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1. Clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection: an observational cohort study

Author

Mailhe, Morgane, Beaumont, Anne-Lise, Thy, Michael, Le Pluart, Diane, Perrineau, Ségolène, Houhou-Fidouh, Nadhira, Deconinck, Laurène, Bertin, Chloé, Ferré, Valentine Marie, Cortier, Marie, De La Porte Des Vaux, Clémentine, Phung, Bao-Chau, Mollo, Bastien, Cresta, Mélanie, Bouscarat, Fabrice, Choquet, Christophe, Descamps, Diane, Ghosn, Jade, Lescure, François-Xavier, Yazdanpanah, Yazdan, Joly, Véronique, and Peiffer-Smadja, Nathan

Published
2023
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3. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Bazzalo, Ignacio J., Casas, Marcelo M., Nuñez, Sebastián A., Pere, Yael, Ibarrola, Carlos M., Solis Aramayo, Marco A., Cuesta, Maria C., Duarte, Andrea E., Gutierrez Fernandez, Pablo M., Iannantuono, Maria A., Miyazaki, Erica A., Silvio, Javier P., Scublinsky, Dario G., Bales, Alessandra, Catarino, Daniela, Fiss, Elie, Mohrbacher, Sara, Sato, Victor, Baylao, Antonio, Cavalcante, Adilson, Correa, Francini, de Andrade, Celso A., Furtado, Juvencio, Ribeiro Filho, Nelson, Telles, Valéria, Trevelin, Leopoldo T., Vipich, Ricardo, Boldo, Rodrigo, Borges, Paula, Lobo, Suzana, Luckemeyer, Graziela, Machado, Luana, Alves, Maysa B., Iglessias, Ana C., Lago, Marianna M., Santos, Daniel W., Chapdelaine, Hugo, Falcone, Emilia L., Jamal, Rahima, Luong, Me-Linh, Durand, Madeleine, Doucet, Stephane, Carrier, François-Martin, Coburn, Bryan A., Del Sorbo, Lorenzo, Walmsley, Sharon L., Belga, Sara, Chen, Luke Y., Mah, Allison D., Steiner, Theodore, Wright, Alissa J., Hajek, J., Adhikari, Neill, Fowler, Robert A., Daneman, Nick, Khwaja, Kosar A., Shahin, Jason, Gonzalez, Carolina, Silva, Rafael, Lindh, Marcelo, Maluenda, Gabriel, Fernandez, Patricia, Oyonarte, Maite, Lasso, Martin, Boyer, Alexandre, Bronnimann, Didier, Bui, Hoang-Nam, Cazanave, Charles, Chaussade, Helene, Desclaux, Arnaud, Ducours, Mailys, Duvignaud, Alexandre, Malvy, Denis, Martin, Lisa, Neau, Didier, Nguyen, Duc, Pistone, Thierry, Soubrane-Wirth, Gaetane, Leitao, Julie, Allavena, Clotilde, Biron, Charlotte, Bouchez, Sabelline, Gaborit, Benjamin, Gregoire, Antoine, Le Turnier, Paul, Lecompte, Anne-Sophie, Lecomte, Raphael, Lefebvre, Maeva, Raffi, Francois, Boutoille, David, Morineau, Pascale H., Guéry, Romain, Chatelus, Emmanuel, Dumoussaud, Nathalie, Felten, Renaud, Luca, Florina, Goichot, Bernard, Schneider, Francis, Taquet, Marie-Caroline, Groh, Matthieu, Roumier, Mathilde, Neuville, Mathilde, Bachelard, Antoine, Isernia, Valentina, Lescure, F-Xavier, Phung, Bao-Chau, Rachline, Anne, Sautereau, Aurelie, Vallois, Dorothee, Bleher, Yves, Boucher, Delphine, Coudon, Clémentine, Esnault, Jean, Guimard, Thomas, Leautez-Nainville, Sophie, Merrien, Dominique, Morrier, Marine, Motte-Vincent, Pauline, Gabeff, Romain, Leclerc, Hélène, Cozic, Céline, Decours, Romain, Février, Ronan, Colin, Gwenhael, Abgrall, Sophie, Vignes, Dorothee, Sterpu, Raluca, Kuellmar, Mira, Meersch-Dini, Melanie, Weiss, Raphael, Zarbock, Alexander, Antony, Christiane, Berger, Marc, Brenner, Thorsten, Taube, Christian, Herbstreit, Frank, Dolff, Sebastian, Konik, Margarethe, Schmidt, Karsten, Zettler, Markus, Witzke, Oliver, Boell, Boris, Garcia