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5. Non-Cytotoxic Graphene Nanoplatelets Upregulate Cell Proliferation and Self-Renewal Genes of Mesenchymal Stem Cells.

Author

Nicoletti, Natália Fontana, Marinowic, Daniel Rodrigo, Perondi, Daniele, Budelon Gonçalves, João Ismael, Piazza, Diego, da Costa, Jaderson Costa, and Falavigna, Asdrubal

Subjects
CELL cycle regulation, MESENCHYMAL stem cells, CELL physiology, CELL cycle, GENE expression profiling
Abstract

Graphene nanoplatelets (UGZ–1004) are emerging as a promising biomaterial in regenerative medicine. This study comprehensively evaluates UGZ–1004, focusing on its physical properties, cytotoxicity, intracellular interactions, and, notably, its effects on mesenchymal stem cells (MSCs). UGZ–1004 was characterized by lateral dimensions and layer counts consistent with ISO standards and demonstrated a high carbon purity of 0.08%. Cytotoxicity assessments revealed that UGZ–1004 is non-toxic to various cell lines, including 3T3 fibroblasts, VERO kidney epithelial cells, BV–2 microglia, and MSCs, in accordance with ISO 10993–5:2020/2023 guidelines. The study focused on MSCs and revealed that UGZ–1004 supports their gene expression alterations related to self-renewal and proliferation. MSCs exposed to UGZ–1004 maintained their characteristic surface markers. Importantly, UGZ–1004 promoted significant upregulation of genes crucial for cell cycle regulation and DNA repair, such as CDK1, CDK2, and MDM2. This gene expression profile suggests that UGZ–1004 can enhance MSC self-renewal capabilities, ensuring robust cellular function and longevity. Moreover, UGZ–1004 exposure led to the downregulation of genes associated with tumor development, including CCND1 and TFDP1, mitigating potential tumorigenic risks. These findings underscore the potential of UGZ–1004 to not only bolster MSC proliferation but also enhance their self-renewal processes, which are critical for effective regenerative therapies. The study highlights the need for continued research into the long-term impacts of graphene nanoplatelets and their application in MSC-based regenerative medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Combined effect of montmorillonite Cloisite 30B and graphene nanoplatelets on high‐density polyethylene matrix under high strain rate dynamic compression.

Author

Grison, Vagner, Romanzini, Daiane, Dias, Rafael R., Pereira, Iaci M., Zattera, Ademir J., and Piazza, Diego

Abstract

Laminated polymer composites are widely used in ballistic barriers where polyethylene can be applied. The mechanical properties of polymers can be improved with the addition of nanofillers. Therefore, this work evaluates the effect of the combination of montmorillonite Cloisite 30B (OMt) and graphene (Gr) on the dynamics compression properties obtained from a split‐Hopkinson pressure bar (SHPB) test for nanostructured maleinized high‐density polyethylene (HDPE). The nanofillers are incorporated into the polymeric matrix in its molten state, and their dispersion is evaluated through x‐ray diffraction and transmission electron microscopy analyses. Thermal analysis, including differential scanning calorimetry and thermogravimetric analysis are performed. Additionally, the viscoelastic behavior of the materials is studied from the results of storage and loss modulus obtained by dynamic‐mechanical analysis. Under the SHPB test conditions, it is possible to evaluate the material stress–strain curve, identifying its yield point, compressive strength, and deformations to calculate the elastic stiffness and toughness of the material. The nanocomposite with 3% OMt and 0.75% Gr (wt.%) shows the highest average compressive strength and toughness values. Furthermore, this sample shows similar Tpeak temperature, improved crystallinity index, storage, and loss modulus, with similar glass transition temperature compared to the HDPE sample. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Mechanical behavior of carbon/glass polypropylene hybrid composites.

Author

Ost, Charles Antonio, Camargo, Monique Camille R., Rego, Artur S. C., de Bortoli, Bruna Farias, Ornaghi, Heitor Luiz, Piazza, Diego, and Zattera, Ademir José

Subjects
HYBRID materials, MALEIC anhydride, MANUFACTURING processes, DYNAMIC mechanical analysis, COUPLING agents (Chemistry), POLYPROPYLENE, OPTICAL fibers
Abstract

This research investigates the influence of graphene and some additives on the mechanical behavior of polypropylene (PP). Anhydride maleic coupling agent (MAPP), graphene nanoplatelets (GNPs), and glass fiber (GF) were incorporated into the polymer matrix. The incorporation of MAPP and/or GNP significantly improved the affinity between the PP matrix and fibers while altering the surface morphology. More than 60% of the fibers showed a dimension lower than 0.5 mm. The tensile strength increased from 27.45 to 41 MPa for the neat PP compared to one of the composites. The strength modulus varied from 0.5 to 0.9 GPa. Mechanical tests showed that the addition of MAPP improved the tensile toughness (from 27.45 to 41 N mm mm−2) by 49%, while the GF increased tensile strength, albeit reducing elongation at break. The dynamic mechanical thermal analysis uncovered distinct behavioral variations among fiber‐reinforced samples, particularly in modulus peak differences. In rheological assessment, the presence of GF notably increased viscosity within certain shear rate ranges (at 100 [1/s], the viscosity goes from 200 to 300 Pa s to neat PP for some composites). This research highlights how chosen additives can influence a PP homopolymer's properties, offering useful insights for practical material processing and design. Highlights: MAPP and GNP can increase PP and glass fiber interfacial bonding.Glass fiber raises tensile strength and decreases elongation.Sample with just GNP has a rougher surface, implying better energy dissipation.Glass fiber raises viscosity in the observed shear rate ranges.DMA demonstrates that MAPP and GNP have an influence on energy dissipation. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Global variation in the long-term outcomes of ypT0 rectal cancers

