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377 results on '"Pieper, L"'

6. Evaluating risk-based allocation strategies for PCSK9 inhibitors: results from a simulation study in a contemporary ASCVD cohort

Author

Blaum, C, primary, Gossling, A, additional, Bay, B, additional, Arnold, N, additional, Rohde, J, additional, Pieper, L, additional, Pfingstgraeff, F, additional, Lorenz, T, additional, Zeller, T, additional, Schnabel, R, additional, Seiffert, M, additional, Kirchhof, P, additional, Blankenberg, S, additional, Waldeyer, C, additional, and Brunner, F J, additional

Published
2023
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16. Measuring Voice Effects of Vibrato-Free and Ingressive Singing : A Study of Phonation Threshold Pressures

Author

Fornhammar, L., Sundberg, Johan, Fuchs, M., Pieper, L., Fornhammar, L., Sundberg, Johan, Fuchs, M., and Pieper, L.

Abstract

Background: Phonation threshold pressure (PTP), showing the lowest subglottal pressure producing vocal fold vibration, has been found useful for documenting various effects of phonatory conditions. The need for such documentation is relevant also to the teaching of singing, particularly in view of vocal demands raised in some contemporary as well as early music compositions. The aim of the present study was to test the usefulness of PTP measurement for evaluating phonatory effects of vibrato-free and ingressive singing in professional singers. Methods: PTP was measured at a middle, a high and a low pitch in two female and two male singers before and after recording voice range profiles (i) in habitual technique, ie, with vibrato, (ii) in vibrato-free, and (iii) in ingressive phonation. Effects on vocal fold status were examined by videolaryngostroboscopy. Results: After careful instruction of the singers, no problems were found in applying the PTP method. In some singers videolaryngostroboscopy showed effects after the experiment, eg, in terms of increased mucus and more complete glottal closure. After ingressive phonation PTP increased substantially at high pitch in one singer but changed marginally in the other singers. Conclusion: The method seems useful for assessing and interpreting effects of singing in different styles and as a part of voice diagnostics. Therefore, it seems worthwhile to automatize PTP measurement., QC 20220912

Published
2022
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22. Analysis of the tumor microenvironment by whole-slide image analysis identifies low B cell content as a predictor of adverse outcome in advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Author

Jachimowicz, R., Pieper, L., Reinke, S., Gontarewicz, A., Plutschow, A., Haverkamp, H., Frauenfeld, L., Fend, F., Overkamp, M., Jochims, F., Thorns, C., Hansmann, M., Moller, P., Rosenwald, A., Stein, H., Reinhardt, H., Borchmann, P., von Tresckow, B., Engert, A., and Klapper, W.

Abstract

A subset of patients with advanced-stage classical Hodgkin Lymphoma (cHL) relapse or progress following standard treatment. Given their dismal prognosis, identifying this group of patients upfront represents an important medical need. While prior research has identified characteristics of the tumor microenvironment, which are associated with cHL outcomes, biomarkers that are developed and validated in this high-risk group are still missing. Here, we applied whole-slide image analysis (WSI), a quantitative, large-scale assessment of tumor composition that utilizes conventional histopathology slides. We conducted WSI on a study cohort with pre-treatment biopsies of 340 advanced-stage cHL patients enrolled in the HD12 and HD15 trials of the German Hodgkin Study Group (GHSG), and tested our results in in a validation cohort of 147 advanced-stage cHL patients within the GHSG HD18 trial. All patients were treated with BEACOPP-based regimens. By quantifying T cells, B cells, Hodgkin-Reed-Sternberg-cells and macrophages with WSI, 80% of all cells in the tumor tissue were identified. Crucially, low B cell count was associated with significantly reduced progression-free survival (PFS) and overall survival (OS), while T cell-, macrophage- and Hodgkin-Reed-Sternberg-cell content was not associated with the risk of progression or relapse in the study cohort. We further validated low B cell content as a prognostic factor of PFS and OS in the validation cohort and demonstrate good inter-observer agreement of WSI. WSI may represent a key tool for risk stratification of advanced-stage cHL that can easily be added to the standard diagnostic histopathology work-up.

Published
2020

29. Quality of life in patients with Marfan syndrome: a cross-sectional study of 102 adult patients.

Author

Lehrstuhl für Sportpsychologie, Andonian, C., Freilinger, S. Achenbach, S. Ewert, P. Gundlach, U., Kaemmerer, H., Nadgyman, N., Neidenbach, R.C., Pieper, L., Schelling, J., Weyand, M., & Beckmann, J., Lehrstuhl für Sportpsychologie, and Andonian, C., Freilinger, S. Achenbach, S. Ewert, P. Gundlach, U., Kaemmerer, H., Nadgyman, N., Neidenbach, R.C., Pieper, L., Schelling, J., Weyand, M., & Beckmann, J.

Published
2020

31. Pulmonale Hypertonie bei Erwachsenen mit angeborenen Herzfehlern: Versorgungssituation, Wissensstand und spezifischer Beratungsbedarf

Author

Freilinger, S., Pieper, L., Gundlach, U., Lang, N., Diebold, I., Ewert, P., Kaemmerer, H., and Neidenbach, R.

