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Your search keyword '"Pierdomenico, Sante D."' showing total 378 results
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378 results on '"Pierdomenico, Sante D."'

4. Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration.

Author

Diomede, Francesca, Guarnieri, Simone, Lanuti, Paola, Konstantinidou, Fani, Gatta, Valentina, Rajan, Thangavelu Soundara, Pierdomenico, Sante D., Trubiani, Oriana, Marconi, Guya Diletta, and Pizzicannella, Jacopo

Subjects
EXTRACELLULAR vesicles, PERIPHERAL vascular diseases, MESENCHYMAL stem cells, GENE expression, DENTAL pulp, HEART
Abstract

Mesenchymal stem cells (MSCs) treatment has been widely explored as a therapy for myocardial infarction, peripheral ischemic vascular diseases, dilated cardiomyopathy, and pulmonary hypertension. Latest in vitro studies suggest that MSCs can differentiate into contractile cardiomyocytes. One of the best‐characterized MSCs products are MSCs‐derived extracellular vesicles (EVs). EVs are crucial paracrine effectors of MSCs. Based on previous works, paracrine effects of MSCs play a primary role in the regenerative ability. Hence, in the current paper, we focused our attention on an alternative approach, exploiting products derived from human dental pulp stem cells (hDPSCs) rather than MSCs themselves, which may denote a cost‐effective and safer approach. The focus has been on EVs and the bioactive molecules they contain to evaluate their ability to influence the differentiation process toward cardiomyogenic lineage. The expression of GATA4, ACTC1, CX43, and Nkx2.5 was evaluated using Immunofluorescence, real time‐PCR, and Western blotting analyses. Furthermore, the expression profiling analysis of the microRNA hsa‐miR‐200c‐3p, targeting the GATA4 gene, was studied. The hsa‐miR‐200c‐3p was found significantly down‐regulated in both c‐hDPSCs + EVs‐hDPSCs and c‐hDPSCs + EVs‐HL‐1 compared to untreated c‐hDPSCs underlying a possible epigenetic mechanism behind the prevalent up‐regulation of its targeted GATA4 gene. The aim of the present work was to develop an in vitro model of hDPSCs able to differentiate into cardiomyocytes in order to investigate the role of EVs derived from hDPSCs and derived from HL‐1 cardiomyocyte cell line in modulating the differentiation process toward cardiomyogenic lineage. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring

Author

Coccina, Francesca, primary, Borrelli, Paola, additional, Pierdomenico, Anna M., additional, Pizzicannella, Jacopo, additional, Guagnano, Maria T., additional, Cuccurullo, Chiara, additional, Di Nicola, Marta, additional, Renda, Giulia, additional, Trubiani, Oriana, additional, Cipollone, Francesco, additional, and Pierdomenico, Sante D., additional

Published
2022
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16. Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH SOLUTION): proposal of a study protocol aimed to realize a validated risk score for early diagnosis

Author

MIOTTI, Cristiano, primary, D’ARMINI, Andrea M., additional, SCARDOVI, Beatrice, additional, GHIO, Stefano, additional, SINAGRA, Gianfranco, additional, SERRA, Walter, additional, ROMANIELLO, Antonella, additional, GALGANO, Giuseppe, additional, RONCON, Loris, additional, D’ALTO, Michele, additional, GIANNAZZO, Daniela, additional, VITULO, Patrizio, additional, BONGARZONI, Amedeo, additional, RUZZOLINI, Matteo, additional, ALBERA, Carlo, additional, CASU, Gavino, additional, PERAZZOLO MARRA, Martina, additional, PIERDOMENICO, Sante D., additional, LUONGO, Federico, additional, MANZI, Giovanna, additional, PAPA, Silvia, additional, SCOCCIA, Gianmarco, additional, CEDRONE, Nadia, additional, BADAGLIACCA, Roberto, additional, and VIZZA, Carmine D., additional

Published
2022
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32. Blood pressure variability and prognosis in uncomplicated mild hypertension

Author

Pierdomenico, Sante D., Lapenna, Domenico, Bucci, Anna, Manente, Bianca M., Mancini, Mariantoniette, Cuccurullo, Franco, and Mzzetti, Andrea