Author

Terrenato, Irene, Shinde, Rajesh S., Saklani, Avanish, Martins, Pedro, Videira, José Flávio, Bonci, Eduard-Alexandru, Achimas-Cadariu, Patriciu, Marinello, Franco, Espin, Eloy, Xenaki, Sofia, Lasithiotakis, Konstantinos, Rega, Daniela, Delrio, Paolo, Andrási, László, Lázár, György, Quattromani, Roberto, Elmore, Ugo, Branciforte, Martina Azzurra, Piazza, Diego, Sztipits, Tamás, Mersich, Tamás, Vigorita, Vincenzo, Ildefonso, Alberto San, Cianflocca, Desiree, Giuffrida, Maria Carmela, Biondi, Alberto, Persiani, Roberto, Košir, Jurij Aleš, Grosek, Jan, Rizzo, Gianluca, Coco, Claudio, Dieninyte-Misiune, Egle, Bausys, Rimantas, Bausys, Augustinas, Poskus, Tomas, Dupré, Aurélien, Muresan, Mihai-Stefan, Ionescu, Călin, Alyami, Mohammad, Cotte, Eddy, Candido, Francesca Di, Spinelli, Antonino, Lucarini, Alessio, Balducci, Genoveffa, Kisielewski, Michał, Pędziwiatr, Michał, Kroon, Hidde, Sammour, Tarik, Unger, Lukas, Stift, Anton, Marsanic, Patrizia, Muratore, Andrea, Uzunoglu, Mustafa Yener, Altintoprak, Fatih, Capponi, Michela Giulii, Poiasina, Elia, Brandl, Andreas, Aigner, Felix, Aparício, David, Leichsenring, Carlos, Corleone, Pio, Manzini, Nicolò de, Kabata, Paweł, Świerblewski, Maciej, Gallo, Gaetano, Trompetto, Mario, Negoi, Ionut, Beuran, Mircea, Souriti, Ahmad, Taylor, Gregory, De Luca, Raffaele, Simone, Michele, Bedford, Matthew, Charalampakis, Vasileios, Rajan, Shiv, Chaturvedi, Arun, Veltri, Marco, Parini, Dario, Turati, Luca, Sgroi, Giovanni, Bratu, Matei, Diaconescu, Bogdan, Slavchev, Mihail, Belev, Nikolay, Perfumo, Mariana Matzner, Rotholtz, Nicolas, Wajda, Justyna, Wysocki, Wojciech, Fernandez, Carmen Cagigas, Ruiz, Marcos Gomez, Marino, Serafino, Resta, Giuseppe, Ivanov, Tsvetomir, Dimitrov, Dobromir, Kaufmann, Claudia, Kafka-Ritsch, Reinhold, Yalkin, Omer, Ünal, Ali Ekrem, Loche, Giovanni Augusto, Cillara, Nicola, Colombo, Francesco, Foschi, Diego, Pollesel, Sara, Roviello, Franco, Lorenzon, Laura, Evrard, Serge, Beets, Geerard, Gonzalez-Moreno, Santiago, Kovacs, Tibor, D’Ugo, Domenico, and Polom, Karol

Published
2020
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12. PVDF/ZnO composite films for photocatalysis: A comparative study of solution mixing and melt blending methods

Author

Zanrosso, Crissie Dossin, Piazza, Diego, and Lansarin, Maria Azario

Subjects
Porosity -- Methods -- Comparative analysis, Catalysis -- Methods -- Comparative analysis, Povidone -- Methods -- Comparative analysis, Methylene blue -- Methods -- Comparative analysis, Polyvinylidene fluoride -- Comparative analysis -- Methods, Zinc oxide -- Comparative analysis -- Methods, Engineering and manufacturing industries, Science and technology
Abstract

Heterogeneous photocatalysis represents a solution for several environmental problems. However, achieving photocatalyst separation from reaction media on a large scale remains a challenge, one that might be overcome by the immobilization of photocatalysts into supports. To this end, composites of polyvinylidene fluoride and zinc oxide (ZnO) were prepared by three different techniques: solution mixing (SM) followed by Nonsolvent Induced Phase Separation; and melt blending at both low- and high-shear rates (LS and HS) in a rheometer and mixing chamber, respectively, to compare the resultant morphology in photocatalysis. Photocatalytic efficiency was assessed by methylene blue (MB) discoloration in a batch reactor liquid phase and by resazurin (RZ) reduction. The changes promoted by nanoparticle inclusion, processing conditions and UV effect were demonstrated by FTIR-ATR, XRD, DSC, and SEM. Results showed that ZnO incorporation was successful under all processing conditions, providing effective photocatalytic composites. However, samples prepared by SM had a twofold increase in discoloration efficiency and fourfold increase in surface photoactivity, when compared with LS or HS-produced samples, explained by its higher porosity of 88% [+ or -] 1.3%. The covering of the photocatalyst surface was also evident on SEM analysis for melt blended samples, further contributing to reduction in their photocatalytic activity. KEYWORDS blending, catalysis, composites, films, mixing, phase separation, 1 | INTRODUCTION Heterogeneous photocatalysis, an Advanced Oxidation Process, has attracted much attention for the synthesis of chemical compounds and environmental remediation, mainly as an alternative for resolving a number [...]

