Search

Your search keyword '"Piazuelo, M. Blanca"' showing total 691 results
Start Over Author "Piazuelo, M. Blanca"
691 results on '"Piazuelo, M. Blanca"'

1. Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production

Author

McNamara, Kara M., Sierra, Johanna C., Latour, Yvonne L., Hawkins, Caroline V., Asim, Mohammad, Williams, Kamery J., Barry, Daniel P., Allaman, Margaret M., Zagol-Ikapitte, Irene, Luis, Paula B., Schneider, Claus, Delgado, Alberto G., Piazuelo, M. Blanca, Tyree, Regina N., Carson, Kate S., Choksi, Yash A., Coburn, Lori A., Gobert, Alain P., and Wilson, Keith T.

Published
2024
Full Text
View/download PDF

5. Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis

Author

Noto, Jennifer M, Piazuelo, M Blanca, Shah, Shailja C, Romero-Gallo, Judith, Hart, Jessica L, Di, Chao, Carmichael, James D, Delgado, Alberto G, Halvorson, Alese E, Greevy, Robert A, Wroblewski, Lydia E, Sharma, Ayushi, Newton, Annabelle B, Allaman, Margaret M, Wilson, Keith T, Washington, M Kay, Calcutt, M Wade, Schey, Kevin L, Cummings, Bethany P, Flynn, Charles R, Zackular, Joseph P, and Peek, Richard M

Subjects
Cancer, Rare Diseases, Digestive Diseases - (Peptic Ulcer), Nutrition, Digestive Diseases, Infectious Diseases, Emerging Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, 2.2 Factors relating to the physical environment, Oral and gastrointestinal, Animals, Antigens, Bacterial, Bacterial Proteins, Bile Acids and Salts, Carcinogenesis, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Humans, Inflammation, Iron Deficiencies, Mice, Stomach Neoplasms, Bacterial infections, Gastric cancer, Gastroenterology, Infectious disease, Mouse models, Medical and Health Sciences, Immunology
Abstract

Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host, and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in INS-GAS mice under iron-deficient conditions. Mechanistically, these phenotypes were not driven by alterations in the gastric microbiota; however, discovery-based and targeted metabolomics revealed that bile acids were significantly altered in H. pylori-infected mice with iron deficiency, with significant upregulation of deoxycholic acid (DCA), a carcinogenic bile acid. The severity of gastric injury was further augmented when H. pylori-infected mice were treated with DCA, and, in vitro, DCA increased translocation of the H. pylori oncoprotein CagA into host cells. Conversely, bile acid sequestration attenuated H. pylori-induced injury under conditions of iron deficiency. To translate these findings to human populations, we evaluated the association between bile acid sequestrant use and gastric cancer risk in a large human cohort. Among 416,885 individuals, a significant dose-dependent reduction in risk was associated with cumulative bile acid sequestrant use. Further, expression of the bile acid receptor transmembrane G protein-coupled bile acid receptor 5 (TGR5) paralleled the severity of carcinogenic lesions in humans. These data demonstrate that increased H. pylori-induced injury within the context of iron deficiency is tightly linked to altered bile acid metabolism, which may promote gastric carcinogenesis.

Published
2022

7. Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification

Author

Gobert, Alain P., Smith, Thaddeus M., Latour, Yvonne L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Williams, Kamery J., McNamara, Kara M., Delgado, Alberto G., Short, Sarah P., Mirmira, Raghavendra G., Rose, Kristie L., Schey, Kevin L., Zagol-Ikapitte, Irene, Coleman, Jeremy S., Boutaud, Olivier, Zhao, Shilin, Piazuelo, M. Blanca, Washington, M. Kay, Coburn, Lori A., and Wilson, Keith T.

