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393 results on '"Pientong, Chamsai"'

5. The Dual Functions of Andrographolide in the Epstein–Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein–Barr Virus and the Induction of Cell Death

Author

Heawchaiyaphum, Chukkris, primary, Malat, Praphatson, additional, Pientong, Chamsai, additional, Roytrakul, Sittiruk, additional, Yingchutrakul, Yodying, additional, Aromseree, Sirinart, additional, Suebsasana, Supawadee, additional, Mahalapbutr, Panupong, additional, and Ekalaksananan, Tipaya, additional

Published
2023
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13. The Inhibitory Effect of Kerra TM , KS TM , and Minoza TM on Human Papillomavirus Infection and Cervical Cancer.

Author

Choowongkomon, Kiattawee, Choengpanya, Khuanjarat, Pientong, Chamsai, Ekalaksananan, Tipaya, Talawat, Sulak, Srathong, Pussadee, and Chuerduangphui, Jureeporn

Subjects
HUMAN papillomavirus, PAPILLOMAVIRUS diseases, CERVICAL cancer, HELA cells, CELL populations
Abstract

Background and Objectives: Cervical cancer is one of the most common types of frequently found cancers in Thailand. One of the causative agents is the infection of the high-risk human papillomavirus (HPV) type 16 and 18. Traditional medicines are rich sources of bioactive compounds which are a valuable source for the development of novel cancer therapies. In this study, the therapeutic effects of 3 traditional medicines, KerraTM, KSTM, and MinozaTM, were studied on HeLa and CaSki cells. Materials and Methods: The effects of KerraTM, KSTM, and MinozaTM on cancer cells were evaluated through cytotoxicity and cell death assays. The infection assay using HPV-16 pseudovirus was also carried out. Results: All traditional medicines efficiently suppressed cell growths of HeLa and CaSki, with KerraTM being the most potent anticancer agent followed by KSTM and MinozaTM. KerraTM at 158 µg/mL and 261 µg/mL significantly increases the percentage inhibition of the HPV-16 pseudovirus infection in a pre-attachment step in a dose-dependent manner, while KSTM at 261 µg/mL efficiently inhibited viral infection in both pre-attachment and adsorption steps. However, KerraTM, KSTM, and MinozaTM at subtoxic concentrations could not reduce the viral E6 mRNA expressions of HPV-16 and HPV-18. Cell death assay by acridine orange/ethidium bromide showed that KerraTM increased population of dead cells in dose-dependent manner in both CaSki and HeLa. The percentage of secondary necrosis in KerraTM-treated CaSki was higher than that of HeLa cells, while the percentage of late apoptotic cells in HeLa was higher than that of CaSki, indicating that HeLa was more susceptible to KerraTM than CaSki. For KSTM and MinozaTM, these extracts at 250 µg/mL promoted autophagy over cell death. At 500 µg/mL, the percentage of dead cells in KerraTM was higher than that of KSTM and MinozaTM. Conclusions: KerraTM is a potent traditional medicine for promoting cancer cell death. KerraTM is possibly useful in the prevention and treatment of cervical cancer. Further investigation will be carried out to gain a better understanding of the biochemical mechanism and the pharmacological activity underlying this effect. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Epidemiological evidence and association of human papillomavirus with esophageal cancer in northeastern Thailand: a case–control study

Author

Burassakarn, Ati, primary, Pientong, Chamsai, additional, Tongchai, Panwad, additional, Wongjampa, Weerayut, additional, Poosari, Arisara, additional, Udomsin, Apiradee, additional, Sa-ngiamwibool, Prakasit, additional, Ungareewittaya, Piti, additional, Nutravong, Thitima, additional, and Ekalaksananan, Tipaya, additional

Published
2023
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15. Intrahost Genetic Diversity of Dengue Virus in Human Hosts and Mosquito Vectors under Natural Conditions Which Impact Replicative Fitness In Vitro

Author

Nonyong, Patcharaporn, primary, Ekalaksananan, Tipaya, additional, Phanthanawiboon, Supranee, additional, Overgaard, Hans J., additional, Alexander, Neal, additional, Thaewnongiew, Kesorn, additional, Sawaswong, Vorthon, additional, Nimsamer, Pattaraporn, additional, Payungporn, Sunchai, additional, Phadungsombat, Juthamas, additional, Nakayama, Emi E., additional, Shioda, Tatsuo, additional, and Pientong, Chamsai, additional

Published
2023
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16. Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human Papillomavirus E6/E7 RNA Staining Patterns

Author

Bumrungthai, Sureewan, primary, Ekalaksananan, Tipaya, additional, Kleebkaow, Pilaiwan, additional, Pongsawatkul, Khajohnsilp, additional, Phatnithikul, Pisit, additional, Jaikan, Jirad, additional, Raumsuk, Puntanee, additional, Duangjit, Sureewan, additional, Chuenchai, Datchani, additional, and Pientong, Chamsai, additional

Published
2023
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19. Human Oncogenic Epstein–Barr Virus in Water and Human Blood Infection of Communities in Phayao Province, Thailand

Author

Pongpakdeesakul, Sutida, primary, Ekalaksananan, Tipaya, additional, Pientong, Chamsai, additional, Iamchuen, Niti, additional, Buddhisa, Surachat, additional, Mahingsa, Khwanruedee, additional, Pingyod, Arunee, additional, Sangsrijun, Wanwipa, additional, Passorn, Supaporn, additional, Chopjitt, Peechanika, additional, Duangjit, Sureewan, additional, and Bumrungthai, Sureewan, additional

