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5. Bisphenol-A Mediated Impaired DRP1-GFER Axis and Cognition Restored by PGC-1α Upregulation Through Nicotinamide in the Rat Brain Hippocampus

Author

Shweta Goyal, Saurabh Tiwari, Brashket Seth, null Phoolmala, Ankit Tandon, and Rajnish Kumar Chaturvedi

Subjects
Dynamins, Niacinamide, Neuroscience (miscellaneous), Proteins, Hippocampus, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Rats, Up-Regulation, Cellular and Molecular Neuroscience, Cognition, Phenols, Neurology, Tubulin, Animals, Benzhydryl Compounds
Abstract

The regulatory network of mitochondrial biogenesis and dynamics is vital for mitochondrial functions and cellular homeostasis. Any impairment in the mitochondrial network leads to neurodegenerative disorders. Our earlier studies suggest that environmental toxicant Bisphenol-A (BPA) exposure reduces neurogenesis by abnormal mitochondrial dynamics and mitochondrial biogenesis through impairment of mitochondrial fission factor dynamin-related protein (DRP1) and mitochondrial import protein GFER, which leads to demyelination, neurodegeneration, and cognitive deficits in the rats. In the present study, we found that chronic BPA exposure reduces PGC-1α levels (master regulator of mitochondrial biogenesis), alters mitochondrial localization of DRP1 and GFER, and reduces the number of PGC-1α/NeuN

Published
2022

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