Borrega, Jorge, Koehler, Philipp, Zander, Thomas, Dusse, Fabian, Al-Sawaf, Othman, Köhler, Philipp, Eichenauer, Dennis, Kochanek, Matthias, Shimabukuro-Vornhagen, Alexander, Mellinghoff, Sibylle, Claßen, Annika, Heger, Jan-Michel, Meyer-Schwickerath, Charlotte, Liedgens, Paul, Heindel, Katrin, Belkin, Ana, Biber, Asaf, Gilboa, Mayan, Levy, Itzchak, Litachevsky, Vladislav, Rahav, Galia, Finesod Wiedner, Anat, Zilberman-Daniels, Tal, Oster, Yonatan, Strahilevitz, Jacob, Sviri, Sigal, Baldissera, Elena M., Campochiaro, Corrado, Cavalli, Giulio, Dagna, Lorenzo, De Luca, Giacomo, Della Torre, Emanuel, Tomelleri, Alessandro, Bernasconi De Luca, Davide, Capetti, Amedeo F., Coen, Massimo, Cossu, Maria V., Galli, Massimo, Giacomelli, Andrea, Gubertini, Guido A., Rusconi, Stefano, Burastero, Giulia J., Digaetano, Margherita, Guaraldi, Giovanni, Meschiari, Marianna, Mussini, Cristina, Puzzolante, Cinzia, Volpi, Sara, Aiello, Marina, Ariani, Alarico, Chetta, Alfredo A., Frizzelli, Annalisa, Ticinesi, Andrea, Tuttolomondo, Domenico, Aliberti, Stefano, Blasi, Francesco B., Di Pasquale, Marta F., Misuraca, Sofia, Pilocane, Tommaso, Simonetta, Edoardo, Aghelmo, Alessio M., Angelini, Claudio, Brunetta, Enrico, Canonica, Giorgio W., Ciccarelli, Michele, Dal Farra, Sara, De Santis, Maria, Ferri, Sebastian, Folci, Marco, Guidelli, Giacomo M., Heffler, Enrico M., Loiacono, Ferdinando, Malipiero, Giacomo, Paoletti, Giovanni, Pedale, Rosa, Puggioni, Francesca A., Racca, Francesca, Zumbo, Aurora, Satou, Morihiko, Honda, Hitoshi, Lisun, Tatyana, Protsenko, Denis, Rubtsov, Nikolay, Beloglazova, Irina, Fomina, Daria, Lysenko, Mariana, Serdotetskova, Sofia, Firstov, Vitali, Gordeev, Ivan, Kokorin, Ilia, Komissarova, Ksenia, Lapochkina, Nina, Luchinkina, Elena, Malimon, Valentin, Mamedguseyinova, Sevinch, Polubatonova, Ksenia, Suvorova, Natalia, Arribas, Jose, Borobia Perez, Alberto M., de la Calle Prieto, Fernando, Figueira, Juan Carlos, Motejano Sanchez, Rocio, Mora-Rillo, Marta, Prados Sanchez, Concepcion, Queiruga Parada, Javier, Fernandez Arnalich, Francisco, Guerro Barrientos, Maria, Bendala Estrada, Alejandro, Caballero Marcos, Aranzazu, Garcia Leoni, Maria E., García-Martínez, Rita, Collado, Ana María, Munoz Garcia, Patricia, Torres do Rego, Ana, Villalba García, María V., Burrillo, Almudena, Valerio Minero, Maricela, Gijon Vidaurreta, Paloma, Infante Herrero, Sonsoles, Velilla, Elena, Machado, Marina, Olmedo, Maria, Pinilla, Blanca, Almirante Gragera, Benito, Cañas Ruano, Maria de la Esperanza, Contreras Medina, Sofia, Cortés Herrera, Alejandro, Falcó Ferrer, Vicenç, Ferrer Roca, Ricard, Nuvials Casals, Xavier, Ribera Pascuet, Esteve, Suanzes Diez, Paula, Rebollo Castro, Pedro, Garcia Alcaide, Felipe, Soriano, Alejandro, Oliver Caldes, Aina, González Cordón, Ana, Cardozo, Celia, De la Mora Cañizo, Lorena, Pena López, Romina, Chamorro, Sandra, Crespillo-Andujar, Clara, Escudero Sanchez, Rosa, Fortún-Abete, Jesús, Monge-Maillo, Begoña, Moreno Zamora, Ana, Norman, Francesca, Sanchez Conde, Matilde, Serrano Villar, Sergio, Vizcarra, Pilar, Lescure, François-Xavier, Fowler, Robert A, Lazar, Jennifer Sloane, Shi, Genming, Wung, Peter, Patel, Naimish, and Hagino, Owen