Published
2020
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13. Italian multi-society modified Delphi consensus on the definition and management of anastomotic leakage in colorectal surgery

Author

Spinelli, Antonino, Anania, Gabriele, Arezzo, Alberto, Berti, Stefano, Bianco, Francesco, Bianchi, Paolo Pietro, De Giuli, Maurizio, De Nardi, Paola, de Paolis, Paolo, Foppa, Caterina, Guerrieri, Mario, Marini, Pierluigi, Persiani, Roberto, Piazza, Diego, Poggioli, Gilberto, Pucciarelli, Salvatore, D’Ugo, Domenico, Renzi, Adolfo, Selvaggi, Francesco, Silecchia, Gianfranco, and Montorsi, Marco

Published
2020
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14. A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2

Author

Rossini, Roberta, Tarantini, Giuseppe, Musumeci, Giuseppe, Masiero, Giulia, Barbato, Emanuele, Calabrò, Paolo, Capodanno, Davide, Leonardi, Sergio, Lettino, Maddalena, Limbruno, Ugo, Menozzi, Alberto, Marchese, U.O. Alfredo, Saia, Francesco, Valgimigli, Marco, Ageno, Walter, Falanga, Anna, Corcione, Antonio, Locatelli, Alessandro, Montorsi, Marco, Piazza, Diego, Stella, Andrea, Bozzani, Antonio, Parolari, Alessandro, Carone, Roberto, and Angiolillo, Dominick J.

Published
2018
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16. A prospective non-randomized controlled, multicenter trial comparing Appendectomy and Conservative Treatment for Patients with Uncomplicated Acute Appendicitis (the ACTUAA study)

Author

Podda, Mauro, Serventi, Fernando, Mortola, Lorenzo, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Pisano, Marcello, Coppola, Massimiliano, Agresta, Ferdinando, Virdis, Francesco, Di Saverio, Salomone, Cillara, Nicola, Balestra, Francesco, Ottonello, Roberto, Lai, Antonio, Piro, Silverio, Argenio, Giulio, Gemini, Sergio, Pala, Miriam, Piras, Mario, Erdas, Enrico, Nicolosi, Angelo, Gordini, Luca, Podda, Francesco, Pisanu, Adolfo, Atzeni, Jenny, Poillucci, Gaetano, De Nisco, Carlo, Casciu, Luigi, Piano, Maurizio, Labate, Salvatore, Saba, Luca, Aresu, Simona, Azzinnaro, Antonio, Ioia, Giovanna, Turri, Luciano, Pulighe, Fabio, Anania, Marco, Canfora, Alfonso, Bottino, Vincenzo, Piazza, Diego, Luridiana, Gianluigi, Serra, Piergiorgio, Saba, Alessandra, Tuveri, Antonio, Pinna, Giovanni, Piredda, Antonella, Madeddu, Francesco, Caneva, Patrizia Dalla, Delogu, Daniele, Saliu, Antonella, Cogoni, Gianfranco, Deserra, Antonello, Pau, Renata, Cossu, Sergio, Canu, Luisa, Marcias, Gianni, Garau, Franco, Loi, Salvatore, Bellisano, Giulia, Presenti, Luigi, Maccioni, Antonio, Norcia, Giorgio, Piras, Emanuele, Fiume, Stefania, Pitzalis, Antonella, Bianco, Paola, Cappai, Mariangela, Cadeddu, Flavio Nicola, Manca, Alessandra, Occhioni, Giovanni, Rossi, Arianna Magoni, Rizzo, Salvatore, Centonze, Maurizio, Portolano, Vincenzo, Barbareschi, Mattia, Barrasi, Elena, Martorana, Martina, Ferro, Franca, Casarini, Claudia, Stella, Giorgio, Generoso, Paola, Rossi, Sabina, Abelli, Fabrizio, Casula, Laura, Gerardi, Chiara, Bertele’, Vittorio, and The ACTUAA Study Collaborative Working Group

Published
2017
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17. IPOD Study: Management of Acute Left Colonic Diverticulitis in Italian Surgical Departments

Author

Sartelli, Massimo, Binda, Gian Andrea, Brandara, Francesco, Borasi, Andrea, Feroci, Francesco, Vadalà, Salvatore, Labricciosa, Francesco M., Birindelli, Arianna, Luridiana, Gianluigi, Coccolini, Federico, Di Saverio, Salomone, Catena, Fausto, Ansaloni, Luca, Campanile, Fabio Cesare, Agresta, Ferdinando, Piazza, Diego, Anania, Gabriele, Caproli, Emanuele, Gasparrini, Marcello, Bordoni, Pierpaolo, Lucchi, Andrea, Scabini, Stefano, Picardi, Biagio, Sarro, Giuliano, Piccinini, Alice, Bedin, Natalino, Bussotti, Alessandro, De Angelis, Renato, Baiocchi, Gian Luca, Andreotti, Antonella, Cillara, Nicola, Petronio, Barbara, Grimaldi, Sergio, Biancafarina, Alessia, Somenzi, Dario, Costanzi, Andrea, Marvaso, Alberto, Canfora, Alfonso, Vasquez, Giorgio, Chiodo, Carlo, Nano, Mario, Cavicchi, Angelo, Ruffato, Alberto, Baccari, Paolo, Polastri, Roberto, Marsanic, Patrizia, Portale, Giuseppe, Gordini, Luca, Abongwa, Hariscine K, Pili, Michela, Turati, Luca, Nusca, Vittoria, Guercioni, Gianluca, Delogu, Leonardo Andrea, Robustelli, Umberto, Piras, Danilo, Serventi, Fernando, Prando, Daniela, Brunelli, Antonio, Zani, Bruno, Pintaldi, Salvatore, Verzelli, Augusto, Mulas, Silvia, Confalonieri, Gianmaria, Spagni, Giuditta, Crucitti, Antonio, Sagnotta, Andrea, Fiume, Stefania, Balestra, Francesco, Gatti, Matteo, Eugeni, Emilio, Carraro, Amedeo, Genna, Michele, Taglietti, Lucio, Azzinnaro, Antonio, Ferfoglia, Stefano, Miranda, Giuseppe, Tirone, Giuseppe, Luparello, Pietro, Berti, Stefano, Tutino, Roberta, De Manzoni Garberini, Andrea, Roscio, Francesco, Maglione, Valeria, Podda, Mauro, Ioia, Giovanna, Cantore, Fabrizio, Mazzalai, Franco, Cortesi, Francesco, Arcuri, Giacomo, Bellanova, Giovanni, Beltramo, Massimo, Chessa, Antonella, Coppola, Massimiliano, Gozzo, Davide, Harbi, Asaf, Minciotti, Edoardo, Pata, Francesco, Pinna, Giovanni, Testini, Mario, Vanella, Serafino, and IPOD study Collaborative Working Group

