1. Effect of aortic valve phenotype and sex on aorta dilation in patients with aortic stenosis.
- Author
-
Fleury, Marie-Ange, Tastet, Lionel, Bernard, Jérémy, Shen, Mylène, Capoulade, Romain, Abdoun, Kathia, Bédard, Élisabeth, Arsenault, Marie, Chetaille, Philippe, Beaudoin, Jonathan, Bernier, Mathieu, Salaun, Erwan, Côté, Nancy, Pibarot, Philippe, and Hecht, Sébastien
- Subjects
Aortic Diseases ,Congenital Abnormalities ,Echocardiography ,Heart Valve Diseases ,Humans ,Male ,Aortic Valve Stenosis ,Female ,Phenotype ,Aged ,Aortic Valve ,Sex Factors ,Disease Progression ,Echocardiography ,Doppler ,Bicuspid Aortic Valve Disease ,Dilatation ,Pathologic ,Follow-Up Studies ,Middle Aged ,Prospective Studies ,Risk Factors ,Aorta ,Aged ,80 and over ,Severity of Illness Index - Abstract
BACKGROUND: Bicuspid aortic valve (BAV) is often associated with a concomitant aortopathy. However, few studies have evaluated the effect of the aortic valve (AV) phenotype on the rate of dilation of the aorta. This study aimed to compare the progression rate of aorta dimensions according to AV phenotype (BAV vs tricuspid AV (TAV)), fusion type and sex in patients with aortic stenosis (AS). METHODS: 310 patients with AS (224 TAV and 86 BAV) recruited in the Metabolic Determinants of the Progression of Aortic Stenosis study (PROGRESSA, NCT01679431) were included in this analysis. Doppler echocardiography was performed annually to assess AS severity and measure ascending aorta (AA) dimensions. Baseline and last follow-up visit measurements were used to assess the annualised change. RESULTS: Median AA annualised change was larger in BAV versus TAV (0.33±0.65 mm/year vs 0.21±0.56 mm/year, p=0.04). In the whole cohort, BAV phenotype and higher low-density lipoprotein (LDL) levels were significantly associated with fast progression of AA dilation in univariate analysis (OR 1.80, 95% CI 1.08 to 2.98, p=0.02; 1.37, 95% CI 1.04 to 1.80, p=0.03, respectively). AA dilation rate did not vary according to the BAV subtype (p=0.142). Predictors of AA progression rate were different between valve phenotypes, with higher apolipoprotein B/apolipoprotein A-I ratio, higher baseline peak aortic jet velocity (Vpeak) and smaller baseline AA diameter in the TAV cohort (all p
- Published
- 2024