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18 results on '"Pi, Borui"'

6. Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis

Author

Hu, Peng, Sun, Jihong, Lv, Fangfang, Pi, Borui, Xu, Fangping, Han, Guocan, Hu, Xi, Wang, Yue, Huang, Ning, Wu, Xia, and Yang, Xiaoming

Subjects
MRI T1 mapping, diffusion-weighted imaging, lcsh:R, Clinical Study, image-guided biopsy, lcsh:Medicine
Abstract

Purpose To evaluate the performance of diffusion-weighted imaging (DWI) and variable flip angle (VFA) T1 mapping as a supplement to image-guided biopsy in follow-up analysis of liver fibrosis.Materials and Methods This prospective study was approved by the institution’s committee on human research, and written informed consent was provided from the enrolled patients. We investigated five MRI parameters of DWI and VFA T1 mapping, collected from 11 patients who underwent serial ultrasound image-guided biopsy with follow-up MRI within 1.5 years after treatment for liver fibrosis/cirrhosis. For each patient, four consecutive MRI examinations were conducted, including baseline MRI before treatment and three follow-up MRI examinations after treatment at each 0.5-year interval. ADC values at four b values and T1 relaxation times were correlated to pathology-confirmed liver fibrosis stages, which were subsequently divided into two groups, stages F2–3 and F4. The receiver operating characteristic (ROC) analysis and repeated measurement analysis of variance were used for statistical analysis.Results Among these ADC parameters, ADC value (b = 500 s/mm2) was the most consistent in differentiating between stage F2–3 and F4 liver fibrosis. Repeated measurement analysis showed that the intra-group and inter-group differences were 0.447 and 0.024, respectively. T1 relaxation time could not consistently differentiate between the F2–3 and F4 groups; however, it was repeatable, and the intra-group and inter-group differences were 0.410 and 0.042, respectively.Conclusion MRI-ADC value at a b value of 500 s/mm2 can be a promising biomarker for differentiating stages F2–3 and F4 liver fibrosis. A combination of this biomarker with repeatable T1 relaxation time may function as a non-invasive tool for follow-up liver fibrosis in patients who reject repeated image-guided biopsy. Keywords: image-guided biopsy, MRI T1 mapping, diffusion-weighted imaging

Published
2018

15. Characterization of the Staphylococcal Cassette Chromosome Composite Island of Staphylococcus haemolyticus SH32, a Methicillin-Resistant Clinical Isolate from China.

Author

Yu, Dongliang, Pi, Borui, Chen, Yan, Wang, Yanfei, Ruan, Zhi, Otto, Michael, and Yu, Yunsong

Subjects
*STAPHYLOCOCCAL diseases, *CHROMOSOMES, *METHICILLIN-resistant staphylococcus aureus, *MICROBIAL virulence, *NUCLEOTIDE sequence
Abstract

Staphylococcal cassette chromosome (SCC) elements contribute considerably to virulence and resistance to antibiotic agents in staphylococci. SCC elements in coagulase-negative staphylococci (CoNS) are highly diverse and there is evidence suggesting that they serve as a reservoir for antibiotic resistance genes in methicillin-resistant Staphylococcus aureus (MRSA). However, only a small number of SCC elements have been characterized in CoNS and their exact roles in the emergence and evolution of MRSA remain to be demonstrated. Here, we determined the structure of an SCC composite island (CISH32) found in the clinical Staphylococcus haemolyticus isolate SH32 by whole-genome DNA sequencing. CISH32 was 48 kb in length and mainly composed of two imperfect SCC elements, namely (i) a ΨSCCmec(SH32) part containing a class C1 mec gene complex but lacking ccr genes and (ii) a SCCSH32 part with a ccrA5B3 gene complex but lacking mec genes. In addition, CISH32 contained a type III restriction-modification system and several resistance loci, for example genes conferring resistance to cadmium and arsenic. ΨSCCmec(SH32) is almost entirely identical to a pseudo SCCmec element found in S. haemolyticus WCH1 and shares pronounced sequence similarity to a ΨSCCmec element of S. haemolyticus JCSC1435. However, staphylococci other than S. haemolyticus, including S. aureus and S. epidermidis, contain homologs of SCCSH32 that are more similar to SCCSH32 than those elements found in S. haemolyticus, suggesting that CISH32 of S. haemolyticus SH32 was assembled in recent evolutionary events. Moreover, the composite structure of CISH32 indicates that the detection of class C1 mec and ccrA5B3 gene complexes in S. haemolyticus does not always indicate the existence of a UT9-type SCCmec element, which has remained questionable. [ABSTRACT FROM AUTHOR]

