174 results on '"Pierre Mallet"'
Search Results
2. Mask side-effects are related to gender in long-term CPAP: results from the InterfaceVent real-life study
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Celia Vidal, Fanny Bertelli, Jean-Pierre Mallet, Raphael Gilson, Jean-Christian Borel, Frédéric Gagnadoux, Arnaud Bourdin, Nicolas Molinari, and Dany Jaffuel
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Sleep apnea ,Leaks ,Side-effects ,Women ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Over the past three decades, our understanding of sleep apnea in women has advanced, revealing disparities in pathophysiology, diagnosis, and treatment compared to men. However, no real-life study to date has explored the relationship between mask-related side effects (MRSEs) and gender in the context of long-term CPAP. Methods The InterfaceVent-CPAP study is a prospective real-life cross-sectional study conducted in an apneic adult cohort undergoing at least 3 months of CPAP with unrestricted mask-access (34 different masks, no gender specific mask series). MRSE were assessed by the patient using visual analog scales (VAS). CPAP-non-adherence was defined as a mean CPAP-usage of less than 4 h per day. The primary objective of this ancillary study was to investigate the impact of gender on the prevalence of MRSEs reported by the patient. Secondary analyses assessed the impact of MRSEs on CPAP-usage and CPAP-non-adherence depending on the gender. Results A total of 1484 patients treated for a median duration of 4.4 years (IQ25–75: 2.0–9.7) were included in the cohort, with women accounting for 27.8%. The prevalence of patient-reported mask injury, defined as a VAS score ≥ 5 (p = 0.021), was higher in women than in men (9.6% versus 5.3%). For nasal pillow masks, the median MRSE VAS score for dry mouth was higher in women (p = 0.039). For oronasal masks, the median MRSE VAS score for runny nose was higher in men (p = 0.039). Multivariable regression analyses revealed that, for both women and men, dry mouth was independently and negatively associated with CPAP-usage, and positively associated with CPAP-non-adherence. Conclusion In real-life patients treated with long-term CPAP, there are gender differences in patient reported MRSEs. In the context of personalized medicine, these results suggest that the design of future masks should consider these gender differences if masks specifically for women are developed. However, only dry mouth, a side effect not related to mask design, impacts CPAP-usage and non-adherence. Trial Registration: InterfaceVent is registered with ClinicalTrials.gov (NCT03013283).First registration date is 2016–12-23.
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- 2024
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3. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia
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Lloyd A. C. Chapman, Maite Aubry, Noémie Maset, Timothy W. Russell, Edward S. Knock, John A. Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam J. Kucharski
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Science - Abstract
Abstract Estimating the impact of vaccination and non-pharmaceutical interventions on COVID-19 incidence is complicated by several factors, including successive emergence of SARS-CoV-2 variants of concern and changing population immunity from vaccination and infection. We develop an age-structured multi-strain COVID-19 transmission model and inference framework to estimate vaccination and non-pharmaceutical intervention impact accounting for these factors. We apply this framework to COVID-19 waves in French Polynesia and estimate that the vaccination programme averted 34.8% (95% credible interval: 34.5–35.2%) of 223,000 symptomatic cases, 49.6% (48.7–50.5%) of 5830 hospitalisations and 64.2% (63.1–65.3%) of 1540 hospital deaths that would have occurred in a scenario without vaccination up to May 2022. We estimate the booster campaign contributed 4.5%, 1.9%, and 0.4% to overall reductions in cases, hospitalisations, and deaths. Our results suggest that removing lockdowns during the first two waves would have had non-linear effects on incidence by altering accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.
