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1. Hematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients

Author

Costa, Thalita Cristina de Mello, Chiari-Correia, Rodolfo, Salmon, Carlos Ernesto G., Darrigo-Junior, Luiz Guilherme, Grecco, Carlos Eduardo S., Pieroni, Fabiano, Faria, Joana Teresa B., Stracieri, Ana Beatriz P. L., Dias, Juliana B. E., de Moraes, Daniela Aparecida, Oliveira, Maria Carolina, Guerino-Cunha, Renato, Santos, Antônio Carlos, and Simões, Belinda P.

Published
2021
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2. HLA-identical sibling hematopoietic stem cell transplantation following reduced-toxicity myeloablative conditioning regimen in sickle cell disease

Author

Costa, Thalita, primary, Darrigo-Junior, Luiz, additional, Grecco, Carlos, additional, Pieroni, Fabiano, additional, Faria, Joana, additional, Stracieri, Ana Beatriz, additional, Dias, Juliana, additional, Vieira, Ana Carolina, additional, Mesquita, Camila, additional, Laurindo, Patrícia, additional, Pires, Bruno, additional, Valeri, Pedro, additional, Silva, Gabriela, additional, Moraes, Daniela, additional, Loterio, Lucas, additional, Oliveira-Cardoso, Érika, additional, Santos, Manoel Antônio dos, additional, Santos, Flávia, additional, Pinto, Ana Cristina, additional, Guerino-Cunha, Renato, additional, Oliveira, Maria Carolina, additional, Traina, Fabiola, additional, Santos, Antonio, additional, De Santis, Gil, additional, and Simões, Belinda, additional

Published
2023
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3. Cryopreservation Impairs Engraftment in Bone Marrow Transplantation

Author

Costa, Thalita Cristina De Cristina de Mello, primary, Donadel, Camila Derminio, additional, Siqueira, Thais Helena R., additional, André, Nathália Cristine, additional, Darrigo, Luiz Guilherme, additional, Pieroni, Fabiano, additional, Dias, Juliana Bernardes Elias, additional, Stracieri, Ana Beatriz Pereira Lima, additional, Grecco, Carlos Eduardo Setanni, additional, Faria, Joana T B, additional, Vieira, Ana Carolina de Jesus, additional, Mesquita, Camila Campos, additional, Silva, Bruno Garcia Peixoto Pires da, additional, Laurindo, Patrícia da Silva, additional, Valeri, Pedro Augusto de Oliveira, additional, Moraes, Daniela Aparecida de, additional, Ventura, Gabriela, additional, Oliveira, Maria Carolina, additional, Guerino-Cunha, Renato Luiz, additional, and De Santis, Gil Cunha, additional

Published
2022
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4. Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients

Author

Jarduli‐Maciel, Luciana Ribeiro, primary, de Azevedo, Júlia Teixeira Cottas, additional, Clave, Emmanuel, additional, Costa, Thalita Cristina de Mello, additional, Arruda, Lucas Coelho Marlière, additional, Fournier, Isabelle, additional, Palma, Patrícia Vianna Bonini, additional, Lima, Keli Cristina, additional, Elias, Juliana Bernardes, additional, Stracieri, Ana Beatriz PL, additional, Pieroni, Fabiano, additional, Cunha, Renato, additional, Darrigo‐Júnior, Luiz Guilherme, additional, Grecco, Carlos Eduardo Settani, additional, Covas, Dimas Tadeu, additional, Silva‐Pinto, Ana Cristina, additional, De Santis, Gil Cunha, additional, Simões, Belinda Pinto, additional, Oliveira, Maria Carolina, additional, Toubert, Antoine, additional, and Malmegrim, Kelen Cristina Ribeiro, additional

Published
2022
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5. Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients

Author

de Azevedo, Júlia Teixeira Cottas, primary, Costa, Thalita Cristina de Mello, additional, Lima, Keli Cristina, additional, Maciel, Thiago Trovati, additional, Palma, Patrícia Vianna Bonini, additional, Darrigo-Júnior, Luiz Guilherme, additional, Setanni Grecco, Carlos Eduardo, additional, Stracieri, Ana Beatriz P. L., additional, Elias, Juliana Bernardes, additional, Pieroni, Fabiano, additional, Guerino-Cunha, Renato Luiz, additional, Pinto, Ana Cristina Silva, additional, De Santis, Gil Cunha, additional, Covas, Dimas Tadeu, additional, Hermine, Olivier, additional, Simões, Belinda Pinto, additional, Oliveira, Maria Carolina, additional, and Malmegrim, Kelen Cristina Ribeiro, additional

Published
2021
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6. Viability of Chimeric Antigen Receptor T Cell Therapy in Latin America

Author

Guerino-Cunha, Renato L, primary, Clé, Diego, additional, Palma, Leonardo Carvalho, additional, Donadel, Camila Dermínio, additional, Oliveira, Lucas, additional, Terra, Patricia Oliveira da Cunha, additional, Costa, Thalita Cristina de Mello, additional, Dias, Juliana Bernardes Elias, additional, Pieroni, Fabiano, additional, Stracieri, Ana Beatriz Pereira Lima, additional, Silveira, Caio Raony Farina, additional, Puga, Marcelo Lourencini, additional, Martins, Amanda Mizukami, additional, Caruso, Sâmia Rigotto, additional, Souza, Lucas Eduardo Botelho, additional, Fantacini, Daianne Maciely Carvalho, additional, Barboza, Leticia Maria Defendi, additional, Giuberti, Maria Fernanda Lima, additional, Pereira, Gabriel Carvalho, additional, Fernandes, Taisa Risque, additional, Bolzoni, Rosane Maria Falasco, additional, Vieira, Ana Carolina Jesus, additional, Palma, Patrícia Vianna Bonini, additional, Basile, Anibal, additional, Chahud, Fernando, additional, Prado, Benedito Pina Almeida, additional, Orellana, Maristela Delgado, additional, De Santis, Gil Cunha, additional, Rego, Eduardo M, additional, Calado, Rodrigo T., additional, and Covas, Dimas T., additional

Published
2021
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8. C-Peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

Author

Couri, Carlos A.B., Oliveira, Maria C.B., Stracieri, Ana B.P.L., Moraes, Daniela A., Pieroni, Fabiano, Barros, George M.N., Madeira, Maria Isabel A., Malmegrim, Kelen C.R., Foss-Freitas, Maria C., Simoes, Belinda P., Martinez, Edson Z., Foss, Milton C., Burt, Richard K., and Voltarelli, Julio C.

Subjects
Type 1 diabetes -- Diagnosis, C-reactive protein -- Measurement, Hematopoietic stem cells -- Transplantation, Hematopoietic stem cells -- Usage, Hematopoietic stem cells -- Health aspects
Abstract

The study attempts to evaluate the C-Peptide levels after autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) among newly diagnosed type 1 diabetes mellitus. The results indicate that C-Peptide levels increased significantly following HSCT and patients exhibited insulin independence with good glycemic control.

Published
2009

9. Clinical studies using stem cells for treatment of retinal diseases: state of the art

Author

Cotrim, Carina Costa, Jorge, Rodrigo, Oliveira, Maria Carolina de, Pieroni, Fabiano, Messias, André M. Vieira, and Siqueira, Rubens Camargo

Subjects
Células-tronco embrionárias, Embryonic stem cells, Induced pluripotent stem cells, genetic structures, Células-tronco pluripotentes induzidas, Células progenitoras da retina, sense organs, Stem cells, Retinal progenitor cells, Células-tronco, eye diseases, Bone marrow-derived stem cells, Células-tronco derivadas da medula óssea
Abstract

Degenerative retinal diseases such as retinitis pigmentosa, Stargardt’s macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them. RESUMO As doenças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizadas por perda irre versível da visão devido a danos diretos ou indiretos aos fotorreceptores. Não existem tratamentos eficazes, porém os estudos com células-tronco mostraram resultados promissores. Nosso objetivo com esta revisão foi descrever os tipos de células-tronco em estudo, seus efeitos e os principais ensaios clínicos que as envolvem.

