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2. Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

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Schache, Andrew G, Shaw, Richard, Ho, Michael Wing Sung, Winter, Stuart C, Glasbey, James, Ganly, Ian, Batstone, Martin, Biel, Juan Rey, Nankivell, Paul C, Simon, Christian, Omar, Omar, Simoes, Joana F F, Nepogodiev, Dmitri, Bhangu, Aneel, Pinkney, Tom, McGill, Laura, Perry, Rita, Hughes, Terry, Jackson, Richard, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Trout, Isobel M, Venn, Mary L, Wilkin, Richard J W, Ho, Michael W S, Nankivell, Paul, Abbott, Tom E F, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Desai, Anant, Saverio, Salomone Di, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jenkinson, Michael D, Jonker, Pascal, Kaafarani, Haytham M A, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Madolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Medina, Antonio Ramos-De la, Roberts, Keith, Roslani, April C, Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Boccalatte, L A, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, D L A L, Willemse, E B M, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, E A, Carvalho, G B, Kowalski, L, Vartanian, J, Gatti, A P, Nardi, C N, Oliva, R N L, Salem, M C, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, C J, Lorencin, M, Luksic, I, Mamic, M, Ashoush, F M, Osman, N A, Safwat Shahine, M, Eldaly, A, Elfiky, M M A, Amin, A, Elmorsi, R, Refky, B, Essa, M M, Mengistu, G Mengesha, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, C S, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, J M, Greve, J, Hoffmann, T K, Laban, S, Vahl, J M, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, M D, Konney, A, Poku, M, Adjeso, T, Akornor, E T, Amankwaa, W O, Antwi, D A, Apppiah-Thompson, P, Damah, M, Kumi, E O, Manan, L, Murphy, J P, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N V, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, T A, Vassiliu, P, Kalfountzos, C E, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, D K, Sultania, M, Agarwal, S, Garg, P K, Maharaj, D D, Majumdar, K S, Mishra, N, Poonia, D, Seenivasagam, R K, Singh, M P, Tiwari, A R, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Fitzgerald, C, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, M V, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, E A, Alshareea, E A, Biala, M I, Ghmagh, R J, Ibrahim, A F, Liew, Y T, Alvarez, M R, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, C E, Becerril, O S, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, W H, Hardillo, J, de Bree, R, Schweitzer, D, Adeyeye, A A, Enoch, E E, Sholadoye, T S T T, Wuraola, F, Oyelakin, O, Khokhar, M I, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, R R, Bojicic, J M, Kovacevic, B M, Krdzic, I D, Milentijevic, M A, Milutinovic, V Z, Stefanovic, Z B, Villacampa, J M, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, F J, Jover Navalón, J M, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, U M, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, E K, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, S A, Stoeckli, S J, Simon, C, Toutounji, T, Al assaf, A, Hammed, A M, Hammed, S M, Mahfoud, M, Arikan, A, Yalkin, Ö, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert -Ulusan, M, Saracoglu, K T, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, F K, Abdel-Galil, K M A H, Lowe, T, Durrani, A J, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, S H, Segaren, N, Walker, C, Waseem, S, Jones, T M, Loh, C, Pringle, S, Schache, A G, Shaw, R J, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, S C, Hislop, S, Counter, P R, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, C K, Crank, S, Mace, A D, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, R J, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, K R, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, P R, Brennan, P, Ringrose, T, Schmidt, F, Mak, J K C, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, C G, Pigadas, N, Snee, D, Singh, R P, Hyde, N C, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, C J, Riva, F, Dickason, A, Semple, C J, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, I J, Tighe, D, Mattine, S, Chu, M M H, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, C N, Miles, B, Rapp, J, Taioli, E, Azam, M T, Choudhry, A J, Marx, W, Stein, J, Ying, Y, Gross, N D, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, Sumer, B, Department of Surgery, HUS Abdominal Center, Schache, Andrew G., Shaw, Richard, Omar, Omar, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J., Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Simoes, Joana F. F., Griffiths, Ewen A., Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, Nepogodiev, Dmitri, Kaafarani, Haytham M. A., Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Maria Aguilera, Bhangu, Aneel, Madolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Dennis, Metallidis, Symeon, Minaya-Bravo, Ana, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Pinkney, Tom, Moug, Susan, Ng-Kamstra, Joshua S., Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, McGill, Laura, Rivera, Carlos Jose Perez, Pinkney, Thomas D., van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Medina, Antonio Ramos-De la, Roberts, Keith, Roslani, April C., Rutegård, Martin, Perry, Rita, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi-Olajide, Justina O., Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Hughes, Terry, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H., Vidya, Raghavan, Vimalachandran, Dale, Jackson, Richard, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Boccalatte, L. A., Batstone, M., Hodge, R., Abeloos, J., De Backer, T., De Ceulaer, J., Dick, C., Siaw-Acheampong, Kwabena, Diez-Fraile, A., Lamoral, P., Spaas, C., Schrijvers, D. L. A. L., Willemse, E. B. M., Faris, C., Maariën, S., Van Haesendonck, G., Van Laer, C., Deron, P., Ho, Michael Wing Sung, Benson, Ruth A., Abdallah, E. A., Carvalho, G. B., Kowalski, L., Vartanian, J., Gatti, A. P., Nardi, C. N., Oliva, R. N. L., Salem, M. C., Cheng, D., MacNeil, D., Bywater, Edward, Martin, J., Mayer, R., Groot, G., Acosta, L., Mejia, M., Perez, C. J., Lorencin, M., Luksic, I., Mamic, M., Ashoush, F. M., Chaudhry, Daoud, Osman, N. A., Safwat Shahine, M., Eldaly, A., Elfiky, M. M. A., Amin, A., Elmorsi, R., Refky, B., Essa, M. M., Mengistu, G. Mengesha, Dakpé, S., Dawson, Brett E., Boucher, S., Ballouhey, Q., Laloze, J., Usseglio, J., Hoffmann, C., Gregoire, V., Lallemant, B., Blaurock, M., Reim, D., Boehm, A., Evans, Jonathan P., Guntinas-Lichius, O., Hölzle, F., Modabber, A., Winnand, P., Kleeff, J., Lorenz, K., Ronellenfitsch, U., Schneider, R., Betz, C. S., Böttcher, A., Glasbey, James C., Busch, C., Möckelmann, N., Inhestern, J. M., Greve, J., Hoffmann, T. K., Laban, S., Vahl, J. M., Agyeman-Prempeh, A., Aning, D., Barnor, I., Gujjuri, Rohan R., Darko-Asante, R., Dzogbefia, M., Gaveh, V., Gyimah, D., Issahalq, M. D., Konney, A., Poku, M., Adjeso, T., Akornor, E. T., Amankwaa, W. O., Heritage, Emily, Antwi, D. A., Apppiah-Thompson, P., Damah, M., Kumi, E. O., Manan, L., Murphy, J. P., Osei, L., Setuagbe, J., Arkadopoulos, N., Danias, N., Jones, Conor S., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N. V., Nastos, K., Parasyris, S., Pikoulis, E., Selmani, J., Sidiropoulos, T. A., Kamarajah, Sivesh K., Vassiliu, P., Kalfountzos, C. E., Chatziioannou, I., Corais, C., Gkrinia, E., Ntziovara, A., Saratziotis, A., Antoniadis, K., Orestis, O., Tatsis, D., Winter, Stuart C., Khatri, Chetan, Baili, E., Charalabopoulos, A., Liakakos, T., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Aguilera-Arévalo, M., Misra, S., Pareek, P., Khaw, Rachel A., Vishnoi, J., Chappity, P., Kar, M., Muduly, D. K., Sultania, M., Agarwal, S., Garg, P. K., Maharaj, D. D., Majumdar, K. S., Mishra, N., Keatley, James M., Poonia, D., Seenivasagam, R. K., Singh, M. P., Tiwari, A. R., Penumadu, P., Rajan, S., Kumar, S., Raychowdhury, R., Ghodke, R., Knight, Andrew, Barry, C., Callanan, D., Dias, A., Haung, L., Ionescu, A., Sheahan, P., Lennon, P., Fitzgerald, C., Mizrachi, A., Deganello, A., Lawday, Samuel, Pellini, R., Pichi, B., Lemma, F., Marino, M. V., Bergonzani, M., Varazzani, A., Bussu, F., Perra, T., Piras, A., Porcu, A., Li, Elizabeth, Rizzo, D., Campisi, G., Cordova, A., Franza, M., Rinaldi, G., Toia, F., Gianni, A., Giannini, L., Gordini, L., Baldini, E., Mann, Harvinder S., Conti, L., De Virgilio, A., Ferreli, F., Gaino, F., Mercante, G., Spriano, G., Ansarin, M., Chu, F., De Berardinis, R., Ietrobon, G., Marson, Ella J., Tagliabue, M., Ionna, F., Baietti, A., Maremonti, P., Neri, F., Prucher, G., Ricci, S., Casaril, A., Nama, M., Cotoia, A., McLean, Kenneth A., Lizzi, V., Vovola, F., Bruzzaniti, P., Familiari, P., Lapolla, P., Marruzzo, G., Mingoli, A., Ribuffo, D., Cipriani, R., Contedini, F., Mckay, Siobhan C., Lauretta, M., Marchetti, C., Melotti, M., Pignatti, M., Pinto, V., Pizzigallo, A., Ricotta, F., Tarsitano, A., Catarzi, L., Abdulwahed, E. A., Glasbey, James, Mills, Emily C., Alshareea, E. A., Biala, M. I., Ghmagh, R. J., Ibrahim, A. F., Liew, Y. T., Alvarez, M. R., Arrangoiz, R., Cordera, F., Gómez-Pedraza, A., Soulé-Martínez, C. E., Becerril, O. S., Becerra, Gfc, Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M., Benkabbou, A., Majbar, M., Mohsine, R., Souadka, A., Pellino, Gianluca, Lageju, N., Schreuder, W. H., Hardillo, J., de Bree, R., Schweitzer, D., Adeyeye, A. A., Enoch, E. E., Sholadoye, T. S. T. T., Wuraola, F., Oyelakin, O., Picciochi, Maria, Khokhar, M. I., Ayub, B., Walędziak, M., Szewczyk, M., Faria, C., Cardoso, P., Castro Silva, J., AlKharashi, E., Jelovac, D., Petrovic, M., Taylor, Elliott H., Sumrak, S., Asceric, R. R., Bojicic, J. M., Kovacevic, B. M., Krdzic, I. D., Milentijevic, M. A., Milutinovic, V. Z., Stefanovic, Z. B., Villacampa, J. M., Jiménez Carneros, V., Tiwari, Abhinav, Salazar Carrasco, A., Carabias Hernandez, A., Alonso Lamberti, L., León Ledesma, R., Jiménez Miramón, F. J., Jover Navalón, J. M., Garcia Quijada, J., Ramos Rodriguez, J., Valle Rubio, A., Vilaseca, I., Escartin, J., Estaire-Gomez, M., Padilla Valverde, D., Tousidonis, M., Lopez, F., Deandrés-Olabarria, U., Durán-Ballesteros, M., Fernández-Pablos, F., Ibáñez-Aguirre, F., Sanz-Larrainzar, A., Trout, Isobel M., Ugarte-Sierra, B., Di Martino, M., Prada, J., Jariod-Ferrer, U. M., Landaluce Olavarria, A., Rey-Biel, J., Díaz de Cerio, P., Sánchez Barrueco, A., Lindqvist, E. K., Sund, M., Venn, Mary L., Piantanida, R., Giger, R., Hool, S., Müller, S. A., Stoeckli, S. J., Simon, C., Toutounji, T., Al Assaf, A., Hammed, A. M., Hammed, S. M., Wilkin, Richard J. W., Mahfoud, M., Arikan, A., Yalkin, Ö, İflazoğlu, N., Isik, A., Leventoglu, S., Aydemir, L., Basaran, B., Sen, C., Comert-Ulusan, M., Ganly, Ian, Saracoglu, K. T., Saracoglu, A., Mantoglu, B., Kucuk, G., Aygun, N., Baran, E., Tanal, M., Eray Tufan, A., Uludag, M., Gürkan Yetkin, S., Yigit, B., Calik, B., Demirli Atici, S., Kaya, T., Sikakulya, F. K., Abdel-Galil, K. M. A. H., Lowe, T., Durrani, A. J., Habeeb, A., Irune, E., Luke, L., Masterson, L., Murphy, S. H., Segaren, N., Walker, C., Waseem, S., Jones, T. M., Loh, C., Pringle, S., Schache, A. G., Shaw, R. J., Stenhouse, J., Armstrong, M., Sood, S., Sutton, D., Thomas, S., Clarke, P., Winter, S. C., Hislop, S., Counter, P. R., Ghazali, N., Lloyd, C., Prabhu, V., Godden, D., Whitley, S., Butler, C., Nash, R., El-Boghdadly, K., Fry, A., Ho, Michael W. S., Niziol, R., De, M., Gill, C. K., Crank, S., Mace, A. D., Ho, M., Mair, M., Kothari, P., Homer, J., Sainuddin, S., Nankivell, Paul, Egan, R. J., Kittur, M., Burgess, C., O'Hara, J., Manickavasagam, J., McDonald, C., Burrows, S., Java, K. R., Katre, C., Ahmed, A., Biel, Juan Rey, Siddique, H., King, E., Ramchandani, P., Naredla, P. R., Brennan, P., Ringrose, T., Schmidt, F., Mak, J. K. C., Nankivell, P., Parmar, S., Batstone, Martin, Sharma, N., Douglas, C., McCaul, J., Dhanda, J., Kyzas, P., Vassiliou, L., Kumar, A., Husband, A., Hulbert, J., Ingrams, D., Parkin, R., Varley, I., Gahir, D., George, A., Zakai, D., Bater, M., Surwald, C., Devlin, B., Simon, Christian, Leonard, C. G., Pigadas, N., Snee, D., Singh, R. P., Hyde, N. C., Paley, M., Cocks, H., Wilson, A., Choi, D., Kerawala, C. J., Riva, F., Dickason, A., Semple, C. J., Schilling, C., Walton, G., Rees-Stoner, O., Scott, N., Nixon, I. J., Tighe, D., Abbott, Tom E. F., Mattine, S., Chu, M. M. H., Pothula, V., Lee, W., Brown, L., Ganly, I., Alpert, N., Illezeau, C. N., Miles, B., Rapp, J., Adamina, Michel, Taioli, E., Azam, M. T., Choudhry, A. J., Marx, W., Stein, J., Ying, Y., Gross, N. D., Almasri, M., Joshi, R., Kulkarni, G., Ademuyiwa, Adesoji O., Marwan, H., Mehdi, M., Sumer, B., Consorti, Giuseppe, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K., Barlow, Emma, Nankivell, Paul C., Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A., Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Di Saverio, Salomone, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Collaborative, COVIDSurg, COVIDSurg Collaborative, EuroSurg, European Soc Coloproctology ESCP, Global Initiative Childrens Surg G, GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Soc Colorectal Surg SICCR, Assoc Surg Training ASiT, Irish Surg Res Collaborative ISRC, Transatlantic Australasian Retrope, Italian Soc Surg Oncology SICO, Schache, Andrew G, Winter, Stuart C, Glasbey, Jame, Nankivell, Paul C, Simoes, Joana F F, Benson, Ruth A, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Jones, Conor S, Kamarajah, Sivesh K, Khaw, Rachel A, Keatley, James M, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Taylor, Elliott H, Trout, Isobel M, Venn, Mary L, Wilkin, Richard J W, Ho, Michael W S, Abbott, Tom E F, Ademuyiwa, Adesoji O, Albertsmeiers, Marku, Arnaud, Alexis P, Ayasra, Fari, Bankhead-Kendall, Brittany K, Breen, Kerry A, Bretherton, Chri, Caruana, Edward J, Cukier, Moise, Cunha, Miguel F, Davidson, Giana H, Saverio, Salomone Di, Drake, Thomas M, Edwards, John G, Edward Fitzgerald, J, Griffiths, Ewen A, Harrison, Ewen M, Hutchinson, Peter J, Jenkinson, Michael D, Kaafarani, Haytham M A, Kolias, Angelo, Lederhuber, Han, Löffler, Markus W, Mashbari, Hassan N, Mazingi, Denni, Mohan, Helen M, Ng-Kamstra, Joshua S, Niquen, Milagro, Pinkney, Thomas D, Roslani, April C, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Stewart, Grant D, Tsoulfas, Georgio, van Ramshorst, Gabrielle H, Warren, Oliver J, Boccalatte, L A, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, D L A L, Willemse, E B M, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, E A, Carvalho, G B, Kowalski, L, Vartanian, J, Gatti, A P, Nardi, C N, Oliva, R N L, Salem, M C, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, C J, Lorencin, M, Luksic, I, Mamic, M, Ashoush, F M, Osman, N A, Safwat Shahine, M, Eldaly, A, Elfiky, M M A, Amin, A, Elmorsi, R, Refky, B, Essa, M M, Mengistu, G Mengesha, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, C S, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, J M, Greve, J, Hoffmann, T K, Laban, S, Vahl, J M, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, M D, Konney, A, Poku, M, Adjeso, T, Akornor, E T, Amankwaa, W O, Antwi, D A, Apppiah-Thompson, P, Damah, M, Kumi, E O, Manan, L, Murphy, J P, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N V, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, T A, Vassiliu, P, Kalfountzos, C E, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, D K, Sultania, M, Agarwal, S, Garg, P K, Maharaj, D D, Majumdar, K S, Mishra, N, Poonia, D, Seenivasagam, R K, Singh, M P, Tiwari, A R, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Fitzgerald, C, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, M V, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, E A, Alshareea, E A, Biala, M I, Ghmagh, R J, Ibrahim, A F, Liew, Y T, Alvarez, M R, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, C E, Becerril, O S, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, W H, Hardillo, J, de Bree, R, Schweitzer, D, Adeyeye, A A, Enoch, E E, Sholadoye, T S T T, Wuraola, F, Oyelakin, O, Khokhar, M I, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, R R, Bojicic, J M, Kovacevic, B M, Krdzic, I D, Milentijevic, M A, Milutinovic, V Z, Stefanovic, Z B, Villacampa, J M, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, F J, Jover Navalón, J M, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, U M, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, E K, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, S A, Stoeckli, S J, Simon, C, Toutounji, T, Al assaf, A, Hammed, A M, Hammed, S M, Mahfoud, M, Arikan, A, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert -Ulusan, M, Saracoglu, K T, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, F K, Abdel-Galil, K M A H, Lowe, T, Durrani, A J, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, S H, Segaren, N, Walker, C, Waseem, S, Jones, T M, Loh, C, Pringle, S, Schache, A G, Shaw, R J, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, S C, Hislop, S, Counter, P R, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, C K, Crank, S, Mace, A D, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, R J, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, K R, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, P R, Brennan, P, Ringrose, T, Schmidt, F, Mak, J K C, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, C G, Pigadas, N, Snee, D, Singh, R P, Hyde, N C, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, C J, Riva, F, Dickason, A, Semple, C J, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, I J, Tighe, D, Mattine, S, Chu, M M H, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, C N, Miles, B, Rapp, J, Taioli, E, Azam, M T, Choudhry, A J, Marx, W, Stein, J, Ying, Y, Gross, N D, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, and Sumer, B