Published
2023
Full Text
View/download PDF

9. Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Author

Gobert, Alain P., Latour, Yvonne L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Finley, Jordan L., Smith, Thaddeus M., McNamara, Kara M., Singh, Kshipra, Sierra, Johanna C., Delgado, Alberto G., Luis, Paula B., Schneider, Claus, Washington, M. Kay, Piazuelo, M. Blanca, Zhao, Shilin, Coburn, Lori A., and Wilson, Keith T.

Published
2022
Full Text
View/download PDF

15. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis

Author

Gobert, Alain P., Boutaud, Olivier, Asim, Mohammad, Zagol-Ikapitte, Irene A., Delgado, Alberto G., Latour, Yvonne L., Finley, Jordan L., Singh, Kshipra, Verriere, Thomas G., Allaman, Margaret M., Barry, Daniel P., McNamara, Kara M., Sierra, Johanna C., Amarnath, Venkataraman, Tantawy, Mohammed N., Bimczok, Diane, Piazuelo, M. Blanca, Washington, M. Kay, Zhao, Shilin, Coburn, Lori A., and Wilson, Keith T.

Published
2021
Full Text
View/download PDF

16. Resolution of Gastric Cancer-Promoting Inflammation: A Novel Strategy for Anti-cancer Therapy

Author

Piazuelo, M. Blanca, Riechelmann, Rachel P., Wilson, Keith T., Algood, Holly M. Scott, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W, Series Editor, Galan, Jorge E, Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, and Backert, Steffen, editor

Published
2019
Full Text
View/download PDF

19. Remodeling of the gastric environment in Helicobacter pylori -induced atrophic gastritis

Author

Shuman, Jennifer H. B., primary, Lin, Aung Soe, additional, Westland, Mandy D., additional, Bryant, Kaeli N., additional, Piazuelo, M. Blanca, additional, Reyzer, Michelle L., additional, Judd, Audra M., additional, McDonald, W. Hayes, additional, McClain, Mark S., additional, Schey, Kevin L., additional, Algood, Holly M. S., additional, and Cover, Timothy L., additional

Published
2023
Full Text
View/download PDF

23. Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling

Author

Sierra, Johanna C., Piazuelo, M. Blanca, Luis, Paula B., Barry, Daniel P., Allaman, Margaret M., Asim, Mohammad, Sebrell, Thomas A., Finley, Jordan L., Rose, Kristie L., Hill, Salisha, Holshouser, Steven L., Casero, Robert A., Cleveland, John L., Woster, Patrick M., Schey, Kevin L., Bimczok, Diane, Schneider, Claus, Gobert, Alain P., and Wilson, Keith T.

Published
2020
Full Text
View/download PDF

25. Comprehensive molecular characterization of gastric adenocarcinoma

Author

Bass, Adam J, Thorsson, Vesteinn, Shmulevich, Ilya, Reynolds, Sheila M, Miller, Michael, Bernard, Brady, Hinoue, Toshinori, Laird, Peter W, Curtis, Christina, Shen, Hui, Weisenberger, Daniel J, Schultz, Nikolaus, Shen, Ronglai, Weinhold, Nils, Kelsen, David P, Bowlby, Reanne, Chu, Andy, Kasaian, Katayoon, Mungall, Andrew J, Robertson, A Gordon, Sipahimalani, Payal, Cherniack, Andrew, Getz, Gad, Liu, Yingchun, Noble, Michael S, Pedamallu, Chandra, Sougnez, Carrie, Taylor-Weiner, Amaro, Akbani, Rehan, Lee, Ju-Seog, Liu, Wenbin, Mills, Gordon B, Yang, Da, Zhang, Wei, Pantazi, Angeliki, Parfenov, Michael, Gulley, Margaret, Piazuelo, M Blanca, Schneider, Barbara G, Kim, Jihun, Boussioutas, Alex, Sheth, Margi, Demchok, John A, Rabkin, Charles S, Willis, Joseph E, Ng, Sam, Garman, Katherine, Beer, David G, Pennathur, Arjun, Raphael, Benjamin J, Wu, Hsin-Ta, Odze, Robert, Kim, Hark K, Bowen, Jay, Leraas, Kristen M, Lichtenberg, Tara M, Weaver, Stephanie, McLellan, Michael, Wiznerowicz, Maciej, Sakai, Ryo, Lawrence, Michael S, Cibulskis, Kristian, Lichtenstein, Lee, Fisher, Sheila, Gabriel, Stacey B, Lander, Eric S, Ding, Li, Niu, Beifang, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Brooks, Denise, Butterfield, Yaron SN, Carlsen, Rebecca, Chu, Justin, Chuah, Eric, Chun, Hye-Jung E, Clarke, Amanda, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Li, Haiyan A, Lim, Emilia, Ma, Yussanne, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Karen L, Ming Nip, Ka, and Schein, Jacqueline E

