218 results on '"Pica, Roberta"'
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2. I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease
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Gornet, Jean-Marc, Beaugerie, Laurent, Shaji, Sebastian, Peyrin-Biroulet, Laurent, Reimund, Jean-Marie, Hebuterne, Xavier, Amiot, Aurélien, Armelao, Franco, Blanc, Pierre, Papi, Claudio, De Chambrun, Guillaume Pineton, Roblin, Xavier, Chu, Karmiris, Konstantinos, Shariq, Sohail, Viazis, Nikolaos, Limdi, Jimmy, Eder H, Piotr, Michalopoulos, Georgios, Bell, Andrew, Biancone, Livia, Dewitte, Marie, Mazhar, Zia, Franchimont, Denis, Nancey, Stephane, Macaigne, Gilles, Principi, Maria Beatrice, Fumery, Mathurin, Parkes, Gareth, Valats, Jean-Christophe, Doherty, Glen, Bouguen, Guillaume, Molnar, Tamás, Tsai, Hersin, Gangi, Mohsin, Pedersen, Natalia, Heluwaert, Frédéric, Shenderey, Richard, Zeissig, Sebastian, Butterworth, Jeffrey, Castiglione, Fabiana, Corless, Lynsey, Zallot, Camille, Baert, Filip, Singh, Salil, Sonwalkar, Sunil, Clayton, Elizabeth, Rahier, Jean-François, Vani, Deven, Bellaiche, Guy, De Vos, Martine, Kirchgesner, Julien, Kopylov, Uri, Lobaton, Triana, Locher, Christophe, Mantzaris, Gerassimos, Abouda, George, Smith, Katie, Sprakes, Michael, Theodoropoulou, Angeliki, Wesley, Emma, Bonnet, Joëlle, Elphick, David, Gilletta, Cyrielle, Gordon, John, Laharie, David, Nakad, Antoine, Orlando, Ambrogio, Dubois, Patrick, Hasselblatt, Peter, Michiels, Christophe, Preston, Cathryn, Staicu, Anca, Vuitton, Lucine, Kaassis, Mehdi, Speight, Ally, Ghosh, Deb, Löwenberg, Mark, Mathieu, Nicolas, Pelletier, Anne-Laure, Phillips, Anne, Magro, Fernando, Altwegg, Romain, Avni, Irit, biron, Landy, Jonathon, Nachury, Maria, Shenoy, Achuth, Trang, Caroline, Abitbol, Vered, Bamias, Georgios, Farkas, Klaudia, Maaser, Christian, Shitrit, Ariella, Siegmund, Britta, Filippi, Jérôme, O'morain, Colm, Yanai, Henit, Costes, Laurent, Hobday, David, Szepes, Zoltán, Calabrese, Emma, Dallal, Helen, Fung, Michael, Ramadas, Arvind, Baburajan, Bijay, Koss, Konrad, Barberis, Christophe, Buisson, Anthony, Amil, Morgane, Balestrieri, Paola, Johnson, Matthew, Tzouvala, Maria, Viennot, Stéphanie, Nagy, Ferenc, Thompson, Nick, Alric, Laurent, Samuel, Sunil, Bourrier, Anne, Chanteloup, Elise, Del Tedesco, Emilie, Harbord, Marcus, Lobo, Alan, Myers, Sally, Pollok, Richard, Ahmad, Tariq, Chaudhary, Rakesh, Karakoidas, Christos, Soliman, Ashraf, Stefanescu, Carmen, Theocharis, Georgios, Branden, Stijn Vanden, Beltran, Belén, Bouhnik, Yoram, Bourreille, Arnaud, Branco, Joana, Colleypriest, Ben, Eliakim, Rami, Knight, Paul, O'toole, Aoibhlinn, Robles, Virgina, Triantafyllou, Konstantinos, Bosca, Marta Maia, Lambrecht, Guy, Mosquera, Lucia Marquez, Panter, Simon, Pappa, Aikaterini, Simon, Marion, Sivaji, Ganesh, Bellanger, Christophe, Belle, Arthur, Borruel, Natalia, Egan, Laurence, Peeters, Harald, Sharpstone, Daniel, Arasaradnam, Ramesh, Benitez, José Manuel, Dahlerup, Jens Frederik, Giouleme, Olga, Gisbert, Javier P., Helwig, Ulf, Minguez, Miguel, Tsironi, Eftychia, Variola, Angela, Allen, Patrick, Boivineau, Lucille, Cole, Andy, Dib, Nina, Gomollon, Fernando, Johnston, Richard, Katsanos, Konstantinos, Kennedy, Nick, Kiszka-Kanowitz, Marianne, Marin-Jimenez, Ignacio, Miheller, Pál, Nos, Pilar, Saraj, Othman, Vinter-Jensen, Lars, Zittan, Eran, Baudry, Clotilde, Calvet, Xavier, Cazelles-Boudier, Marie-Christine, Coenegrachts, Jean-Louis, Cullen, Garret, Daperno, Marco, Dhar, Anjan, Gerard, Romain, Jensen, Nanna, Maharshak, Nitsan, Mcalindon, Mark, Mcloughlin, Simon, Parkes, Miles, Patel, Kamal, Peixoto, Armando, Polymeros, Dimitrios, Portela, Francisco, Rocca, Rodolfo, Seksik, Philippe, Subramanian, Sreedhar, Tennenbaum, Ruth, Atreya, Raja, Bachmann, Oliver, Berger, Arthur, Bor, Renáta, Buckley, Maire, Carpio, Daniel, Chaparro, María, Costa, Francesco, Domenech, Eugeni, Esteve, Maria, Foley, Stephen, Guardiola, Jordi, Koutroubakis, Ioannis, Kuehbacher, Tanja, Landman, Cécilia, Lavagna, Alessandro, Manceñido, Noemí, Mañosa, Míriam, Martín-Arranz, Maria Dolores, Plastaras, Laurianne, Scribano, Maria Lia, Sengupta, Subhasish, Teich, Nils, Tran-Minh, My-Linh, Zampeli, Evanthia, Amininejad, Leila, Arroyo, Teresa, Attar, Alain, Backman, Ann-Sofie, Bálint, Anita, Beckly, John, Ben Horin, Shomron, Bernardo, Sónia, Caillo, Ludovic, Caron, Bénédicte, Shanika de Silva, María, FábiáN, Anna, Fiorino, Gionata, Gutierrez, Ana, Lahat, Adi, Masmoudi, Mohamed, Mendolaro, Marco, Muls, Vinciane, Poullenot, Florian, Probert, Christopher, Reenaers, Catherine, Rutka, Mariann, Sarwari, Zaman, Sayer, Joanne, Sicilia, Beatriz, Sousa, Helena, van Kemseke, Catherine, Zabana, Yamile, Astegiano, Marco, Banim, Paul, Bettenworth, Dominik, Boualit, Médina, Brodersen, Jacob Broder, Christidou, Angeliki, Cooney, Rachel, Pinto, João Cortez, Cravo, Portugal Marília, Cremer, Anneline, Danese, Silvio, di Sabatino, Antonio, Fallingborg, Jan, Ferronato, Antonio, Planella, Esther Garcia, Gupta, Sanjay, Halfvarson, Jonas, Israeli, Eran, Kestenbaum, Samantha, Larsen, Lone, Macken, Elisabeth, Mathou, Nicoletta, Milassin, Ágnes, Pofelski, Joanna, Ricci, Chiara, Rodriguez-Moranta, Francisco, Schmidt-Lauber, Martin, Shaw, Ian, Soares, Marta, Soliman, Heithem, Triantos, Christos, Zografos, Konstantinos, Agrawal, Anurag, Armuzzi, Alessandro, Aubourg, Alexandre, Acosta, Manuel Barreiro-de, Barrio, Jesús, Bergemalm, Daniel, Bermejo, Fernando, Bodini, Giorgia, Bohr, Johan, Bossuyt, Peter, Christodoulou, Dimitrios, Claessens, Christophe, Collins, Paul, de Francisco, Ruth, Garcia, Santiago, Georgopoulos, Sotirios, Goutorbe, Felix, Kalantzis, Chrisostomos, Kourikou, Anastasia, Mace, Vincent, Malamut, Georgia, Ministro, Paula, Larmurier, Isabelle Nion, Ricart, Elena, Serrero, Mélanie, Sheridan, Juliette, Weimers, Petra, Andersen, Vibeke, Arroja, Bruno, Bokemeyer, Bernd, Bujanda, Luis, Degand, Thibault, Eriksson, Carl, Garceau, Cécile, Glerup, Henning, Goren, Idan, Jackson, Lucina, Koch, Stéphane, Mesonero, Francisco, Ordas, Ingrid, Riviere, Pauline, Saibeni, Simone, Soares, João, Tavernier, Noémie, Theede, Klaus, Ungar, Bella, Bästlein, Elke, Gasbarrini, Antonio, Protopapas, Andreas, Reindl, Wolfgang, Bossa, Fabrizio, Hart, Ailsa, Heil, Franz-Josef, O'Connor, Anthony, Oldenburg, Bas, Pastorelli, Luca, Stephen patchett, Ramakrishnan, Subramaniam, de Caestecker, John, Echarri, Ana, Kevans, David, Büning, Jürgen, Coelho, Rosa, Jansen, Jeroen, Koslowski, Benjamin, Wells, Christopher, Ceballos, Daniel, König, Ingrid, Padmanabhan, Hari, Patani, Timi, Qureshi, Raheel, Zagorowicz, Edyta, Allez, Matthieu, Archavlis, Emmanouil, Bonnet, Delphine, Guidi, Luisa, Mcnamara, Deirdre, Vernia, Piero, Weidenhiller, Michael, Alon, Lang, Boysen, Trine, Delattre, Charlotte, Farrell, Richard, Krüger, Rolf-Achim, Paupard, Thierry, Vind, Ida, Caprioli, Flavio, Gancho, Vladimir, Quentin, Vincent, Avidan, Benjamin, D’Haens, Geert, Mccarthy, Jane, Snook, Jonathon, Soufleris, Konstantinos, Zerbib, Frank, Carter, Dan, Depla, Annekatrien, Eisenbach, Thomas, Fries, Walter, Grammatikos, Nikolaos, Ilegems, Saskia, Lopez-Sanroman, Antonio, Moreau, Jacques, Riegler, Gabriele, Rietdijk, Svend, Rocha, Marta, Rosa, Isabelle, Ryan, Barbara, Yeremenko, Yelena, Boruchowicz, Arnaud, Damião, Filipe, Laoudi, Foteini, Lügering, Andreas, Macarri, Giampiero, Thomopoulos, Konstantinos, Barros, Luísa, Blixt, Thomas, Garros, Aurélien, Khorrami, Sam, Sokol, Harry, Sturm, Andreas, Livovsky, Dan, Maul, Jochen, Miks, Heinrich, Papadopoulos, Vasileios, Schmidt, Carsten, Snir, Yifat, Svenningsen, Lise, Ahmed, Wafaa, Broitman, Yelena, Cuillerier, Emmanuel, Kant, Prashant, Leyden, Jan, Lichtenstein, Lev, Lopes, Susana, Martineau, Chloé, Mulcahy, Hugh, Schweitzer, Axel, Van