Subjects
AcademicSubjects/MED00910, SARS-CoV-2, pandemic, COVID-19, safe healthcare delivery, education, Bjs/2, General Medicine, 030230 surgery, 3126 Surgery, anesthesiology, intensive care, radiology, 3. Good health, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, parasitic diseases, Research Letter, Humans, head and neck cancer, Human medicine, AcademicSubjects/MED00010, COVID
Abstract

BJS open 5(6), zrab112 (2021). doi:10.1093/bjsopen/zrab112, Published by Oxford University Press, Oxford

Published
2021

3. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

Author

Perruzza, L, Jaconi, S, Lombardo, G, Pinna, D, Strati, F, Morone, D, Seehusen, F, Hu, Y, Bajoria, S, Xiong, J, Kumru, O, Joshi, S, Volkin, D, Piantanida, R, Benigni, F, Grassi, F, Corti, D, Pizzuto, M, Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru O.S, Joshi S.B, Volkin D.B, Piantanida R, Benigni F, Grassi F, Corti D, Pizzuto M.S., Perruzza, L, Jaconi, S, Lombardo, G, Pinna, D, Strati, F, Morone, D, Seehusen, F, Hu, Y, Bajoria, S, Xiong, J, Kumru, O, Joshi, S, Volkin, D, Piantanida, R, Benigni, F, Grassi, F, Corti, D, Pizzuto, M, Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru O.S, Joshi S.B, Volkin D.B, Piantanida R, Benigni F, Grassi F, Corti D, and Pizzuto M.S.

