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2 results on '"Phase 1 introns"'

1. A possible role of exon-shuffling in the evolution of signal peptides of human proteins

Author

Vibranovski, Maria Dulcetti, Sakabe, Noboru Jo, and de Souza, Sandro José

Subjects
*EXONS (Genetics), *BIOLOGICAL evolution, *PEPTIDES, *GENE expression
Abstract

Abstract: It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes [Tordai, H. and Patthy, L. (2004) Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides. FEBS Lett. 575, 109–111]. It was suggested that this biased distribution was due to intron insertion at AG∣G proto-splice sites. However, we found that there is no disproportional excess of AG∣G that would support insertion at proto-splice sites. In fact, all nG∣G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon-shuffling is largely responsible for such excess of phase 1 introns. [Copyright &y& Elsevier]

Published
2006
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2. A possible role of exon-shuffling in the evolution of signal peptides of human proteins

Author

Sandro J. de Souza, Noboru J. Sakabe, and Maria D. Vibranovski

Subjects
Signal peptide, RNA Splicing, Biophysics, Biology, Protein Sorting Signals, Exon shuffling, Cleavage (embryo), Biochemistry, Evolution, Molecular, Structural Biology, Genetics, Humans, Molecular Biology, Human proteins, Recombination, Genetic, Splice site mutation, Proto-splice site, Phase 1 introns, Intron, Proteins, Cell Biology, Exons, Exon-shuffling, Introns, Human genome, RNA Splice Sites
Abstract

It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes [Tordai, H. and Patthy, L. (2004) Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides. FEBS Lett. 575, 109–111]. It was suggested that this biased distribution was due to intron insertion at AG∣G proto-splice sites. However, we found that there is no disproportional excess of AG∣G that would support insertion at proto-splice sites. In fact, all nG∣G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon-shuffling is largely responsible for such excess of phase 1 introns.

Published
2005

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