Published
2020

10. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

Author

Voltarelli, Julio C., Couri, Carlos E.B., Stracieri, Ana B.P.L., Oliveira, Maria C., Moraes, Daniela A., Pieroni, Fabiano, Coutinho, Marina, Malmegrim, Kelen C.R., Foss-Freitas, Maria C., Simoes, Belinda P., Foss, Milton C., Squiers, Elizabeth, and Burt, Richard K.

Subjects
Type 1 diabetes -- Diagnosis, Type 1 diabetes -- Drug therapy, Hematopoietic stem cells -- Transplantation, Hematopoietic stem cells -- Health aspects, Hematopoietic stem cells -- Patient outcomes
Abstract

The safety and metabolic effects of high-dose immunosuppression were determined, followed by autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) in newly diagnosed type 1 diabetes mellitus (DM). With AHST, beta cell function was found to be increased in all but 1 patient and induced prolonged insulin independence in the majority of the patients.

Published
2007

12. Blood transfusion support for sickle cell patients during haematopoietic stem cell transplantation: a single‐institution experience

Author

De Santis, Gil C., primary, Costa, Thalita C. M., additional, Santos, Flávia L. S., additional, Silva‐Pinto, Ana C., additional, Stracieri, Ana B. P. L., additional, Pieroni, Fabiano, additional, Darrigo‐Júnior, Luiz G., additional, Faria, Joana T. B., additional, Grecco, Carlos E. S., additional, Moraes, Daniela A., additional, Elias Dias, Juliana B., additional, Oliveira, Maria C., additional, Covas, Dimas T., additional, Cunha, Renato, additional, and Simões, Belinda P., additional

Published
2020
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16. Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

Author

Malmegrim, Kelen C. R., primary, de Azevedo, Júlia T. C., additional, Arruda, Lucas C. M., additional, Abreu, Joana R. F., additional, Couri, Carlos E. B., additional, de Oliveira, Gislane L. V., additional, Palma, Patricia V. B., additional, Scortegagna, Gabriela T., additional, Stracieri, Ana B. P. L., additional, Moraes, Daniela A., additional, Dias, Juliana B. E., additional, Pieroni, Fabiano, additional, Cunha, Renato, additional, Guilherme, Luiza, additional, Santos, Nathália M., additional, Foss, Milton C., additional, Covas, Dimas T., additional, Burt, Richard K., additional, Simões, Belinda P., additional, Voltarelli, Júlio C., additional, Roep, Bart O., additional, and Oliveira, Maria C., additional

Published
2017
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17. Allogenic bone narrow transplantation in sickle-cell diseases.

Author

Simões, Belinda Pinto, primary, Pieroni, Fabiano, additional, Costa, Thalita, additional, Barros, George Navarro, additional, Darrigo Jr., Guilherme, additional, Grecco, Carlos Settani, additional, Bernardes, Juliana Elias, additional, Moraes, Daniela, additional, Stracieri, Ana Beatriz Lima, additional, Cunha, Renato, additional, and Rodrigues, Maria Carolina, additional

Published
2016
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18. Terapia celular no diabetes mellitus

Author

Voltarelli, Julio C., Couri, Carlos E. B., Rodrigues, Maria Carolina, Moraes, Daniela A., Stracieri, Ana Beatriz P. L., Pieroni, Fabiano, Navarro, George, Madeira, Maria Isabel A., and Simões, Belinda P.

Subjects
medula óssea, Diabetes mellitus, bone marrow, autologous stem cell transplantation, stem cells, células-tronco, cord blood, Diabete melito, embrionárias, embryonic, cordão umbilical, transplante autólogo de células-tronco hematopoéticas
Abstract

Nesta revisão são discutidas várias alternativas de regeneração do conjunto de células produtoras de insulina do pâncreas, usando células-tronco embrionárias do cordão umbilical e adultas, e o trabalho que está sendo realizado em nosso grupo de pesquisas utilizando imunossupressão em altas doses combinada com a infusão de células-tronco hematopoéticas autólogas em diabete do tipo 1 recém-diagnosticado. In this review, we discuss several alternatives for the regeneration of the pool of insulin-producing cells by the pancreas using embryonic, cord blood or adult stem cells and the work being carried out by our research group using high dose immunosuppression with autologous hematopoietic stem cells in newly diagnosed type 1 diabetes mellitus.