Schaik, Fiona, Banai, Hagar, Danion, Pauline, Dulery, Charlotte, Fidder, Herma, Gay, Claire, Hagege, Hervé, Harnois, Florence, Jørgensen, Søren Peter, Müller-Ziehm, Jens, Oikonomou, Michail, Palmela, Carolina, Schulze/Röske, Jörg, Smith, Mark, Thurm, Tamar, Bresso, Francesca, Brixi, Hedia, Jones, John, Macmathuna, Padraig, Painchart, Claire, Ron, Yulia, Vester-Andersen, Marianne, Alexandrino, Gonçalo, Börner, Norbert, Cardoso, Mariana, Chagas, Cristina, Dignaß, Axel, Dotan, Iris, Hedin, Charlotte, Karatzas, Pantelis, Kasapidis, Panagiotis, Palatka, Károly, Sakizlis, Georgios, Wilson, Ana, Bosanko, Nick, Caldeira, Paulo, Gagniere, Charlotte, Libier, Louise, Meunier, Camille, Moog, Gero, Pasquion, Audrey, Pica, Roberta, Akbar, Ayesha, Arab, Nadia, Cadiot, Guillaume, Carvalho, João, Charpignon, Claire, Fellermann, Laus, Fishman, Sigal, Fraser, Gerald, Gluck, Nathan, Hoesl, Mark, Kierkus, Jarosław, Klopocka, Maria, Arranz, Eduardo Martin, Menchen, Luis, Nikolaus, Susanna, Petrache, Anca, Ponsioen, Cyriel, Riestra, Sabino, Robledo, Pilar, Rodriguez, Cristina, Samer, Misheal, Tischer, Matthias, Wypych, Joanna, Baudon, Julien, Bezzio, Cristina, Boschetti, Gilles, Burisch, Johan, Creed, Tom, Demarzo, Maria Giulia, Festa, Stefano, Figueroa, Andrés, Julsgaard, Mette, Navarro, Pablo, Perez-Galindo, Pablo, Rouillon, Cléa, Sablich, Emanuele, Tosca, Joan, Vidon, Mathias, Vidon, Marine, Vitte, René-Louis, Wampach, Anne, Baumann, Cédric, Urmes, Isabelle Clerc, Rousseau, Hélène, Borie, Marc, Uzzan, Mathieu, Chatten, Kelly, Peter, Rimmer, Tariq, Iqbal, Cossignani, Marta, Cañete, Fiorella, Holvoet, Tom, Krasz, Susanne, Dias, Sandra, Abalia, Hadas, Abaza, Aziza, Abramovich, Gal, Ackzell, Ingrid, Adams, Carol, Addleton, Catherine, Alfambra, Erika, Algaba, Alicia, Allcock, Clare, Allison, Joanna, Amouriaux, Karine, Anderson, Julie, Anderson, Emma, Appelmans, Saskia, Armstrong, Lisa, Atkins, Stacey, Attaran-Bandarabadi, Masoumeh, Bailey, Yvonne, Bardot, Stephanie, Beck, Natasha, Bennett, Lillie, Bergfeld, Jonathan Phil, Berkane, Ramdane, Boey, Hanne, Bowlas, Louise, Bradley-Potts, Joanne, Brear, Tracy, Bretlander-Peters, Nicole, Brown, Ellen, Brown, Johanna, Buckingham, Elizabeth, Buellens, Katrien, Bull, Rhian, Burke, Maura, Burns, Leighanne, Burton, Julie, Bwalya, Agness, Cabanas, Karine, Callaghan, Muriel, Camou, Océane, Campbell, Debbie, Capoferro, Elvira, Carnahan, Mandy, Carnio, Cornelia, Carter, Anne, Clack, Concetta Casali, Chedouba, Leïla, Cipriano, Bessie, Claeys, Sophie, Closset, Manon, Coban, Dilek, Cococcia, Sara, Coe, Carolann, Cole, Helen, Collet, Emilie, Collins, Kayleigh, Combes, Isabelle, Connor, Emma, Constantin, Kathryn, Cooke, Susan, Cornet, Nathanaëlle, Corrihons, Estelle, Corsino, Pilar, Cortaville, Rosie, Cotterill, Donna, Cowton, Amanda, Cox, Harriet, Cripps, Viktoria, Crowder, Amanda, Cukier, Tzufit, Daniel, Amelia, Dawe, Chris, de Haan, Jose, Croix, Rosanna de la, Dejonckheere, Evva, Villanegro, Juan Delare, Delaval, Guillaume, Delliponti, Mariangela, Delommez, Aude, Detry, Emilie, Dhanaratne, Melanie, Galan, Laura Diez, Dodel, Marie, Dooks, Emma, Du Cheyron, Joseph, Duane, Linda, Vulgo Cochran, Jennifer Dulling, Dyer, Simona, Dymond, Harvey, Ekblad, Charlotte, Elliott, Kerry, Emmerson, Ingrid, Eugene-Jolchine, Irène, Fleming, Lorna, Fletcher, Eve, Ford, Sarah, Forshaw, Greg, Foulds, Angela, Francois, Caroline, Fuge, Nicole, Gafni, Gal, Ganon, Miri, Nuñez, Olga Garcia, Ramirez, Laura Garcia, Gelder, Sophie, Gettkowski, Raimonda, Gilardi, Daniela, Giuffrida, Paolo, Gobert, Vincent, Godden, Jo, Godwin, Nuala, Goulden, Kay, Graham, Sharon, Green, Charlotte, Green, Marie, Gueye, Aboubakar, Guler, Tuba, Gustavsson, Ida, Hadjisavvas, Helena, Hammonds, Fiona, Hantzi, Christina, Hauke, Marion, Haydock, Julie, Hayes, Orla, Nislev, Lizette Helbo, Hochstodter, Jessica, Hogg, Ashleigh, Hölbing, Manuela, Holland, Maureen, Holsbergen, Maartje, Howard, Linda, Hoyda, Aviya, Hull, Robert, Irish, Jane, Jackson, Wendy, Janssen, Wendy, Jeffrey, Lesley, Jourdan, Sofia, Jutrowska, Izabela, Kaniel, Chava, Karezos, Theofilos, Kelly, Niamh, Kelly, Jessica, Kennedy, Mary, Kennedy, Una, Kibaru, Joyce, Kirkman, Gemma, Klaproth, Janine, Kneese, Corinna, Koch, Andrea, Kokke, Kathleen, Koppelow, Martha, Krause, Sabine, Krauspe, Sabine, Kwakkenbos, Petra, Labarile, Nunzia, Lang, Hannah, Lassailly, Marianne, Leconte, Martine, Lepczynski, Linda, Levell, Emma, Levhar, Nina, Lindhort, Kerstin, Lisle, Jessica, Cauce, Beatriz Lopez, Lorenz, Gabriele, Lovati, Ambra, Lowry, Tracey, Lund, Margareta, Vorderbrügge, Anne Lutz, Maansson, Suzanne, Madapathage, Videsheka, Cheviakoff, Maelys, Magness, Alison, Manley, Orla, Manyoni, Catherine, Marg, Ingke, Marra, Antonella, Martins, Carole, Massella, Arianna, Mathias, Aurore, Mervyn, Danielle, Minsart, Charlotte, Mitchell, Sally, Monks, Kathleen, Montero, Mélanie, Moore, Alson, Moser, Maren, Moss, Alison, Mullen, Angela, Murciano, M. Francisca, Naylor, Deanna, Nehus, Ansgar, Nicholson, Anne, Nöding, Sarah, Nolan, Sinead, Nörenberg, Janet, Northcott, Clare, O'Connell, Jim, O’Kelly, Alison, Orbach-Zingboim, Noam, Orobitg, Judit, Otieno, Charlene, Owen, Charlotte, Patch, Sarah, Pauker, Maor, Pauli, Renate, Pearson, Harriet, Peggy, Falgon, Petit, Séverine, Petrissans, Christine, Piergallini, Simona, Pippard, Lucy, Pitt, Laura, Pócsik, Gabriella, Poher, Yoann, Pomes, Chloé, Pritchard, Lucy, Puchades, Laura, Quaid, Sheena, Rana, Aleem, Raynard, Dana, Reilly, Mykla, Reinert, Sonja, Reinknecht, Manuela, Renner, Baerbel, Reynolds, Rob, Rizzuto, Giulia, Robinson, Matthew, Robrechts, Joke, Rodriguez, Eva M., Rosenblum, Efrat, Russel, Tamlyn, Sadare, Ibiyemi, Salama, Noa, Schakel, Toos, Schauer, Anja, Schiavoni, Elisa, Shaw, Caroline, Shelton, Sarah, Sicart, Virginie, Siouville, Elodie, Smith, Orla, Soude, Théo, Stephenson, Sophie, Stephenson, Elaine, Steppe, Marjan, Sterkx, An, Stickley, Jo, Sugrue, Kathleen, Swietec, Natalia, Tasiaux, Charlotte, Thamu, Bhavneet, Thomas, Susane, Tobi, Ogwa, Touabi, Kahina, Tovi, Shifra, Tregonning, Julie, Turchini, Laura, Unkhoff, Julia, Unruh, Olesya, Uzun, Nurcan, Van Aert, Frauke, Bergh, Sandrine Vanden, Vandenbroucke, Louise, Vansteenkiste, Laura, Vardit, Shay, Vergriete, Valentin, Walker, Elaine, Warner, Eleanor, Watchorn, Olivia, Watson, Ekaterina, Wauthier, Marie-Claire, Weetman, Belgium Maria, Weston, Margaret, West-Petroschka, Wiebke, Wienecke, Susann, Wierling, Kerstin, Wiestler, Miriam, Wilcox, Rebecca, Wilhelmsen, Elva, Williams, Angharad, Williamson, Georgina, Wilson, Deborah, Wistance, Kate, Wortmann, Nicolas, Wurie, Subie, Yadgar, Karin, Young, Gail, Young, Megan, Aucouturier, Julien, Bertin, Marie- Jo, Bougrine, Hasnae, Coisnon, Marie, Defrance, Antoine, Gutierrez, Kati, Harouz, Amel, Jerber, Laure, Khlifi, Aida, Kirati, Amina, Liworo, Nasaladjine, Logoltat, Maude, Mailhat, Charlotte, M'Bayi, Chancely, Medane, Yasmina, Merkhoufa, Dalal, Elhad, Saouda Mohamed, Monthe, Bertille, Moyon, Fanny, Rabiega, Pascaline, Sekela, Jennifer, Thilloy, Charlotte, Hamamouche, Naima, Partisotti, Frederic, Blandin, Patrick, Mokhtari, Hocine, Coutard, Laure, and Doherty, Glen A.
