show decreased allergic symptoms and related outcomes, (ii) inform the design and feasibility of future studies with a control arm and (iii) estimate the sample size of the study. Study registration number: clinicaltrials.gov: NCT05656482. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

Author: Bousquet, Jean, Schünemann, Holger J., Togias, Akdis, Bachert, Claus, Erhola, Martina, Hellings, Peter W., Klimek, Ludger, Pfaar, Oliver, Wallace, Dana, Ansotegui, Ignacio, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl-Christian, Bewick, Mike, Bonniaud, Philippe, Bosnic-Anticevich, Sinthia, Bossé, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Brozek, Jan, Brusselle, Guy, Calderon, Moises A., Canonica, Walter G., Caraballo, Luis, Cardona, Vicky, Casale, Thomas, Cecchi, Lorenzo, Chu, Derek K., Costa, Elisio M., Cruz, Alvaro A., Czarlewski, Wienczyslawa, D'Amato, Gennaro, Devillier, Philippe, Dykewicz, Mark, Ebisawa, Motohiro, Fauquert, Jean-Louis, Fokkens, Wytske J., Fonseca, Joao A., Fontaine, Jean-François, Gemicioglu, Bilun, van Wijk, Roy Gerth, Haahtela, Tari, Halken, Susanne, Ierodiakonou, Despo, Iinuma, Tomohisa, Ivancevich, Juan-Carlos, Jutel, Marek, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Kleine Tebbe, Jorg, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, La Grutta, Stefania, Larenas-Linnemann, Désirée, Lau, Susanne, Laune, Daniel, Le, Lan, Lieberman, Philipp, Lodrup Carlsen, Karin C., Lourenço, Olga, Marien, Gert, Carreiro-Martins, Pedro, Melén, Erik, Menditto, Enrica, Neffen, Hugo, Mercier, Gregoire, Mosgues, Ralph, Mullol, Joaquim, Muraro, Antonella, Namazova, Leyla, Novellino, Ettore, O'Hehir, Robyn, Okamoto, Yoshitaka, Ohta, Ken, Park, Hae Sim, Panzner, Petr, Passalacqua, Giovanni, Pham-Thi, Nhan, Price, David, Roberts, Graham, Roche, Nicolas, Rolland, Christine, Rosario, Nelson, Ryan, Dermot, Samolinski, Boleslaw, Sanchez-Borges, Mario, Scadding, Glenis K., Shamji, Mohamed H., Sheikh, Aziz, Bom, Ana-Maria Todo, Toppila-Salmi, Sanna, Tsiligianni, Ioana, Valentin-Rostan, Marylin, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Waserman, Susan, Yorgancioglu, Arzu, and Zuberbier, Torsten
Published: 2020
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19. Mobile Technology in Allergic Rhinitis: Evolution in Management or Revolution in Health and Care?

Author: Bousquet, Jean, Ansotegui, Ignacio J., Anto, Josep M., Arnavielhe, Sylvie, Bachert, Claus, Basagaña, Xavier, Bédard, Annabelle, Bedbrook, Anna, Bonini, Matteo, Bosnic-Anticevich, Sinthia, Braido, Fulvio, Cardona, Vicky, Czarlewski, Wienczyslawa, Cruz, Alvaro A., Demoly, Pascal, De Vries, Govert, Dramburg, Stephanie, Mathieu-Dupas, Eve, Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Ivancevich, Juan Carlos, Jormanainen, Vesa, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Laune, Daniel, Larenas-Linnemann, Désirée, Lourenço, Olga, Onorato, Gabrielle L., Matricardi, Paolo M., Melén, Erik, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Pham-Thi, Nhân, Sheikh, Aziz, Tan, Rachel, To, Teresa, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tripodi, Salvadore, Wallace, Dana, Valiulis, Arunas, van Eerd, Michiel, Ventura, Maria Teresa, Yorgancioglu, Arzu, and Zuberbier, Torsten
Published: 2019
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20. Physiopathologie de l'hypersensibilité immédiate

Author: Pham Thi, Nhân, primary
Published: 2021
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21. Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report