Published
2023
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24. Characterization and Involvement of Exosomes Originating from Chikungunya Virus-Infected Epithelial Cells in the Transmission of Infectious Viral Elements

Author

Le, Bao Chi Thi, primary, Burassakarn, Ati, additional, Tongchai, Panwad, additional, Ekalaksananan, Tipaya, additional, Aromseree, Sirinart, additional, Phanthanawiboon, Supranee, additional, Polsan, Yada, additional, Alexander, Neal, additional, Overgaard, Hans J., additional, and Pientong, Chamsai, additional

Published
2022
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33. Mathematical Modelling of Cervical Precancerous Lesion Grade Risk Scores: Linear Regression Analysis of Cellular Protein Biomarkers and Human Papillomavirus E6 / E7 RNA Staining Patterns.

Author

Bumrungthai, Sureewan, Ekalaksananan, Tipaya, Kleebkaow, Pilaiwan, Pongsawatkul, Khajohnsilp, Phatnithikul, Pisit, Jaikan, Jirad, Raumsuk, Puntanee, Duangjit, Sureewan, Chuenchai, Datchani, and Pientong, Chamsai

Subjects
DISEASE risk factors, HUMAN papillomavirus, PRECANCEROUS conditions, REGRESSION analysis, CELL analysis, P16 gene
Abstract

The current practice of determining histologic grade with a single molecular biomarker can facilitate differential diagnosis but cannot predict the risk of lesion progression. Cancer is caused by complex mechanisms, and no single biomarker can both make accurate diagnoses and predict progression risk. Modelling using multiple biomarkers can be used to derive scores for risk prediction. Mathematical models (MMs) may be capable of making predictions from biomarker data. Therefore, this study aimed to develop MM–based scores for predicting the risk of precancerous cervical lesion progression and identifying precancerous lesions in patients in northern Thailand by evaluating the expression of multiple biomarkers. The MMs (Models 1–5) were developed in the test sample set based on patient age range (five categories) and biomarker levels (cortactin, p16INK4A, and Ki–67 by immunohistochemistry [IHC], and HPV E6/E7 ribonucleic acid (RNA) by in situ hybridization [ISH]). The risk scores for the prediction of cervical lesion progression ("risk biomolecules") ranged from 2.56–2.60 in the normal and low–grade squamous intraepithelial lesion (LSIL) cases and from 3.54–3.62 in cases where precancerous lesions were predicted to progress. In Model 4, 23/86 (26.7%) normal and LSIL cases had biomolecule levels that suggested a risk of progression, while 5/86 (5.8%) cases were identified as precancerous lesions. Additionally, histologic grading with a single molecular biomarker did not identify 23 cases with risk, preventing close patient monitoring. These results suggest that biomarker level–based risk scores are useful for predicting the risk of cervical lesion progression and identifying precancerous lesion development. This multiple biomarker–based strategy may ultimately have utility for predicting cancer progression in other contexts. [ABSTRACT FROM AUTHOR]

Published
2023
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37. sj-docx-2-avc-10.1177_20402066221089724 - Supplemental material for Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model

Author

Chuerduangphui, Jureeporn, Nukpook, Thawaree, Pientong, Chamsai, Aromdee, Chantana, Suebsasana, Supawadee, Khunkitti, Watcharee, So-in, Charinya, Proyrungroj, Kanisara, and Ekalaksananan, Tipaya

Subjects
FOS: Clinical medicine, FOS: Biological sciences, Cell Biology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-2-avc-10.1177_20402066221089724 for Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model by Jureeporn Chuerduangphui, Thawaree Nukpook, Chamsai Pientong, Chantana Aromdee, Supawadee Suebsasana, Watcharee Khunkitti, Charinya So-in, Kanisara Proyrungroj and Tipaya Ekalaksananan in Antiviral Chemistry and Chemotherapy

Published
2022
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46. Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018

Author

Nonyong, Patcharaporn, primary, Ekalaksananan, Tipaya, additional, Phanthanawiboon, Supranee, additional, Aromseree, Sirinart, additional, Phadungsombat, Juthamas, additional, Nakayama, Emi E., additional, Shioda, Tatsuo, additional, Sawaswong, Vorthon, additional, Payungporn, Sunchai, additional, Thaewnongiew, Kesorn, additional, Overgaard, Hans J., additional, Bangs, Michael J., additional, Alexander, Neal, additional, and Pientong, Chamsai, additional

Published
2021
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47. Development and Comparison of Dengue Vulnerability Indices Using GIS-Based Multi-Criteria Decision Analysis in Lao PDR and Thailand

Author

Zafar, Sumaira, primary, Shipin, Oleg, additional, Paul, Richard E., additional, Rocklöv, Joacim, additional, Haque, Ubydul, additional, Rahman, Md. Siddikur, additional, Mayxay, Mayfong, additional, Pientong, Chamsai, additional, Aromseree, Sirinart, additional, Poolphol, Petchaboon, additional, Pongvongsa, Tiengkham, additional, Vannavong, Nanthasane, additional, and Overgaard, Hans J., additional

Published
2021
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