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15 results on '"Phintuyothin P"'

2. Mefloquine kinetics in cured and recrudescent patients with acute falciparum malaria and in healthy volunteers

Author

Boudreau, Ellen F, Fleckenstein, Lawrence, Pang, Lorrin W, Childs, George E, Schroeder, Alan C, Ratnaratorn, Burapa, and Phintuyothin, Phung

Abstract

Mefloquine pharmacokinetics were compared in a randomized clinical trial in Thailand among patients with malaria and healthy volunteers. A single oral dose of 1500 mg mefloquine hydrochloride was administered to 11 patients and 5 volunteers and 750 mg was given to 16 patients and 5 volunteers. Efficacy was 82% for 1500 mg and 63% for 750 mg. In cured patients taking 750 mg mefloquine, peak plasma drug concentration (Cmax) and area under the plasma concentration-time curve (AUC) were significantly greater than in the patients for whom treatment failed (p < 0.0005 and p < 0.01, respectively), and plasma mefloquine levels were significantly higher from 8 hours to 18 days after treatment. Mefloquine AUC was reduced and variable in the presence of diarrhea. Compared with noninfected volunteers, clinically ill patients displayed a delayed time to reach peak concentration (p < 0.01) and significantly higher mefloquine plasma levels in the first 2 days after administration of either the 750 mg or the 1500 mg dose. Mefloquine AUC was similar in patients with malaria and healthy volunteers. Because plasma levels increased in temporal relationship with clinical illness, mefloquine volume of distribution or clearance (or both) was reduced during the acute phase of illness.

Published
1990
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7. Preliminary study of WR 33063 in the treatment of falciparum malaria in northeast Thailand.

Author

Segal HE, Chinvanthananond P, Laixuthai B, Phintuyothin P, Pearlman EJ, Na-Nakorn A, and Castaneda BF

Subjects
Adolescent, Adult, Antibodies analysis, Antimalarials adverse effects, Clinical Trials as Topic, Ethanolamines adverse effects, Ethanolamines therapeutic use, Fever etiology, Follow-Up Studies, Hematocrit, Humans, Kidney Function Tests, Leukocyte Count, Liver Function Tests, Malaria blood, Malaria complications, Malaria diagnosis, Malaria immunology, Male, Middle Aged, Parasite Egg Count, Phenanthrenes adverse effects, Quinine adverse effects, Quinine therapeutic use, Thailand, Antimalarials therapeutic use, Malaria drug therapy, Phenanthrenes therapeutic use, Plasmodium falciparum drug effects
Published
1974
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8. A comparative trial of Mefloquine and Fansidar in the treatment of falciparum malaria: failure of Fansidar.

Author

Dixon KE, Williams RG, Pongsupat T, Pitaktong U, and Phintuyothin P

Subjects
Drug Combinations therapeutic use, Drug Resistance, Microbial, Humans, Mefloquine, Plasmodium falciparum, Antimalarials therapeutic use, Malaria drug therapy, Pyrimethamine therapeutic use, Quinolines therapeutic use, Sulfadoxine therapeutic use, Sulfanilamides therapeutic use
Abstract

Falciparum malaria in 104 Thai patients was treated with either Mefloquine or Fansidar and patients were examined for parasitaemia for the next 28 days. All but one of the 40 patients treated with Mefloquine were cured, but the cure rates for Fansidar were only 9 . 1% for the two-tablet regimen and 19 . 4% for the three-tablet regimen. Most failures were classified as RII. Serum sulpha levels indicated that the Fansidar was being absorbed. Immediate steps should be taken to eliminate this focus of resistance and to protect against further resistance to Fansidar by using it in combination with another effective anti-malarial and by vigorous vector control measures.

Published
1982
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9. A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria.