Published
2017
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23. The SIC-GIRCG 2013 Consensus Conference on Gastric Cancer

Author

De Manzoni, Giovanni, Baiocchi, Gian Luca, Framarini, Massimo, De Giuli, Maurizio, D’Ugo, Domenico, Marchet, Alberto, Nitti, Donato, Marrelli, Daniele, Morgagni, Paolo, Rinnovati, Andrea, Rosati, Riccardo, Roviello, Franco, Allieta, Rosaldo, Berti, Stefano, Bracale, Umberto, Capelli, Patrizio, Cavicchi, Angelo, Di Martino, Natale, Donini, Annibale, Filippini, Angelo, Francioni, Gianfranco, Frascio, Marco, Garofalo, Alfredo, Giulini, Stefano Maria, Grassi, Giovanni Battista, Innocenti, Paolo, Martino, Antonio, Mazzocconi, Gualtiero, Mazzola, Lorenzo, Montemurro, Severino, Palasciano, Nicola, Pantuso, Gianni, Pernthaler, Heinrich, Petri, Roberto, Piazza, Diego, Sacco, Rosario, Sgroi, Giovanni, Staudacher, Carlo, Testa, Michele, Vallicelli, Carlo, Vettoretto, Nereo, Zingaretti, Costantino, Capussotti, Lorenzo, Morino, Mario, and Verdecchia, Giorgio Maria

Published
2014
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31. Global variation in the long-term outcomes of ypT0 rectal cancers

Author

Lorenzon, Laura, primary, Evrard, Serge, additional, Beets, Geerard, additional, Gonzalez-Moreno, Santiago, additional, Kovacs, Tibor, additional, D’Ugo, Domenico, additional, Polom, Karol, additional, Terrenato, Irene, additional, Shinde, Rajesh S., additional, Saklani, Avanish, additional, Martins, Pedro, additional, Videira, José Flávio, additional, Bonci, Eduard-Alexandru, additional, Achimas-Cadariu, Patriciu, additional, Marinello, Franco, additional, Espin, Eloy, additional, Xenaki, Sofia, additional, Lasithiotakis, Konstantinos, additional, Rega, Daniela, additional, Delrio, Paolo, additional, Andrási, László, additional, Lázár, György, additional, Quattromani, Roberto, additional, Elmore, Ugo, additional, Branciforte, Martina Azzurra, additional, Piazza, Diego, additional, Sztipits, Tamás, additional, Mersich, Tamás, additional, Vigorita, Vincenzo, additional, Ildefonso, Alberto San, additional, Cianflocca, Desiree, additional, Giuffrida, Maria Carmela, additional, Biondi, Alberto, additional, Persiani, Roberto, additional, Košir, Jurij Aleš, additional, Grosek, Jan, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Dieninyte-Misiune, Egle, additional, Bausys, Rimantas, additional, Bausys, Augustinas, additional, Poskus, Tomas, additional, Dupré, Aurélien, additional, Muresan, Mihai-Stefan, additional, Ionescu, Călin, additional, Alyami, Mohammad, additional, Cotte, Eddy, additional, Candido, Francesca Di, additional, Spinelli, Antonino, additional, Lucarini, Alessio, additional, Balducci, Genoveffa, additional, Kisielewski, Michał, additional, Pędziwiatr, Michał, additional, Kroon, Hidde, additional, Sammour, Tarik, additional, Unger, Lukas, additional, Stift, Anton, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Uzunoglu, Mustafa Yener, additional, Altintoprak, Fatih, additional, Capponi, Michela Giulii, additional, Poiasina, Elia, additional, Brandl, Andreas, additional, Aigner, Felix, additional, Aparício, David, additional, Leichsenring, Carlos, additional, Corleone, Pio, additional, Manzini, Nicolò de, additional, Kabata, Paweł, additional, Świerblewski, Maciej, additional, Gallo, Gaetano, additional, Trompetto, Mario, additional, Negoi, Ionut, additional, Beuran, Mircea, additional, Souriti, Ahmad, additional, Taylor, Gregory, additional, De Luca, Raffaele, additional, Simone, Michele, additional, Bedford, Matthew, additional, Charalampakis, Vasileios, additional, Rajan, Shiv, additional, Chaturvedi, Arun, additional, Veltri, Marco, additional, Parini, Dario, additional, Turati, Luca, additional, Sgroi, Giovanni, additional, Bratu, Matei, additional, Diaconescu, Bogdan, additional, Slavchev, Mihail, additional, Belev, Nikolay, additional, Perfumo, Mariana Matzner, additional, Rotholtz, Nicolas, additional, Wajda, Justyna, additional, Wysocki, Wojciech, additional, Fernandez, Carmen Cagigas, additional, Ruiz, Marcos Gomez, additional, Marino, Serafino, additional, Resta, Giuseppe, additional, Ivanov, Tsvetomir, additional, Dimitrov, Dobromir, additional, Kaufmann, Claudia, additional, Kafka-Ritsch, Reinhold, additional, Yalkin, Omer, additional, Ünal, Ali Ekrem, additional, Loche, Giovanni Augusto, additional, Cillara, Nicola, additional, Colombo, Francesco, additional, Foschi, Diego, additional, Pollesel, Sara, additional, and Roviello, Franco, additional