- Published
- 2023
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3. Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study
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Abraham, Philip, Acir Crippa Júnior, Mauro, Aguilar, Humberto, Ahmed, Tasneem, Altorjay, Istvan, Andersen, Vibeke, Arai, Ronen, Arnold, Hays, Ausk, Karlee, Axler, Jeffrey, Ayub, Kamran, Balekuduru, Avinash, Barbalaco Neto, Guerino, Bassan, Isaac, Behm, Brian, Bekal, Pradeep, Bhatia, Shobna, Bod, Barnabas, Brandão Mello, Carlos Eduardo, Brandeburova, Julia, Breedt, Johannes, Bressler, Brian, Chopey, Ivan, Connor, Michael, Corlin, Richard, Cortez Hernandez, Carlos Alejandro, De, Arijit, de Sá Rolim, Alexander, Di Felice Boratto, Sandra, Dixon, Tyler, Dourado Poli, Debora, Dresner, David, Du Vall, George Aaron, Ebert, Matthias, Ehehalt, Robert, Ertan, Atilla, Escarcega Valencia, Ruben, Etzel, Jason, Fallingborg, Jan, Feagan, Brian, Fedurco, Miroslav, Fernandez Castro, Enrique, Ferreira de Almeida Borges, Valéria, Finklestein, Mark, Fischer, Andreas, Fleisher, Mark, Flores Rendon, Angel Ricardo, Fogel, Ronald, Franceschi Junior, Osvaldo, Freedland, Curtis, Gatof, David, Gill, Kanwar, Glerup, Henning, Gokak, Vardaraj, Goldin, Eran, Gomez Jaramillo, Hector Alejandro, Gupta, Nitin, Gurzo, Zoltan, Gyrina, Olga, Habeeb, Mohammed Aejaz, Hanauer, Stephen, Hardi, Robert, Harlan, William, Hemaidan, Ammar, Heyman, Melvin, Hoffmann, Peter, Holderman, William, Holtkamp-Endemann, Frank, Horvat, Gyula, Isaacs, Kim, Israeli, Eran, Jankiel Miszputen, Sender, Jensen, Søren, Johnson, Kenneth, Jones, Jennifer, Junior, Osvaldo, Kadleckova, Barbora, Kalla, Mukesh, Kallo, Zsuzsanna, Karyotakis, Nicholas, Katz, Lior, Katz, Leo, Kaur, Nirmal, Khanna, Reena, Kohout, Pavel, Lakatos, Peter, Larriva de los Reyes, Emmanuel, Lee, Robert, Leman, Bernard, Levchenko, Olena, Levine, Henry, Libanez Bessa Campelo Braga, Lúcia, Loftus, Edward, Lohdanidi, Tetiana, Longman, Randy, Lozano, Josefina, Maaser, Christian, Madi-Szabo, Laszlo, Malluta, Everson Fernando, Marshall, John, Martinez Silva, Francisca, Maynard, Kenneth, Meder, Agnieszka, Mehta, Chetan, Minarik, Peter, Mueller, Joachim, Mukewar, Shrikant, Nagy, Bela, Neiko, Vasyl, Neurath, Markus, Nichol, Brian, Novick, James, Pai, Nitin, Pandak, William, Panigrahi, Sarat, Pape, Ulrich-Frank, Paraná, Raymundo, Parekh, Nimisha, Patel, Bhaktasharan, Pecsi, Gyula, Peralta, Sergio, Pesta, Martin, Peterfai, Eva, Petruzzellis, Carlo, Petryka, Robert, Pica, Roberta, Piniella, Carlos, Pratha, Vijayalakshmi, Prochazka, Vlastimil, Prokopchuk, Sergey, Prystupa, Ludmyla, Puri, Amarender, Rainis, Tova, Ramesh Kumar, Bhashyakarla, Ramos Júnior, Odery, Rishko, Iaroslava, Ritter, Timothy, Robbins, Bryan, Rock, Elizabeth, Rodrigues Borba, Marcelo, Rodriguez, Miguel, Rozciecha, Jerzy, Ruiz Flores, Azalia Yuriria, Rydzewska, Grazyna, Safadi, Rifaat, Saibeni, Simone, Schirbel, Anja, Schmiegel, Wolff, Schnabel, Róbert, Schneider, Herbert, Segui, Armando, Seidelin, Jakob, Seidler, Ursula, Sellin, Joseph, Shafran, Ira, Shah, Saumin, Sheikh, Aasim, Sherman, Alex, Shirin, Haim, Shukla, Akash, Siddiqui, Firdous, Sike, Robert, Sood, Ajit, Stallmach, Andreas, Stanislavchuk, Mykola, Staun, Michael, Stein, Daniel, Steinberg, Alon, Steinhart, Hillary, Stifft, Jonathas, Tandon, Rakesh, Tantry, Vishwanath, Thiwan, Syed, Treiber, Matthias, Ulbrych, Jan, Valentine, John, Vasudeva, Rajeev, Vaughn, Byron, Velasco, Brenda, Vincze, Aron, Volfova, Miroslava, Waterman, Mattitiahu, Weiss, L. Michael, Wiesner, Elise, Williams, Alonzo, Witthoeft, Thomas, Wohlman, Robert, Wright, John, Yamamoto Furusho, Jesus Kazuo, Younes, Ziad, Yousuf, Khurshid, Zborivskyy, Yaroslav, Zeuzem, Stefan, Zhdan, Vyacheslav, Vermeire, Severine, Lakatos, Peter L, Kadva, Alysha, Tyrrell, Helen, Oh, Young S, Tole, Swati, Chai, Akiko, Pulley, Jennifer, Eden, Christopher, Zhang, Wenhui, and Feagan, Brian G
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- 2022
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4. Enteropathic spondyloarthritis: Results from a large nationwide database analysis
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Zullo, Angelo, Caso, Francesco, Costa, Luisa, Tomietto, Paola, Fabio, Fischetti, Scolieri, Palma, Navarini, Luca, Cuccagna, Elisa, Severino Martin-Martin, Luis, Lia Scribano, Maria, Faggiani, Roberto, Pagnini, Cristiano, Mocci, Giammarco, Demurtas, Mauro, Tursi, Antonio, Festa, Stefano, Zerboni, Giulia, Pica, Roberta, Ridola, Lorenzo, Paroli, Marino, Baccini, Flavia, Baincone, Livia, Gabrielli, Armando, Afeltra, Antonella, Scarpa, Raffaele, Picchianti-Diamanti, Andrea, Lorenzetti, Roberto, Chimenti, Maria Sole, Luchetti, Michele Maria, Conigliaro, Paola, Canofari, Claudia, Benfaremo, Devis, Bruzzese, Vincenzo, Laganà, Bruno, and Perricone, Roberto
- Published
- 2020
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5. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study
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Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
- Abstract
BackgroundUstekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients with UC in a real-world setting.Research design and methodsThis is a multicenter, retrospective, observational cohort study. The primary endpoints were the clinical remission rate (partial Mayo score, PMS, <= 1) and the safety of UST. Other endpoints were corticosteroid-free remission (CSFR) rate, clinical response rate (PMS reduction of at least 2 points), and fecal calprotectin (FC) reduction at week 24.ResultsWe included 256 consecutive patients with UC (M/F 139/117, median age 52). The clinical remission and clinical response rates at eight weeks were 18.7% (44/235) and 53.2% (125/235), respectively, and 27.6% (42/152) and 61.8% (94/152) at 24 weeks, respectively. At 24 weeks, CSFR was 20.3% (31/152), and FC significantly dropped at week 12 (p = 0.0004) and 24 (p = 0.038). At eight weeks, patients naive or with one previous biologic treatment showed higher remission (p = 0.002) and clinical response rates (p = 0.018) than patients previously treated with >= 2. Adverse events occurred in six patients (2.3%), whereas four patients (1.6%) underwent colectomy.ConclusionThis real-world study shows that UST effectively and safely treats patients with UC.
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- 2024
6. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Leone, Salvatore, Previtali, Enrica, Aloi, Marina, Alvisi, Patrizia, Antonelli, Elisabetta, Ardizzone, Sandro, Astegiano, Marco, Baldoni, Monia, Beltrami, Marina, Biancone, Livia, Bodini, Giorgia, Buda, Andrea, Bossa, Fabrizio, Bracci, Fiammetta, Calabrese, Emma, Cappello, Maria, Castiglione, Fabiana, Ciacci, Carolina, Cicala, Michele, Ciccocioppo, Rachele, Comberlato, Michele, Cortelezzi, Claudio Camillo, Cosintino, Rocco, Costa, Francesco, Costantino, Giuseppe, Cucchiara, Salvatore, Cuomo, Antonio, D’Incà, Renata, Di Paolo, Maria Carla, Di Sabatino, Antonio, Di Sario, Antonio, Frieri, Giuseppe, Fries, Walter, Gasbarrini, Antonio, Geccherle, Andrea, Gionchetti, Paolo, Graziani, Maria Giovanna, Grossi, Laurino, Guidi, Luisa, Imperiali, Gianni, Latella, Giovanni, Lionetti, Paolo, Inserra, Gaetano, Maconi, Giovanni, Manguso, Francesco, Marino, Marco, Mastronardi, Mauro, Mazzuoli, Silvia, Meucci, Gianmichele, Mendolaro, Marco, Milla, Monica, Mocci, Giammarco, Monteleone, Giovanni, Bortoluzzi, Francesco Neri, Pagnini, Cristiano, Pastorelli, Luca, Pica, Roberta, Piergallini, Simona, Privitera, Antonello, Renna, Sara, Ribaldone, Davide Giuseppe, Ricci, Chiara, Rispo, Antonio, Rocca, Rodolfo, Romano, Claudio, Romano, Marco, Russo, Giovanni, Sablich, Renato, Saibeni, Simone, Savarino, Edoardo, Scribano, Maria Lia, Spagnuolo, Rocco, Stasi, Elisa, Terpin, Maria Maddalena, Testa, Anna, Valpiani, Daniela, Variola, Angela, Vernia, Piero, Vitale, Giovanna, Zoli, Giorgio, Fiorino, Gionata, Caprioli, Flavio, Daperno, Marco, Mocciaro, Filippo, Principi, Mariabeatrice, Viscido, Angelo, Fantini, Massimo Claudio, Orlando, Ambrogio, Papi, Claudio, Annese, Vito, Danese, Silvio, Vecchi, Maurizio, Rizzello, Fernando, and Armuzzi, Alessandro
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- 2019
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7. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study
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Tursi, Antonio, primary, Mocci, Giammarco, additional, Scaldaferri, Franco, additional, Napolitano, Daniele, additional, Maresca, Rossella, additional, Pugliese, Daniela, additional, Semprucci, Gianluca, additional, Savarino, Edoardo, additional, Cuomo, Antonio, additional, Donnarumma, Laura, additional, Bodini, Giorgia, additional, Pasta, Andrea, additional, Maconi, Giovanni, additional, Cataletti, Giovanni, additional, Pranzo, Giuseppe, additional, Rodinò, Stefano, additional, Sebkova, Ladislava, additional, Costa, Francesco, additional, Ferronato, Antonio, additional, Gaiani, Federica, additional, Marzo, Manuela, additional, Luppino, Ileana, additional, Fabiano, Giulia, additional, Paese, Pietro, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Grossi, Laurino, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Chiri, Stefania, additional, Grasso, Giuseppina, additional, Antonelli, Elisabetta, additional, Bassotti, Gabrio, additional, Spagnuolo, Rocco, additional, Luzza, Francesco, additional, Fanigliulo, Libera, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Rocchi, Chiara, additional, Bolognini, Laura, additional, Bendia, Emanuele, additional, Bianco, Maria Antonia, additional, Capone, Pietro, additional, Meucci, Costantino, additional, Colucci, Raffaele, additional, Tonti, Paolo, additional, Neve, Viviana, additional, Della Valle, Nicola, additional, Felice, Carla, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Forti, Giacomo, additional, Onidi, Francesca Maria, additional, Usai Satta, Paolo, additional, Checchin, Davide, additional, Gravina, Antonietta Gerarda, additional, Pellegrino, Raffaele, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional
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- 2024
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8. Safety of treatments for inflammatory bowel disease: Clinical practice guidelines of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Aratari, Annalisa, Bossa, Fabrizio, Cappello, Maria, Cassinotti, Andrea, Chiriatti, Alberto, Fiorino, Gionata, Formica, Vincenzo, Guidi, Luisa, Losco, Alessandra, Mocciaro, Filippo, Onali, Sara, Pastorelli, Luca, Pica, Roberta, Principi, Mariabeatrice, Renna, Sara, Ricci, Chiara, Rispo, Antonio, Rogai, Francesca, Sarmati, Loredana, Scaldaferri, Franco, Spina, Luisa, Tambasco, Rosy, Testa, Anna, Viscido, Angelo, Biancone, Livia, Annese, Vito, Ardizzone, Sandro, Armuzzi, Alessandro, Calabrese, Emma, Caprioli, Flavio, Castiglione, Fabiana, Comberlato, Michele, Cottone, Mario, Danese, Silvio, Daperno, Marco, D’Incà, Renata, Frieri, Giuseppe, Fries, Walter, Gionchetti, Paolo, Kohn, Anna, Latella, Giovanni, Milla, Monica, Orlando, Ambrogio, Papi, Claudio, Petruzziello, Carmelina, Riegler, Gabriele, Rizzello, Fernando, Saibeni, Simone, Scribano, Maria Lia, Vecchi, Maurizio, Vernia, Piero, and Meucci, Gianmichele
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- 2017
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9. Use of tofacitinib as first or second-line therapy is associated with better outcomes in patients with ulcerative colitis: data from a real-world study