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- 2023
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4. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort
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Attali, Valérie, Maria-Anna, Balice, Laurent, Barthel, Rosa, Buendia, Bertien, Buyse, Laurent, Boyer, Marie-Pierre, Cadars, Pascal, Cornec, Thibaud, Damy, Jean-Marc, Davy, Geoffroy, De Faverges, Toufik, Didi, Marie-Pia, d'ortho, Frédéric, Gagnadoux, Thibaud, Gentina, François, Goupil, Frédéric, Goutorbe, Jean-Maurice, Guillemot, Carmen, Iamandi, Richard, Isnard, François, Jounieaux, Christian, Koltes, Alain, Le Coz, Benoit, Lequeux, René, Lerest, Lionel, Lerousseau, Jean-Pierre, Mallet, Francis, Martin, Jean-Claude, Meurice, Ala, Noroc, Frédéric, Ortuno, Alain, Palot, Philippe, Papola, Audrey, Paris, Hélène, Pastinelli, Jean-Louis, Pepin, Christophe, Perrin, Carole, Philippe, Sandrine, Pontier, Arnaud, Prigent, Pascaline, Priou, Vincent, Puel, Claudio, Rabec, Benjamin, Richard, Claude, Richard, Marijke, Rutten, Manuel, Sastry, Murielle, Salvat, Kamila, Sedkaoui, Bharati, Shivalkar, Renaud, Tamisier, Dries, Testelmans, Johan, Verbraecken, Tamisier, Renaud, Damy, Thibaud, Bailly, Sébastien, Goutorbe, Frédéric, Davy, Jean-Marc, Lavergne, Florent, Palot, Alain, Verbraecken, Johan A., d’Ortho, Marie-Pia, and Pépin, Jean-Louis
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- 2024
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5. Dapagliflozin initiation in chronic heart failure patients improves central sleep apnoea
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Dany Jaffuel, Yannick Bouchaut, Jean-Pierre Mallet, Célia Vidal, Nicolas Molinari, Arnaud Bourdin, and François Roubille
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Medicine - Published
- 2023
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6. Did COVID-19 impact Positive Airway Pressure adherence in 2020? A cross-sectional study of 8477 patients with sleep apnea
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Fanny Bertelli, Carey M. Suehs, Jean-Pierre Mallet, Isabelle Court-Fortune, Frédéric Gagnadoux, Jean Christian Borel, Olivier Gaubert, Nicolas Molinari, Arnaud Bourdin, and Dany Jaffuel
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Sleep Apnea ,CPAP ,COVID 19 ,And adherence ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Whether the COVID-19 pandemic impacts Positive Airway Pressure (PAP) adherence over the long-term is unknown and only preliminary short-term data have been reported. Methods With the aim of describing the impact of the first and second waves of COVID-19 on PAP adherence during 2020 in France, we designed a cross-sectional study of Sleep-Apnea (SA)-patients under PAP telemonitoring. To examine PAP adherence in adult SA patients, we assessed de-identified data from a non-profit healthcare provider database during the period January 1, 2019 to December 31, 2020. Included patients met the following criteria: (i) PAP-treated for at least 4 months before January 1, 2019 and with continuous PAP during both 2019 and 2020; (ii) ≥ 360 daily PAP telemonitored data per year. For PAP adherence, data were collected using the PAP-software. Results 8477/10482 patients were finally included in the analysis [72.4% male, median age 70 years (IQ25–75: 61–77], 25.6%
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- 2022
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7. Sacubitril‐valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO‐SAS study
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Dany Jaffuel, Erika Nogue, Philippe Berdague, Michel Galinier, Pauline Fournier, Marion Dupuis, Frédéric Georger, Marie‐Pierre Cadars, Jean‐Etienne Ricci, Nathalie Plouvier, François Picard, Vincent Puel, Jean‐Pierre Mallet, Carey M. Suehs, Nicolas Molinari, Arnaud Bourdin, and François Roubille
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Continuous positive airway pressure ,Heart failure ,Sacubitril–valsartan ,Sleep apnoea ,Sleep‐disordered breathing ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Optimizing medical cardiac treatment for sleep apnoea (SA) in patients with chronic heart failure and reduced ejection fraction (HFrEF) is an expert Grade C recommendation based on six studies encompassing a total of 67 patients only. Whether sacubitril–valsartan (SV), a cornerstone of HFrEF medical treatment, impacts SA is unknown and requires evaluation. Methods and results The ENTRESTO‐SAS trial is a six‐centre, prospective, open‐label real‐life cohort study (NCT02916160). Ambulatory patients eligible for SV (i.e. HFrEF adults who remain symptomatic despite optimal treatment) were evaluated before and after 3 months of SV (including nocturnal ventilatory polygraphy); 118 patients were final analysed [median age was 66 (IQ25–75: 56–73) years, 81.4% male, 36.5% New York Heart Association III–IV, N‐terminal pro‐B‐type natriuretic peptide level of 1564 (701–3376) ng/L, left ventricular ejection fraction of 30 (25–34)%, 60.7% ischaemic HFrEF, 97.5% initially treated with angiotensin‐converting enzyme inhibitors or angiotensin II receptor blockers, 83.9% with beta‐blockers, 64.4% with mineralocorticoid receptor antagonists, and 74.6% with diuretics]. Three groups were defined according to initial central/obstructive apnoea–hypopnoea indices (AHIs): G1 (n = 49, AHIcentral ≥ 5/h and AHIobstructive