Published
2009

19. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras

Author

Voltarelli,Júlio C., Stracieri,Ana Beatriz P. L., Oliveira,Maria Carolina B., Godoi,Dannielle F., Moraes,Daniela A., Pieroni,Fabiano, Malmegrim,Kelen C. R., Coutinho,Marina A., Simões,Belinda P., Massumoto,Celso, Hamerschlak,Nelson, Scheinberg,Morton, Ferreira,Eurípides, Coutinho,Mariana, Ostronoff,Maurício, Sturaro,Daniel, and Dulley,Frederico

Subjects
doenças reumáticas, transplante de medula óssea, células-tronco hematopoéticas
Abstract

Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto; entre os 7 de esclerose sistêmica, houve 3 remissões após o TCTH e 2 após mobilização, um óbito pós-mobilização das CTH e outro após a primeira dose do condicionamento, este último em uma superposição com LES; em dois pacientes com vasculite, houve uma remissão em arterite de Takayasu e outra em doença de Behçet; uma paciente com artrite inflamatória juvenil foi incluída muito recentemente no protocolo. O seguimento dos pacientes sobreviventes variou de 0 a 48 meses, com uma mediana de 29 meses. Conclui-se com uma discussão do custo-benefício do TCTH em face das novas formas de imunossupressão disponíveis e das perspectivas futuras em países desenvolvidos, onde se iniciaram recentemente estudos prospectivos randomizados comparando o transplante com a melhor terapia medicamentosa disponível, e no Brasil, onde o custo do transplante é muito inferior ao das novas terapias biológicas.

Published
2005

20. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras

Author

Voltarelli, Júlio C., Stracieri, Ana Beatriz P. L., Oliveira, Maria Carolina B., Godoi, Dannielle F., Moraes, Daniela A., Pieroni, Fabiano, Malmegrim, Kelen C. R., Coutinho, Marina A., Simões, Belinda P., Massumoto, Celso, Hamerschlak, Nelson, Scheinberg, Morton, Ferreira, Eurípides, Coutinho, Mariana, Ostronoff, Maurício, Sturaro, Daniel, and Dulley, Frederico

Subjects
bone marrow transplantation, rheumatic diseases, doenças reumáticas, transplante de medula óssea, células-tronco hematopoéticas, hematopoietic stem cells
Abstract

Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto; entre os 7 de esclerose sistêmica, houve 3 remissões após o TCTH e 2 após mobilização, um óbito pós-mobilização das CTH e outro após a primeira dose do condicionamento, este último em uma superposição com LES; em dois pacientes com vasculite, houve uma remissão em arterite de Takayasu e outra em doença de Behçet; uma paciente com artrite inflamatória juvenil foi incluída muito recentemente no protocolo. O seguimento dos pacientes sobreviventes variou de 0 a 48 meses, com uma mediana de 29 meses. Conclui-se com uma discussão do custo-benefício do TCTH em face das novas formas de imunossupressão disponíveis e das perspectivas futuras em países desenvolvidos, onde se iniciaram recentemente estudos prospectivos randomizados comparando o transplante com a melhor terapia medicamentosa disponível, e no Brasil, onde o custo do transplante é muito inferior ao das novas terapias biológicas. In this review, we discuss the results of hematopoietic stem cell transplantation (HSCT) for severe and refractory rheumatic diseases performed in Brazil. We analyze preliminary results obtained in Brazil with autologous HSCT in anecdotal cases (N = 3) and in the cooperative protocol initiated in 2001 (N = 18). In 8 lupus nephritis patients there were 3 sustained remissions, 3 deaths, 1 mobilisation failure and 1 short follow-up; in 7 systemic sclerosis patients there were 3 sustained remissions after transplantation and 2 after mobilisation, 1 death before mobilisation and another after the first dose of the conditioning in an overlapping syndrome of SLE and SSc, and between 2 patients with vasculitis there was 1 sustained remission in Takayasu's arteritis and another in Behçet's disease. One patient with juvenile idiopathic arthritis was included in the protocol very recently. The follow-up of the patients varied from 0 to 48 months with a median of 29 months. We conclude the study with a discussion of future prospectives in developed countries, where randomized trials comparing transplantation with the best pharmacological therapy available have started recently, and in Brazil, where several adaptations of existing protocols are required and the cost of transplantation is much lower than that of new biological therapies.