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Tursi, Antonio, primary, Mocci, Giammarco, additional, Cingolani, Linda, additional, Savarino, Edoardo, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Zippi, Maddalena, additional, Napolitano, Daniele, additional, Schiavoni, Elisa, additional, Pugliese, Daniela, additional, Scaldaferri, Franco, additional, Costa, Francesco, additional, Marzo, Manuela, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Bolognini, Laura, additional, Bendia, Emanuele, additional, Maconi, Giovanni, additional, Cannatelli, Rosanna, additional, Piergallini, Simona, additional, Bodini, Giorgia, additional, Calabrese, Francesco, additional, Ferronato, Antonio, additional, Pranzo, Giuseppe, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Rodinò, Stefano, additional, Sebkova, Ladislava, additional, Grossi, Laurino, additional, Gaiani, Federica, additional, dè Angelis, Gianluigi, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Cazzato, Alessia Immacolata, additional, Scorza, Stefano, additional, Della Valle, Nicola, additional, Sacco, Rodolfo, additional, Forti, Giacomo, additional, Colucci, Raffaele, additional, Tonti, Paolo, additional, Neve, Viviana, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Pagnini, Cristiano, additional, Graziani, Maria Giovanna, additional, Di Paolo, Maria Carla, additional, Onidi, Francesca Maria, additional, Usai Satta, Paolo, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional
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- 2023
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10. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn's disease: results from an Italian multicenter study
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Mocci, Giammarco, Tursi, Antonio, Maconi, Giovanni, Cataletti, Giovanni, Mantia, Beatrice, Serio, Mariaelena, Scarcelli, Antonella, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Pranzo, Giuseppe, Luppino, Ileana, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Ferronato, Antonio, Perini, Barbara, Savarino, Edoardo, Onidi, Francesca Maria, Binaghi, Laura, Usai Satta, Paolo, Schiavoni, Elisa, Napolitano, Daniele, Scaldaferri, Franco, Pugliese, Daniela, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Rodino, Stefano, Sebkova, Ladislava, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Gaiani, Federica, De Angelis, Gianluigi, Kayali, Stefano, Fanigliulo, Libera, Lorenzetti, Roberto, Allegretta, Leonardo, Scorza, Stefano, Cuomo, Antonio, Donnarumma, Laura, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Antonelli, Elisabetta, Bassotti, Gabrio, Iannelli, Chiara, Luzza, Francesco, Aragona, Giovanni, Perazzo, Patrizia, Lauria, Angelo, Piergallini, Simona, Colucci, Raffaele, Bianco, Maria Antonia, Meucci, Costantino, Giorgetti, Gianmarco, Clemente, Valeria, Fiorella, Serafina, Penna, Antonio, De Medici, Antonio, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Mocci, Giammarco, Tursi, Antonio, Maconi, Giovanni, Cataletti, Giovanni, Mantia, Beatrice, Serio, Mariaelena, Scarcelli, Antonella, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Pranzo, Giuseppe, Luppino, Ileana, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Ferronato, Antonio, Perini, Barbara, Savarino, Edoardo, Onidi, Francesca Maria, Binaghi, Laura, Usai Satta, Paolo, Schiavoni, Elisa, Napolitano, Daniele, Scaldaferri, Franco, Pugliese, Daniela, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Rodino, Stefano, Sebkova, Ladislava, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Gaiani, Federica, De Angelis, Gianluigi, Kayali, Stefano, Fanigliulo, Libera, Lorenzetti, Roberto, Allegretta, Leonardo, Scorza, Stefano, Cuomo, Antonio, Donnarumma, Laura, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Antonelli, Elisabetta, Bassotti, Gabrio, Iannelli, Chiara, Luzza, Francesco, Aragona, Giovanni, Perazzo, Patrizia, Lauria, Angelo, Piergallini, Simona, Colucci, Raffaele, Bianco, Maria Antonia, Meucci, Costantino, Giorgetti, Gianmarco, Clemente, Valeria, Fiorella, Serafina, Penna, Antonio, De Medici, Antonio, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
- Abstract
BackgroundVedolizumab (VDZ) can be used to treat refractory ulcerative colitis (UC) and Crohn's disease (CD). We assessed whether there are differences in treating UC vs CD with VDZ.Research design and methods Mayo score in UC and the Harvey-Bradshaw Index (HBI) in CD scored the clinical activity. Achievement and maintenance of clinical remission during the follow-up, and safety were the primary endpoints.Results729 patients (475 with UC and 254 with CD), median follow-up of 18 (IQR 6-36) months, were enrolled. Clinical remission at the 6(th) month of treatment was achieved in 488 (66.9%) patients (74.4% in CD vs 62.9% in UC, p<0.002) while, during the follow-up, no difference was found (81.5% in the UC group and 81.5% pts in the CD group; p=0.537). The clinical remission at the 6(th) month of treatment (p=0.001) and being naive to biologics (p<0.0001) were significantly associated with prolonged clinical remission. The clinical response was significantly higher in UC (90.1%) vs CD (84.3%) (p=0.023), and surgery occurred more frequently in CD (1.9% in UC vs 5.1% in CD, p=0.016).ConclusionWe found differences when using VDZ in UC vs CD in real life. These parameters can help the physician predict this drug's longterm efficacy.
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- 2023
11. Comparison of Performances of Adalimumab Biosimilars SB5, ABP501, GP2017, and MSB11022 in Treating Patients with Inflammatory Bowel Diseases: A Real-Life, Multicenter, Observational Study
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Tursi, Antonio, Mocci, Giammarco, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Cuomo, Antonio, Della Valle, Nicola, Ferronato, Antonio, Forti, Giacomo, Gaiani, Federica, Giorgetti, Gianmarco, Graziani, Maria Giovanna, Lofano, Katia, Lorenzetti, Roberto, Larussa, Tiziana, Penna, Antonio, Pica, Roberta, Pranzo, Giuseppe, Rodino', Stefano, Scarcelli, Antonella, Zampaletta, Costantino, Bassotti, Gabrio, Cazzato, Alessia Immacolata, Chiri, Stefania, Clemente, Valeria, Cocco, Andrea, De' Angelis, Gianluigi, Donnarumma, Laura, Faggiani, Roberto, Graziosi, Camilla, Le Grazie, Marco, Luzza, Francesco, Meucci, Costantino, Monterubbianesi, Rita, Pagnini, Cristiano, Perazzo, Patrizia, Picchio, Marcello, Sacco, Rodolfo, Sebkova, Ladislava, Serio, Mariaelena, Napolitano, Daniele, Pugliese, Daniela, Scaldaferri, Franco, Schiavoni, Elisa, Turchini, Laura, Armuzzi, Alessandro, Elisei, Walter, Maconi, Giovanni, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Cuomo, Antonio, Della Valle, Nicola, Ferronato, Antonio, Forti, Giacomo, Gaiani, Federica, Giorgetti, Gianmarco, Graziani, Maria Giovanna, Lofano, Katia, Lorenzetti, Roberto, Larussa, Tiziana, Penna, Antonio, Pica, Roberta, Pranzo, Giuseppe, Rodino', Stefano, Scarcelli, Antonella, Zampaletta, Costantino, Bassotti, Gabrio, Cazzato, Alessia Immacolata, Chiri, Stefania, Clemente, Valeria, Cocco, Andrea, De' Angelis, Gianluigi, Donnarumma, Laura, Faggiani, Roberto, Graziosi, Camilla, Le Grazie, Marco, Luzza, Francesco, Meucci, Costantino, Monterubbianesi, Rita, Pagnini, Cristiano, Perazzo, Patrizia, Picchio, Marcello, Sacco, Rodolfo, Sebkova, Ladislava, Serio, Mariaelena, Napolitano, Daniele, Pugliese, Daniela, Scaldaferri, Franco, Schiavoni, Elisa, Turchini, Laura, Armuzzi, Alessandro, Elisei, Walter, Maconi, Giovanni, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
- Abstract
Background Adalimumab (ADA) biosimilars have entered the therapeutic armamentarium of inflammatory bowel disease (IBD), allowing for the treatment of a greater number of patients for their reduced cost than the originator. However, comparative data on the efficacy and safety of the various ADA biosimilars remains scarce. We compare the efficacy and safety of ADA biosimilars SB5, APB501, GP2017, and MSB11022 in treating IBD outpatients in a real-life Italian setting. Methods A retrospective analysis was performed on consecutive IBD outpatients with complete clinical, laboratory, and endoscopic data. Clinical activity was measured using the Mayo score in ulcerative colitis (UC) and the Harvey-Bradshaw Index in Crohn's disease (CD). The primary endpoints were the following: (1) induction of remission in patients new to biologics and patients new to ADA but previously exposed to other anti-tumor necrosis factor agents or other biologics; (2) maintenance of remission in patients switched from the ADA originator to an ADA biosimilar; and (3) safety of various biosimilars. Results A total of 533 patients were enrolled according to the inclusion criteria: 162 patients with UC and 371 patients with CD. Clinical remission was obtained in 79.6% of patients new to biologics and 59.2% of patients new to ADA but not to other biologics; clinical remission was maintained in 81.0% of patients switched from the originator, and adverse events were recorded in 6.7% of patients. There was no significant difference between the 4 ADA biosimilars for each predetermined endpoint. Conclusions Adalimumab biosimilars are effective and safe in IBD treatment, both in new patients and in patients switched from the ADA originator. No difference in efficacy and safety was found between ADA biosimilars.Lay Summary We treated 533 IBD patients with adalimumab (ADA) biosimilars SB5, APB501, GP2017, and MSB11022. No differences between these 4 ADA biosimilars were found for reaching remission in naive p
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- 2023
12. Use of tofacitinib as first or second-line therapy is associated with better outcomes in patients with ulcerative colitis: data from a real-world study
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Tursi, Antonio, Mocci, Giammarco, Cingolani, Linda, Savarino, Edoardo, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Napolitano, Daniele, Schiavoni, Elisa, Pugliese, Daniela, Scaldaferri, Franco, Costa, Francesco, Marzo, Manuela, Serio, Mariaelena, Scarcelli, Antonella, Bolognini, Laura, Bendia, Emanuele, Maconi, Giovanni, Cannatelli, Rosanna, Piergallini, Simona, Bodini, Giorgia, Calabrese, Francesco, Ferronato, Antonio, Pranzo, Giuseppe, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Rodinò, Stefano, Sebkova, Ladislava, Grossi, Laurino, Gaiani, Federica, dè Angelis, Gianluigi, Lorenzetti, Roberto, Allegretta, Leonardo, Cazzato, Alessia Immacolata, Scorza, Stefano, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Onidi, Francesca Maria, Usai Satta, Paolo, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Cingolani, Linda, Savarino, Edoardo, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Napolitano, Daniele, Schiavoni, Elisa, Pugliese, Daniela, Scaldaferri, Franco, Costa, Francesco, Marzo, Manuela, Serio, Mariaelena, Scarcelli, Antonella, Bolognini, Laura, Bendia, Emanuele, Maconi, Giovanni, Cannatelli, Rosanna, Piergallini, Simona, Bodini, Giorgia, Calabrese, Francesco, Ferronato, Antonio, Pranzo, Giuseppe, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Rodinò, Stefano, Sebkova, Ladislava, Grossi, Laurino, Gaiani, Federica, dè Angelis, Gianluigi, Lorenzetti, Roberto, Allegretta, Leonardo, Cazzato, Alessia Immacolata, Scorza, Stefano, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Onidi, Francesca Maria, Usai Satta, Paolo, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
- Abstract
BackgroundData regarding the real-world (RW) use of tofacitinib (TOF) in patients with ulcerative colitis (UC) are limited. We aimed to investigate TOF's RW efficacy and safety in Italian UC patients.Research design and methodsA retrospective assessment of clinical and endoscopic activity was performed according to the Mayo score. The primary endpoints were to evaluate the effectiveness and safety of TOF.ResultsWe enrolled 166 patients with a median follow-up of 24 (IQR 8-36) weeks. Clinical remission was achieved in 61/166 (36.7%) and 75/166 (45.2%) patients at 8-week and 24-week follow-ups, respectively. The optimization was requested in 27 (16.3%) patients. Clinical remission was achieved more frequently when TOF was used as a first/second line rather than a third/fourth line treatment (p = 0.007). Mucosal healing was reported in 46% of patients at the median follow-up time. Colectomy occurred in 8 (4.8%) patients. Adverse events occurred in 12 (5.4%) patients and severe in 3 (1.8%). One case of simple Herpes Zoster and one of renal vein thrombosis were recorded.ConclusionsOur RW data confirm that TOF is effective and safe in UC patients. It performs remarkably better when used as the first/second line of treatment.