Published
2021
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4. Histological Features Associated With Human Mpox Virus Infection in 2022 Outbreak in a Nonendemic Country

Author

Chalali, Faris, primary, Merlant, Marie, additional, Truong, Audrey, additional, Ghosn, Jade, additional, Phung, Bao-Chau, additional, Mollo, Bastien, additional, Perrineau, Ségolène, additional, Rahi, Mayda, additional, Fidouh-Houhou, Nadhira, additional, Ferré, Valentine Marie, additional, Brunet-Possenti, Florence, additional, Descamps, Vincent, additional, Bouscarat, Fabrice, additional, Yazdanpanah, Yazdan, additional, Deschamps, Lydia, additional, and Bertin, Chloé, additional

Published
2022
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5. Risk of HIV transmission during combined ART initiation for HIV-infected persons with severe immunosuppression

Author

Supervie, V, Assoumou, L, Breban, R, Lert, F, Costagliola, D, Pialoux, G, Landman, R, Girard, P. M, Slama, L, Cabié, André, Abel, Sylvie, Hochedez, Patrick, Pierre-François, Sandrine, Rozé, Benoît, Simon, Anne, Lupin, Catherine, Katlama, Christine, Valentin, Marc Antoine, Autran, Brigitte, Samri, Assia, Lambert, Sidonie, Marcelin, Anne Geneviève, Landman, Roland, Joly, Véronique, Julia, Zélie, Harent, Stanislas, Papot, Emmanuelle, Phung, Bao-Chau, Peytavin, Gilles, Minh, Patrick Lê, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Cahitte, Isabelle, Zeng, Feng, Mortier, Emmanuel, Pialoux, Gilles, L’Yavanc, Thomas, Le Loup, Guillaume, Bonnard, Philippe, Lebrette, Marie Gisèle, Chas, Julie, Berrebi, Valérie, Velazquez, Nadège, Adda, Anne, Duvivier, Claudine, Touam, Fatima, Lortholary, Olivier, Shoai-Tehrani, Michka, Rouzaud, Claire, Denes, Eric, Ducroux-Roubertou, Sophie, Durox, Hélène, Genet, Claire, Rogez, Jean-Philippe, Rogez, Sylvie, Pascual, Jose, Weiss, Laurence, Pavie, Juliette, Bourzam, Erila, Aumaître, Hugues, Ferreyra, Milagros, Saada, Matthieu, Malet, Martine, Palacios, Christia, Honore, Patricia, Zamord, Irene, Berthe, Huguette, Landowski, Stéphanie, de Truchis, Pierre, Perre, Philippe, Girard, Pierre-Marie, Valin, Nadia, Campa, Pauline, Lefebvre, Bénédicte, Meynard, Jean-Luc, Pauchard, Michèle, and Surgers, Laure

Published
2017
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6. Histological Features Associated With Human Mpox Virus Infection in 2022 Outbreak in a Nonendemic Country.