Published
2005

21. Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis

Author

Sousa, Alessandra de Paula A., primary, Malmegrim, Kelen C. R., additional, Panepucci, Rodrigo A., additional, Brum, Doralina S., additional, Barreira, Amilton A., additional, Carlos Dos Santos, Antonio, additional, Araújo, Amélia G., additional, Covas, Dimas Tadeu, additional, Oliveira, Maria C., additional, Moraes, Daniela A., additional, Pieroni, Fabiano, additional, Barros, George M., additional, Simões, Belinda P., additional, Nicholas, Richard, additional, Burt, Richard K., additional, Voltarelli, Júlio C., additional, and Muraro, Paolo A., additional

Published
2014
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22. Allogeneic Stem Cell Transplantation for Sickle Cell Disease in Brazil: The Time Is Now!

Author

Simoes, Belinda Pinto, primary, Navarro, George B, additional, Pieroni, Fabiano, additional, Darrigo, Luiz G, additional, Moraes, Daniela, additional, Stracieri, Ana Beatriz PL, additional, Fernandes, Juliana F, additional, Bonfim, Carmem, additional, Teixeira, Gustavo Machado, additional, Aranha, Francisco J P, additional, and Voltarelli, Júlio C., additional

Published
2011
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23. Stem cell therapy for diabetes mellitus

Author

Voltarelli, Júlio C., primary, Couri, Carlos E.B., additional, Oliveira, Maria C., additional, Moraes, Daniela A., additional, Stracieri, Ana B.P.L., additional, Pieroni, Fabiano, additional, Barros, George M.N., additional, Malmegrim, Kelen C.R., additional, Simões, Belinda P., additional, Leal, Angela M.O., additional, and Foss, Milton C., additional

Published
2011
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25. Terapia celular no diabetes mellitus

Author

Voltarelli, Julio C., primary, Couri, Carlos E. B., additional, Rodrigues, Maria Carolina, additional, Moraes, Daniela A., additional, Stracieri, Ana Beatriz P. L., additional, Pieroni, Fabiano, additional, Navarro, George, additional, Madeira, Maria Isabel A., additional, and Simões, Belinda P., additional

Published
2009
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28. Autologous Hematopoietic Stem Cell Transplantation in Severe Multiple Sclerosis. The Brazilian Experience with Two Conditioning Regimes: BEAM and High-Dose Cyclophosphamide.

Author

Voltarelli, Julio C, primary, Coutinho, Marina A., additional, Stracieri, Ana Beatriz P.L., additional, Oliveira, Maria Carolina B., additional, Moraes, Daniela A., additional, Pieroni, Fabiano, additional, Simoes, Belinda P., additional, Barros, George M.N., additional, Ribeiro, Amilton F., additional, Hamerschlak, Nelson, additional, Leite, Cesar, additional, and Zanis, Jose, additional

Published
2007
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30. Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis.

Author

de Paula A. Sousa, Alessandra, Malmegrim, Kelen C. R., Panepucci, Rodrigo A., Brum, Doralina S., Barreira, Amilton A., Dos Santos, Antonio Carlos, Araújo, Amélia G., Covas, Dimas Tadeu, Oliveira, Maria C., Moraes, Daniela A., Pieroni, Fabiano, Barros, George M., Simões, Belinda P., Nicholas, Richard, Burt, Richard K., Voltarelli, Júlio C., and Muraro, Paolo A.