Published
2014
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16. Genomic Analysis of the Multidrug-Resistant Acinetobacter baumanniiStrain MDR-ZJ06 Widely Spread in China

Author

Zhou, Hua, Zhang, Tongwu, Yu, Dongliang, Pi, Borui, Yang, Qing, Zhou, Jianying, Hu, Songnian, and Yu, Yunsong

Abstract

ABSTRACTWe previously reported that the multidrug-resistant (MDR) Acinetobacter baumanniistrain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report the whole-genome sequence of this clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) was identified in MDR-ZJ06. AbaR22 has a structure similar to those of the resistance islands found in A. baumanniistrains AYE and AB0057, but it contained only a few antibiotic resistance genes. The region of resistant gene accumulation as previously described was not found in AbaR22. In the chromosome of the strain MDR-ZJ06, we identified the gene blaoxa-23in a composite transposon (Tn2009). Tn2009shared the backbone with other A. baumanniitransponsons that harbor blaoxa-23, but it was bracketed by two ISAba1elements which were transcribed in the same orientation. MDR-ZJ06 also expressed the armAgene on its plasmid pZJ06, and this gene has the same genetic environment as the armAgene of the Enterobacteriaceae. These results suggest variability of resistance acquisition even in closely related A. baumanniistrains.

Published
2011
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17. Dual Role of gnaAin Antibiotic Resistance and Virulence in Acinetobacter baumannii

Author

Xu, Qingye, Chen, Tao, Yan, Biyong, Zhang, Linyue, Pi, Borui, Yang, Yunxing, Zhang, Linghong, Zhou, Zhihui, Ji, Shujuan, Leptihn, Sebastian, Akova, Murat, Yu, Yunsong, and Hua, Xiaoting

Abstract

Acinetobacter baumanniiis an important Gram-negative pathogen in hospital-related infections. However, treatment options for A. baumanniiinfections have become limited due to multidrug resistance. Bacterial virulence is often associated with capsule genes found in the K locus, many of which are essential for biosynthesis of the bacterial envelope. However, the roles of other genes in the K locus remain largely unknown.

Published
2019
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18. Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis.

Author

Hu P, Sun J, Lv F, Pi B, Xu F, Han G, Hu X, Wang Y, Huang N, Wu X, and Yang X

Abstract

Purpose To evaluate the performance of diffusion-weighted imaging (DWI) and variable flip angle (VFA) T1 mapping as a supplement to image-guided biopsy in follow-up analysis of liver fibrosis. Materials and Methods This prospective study was approved by the institution's committee on human research, and written informed consent was provided from the enrolled patients. We investigated five MRI parameters of DWI and VFA T1 mapping, collected from 11 patients who underwent serial ultrasound image-guided biopsy with follow-up MRI within 1.5 years after treatment for liver fibrosis/cirrhosis. For each patient, four consecutive MRI examinations were conducted, including baseline MRI before treatment and three follow-up MRI examinations after treatment at each 0.5-year interval. ADC values at four b values and T1 relaxation times were correlated to pathology-confirmed liver fibrosis stages, which were subsequently divided into two groups, stages F2-3 and F4. The receiver operating characteristic (ROC) analysis and repeated measurement analysis of variance were used for statistical analysis. Results Among these ADC parameters, ADC value (b = 500 s/mm 2 ) was the most consistent in differentiating between stage F2-3 and F4 liver fibrosis. Repeated measurement analysis showed that the intra-group and inter-group differences were 0.447 and 0.024, respectively. T1 relaxation time could not consistently differentiate between the F2-3 and F4 groups; however, it was repeatable, and the intra-group and inter-group differences were 0.410 and 0.042, respectively. Conclusion MRI-ADC value at a b value of 500 s/mm 2 can be a promising biomarker for differentiating stages F2-3 and F4 liver fibrosis. A combination of this biomarker with repeatable T1 relaxation time may function as a non-invasive tool for follow-up liver fibrosis in patients who reject repeated image-guided biopsy., (© 2018 Shanghai Journal of Interventional Medicine Press. Production and hosting by Elsevier B.V. on behalf of KeAi.)

Published
2019
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