Author

Chalali, Faris, Merlant, Marie, Truong, Audrey, Ghosn, Jade, Phung, Bao-Chau, Mollo, Bastien, Perrineau, Ségolène, Rahi, Mayda, Fidouh-Houhou, Nadhira, Ferré, Valentine Marie, Brunet-Possenti, Florence, Descamps, Vincent, Bouscarat, Fabrice, Yazdanpanah, Yazdan, Deschamps, Lydia, and Bertin, Chloé

Subjects
SKIN, INFLAMMATION, MONKEYPOX, NEUTROPHILS, LYMPHOCYTES, SYMPTOMS, HISTOLOGY, MEN who have sex with men, CYTOPLASM
Abstract

Skin histology of papules and pustules from 5 men having sex with men with mpox infection showed viral intracytoplasmic cytopathic changes, interface dermatitis, marked inflammatory dermic infiltrate including superficial neutrophils and perivascular and periadnexal deep lymphocytes. Histologic description of mpox lesions improves our understanding about clinical presentations and may have some therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Lescure, François-Xavier, primary, Honda, Hitoshi, additional, Fowler, Robert A, additional, Lazar, Jennifer Sloane, additional, Shi, Genming, additional, Wung, Peter, additional, Patel, Naimish, additional, Hagino, Owen, additional, Bazzalo, Ignacio J., additional, Casas, Marcelo M., additional, Nuñez, Sebastián A., additional, Pere, Yael, additional, Ibarrola, Carlos M., additional, Solis Aramayo, Marco A., additional, Cuesta, Maria C., additional, Duarte, Andrea E., additional, Gutierrez Fernandez, Pablo M., additional, Iannantuono, Maria A., additional, Miyazaki, Erica A., additional, Silvio, Javier P., additional, Scublinsky, Dario G., additional, Bales, Alessandra, additional, Catarino, Daniela, additional, Fiss, Elie, additional, Mohrbacher, Sara, additional, Sato, Victor, additional, Baylao, Antonio, additional, Cavalcante, Adilson, additional, Correa, Francini, additional, de Andrade, Celso A., additional, Furtado, Juvencio, additional, Ribeiro Filho, Nelson, additional, Telles, Valéria, additional, Trevelin, Leopoldo T., additional, Vipich, Ricardo, additional, Boldo, Rodrigo, additional, Borges, Paula, additional, Lobo, Suzana, additional, Luckemeyer, Graziela, additional, Machado, Luana, additional, Alves, Maysa B., additional, Iglessias, Ana C., additional, Lago, Marianna M., additional, Santos, Daniel W., additional, Chapdelaine, Hugo, additional, Falcone, Emilia L., additional, Jamal, Rahima, additional, Luong, Me-Linh, additional, Durand, Madeleine, additional, Doucet, Stephane, additional, Carrier, François-Martin, additional, Coburn, Bryan A., additional, Del Sorbo, Lorenzo, additional, Walmsley, Sharon L., additional, Belga, Sara, additional, Chen, Luke Y., additional, Mah, Allison D., additional, Steiner, Theodore, additional, Wright, Alissa J., additional, Hajek, J., additional, Adhikari, Neill, additional, Fowler, Robert A., additional, Daneman, Nick, additional, Khwaja, Kosar A., additional, Shahin, Jason, additional, Gonzalez, Carolina, additional, Silva, Rafael, additional, Lindh, Marcelo, additional, Maluenda, Gabriel, additional, Fernandez, Patricia, additional, Oyonarte, Maite, additional, Lasso, Martin, additional, Boyer, Alexandre, additional, Bronnimann, Didier, additional, Bui, Hoang-Nam, additional, Cazanave, Charles, additional, Chaussade, Helene, additional, Desclaux, Arnaud, additional, Ducours, Mailys, additional, Duvignaud, Alexandre, additional, Malvy, Denis, additional, Martin, Lisa, additional, Neau, Didier, additional, Nguyen, Duc, additional, Pistone, Thierry, additional, Soubrane-Wirth, Gaetane, additional, Leitao, Julie, additional, Allavena, Clotilde, additional, Biron, Charlotte, additional, Bouchez, Sabelline, additional, Gaborit, Benjamin, additional, Gregoire, Antoine, additional, Le