Subjects
MULTIPLE sclerosis treatment, HEMATOPOIETIC stem cell transplantation, IMMUNE system, GENE expression, AUTOTRANSPLANTATION, CD8 antigen, CD4 antigen, GENETICS, THERAPEUTICS
Abstract

Autologous haematopoietic stem-cell transplantation (AHSCT) has been experimented as a treatment in patients affected by severe forms of multiple sclerosis (MS) who failed to respond to standard immunotherapy. The rationale of AHSCT is to 'reboot' the immune system and reconstitute a new adaptive immunity. The aim of our study was to identify, through a robust and unbiased transcriptomic analysis, any changes of gene expression in T-cells potentially underlying the treatment effect in patients who underwent non-myeloablative AHSCT for treatment of MS. We evaluated by microarray DNA-chip technology the gene expression of peripheral CD4+ and CD8+ T-cell subsets sorted from patients with MS patients before AHSCT, at 6 months, 1 year and 2 years after AHSCT and from healthy control subjects. Hierarchical clustering analysis revealed that reconstituted CD8+ T-cells of MS patients at 2 years post-transplantation, aggregated together with healthy controls, suggesting a normalization of gene expression in CD8+ cells post-therapy. When we compared the gene expression in MS patients before and after therapy, we detected a large number of differentially expressed genes (DEG) in both CD8+ and CD4+ T-cell subsets at all time points after transplantation. We catalogued the biological function of DEG and we selected 27 genes known to be involved in immune function for accurate quantification of gene expression by real-time PCR. The analysis confirmed and extended with quantitative data, a number of significant changes in both the CD4+ and CD8+ T-cells subsets from MS post-transplant. Notably, CD8+ T-cells revealed more extensive changes in the expression of genes involved in effector immune responses. [ABSTRACT FROM AUTHOR]

Published
2015
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31. Mobilization, Collection, Infusion and Granulocyte Recovery of PBSC in Type 1 Diabets Mellitus Pacients after High Dose Immunosupression.

Author

Prata, Karen L., primary, De Santis, Gil C., additional, Oliveira, Maria Carolina B., additional, Moraes, Daniela A., additional, Júnior, Benedito P.A. Prado, additional, Orellana, Maristela D., additional, Palma, Patricia V.B., additional, Stracieri, Ana Beatriz P.L., additional, Pieroni, Fabiano, additional, Coutinho, Marina A., additional, Simões, Belinda P., additional, Covas, Dimas T., additional, and Voltarelli, Júlio C., additional

Published
2006
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33. Fludarabine and Oral Busulfan: A Low Toxicity Conditioning Regimen When Plasma Level Targeting and Intravenous Busulfan Is Not Available. A Brazilian Experience.

Author

Simoes, Belinda P., primary, Souza, M., primary, Mauad, Marcos, primary, Paton, Eduardo J.A., primary, Pieroni, Fabiano, primary, Stracieri, Ana B.P.L., primary, Oliveira, Maria C., primary, Moraes, Daniela, primary, Coutinho, Marina, primary, Voltarelli, Julio C., primary, and Colturato, Vergilio R., primary

Published
2005
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35. USE OF THERAPEUTIC LASER FOR PREVENTION AND TREATMENT OF ORAL MUCOSITIS.

Author

Khouri, Vivian Youssef, Stracieri, Ana Beatriz Pereira Lima, Rodrigues, Maria Carolina, de Moraes, Daniela Aparecida, Pieroni, Fabiano, Simões, Belinda Pinto, and Voltarelli, Júlio César

Subjects
*LASER therapy, *ORAL mucosa diseases, *HEMATOPOIETIC stem cell transplantation, *DENTAL radiography, *RADIOTHERAPY complications, *DENTAL pathology, *DRUG side effects, *MOUTHWASHES, *GRAFT versus host disease, *COMPARATIVE studies, *PATIENTS, *THERAPEUTICS
Abstract

Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called "Mucositis Formula"). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/ cm² dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM. [ABSTRACT FROM AUTHOR]

Published
2009

36. Stem cell therapies for type 1 diabetes mellitus.

Author

Voltarelli JC, Couri CE, Rodrigues MC, Moraes DA, Stracieri AB, Pieroni F, Navarro G, Leal AM, and Simões BP

Subjects
Animals, Cord Blood Stem Cell Transplantation, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 immunology, Embryonic Stem Cells transplantation, Hematologic Diseases complications, Hematologic Diseases therapy, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppression Therapy, Insulin-Secreting Cells transplantation, Mesenchymal Stem Cell Transplantation, Mice, Transplantation, Autologous, Diabetes Mellitus, Type 1 therapy, Stem Cell Transplantation
Abstract

The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.

Published
2011

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