Abstract

Campylobacter infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. In this study, we describe the prophylactic activity of orally delivered recombinant SIgA generated from two human monoclonal antibodies (CAA1 and CCG4) isolated for their reactivity against the flagellar-capping protein FliD, which is essential for bacteria motility and highly conserved across Campylobacter species associated with severe enteritis. In an immunocompetent weaned mouse model, a single oral administration of FliD-reactive SIgA CAA1 or CCG4 at 2 h before infection significantly enhances Campylobacter clearance at early stages post-infection, reducing the levels of inflammation markers associated with epithelial damage and polymorphonuclear (PMN) cells infiltration in the cecum lamina propria. Our data indicate that the prophylactic activity of CAA1 and CCG4 is not only dependent on the specificity to FliD but also on the use of the SIgA format, as the immunoglobulin G (IgG) versions of the same antibodies did not confer a comparable protective effect. Our work emphasizes the potential of FliD as a target for the development of vaccines and supports the concept that orally administered FliD-reactive SIgA can be developed to prevent or mitigate the severity of Campylobacter infections as well as the development of post-infection syndromes.

Published
2020

4. UK Head and neck cancer surgical capacity during the second wave of the COVID-19 pandemic: Have we learned the lessons? COVIDSurg collaborative

Author

Shaw, Richard, Schache, Andrew G, Ho, Michael Wing Sung, Winter, Stuart C, Glasbey, James, Ganly, Ian, Batstone, Martin, Biel, Juan Rey, Nankivell, Paul C, Simon, Christian, Omar, Omar, Simoes, Joana FF, Nepogodiev, Dmitri, Bhangu, Aneel, Pinkney, Tom, McGill, Laura, Perry, Rita, Hughes, Terry, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Ho, Michael WS, Nankivell, Paul, Abbott, Tom EF, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Lima Buarque, Igor, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Desai, Anant, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jenkinson, Michael D, Jonker, Pascal, Kaafarani, Haytham MA, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Aguilera Lorena, Maria, Marta Madolo, Maria, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April C, Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O., Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Boccalatte, LA, Batstone, M, Hodge, R, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Schrijvers, DLAL, Willemse, EBM, Faris, C, Maariën, S, Van Haesendonck, G, Van Laer, C, Deron, P, Abdallah, EA, Carvalho, GB, Kowalski, L, Vartanian, J, Gatti, AP, Nardi, CN, Oliva, RNL, Salem, MC, Cheng, D, MacNeil, D, Martin, J, Mayer, R, Groot, G, Acosta, L, Mejia, M, Perez, CJ, Lorencin, M, Luksic, I, Mamic, M, Ashoush, FM, Osman, NA, Safwat Shahine, M, Eldaly, A, Elfiky, MMA, Amin, A, Elmorsi, R, Refky, B, Essa, MM, Mengesha, Mengistu G, Dakpé, S, Boucher, S, Ballouhey, Q, Laloze, J, Usseglio, J, Hoffmann, C, Gregoire, V, Lallemant, B, Blaurock, M, Reim, D, Boehm, A, Guntinas-Lichius, O, Hölzle, F, Modabber, A, Winnand, P, Kleeff, J, Lorenz, K, Ronellenfitsch, U, Schneider, R, Betz, CS, Böttcher, A, Busch, C, Möckelmann, N, Inhestern, JM, Greve, J, Hoffmann, TK, Laban, S, Vahl, JM, Agyeman-Prempeh, A, Aning, D, Barnor, I, Darko-Asante, R, Dzogbefia, M, Gaveh, V, Gyimah, D, Issahalq, MD, Konney, A, Poku, M, Adjeso, T, Akornor, ET, Amankwaa, WO, Antwi, DA, Apppiah-Thompson, P, Damah, M, Kumi, EO, Manan, L, Murphy, JP, Osei, L, Setuagbe, J, Arkadopoulos, N, Danias, N, Economopoulou, P, Frountzas, M, Kokoropoulos, P, Larentzakis, A, Michalopoulos, NV, Nastos, K, Parasyris, S, Pikoulis, E, Selmani, J, Sidiropoulos, TA, Vassiliu, P, Kalfountzos, CE, Chatziioannou, I, Corais, C, Gkrinia, E, Ntziovara, A, Saratziotis, A, Antoniadis, K, Orestis, O, Tatsis, D, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Aguilera-Arévalo, M, Misra, S, Pareek, P, Vishnoi, J, Chappity, P, Kar, M, Muduly, DK, Sultania, M, Agarwal, S, Garg, PK, Maharaj, DD, Majumdar, KS, Mishra, N, Poonia, D, Seenivasagam, RK, Singh, MP, Tiwari, AR, Penumadu, P, Rajan, S, Kumar, S, Raychowdhury, R, Ghodke, R, Barry, C, Callanan, D, Dias, A, Haung, L, Ionescu, A, Sheahan, P, Lennon, P, Mizrachi, A, Deganello, A, Pellini, R, Pichi, B, Lemma, F, Marino, MV, Bergonzani, M, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Gianni, A, Giannini, L, Gordini, L, Baldini, E, Conti, L, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Spriano, G, Ansarin, M, Chu, F, De Berardinis, R, Ietrobon, G, Tagliabue, M, Ionna, F, Baietti, A, Maremonti, P, Neri, F, Prucher, G, Ricci, S, Casaril, A, Nama, M, Cotoia, A, Lizzi, V, Vovola, F, Bruzzaniti, P, Familiari, P, Lapolla, P, Marruzzo, G, Mingoli, A, Ribuffo, D, Cipriani, R, Contedini, F, Lauretta, M, Marchetti, C, Melotti, M, Pignatti, M, Pinto, V, Pizzigallo, A, Ricotta, F, Tarsitano, A, Catarzi, L, Consorti, G, Abdulwahed, EA, Alshareea, EA, Biala, MI, Ghmagh, RJ, Ibrahim, AF, Liew, YT, Alvarez, MR, Arrangoiz, R, Cordera, F, Gómez-Pedraza, A, Soulé-Martínez, CE, Becerril, OS, Becerra, GFC, Arkha, Y, Bechri, H, El Ouahabi, A, Oudrhiri, M, Benkabbou, A, Majbar, M, Mohsine, R, Souadka, A, Lageju, N, Schreuder, WH, Hardillo, J, Bree, R, Schweitzer, D, Adeyeye, AA, Enoch, EE, Sholadoye, TSTT, Wuraola, F, Oyelakin, O, Khokhar, MI, Ayub, B, Walędziak, M, Szewczyk, M, Faria, C, Cardoso, P, Castro Silva, J, AlKharashi, E, Jelovac, D, Petrovic, M, Sumrak, S, Asceric, RR, Bojicic, JM, Kovacevic, BM, Krdzic, ID, Milentijevic, MA, Milutinovic, VZ, Stefanovic, ZB, Villacampa, JM, Jiménez Carneros, V, Salazar Carrasco, A, Carabias Hernandez, A, Alonso Lamberti, L, León Ledesma, R, Jiménez Miramón, FJ, Jover Navalón, JM, Garcia Quijada, J, Ramos Rodriguez, J, Valle Rubio, A, Vilaseca, I, Escartin, J, Estaire-Gomez, M, Padilla Valverde, D, Tousidonis, M, Lopez, F, Deandrés-Olabarria, U, Durán-Ballesteros, M, Fernández-Pablos, F, Ibáñez-Aguirre, F, Sanz-Larrainzar, A, Ugarte-Sierra, B, Di Martino, M, Prada, J, Jariod-Ferrer, UM, Landaluce Olavarria, A, Rey-Biel, J, Díaz de Cerio, P, Sánchez Barrueco, A, Lindqvist, EK, Sund, M, Piantanida, R, Giger, R, Hool, S, Müller, SA, Stoeckli, SJ, Simon, C, Toutounji, T, Al assaf, A, Hammed, AM, Hammed, SM, Mahfoud, M, Arikan, A, Yalkin, Ö, İflazoğlu, N, Isik, A, Leventoglu, S, Aydemir, L, Basaran, B, Sen, C, Comert-Ulusan, M, Saracoglu, KT, Saracoglu, A, Mantoglu, B, Kucuk, G, Aygun, N, Baran, E, Tanal, M, Eray Tufan, A, Uludag, M, Gürkan Yetkin, S, Yigit, B, Calik, B, Demirli Atici, S, Kaya, T, Sikakulya, FK, Abdel-Galil, KMAH, Lowe, T, Durrani, AJ, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, SH, Segaren, N, Walker, C, Waseem, S, Jones, TM, Loh, C, Pringle, S, Schache, AG, Shaw, RJ, Stenhouse, J, Armstrong, M, Sood, S, Sutton, D, Thomas, S, Clarke, P, Winter, SC, Hislop, S, Counter, PR, Ghazali, N, Lloyd, C, Prabhu, V, Godden, D, Whitley, S, Butler, C, Nash, R, El-Boghdadly, K, Fry, A, Niziol, R, De, M, Gill, CK, Crank, S, Mace, AD, Ho, M, Mair, M, Kothari, P, Homer, J, Sainuddin, S, Egan, RJ, Kittur, M, Burgess, C, O'Hara, J, Manickavasagam, J, McDonald, C, Burrows, S, Java, KR, Katre, C, Ahmed, A, Siddique, H, King, E, Ramchandani, P, Naredla, PR, Brennan, P, Ringrose, T, Schmidt, F, Mak, JKC, Nankivell, P, Parmar, S, Sharma, N, Douglas, C, McCaul, J, Dhanda, J, Kyzas, P, Vassiliou, L, Kumar, A, Husband, A, Hulbert, J, Ingrams, D, Parkin, R, Varley, I, Gahir, D, George, A, Zakai, D, Bater, M, Surwald, C, Devlin, B, Leonard, CG, Pigadas, N, Snee, D, Singh, RP, Hyde, NC, Paley, M, Cocks, H, Wilson, A, Choi, D, Kerawala, CJ, Riva, F, Dickason, A, Semple, CJ, Schilling, C, Walton, G, Rees-Stoner, O, Scott, N, Nixon, IJ, Tighe, D, Mattine, S, Chu, MMH, Pothula, V, Lee, W, Brown, L, Ganly, I, Alpert, N, Illezeau, CN, Miles, B, Rapp, J, Taioli, E, Azam, MT, Choudhry, AJ, Marx, W, Stein, J, Ying, Y, Gross, ND, Almasri, M, Joshi, R, Kulkarni, G, Marwan, H, Mehdi, M, Sumer, B, Collaborative, COVIDSurg, and Winter, SC