Turnier, Paul, additional, Lecompte, Anne-Sophie, additional, Lecomte, Raphael, additional, Lefebvre, Maeva, additional, Raffi, Francois, additional, Boutoille, David, additional, Morineau, Pascale H., additional, Guéry, Romain, additional, Chatelus, Emmanuel, additional, Dumoussaud, Nathalie, additional, Felten, Renaud, additional, Luca, Florina, additional, Goichot, Bernard, additional, Schneider, Francis, additional, Taquet, Marie-Caroline, additional, Groh, Matthieu, additional, Roumier, Mathilde, additional, Neuville, Mathilde, additional, Bachelard, Antoine, additional, Isernia, Valentina, additional, Lescure, F-Xavier, additional, Phung, Bao-Chau, additional, Rachline, Anne, additional, Sautereau, Aurelie, additional, Vallois, Dorothee, additional, Bleher, Yves, additional, Boucher, Delphine, additional, Coudon, Clémentine, additional, Esnault, Jean, additional, Guimard, Thomas, additional, Leautez-Nainville, Sophie, additional, Merrien, Dominique, additional, Morrier, Marine, additional, Motte-Vincent, Pauline, additional, Gabeff, Romain, additional, Leclerc, Hélène, additional, Cozic, Céline, additional, Decours, Romain, additional, Février, Ronan, additional, Colin, Gwenhael, additional, Abgrall, Sophie, additional, Vignes, Dorothee, additional, Sterpu, Raluca, additional, Kuellmar, Mira, additional, Meersch-Dini, Melanie, additional, Weiss, Raphael, additional, Zarbock, Alexander, additional, Antony, Christiane, additional, Berger, Marc, additional, Brenner, Thorsten, additional, Taube, Christian, additional, Herbstreit, Frank, additional, Dolff, Sebastian, additional, Konik, Margarethe, additional, Schmidt, Karsten, additional, Zettler, Markus, additional, Witzke, Oliver, additional, Boell, Boris, additional, Garcia Borrega, Jorge, additional, Koehler, Philipp, additional, Zander, Thomas, additional, Dusse, Fabian, additional, Al-Sawaf, Othman, additional, Köhler, Philipp, additional, Eichenauer, Dennis, additional, Kochanek, Matthias, additional, Shimabukuro-Vornhagen, Alexander, additional, Mellinghoff, Sibylle, additional, Claßen, Annika, additional, Heger, Jan-Michel, additional, Meyer-Schwickerath, Charlotte, additional, Liedgens, Paul, additional, Heindel, Katrin, additional, Belkin, Ana, additional, Biber, Asaf, additional, Gilboa, Mayan, additional, Levy, Itzchak, additional, Litachevsky, Vladislav, additional, Rahav, Galia, additional, Finesod Wiedner, Anat, additional, Zilberman-Daniels, Tal, additional, Oster, Yonatan, additional, Strahilevitz, Jacob, additional, Sviri, Sigal, additional, Baldissera, Elena M., additional, Campochiaro, Corrado, additional, Cavalli, Giulio, additional, Dagna, Lorenzo, additional, De Luca, Giacomo, additional, Della Torre, Emanuel, additional, Tomelleri, Alessandro, additional, Bernasconi De Luca, Davide, additional, Capetti, Amedeo F., additional, Coen, Massimo, additional, Cossu, Maria V., additional, Galli, Massimo, additional, Giacomelli, Andrea, additional, Gubertini, Guido A., additional, Rusconi, Stefano, additional, Burastero, Giulia