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- 2021
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8. Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study
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Marie-Caroline Rotty, Carey M. Suehs, Jean-Pierre Mallet, Christian Martinez, Jean-Christian Borel, Claudio Rabec, Fanny Bertelli, Arnaud Bourdin, Nicolas Molinari, and Dany Jaffuel
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Sleep apnea ,Leaks ,Side-effects ,Telemedicine ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the relationship between mask related side-effects (MRSEs) and CPAP-non-adherence (defined as
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- 2021
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9. Apnoea–hypopnoea indices determined via continuous positive airway pressure (AHI-CPAPflow) versus those determined by polysomnography (AHI-PSGgold): a protocol for a systematic review and meta-analysis
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Jean Louis Pepin, Nicolas Molinari, Frédéric Gagnadoux, A Bourdin, Carey Meredith Suehs, Fanny Bertelli, Jean Pierre Mallet, Marie Caroline Rotty, Eric Matzner-Lober, and Dany Jaffuel
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Medicine - Abstract
Introduction To date, continuous positive airway pressure (CPAP) remains the cornerstone of obstructive sleep apnoea treatment. CPAP data describing residual sleep-disordered breathing events (ie, the CPAP-measured apnoea–hypopnoea indices (AHI-CPAPflow)) is difficult to interpret because it is an entirely different metric than the polysomnography (PSG) measured AHI gold standard (AHI-PSGgold). Moreover, manufacturer definitions for apnoea and hypopnoea are not only different from those recommended for PSG scoring, but also different between manufacturers. In the context of CPAP initiation and widespread telemedicine at home to facilitate sleep apnoea care, there is a need for concrete evidence that AHI-CPAPflow can be used as a surrogate for AHI-PSGgold.Methods and analysis No published systematic review and meta-analysis (SRMA) has compared the accuracy of AHI-CPAPflow against AHI-PSGgold and the primary objective of this study is therefore to do so using published data. The secondary objectives are to similarly evaluate other sleep disordered breathing indices and to perform subgroup analyses focusing on the inclusion/exclusion of central apnoea patients, body mass index levels, CPAP device brands, pressure titration modes, use of a predetermined and fixed pressure level or not, and the impact of a 4% PSG desaturation criteria versus 3% PSG on accuracy. The Preferred Reporting Items for SRMA protocols statement guided study design. Randomised controlled trials and observational studies of adult patients (≥18 years old) treated by a CPAP device will be included. The CPAP intervention and PSG comparator must be performed synchronously. PSGs must be scored manually and follow the American Academy of Sleep Medicine guidelines (2007 AASM criteria or more recent). To assess the risk of bias in each study, the Quality Assessment of Diagnostic Accuracy Studies 2 tool will be used.Ethics and dissemination This protocol received ethics committee approval on 16 July 2020 (IRB_MTP_2020_07_2020000404) and results will be disseminated via peer-reviewed publications.PROSPERO/Trial registration numbers CRD42020159914/NCT04526366; Pre-results
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- 2021
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10. Les enjeux de la numérisation pour les gestionnaires du réseau de distribution
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Sébastien Jumel and Pierre Mallet
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General Medicine - Published
- 2023
11. Club Cell Loss as a Feature of Bronchiolization in ILD
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Paul Reynaud, Engi Ahmed, Isabelle Serre, Lucie Knabe, Sébastien Bommart, Carey Suehs, Isabelle Vachier, Jean Philippe Berthet, Micaela Romagnoli, Charlotte Vernisse, Jean Pierre Mallet, Anne Sophie Gamez, and Arnaud Bourdin
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club (clara) cell ,idiopathic pulmonary fibrosis ,metaplasia ,SCGB1A1 ,bronchiolization ,interstitial lung disease ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: Distal airway metaplasia may precede honeycombing in progressive fibrosing interstitial lung disease (ILD). The SCGB1A1+ bronchiolar-specific club cell may play a role in this aberrant regenerative process.Objective: To assess the presence of club cells in the small airways of patients suffering from ILD.Methods: Small airways (internal diameter
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- 2021
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12. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016
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Lorenzo Subissi, Timothée Dub, Marianne Besnard, Teheipuaura Mariteragi-Helle, Tuxuan Nhan, Delphine Lutringer-Magnin, Philippe Barboza, Céline Gurry, Pauline Brindel, Eric J. Nilles, David Baud, Angela Merianos, Didier Musso, Judith R. Glynn, Gilles Dupuis, Van-Mai Cao-Lormeau, Marine Giard, and Henri-Pierre Mallet
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Zika virus infection ,Pacific Islands ,French Polynesia ,congenital Zika syndrome ,child health ,viruses ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed.