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), delay, medicine.medical_treatment, Comorbidity, SARS‐CoV‐2, surgery, Tertiary Care Centers, Patient referral, COVID‐19, Pandemic, medicine, Humans, Current wave, Pandemics, SARS-CoV-2, business.industry, capacity, pandemic, General surgery, Head and neck cancer, COVID-19, Original Articles, medicine.disease, United Kingdom, Otorhinolaryngologic Surgical Procedures, critical care, Radiation therapy, head and neck cancer, comorbidity, head and neck neoplasms, humans, otorhinolaryngologic surgical procedures, tertiary care centers, Otorhinolaryngology, Head and Neck Neoplasms, Original Article, business, Cancer surgery
Abstract

Objectives: The aim of this study was to evaluate the differences in surgical capacity for head and neck cancer in the UK between the first wave (March‐June 2020) and the current wave (Jan‐Feb 2021) of the COVID‐19 pandemic. Design: REDcap online based survey of hospital capacity. Setting: UK secondary and tertiary hospitals providing head and neck cancer surgery. Participants: One representative per hospital was asked to report the capacity for head and neck cancer surgery in that institution. Main Outcome Measures: The principal measures of interests were new patient referrals, capacity in outpatients, theatres and critical care; therapeutic compromises constituting delay to surgery, de‐escalated surgery and therapeutic migration to non‐surgical primary modality. Results: Data was returned from approximately 95% of UK hospitals with a head and neck cancer surgery specialist service. 50% of UK head and neck cancer patients requiring surgery have significantly compromised treatments during the second wave: 28% delayed, 10% have received radiotherapy‐based treatment instead of surgery and 12% have received de‐escalated surgery. Surgical capacity has been more severely constrained in the second wave (58% of pre‐pandemic level) compared with the first wave (62%) despite the time to prepare. Conclusions: Some hospitals are overwhelmed by COVID‐19 and unable to offer essential cancer surgery, but all have neighbouring hospitals in their region retaining good (or even normal) capacity. It is noteworthy that very few patients have been appropriately re‐directed away from the hospitals most constrained by their burden of COVID‐19. The paucity of an effective central or regional strategic response to this evident mismatch between demand and surgical capacity is to the detriment of our head and neck cancer patients.

Published
2021

9. Injuries due to foreign body aspirations in Georgia: A prevention perspective

Author

Gvetadze, P. Chkhaidze, I. Baldas, S. Comoretto, R. Gregori, D. Berchialla, P. Rodriguez, H. Zaupa, P. Spitzer, P. Demetriades, C. Slapák, I. Sokolova, L. Petridou, E. Antonio Caldeira Pais Clemente, M. Jakubíková, J. Van As, S. De Koning, T. Passali, D. Cuestas, G. Bouchikhi, N. Chinsky, A. Ro, H. Tortosa, S. Alassia, O. Abete, F. Sica, G. Di Blasio, A. Rodríguez, V. Taire, D. Paoli, B. Rene Marquez, C. Razetti, J. Adolfo Mariotti, C. Héctor Ariel, A. Zanetta, A. Dario, F. Milena Pabón, S. Quijano, A. Elena Nieto, M. Villca, N. Brkic, F. Reis, M. Manrique, D. Nkodo, Y. Ludemann, J. Cheng peng, J. Barón Puentes, O.U. Mladina, R. Gomez De La Rosa, E. Kalakouta, O. eas Melis, A. Zeitouni, F. Máchalová, M. Slapak, J. Pecková, P. Caye-Thomasen, P. Silva Chacon, F. Parker, J. Elsheikh, E. Ragab, A. Pitkäranta, A. Contencin Necker, P. Derelle, J. Duwelz, M. Francois, M. Pezzettigotta, S. Righini, C. Buzarov, J. Bernhard, R. Jahnke, V. Onder, G. Zieriacks, P. Siegfried, K. Koitschev, A. Kalampoki, V. Simasko, N. Skoulakis, C. Gulati, A. Camaioni, A. Cutrone, C. Gaudini, E. Grasso, D. Mansi, N. Messi, G. Orlando, C. Preziosi, S. Sorrentini, I. Trozzi, M. o Vigo, A. Villari, G. Cesare Passali, G. Maria Passali, F. Piantanida, R. Giordano, C. Mercuri, L. Cecconi, A. Giovari, M. Nishida, Y. Ussatayeva, G. Antonio De Hoyos Parra, R. Gonzalez, J.L. Eleuterio Gonzá lez, J. Emmanuel Ologe, F. Nasrullah, M. Melendez, A. Milanes, R. Chmielik, M. Belchior, T. Dan Cobzeanu, M. Cristian Gheorghe, D. Iorgulescu, A. Caius-Codrut Toader, M. Barkociová, J. Havelkova, B. Janka Koman, A. Zargi, M. Pumarola, F. Rubio, L. Perniás Peco, K. Stierna, P. Hsu, W. Arj-Ong, S. Chomchai, C. Chotigavanich, C. Hoep, L. Rinkel, R. Berraies, A. Aydin Baskent, E. Sarper Erikci, V. Onerci, M. Graham, J. Khwaja, S. Raine, C. Haloob, N. Doassans Goḿez Haedo, I. Mehta, D. Casselbrant, M. Susy Safe Working Group

Abstract

Background: Suffocation due to foreign bodies (FB) is a leading cause of death in children aged 0-3. No data from the former U.S.S.R. are available in the international scientific literature. Methods: Consecutive patients admitted at the Iashvili Central Children Hospital in Tbilisi, Georgia from 1989 to 2011 were analyzed. Injuries in the upper airways due to foreign bodies' inhalation were collected and compared with the Susy Safe Registry and the pooled estimates of the meta-analysis. Results: 2896 cases were collected. Distribution of injuries in children younger than 3 years was significantly higher than in the Susy Safe Registry and in the "High-Income" countries in the meta-analysis. Percentage of injuries due to organic objects (86%) was significantly higher than in published data. Conclusions: Since Georgia is not showing any substantial difference, both in epidemiology and treatment of foreign bodies injuries, as compared to the other case series, translation of public health initiatives from other most advanced prevention experiences is possible and it is likely to be effective. Level of evidence: Level V, Epidemiological case series. © 2015 Elsevier Ireland Ltd.

Published
2016

10. Symptoms associated with button batteries injuries in children: An epidemiological review

Author

Buttazzoni, E. Gregori, D. Paoli, B. Soriani, N. Baldas, S. Rodriguez, H. Lorenzoni, G. Marquez, C.R. Cuestas, G. Sica, G. Berchialla, P. Zaupa, P. Spitzer, P. Demetriades, C. Ŝlapák, I. Sokolova, L. Petridou, E. Antonio, M. Jakubíková, J. As, S.V. Koning, T.D. Passali, D. Bouchikhi, N. Boufersaoui, A. Chinsky, A. Tortosa, S. Blasio, A.D. Rodríguez, V. Taire, D. Razetti, J. Mariotti, C.A. Ariel, A.H. Zanetta, A. Dario, F. Pabón, S.M. Quijano, A. Nieto, M.E. Bordino, L. Dallakyan, N. Dallakyan, D. Villca, N. Brkic, F. Umihanic, S. Reis, M. Manrique, D. Nkodo, Y. Ludemann, J. Chengpeng, J. Puentes, O.U.B. Mladina, R. De La Rosa, E.G. Kalakouta, O. Melis, A. Zeitouni, F. Máchalová, M. Slapak, J. Pecková, P. Caye-Thomasen, P. Chacon, F.S. Parker, J. Elsheikh, E. Ragab, A. Pitkäranta, A. Necker, P.C. Derelle, J. Duwelz, M. Francois, M. Pezzettigotta, S. Righini, C. Chkhaidze, I. Bernhard, R. Jahnke, V. Onder, G. Zieriacks, P. Siegfried, K. Koitschev, A. Kalampoki, V. Simasko, N. Skoulakis, C. Gulati, A. Nimbalkar, S. Sharma, Y. Squicciarini, M. Damasco, M. Camaioni, A. Cutrone, C. Gaudini, E. Grassom, D. Messi, G. Mansi, N. Orlando, C. Preziosi, S. Sorrentini, I. Villari, G. Trozzi, M. Vigo, A. Passali, G.C. Passali, F.M. Piantanida, R. Giordano, C. Mercuri, L. Cecconi, A. Giovari, M. Calderini, E. Nishida, Y. Saito, T. Ussatayeva, G. De Hoyos Parra, R.A. Treviño Gonzalez, J.L. Ramayo, S. Ologe, F.E. Afolabi, O. Nasrullah, M. Melendez, A. Milanes, R. Chmielik, M. Belchior, T. Cobzeanu, M.D. Gheorghe, D.C. Iorgulescu, A. Toader, M. Codrut, C. Stankovic, K. Barkociová, J. Havelkova, B. Jakubikova, J. Koman, A. Zargi, M. Pumarola, F. Rubio, L. Peco, K.P. Stierna, P. Hsu, W.-C. Arj-Ong, S. Chomchai, C. Chotigavanich, C. Hoep, L. Rinkel, R. Berraies, A. Baskent, E.A. Erikci, V.S. Onerci, M. Graham, J. Khwaja, S. Raine, C. Haloob, N. Haedo, I.D.G. Mehta, D. Casselbrant, M. Toan, P.N. The Susy Safe Working Group