J., additional, Digaetano, Margherita, additional, Guaraldi, Giovanni, additional, Meschiari, Marianna, additional, Mussini, Cristina, additional, Puzzolante, Cinzia, additional, Volpi, Sara, additional, Aiello, Marina, additional, Ariani, Alarico, additional, Chetta, Alfredo A., additional, Frizzelli, Annalisa, additional, Ticinesi, Andrea, additional, Tuttolomondo, Domenico, additional, Aliberti, Stefano, additional, Blasi, Francesco B., additional, Di Pasquale, Marta F., additional, Misuraca, Sofia, additional, Pilocane, Tommaso, additional, Simonetta, Edoardo, additional, Aghelmo, Alessio M., additional, Angelini, Claudio, additional, Brunetta, Enrico, additional, Canonica, Giorgio W., additional, Ciccarelli, Michele, additional, Dal Farra, Sara, additional, De Santis, Maria, additional, Ferri, Sebastian, additional, Folci, Marco, additional, Guidelli, Giacomo M., additional, Heffler, Enrico M., additional, Loiacono, Ferdinando, additional, Malipiero, Giacomo, additional, Paoletti, Giovanni, additional, Pedale, Rosa, additional, Puggioni, Francesca A., additional, Racca, Francesca, additional, Zumbo, Aurora, additional, Satou, Morihiko, additional, Lisun, Tatyana, additional, Protsenko, Denis, additional, Rubtsov, Nikolay, additional, Beloglazova, Irina, additional, Fomina, Daria, additional, Lysenko, Mariana, additional, Serdotetskova, Sofia, additional, Firstov, Vitali, additional, Gordeev, Ivan, additional, Kokorin, Ilia, additional, Komissarova, Ksenia, additional, Lapochkina, Nina, additional, Luchinkina, Elena, additional, Malimon, Valentin, additional, Mamedguseyinova, Sevinch, additional, Polubatonova, Ksenia, additional, Suvorova, Natalia, additional, Arribas, Jose, additional, Borobia Perez, Alberto M., additional, de la Calle Prieto, Fernando, additional, Figueira, Juan Carlos, additional, Motejano Sanchez, Rocio, additional, Mora-Rillo, Marta, additional, Prados Sanchez, Concepcion, additional, Queiruga Parada, Javier, additional, Fernandez Arnalich, Francisco, additional, Guerro Barrientos, Maria, additional, Bendala Estrada, Alejandro, additional, Caballero Marcos, Aranzazu, additional, Garcia Leoni, Maria E., additional, García-Martínez, Rita, additional, Collado, Ana María, additional, Munoz Garcia, Patricia, additional, Torres do Rego, Ana, additional, Villalba García, María V., additional, Burrillo, Almudena, additional, Valerio Minero, Maricela, additional, Gijon Vidaurreta, Paloma, additional, Infante Herrero, Sonsoles, additional, Velilla, Elena, additional, Machado, Marina, additional, Olmedo, Maria, additional, Pinilla, Blanca, additional, Almirante Gragera, Benito, additional, Cañas Ruano, Maria de la Esperanza, additional, Contreras Medina, Sofia, additional, Cortés Herrera, Alejandro, additional, Falcó Ferrer, Vicenç, additional, Ferrer Roca, Ricard, additional, Nuvials Casals, Xavier, additional, Ribera Pascuet, Esteve, additional, Suanzes Diez, Paula, additional, Rebollo Castro, Pedro, additional, Garcia Alcaide, Felipe, additional, Soriano, Alejandro, additional, Oliver Caldes, Aina, additional, González Cordón, Ana, additional, Cardozo, Celia, additional, De la Mora Cañizo, Lorena, additional, Pena López, Romina, additional, Chamorro, Sandra, additional, Crespillo-Andujar, Clara, additional, Escudero Sanchez, Rosa, additional, Fortún-Abete, Jesús, additional, Monge-Maillo, Begoña, additional, Moreno Zamora, Ana, additional, Norman, Francesca, additional, Sanchez Conde, Matilde, additional, Serrano Villar, Sergio, additional, and Vizcarra, Pilar, additional