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- 2023
13. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn’s disease: results from an Italian multicenter study
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Mocci, Giammarco, primary, Tursi, Antonio, additional, Maconi, Giovanni, additional, Cataletti, Giovanni, additional, Mantia, Beatrice, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Pagnini, Cristiano, additional, Graziani, Maria Giovanna, additional, Di Paolo, Maria Carla, additional, Pranzo, Giuseppe, additional, Luppino, Ileana, additional, Paese, Pietro, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Ferronato, Antonio, additional, Perini, Barbara, additional, Savarino, Edoardo, additional, Onidi, Francesca Maria, additional, Binaghi, Laura, additional, Usai Satta, Paolo, additional, Schiavoni, Elisa, additional, Napolitano, Daniele, additional, Scaldaferri, Franco, additional, Pugliese, Daniela, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Zippi, Maddalena, additional, Rodino, Stefano, additional, Sebkova, Ladislava, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Gaiani, Federica, additional, De Angelis, Gianluigi, additional, Kayali, Stefano, additional, Fanigliulo, Libera, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Scorza, Stefano, additional, Cuomo, Antonio, additional, Donnarumma, Laura, additional, Della Valle, Nicola, additional, Sacco, Rodolfo, additional, Forti, Giacomo, additional, Antonelli, Elisabetta, additional, Bassotti, Gabrio, additional, Iannelli, Chiara, additional, Luzza, Francesco, additional, Aragona, Giovanni, additional, Perazzo, Patrizia, additional, Lauria, Angelo, additional, Piergallini, Simona, additional, Colucci, Raffaele, additional, Bianco, Maria Antonia, additional, Meucci, Costantino, additional, Giorgetti, Gianmarco, additional, Clemente, Valeria, additional, Fiorella, Serafina, additional, Penna, Antonio, additional, De Medici, Antonio, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional
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- 2023
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14. Antibiotic-Loaded Coatings to Reduce Fracture-Related Infections: Retrospective Case Series of Patients with Increased Infectious Risk
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De Meo, Daniele, primary, Cera, Gianluca, additional, Pica, Roberta, additional, Perfetti, Fabiano, additional, Martini, Paolo, additional, Perciballi, Beatrice, additional, Ceccarelli, Giancarlo, additional, Persiani, Pietro, additional, and Villani, Ciro, additional
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- 2023
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15. A randomized trial comparing 4.8 vs. 2.4 g/day of oral mesalazine for maintenance of remission in ulcerative colitis
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Pica, Roberta, Cassieri, Claudio, Cocco, Andrea, Zippi, Maddalena, Marcheggiano, Adriana, De Nitto, Daniela, Avallone, Eleonora Veronica, Crispino, Pietro, Occhigrossi, Giuseppe, and Paoluzi, Paolo
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- 2015
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16. Replacement of Adalimumab Originator to Adalimumab Biosimilar for a Non-Medical Reason in Patients with Inflammatory Bowel Disease: A Real-life Comparison of Adalimumab Biosimilars Currently Available in Italy
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Tursi, Antonio, primary, Mocci, Giammarco, primary, Cuomo, Antonio, primary, Ferronato, Antonio, primary, Elisei, Walter, primary, Picchio, Marcello, primary, Maconi, Giovanni, primary, Scaldaferri, Franco, primary, Papa, Alfredo, primary, Italian group for switch of biologics, -, primary, Allegretta, Leonardo, primary, Aragona, Giovanni, primary, Bianco, Maria Antonia, primary, Colucci, Raffaele, primary, Della Valle, Nicola, primary, Faggiani, Roberto, primary, Forti, Giacomo, primary, Gaiani, Federica, primary, Giorgetti, GianMarco, primary, Graziani, Maria Giovanna, primary, Lofano, Katia, primary, Lorenzetti, Roberto, primary, Larussa, Tiziana, primary, Penna, Antonio, primary, Bassotti, Gabrio, primary, Cazzato, Alessia Immacolata, primary, Chiri, Stefania, primary, Clemente, Valeria, primary, Cocco, Andrea, primary, De’ Angelis, Gianluigi, primary, Donnarumma, Laura, primary, Graziosi, Camilla, primary, Le Grazie, Marco, primary, Luzza, Francesco, primary, Meucci, Costantino, primary, Monterubbianesi, Rita, primary, Pagnini, Cristiano, primary, Perazzo, Patrizia, primary, Pica, Roberta, primary, Pranzo, Giuseppe, primary, Rodino’, Stefano, primary, Sacco, Rodolfo, primary, Sebkova, Ladislava, primary, Scarcelli, Antonella, primary, Serio, Mariaelena, primary, Napolitano, Daniele, primary, Pugliese, Daniela, primary, Schiavoni, Elisa, primary, Turchini, Laura, primary, Armuzzi, Alessandro, primary, and Zampaletta, Costantino, primary
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- 2022
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17. Inter-observer agreement in endoscopic scoring systems: Preliminary report of an ongoing study from the Italian Group for Inflammatory Bowel Disease (IG-IBD)
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Daperno, Marco, Comberlato, Michele, Bossa, Fabrizio, Biancone, Livia, Bonanomi, Andrea G., Cassinotti, Andrea, Cosintino, Rocco, Lombardi, Giovanni, Mangiarotti, Roberto, Papa, Alfredo, Pica, Roberta, Rizzello, Fernando, D’Incà, Renata, and Orlando, Ambrogio
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- 2014
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18. Treatment of Unstable Elbow Injuries with a Hinged Elbow Fixator: Subjective and Objective Results
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Eygendaal, Denise, primary, Mader, Konrad, additional, Rollo, Giuseppe, additional, Prkic, Ante, additional, Meccariello, Luigi, additional, Caiaffa, Vincenzo, additional, Bisaccia, Michele, additional, Pica, Giuseppe, additional, Utrilla-Hernando, Sonia, additional, and Pica, Roberta, additional
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- 2022
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19. Comparison of Performances of Adalimumab Biosimilars SB5, ABP501, GP2017, and MSB11022 in Treating Patients with Inflammatory Bowel Diseases: A Real-Life, Multicenter, Observational Study
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Tursi, Antonio, primary, Mocci, Giammarco, additional, Allegretta, Leonardo, additional, Aragona, Giovanni, additional, Bianco, Maria Antonia, additional, Colucci, Raffaele, additional, Cuomo, Antonio, additional, Della Valle, Nicola, additional, Ferronato, Antonio, additional, Forti, Giacomo, additional, Gaiani, Federica, additional, Giorgetti, GianMarco, additional, Graziani, Maria Giovanna, additional, Lofano, Katia, additional, Lorenzetti, Roberto, additional, Larussa, Tiziana, additional, Penna, Antonio, additional, Pica, Roberta, additional, Pranzo, Giuseppe, additional, Rodino’, Stefano, additional, Scarcelli, Antonella, additional, Zampaletta, Costantino, additional, Bassotti, Gabrio, additional, Cazzato, Alessia Immacolata, additional, Chiri, Stefania, additional, Clemente, Valeria, additional, Cocco, Andrea, additional, de’ Angelis, Gianluigi, additional, Donnarumma, Laura, additional, Faggiani, Roberto, additional, Graziosi, Camilla, additional, Le Grazie, Marco, additional, Luzza, Francesco, additional, Meucci, Costantino, additional, Monterubbianesi, Rita, additional, Pagnini, Cristiano, additional, Perazzo, Patrizia, additional, Picchio, Marcello, additional, Sacco, Rodolfo, additional, Sebkova, Ladislava, additional, Serio, Mariaelena, additional, Napolitano, Daniele, additional, Pugliese, Daniela, additional, Scaldaferri, Franco, additional, Schiavoni, Elisa, additional, Turchini, Laura, additional, Armuzzi, Alessandro, additional, Elisei, Walter, additional, Maconi, Giovanni, additional, and Papa, Alfredo, additional
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- 2022
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20. Treatment of Unstable Elbow Injuries with a Hinged Elbow Fixator:Subjective and Objective Results
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Meccariello, Luigi, Caiaffa, Vincenzo, Mader, Konrad, Prkic, Ante, Eygendaal, Denise, Bisaccia, Michele, Pica, Giuseppe, Utrilla-Hernando, Sonia, Pica, Roberta, Rollo, Giuseppe, Meccariello, Luigi, Caiaffa, Vincenzo, Mader, Konrad, Prkic, Ante, Eygendaal, Denise, Bisaccia, Michele, Pica, Giuseppe, Utrilla-Hernando, Sonia, Pica, Roberta, and Rollo, Giuseppe
- Abstract
Introduction: Injuries around the elbow pose a challenging problem for orthopaedic surgeons. The complex bony architecture of the joint should be restored and the thin soft tissue envelope needs to be handled with meticulous care. Elbow instability is a complication seen after dislocations and fractures of the elbow and remains a treatment challenge. The purpose of this study was to provide subjective and objective results following the surgical treatment of unstable elbow dislocations with an external hinged fixation technique. Methods: Forty-six consecutive patients with complex trauma of the elbow with instability after ligament reconstruction were enrolled between January 2017 and December 2019. The parameters used to quantify the subjective and objective functional results were the Mayo Elbow Score (MES, objective) and Oxford Elbow Score (OES, subjective), and clinical stability of the elbow joint. We also performed a radiological follow-up of the fractures. Results: The mean MES and OES scores were good at the 12-month follow-up. We had 38 patients with stable joints and 8 patients with minor instability. Using the stress test, we saw a significant difference in the affected joint under varus stress (6.7 ± 1.8 mm) compared to the healthy joint (5.8 ± 1.2 mm) laterally. Furthermore, medially the gap was significantly larger (5.8 ± 0.8 mm, treated elbow) than the contralateral gap under valgus stress (4.3 ± 0.8 mm) (p <0.001). Twenty-one complications occurred in 46 patients (46%): Seven patients had a clinical change of elbow axis: Three valgus (6%), four varus (9%); Superficial wound infection occurred in one case (2%) and ulnar nerve dysfunction in two (4%). The most common medium-term complication was post-traumatic osteoarthritis in eight cases (17%). Heterotopic ossification occurred in five patients (11%) and elbow stiffness in five cases (11%). Conclusion: The use of the hinged elbow external fixator in the treatment of complex elbow trauma is a va