Subjects
Genetics, Digestive Diseases, Genetic Testing, Human Genome, Rare Diseases, Cancer, Good Health and Well Being, Adenocarcinoma, Female, Gene Expression Regulation, Neoplastic, Genome, Human, Herpesvirus 4, Human, Humans, Male, Mutation, Proteome, Stomach Neoplasms, Cancer Genome Atlas Research Network, General Science & Technology
Abstract

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.

Published
2014

27. Gastric coinfection with thiopeptide-positive Cutibacterium acnes decreases FOXM1 and pro-inflammatory biomarker expression in a murine model of Helicobacter pylori -induced gastric cancer

Author

Lunger, Courtney, primary, Shen, Zeli, additional, Holcombe, Hilda, additional, Mannion, Anthony J., additional, Dzink-Fox, JoAnn, additional, Kurnick, Susanna, additional, Feng, Yan, additional, Muthupalani, Sureshkumar, additional, Carrasco, Sebastian E., additional, Wilson, Keith T., additional, Peek, Richard M., additional, Piazuelo, M. Blanca, additional, Morgan, Douglas R., additional, Armijo, Amanda L., additional, Mammoliti, Melissa, additional, Wang, Timothy C., additional, and Fox, James G., additional

Published
2023
Full Text
View/download PDF

31. Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori -induced gastric injury via attenuation of both cag -mediated microbial virulence and proinflammatory host responses

Author

Noto, Jennifer M., primary, Piazuelo, M. Blanca, additional, Romero-Gallo, Judith, additional, Delgado, Alberto G., additional, Suarez, Giovanni, additional, Akritidou, Konstantina, additional, Girod Hoffman, Miguel, additional, Roa, Juan Carlos, additional, Taylor, Cormac T., additional, and Peek, Richard M., additional

Published
2023
Full Text
View/download PDF

36. The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.

Author

Thorell, Kaisa, Muñoz-Ramírez, Zilia Y., Wang, Difei, Sandoval-Motta, Santiago, Boscolo Agostini, Rajiv, Ghirotto, Silvia, Torres, Roberto C., Romero-Gallo, Judith, Krishna, Uma, Peek Jr, Richard M., Piazuelo, M. Blanca, Raaf, Naïma, Bentolila, Federico, Aftab, Hafeza, Akada, Junko, Matsumoto, Takashi, Haesebrouck, Freddy, Colanzi, Rony P., Bartelli, Thais F., and Nunes, Diana Noronha

Subjects
HELICOBACTER pylori, GENOMES, GASTRIC diseases, BACTERIAL genomes, AMERICANS, DRUG target, GENOMICS
Abstract

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics. The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

39. ACONITATE DECARBOXYLASE 1 IS A KEY REGULATOR OF COLITIS

Author

McNamara, Kara, primary, Latour, Yvonne, additional, Smith, Thaddeus, additional, Barry, Daniel, additional, Allaman, Margaret, additional, Delgado, Alberto, additional, Piazuelo, M Blanca, additional, Washington, Mary, additional, Zhao, Shilin, additional, Coburn, Lori, additional, Gobert, Alain, additional, and Wilson, Keith, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results