Published
2021
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10. Incidence of and risk factors for medical care interruption in people living with HIV in recent years

Author

Fournier, Anna Lucie, Yazdanpanah, Yazdan, Verdon, Renaud, Lariven, Sylvie, Mackoumbou-Nkouka, Claude, Phung, Bao-Chau, Papot, Emmanuelle, Parienti, Jean-Jacques, Landman, Roland, Champenois, Karen, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Unité de Maladies Infectieuses et Tropicales [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut de médecine et d'épidémiologie appliquée [AP-HP Hôpital Bichat-Claude Bernard] (IMEA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), and Mzembaba, Sandy

Subjects
RNA viruses, Male, Medical Doctors, Health Care Providers, HIV Infections, Pathology and Laboratory Medicine, Geographical locations, Immunodeficiency Viruses, Risk Factors, Public and Occupational Health, Medical Personnel, ComputingMilieux_MISCELLANEOUS, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Incidence, HIV diagnosis and management, Viral Load, Middle Aged, Vaccination and Immunization, Europe, Professions, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Anti-Retroviral Agents, Medical Microbiology, Viral Pathogens, Viruses, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Medicine, Female, France, Pathogens, Research Article, Adult, Science, Immunology, Antiretroviral Therapy, Microbiology, Antiviral Therapy, Physicians, Virology, Retroviruses, Humans, European Union, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Microbial Pathogens, Primary Care, Africa South of the Sahara, Medicine and health sciences, Lentivirus, Organisms, Biology and Life Sciences, HIV, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Diagnostic medicine, CD4 Lymphocyte Count, Health Care, People and Places, HIV-1, Population Groupings, Preventive Medicine, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Delivery of Health Care, Viral Transmission and Infection, Follow-Up Studies
Abstract

ObjectivesWith HIV treatment as a prevention strategy, retention in care remains a key for sustained viral suppression. We sought to identify HIV-infected patients at risk for medical care interruption (MCI) in a high-income country.MethodsThe HIV-infected patients enrolled had to attend the clinic at least twice between January 2010 and October 2014 and were followed up until May 2016. MCI was defined as patients not seeking care in or outside the clinic for at least 18 months, regardless of whether they returned to care after the interruption. The association between MCI and sociodemographic, clinical, and immuno-virological characteristics at HIV diagnosis and during follow-up was assessed using Cox models.ResultsThe incidence rate of MCI was 2.5 per 100 persons-years (95% confidence interval [CI] = 2.3-2.7). MCI was more likely in patients who accessed care >6 months after diagnosis (hazard ratio [HR] = 1.30, 95% CI = 1.10-1.54 vs. ≤6 months) or did not report a primary care physician (HR = 2.40; 95% CI = 2.03-2.84). MCI was less likely in patients born in sub-Saharan Africa (HR = 0.75, 95% CI = 0.62-0.91 vs. born in France). During follow-up, the risk of MCI increased when the last CD4 count was ≤350 (HR = 2.85, 95% CI = 2.02-4.04 vs. >500 cells/mm3) and when the patient was not on antiretroviral therapy (HR = 3.67, 95% CI = 2.90-4.66).ConclusionsThe incidence of MCI is low in this hospital that serves a large proportion of migrants. Low or no recorded CD4 counts for a medical visit could alert of a higher risk of MCI, even more in patients who accessed HIV care late or did not report a primary care physician.

Published
2019

12. Real-world data on long-acting intramuscular maintenance therapy with cabotegravir and rilpivirine mirror Phase 3 results.

Author

Serris A, Ferre VM, Le Hingrat Q, Bachelard A, Charpentier C, Exarchopoulos M, Damond F, Phung BC, Landman R, Yazdanpanah Y, Descamps D, Joly V, Peytavin G, and Ghosn J