Abstract

Objectives: To provide an epidemiological framework of symptoms related to Foreign Body (FB) injuries due to Button Battery (BB). Methods: Data on BB ingestion/inhalation have been obtained from the ButtonBatteryDB. The ButtonBatteryDB is a database collecting information on BB injuries in children (0-18 years of age). Data on 348 BB injures have been derived from the Registry of Foreign Body Injuries "Susy Safe" (269 cases) and from published scientific literature reporting case reports of FB injuries (79 cases). Results: Most of injured children were male and BBs were found more often in the mouth/esophagus/stomach (ICD935) and in the nose (ICD932). Analyzing symptoms related to BB located in the esophagus/mouth/stomach, we found that children had higher probability of experiencing dysphagia (30.19%, 95% C.I. 17.83-42.55), fever and cough (26.42%, 95% C.I. 14.55-38.28), compared to the other symptoms. Referring to the probability that symptoms occurred simultaneously, fever and cough are more likely (3.72%, 95% C.I. 1.0-6-43) to jointly showing up in children with BB in mouth/esophagus/stomach (ICD935), followed by fever and dysphagia (2.66%, 95% C.I. 0.36-4.96) and by fever and irritability/crying, fever and drooling, dysphagia and irritability/crying (2.13% C.I. 0.00-4.19, 95% C.I.). Conclusions: These findings provide new insight in clinical presentation of BB injuries: the identification of unique patterns of symptoms related to BB injuries is useful to perform an early diagnosis (and to guarantee a prompt medical reaction), also when the injury is un-witnessed. © 2015 Elsevier Ireland Ltd.

Published
2015

11. 18F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging.

Author

Paone, G., Martucci, F., Espeli, V., Ceriani, L., Treglia, G., Ruberto, T., Richetti, A., Piantanida, R., and Giovanella, L.

Abstract

This study assessed the role of 18F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or magnetic resonance). In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in terms of event-free survival (EFS) and overall survival (OS). We retrospectively analyzed 27 patients with glottic squamous cell carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and radiotherapy planning, and CI findings. Cohen's K was used to compare concordance between PET/CT and CI. Imaging findings were correlated with endoscopic evaluation and histological reports (gold standard (GS)). All lesions shown by CI were also detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT). Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively. MRI showed sensitivity and specificity of 100%. One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/CT with no difference compared to MRI (10 cases). Six FN cases and 1 FP case were observed with CT. Cohen's K was 0.60 (PET vs. CI) and 0.80 (PET vs. GS). Patients were followed-up for at least 24 months to calculate EFS and OS. 13 local recurrence and 7 deaths were recorded. Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome. Our data suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local staging in addition to the well-established role in lymph-node and distant sites assessment. Furthermore, pretreatment MTV provides better prognostic information than other PET/CT parameters. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy

Author

Spriano, G., Antognoni, P., Sanguineti, G., Sormani, M., Richetti, A., Ameli, F., Piantanida, R., Luraghi, R., Magli, A., Corvo, R., Tordiglione, M., and Vitale, V.

Abstract

Purpose:: This study was performed to investigate factors associated with laryngeal morbidity when postoperative radiation therapy (RT) is added to supraglottic laryngectomy. Materials and Methods:: From 1980 to 1994, 56 patients affected with T1 to 4 N0 to 2c supraglottic squamous cell carcinoma selected for standard (59%) or extended (41%) supraglottic laryngectomy at 2 different institutions were retrospectively analyzed. Most of the patients (91%) also underwent neck dissection. Approximately 80% of the patients had stage T4 primary lesions or N2 neck disease. Postoperative RT was added for presumed microscopic disease at the primary site (13 patients), regional nodes (23 patients), or both (20 patients). Median delivered doses to the larynx and to the neck were 50 Gy (range, 40 to 64 Gy) and 46 Gy (range, 40 to 64 Gy), respectively. Median follow-up for living patients is 11 years (range, 2.8 to 16.9 years). Laryngeal complication was defined as the appearance of grade 2 or higher toxicity according to the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) scoring systems. Results:: Two- and 5-year actuarial locoregional control rates were 85 +/- 5% and 83 +/- 5%, respectively. Thirty patients (54%) developed laryngeal complications. However, just one patient experienced grade 4 laryngeal oedema requiring permanent tracheostomy. Estimated actuarial survival without laryngeal complications were 50 +/- 7%, 43 +/- 7%, and 39 +/- 7% at 2, 5, and 10 years, respectively. At univariate analysis, treated volumes (P = .03) and total dose to the larynx (P = .03) were significantly associated with local toxicity. A trend was observed also for the maximum dose to the neck (P = .06) and dose per fraction (P = .09). A multivariate Cox proportional hazards model showed total dose to the larynx to be the only independent predictor of toxicity (P = .03). The hazard ratio of laryngeal toxicity was 2.2 (95% confidence interval: 1.1 @?; 4.6), for a total dose to the larynx greater than 50 Gy. Conclusion:: After supraglottic laryngectomy, postoperative RT to the neck does not affect local morbidity, but careful RT treatment planning is necessary to avoid delivering a total dose to the larynx greater than 50 Gy.

Published
2000
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26. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

Author

Gloria Lombardo, Jian Xiong, Yue Hu, Matteo Samuele Pizzuto, Diego Morone, Renato Piantanida, Stefano Jaconi, Ozan S. Kumru, Davide Corti, Lisa Perruzza, Sangeeta B. Joshi, David B. Volkin, Fabio Grassi, Sakshi Bajoria, Debora Pinna, Francesco Strati, Fabio Benigni, Frauke Seehusen, Perruzza, L, Jaconi, S, Lombardo, G, Pinna, D, Strati, F, Morone, D, Seehusen, F, Hu, Y, Bajoria, S, Xiong, J, Kumru, O, Joshi, S, Volkin, D, Piantanida, R, Benigni, F, Grassi, F, Corti, D, Pizzuto, M, University of Zurich, Grassi, Fabio, and Pizzuto, Matteo Samuele

Subjects
0301 basic medicine, Neutrophils, medicine.disease_cause, Immunoglobulin G, Mice, 0302 clinical medicine, Campylobacter Infections, Immunology and Allergy, Intestinal Mucosa, Original Research, Disease Resistance, biology, Campylobacter, Antibodies, Monoclonal, Antibodies, Bacterial, Gastroenteritis, secretory IgA, Monoclonal, Bacterial Vaccines, 2723 Immunology and Allergy, Female, monoclonal antibodies, prophylaxis, Immunotherapy, Antibody, flagellar-capping protein, lcsh:Immunologic diseases. Allergy, medicine.drug_class, Immunology, Campylobacteriosis, 10184 Institute of Veterinary Pathology, Monoclonal antibody, Gastrointestinal epithelium, Microbiology, Enteritis, 03 medical and health sciences, Bacterial Proteins, medicine, Animals, Humans, FliD, monoclonal antibodie, 2403 Immunology, business.industry, prophylaxi, medicine.disease, Immunoglobulin A, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, biology.protein, 570 Life sciences, business, lcsh:RC581-607, 030215 immunology
Abstract

Campylobacter infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. In this study, we describe the prophylactic activity of orally delivered recombinant SIgA generated from two human monoclonal antibodies (CAA1 and CCG4) isolated for their reactivity against the flagellar-capping protein FliD, which is essential for bacteria motility and highly conserved across Campylobacter species associated with severe enteritis. In an immunocompetent weaned mouse model, a single oral administration of FliD-reactive SIgA CAA1 or CCG4 at 2 h before infection significantly enhances Campylobacter clearance at early stages post-infection, reducing the levels of inflammation markers associated with epithelial damage and polymorphonuclear (PMN) cells infiltration in the cecum lamina propria. Our data indicate that the prophylactic activity of CAA1 and CCG4 is not only dependent on the specificity to FliD but also on the use of the SIgA format, as the immunoglobulin G (IgG) versions of the same antibodies did not confer a comparable protective effect. Our work emphasizes the potential of FliD as a target for the development of vaccines and supports the concept that orally administered FliD-reactive SIgA can be developed to prevent or mitigate the severity of Campylobacter infections as well as the development of post-infection syndromes.

Published
2020

27. Oncocytic papillary cystadenoma of the larynx: a case report.

Author

Caranti A, Spasiano R, Piantanida R, Catalano S, Campisi R, Bergmann M, and Trimarchi M

Subjects
Female, Humans, Aged, Salivary Glands pathology, Cystadenoma, Papillary diagnosis, Cystadenoma, Papillary pathology, Dysphonia etiology, Dysphonia pathology, Salivary Gland Neoplasms diagnosis, Larynx pathology
Abstract

Background: Cystadenoma of the salivary glands is a rare benign clinical condition affecting both major and minor salivary glands equally. It constitutes approximately 2% of total neoplasms and 4.2-4.7% of benign formations in minor salivary glands. Typically presenting as a slow-growing, painless neoplasm, it can be distinguished from Cystadenolymphoma (Whartin's Tumor) by the absence of lymphoid elements in histological examination. While mostly located in the oral cavity and oropharynx, it can also be found in sinonasal mucosa, and rare cases have been identified in the larynx., Case Presentation: A 75-year-old Caucasian woman presented to the ear, nose, and throat department with complaints of dysphonia and headaches persisting for several months. Dysphonia had developed months after an unspecified vocal cord surgery elsewhere. Flexible laryngoscopy identified a left-sided cystic swelling affecting the supraglottic space, leading to respiratory obstruction and dysphonia. Head and neck computed tomography confirmed a 1.9 × 1.7 cm bilobed cystic mass originating from the left Morgagni ventricle. Microlaryngoscopy with CO 2 laser excision and biopsy revealed a histopathological diagnosis of oncocytic papillary cystadenoma. Post-surgery, the patient fully recovered from dysphonia, with no significant complications noted. Long-term clinical surveillance was advised to detect potential recurrences promptly., Conclusion: Ectopic minor salivary gland tumors, both benign and malignant, should be taken into consideration as potential differential diagnosis for any swelling arising within the upper digestive tract mucosa. Ears, nose, and throat clinical examination completed by videolaryngoscopy can easily point out the location of the mass. Imaging is mandatory for differential diagnosis and for surgical planning. Surgical excision can provide both diagnosis and definitive cure., (© 2024. The Author(s).)