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- 2022
21. Replacement of Adalimumab Originator to Adalimumab Biosimilar for a Non-Medical Reason in Patients with Inflammatory Bowel Disease: A Real-life Comparison of Adalimumab Biosimilars Currently Available in Italy
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Tursi, Antonio, Mocci, Giammarco, Cuomo, Antonio, Ferronato, Antonio, Elisei, Walter, Picchio, Marcello, Maconi, Giovanni, Scaldaferri, Franco, Papa, Alfredo, Italian group for switch of biologics,, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Della Valle, Nicola, Faggiani, Roberto, Forti, Giacomo, Gaiani, Federica, Giorgetti, Gianmarco, Graziani, Maria Giovanna, Lofano, Katia, Lorenzetti, Roberto, Larussa, Tiziana, Penna, Antonio, Bassotti, Gabrio, Cazzato, Alessia Immacolata, Chiri, Stefania, Clemente, Valeria, Cocco, Andrea, De’ Angelis, Gianluigi, Donnarumma, Laura, Graziosi, Camilla, Le Grazie, Marco, Luzza, Francesco, Meucci, Costantino, Monterubbianesi, Rita, Pagnini, Cristiano, Perazzo, Patrizia, Pica, Roberta, Pranzo, Giuseppe, Rodino’, Stefano, Sacco, Rodolfo, Sebkova, Ladislava, Scarcelli, Antonella, Serio, Mariaelena, Napolitano, Daniele, Pugliese, Daniela, Schiavoni, Elisa, Turchini, Laura, Armuzzi, Alessandro, Zampaletta, Costantino, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Cuomo, Antonio, Ferronato, Antonio, Elisei, Walter, Picchio, Marcello, Maconi, Giovanni, Scaldaferri, Franco, Papa, Alfredo, Italian group for switch of biologics,, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Della Valle, Nicola, Faggiani, Roberto, Forti, Giacomo, Gaiani, Federica, Giorgetti, Gianmarco, Graziani, Maria Giovanna, Lofano, Katia, Lorenzetti, Roberto, Larussa, Tiziana, Penna, Antonio, Bassotti, Gabrio, Cazzato, Alessia Immacolata, Chiri, Stefania, Clemente, Valeria, Cocco, Andrea, De’ Angelis, Gianluigi, Donnarumma, Laura, Graziosi, Camilla, Le Grazie, Marco, Luzza, Francesco, Meucci, Costantino, Monterubbianesi, Rita, Pagnini, Cristiano, Perazzo, Patrizia, Pica, Roberta, Pranzo, Giuseppe, Rodino’, Stefano, Sacco, Rodolfo, Sebkova, Ladislava, Scarcelli, Antonella, Serio, Mariaelena, Napolitano, Daniele, Pugliese, Daniela, Schiavoni, Elisa, Turchini, Laura, Armuzzi, Alessandro, Zampaletta, Costantino, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
- Abstract
Background & Aims: Adalimumab (ADA) biosimilars have been included into the therapeutic armamentarium of inflammatory bowel disease (IBD); however, comparative data on the efficacy and safety of the different ADA biosimilars after replacing the ADA originator for a non-medical reason remains scarce. We aimed to compare in a real-life setting the efficacy and safety of four ADA biosimilars SB5, APB501, GP2017, and MSB11022 in IBD patients after replacing the originator for a non-medical reason.Methods: A multicenter retrospective study was performed on consecutive IBD patients, analyzing clinical, laboratory, and endoscopic data. The primary endpoints of the study were maintenance of clinical remission and safety of the different biosimilars.Results: 153 patients were enrolled, 26 with UC and 127 with CD. Clinical remission was maintained in 124 out of 153 (81%) patients after a median (IQR) follow-up of 12 (6-24) months, without any significant difference between the four ADA biosimilars. ADA biosimilars dosage was optimized in five patients (3.3%). Loss of remission was significantly higher in UC patients (10/26 patients, 38.5%) than in CD patients (19/127 patients, 14.9%, p<0.025). Adverse events occurred in 12 (7.9%) patients; the large majority were mild.Conclusions: No difference in efficacy and safety was found between ADA biosimilars when used to replace the ADA originator for a non-medical reason. However, in UC patients the replacement of ADA originator for this reason should be carefully assessed.
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- 2022
22. Lamina Propria CD4+LAP+ Regulatory T Cells Are Increased in Active Ulcerative Colitis but Show Increased IL-17 Expression and Reduced Suppressor Activity
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D’Ambrosio, Antonella, Cossu, Andrea, Amendola, Antonello, Zandri, Alessandro, Butera, Alessia, Sanchez, Massimo, Biffoni, Mauro, Pronio, Annamaria, Montesani, Chiara, Kohn, Anna, Pica, Roberta, and Boirivant, Monica
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- 2016
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23. Regional variations in the use of complementary and alternative medicines (CAM) for inflammatory bowel disease patients in Italy: An IG-IBD study
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Bertomoro, Perla, Renna, Sara, Cottone, Mario, Riegler, Gabriele, Bossa, Fabrizio, Giglio, Licio, Pastorelli, Luca, Papi, Claudio, Castiglione, Fabiana, Angelucci, Erika, Pica, Roberta, Di Paolo, Maria Carla, and D'Incà, Renata
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- 2010
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24. Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study
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Vermeire, Severine, primary, Lakatos, Peter L, additional, Ritter, Timothy, additional, Hanauer, Stephen, additional, Bressler, Brian, additional, Khanna, Reena, additional, Isaacs, Kim, additional, Shah, Saumin, additional, Kadva, Alysha, additional, Tyrrell, Helen, additional, Oh, Young S, additional, Tole, Swati, additional, Chai, Akiko, additional, Pulley, Jennifer, additional, Eden, Christopher, additional, Zhang, Wenhui, additional, Feagan, Brian G, additional, Abraham, Philip, additional, Acir Crippa Júnior, Mauro, additional, Aguilar, Humberto, additional, Ahmed, Tasneem, additional, Altorjay, Istvan, additional, Andersen, Vibeke, additional, Arai, Ronen, additional, Arnold, Hays, additional, Ausk, Karlee, additional, Axler, Jeffrey, additional, Ayub, Kamran, additional, Balekuduru, Avinash, additional, Barbalaco Neto, Guerino, additional, Bassan, Isaac, additional, Behm, Brian, additional, Bekal, Pradeep, additional, Bhatia, Shobna, additional, Bod, Barnabas, additional, Brandão Mello, Carlos Eduardo, additional, Brandeburova, Julia, additional, Breedt, Johannes, additional, Chopey, Ivan, additional, Connor, Michael, additional, Corlin, Richard, additional, Cortez Hernandez, Carlos Alejandro, additional, De, Arijit, additional, de Sá Rolim, Alexander, additional, Di Felice Boratto, Sandra, additional, Dixon, Tyler, additional, Dourado Poli, Debora, additional, Dresner, David, additional, Du Vall, George Aaron, additional, Ebert, Matthias, additional, Ehehalt, Robert, additional, Ertan, Atilla, additional, Escarcega Valencia, Ruben, additional, Etzel, Jason, additional, Fallingborg, Jan, additional, Feagan, Brian, additional, Fedurco, Miroslav, additional, Fernandez Castro, Enrique, additional, Ferreira de Almeida Borges, Valéria, additional, Finklestein, Mark, additional, Fischer, Andreas, additional, Fleisher, Mark, additional, Flores Rendon, Angel Ricardo, additional, Fogel, Ronald, additional, Franceschi Junior, Osvaldo, additional, Freedland, Curtis, additional, Gatof, David, additional, Gill, Kanwar, additional, Glerup, Henning, additional, Gokak, Vardaraj, additional, Goldin, Eran, additional, Gomez Jaramillo, Hector Alejandro, additional, Gupta, Nitin, additional, Gurzo, Zoltan, additional, Gyrina, Olga, additional, Habeeb, Mohammed Aejaz, additional, Hardi, Robert, additional, Harlan, William, additional, Hemaidan, Ammar, additional, Heyman, Melvin, additional, Hoffmann, Peter, additional, Holderman, William, additional, Holtkamp-Endemann, Frank, additional, Horvat, Gyula, additional, Israeli, Eran, additional, Jankiel Miszputen, Sender, additional, Jensen, Søren, additional, Johnson, Kenneth, additional, Jones, Jennifer, additional, Junior, Osvaldo, additional, Kadleckova, Barbora, additional, Kalla, Mukesh, additional, Kallo, Zsuzsanna, additional, Karyotakis, Nicholas, additional, Katz, Lior, additional, Katz, Leo, additional, Kaur, Nirmal, additional, Kohout, Pavel, additional, Lakatos, Peter, additional, Larriva de los Reyes, Emmanuel, additional, Lee, Robert, additional, Leman, Bernard, additional, Levchenko, Olena, additional, Levine, Henry, additional, Libanez Bessa Campelo Braga, Lúcia, additional, Loftus, Edward, additional, Lohdanidi, Tetiana, additional, Longman, Randy, additional, Lozano, Josefina, additional, Maaser, Christian, additional, Madi-Szabo, Laszlo, additional, Malluta, Everson Fernando, additional, Marshall, John, additional, Martinez Silva, Francisca, additional, Maynard, Kenneth, additional, Meder, Agnieszka, additional, Mehta, Chetan, additional, Minarik, Peter, additional, Mueller, Joachim, additional, Mukewar, Shrikant, additional, Nagy, Bela, additional, Neiko, Vasyl, additional, Neurath, Markus, additional, Nichol, Brian, additional, Novick, James, additional, Pai, Nitin, additional, Pandak, William, additional, Panigrahi, Sarat, additional, Pape, Ulrich-Frank, additional, Paraná, Raymundo, additional, Parekh, Nimisha, additional, Patel, Bhaktasharan, additional, Pecsi, Gyula, additional, Peralta, Sergio, additional, Pesta, Martin, additional, Peterfai, Eva, additional, Petruzzellis, Carlo, additional, Petryka, Robert, additional, Pica, Roberta, additional, Piniella, Carlos, additional, Pratha, Vijayalakshmi, additional, Prochazka, Vlastimil, additional, Prokopchuk, Sergey, additional, Prystupa, Ludmyla, additional, Puri, Amarender, additional, Rainis, Tova, additional, Ramesh Kumar, Bhashyakarla, additional, Ramos Júnior, Odery, additional, Rishko, Iaroslava, additional, Robbins, Bryan, additional, Rock, Elizabeth, additional, Rodrigues Borba, Marcelo, additional, Rodriguez, Miguel, additional, Rozciecha, Jerzy, additional, Ruiz Flores, Azalia Yuriria, additional, Rydzewska, Grazyna, additional, Safadi, Rifaat, additional, Saibeni, Simone, additional, Schirbel, Anja, additional, Schmiegel, Wolff, additional, Schnabel, Róbert, additional, Schneider, Herbert, additional, Segui, Armando, additional, Seidelin, Jakob, additional, Seidler, Ursula, additional, Sellin, Joseph, additional, Shafran, Ira, additional, Sheikh, Aasim, additional, Sherman, Alex, additional, Shirin, Haim, additional, Shukla, Akash, additional, Siddiqui, Firdous, additional, Sike, Robert, additional, Sood, Ajit, additional, Stallmach, Andreas, additional, Stanislavchuk, Mykola, additional, Staun, Michael, additional, Stein, Daniel, additional, Steinberg, Alon, additional, Steinhart, Hillary, additional, Stifft, Jonathas, additional, Tandon, Rakesh, additional, Tantry, Vishwanath, additional, Thiwan, Syed, additional, Treiber, Matthias, additional, Ulbrych, Jan, additional, Valentine, John, additional, Vasudeva, Rajeev, additional, Vaughn, Byron, additional, Velasco, Brenda, additional, Vincze, Aron, additional, Volfova, Miroslava, additional, Waterman, Mattitiahu, additional, Weiss, L. Michael, additional, Wiesner, Elise, additional, Williams, Alonzo, additional, Witthoeft, Thomas, additional, Wohlman, Robert, additional, Wright, John, additional, Yamamoto Furusho, Jesus Kazuo, additional, Younes, Ziad, additional, Yousuf, Khurshid, additional, Zborivskyy, Yaroslav, additional, Zeuzem, Stefan, additional, and Zhdan, Vyacheslav, additional