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- 2018
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13. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort
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Tamisier, Renaud, primary, Damy, Thibaud, additional, Bailly, Sébastien, additional, Goutorbe, Frédéric, additional, Davy, Jean-Marc, additional, Lavergne, Florent, additional, Palot, Alain, additional, Verbraecken, Johan A., additional, d’Ortho, Marie-Pia, additional, Pépin, Jean-Louis, additional, Tamisier, Renaud, additional, Attali, Valérie, additional, Maria-Anna, Balice, additional, Laurent, Barthel, additional, Rosa, Buendia, additional, Bertien, Buyse, additional, Laurent, Boyer, additional, Marie-Pierre, Cadars, additional, Pascal, Cornec, additional, Thibaud, Damy, additional, Jean-Marc, Davy, additional, Geoffroy, De Faverges, additional, Toufik, Didi, additional, Marie-Pia, d'ortho, additional, Frédéric, Gagnadoux, additional, Thibaud, Gentina, additional, François, Goupil, additional, Frédéric, Goutorbe, additional, Jean-Maurice, Guillemot, additional, Carmen, Iamandi, additional, Richard, Isnard, additional, François, Jounieaux, additional, Christian, Koltes, additional, Alain, Le Coz, additional, Benoit, Lequeux, additional, René, Lerest, additional, Lionel, Lerousseau, additional, Jean-Pierre, Mallet, additional, Francis, Martin, additional, Jean-Claude, Meurice, additional, Ala, Noroc, additional, Frédéric, Ortuno, additional, Alain, Palot, additional, Philippe, Papola, additional, Audrey, Paris, additional, Hélène, Pastinelli, additional, Jean-Louis, Pepin, additional, Christophe, Perrin, additional, Carole, Philippe, additional, Sandrine, Pontier, additional, Arnaud, Prigent, additional, Pascaline, Priou, additional, Vincent, Puel, additional, Claudio, Rabec, additional, Benjamin, Richard, additional, Claude, Richard, additional, Marijke, Rutten, additional, Manuel, Sastry, additional, Murielle, Salvat, additional, Kamila, Sedkaoui, additional, Bharati, Shivalkar, additional, Renaud, Tamisier, additional, Dries, Testelmans, additional, and Johan, Verbraecken, additional
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- 2023
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14. The legal value of Zoom’s contractual terms: A comparative analysis of the UAE and French law
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Pierre Mallet, Najlaa Flayyih, and Zeana Ghanim Abdijabar
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Law ,Computer Science Applications - Published
- 2022
15. Towards a cognitive warning system for safer hybrid traffic.
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ágoston Török, Krisztián Varga, Jean-Marie Pergandi, Pierre Mallet, Ferenc Honbolygo, Valéria Csépe, and Daniel Mestre
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- 2017
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16. Zika Virus Seroprevalence, French Polynesia, 2014–2015
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Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Didier Musso, Xavier Deparis, and Van-Mai Cao-Lormeau
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Zika virus ,Zika ,French Polynesia ,flavivirus ,arbovirus ,seroprevalence ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
During 2013–2014, French Polynesia experienced an outbreak of Zika virus infection. Serosurveys conducted at the end of the outbreak and 18 months later showed lower than expected disease prevalence rates (49%) and asymptomatic:symptomatic case ratios (1:1) in the general population but significantly different prevalence rates (66%) and asymptomatic:symptomatic ratios (1:2) in schoolchildren.
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- 2017
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17. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia
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Lloyd Chapman, Maite Aubry, Noemie Maset, Timothy Russell, Edward Knock, John Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam Kucharski
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Estimation of the impact of vaccination and non-pharmaceutical interventions (NPIs) on COVID-19 incidence is complicated by several factors, including the successive emergence of SARS-CoV-2 variants of concern and changing population immunity resulting from vaccination and previous infection. We developed an age-structured multi-strain COVID-19 transmission model framework that could estimate the impact of vaccination and NPIs while accounting for these factors. We applied this framework to French Polynesia, which unlike many countries experienced multiple large COVID-19 waves from multiple variants over the course of the pandemic, interspersed with periods of elimination. We estimated that the vaccination programme averted 54.3% (95% CI 54.0-54.6%) of the 6840 hospitalisations and 60.2% (95% CI 59.9-60.5%) of the 1280 hospital deaths that would have occurred in a baseline scenario without any vaccination up to May 2022. Vaccination also averted an estimated 28.4% (95% CI 28.2-28.7%) of 193,000 symptomatic cases in the baseline scenario. We estimated the booster campaign contributed 3.4%, 2.9% and 3.3% to overall reductions in cases, hospitalisations and hospital deaths respectively. Our results suggested that removing, or altering the timings of, the lockdowns during the first two waves had non-linear effects on overall incidence owing to the resulting effect on accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.