Author: Bousquet, Jean, primary, Shamji, Mohamed H., additional, Anto, Josep M., additional, Schünemann, Holger J., additional, Canonica, G. Walter, additional, Jutel, Marek, additional, Del Giacco, Stefano, additional, Zuberbier, Torsten, additional, Pfaar, Oliver, additional, Fonseca, Joao A., additional, Sousa‐Pinto, Bernardo, additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Chaves Loureiro, Claudia, additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Kulus, Marek, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Matricardi, Paolo M., additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Sofiev, Mikhail, additional, Toppila‐Salmi, Sanna, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Barbara, Cristina, additional, Bergmann, Karl C., additional, Bewick, Michael, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Boulet, Louis‐Philippe, additional, Bourret, Rodolphe, additional, Brusselle, Guy, additional, Brussino, Luisa, additional, Buhl, Roland, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Dramburg, Stephanie, additional, Fokkens, Wytske J., additional, Gotua, Maia, additional, Heffler, Enrico, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Joos, Guy, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Lourenço, Olga, additional, Louis, Renaud, additional, Makela, Mika, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, O'Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Olze, Heidi, additional, Papadopoulos, Nikolaos G., additional, Papi, Alberto, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Pham‐Thi, Nhân, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Roche, Nicolas, additional, Rouadi, Philip W., additional, Sá‐Sousa, Ana, additional, Sagara, Hironori, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Suppli Ulrik, Charlotte, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Torres, Maria J., additional, Tsiligianni, Ioanna, additional, Usmani, Omar S., additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Zidarn, Mihaela, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Chivato, Tomas, additional, and Ollert, Markus, additional
Published: 2023
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22. Improvement of daily allergy control by sublingual immunotherapy: A MASK ‐air® study

Author: Bousquet, Jean, primary, Sousa‐Pinto, Bernardo, additional, Shamji, Mohamed H., additional, Anto, Josep M., additional, Klimek, Ludger, additional, Canonica, G. Walter, additional, Czarlewski, Wienczyslawa, additional, Devillier, Philippe, additional, Haahtela, Tari, additional, Laune, Daniel, additional, Mullol, Joaquim, additional, Brussino, Luisa, additional, Cecchi, Lorenzo, additional, Kvedariene, Violeta, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Samolinski, Boleslaw, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Valovirta, Erkka, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Pfaar, Oliver, additional
Published: 2023
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23. Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air approach.

Author: UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Zuberbier, Torsten, Savouré, Marine, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S, Shamji, Mohamed H, Pépin, Jean-Louis, Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A, Pétré, Benoit, Bousquet, Jean, Anto, Josep M, Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A, Gemicioglu, Bilun, Fokkens, Wytske J, Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J, Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean-François, Gomez, R Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O'Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Zuberbier, Torsten, Savouré, Marine, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S, Shamji, Mohamed H, Pépin, Jean-Louis, Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A, Pétré, Benoit, Bousquet, Jean, Anto, Josep M, Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A, Gemicioglu, Bilun, Fokkens, Wytske J, Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J, Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean-François, Gomez, R Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O'Hehir, Robyn, Olze, Heidi, and Palamarchuk, Yuliia
Abstract: MASK-air , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air results should lead to change management in rhinitis and asthma.
Published: 2023

24. Consistent trajectories of rhinitis control and treatment in 16,177 weeks : the MASK-air® longitudinal study

Author: Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
Abstract: Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
Published: 2023
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25. Patient-centered digital biomarkers for allergic respiratory diseases and asthma:The ARIA-EAACI approach – ARIA-EAACI Task Force Report

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed., Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023

26. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023
Full Text: View/download PDF

27. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach

Author: Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., and Zuberbier, Torsten
Abstract: MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co‐operation and Development). MASK‐air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK‐air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as‐needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom‐medication score (ARIA‐EAACI‐CSMS) has been validated for clinical practice and trials. The implications of the novel MASK‐air® results should lead to change management in rhinitis and asthma.
Published: 2023

28. Development and validation of an electronic daily control score for asthma (e-DASTHMA):a real-world direct patient data study