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- 2022
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25. Comparison of performances of infliximab biosimilars CT-P13 versus SB2 in the treatment of inflammatory bowel diseases: a real-life multicenter, observational study in Italy
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Tursi, Antonio, primary, Mocci, Giammarco, additional, Allegretta, Leonardo, additional, Aragona, Giovanni, additional, Bianco, Maria Antonia, additional, Colucci, Raffaele, additional, Cuomo, Antonio, additional, Della Valle, Nicola, additional, Ferronato, Antonio, additional, Forti, Giacomo, additional, Gaiani, Federica, additional, Graziani, Maria Giovanna, additional, Lorenzetti, Roberto, additional, Luzza, Francesco, additional, Paese, Pietro, additional, Penna, Antonio, additional, Pica, Roberta, additional, Pranzo, Giuseppe, additional, Rodinò, Stefano, additional, Scarcelli, Antonella, additional, Zampaletta, Costantino, additional, Brozzi, Lorenzo, additional, Cicerone, Clelia, additional, Cocco, Andrea, additional, De’ Angelis, Gianluigi, additional, Donnarumma, Laura, additional, Fiorella, Serafina, additional, Iannelli, Chiara, additional, Larussa, Tiziana, additional, Le Grazie, Marco, additional, Luppino, Ileana, additional, Meucci, Costantino, additional, FaggianI, Roberto, additional, Pagnini, Cristiano, additional, Perazzo, Patrizia, additional, Rodriguez-Castro, Kryssia Isabel, additional, Sacco, Rodolfo, additional, Sebkova, Ladislava, additional, Serio, Mariaelena, additional, De Monti, Alberta, additional, Picchio, Marcello, additional, Napolitano, Daniele, additional, Schiavoni, Elisa, additional, Turchini, Laura, additional, Scaldaferri, Franco, additional, Pugliese, Daniela, additional, Guidi, Luisa, additional, Laterza, Lucrezia, additional, Privitera, Giuseppe, additional, Pizzoferrato, Marco, additional, Lopetuso, Loris R., additional, Armuzzi, Alessandro, additional, Elisei, Walter, additional, Maconi, Giovanni, additional, and Papa, Alfredo, additional
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- 2021
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26. Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohnʼs Disease
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Monteleone, Giovanni, Neurath, Markus F., Ardizzone, Sandro, Di Sabatino, Antonio, Fantini, Massimo C., Castiglione, Fabiana, Scribano, Maria L., Armuzzi, Alessandro, Caprioli, Flavio, Sturniolo, Giacomo C., Rogai, Francesca, Vecchi, Maurizio, Atreya, Raja, Bossa, Fabrizio, Onali, Sara, Fichera, Maria, Corazza, Gino R., Biancone, Livia, Savarino, Vincenzo, Pica, Roberta, Orlando, Ambrogio, and Pallone, Francesco
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- 2015
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27. Colonic Involvement in Celiac Disease and Possible Implications of the Sigmoid Mucosa Organ Culture in its Diagnosis
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Picarelli, Antonio, Di Tola, Marco, Borghini, Raffaele, Isonne, Claudia, Saponara, Annarita, Marino, Mariacatia, Casale, Rossella, Tiberti, Antonio, Pica, Roberta, Donato, Giuseppe, Frieri, Giuseppe, and Corazziari, Enrico
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- 2013
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28. SARS-CoV-2: lessons from both the history of medicine and from the biological behavior of other well-known viruses
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Fiorino, Sirio, primary, Tateo, Fabio, additional, Biase, Dario De, additional, Gallo, Claudio G, additional, Orlandi, Paolo E, additional, Corazza, Ivan, additional, Budriesi, Roberta, additional, Micucci, Matteo, additional, Visani, Michela, additional, Loggi, Elisabetta, additional, Hong, Wandong, additional, Pica, Roberta, additional, Lari, Federico, additional, and Zippi, Maddalena, additional
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- 2021
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29. Sars-Cov-2 Pandemic: A Narrative Review on Lessons and Viewpoints Arising From Both the History of Medicine and From the Biological Behaviour of Other Well-Known Viruses
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Fiorino, Sirio, Tateo, Fabio, Biase, Dario De, Gallo, Claudio Giuseppe, Orlandi, Paolo Emilio, Corazza, Ivan, Budriesi, Roberta, Micucci, Matteo, Visani, Michela, Loggi, Elisabetta, Hong, Wandong, Pica, Roberta, Lari, Federico, and Zippi, Maddalena
- Subjects
viruses ,allergology ,virus diseases - Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of the current pandemic worldwide. The pathological condition induced by this pathogen is known as COVID-19 disease. SARS-CoV-2 associated pandemic has been defined as a “public health emergency of international concern” by the International Health Regulation Emergency Committee of the World Health Organization. To date, considerable efforts are in progress to develop more advanced strategies against SARS-CoV-2. Despite the numerous scientific studies published, our knowledge regarding this pathogen is still incomplete, as this virus has been identified only recently. Therefore, scientific investigation of the SARS-CoV-2 has been possible only for a short period of time and effective management of the serious forms of this disease is still lacking. Considerable efforts are in progress worldwide with the purpose to develop more advanced strategies against this pathogen. In this review, we have analyzed the structural and the biological SARS-CoV-2 characteristics and those of other well-known RNA viruses, with the aim to identify possible similarities and analogies between all these pathogens, may be a very useful approach. These infectious agents have been widely studied since several years ago and, a large series of scientific reports are available in the literature regarding this topic. Therefore, focusing on the Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV) and Influenza viruses (IVs), we have collected their historical data, clinical manifestations, pathogenetic mechanisms and related infections. Taking advantage of the results of our research, we have assembled this narrative review, with the aim to get useful insights and lessons from HIV, HCV and IVs characteristics and, consequently, to transfer the obtained knowledge to the study of SARS-CoV-2 biology. There are well known differences between all these pathogens. In particular, they present a distinct mode of transmission, as SARS-CoV-2 and Influenza viruses are airborne pathogens, whereas HIV and HCV are bloodborne infectious agents. However, these viruses exhibit some potential common clinical manifestations and pathogenetic mechanisms and their understanding may contribute to establishing preventive measures and new therapies against SARS-CoV-2. Accordingly, we have analysed and discussed the following points: 1) the biology, the pathogenesis and the clinical manifestations of SARS-CoV-2, HIV, HCV and IVs in mankind; 2) the onset and spreading of pandemics caused by respiratory viruses according to a perspective historical point of view; 3) the possible development of a persistent SARS-CoV-2 reservoir worldwide; 4) the possibility of SARS-CoV-2 reinfection/reactivation; 5) the possible involvement and impact of climatic factors in increasing the risk of SARS-CoV-2 spreading.
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- 2021
30. Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett’s oesophagus and adenocarcinoma
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Crispino, Pietro, Alò, Piero Luigi, Rivera, Margherita, Barillà, Domenica, Nardi, Francesco, Mariotti, Mauro, Giancarlo, Zotti, Botti, Claudio, Pica, Roberta, Cassieri, Claudio, Unim, Hans, and Paoluzi, Paolo
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- 2009
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31. Hematological malignancies in chronic inflammatory bowel diseases: report of five cases and review of the literature
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Crispino, Pietro, Pica, Roberta, Angelucci, Erika, Consolazio, Adriana, Rivera, Margherita, Cassieri, Claudio, and Paoluzi, Paolo
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- 2007
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32. Splenic Hematoma as a Rare Complication of Colonoscopy; a Case Report
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Zippi, Maddalena, Pica, Roberta, Febbraro, Ingrid, Pugliese, Francesco Rocco, and Liguori, Francesca
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colonoscopy ,hematoma ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Case Report ,spleen ,computed tomography ,lcsh:RC86-88.9 ,splenic rupture - Abstract
Splenic injuries after colonoscopy are an uncommon complication, which can lead to potentially unfortunate outcomes. Their management depends on the type of the splenic damage (hematomas, lacerations, rupture). We describe the case of a woman who visited the Emergency Department due to abdominal pain and pre-syncopal condition, which had occurred 12 hours after she underwent a colonoscopy. An abdominal computed tomography scan showed a splenic hematoma and a hemoperitoneum. An emergency splenectomy was performed successfully. Emergency physicians, who are at the forefront of diagnosing and treating patients, should consider this post-endoscopic complication in order to implement a prompt treatment.