Published
2024
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28. Gantry-needle-target alignment technique for CT-guided needle approaches to the skull base and cranio-cervical junction.

Author

Pileggi M, Ventura E, Di Napoli A, Piantanida R, Muto M, Cardia A, and Cianfoni A

Subjects
Head, Humans, Retrospective Studies, Skull Base, Cervical Vertebrae diagnostic imaging, Tomography, X-Ray Computed methods
Abstract

Purpose: CT-guided percutaneous procedures involving the skull base and atlanto-axial cervical spine pose particular challenges due to high density of vital vascular and nervous structures and because the ideal needle trajectory often has a cranio-caudal obliquity different from the axial scan plane. We describe how the variable CT gantry tilt, combined with gantry-needle-target alignment technique, is used to obtain precise and safe needle placement in conventional and non-conventional approaches to the skull base and the atlanto-axial spine., Methods: We retrospectively analyzed consecutive CT-guided needle accesses to the skull base and atlanto-axial spine performed for tissue sampling through fine-needle aspirates and core biopsies, cementoplasty of neoplastic lytic lesions of atlanto-axial spine, pain management injections, and dural puncture for cerebro-spinal fluid sampling. All the accesses were performed with the gantry-needle-target alignment technique. Procedural complications were recorded., Results: Thirty-nine CT-guided procedures were analyzed. Paramaxillary approach was used in 15 cases, postero-lateral in 11, subzygomatic in 3. Nine non-conventional approach were performed: submastoid in 3 cases, suprazygomatic in 2, trans-nasal in 2, trans-mastoid in 1, and trans-auricular in 1. Two peri-procedural complications occurred: one asymptomatic and one resolved within 24 h. All the procedures were successfully completed with successful needle access to the target., Conclusion: The gantry tilt and gantry-needle-target alignment technique allows to obtain double-oblique needle accesses for CT-guided procedures involving the skull base and atlanto-axial cervical spine, minimizing uncertainty of needle trajectory and obtaining safe needle placement in conventional and non-conventional approaches., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2022
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29. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection.

Author

Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru OS, Joshi SB, Volkin DB, Piantanida R, Benigni F, Grassi F, Corti D, and Pizzuto MS

Subjects
Animals, Antibodies, Bacterial metabolism, Antibodies, Monoclonal metabolism, Disease Models, Animal, Disease Resistance, Female, Humans, Immunoglobulin A metabolism, Mice, Mice, Inbred C57BL, Bacterial Proteins immunology, Bacterial Vaccines immunology, Campylobacter physiology, Campylobacter Infections immunology, Gastroenteritis immunology, Immunotherapy methods, Intestinal Mucosa immunology, Neutrophils immunology
Abstract

Campylobacter infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. In this study, we describe the prophylactic activity of orally delivered recombinant SIgA generated from two human monoclonal antibodies (CAA1 and CCG4) isolated for their reactivity against the flagellar-capping protein FliD, which is essential for bacteria motility and highly conserved across Campylobacter species associated with severe enteritis. In an immunocompetent weaned mouse model, a single oral administration of FliD-reactive SIgA CAA1 or CCG4 at 2 h before infection significantly enhances Campylobacter clearance at early stages post-infection, reducing the levels of inflammation markers associated with epithelial damage and polymorphonuclear (PMN) cells infiltration in the cecum lamina propria. Our data indicate that the prophylactic activity of CAA1 and CCG4 is not only dependent on the specificity to FliD but also on the use of the SIgA format, as the immunoglobulin G (IgG) versions of the same antibodies did not confer a comparable protective effect. Our work emphasizes the potential of FliD as a target for the development of vaccines and supports the concept that orally administered FliD-reactive SIgA can be developed to prevent or mitigate the severity of Campylobacter infections as well as the development of post-infection syndromes., (Copyright © 2020 Perruzza, Jaconi, Lombardo, Pinna, Strati, Morone, Seehusen, Hu, Bajoria, Xiong, Kumru, Joshi, Volkin, Piantanida, Benigni, Grassi, Corti and Pizzuto.)

Published
2020
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30. 18 F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging.

Author

Paone G, Martucci F, Espeli V, Ceriani L, Treglia G, Ruberto T, Richetti A, Piantanida R, and Giovanella L

Subjects
Aged, Aged, 80 and over, Clinical Decision-Making, Double-Blind Method, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Laryngeal Cartilages diagnostic imaging, Laryngeal Cartilages pathology, Laryngeal Neoplasms pathology, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Invasiveness diagnostic imaging, Progression-Free Survival, ROC Curve, Retrospective Studies, Sensitivity and Specificity, Tomography, X-Ray Computed, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Glottis diagnostic imaging, Laryngeal Neoplasms diagnostic imaging, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals
Abstract

This study assessed the role of 18 F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or magnetic resonance). In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in terms of event-free survival (EFS) and overall survival (OS). We retrospectively analyzed 27 patients with glottic squamous cell carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and radiotherapy planning, and CI findings. Cohen's K was used to compare concordance between PET/CT and CI. Imaging findings were correlated with endoscopic evaluation and histological reports (gold standard (GS)). All lesions shown by CI were also detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT). Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively. MRI showed sensitivity and specificity of 100%. One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/CT with no difference compared to MRI (10 cases). Six FN cases and 1 FP case were observed with CT. Cohen's K was 0.60 (PET vs. CI) and 0.80 (PET vs. GS). Patients were followed-up for at least 24 months to calculate EFS and OS. 13 local recurrence and 7 deaths were recorded. Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome. Our data suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local staging in addition to the well-established role in lymph-node and distant sites assessment. Furthermore, pretreatment MTV provides better prognostic information than other PET/CT parameters., Competing Interests: The authors declare no conflicts of interest.

Published
2019
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31. Elective treatment of the neck in squamous cell carcinoma of the larynx: clinical experience.

Author

Spriano G, Piantanida R, Pellini R, and Muscatello L

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Female, Humans, Laryngeal Neoplasms mortality, Laryngeal Neoplasms pathology, Lymphatic Metastasis, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies, Survival Analysis, Treatment Outcome, Carcinoma, Squamous Cell surgery, Elective Surgical Procedures, Laryngeal Neoplasms surgery, Neck Dissection methods
Abstract

Background: In head and neck cancer, the best prophylactic treatment for the N0 neck is a subject of debate. Some authors propose lateral selective lymph node dissection (levels II-IV) on the basis of the probability of finding occult metastases in those lymph nodes. A more extensive procedure including Vth level is considered unnecessary because of the low incidence of metastases in the posterior triangle., Methods: We retrospectively evaluated 346 N0 patients affected by laryngeal carcinoma and consecutively treated at the Department of Otorhinolaryngology of the Ospedale di Circolo, Varese, Italy. The patients underwent elective selective neck dissection (levels II-V) for a total of 602 dissected heminecks., Result: Seventy heminecks (11.6%) were pN+, and in 10 of 70 cases (14.3%) level V was involved; in 5 of 10 metastases were isolated., Conclusion: Our retrospective study confirms the probabilistic criteria of the incidence of occult metastasis by level in laryngeal cancer. On the basis of our data Vth level nodes, although very rarely, 10 of 604 (1.6%), are involved with laryngeal cancer. Our approach to routinely dissect Vth level nodes is discussed., (Copyright 2003 Wiley Periodicals, Inc.)

Published
2003
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32. [Castleman disease with lateral neck outset. Report of a clinical case].

Author

Casati E, Di Iorio D, Tricomi P, Pezzotta MG, and Piantanida R

Subjects
Adult, Female, Humans, Neck, Castleman Disease diagnosis
Abstract

This work presents the case of a young woman with Castleman's disease, manifest as an isolated, asymptomatic swelling in the supraclavear fossae. A fine needle biopsy was performed on the swelling and cytology on this material proved insignificant (blood cells), while CT and MRI did not show any significant vascular components nor did they provide any elements decisive for diagnosis, the neoformation being similar to a reactive lymph node. To determine the nature of the mass, the lesion was removed by cervicotomy. Histology then led to a definitive diagnosis of a hyaline vascular variant of Castleman's disease. The literature on the topic was then reviewed with an eye to otorhinolaryngological manifestations and the histological aspects and clinical-diagnostic approach are discussed in detail.

Published
2001

33. [Palatine tonsillar metastasis from small cell carcinoma of the lung].

Author

Bozza F, Piantanida R, Pellini R, and Spriano G

Subjects
Aged, Carcinoma, Small Cell therapy, Combined Modality Therapy, Female, Humans, Lung Neoplasms therapy, Tonsillar Neoplasms therapy, Carcinoma, Small Cell secondary, Lung Neoplasms pathology, Palatine Tonsil, Tonsillar Neoplasms secondary
Abstract

With regard to the rarity of metastatic tumor of the oropharyngeal region, we report a case of tonsillar metastases from the small cell carcinoma of the lung with controlateral cervical lymphadenopathy. The review of literature and the our clinic experience confirms the opportunity for an exclusively palliative treatment as then one no survivors in such events.

Published
2000

34. [Radiation treatment of early stage supraglottic cancer].