Subjects
Interdisziplinäre Zusammenarbeit, Erwachsenen mit angeborenen Herzfehlern, ddc: 610, 610 Medical sciences, Medicine, Pulmonale Hypertonie
Abstract

Hintergrund: In Deutschland leben ca. 280.000 Erwachsene mit angeborenen Herzfehlern (EMAH). Der Großteil leidet an Rest- und Folgezuständen und befindet sich nicht in spezialisierter Betreuung. Schätzungen zufolge entwickeln >10% der EMAH eine pulmonale/pulmonalarterielle[zum vollständigen Text gelangen Sie über die oben angegebene URL], 52. Kongress für Allgemeinmedizin und Familienmedizin

Published
2018

34. Medical care of adults with congenital heart diseases Present and future

Author

Neidenbach, R., Achenbach, S., Andonian, C., Beckmann, J., Biber, S., Dittrich, S., Ewert, P., Freilinger, S., Huntgeburth, M., Nagdyman, N., Oberhoffer, R., Pieper, L., von Kodolitsch, Y., Weyand, M., Bauer, U. M. M., Kaemmerer, H., Neidenbach, R., Achenbach, S., Andonian, C., Beckmann, J., Biber, S., Dittrich, S., Ewert, P., Freilinger, S., Huntgeburth, M., Nagdyman, N., Oberhoffer, R., Pieper, L., von Kodolitsch, Y., Weyand, M., Bauer, U. M. M., and Kaemmerer, H.

Abstract

Congenital heart diseases (CHD) are the most common types of congenital organ defects. Thanks to medical progress in congenital cardiology and heart surgery, most children with CHD reach adulthood. Despite primarily successful treatment residual and subsequent conditions as well as (non)cardiac comorbidities can influence the chronic course of the disease and lead to a higher morbidity and mortality. Adults with congenital heart disease (ACHD) in Germany are not tied to the healthcare structure despite the great need for aftercare. According to the results of the medical care of ACHD (MC-ACHD) study, ACHD centers and specialists in Germany are insufficiently perceived despite increased complication rates and the great need for specialist guidance. General practitioners and patients are not adequately informed about existing ACHD facilities. A better awareness of the ACHD problem should be created at the level of primary medical supply in order to optimize care and to reduce morbidity and mortality. Improved future-oriented patient care includes lifelong regular follow-up and the possibility of interdisciplinary, integrated medical care of CHD.

Published
2019

35. Die Versorgungssituation von Erwachsenen mit angeborenen Herzfehlern (EMAH) durch Allgemeinärzte/ Hausärzte und Allgemein-Internisten – aus Sicht der Primärversorger

Author

Sanftenberg, L, Schelling, J, Pieper, L, Tille, T, Venz, J, Seidel, L, Krauß, A, Nagdyman, N, Ewert, P, Kaemmerer, H, and Neidenbach, R

Subjects
chronisch Kranke, ddc: 610, Erwachsene mit angeborenen Herzfehlern, 610 Medical sciences, Medicine, interdisziplinäre Versorgung
Abstract

Hintergrund: Die primär hohe Letalität angeborener Herzfehler (AHF) ist in den letzten Jahrzehnten von >80% auf, 51. Kongress für Allgemeinmedizin und Familienmedizin

Published
2017
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39. Medizinische Versorgung von Erwachsenen mit angeborenen Herzfehlern.

Author

Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, Ewert P, Freilinger S, Huntgeburth M, ·Nagdyman N, Oberhoffer R, Pieper L, von Kodolitsch Y, Weyand M, Bauer UMM, Kaemmerer H and Neidenbach R, Achenbach S, Andonian C, Beckmann J, Biber S, Dittrich S, Ewert P, Freilinger S, Huntgeburth M, ·Nagdyman N, Oberhoffer R, Pieper L, von Kodolitsch Y, Weyand M, Bauer UMM, Kaemmerer H

Published
2018

43. Erwachsene mit angeborenen Herzfehlern: Was der Hausarzt wissen muss

Author

Kaemmerer, H., Achenbach, S., Andonian, C., Beckmann, J., de Haan, F., Diller, G-P., Ewert, P., Freilinger, S., Gundlach, U., Huntgeburth, M., Loßnitzer, D., Nagdyman, N., Pieper, L., Schelling, J., Weyand, M. und Neidenbach, N. and Kaemmerer, H., Achenbach, S., Andonian, C., Beckmann, J., de Haan, F., Diller, G-P., Ewert, P., Freilinger, S., Gundlach, U., Huntgeburth, M., Loßnitzer, D., Nagdyman, N., Pieper, L., Schelling, J., Weyand, M. und Neidenbach, N.

Published
2018

44. Familiäre Hypercholesterinämie in der Primärversorgung in Deutschland. Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment (DETECT)-Studie

Author

Schmidt, N, Schmidt, B, Dressel, A, Fraas, U, Gergei, I, Klotsche, J, Pieper, L, Scharnagl, H, Kleber, M, März, W, Lehnert, H, Pittrow, D, Stalla, G, Wittchen, HU, and Grammer, T

Subjects
ddc: 610, Familiäre Hypercholesterinämie, Prävalenz, DETECT, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die familiäre Hypercholesterinämie (FH) ist eine genetisch bedingte Erhöhung des LDL-Cholesterins; sie erhöht das Risiko von kardiovaskulären Erkrankungen. Dieses Risiko lässt sich durch frühzeitige Diagnose und Therapie signifikant senken. In Deutschland[zum vollständigen Text gelangen Sie über die oben angegebene URL], 50. Kongress für Allgemeinmedizin und Familienmedizin

Published
2016
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45. Veränderungen und Beeinflussbarkeit der Nachsingefähigkeit und der Parameter des Singstimmprofils bei Kindern im Grundschulalter: Ergebnisse einer kontrollierten, randomisierten zweijährigen Follow-up-Studie

Author

Pieper, L, Körner, M, Wiedemann, M, Wagner, F, and Fuchs, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund Über die Nachsingefähigkeit von Kindern im Allgemeinen sowie die Entwicklung der Parameter des Singstimmprofils bei Kindern gibt bis zum aktuellen Zeitpunkt nur spärliche Informationen in der Literatur. Dabei spielen beide für die Erstellung und Beurteilung einer stimmlichen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 33. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP)

Published
2016
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