Author: Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., and Bousquet, Jean
Abstract: Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high
Published: 2023

29. Frey Syndrome

Author: Pauliat-Desbordes, Sylvie, Cordier-Collet, Marie-Pierre, Castella, Clément, Coffinet, Laurent, Dumond, Pascale, Payot, François, Moreigne, Michel, Gouranton, Monique, Donnou, Marie-Dominique, Belloy, Carole, Turc, Yves, Ghazouani, Jamal, Terrisse, Michèle, Grué-Fertin, Pascaline, Rouyer, Claude, Hasselmann, Caroline, Collet, Christine, Blanc, Sibylle, Bourrier, Thierry, Boralevi, Franck, Sabouraud-Leclerc, Dominique, Pham-Thi, Nhân, Couderc, Laure, Deschildre, Antoine, Dutau, Guy, Albertini, Marc, Tran, Antoine, and Giovannini-Chami, Lisa
Published: 2016
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30. Photopolymerization study and adhesive properties of self-etch adhesives containing bis(acyl)phosphine oxide initiator

Author: Besse, Vincent, Derbanne, Mathieu A., Pham, Thi-Nhàn, Cook, Wayne D., and Le Pluart, Loïc
Published: 2016
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31. Consistent trajectories of rhinitis control and treatment in 16,177 weeks

Author: Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Subjects: rhinitis, real-world data, patient-reported outcomes, Immunology, Immunology and Allergy, mobile health
Abstract: Funding Information: MASK‐air® has been supported by EU grants (POLLAR, EIT Health; Structural and Development Funds, Twinning, EIP on AHA and H2020) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis and Uriach. Publisher Copyright: © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms. publishersversion published
Published: 2023

32. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group
Published: 2019
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33. MASK‐air ® real‐world data in respiratory allergy in old‐age adults

Author: Taborda‐Barata, Luis, primary, Ventura, Maria Teresa, additional, Blain, Hubert, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linneman, Désirée E., additional, Pham‐Thi, Nhân, additional, Samolinski, Boleslaw, additional, Fonseca, Joao A., additional, Bousquet, Jean, additional, and Sousa‐Pinto, Bernardo, additional
Published: 2023
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34. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach

Author: Bousquet, Jean, primary, Anto, Josep M., additional, Sousa‐Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chaves‐Loureiro, Claudia, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Gemicioglu, Bilun, additional, Fokkens, Wytske J., additional, Ivancevich, Juan Carlos, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Rouadi, Philip W., additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Zidarn, Mihaela, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bédard, Annabelle, additional, Benveniste, Samuel, additional, Bewick, Michael, additional, Bindslev‐Jensen, Carsten, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Bourret, Rodolphe, additional, Braido, Fulvio, additional, Carreiro‐Martins, Pedro, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Del Giacco, Stefano, additional, de Blay, Frédéric, additional, Devillier, Philippe, additional, De Vries, Govert, additional, Doulaptsi, Maria, additional, Doyen, Virginie, additional, Dray, Gérard, additional, Fontaine, Jean‐François, additional, Gomez, R. Maximiliano, additional, Hagemann, Jan, additional, Heffler, Enrico, additional, Hofmann, Maja, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, Kritikos, Vicky, additional, Kull, Inger, additional, Kulus, Marek, additional, Lourenço, Olga, additional, Mathieu‐Dupas, Eve, additional, Menditto, Enrica, additional, Mösges, Ralph, additional, Murray, Ruth, additional, Nadif, Rachel, additional, Neffen, Hugo, additional, Nicola, Stefania, additional, O’Hehir, Robyn, additional, Olze, Heidi, additional, Palamarchuk, Yuliia, additional, Pépin, Jean‐Louis, additional, Pétré, Benoit, additional, Picard, Robert, additional, Pitsios, Constantinos, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Raciborski, Filip, additional, Reitsma, Sietze, additional, Roche, Nicolas, additional, Rodriguez‐Gonzalez, Monica, additional, Romantowski, Jan, additional, Sá‐Sousa, Ana, additional, Serpa, Faradiba S., additional, Savouré, Marine, additional, Shamji, Mohamed H., additional, Sova, Milan, additional, Sperl, Annette, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Vandenplas, Olivier, additional, Van Eerd, Michiel, additional, Vasankari, Tuula, additional, Viart, Frédéric, additional, Waserman, Susan, additional, Fonseca, Joao A., additional, and Zuberbier, Torsten, additional
Published: 2023
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35. Cutoff Values of MASK-air Patient-Reported Outcome Measures