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- 2023
18. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia
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Lloyd AC Chapman, Maite Aubry, Noémie Maset, Timothy W Russell, Edward S Knock, John A Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam J Kucharski
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Estimation of the impact of vaccination and non-pharmaceutical interventions (NPIs) on COVID-19 incidence is complicated by several factors, including the successive emergence of SARS-CoV-2 variants of concern and changing population immunity resulting from vaccination and previous infection. We developed an age-structured multi-strain COVID-19 transmission model framework that could estimate the impact of vaccination and NPIs while accounting for these factors. We applied this approach to French Polynesia, which unlike many countries experienced multiple large COVID-19 waves from multiple variants over the course of the pandemic, interspersed with periods of elimination. We estimated that the vaccination programme averted 54.3% (95% CI 54.0-54.6%) of the 6840 hospitalisations and 60.2% (95% CI 59.9–60.5%) of the 1280 hospital deaths that would have occurred in a baseline scenario without any vaccination up to May 2022. Vaccination also averted an estimated 28.4% (95% CI 28.2-28.7%) of 193,000 symptomatic cases in the baseline scenario. We estimated the booster campaign contributed 3.4%, 2.9% and 3.3% to overall reductions in cases, hospitalisations and hospital deaths respectively. Our results suggested that removing, or altering the timings of, the lockdowns during the first two waves had non-linear effects on overall incidence owing to the resulting effect on accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.
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- 2023
19. Le lien hypertexte et le droit de l’auteur de communiquer ses œuvres au public (A propos des arrêts de la CJUE dans les affaires Svensson et Gs Media)
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Laroussi Chemlali and Pierre Mallet
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Placer un lien pointant vers un site tiers qui publie des œuvres protégées, sans l’autorisation du titulaire du droit d’auteur, constitue-t-il une communication de ces œuvres au public selon l’article 3, paragraphe 1, de la directive 2001/29 ? Telle était la question à laquelle la Cour de justice de l'Union européenne avait à répondre dans sa jurisprudence récente sur les liens hypertexte. Le présent article est destiné à donner un bref aperçu et une analyse critique des réponses avancées par la Cour, particulièrement dans les arrêts Svensson et Gs Media. Dans cette optique, deux cas de figures sont évoqués : dans un premier temps, nous envisageons le cas des liens hypertexte pointant vers des œuvres licitement mises en ligne. Puis, dans un second temps, il est question des liens renvoyant vers un contenu protégé mis illicitement en ligne.
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- 2022
20. The search for manganese incorporation in MoSe 2 monolayer epitaxially grown on graphene
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Maxime Gay, Minh-Tuan Dau, Céline Vergnaud, Alain Marty, Frédéric Bonell, Hervé Boukari, Colin Paillet, Bérangère Hyot, Hanako Okuno, Pierre Mallet, Jean-Yves Veuillen, Olivier Renault, Matthieu Jamet, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Modélisation et Exploration des Matériaux (MEM), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Nano-Electronique Quantique et Spectroscopie (QuNES), ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018), ANR-10-LABX-0051,LANEF,Laboratory of Alliances on Nanosciences - Energy for the Future(2010), Nanophysique et Semiconducteurs (NEEL - NPSC), and Nano-Electronique Quantique et Spectroscopie (NEEL - QuNES)
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Materials science ,Graphene ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,Manganese ,2D materials ,021001 nanoscience & nanotechnology ,Epitaxy ,01 natural sciences ,law.invention ,Crystallography ,chemistry ,law ,0103 physical sciences ,Monolayer ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Magnetic doping ,[PHYS.COND]Physics [physics]/Condensed Matter [cond-mat] ,Scanning tunneling microscopy ,010306 general physics ,0210 nano-technology ,Molecular beam epitaxy ,Transmission electron microscopy ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2022
21. Ferromagnetism and Rashba Spin–Orbit Coupling in the Two-Dimensional (V,Pt)Se2 Alloy