Published
2020
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33. Image of the Month—Quiz Case

Author

Virzì, Giuseppe, Ragazzi, Salvatore, DʼAgati, Placido, Caputo, Sergio, Mascali, Davide, Ciaccio, Giovanni, Scaravilli, Francesco, and Piazza, Diego

Published
2008

38. 'Complex abdominal wall' management: evidence-based guidelines of the Italian Consensus Conference

Author

Piccoli, Micaela, Agresta, Ferdinando, Attinà, Grazia Maria, Amabile, Dalia, Marchi, Domenico, Bergamini, Carlo, Berta, Rossana, Boccia, Luigi, Cuccurullo, Diego, Fiscon, Valentino, Gossetti, Francesco, Ipponi, Pierluigi, Riccipetitoni, Giovanna, Rimini, Massimiliano, Russello, Domenico, Trapani, Vincenzo, Tricarico, Fausto, Tugnoli, Gregorio, Melotti, Gianluigi, Ansaloni, Luca, Barlera, Simona, Beghelli, Davide, Campanelli, Giampiero, Campanile, Fabio Cesare, Carlucci, Michele, Casarano, Salvatore, Chiara, Osvaldo, Chirletti, Piero, Corcione, Francesco, Crovella, Feliciano, Davoli, Marina, Gianetta, Ezio, Giordani, Stefano, Hervatin, Rita, Longoni, Mauro, Maida, Pietro, Marini, Pierluigi, Munegato, Gabriele, Negro, Paolo, Pelosi, Paolo, Piazza, Diego, Presenti, Luigi, Rea, Roberto, Sartelli, Massimo, Testini, Mario, Valeri, Andrea, Vettoretto, Nereo, and Vincenti, Rodolfo

Subjects
Complex abdominal wall, medicine.medical_specialty, Evidence-based practice, Abdominal compartment syndrome, Consensus Development Conferences as Topic, Meshes, 030230 surgery, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, medicine, Surgical emergency, Elective surgery, Laparotomy, Laparostomy, business.industry, General surgery, Emergency and elective treatment, Gold standard, Abdominal Wall, Surgery, Consensus conference, Surgical Mesh, medicine.disease, Consensus Conference, medicine.anatomical_structure, Italy, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Evidence-Based Practice, Practice Guidelines as Topic, Abdomen, Emergencies, Intra-Abdominal Hypertension, business
Abstract

To date, there is no shared consensus on a definition of a complex abdominal wall in elective surgery and in the emergency, on indications, technical details, complications, and follow-up. The purpose of the conference was to lay the foundations for a homogeneous approach to the complex abdominal wall with the primary intent being to attain the following objectives: (1) to develop evidence-based recommendations to define “complex abdominal wall”; (2) indications in emergency and in elective cases; (3) management of “complex abdominal wall”; (4) techniques for temporary abdominal closure. The decompressive laparostomy should be considered in a case of abdominal compartment syndrome in patients with critical conditions or after the failure of a medical treatment or less invasive methods. In the second one, beyond different mechanism, patients with surgical emergency diseases might reach the same pathophysiological end point of trauma patients where a preventive “open abdomen” might be indicated (a temporary abdominal closure: in the case of a non-infected field, the Wittmann patch and the NPWT had the best outcome followed by meshes; in the case of an infected field, NPWT techniques seem to be the preferred). The second priority is to create optimal both general as local conditions for healing: the right antimicrobial management, feeding—preferably by the enteral route—and managing correctly the open abdomen wall. The use of a mesh appears to be—if and when possible—the gold standard. There is a lot of enthusiasm about biological meshes. But the actual evidence supports their use only in contaminated or potentially contaminated fields but above all, to reduce the higher rate of recurrences, the wall anatomy and function should be restored in the midline, with or without component separation technique. On the other site has not to be neglected that the use of monofilament and macroporous non-absorbable meshes, in extraperitoneal position, in the setting of the complex abdomen with contamination, seems to have a cost effective role too. The idea of this consensus conference was mainly to try to bring order in the so copious, but not always so “evident” literature utilizing and exchanging the expertise of different specialists.

Published
2017

41. Seudoartrosis atrófica. Efecto de la aplicación de ondas de choque extracorpóreas en un modelo experimental en tibia de conejos.