Author: Sousa-Pinto, Bernardo, primary, Sá-Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Pereira, Ana Margarida, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas-Linnemann, Desirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Ansotegui, Ignacio J., additional, Bosnic-Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais-Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham-Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Taborda-Barata, Luis, additional, Toppila-Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
Published: 2022
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36. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK‐air® longitudinal study

Author: Sousa‐Pinto, Bernardo, primary, Schünemann, Holger J., additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Eklund, Patrik, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
Published: 2022
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37. Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities

Author: Sousa‐Pinto, Bernardo, primary, Anto, Aram, additional, Berger, Markus, additional, Dramburg, Stephanie, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Jutel, Marek, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Valiulis, Arunas, additional, Agache, Ioana, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bastl, Katharina, additional, Berger, Uwe, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Canonica, G. Walter, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Chivato, Tomás, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Durham, Stephen R., additional, Ebisawa, Motohiro, additional, Fiocchi, Alessandro, additional, Fokkens, Wytske J., additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guzmán, Maria‐Antonieta, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Lipworth, Brian, additional, Laune, Daniel, additional, Matricardi, Paolo M., additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Neffen, Hugo, additional, Nekam, Kristoff, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Park, Hae‐Sim, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Pelosi, Simone, additional, Pham‐Thi, Nhân, additional, Popov, Ted A., additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rodriguez‐Gonzales, Monica, additional, Rosario, Nelson, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sá‐Sousa, Ana, additional, Sastre, Joaquin, additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Tripodi, Salvatore, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Valero, Antonio A., additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Williams, Sian, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Zidarn, Mihaela, additional, Zuberbier, Jaron, additional, Olze, Heidi, additional, Antó, Josep M., additional, Zuberbier, Torsten, additional, Fonseca, João A., additional, and Bousquet, Jean, additional
Published: 2022
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38. The ARIA-MASK-air® approach

Author: Bousquet, Jean, Anto, Josep M., Sousa-Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves-Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev-Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro-Martins, Pedro, Charpin, Denis, Cherrez-Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu-Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romantowski, Jan, Sá-Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS
Subjects: Pulmonary and Respiratory Medicine, rhinitis, mHealth, digital, Immunology, Immunology and Allergy, asthma, MASK-air
Abstract: Funding Information: The authors thank Ms Véronique Pretschner for submitting the paper. MASK‐air has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. None for the study. ® Publisher Copyright: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. MASK-air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma. publishersversion published
Published: 2023

39. The ARIA approach of Value-Added Medicines:as-needed treatment in allergic rhinitis

Author: Bousquet, Jean, Toumi, Mondher, Sousa-Pinto, Bernardo, Anto, Josep M, Bedbrook, Anna, Czarlewski, Wienczyslawa, Valiulis, Arunas, Ansotegui, Ignacio J, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Canonica, G Walter, Cecchi, Lorenzo, Cherrez-Ojeda, Ivan, Chivato, Tomas, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Fonseca, Joao A, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Jutel, Marek, Kaidashev, Igor, Klimek, Ludger, Kvedariene, Violeta, Kuna, Piotr, Larenas-Linnemann, Désirée E, Lipworth, Brian, Morais-Almeida, Mario, Mullol, Joaquim, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Taborda-Barata, Luis, Ventura, Maria Teresa, Yorgancioglu, Arzu, Zidarn, Mihaela, and Zuberbier, Torsten
Subjects: Treatment, Value-added medicine, MASK-air, Repurposing, Allergic rhinitis
Abstract: Drug repurposing is a major field of value-added medicine. It involves investigating and evaluating existing drugs for new therapeutic purposes that address unmet healthcare needs. Several unmet needs in allergic rhinitis could be improved by drug repurposing. This could be game-changing for disease management. Current medications for allergic rhinitis are centered on continuous long-term treatment, and medication registration is based on randomized controlled trials carried out for a minimum of 14 days with adherence of 70% or greater. A new way of treating allergic rhinitis is to propose as-needed treatment depending on symptoms, rather than classical continuous treatment. This rostrum will discuss existing clinical trials on as-needed treatment for allergic rhinitis and real-world data obtained by the mobile health app MASK-air, which focuses on digitally-enabled, patient-centered care pathways.
Published: 2022