Author

Dixon KE, Pitaktong U, and Phintuyothin P

Subjects
Adult, Chloroquine therapeutic use, Clinical Trials as Topic, Drug Therapy, Combination, Humans, Mefloquine, Plasmodium vivax, Primaquine therapeutic use, Random Allocation, Malaria drug therapy, Quinolines therapeutic use
Abstract

A clinical field trial was conducted to determine if mefloquine is effective in the treatment of malaria due to Plasmodium vivax. Forty patients with P. vivax malaria were treated with either mefloquine, chloroquine or chloroquine plus primaquine and followed for 28 days. All patients responded rapidly and were cured. There were no significant side effects.

Published
1985
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10. Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.

Author

Doberstyn EB, Phintuyothin P, Noeypatimanondh S, and Teerakiartkamjorn C

Subjects
Clinical Trials as Topic, Dose-Response Relationship, Drug, Drug Evaluation, Humans, Piperidines administration & dosage, Plasmodium falciparum, Tablets, Malaria drug therapy, Pyrimethamine administration & dosage, Quinolines administration & dosage, Sulfadoxine administration & dosage, Sulfanilamides administration & dosage
Abstract

A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.

Published
1979

11. Comparison of diaminodiphenylsulphonepyrimethamine and sulfadoxine-pyrimethamine combinations in the treatment of falciparum malaria in Thailand.

Author

Segal HE, Chinvanthananond P, Laixuthai B, Pearlman EJ, Hall AP, Phintuyothin P, Na-Nakorn A, and Castaneda BF

Subjects
Adolescent, Adult, Dapsone adverse effects, Dapsone analogs & derivatives, Drug Evaluation, Drug Synergism, Female, Humans, Male, Middle Aged, Plasmodium falciparum analysis, Pyrimethamine adverse effects, Sulfadoxine adverse effects, Sulfadoxine analogs & derivatives, Thailand, Dapsone therapeutic use, Malaria drug therapy, Plasmodium falciparum drug effects, Pyrimethamine therapeutic use, Sulfadoxine therapeutic use, Sulfanilamides therapeutic use
Published
1975
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12. Malaria prophylaxis with doxycycline in soldiers deployed to the Thai-Kampuchean border.

Author

Watanasook C, Singharaj P, Suriyamongkol V, Karwacki JJ, Shanks D, Phintuyothin P, Pilungkasa S, and Wasuwat P

Subjects
Dose-Response Relationship, Drug, Drug Combinations therapeutic use, Drug Evaluation, Humans, Male, Military Personnel, Random Allocation, Thailand, Antimalarials therapeutic use, Dapsone therapeutic use, Doxycycline therapeutic use, Malaria prevention & control, Pyrimethamine therapeutic use
Abstract

A battalion of Royal Thai Marine militia was assigned to take either 50 mg or 100 mg of doxycycline daily or pyrimethamine/dapsone weekly for malaria prophylaxis on the Thai-Kampuchean border for a 17 week period. Attack rates for the groups expressed as cases/100 men were 34 for 50 mg doxycycline, 18 for 100 mg doxycycline, and 52 for pyrimethamine/dapsone. The relative efficacy of the two doxycycline regimens compared to Maloprim were 1.6 and 1.4. Compliance with the daily drug nearly equalled that of the weekly regimen. This suggests that 100 mg of doxycycline daily can be effectively used for malaria prophylaxis by soldiers under operational conditions on the Thai-Kampuchean border.

Published
1989

14. Evaluation of an in vitro technique for detecting chloroquine resistant falciparum malaria in Thailand.

Author

Colwell EJ, Phintuyothin P, Sadudee N, Benjapong W, and Neoypatimanondh S

Subjects
Adolescent, Adult, Aged, Animals, Chloroquine therapeutic use, Drug Resistance, Microbial, Female, Humans, Male, Metamorphosis, Biological drug effects, Methods, Middle Aged, Thailand, Time Factors, Chloroquine pharmacology, Malaria drug therapy, Plasmodium falciparum drug effects
Published
1972
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