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By January 12, 2023, more than 84,500 mpox cases and 80 deaths had been reported from 110 countries because of an ongoing multicountry outbreak (1). Cases from Europe and Americas [...]

Multiple primary malignancies in general and synchronous cancers, in particular, are relatively rare but have increased in recent decades. We report a case of a 62-year-old Vietnamese male who visited our hospital with the chief symptom was mild dysphagia. An irregular lesion causing the total luminal obstruction was detected at the low third part of the esophagus via endoscopy and two suspicious nodules in the segment V of the liver were incidentally encountered through the Computed tomography (CT). Multiple biopsies from the lesions were then performed. Histopathology and immunohistochemistry results demonstrated Squamous cell carcinoma of the esophagus and Hepatocellular carcinoma of the liver, which verified the existence of synchronous cancers in the patient.

Food coloring not only provides an attractive appearance but also aids in the quality of the food. Currently, colorants derived from natural sources, especially plants, are widely used for food coloring, with many benefits for health and the environment. This study used yellow and purple pigments extracted from Gardenia fruits and Peristrophe leaves for chemical component analysis and antioxidant and toxicity tests. Results from LC/MS analysis demonstrated that the major compounds contributing to the yellow color of the Gardenia extract and purple color of the Peristrophe extract were Crocin‐1 (C44H64O24) and Perisbivalvine B (C13H10N2O4), respectively. Moreover, the physiochemical tests showed that yellow and purple pigments were stable in a wide temperature range from 40 to 100°C. The yellow pigment was stable in a pH range of 1.0–12.0, while the purple pigment was not stable in acid media. These extracts also possessed moderate antioxidant activities with IC50 values of 0.33 g/L and 0.31 g/L for Gardenia and Peristrophe extract, respectively. In addition, toxicity tests on zebrafish embryos indicated that these extracts had low toxic activities with high LD50 values of 1.31 g/L for Gardenia extract and 0.74 g/L for Peristrophe extract. These tested extracts had also no acute toxicity on mice. Conclusively, this study provided important information about the major chemical components, which create yellow and purple colors for the Gardenia and Peristrophe extracts, and strongly suggested that the pigments extracted from Gardenia and Peristrophe can be safely used as food colorants. [ABSTRACT FROM AUTHOR]

Background: Extranodal non-Hodgkin lymphoma (NHL) is more prevalent in the gastrointestinal (GI) tract than in other sites. This study aimed to determine the endoscopic characteristics of primary gastrointestinal non-Hodgkin lymphomas. Methods: We investigated 140 patients from three tertiary referral hospitals with primary malignant lymphoma of the gastrointestinal tract. Characteristics of the lesions were evaluated and analyzed using image-enhanced endoscopy, endoscopic ultrasound, and histopathology. Results: The median age was 60.5 (range: 11–99), and 59 (42.1%) were female. The most frequent complaint was abdominal pain (74.3%), followed by bloody feces (10%) and diarrhea (2.9%). B symptoms were observed in 15 (10.7%) patients. GI obstruction was the most common complication (10.0%), followed by hemorrhage (7.9%) and perforation (1.5%). Regarding endoscopic findings, the identified sites were the following: the stomach (61.4%), colon (10%), small intestine (10%), ileocecum (8.6%), rectum (6.4%), and duodenum (3.6%). Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma are most prevalent in the stomach. Helicobacter pylori was identified in 46 cases (39.0%), with MALT lymphoma being the most infected subtype. Nearly all gastrointestinal non-Hodgkin lymphomas manifested as superficial type (25–59.6%) and ulcer type (15.6–50%) under endoscopy. We found that fungating type and protruding with ulcer type were more frequent types of aggressive lymphomas (diffuse large B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma) compared to the indolent types (MALT lymphoma, follicular lymphoma, duodenal-type follicular lymphoma, and small lymphocytic lymphoma) (p < 0.05). Conclusions: This study showed that most subtypes of gastrointestinal non-Hodgkin lymphomas exhibited same endoscopic features (superficial type and ulcer type). Aggressive gastrointestinal non-Hodgkin lymphomas (diffuse large B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma) were highly suspected when fungating lesions and protruding with ulcer lesions were encountered under endoscopy. Endoscopists should be aware of the connection between enhanced endoscopic characteristics and histological varieties of gastrointestinal lymphoma to improve diagnosis.

This paper presents the dataset that estimate the effect of factors on students’ satisfaction and their academic performance. The questionnaire with a five-Likert scale ware adapted and developed from prior researches. The sample consisted of 430 fulfilled respondents using stratified random sampling, which recruited from eight private universities in the North of Vietnam. A quantitative method was employed to examine the data. Cronbach's Alpha, Exploratory Factor Analysis, Confirmatory Factor Analysis were utilized to test the reliability and validity of each variable as well as the model fit. Then, the structural equation modeling was used to estimate path coefficients, which can serve as a good reference for further researches.