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13 results on '"Piao, Honglan"'

7. Neuropeptide Y selectively potentiates alpha1-adrenoceptor-mediated contraction through Y1 receptor subtype in rat femoral artery

Author

Tatsuru Tsurumaki, Piao Honglan, and Hiroshi Higuchi

Subjects
Male, medicine.medical_specialty, Serotonin, Contraction (grammar), medicine.drug_class, Neuropeptide, Gene Expression, Aorta, Thoracic, Femoral artery, Arginine, Muscle, Smooth, Vascular, Phenylephrine, medicine.artery, Internal medicine, Receptors, Adrenergic, alpha-1, medicine, Animals, Humans, Neuropeptide Y, Rats, Wistar, Receptor, Pharmacology, Dose-Response Relationship, Drug, Chemistry, Reverse Transcriptase Polymerase Chain Reaction, Long-term potentiation, Drug Synergism, Receptor antagonist, Neuropeptide Y receptor, Rats, Receptors, Neuropeptide Y, Femoral Artery, Endocrinology, Cardiology and Cardiovascular Medicine, medicine.drug, Muscle Contraction
Abstract

The aim of this study was to investigate the synergism between neuropeptide Y and other vasoconstrictors (phenylephrine and serotonin) and which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation. Exogenous neuropeptide Y (10 nM) potentiated a 1 -adrenoceptor-mediated (PE-induced) contraction in rat femoral artery permissively without its direct action, but not in the thoracic aorta. In contrast, neuropeptide Y produced no change in serotonin-induced contraction in both arteries. Increasing concentrations of neuropeptide Y caused dose-dependent potentiation of the phenylephrine-induced contraction in the femoral artery. This potentiation was blocked by a selective neuropeptide Y-Y 1 receptor antagonist, BIBP3226 [(R)-N 2 -(diphenylacetyl)-N-[4-hydroxyphenyl)methyl]-argininamide] (1 μM). Semiquantitative reverse transcriptase polymerase chain reaction showed the selective expression of neuropeptide Y-Y 1 receptor mRNA in the femoral artery. These findings indicated that the neuropeptide Y-induced selective potentiation of α 1 -adrenoceptor-mediated contraction is mediated through neuropeptide Y-Y 1 receptor in rat femoral artery.

Published
2004

8. Renal Inflammatory Changes in Acute Hepatic Failure-Associated Acute Kidney Injury

Author

Shimizu, Akira, primary, Ishii, Eiichi, additional, Masuda, Yukinari, additional, Sato, Ayako, additional, Piao, Honglan, additional, Kunugi, Shinobu, additional, Takahashi, Mikiko, additional, Terasaki, Mika, additional, Nagasaka, Shinya, additional, Terasaki, Yasuhiro, additional, Ohashi, Ryuji, additional, Morioka, Testuo, additional, and Fukuda, Yuh, additional

Published
2013
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13. Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels

Author

Piao, Honglan, Nagai, Shingo, Tsurumaki, Tatsuru, Niki, Takeshi, and Higuchi, Hiroshi

Subjects
*HISTAMINE, *NEUROPEPTIDE Y, *LABORATORY rats, *VASOCONSTRICTION, *CHEMICAL inhibitors, *MESSENGER RNA, *POLYMERASE chain reaction, *PHOSPHOLIPASE C
Abstract

Abstract: Histamine-induced contraction and its potentiation by neuropeptide Y were investigated in rat blood vessels. Rat arteries and veins constricted with single concentrations of histamine dose-dependently (0.1–100 μM). This histamine-induced contraction immediately desensitized. Histamine H1 receptor antagonists, 1 μM mepyramine and 1 μM diphenhydramine, abolished this transient contraction completely, whereas cimethidine, phentolamine, reserpine and tetrodotoxin failed to inhibit the contraction. Histamine H1 receptor mRNA level by reverse transcription-polymerase chain reaction was quite parallel to histamine H1 receptor-mediated contraction, indicating that the contraction is mediated through histamine H1 receptors in the smooth muscle. Neuropeptide Y (10 nM in arteries and 3 nM in veins, respectively) significantly potentiated histamine H1 receptor-mediated contraction via neuropeptide Y1 receptors in most of rat blood vessels. Since the phospholipase C inhibitors, neomycin (1 mM) and 2-nitro-4-carboxyphenyl-N, N-diphenylcarbamate (NCDC, 10 μM), respectively, specifically abolished the potentiation, the potentiation by neuropeptide Y may depend on activation of phospholipase C. [Copyright &y& Elsevier]

Published
2007
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