Subjects
Cardiovascular diseases -- Causes of, Cardiovascular diseases -- Research, Hypertension -- Research, Blood pressure -- Research, Health
Published
2005

35. Risk of Atrial Fibrillation in Masked and White Coat Uncontrolled Hypertension

Author

Coccina, Francesca, primary, Pierdomenico, Anna M, additional, De Rosa, Matteo, additional, Lorenzo, Belli, additional, Foglietta, Melissa, additional, Petrilli, Ivan, additional, Vitulli, Piergiusto, additional, Pizzicannella, Jacopo, additional, Trubiani, Oriana, additional, Cipollone, Francesco, additional, Renda, Giulia, additional, and Pierdomenico, Sante D, additional

Published
2020
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40. Association of Extreme Nocturnal Dipping With Cardiovascular Events Strongly Depends on Age

Author

Palatini, Paolo, primary, Verdecchia, Paolo, additional, Beilin, Lawrence J., additional, Eguchi, Kazuo, additional, Imai, Yutaka, additional, Kario, Kazuomi, additional, Ohkubo, Takayoshi, additional, Pierdomenico, Sante D., additional, Saladini, Francesca, additional, Schwartz, Joseph E., additional, Wing, Lindon, additional, Signorotti, Sara, additional, and Reboldi, Gianpaolo, additional

Published
2020
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43. Demographic and Lifestyle Factors and Memory in European Older People

Author

Steffl, Michal, Jandova, Tereza, Dadova, Klara, Holmerova, Iva, Vitulli, Piergiusto, Pierdomenico, Sante D., and Pietrangelo, Tiziana

Subjects
Male, genetic structures, Alcohol Drinking, Middle Aged, word-list learning test, Article, memory, Europe, Cross-Sectional Studies, demographic and lifestyle factors, ageing, Mental Recall, Humans, Female, Life Style, Aged
Abstract

Objectives: To investigate associations between demographic and lifestyle factors and memory performance in European people aged &ge, 60 years. Methods: Data from 23,641 people with a mean age of 70.2 (95 % CI 70.1&ndash, 70.3) were analyzed and drawn from the fourth wave of the Survey of Health, Ageing, and Retirement in Europe (SHARE). Generalized linear models were carried out to estimate the associations for both men and women. Memory performance was tested using two word-list learning tests with immediate and delayed recall in SHARE. Results: age, severe limitations in physical activities, and any past alcohol problem were all negatively associated with memory performance. Contrarily, education level, higher nonalcoholic fluid intake, and engagement in sports activities more than once a week and in activities requiring a moderate level of energy were all positively associated with memory performance. Smoking showed a significant negative association only in the immediate recall test for both men and women together, whilst long-term illness showed association only in the delayed recall. Alcohol consumption was positively associated with memory performance in women, but in men, it depended on the drinking frequency. Conclusions: Demographic and lifestyle factors are associated with memory performance in the older population.

Published
2019

48. Atrial Cardiopathy and Hypertension: A Deadly Association.

Author

Pierdomenico, Sante D and Coccina, Francesca

Subjects
LEFT ventricular hypertrophy, CARDIAC magnetic resonance imaging
Abstract

Atrial cardiopathy, encompassing chamber enlargement, wall structural changes, electrical remodeling, functional impairment, and prothrombotic predisposition,[[1], [3]] may be detected in individuals in the general population, including those with normotension and hypertension. The individuals with concomitant atrial cardiopathy and elevated, stage 1 or 2 hypertension also had higher cardiovascular mortality rates (22.3, 25.7, and 33.9 per 1,000 person-years, respectively) compared with their counterparts in the same hypertension categories without atrial cardiopathy (7.8, 8.1, and 17.8 per 1,000 person-years, respectively). All-cause death rates were almost double among subjects with concomitant atrial cardiopathy and elevated blood pressure (120-129/<80), stage 1 (130-139/80-89) or stage 2 hypertension (>=140/>=90) compared with their counterparts in the same hypertension stages without atrial cardiopathy (47.8, 61.3, and 80.2 vs. 23, 24.7, and 44.8 per 1,000 person-years, respectively). [Extracted from the article]

Published
2023
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