Author

Spriano G, Ferrario F, Roselli R, Piantanida R, and Antognoni P

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell diagnosis, Disease-Free Survival, Dose-Response Relationship, Radiation, Female, Humans, Hypopharyngeal Neoplasms diagnosis, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Radiotherapy adverse effects, Retrospective Studies, Carcinoma, Squamous Cell radiotherapy, Hypopharyngeal Neoplasms radiotherapy
Abstract

The management of early-stage squamous cell carcinoma (SCC) of the supraglottic larynx is still controversial. Supraglottic laryngectomy as well as irradiation alone is correlated with good oncological and functional results. In order to evaluate the results and prognostic factors influencing the successful using radiotherapy (RT), the authors performed a retrospective study of 100 consecutive T1-T2 N0 M0 cases of SCC of the supraglottic larynx, treated at a single institution between 1983 and 1992. RT was delivered with 60Co or 6 MeV photons through two lateral parallel opposed portals encompassing the primary laryngeal tumor and the upper and mid-neck nodes (Robbins' levels II, III and V). Supraclavicular nodes (level IV) were electively irradiated in 54 patients with T2 N0 tumors only, using an anterior field with midline block. Sixty-three patients received conventional fractionation (2 Gy/fraction, once-a-day, five times a week), while 37 patients were irradiated according to a twice-a-day fractionation regimen (1.5 Gy/fraction, twice a day with six-hour interval, five days a week). The median total tumor dose delivered was 67 Gy. A multivariate analysis showed that performance status, tumor grade and fractionation modality were the only statistically significant variables influencing disease-free survival. Acute and late radiation reactions were relatively low. This retrospective study confirms that conservative management of T1-T2 N0 supraglottic cancer using RT can achieve good cure rates with the possibility of larynx preservation for the majority of the patients. The decision between different conservative treatment modalities may be influenced by several factors correlated to the patient's conditions, tumor characteristics, but especially treatment modalities.

Published
1999

35. Reconstruction of major orbital-maxillary defects with free latissimus dorsi myocutaneous flap.

Author

Piantanida R, Roselli R, Pellini R, Ferrario F, Boschini P, and Spriano G

Subjects
Carcinoma, Basal Cell surgery, Carcinoma, Squamous Cell surgery, Head and Neck Neoplasms rehabilitation, Humans, Muscle, Skeletal transplantation, Skin Transplantation, Head and Neck Neoplasms surgery, Maxilla surgery, Orbit surgery, Surgical Flaps
Abstract

Reconstruction following excision of tumors of the orbital-maxillary region represents a challenge to the head and neck surgeons. Microvascular techniques have significantly improved the possibilities of an adequate three-dimensional repair. Among the different available options, the latissimus dorsi myocutaneous flap (LDMF) has been considered, as it seems to fulfill the requirements for a functional obliterations of the orbital-maxillary cavity and to restore the facial contour. Two cases of large orbital-maxillary defects repaired with a LDMF are reported; in one of them the intraoral palatal competence and lining were achieved through a temporalis muscle flap. Technical remarks are presented and discussed as well as the indications and possibilities for more sophisticated reconstructions, aimed at a better cosmetic outcome.

Published
1999
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36. [Basaloid-squamous cell carcinoma of the larynx: a new morphologic entity. Case report].

Author

Ferrario F, Spriano G, Macchi A, Piantanida R, and Della Vecchia L

Subjects
Aged, Carcinoma, Basosquamous therapy, Combined Modality Therapy, Fatal Outcome, Humans, Laryngeal Neoplasms therapy, Male, Tomography, X-Ray Computed, Carcinoma, Basosquamous diagnostic imaging, Carcinoma, Basosquamous pathology, Laryngeal Neoplasms diagnostic imaging, Laryngeal Neoplasms pathology
Abstract

Basaloid-Squamous Cell Carcinoma (BSCC) is considered a biologically aggressive variation of squamous cell carcinoma (SCC). Wain et al. first reported BSCC as an independent neoplasm in 1986. In the past, it was most likely misinterpreted as atypical SCC. To date approximately one hundred cases have been reported in the literature. The pathognomonic characteristic of BSCC is an intimate association between basaloid and squamous patterns: for this reason a small biopsy specimen may be insufficient for correct diagnosis. In such cases, knowledge of the biological behavior of these tumors (i.e. local aggressiveness and tendency to spread both regionally and at a distance) may prove useful. Prognosis and survival rates are certainly worse than in SCC. Within the upper aero-digestive tract, BSCC is most likely to arise in the supraglottic larynx, the pyriform sinus and the base of the tongue. Treatment should include surgery of the primary tumor and of the neck lymph nodes, followed by radiotherapy. The authors present a new case report indicating the typical feature of this tumor (aggressiveness, synchronous basaloid and squamous histology, supraglottic involvement.

Published
1998

37. [Surgical treatment of otosclerosis in the aged. Results of retrospective analysis].

Author

Ferrario F, Spriano G, Piantanida R, Macchi A, and Boschini P

Subjects
Age Factors, Aged, 80 and over, Audiometry, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Stapes Surgery, Time Factors, Aged, Otosclerosis surgery
Abstract

Otosclerosis is, per se, a disease which rarely occurs after the age of 50. This is why stapes surgery is seldom performed in advanced age and there are few reports on the topic in the literature. The authors have performed a retrospective analysis of patients over the age of 65 who had undergone surgery for otosclerosis in the last 27 years. Out of a total of 3585 surgical procedures, 106 patients were analyzed. Most of the cases were in the advanced stages. Assessment of the outcome included pre- and post-operative audiometry, one year after surgery. Inner ear performance was established by evaluating air and bone conduction at 0.5, 1, 2, 3 and 4 kHz. The results showed that performing otosclerosis surgery is worthwhile even in the elderly with mixed auditory impairment, as long as the air-bone gap is limited to 20-30 dB and the surgical procedure is through. In this light, stapedotomy appears to be the most adequate technique. When evaluating the results the possibility of adopting a less powerful hearing aid should also be considered a success.

Published
1997

38. Conservative management of T1-T2N0 supraglottic cancer: a retrospective study.

Author

Spriano G, Antognoni P, Piantanida R, Varinelli D, Luraghi R, Cerizza L, and Tordiglione M

Subjects
Adult, Aged, Carcinoma, Squamous Cell mortality, Female, Humans, Laryngeal Neoplasms mortality, Laryngectomy, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Prognosis, Radiation Dosage, Retrospective Studies, Survival Rate, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Glottis radiation effects, Glottis surgery, Laryngeal Neoplasms radiotherapy, Laryngeal Neoplasms surgery
Abstract

Purpose: Evaluate the results of conservative management of early-stage supraglottic cancer., Patients and Methods: A retrospective analysis of 166 consecutive T1-T2N0 cases of squamous cell carcinoma of the supraglottic larynx, treated conservatively between 1983 and 1992, was performed. Sixty-six patients received conservative surgery (CS), whereas 100 patients received definitive radiation therapy (RT). Surgical procedures included horizontal supraglottic laryngectomy in 38 patients, extended supraglottic laryngectomy in 16 patients, and reconstructive laryngectomy with cricohyoidopexy in 12 patients. Elective bilateral neck dissection was always performed. Radiotherapy was delivered with 60Co or 6 MV photons to the primary laryngeal tumor and the upper and mid neck nodes (level II and III), whereas supraclavicular nodes (level IV) were electively irradiated only in 54 patients with T2N0 tumors. Fifty-two patients received conventional fractionation, whereas 31 patients were irradiated according to a twice-a-day fractionation regimen. The median total tumor dose was 67 Gy (range, 64 to 72 Gy)., Results: The 5-year overall survival of the whole series was 72.7% +/- 4.5. In patients treated with CS, the 5-year disease-free survival was 88.4% +/- 4.5 versus 76.4% +/- 6.1 for patients who received RT. Salvage surgery was effective in rescuing 2 of 3 CS failures and 12 of 25 RT failures. The overall incidence of secondary tumors (11%) and distant metastases (5%) was relatively low, although together they account for 15% of all deaths. Complications of CS were significantly correlated to the extent of surgical procedure. A multivariate analysis performed in the RT group showed that performance status, tumor grade, and fractionation regimen significantly influenced disease-free survival., Conclusion: Conservative management of T1-T2N0 supraglottic cancer, either by CS or RT, can achieve good cure rates with larynx preservation for the majority of the patients (82% overall; 95% in the CS group and 72% in the RT group). The decision between different conservative treatment modalities may be influenced by the patient's conditions, tumor characteristics, treatment modalities, and also economic costs.

Published
1997
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39. [A free radial forearm flap in oral cavity reconstruction].

Author

Piantanida R, Ferrario F, Roselli R, and Spriano G

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Forearm surgery, Mouth surgery, Oropharyngeal Neoplasms surgery, Surgical Flaps
Abstract

A relatively recent method for reconstruction of the oral cavity after tumor removal employs the use of revascularized free flaps. In particular, the Radial Forearm Flap has gained significant international recognition. After a review of the history of this procedure, the authors describe the essential aspects of the technique including what is involved in removal as well as in microanastomosis and reconstruction. In addition, the paper also deals with operative patient monitoring, prevention and treatment of any complications. Finally, a series of 10 cases is presented all of which underwent surgery at the E.N.T. Division of the Varese Hospital. The case study presents the oncological and functional results and emphasizes the technical details of the entire sampling. The purpose of this work has been to demonstrate that this procedure can be used by an E.N.T. surgical staff without requiring input from an outside team of specialists. Although this technique is difficult and somewhat limited, it must be considered one of the most innovative proposals in the field of plastic, reconstructive surgery of the head and neck.

Published
1997

40. [Idiopathic thrombosis of the internal jugular vein].

Author

Ferrario F, Spriano G, Belli L, Roselli R, and Piantanida R

Subjects
Anticoagulants therapeutic use, Female, Humans, Magnetic Resonance Angiography, Middle Aged, Tomography, X-Ray Computed, Jugular Veins, Thrombosis diagnosis, Thrombosis etiology, Thrombosis therapy
Abstract

The venous thrombosis represents a vascular disorder usually involving the low limbs. The manifestation at the level of the upper limbs and the neck is much more rare, particularly as a consequence of a central venous catheterization of an infectious disease or of a trauma. The authors report an unusual case of spontaneous thrombosis of the internal jugular vein and analyze the most salient nosologic, diagnostic and therapeutic aspects.