40. The effect of functional monomer chain spacer length on the bond strength of an experimental dental adhesive

Author: Derbanne, Mathieu A., Besse, Vincent, Le Goff, Stéphane, Sadoun, Michaël, and Pham, Thi Nhàn
Published: 2014
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41. A study using MASK-air® real-world data

Author: Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC), and Comprehensive Health Research Centre (CHRC) - pólo NMS
Abstract: Funding: This study was funded by ARIA. MASK-air® has been supported by EU grants (EU Structural and Development grant, POLLAR: EIT Health and Structural and Development Funds) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open Access funding enabled and organized by Projekt DEAL. BACKGROUND: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. METHODS: We analysed 2015-2020 MASK-air® European data. We compared days under no medication, monotherapy, and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ("VAS Global Symptoms") and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within one year. RESULTS: We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy, and 38,315 (17.3%) under co-medication. The median "VAS Global Symptoms" was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p
Published: 2022

42. Supercritical CO2–ionic liquids: Green combination for preparing foams

Author: Livi, Sebastien, Pham, Thi Nhàn, Gérard, Jean-François, and Duchet-Rumeau, Jannick
Published: 2014
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43. Comparison of rhinitis treatments using MASK ‐air® data and considering the minimal important difference

Author: Sousa‐Pinto, Bernardo, primary, Schünemann, Holger J., additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Anto, Josep M., additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Pfaar, Oliver, additional, Bedbrook, Anna, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Desirée, additional, Okamoto, Yoshitaka, additional, Ventura, Maria Teresa, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brozek, Jan, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elísio M., additional, Cruz, Alvaro A., additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Eklund, Patrik, additional, Fokkens, Wytske J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kraxner, Helga, additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michael, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Niedoszytko, Marek, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
Published: 2022
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44. Hydrolytically stable acidic monomers used in two steps self-etch adhesives

Author: Derbanne, Mathieu A., Besse, Vincent, Le Goff, Stéphane, Sadoun, Michaël, and Pham, Thi-Nhàn
Published: 2013
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45. Results of a Bayesian mixed-effects model

Author: Sousa-Pinto, Bernardo, Azevedo, Luís Filipe, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Anto, Josep M., Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bergmann, Karl Christian, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J., Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E., Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michaël, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, Pfaar, Oliver, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS
Subjects: Pulmonary and Respiratory Medicine, allergic rhinitis, patient-reported outcomes, Immunology, Immunology and Allergy, real-life data analysis, immunotherapy, mobile health
Abstract: Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. Background: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods: We assessed the MASK-air® data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. Results: We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion: In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its ‘real-world’ effectiveness. publishersversion published
Published: 2022

46. Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference

Author: Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., Bousquet, Jean, Sousa-Pinto, Bernardo, Schünemann, Holger J., Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elísio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A., and Bousquet, Jean
Abstract: Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real-world data”). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. Methods: We assessed the MASK-air® app data (May 2015–December 2020) by users self-reporting AR (16–90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. Results: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71–0.80). Conclusion: Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.
Published: 2022
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47. Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air real-world data.

