Search

Your search keyword '"Pieper D"' showing total 1,021 results
Start Over Author "Pieper D"
1,021 results on '"Pieper D"'

3. An algal enzyme required for biosynthesis of the most abundant marine carotenoids

Author

Dautermann, O, Lyska, D, Andersen-Ranberg, J, Becker, M, Fröhlich-Nowoisky, J, Gartmann, H, Krämer, LC, Mayr, K, Pieper, D, Rij, LM, Wipf, HM-L, Niyogi, KK, and Lohr, M

Subjects
Plant Biology, Biological Sciences, Ecology, Algal Proteins, Aquatic Organisms, Carotenoids, Chlorophyll A, Gene Expression Regulation, Light-Harvesting Protein Complexes, Oxidoreductases, Phaeophyceae, Phylogeny, Xanthophylls
Abstract

Fucoxanthin and its derivatives are the main light-harvesting pigments in the photosynthetic apparatus of many chromalveolate algae and represent the most abundant carotenoids in the world's oceans, thus being major facilitators of marine primary production. A central step in fucoxanthin biosynthesis that has been elusive so far is the conversion of violaxanthin to neoxanthin. Here, we show that in chromalveolates, this reaction is catalyzed by violaxanthin de-epoxidase-like (VDL) proteins and that VDL is also involved in the formation of other light-harvesting carotenoids such as peridinin or vaucheriaxanthin. VDL is closely related to the photoprotective enzyme violaxanthin de-epoxidase that operates in plants and most algae, revealing that in major phyla of marine algae, an ancient gene duplication triggered the evolution of carotenoid functions beyond photoprotection toward light harvesting.

Published
2020

7. Interrupted Time Series for Assessing the Causality of Intervention Effects.

Author

Mathes, T., Röding, D., Stegbauer, C., Laxy, M., and Pieper, D.

Abstract

Background: The gold standard for evaluating interventions in medicine and health care is the randomized controlled trial (RCT). In practice, however, RCTs may be difficult to conduct because of high costs, ethical aspects, or practical considerations. This is particularly true of studies on the population level, e.g., for the evaluation of health policy measures. Methods: We present a type of study design called the interrupted time series (ITS) and its critical interpretation, with several illustrative examples. This discussion is based on selected methodological publications. Results: ITS are suitable for the assessment of interventions with a clear point of intervention (interruption). They are analyzed with the statistical methods of time-series analysis. One strength of ITS is that they can be used to estimate an immediate effect as well as a gradually developing effect. Under certain assumptions, the findings of an ITS analysis can be interpreted causally. The main assumption underlying an ITS is that the trend after the intervention would have been exactly the same as the trend before the intervention if the intervention had not taken place and all other conditions had remained unchanged. A further assumption is that there should be no differences in the pre- versus postintervention phases in the subjects or other entities being tested (e.g., hospitals) that might affect the measured endpoints (e.g., differences in mean age affecting measured mortality). Moreover, the intervention periods must be properly distinct from one another in order to prevent biased effect estimates. The robustness of the assumptions should also be checked with sensitivity analyses. Conclusion: As long as all sources of bias have been avoided and the findings are both plausible and robust, the effects revealed by ITS can be interpreted as causal. ITS may serve as an alternative method for evaluating intervention effects when an RCT cannot be performed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Was wird unter einer Public-Health-Intervention verstanden? Ergebnisse eines Delphi-Prozesses im deutschsprachigen Raum - ein Projekt des Fachbereichs Public Health

Author

Dieudonné, J, Jantzen, L, Sanwald, M, Trompke, M, Stegbauer, C, Pieper, D, Willms, G, Buchberger, B, Büchter, RB, Bühn, S, Fischer, F, Klein, K, Kuhn, J, Messer, M, Wegewitz, U, Niederberger, M, Dieudonné, J, Jantzen, L, Sanwald, M, Trompke, M, Stegbauer, C, Pieper, D, Willms, G, Buchberger, B, Büchter, RB, Bühn, S, Fischer, F, Klein, K, Kuhn, J, Messer, M, Wegewitz, U, and Niederberger, M

Published
2024

29. Development and testing of a tool to foster shared decision-making between patients and healthcare professionals in clinical practice guidelines

Author

Fischer, L, Scheibler, F, Schaefer, C, Karge, T, Langer, T, Schewe, LV, Florez, ID, Li, S, Maes-Carballo, M, Munn, Z, Perestelo-Perez, L, Puljak, L, Stiggelbout, A, Pieper, D, Fischer, L, Scheibler, F, Schaefer, C, Karge, T, Langer, T, Schewe, LV, Florez, ID, Li, S, Maes-Carballo, M, Munn, Z, Perestelo-Perez, L, Puljak, L, Stiggelbout, A, and Pieper, D

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results