Published
1997

41. [Solitary fibrous tumor of the nasopharynx. Apropos of a case].

Author

Ferrario F, Piantanida R, Spriano G, Cerati M, Maffioli M, and Roselli R

Subjects
Adult, Humans, Magnetic Resonance Imaging, Male, Mesothelioma diagnosis, Nasopharyngeal Neoplasms diagnosis, Mesothelioma pathology, Nasopharyngeal Neoplasms pathology
Abstract

Solitary fibrous tumor (SFT) is a rare neoplasm, arising in the adult and more commonly in the pleura. For many years it has been referred to the serous surfaces of the body, namely pleura, peritoneum and pericardium; recently cases arising in mesenchymal organs such as lung, mediastinum, liver and paranasal sinuses were reported. We present a SFT of the nasopharynx, observed in a 41 year-old patient complaining a 6 months history of aural fullness at the right ear. Clinical examination revealed the presence of secretory otitis media and swelling of the lateral wall of the nasopharynx. CT scan and MR showed the presence of a solid mass, with scarce vascularization, extending from the right side of the nasopharynx to the infratemporal and pterigoid fossae. The surgical approach consisted in a facial translocation by the rotation of a maxillary-check flap through different osteotomies; a firm whitish mass not invading the surrounding tissues was identified and enucleated. A definitive diagnosis cannot be made at frozen sections, requiring more accurate processing and immunohistochemical staining. Literature reports fourteen cases of SFT of the upper aero-digestive tracts (nasopharynx, paranasal sinuses, larynx) and some 8 more cases in the head and neck area (thyroid, salivary glands and parapharyngeal spaces). This case report adds a further contribution to support the mesenchymal origin of the SFT.

Published
1997

42. [Cutaneous head and neck carcinomas: biological characteristics, natural history and clinical classification].

Author

Piantanida R, Maffioli M, and Marchesi A

Subjects
Carcinoma, Squamous Cell diagnosis, Head and Neck Neoplasms diagnosis, Humans, Skin Neoplasms diagnosis, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Skin Neoplasms pathology
Abstract

In cutaneous carcinoma of the Head and Neck there is a 7% of cases that often suffer substantial morbidity and even mortality. The identification of the "high-risk patient" may derive from the study of the prognostic factors which have been published in Literature. The problem has to be differentiated between the basal cells carcinoma (BCC) and the squamous cells carcinoma (SCC) due to the locally limited aggressiveness of the first and the potential for metastatization of the latter. The evaluation of the different variables confirms the inadequacy of the present TNM Classification for Cutaneous carcinoma; nevertheless the opportunity of a new and omni-comprehensive proposal is questionable.

Published
1995

43. [Primary lymphoma of the sphenoid sinus. Report of a case and review of the literature].

Author

Ferrario F, Roselli R, Piantanida R, Boschini P, and Maffioli M

Subjects
Aged, Combined Modality Therapy, Diagnosis, Differential, Humans, Lymphoma, Non-Hodgkin therapy, Magnetic Resonance Imaging, Male, Paranasal Sinus Neoplasms therapy, Prognosis, Tomography, X-Ray Computed, Lymphoma, Non-Hodgkin diagnosis, Paranasal Sinus Neoplasms diagnosis, Sphenoid Sinus
Abstract

The Authors describe a case of primary isolated non-Hodgkin lymphoma with sphenoidal presentation. According to literature, this is the third specification quoted in the whole world. The diagnostic approach for this clinical entity is emphasized, stressing the importance of the complete radiological and endoscopic work-up.

Published
1995

44. [Prospective, cohort, epidemiologic studies of laryngeal neoplasms in Italy].

Author

Ferrario F, Maffioli M, Piantanida R, Boschini P, and Spriano G

Subjects
Adult, Age Factors, Aged, Cohort Studies, Female, Humans, Italy epidemiology, Male, Middle Aged, Prospective Studies, Sex Factors, Laryngeal Neoplasms epidemiology, Lung Neoplasms epidemiology
Abstract

Recent epidemiological studies show, quite surprisingly, a regression in mortality rates for lung cancer in some of the most industrialized countries of the world. Aetiopathogenetic analogies are made by the Authors in order to verify future trends concerning the incidence of laryngeal cancer in Italy. In this study a particular study model, which furnishes incidence rate expectations for the disease, is elaborated. Comparison of relative risks according to birth dates demonstrates that people born around 1930 are in the higher risk range while younger generations seem to show an effective incidence reduction. Evaluations include that of estimating the period in which the world-wide incidence of the disease will be maximum. With the addition of 70 years (main incidence in the seventh decade) to the year 1930 (the worst year) the study predicts that the end of this century will see the most consistent accumulation of new cases. After the year 2010 a trend towards a gradual regression in incidence will appear. The reasons are probably related to the social and cultural transformations of the last twenty years, particularly the progressive abandoning of the smoking habit.

Published
1992

45. [Intestinal type adenocarcinoma of the nose and paranasal sinuses. Histological and immunohistochemical study of 14 cases].

Author

Bonato M, Piantanida R, Riva C, Cis C, and Capella C

Subjects
Adenocarcinoma genetics, Adenocarcinoma immunology, Adult, Aged, Biomarkers, Tumor, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasms classification, Nose Neoplasms genetics, Nose Neoplasms immunology, Paranasal Sinus Neoplasms genetics, Paranasal Sinus Neoplasms immunology, Adenocarcinoma pathology, Nose Neoplasms pathology, Paranasal Sinus Neoplasms pathology
Abstract

Fourteen cases of intestinal-type adenocarcinomas (IADC) of the nasal cavity and paranasal sinuses were studied at the Regional Hospital of Varese during the period from 1973 to 1988. They were 13 males and 1 female, mean age 57.5 years; the five year survival was 25% and tumors were preferentially located in the ethmoidal sinus. Morphological study and the use of monoclonal and polyclonal antibodies made it possible to define the structural features of IADC and to detect specific antigenic markers such as CAR-5 (a glycoprotein contained within intestinal goblet-cells) and M1 (a glycoprotein contained within gastric foveolar cells). For comparison 10 cases of colonic adenocarcinomas and 14 cases of non-AIDC carcinomas of the nose and paranasal sinuses were also examined. The parallel morphological and immuno-histochemical investigations based on specific markers demonstrated that it was impossible to differentiate IADC from large bowel adenocarcinoma for both the structural pattern and antigenic expression. Moreover, AIDC also showed a CAR-5 and M1 immunoreactivity (IR) different from that displayed by the nasal carcinomas of different histotypes. From a histopathological standpoint IADC appears to be a distinctive entity even when compared to salivary gland tumors. In addition, the present immunohistochemical investigation demonstrates that gastric and intestinal glycoproteic antigens (M1 and CAR-5 respectively) occur in the normal nasosinusal mucosa. Both CAR-5 and M1 were observed in the mucous produced by nasal goblet cells with a distribution pattern resembling that of colonic goblet cells. Therefore, the present data confirm the similarity between nasal and colonic goblet cells which has already been pinpointed in previous morphological and ultrastructural studies. The common antigenic expression shared by the naso-sinusal and colonic mucosa might suggest a histogenetic hypothesis alternative to those of the malformative or metaplastic origin of naso-sinusal IADC.

Published
1989

46. [Salvage surgery after unsuccessful radiotherapy of cancer of the larynx].

Author

Spriano G, Piantanida R, and Maffioli M

Subjects
Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Humans, Laryngeal Neoplasms pathology, Laryngeal Neoplasms radiotherapy, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Laryngeal Neoplasms surgery, Neoplasm Recurrence, Local surgery
Abstract

The problem of the surgical management of irradiation failures in laryngeal carcinoma is taken into consideration. A series of 60 consecutive laryngectomies performed at the E.N.T. Department of the Regional Hospital of Varese from 1982-1987 is presented. All patients had previously undergone curative radiotherapy for squamous cell carcinoma of the larynx with subsequent local recurrence. The postoperative course is examined in relation to the observed 11 cases of complications (18.3%) taking them into consideration individually. A statistical analysis is also presented for the incidence of complications in relation to the most significant parameters. No significant difference was found in regard to timer elapsed since termination of radiotherapy (more or less than 6 months), irradiation field extension (limited to the larynx or extended to the neck nodes), type of surgical salvage (including neck dissection or not) and pre-operative hemoglobin and blood proteins values. In those patients who had previously undergone irradiation, total laryngectomy is quite a safe procedure in terms of potential local-regional complications. The choice of primary radiotherapy should not be influenced by the fear of such complications arising if salvage surgery is required after local recurrence.

Published
1989

47. [Treatment of carcinoma of the tongue: results of a retrospective study].

Author

Spriano G, Bertoni F, Boschini P, Piantanida R, and Premoli A

Subjects
Aged, Brachytherapy, Carcinoma radiotherapy, Carcinoma surgery, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Radiotherapy Dosage, Retrospective Studies, Time Factors, Tongue Neoplasms radiotherapy, Tongue Neoplasms surgery, Carcinoma therapy, Tongue Neoplasms therapy
Published
1986

48. [Surgery of the parathyroid glands in chronic renal insufficiency].

Author

Spriano G, Donati D, Roberto V, Boschini P, Piantanida R, and Premoli A

Subjects
Adult, Aged, Female, Hand diagnostic imaging, Humans, Hyperparathyroidism, Secondary diagnostic imaging, Male, Middle Aged, Radiography, Hyperparathyroidism, Secondary surgery, Kidney Failure, Chronic complications, Parathyroid Glands surgery
Published
1985

49. [Radical radiotherapy in carcinoma of the hypopharynx].

Author

Bertoni F, Stucchi F, Terraneo F, Scandolaro L, Cazzaniga F, Premoli A, and Piantanida R

Subjects
Aged, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Female, Humans, Hypopharyngeal Neoplasms mortality, Hypopharyngeal Neoplasms pathology, Male, Middle Aged, Prognosis, Radiotherapy Dosage, Carcinoma, Squamous Cell radiotherapy, Hypopharyngeal Neoplasms radiotherapy, Pharyngeal Neoplasms radiotherapy
Published
1985

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