Author

Del Vecchio, Javier, Galli Serra, Marcos, Martinez Gallino, Rafael, Guyot, Juan Pablo, Piazza, Diego Amadeo, Raimondi, Nicolás, Caloia, Martín, Santini Araujo, Eduardo, Autorino, Carlos, Del Vecchio, Javier, Galli Serra, Marcos, Martinez Gallino, Rafael, Guyot, Juan Pablo, Piazza, Diego Amadeo, Raimondi, Nicolás, Caloia, Martín, Santini Araujo, Eduardo, and Autorino, Carlos

Abstract

Introduction: The effects of extracorporeal shock wave therapy (ESWT) have been investigated in human osteoblasts, fracture foci, nonunion and periosteum cells. The best results of nonunion treatment with ESWT have been documented for hypertrophic type. The objective of this study was to investigate the effects of ESWT in an atrophic nonunion focus generated in a rabbit tibia model. Methods: Three groups were included: A, fractures receiving ESWT; B (“control”), fractures not receiving ESWT, and C, no fractures (right leg). A total of 37 New Zealand white and skeletally mature rabbits (cuniculus NV) were treated. Periosteum was cauterized using bipolar electrocautery at 20 mm in both bone stumps (proximal and distal). Then ESWT was applied in one session. Staining with hematoxylin-eosin was used. A biomechanical analysis with a 3-point loading system was performed. Maximum load and elastic modulus were evaluated in each group. Results: Histological study evidenced signs of union (periosteal and endosteal fracture callus) which were considerably larger in tibias of Group A (treated with ESWT) as compared to the control group (Group B). Conclusion: In an experimental model of atrophic pseudarthrosis caused by electrocautery in tibias of rabbits, significant radiographic and histological changes were observed after focus intervention with the application of ESWT., Introducción: Los efectos de las ondas de choque extracorpóreas se han investigado en osteoblastos humanos, focos fracturarios, seudoartrosis y células periósticas. Los mejores resultados del tratamiento de la seudoartrosis con ondas de choque extracorpóreas se han documentado para seudoartrosis hipertróficas. El objetivo de este estudio fue investigar el efecto de la terapia con ondas de choque extracorpóreas sobre un foco de seudoartrosis “atrófica” generado en tibia de conejo. Métodos: Se establecieron tres grupos: A, fracturados sometidos a ondas de choque extracorpóreas; B (“control”), fracturados no sometidos a ondas de choque y C, no fracturados (pierna derecha). Se trataron 37 conejos (cuniculus NV) blancos y esqueléticamente maduros de Nueva Zelanda. Se practicó la cauterización del periostio con electrobisturí bipolar en una extensión de 20 mm, en ambos muñones óseos (proximal y distal). Luego se aplicaron ondas de choque extracorpóreas en una sola sesión. Se realizaron tinciones con hematoxilina-eosina. Se efectuó el análisis biomecánico con un método de carga a “3 puntos”. Se estudiaron la carga máxima aplicada y el módulo de elasticidad para cada grupo. Resultados: El estudio histológico permitió registrar signos de consolidación –callo fracturario perióstico y endostal– considerablemente mayores en las tibias de los animales del grupo A (tratado con ondas de choque extracorpóreas) que en las del grupo B “control”. Conclusión: En un modelo experimental original de seudoartrosis atrófica generada por electrocauterización en tibia de conejos, se registraron cambios significativos radiográficos e histológicos luego de la intervención del foco mediante ondas de choque extracorpóreas

Published
2017

42. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, II kirurgian klinikka, Department of Surgery, and Clinicum

Subjects
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, INTENSIVE-CARE-UNIT, SPECTRUM-BETA-LACTAMASE, VENTILATOR-ASSOCIATED PNEUMONIA, CLINICAL-PRACTICE GUIDELINES, GRAM-NEGATIVE BACTERIA, CLOSTRIDIUM-DIFFICILE INFECTION, BLOOD-STREAM INFECTIONS, 3126 Surgery, anesthesiology, intensive care, radiology, CRITICALLY-ILL PATIENTS, VANCOMYCIN-RESISTANT ENTEROCOCCI
Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

43. Obtenção e caracterização de tintas em pó base resina epóxi contendo montmorilonitas modificadas com cério

Author

Piazza, Diego, Ferreira, Carlos Arthur, and Zattera, Ademir José

Subjects
Cério, Tinta em pó, Montmorilonita, Nanocompósitos, Resina epóxi
Abstract