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- 2020
33. Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis
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Zippi, Maddalena, primary, Fiorino, Sirio, additional, Budriesi, Roberta, additional, Micucci, Matteo, additional, Corazza, Ivan, additional, Pica, Roberta, additional, de Biase, Dario, additional, Gallo, Claudio Giuseppe, additional, and Hong, Wandong, additional
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- 2021
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34. An Ulcerated Large Colic Lipoma Causing Rectorrhagia Treated With Endoscopic Loop-Assisted Resection
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Zippi, Maddalena, primary, Toma, Antonella, additional, Paoluzi, Nada, additional, Maccioni, Francesca, additional, and Pica, Roberta, additional
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- 2021
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35. Long-term real-life efficacy and safety of infliximab and adalimumab in the treatment of inflammatory bowel diseases outpatients
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Tursi, Antonio, primary, Mocci, Giammarco, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Brandimarte, Giovanni, additional, Cassieri, Claudio, additional, Colucci, Raffaele, additional, De Medici, Antonio, additional, Faggiani, Roberto, additional, Ferronato, Antonio, additional, Fiorella, Serafina, additional, Forti, Giacomo, additional, Franceschi, Marilisa, additional, Gallina, Sara, additional, Giorgetti, GianMarco, additional, Grasso, Giuseppina, additional, Larussa, Tiziana, additional, Luzza, Francesco, additional, Penna, Antonio, additional, Pica, Roberta, additional, Piergallini, Simona, additional, Porciello, Sarah, additional, Pranzo, Giuseppe, additional, Rodino’, Stefano, additional, Scorza, Stefano, additional, Sebkova, Ladislava, additional, Zampaletta, Costantino, additional, Elisei, Walter, additional, and Picchio, Marcello, additional
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- 2021
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36. Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications
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Pagnini, Cristiano, primary, Picchianti-Diamanti, Andrea, additional, Bruzzese, Vincenzo, additional, Lorenzetti, Roberto, additional, Luchetti, Michele Maria, additional, Martin Martin, Louis Severino, additional, Pica, Roberta, additional, Scolieri, Palma, additional, Scribano, Maria Lia, additional, Zampaletta, Costantino, additional, Chimenti, Maria Sole, additional, and Lagana, Bruno, additional
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- 2021
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37. Candida Albicans Lung Abscess in an Illicit Drugs User With Hepatitis C Virus Chronic Infection
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Zippi, Maddalena, primary, Toma, Antonella, additional, Maccioni, Francesca, additional, and Pica, Roberta, additional
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- 2021
- Full Text
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38. Optimal duration of maintenance treatment with azathioprine in patients with inflammatory bowel disease: PR0322: IBD
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PICA, ROBERTA, AVALLONE, ELEONORAVERONICA, CASSIERI, CLAUDIO, DE CAROLIS, AURORA, ZIPPI, MADDALENA, VERNIA, PIERO, and PAOLUZI, PAOLO
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- 2013
39. Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature
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Lande, Roberto, primary, Mennella, Anna, additional, Palazzo, Raffaella, additional, Pietraforte, Immacolata, additional, Stefanantoni, Katia, additional, Iannace, Nicoletta, additional, Butera, Alessia, additional, Boirivant, Monica, additional, Pica, Roberta, additional, Conrad, Curdin, additional, Chizzolini, Carlo, additional, Riccieri, Valeria, additional, and Frasca, Loredana, additional
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- 2020
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40. Mo1772 LONG-TERM OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION STRATEGY FOR LARGE SUPERFICIAL NEOPLASMS IN INFLAMMATORY BOWEL DISEASES
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Iacopini, Federico, primary, Pica, Roberta, additional, Calabrese, Emma, additional, Montagnese, Fabrizio, additional, Antenucci, Claudia, additional, Gotoda, Takuji, additional, Costamagna, Guido, additional, and Saito, Yutaka, additional
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- 2020
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41. Enteropathic spondyloarthritis: Results from a large nationwide database analysis
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Picchianti-Diamanti, Andrea, primary, Lorenzetti, Roberto, additional, Chimenti, Maria Sole, additional, Luchetti, Michele Maria, additional, Conigliaro, Paola, additional, Canofari, Claudia, additional, Benfaremo, Devis, additional, Bruzzese, Vincenzo, additional, Laganà, Bruno, additional, Perricone, Roberto, additional, Zullo, Angelo, additional, Caso, Francesco, additional, Costa, Luisa, additional, Tomietto, Paola, additional, Fabio, Fischetti, additional, Scolieri, Palma, additional, Navarini, Luca, additional, Cuccagna, Elisa, additional, Severino Martin-Martin, Luis, additional, Lia Scribano, Maria, additional, Faggiani, Roberto, additional, Pagnini, Cristiano, additional, Mocci, Giammarco, additional, Demurtas, Mauro, additional, Tursi, Antonio, additional, Festa, Stefano, additional, Zerboni, Giulia, additional, Pica, Roberta, additional, Ridola, Lorenzo, additional, Paroli, Marino, additional, Baccini, Flavia, additional, Baincone, Livia, additional, Gabrielli, Armando, additional, Afeltra, Antonella, additional, and Scarpa, Raffaele, additional
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- 2020
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42. 2-Week Triple Therapy for Helicobacter pylori Infection is Better Than 1-Week in Clinical Practice: a Large Prospective Single-Center Randomized Study
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Paoluzi, Paolo, Iacopini, Federico, Crispino, Pietro, Nardi, Francesco, Bella, Antonino, Rivera, Margherita, Rossi, Pina, Gurnari, Maurizio, Caracciolo, Francesco, Zippi, Maddalena, and Pica, Roberta
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- 2006
43. Anti-tissue transglutaminase antibodies in inflammatory bowel disease: new evidence
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Tola, Marco Di, Sabbatella, Luigi, Anania, Maria Cristina, Viscido, Angelo, Caprilli, Renzo, Pica, Roberta, Paoluzi, Paolo, and Picarelli, Antonio
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- 2004
44. Oxidative Damage of the Gastric Mucosa in Helicobacter pylori Positive Chronic Atrophic and Nonatrophic Gastritis, Before and After Eradication
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Iacopini, Federico, Consolazio, Adriana, Bosco, Daniela, Marcheggiano, Adriana, Bella, Antonino, Pica, Roberta, Paoluzi, Omero A., Crispino, Pietro, Rivera, Margherita, Mottolese, Marcella, Nardi, Francesco, and Paoluzi, Paolo
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- 2003
45. Discrepancy Between Polymerase Chain Reaction Assay and Western Blot Analysis in the Assessment of CagA Status in Dyspeptic Patients
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Paoluzi, Omero Alessandro, Rossi, Pina, Montesano, Carla, Bernardi, Sabrina, Carnieri, Emanuela, Marchione, Orazio Paolo, Nardi, Francesco, Iacopini, Federico, Pica, Roberta, and Paoluzi, Paolo
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- 2001
46. IL-13 mRNA Tissue Content Identifies Two Subsets of Adult Ulcerative Colitis Patients With Different Clinical and Mucosa-Associated Microbiota Profiles
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Butera, Alessia, primary, Di Paola, Monica, primary, Vitali, Francesco, primary, De Nitto, Daniela, primary, Covotta, Francesco, primary, Borrini, Francesco, primary, Pica, Roberta, primary, De Filippo, Carlotta, primary, Cavalieri, Duccio, primary, Giuliani, Alessandro, primary, Pronio, Annamaria, primary, and Boirivant, Monica, primary
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- 2019
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47. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Fiorino, Gionata, primary, Caprioli, Flavio, additional, Daperno, Marco, additional, Mocciaro, Filippo, additional, Principi, Mariabeatrice, additional, Viscido, Angelo, additional, Fantini, Massimo Claudio, additional, Orlando, Ambrogio, additional, Papi, Claudio, additional, Annese, Vito, additional, Danese, Silvio, additional, Vecchi, Maurizio, additional, Rizzello, Fernando, additional, Armuzzi, Alessandro, additional, Leone, Salvatore, additional, Previtali, Enrica, additional, Aloi, Marina, additional, Alvisi, Patrizia, additional, Antonelli, Elisabetta, additional, Ardizzone, Sandro, additional, Astegiano, Marco, additional, Baldoni, Monia, additional, Beltrami, Marina, additional, Biancone, Livia, additional, Bodini, Giorgia, additional, Buda, Andrea, additional, Bossa, Fabrizio, additional, Bracci, Fiammetta, additional, Calabrese, Emma, additional, Cappello, Maria, additional, Castiglione, Fabiana, additional, Ciacci, Carolina, additional, Cicala, Michele, additional, Ciccocioppo, Rachele, additional, Comberlato, Michele, additional, Cortelezzi, Claudio Camillo, additional, Cosintino, Rocco, additional, Costa, Francesco, additional, Costantino, Giuseppe, additional, Cucchiara, Salvatore, additional, Cuomo, Antonio, additional, D’Incà, Renata, additional, Di Paolo, Maria Carla, additional, Di Sabatino, Antonio, additional, Di Sario, Antonio, additional, Frieri, Giuseppe, additional, Fries, Walter, additional, Gasbarrini, Antonio, additional, Geccherle, Andrea, additional, Gionchetti, Paolo, additional, Graziani, Maria Giovanna, additional, Grossi, Laurino, additional, Guidi, Luisa, additional, Imperiali, Gianni, additional, Latella, Giovanni, additional, Lionetti, Paolo, additional, Inserra, Gaetano, additional, Maconi, Giovanni, additional, Manguso, Francesco, additional, Marino, Marco, additional, Mastronardi, Mauro, additional, Mazzuoli, Silvia, additional, Meucci, Gianmichele, additional, Mendolaro, Marco, additional, Milla, Monica, additional, Mocci, Giammarco, additional, Monteleone, Giovanni, additional, Bortoluzzi, Francesco Neri, additional, Pagnini, Cristiano, additional, Pastorelli, Luca, additional, Pica, Roberta, additional, Piergallini, Simona, additional, Privitera, Antonello, additional, Renna, Sara, additional, Ribaldone, Davide Giuseppe, additional, Ricci, Chiara, additional, Rispo, Antonio, additional, Rocca, Rodolfo, additional, Romano, Claudio, additional, Romano, Marco, additional, Russo, Giovanni, additional, Sablich, Renato, additional, Saibeni, Simone, additional, Savarino, Edoardo, additional, Scribano, Maria Lia, additional, Spagnuolo, Rocco, additional, Stasi, Elisa, additional, Terpin, Maria Maddalena, additional, Testa, Anna, additional, Valpiani, Daniela, additional, Variola, Angela, additional, Vernia, Piero, additional, Vitale, Giovanna, additional, and Zoli, Giorgio, additional
- Published
- 2019
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48. Comparison of performances of infliximab biosimilars CT-P13 versus SB2 in the treatment of inflammatory bowel diseases: a real-life multicenter, observational study in Italy
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Tursi, Antonio, Mocci, Giammarco, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Cuomo, Antonio, Della Valle, Nicola, Ferronato, Antonio, Forti, Giacomo, Gaiani, Federica, Graziani, Maria Giovanna, Lorenzetti, Roberto, Luzza, Francesco, Paese, Pietro, Penna, Antonio, Pica, Roberta, Pranzo, Giuseppe, Rodinò, Stefano, Scarcelli, Antonella, Zampaletta, Costantino, Brozzi, Lorenzo, Cicerone, Clelia, Cocco, Andrea, De’ Angelis, Gianluigi, Donnarumma, Laura, Fiorella, Serafina, Iannelli, Chiara, Larussa, Tiziana, Le Grazie, Marco, Luppino, Ileana, Meucci, Costantino, FaggianI, Roberto, Pagnini, Cristiano, Perazzo, Patrizia, Rodriguez-Castro, Kryssia Isabel, Sacco, Rodolfo, Sebkova, Ladislava, Serio, Mariaelena, De Monti, Alberta, Picchio, Marcello, Napolitano, Daniele, Schiavoni, Elisa, Turchini, Laura, Scaldaferri, Franco, Pugliese, Daniela, Guidi, Luisa, Laterza, Lucrezia, Privitera, Giuseppe, Pizzoferrato, Marco, Lopetuso, Loris R., Armuzzi, Alessandro, Elisei, Walter, Maconi, Giovanni, and Papa, Alfredo
- Abstract
ABSTRACTBackgroundTo compare the performances of Infliximab (IFX) biosimilar CT-P13 and SB2 in the treatment of Inflammatory Bowel Diseases (IBD) outpatients in Italy.Research Design and MethodsThree hundred and eighty IBD outpatients were retrospectively evaluated. The primary endpoint was to compare the two IFX biosimilars in terms of reaching and maintenance of remission at any timepoint.Results197 patients with Ulcerative Colitis (UC) and 183 patients with Crohn’s Disease (CD) treated with CT-P13 or SB2 and having a median (IQR) follow-up of 12 (6–36) months were compared: 230 (60.5%) were naïve to anti-TNFα, 20 (5.26%) were switched from IFX originator or from IFX CT-P13 to IFX SB2. Clinical remission was achieved in 133 (67.5%) UC patients and in 164 (89.6%) CD patients (p < 0.000), with no differences between CT-P13 and SB2 in the rate of remission in UC (p = 0.667) and CD (p = 0.286). Clinical response, steroid-free remission, rate of surgery, mucosal healing (MH) in UC, switching from IFX originator or from other biosimilar, and safety were similar. Higher MH rate was obtained in CD patients treated with CT-P13 (p = 0.004).ConclusionThis first comparative study found that both IFX biosimilars CT-P13 and SB2 are effective and safe in managing IBD outpatients.
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- 2022
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49. Hepatitis B (HBV) reactivation in patients receiving biologic therapy for chronic inflammatory diseases in clinical practice.
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Ridola, Lorenzo, Zullo, Angelo, Laganà, Bruno, Lorenzetti, Roberto, Migliore, Alberto, Pica, Roberta, Diamanti, Andrea Picchianti, Gigliucci, Gianfranco, Scolieri, Palma, and Bruzzese, Vincenzo
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- 2021
- Full Text
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50. Stimulated Human Lamina Propria T Cells Manifest Enhanced Fas-mediated Apoptosis
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Boirivant, Monica, Pica, Roberta, DeMaria, Ruggero, Testi, Roberto, Pallone, Francesco, and Strober, Warren
- Published
- 1996
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