Abstract

Introduction: Cabotegravir, an integrase strand transfer inhibitor, and rilpivirine, an NNRTI, constitute the first long-acting (LA), injectable, two-drug ART regimen approved for the maintenance of virological suppression in persons living with HIV-1 (PLHIV). The aim of this study was to assess clinical effectiveness and tolerability of LA cabotegravir/rilpivirine in a real-world setting., Patients and Methods: We conducted a retrospective, single centre study, including all PLHIV receiving LA cabotegravir/rilpivirine as standard-of-care in our tertiary centre even if initiated in clinical trials., Results: Between 2014 and 2022, 126 PLHIV initiated LA cabotegravir/rilpivirine. All were ART-experienced, and 98.4% had a viral load (VL) of <50 copies/mL before LA cabotegravir/rilpivirine initiation. Median BMI at cabotegravir/rilpivirine initiation was 24 IQR (23-28). During a median follow-up of 9 months IQR (7-24), 27 patients discontinued cabotegravir/rilpivirine because of virological failure, 6 for adverse events, 11 for personal reasons unrelated to treatment tolerance and 5 for other reasons. Virological failure was not associated with a higher BMI, nor with weight gain during LA intramuscular (IM) cabotegravir/rilpivirine treatment, inadequate cabotegravir and rilpivirine concentrations, VL blips or the use of oral lead-in (OLI) or not. No drug resistance-associated mutation emerged. Adverse events leading to treatment interruption were injection-site pain (n = 3) and neuropsychological side effects (n = 3). A correlation between BMI and both cabotegravir and rilpivirine concentrations at 1 month post-initiation of LA-IM cabotegravir/rilpivirine was observed, with no impact of OLI., Conclusions: Data from this real-world cohort of PLHIV who received cabotegravir/rilpivirine LA injections suggest that this regimen is effective and well tolerated. Virological failures were not associated with the acquisition of resistance mutations., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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13. Incidence of and risk factors for medical care interruption in people living with HIV in recent years.

Author

Fournier AL, Yazdanpanah Y, Verdon R, Lariven S, Mackoumbou-Nkouka C, Phung BC, Papot E, Parienti JJ, Landman R, and Champenois K

Subjects
Adult, Africa South of the Sahara epidemiology, CD4 Lymphocyte Count, Female, Follow-Up Studies, France epidemiology, Humans, Incidence, Male, Middle Aged, Risk Factors, Anti-Retroviral Agents administration & dosage, Delivery of Health Care, HIV Infections blood, HIV Infections drug therapy, HIV Infections epidemiology, HIV-1
Abstract

Objectives: With HIV treatment as a prevention strategy, retention in care remains a key for sustained viral suppression. We sought to identify HIV-infected patients at risk for medical care interruption (MCI) in a high-income country., Methods: The HIV-infected patients enrolled had to attend the clinic at least twice between January 2010 and October 2014 and were followed up until May 2016. MCI was defined as patients not seeking care in or outside the clinic for at least 18 months, regardless of whether they returned to care after the interruption. The association between MCI and sociodemographic, clinical, and immuno-virological characteristics at HIV diagnosis and during follow-up was assessed using Cox models., Results: The incidence rate of MCI was 2.5 per 100 persons-years (95% confidence interval [CI] = 2.3-2.7). MCI was more likely in patients who accessed care >6 months after diagnosis (hazard ratio [HR] = 1.30, 95% CI = 1.10-1.54 vs. ≤6 months) or did not report a primary care physician (HR = 2.40; 95% CI = 2.03-2.84). MCI was less likely in patients born in sub-Saharan Africa (HR = 0.75, 95% CI = 0.62-0.91 vs. born in France). During follow-up, the risk of MCI increased when the last CD4 count was ≤350 (HR = 2.85, 95% CI = 2.02-4.04 vs. >500 cells/mm3) and when the patient was not on antiretroviral therapy (HR = 3.67, 95% CI = 2.90-4.66)., Conclusions: The incidence of MCI is low in this hospital that serves a large proportion of migrants. Low or no recorded CD4 counts for a medical visit could alert of a higher risk of MCI, even more in patients who accessed HIV care late or did not report a primary care physician., Competing Interests: I have read the journal's policy and the authors of this manuscript have the following updated competing interests: YY has served as a speaker and as a consultant for Abbott, Bristol-Myers Squibb, Gilead, MSD, Roche, Tibotec and ViiV Healthcare outside the present work. KC has served as a speaker and as a consultant for Gilead outside the present work. RV received travel grants from Gilead, Merck and ViiVHealthCare outside the present work. JJP reports grants from ViiV Healthcare and MSD, and personal fees from Gilead, ViiV Healthcare and MSD outside the present work. RL reports grants from ViiV Healthcare, MSD, and personal fees from Gilead, ViiV Healthcare, Janssen and MSD outside the present work. SL reports personal fees from MSD outside the present work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Published
2019
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