Revestimentos orgânicos têm sido amplamente utilizados para a proteção à corrosão de substratos metálicos devido ao seu custo favorável e facilidade de aplicação. O uso de nanopartículas, mesmo que em baixas concentrações, apresenta-se como uma solução eficiente para aumentar as propriedades de barreira e resistência dos revestimentos orgânicos. A montmorilonita (MMT) é a fase inorgânica mais utilizada na obtenção de nanocompósitos poliméricos. O óxido de cério quando incorporado em revestimentos, além de não apresentar problemas ambientais, fornece uma eficiente proteção à corrosão. A desaceleração no crescimento do setor de tintas em pó e a necessidade de novos produtos tecnológicos relacionados à área dos nanocompósitos poliméricos constituem um campo propício para o desenvolvimento de um novo segmento: tintas em pó nanoestruturadas. O presente trabalho teve por objetivo o desenvolvimento de uma tinta em pó base epóxi a partir de uma formulação padrão comercial de tinta em pó com a adição de diferentes teores (2, 4 e 8 % (m/m)) de diferentes tipos de argilas montmorilonitas (MMT-Na+, OMMT-15A, OMMT-30B), modificadas com nitrato de cério IV e amônia. A incorporação, das argilas modificadas (MMT-NaCe, OMMT-15ACe, e OMMT-30BCe), na formulação das tintas em pó base epóxi, foi realizada em extrusora duplarrosca co-rotante no estado fundido. As tintas em pó foram aplicadas em substrato metálico de aço-carbono por pulverização elestrostática A eficiência da incorporação do cério na estrutura das argilas foi confirmada na análise elementar por espectroscopia de raios-X por dispersão de energia (EDS), nos difratogramas de difração de raios-X (DRX), e também, por espectroscopia no infravermelho por transformada de Fourier (FTIR). Nas análises de MET e DRX das tintas constatou-se que a adição da argila OMMT-15ACe resultou em um nanocompóstico com estrutura predominantemente esfoliada e uma distribuição homogênea da carga na matriz polimérica. O aumento do teor das argilas OMMT-15ACe e OMMT-30BCe nos revestimentos resultou na redução da resistência ao impacto. Constatou-se, através das técnicas de caracterização deste trabalho, que a argila MMT-NaCe não interferiu no desempenho dos revestimentos quanto às propriedades físicas e mecânicas. As medidas de migração subcutânea, realizadas após o ensaio de exposição à névoa salina, indicaram a presença de revestimentos com bom desempenho anticorrosivo para todas as amostras contendo os diferentes tipos e teores de argila. Através da análise de espectroscopia de impedância eletroquímica, constatou-se um melhor desempenho anticorrosivo para os revestimentos contendo a argila do tipo OMMT-15ACe. Organic coatings have been widely used for the corrosion protection of metal substrates due to their favorable cost and ease of application. The use of nanoparticles, even at low concentrations, is an efficient solution to increase the barrier and resistance properties of organic coatings. The montmorillonite (MMT) is the most used inorganic phase to obtain polymeric nanocomposites. Cerium oxide when incorporated into coatings, in addition to not presenting environmental problems, provides an efficient corrosion protection. The deceleration in the growth of the powder coating industry and the need for new technological products related to the area of polymer nanocomposites constitute a propitious field for the development of a new segment: nanostructured powder coatings. The objective of the present work was to develop an epoxy-based powder coating on a standard commercial formulation of powder coatin with the addition of different grades (2, 4 and 8% (w/w)) of different types of clays Montmorillonites (MMT-Na+, OMMT-15A, and OMMT-30B), modified with (NH4)2Ce(NO3)6 The incorporation of the modified clays (MMT-NaCe, OMMT-15ACe, and OMMT-30BCe) in the formulation of the epoxy-based powder coating was performed in co-rotating co-rotating twin-screw extruder. Powder coatings were applied on electrostatic spray carbon steel metal substrate The efficiency of the incorporation of cerium into the clay structure was confirmed by elemental analysis by energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and also by infrared spectroscopy of Fourier (FTIR). In the MET and XRD analyzes of the coatings, it was found that the addition of the OMMT-15ACe clay resulted in a predominantly exfoliated nanocomphatic structure and a homogeneous distribution of the charge in the polymer matrix. Increasing the content of the OMMT-15ACe and OMMT-30BCe clays in the coatings resulted in the reduction in impact strength. It was verified, through the characterization techniques of this work, that MMT-NaCe clay did not interfere in the performance of the coatings regarding the physical and mechanical properties. The subcutaneous migration measurements, performed after the salt spray exposure, indicated the presence of coatings with good anti-corrosion performance for all samples containing the different types and contents of clay. Through the analysis of electrochemical impedance spectroscopy, a better anticorrosive performance was found for coatings containing OMMT-15ACe clay.

Published
2016

44. Seudoartrosis atrófica. Efecto de la aplicación de ondas de choque extracorpóreas en un modelo experimental en tibia de conejos. [Atrophic pseudoarthrosis. Effect of extracorporeal shock waves aplication in an experimental model in tibia of rabbits].

Author

Del Vecchio, Jorge Javier, primary, Galli Serra, Marcos, additional, Martínez Gallino, Rafael, additional, Guyot, Juan Pablo, additional, Piazza, Diego Amadeo, additional, Raimondi, Nicolás, additional, Caloia, Martín, additional, Santini Araujo, Eduardo, additional, and Autorino, Carlos María, additional

Published
2017
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47. ESTUDO DO EFEITO DA ADIÇÃO DE DIFERENTES TEORES DE ARGILAS MONTMORILONITA E MICA MUSCOVITA NO COMPORTAMENTO PROTETIVO DE TINTAS EM PÓ BASE EPÓXI NA APLICADAS SOBRE AÇO AISI 1008.

Author

da Costa Ferreira, Patrícia, Rossa Beltrami, Lilian Vanessa, Piazza, Diego, Raquel Kunst, Sandra, and Jozé Zattera, Ademir

Subjects
SALT spray testing, POLYMERIC nanocomposites, CONTACT angle, EPOXY resins, POWDER coating, MONTMORILLONITE
Abstract

Copyright of Tecnologia em Metalurgia, Materiais e Mineração is the property of Associacao Brasileira de Metalurgia e Materiais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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48. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