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Antó, Josep M, Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J, Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J, Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, and Bousquet, Jean
Abstract: Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. We analysed 2015-2020 MASK-air European data. We compared days under no medication, monotherapy, and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ("VAS Global Symptoms") and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within one year. We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy, and 38,315 (17.3%) under co-medication. The median "VAS Global Symptoms" was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p<0.001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H -antihistamines were the most common medication in single and co-medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. AR medication patterns are similar across European regions. One third of treatment days involved co-medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR), and that co-medication use is driven by symptom severity.
Published: 2022

48. Development and validation of combined symptom-medication scores for allergic rhinitis*

Author: Sousa-Pinto, Bernardo, Azevedo, Luís Filipe, Jutel, Marek, Agache, Ioana, Canonica, G. Walter, Czarlewski, Wienczyslawa, Papadopoulos, Nikolaos G., Bergmann, Karl-Christian, Devillier, Philippe, Laune, Daniel, Klimek, Ludger, Anto, Aram, Anto, Josep M., Eklund, Patrik, Almeida, Rute, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brough, Helen A., Brussino, Luisa, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Chivato, Tomás, Costa, Elisio M., Cruz, Alvaro A., Dramburg, Stephanie, Durham, Stephen R., De Feo, Giulia, Gerth van Wijk, Roy, Fokkens, Wystke J., Gemicioglu, Bilun, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan Carlos, Kvedariene, Violeta, Kuna, Piotr, Larenas-Linnemann, Désirée E., Makris, Michael, Mathieu-Dupas, Eve, Melén, Erik, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Nadeau, Kari C., Pham-Thi, Nhân, O’Hehir, Robyn, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Sheikh, Aziz, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Ventura, Maria Teresa, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, De Vries, Govert, van Eerd, Michiel, Zieglmayer, Petra, Zuberbier, Torsten, Pfaar, Oliver, Almeida Fonseca, João, Bousquet, Jean, Sousa-Pinto, Bernardo, Azevedo, Luís Filipe, Jutel, Marek, Agache, Ioana, Canonica, G. Walter, Czarlewski, Wienczyslawa, Papadopoulos, Nikolaos G., Bergmann, Karl-Christian, Devillier, Philippe, Laune, Daniel, Klimek, Ludger, Anto, Aram, Anto, Josep M., Eklund, Patrik, Almeida, Rute, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brough, Helen A., Brussino, Luisa, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Chivato, Tomás, Costa, Elisio M., Cruz, Alvaro A., Dramburg, Stephanie, Durham, Stephen R., De Feo, Giulia, Gerth van Wijk, Roy, Fokkens, Wystke J., Gemicioglu, Bilun, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan Carlos, Kvedariene, Violeta, Kuna, Piotr, Larenas-Linnemann, Désirée E., Makris, Michael, Mathieu-Dupas, Eve, Melén, Erik, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Nadeau, Kari C., Pham-Thi, Nhân, O’Hehir, Robyn, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Sheikh, Aziz, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Ventura, Maria Teresa, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, De Vries, Govert, van Eerd, Michiel, Zieglmayer, Petra, Zuberbier, Torsten, Pfaar, Oliver, Almeida Fonseca, João, and Bousquet, Jean
Abstract: Background: Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate hypothesis- and data-driven CSMSs. Methods: We used MASK-air® data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air® data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air®, and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results: We assessed 317,176 days of MASK-air® use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion: The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.
Published: 2022
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49. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study.

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, Bousquet, Jean, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Désirée E, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, and Bousquet, Jean
Abstract: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. We analyzed MASK-air® data, assessing weeks when patients answered a rhinitis daily questionnaire on all seven days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used latent class mixture model to assess robustness of results. We analyzed 113,239 days (16,177 complete weeks) from 2,590 patients (mean age±SD=39.1±13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week, and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed higher frequency of rhinitis co-medication, more frequent change of medication schemes, and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
Published: 2022

50. Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference.

Author: UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, Bousquet, Jean, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sousa-Pinto, Bernardo, Schünemann, Holger J, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J, Bergmann, Karl C, Bosnic-Anticevich, Sinthia, Brozek, Jan, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomas, Chu, Derek K, Cingi, Cemal, Costa, Elísio M, Cruz, Alvaro A, Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J, Gemicioglu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G, Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S, Reitsma, Sietze, Rouadi, Philip W, Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A, and Bousquet, Jean
Abstract: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. We assessed the MASK-air® app data (May 2015-December 2020) by users self-reporting AR (16-90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71-0.80). Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.
Published: 2022

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