49. Antimicrobials

Author

University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

50. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, primary, Weber, Dieter G., additional, Ruppé, Etienne, additional, Bassetti, Matteo, additional, Wright, Brian J., additional, Ansaloni, Luca, additional, Catena, Fausto, additional, Coccolini, Federico, additional, Abu-Zidan, Fikri M., additional, Coimbra, Raul, additional, Moore, Ernest E., additional, Moore, Frederick A., additional, Maier, Ronald V., additional, De Waele, Jan J., additional, Kirkpatrick, Andrew W., additional, Griffiths, Ewen A., additional, Eckmann, Christian, additional, Brink, Adrian J., additional, Mazuski, John E., additional, May, Addison K., additional, Sawyer, Rob G., additional, Mertz, Dominik, additional, Montravers, Philippe, additional, Kumar, Anand, additional, Roberts, Jason A., additional, Vincent, Jean-Louis, additional, Watkins, Richard R., additional, Lowman, Warren, additional, Spellberg, Brad, additional, Abbott, Iain J., additional, Adesunkanmi, Abdulrashid Kayode, additional, Al-Dahir, Sara, additional, Al-Hasan, Majdi N., additional, Agresta, Ferdinando, additional, Althani, Asma A., additional, Ansari, Shamshul, additional, Ansumana, Rashid, additional, Augustin, Goran, additional, Bala, Miklosh, additional, Balogh, Zsolt J., additional, Baraket, Oussama, additional, Bhangu, Aneel, additional, Beltrán, Marcelo A., additional, Bernhard, Michael, additional, Biffl, Walter L., additional, Boermeester, Marja A., additional, Brecher, Stephen M., additional, Cherry-Bukowiec, Jill R., additional, Buyne, Otmar R., additional, Cainzos, Miguel A., additional, Cairns, Kelly A., additional, Camacho-Ortiz, Adrian, additional, Chandy, Sujith J., additional, Che Jusoh, Asri, additional, Chichom-Mefire, Alain, additional, Colijn, Caroline, additional, Corcione, Francesco, additional, Cui, Yunfeng, additional, Curcio, Daniel, additional, Delibegovic, Samir, additional, Demetrashvili, Zaza, additional, De Simone, Belinda, additional, Dhingra, Sameer, additional, Diaz, José J., additional, Di Carlo, Isidoro, additional, Dillip, Angel, additional, Di Saverio, Salomone, additional, Doyle, Michael P., additional, Dorj, Gereltuya, additional, Dogjani, Agron, additional, Dupont, Hervé, additional, Eachempati, Soumitra R., additional, Enani, Mushira Abdulaziz, additional, Egiev, Valery N., additional, Elmangory, Mutasim M., additional, Ferrada, Paula, additional, Fitchett, Joseph R., additional, Fraga, Gustavo P., additional, Guessennd, Nathalie, additional, Giamarellou, Helen, additional, Ghnnam, Wagih, additional, Gkiokas, George, additional, Goldberg, Staphanie R., additional, Gomes, Carlos Augusto, additional, Gomi, Harumi, additional, Guzmán-Blanco, Manuel, additional, Haque, Mainul, additional, Hansen, Sonja, additional, Hecker, Andreas, additional, Heizmann, Wolfgang R., additional, Herzog, Torsten, additional, Hodonou, Adrien Montcho, additional, Hong, Suk-Kyung, additional, Kafka-Ritsch, Reinhold, additional, Kaplan, Lewis J., additional, Kapoor, Garima, additional, Karamarkovic, Aleksandar, additional, Kees, Martin G., additional, Kenig, Jakub, additional, Kiguba, Ronald, additional, Kim, Peter K., additional, Kluger, Yoram, additional, Khokha, Vladimir, additional, Koike, Kaoru, additional, Kok, Kenneth Y. Y., additional, Kong, Victory, additional, Knox, Matthew C., additional, Inaba, Kenji, additional, Isik, Arda, additional, Iskandar, Katia, additional, Ivatury, Rao R., additional, Labbate, Maurizio, additional, Labricciosa, Francesco M., additional, Laterre, Pierre-François, additional, Latifi, Rifat, additional, Lee, Jae Gil, additional, Lee, Young Ran, additional, Leone, Marc, additional, Leppaniemi, Ari, additional, Li, Yousheng, additional, Liang, Stephen Y., additional, Loho, Tonny, additional, Maegele, Marc, additional, Malama, Sydney, additional, Marei, Hany E., additional, Martin-Loeches, Ignacio, additional, Marwah, Sanjay, additional, Massele, Amos, additional, McFarlane, Michael, additional, Melo, Renato Bessa, additional, Negoi, Ionut, additional, Nicolau, David P., additional, Nord, Carl Erik, additional, Ofori-Asenso, Richard, additional, Omari, AbdelKarim H., additional, Ordonez, Carlos A., additional, Ouadii, Mouaqit, additional, Pereira Júnior, Gerson Alves, additional, Piazza, Diego, additional, Pupelis, Guntars, additional, Rawson, Timothy Miles, additional, Rems, Miran, additional, Rizoli, Sandro, additional, Rocha, Claudio, additional, Sakakhushev, Boris, additional, Sanchez-Garcia, Miguel, additional, Sato, Norio, additional, Segovia Lohse, Helmut A., additional, Sganga, Gabriele, additional, Siribumrungwong, Boonying, additional, Shelat, Vishal G., additional, Soreide, Kjetil, additional, Soto, Rodolfo, additional, Talving, Peep, additional, Tilsed, Jonathan V., additional, Timsit, Jean-Francois, additional, Trueba, Gabriel, additional, Trung, Ngo Tat, additional, Ulrych, Jan, additional, van Goor, Harry, additional, Vereczkei, Andras, additional, Vohra, Ravinder S., additional, Wani, Imtiaz, additional, Uhl, Waldemar, additional, Xiao, Yonghong, additional, Yuan, Kuo-Ching, additional, Zachariah, Sanoop K., additional, Zahar, Jean-Ralph, additional, Zakrison, Tanya L., additional, Corcione, Antonio, additional, Melotti, Rita M., additional, Viscoli, Claudio, additional, and Viale, Perluigi, additional

Published
2016
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