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Emilio Vélez-Fort, Ali Hallal, Roberto Sant, Thomas Guillet, Khasan Abdukayumov, Alain Marty, Céline Vergnaud, Jean-François Jacquot, Denis Jalabert, Jun Fujii, Ivana Vobornik, Julien Rault, Nicholas B. Brookes, Danilo Longo, Philippe Ohresser, Abdelkarim Ouerghi, Jean-Yves Veuillen, Pierre Mallet, Hervé Boukari, Hanako Okuno, Mairbek Chshiev, Frédéric Bonell, Matthieu Jamet, SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), European Synchrotron Radiation Facility (ESRF), Conception d’Architectures Moléculaires et Processus Electroniques (CAMPE ), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Modélisation et Exploration des Matériaux (MEM), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Laboratorio TASC (IOM CNR), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), CNR Istituto Officina dei Materiali (IOM), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Nano-Electronique Quantique et Spectroscopie (NEEL - QuNES), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Nanophysique et Semiconducteurs (NEEL - NPSC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018), ANR-10-LABX-0051,LANEF,Laboratory of Alliances on Nanosciences - Energy for the Future(2010), and European Project: 785219,H2020,GrapheneCore2(2018)
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Condensed Matter::Materials Science ,Materials Chemistry ,Electrochemistry ,Condensed Matter::Strongly Correlated Electrons ,[PHYS.COND]Physics [physics]/Condensed Matter [cond-mat] ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Electronic, Optical and Magnetic Materials - Abstract
5 pages, 5 figures; International audience; We report on a two-dimensional (2D) V1–xPtxSe2 alloy that exhibits ferromagnetic order and Rashba spin–orbit coupling. Although ferromagnetism is absent in 1T-VSe2 because of the competition with the charge density wave phase, we demonstrate theoretically and experimentally that the substitution of vanadium by platinum in VSe2 (10–50%) to form a homogeneous 2D alloy restores ferromagnetic order down to one monolayer of V0.65Pt0.35Se2. Moreover, the presence of platinum atoms gives rise to Rashba spin–orbit coupling in (V,Pt)Se2, providing an original platform to study the interplay between ferromagnetism and spin–orbit coupling in the 2D limit.
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- 2022
22. The Civil Fine in French Law as an Alternative to Punitive Damages
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pierre mallet
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- 2023
23. Accuracy of continuous positive airway pressure devices: the devil is in the details, the best is yet to come
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Dany Jaffuel, Jean-Pierre Mallet, and AbdelKebir Sabil
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Otorhinolaryngology ,Neurology (clinical) - Published
- 2022
24. It sounds real when you see it. Realistic sound source simulation in multimodal virtual environments.
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ágoston Török, Daniel Mestre, Ferenc Honbolygo, Pierre Mallet, Jean-Marie Pergandi, and Valéria Csépe
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- 2015
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25. Investigation of a Virtual Environment for Rugby Skills Training.
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Helen C. Miles, Serban R. Pop, Simon J. Watt, Gavin P. Lawrence, Nigel W. John, Vincent Perrot, Pierre Mallet, and Daniel Mestre
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- 2013
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26. Évolution à 6 mois de la qualité du sommeil dans le syndrome d’apnées centrales du sommeil (SACS) traitées par VAA : étude FACIL-VAA
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Renaud Tamisier, Carole Philippe, Arnaud Prigent, Christelle Charley-Monaca, Marie-Pia D’Ortho, Thibaut Gentina, Frédéric Gagnadoux, Claire Launois, Jean-Pierre Mallet, Toufik Didi, Tiphaine Guy, Frédéric Goutorbe, Christophe Perrin, Sandrine Pontier-Marchandise, Jean-François Timsit, Jean-Louis Pepin, and Jean Claude Meurice
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Behavioral Neuroscience ,Neuropsychology and Physiological Psychology ,Neurology ,Cognitive Neuroscience ,Neurology (clinical) - Published
- 2023
27. Salmonella enterica Serotype Enteritidis in French Polynesia, South Pacific, 2008–2013
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Simon Le Hello, Fiona Maillard, Henri-Pierre Mallet, Elise Daudens, Marc Levy, Valérie Roy, Philippe Branaa, Sophie Bertrand, Laetitia Fabre, and François-Xavier Weill
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S. enterica serotype Enteritidis ,CRISPR ,MLVA ,laying hen ,French Polynesia ,South Pacific ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Outbreaks of Salmonella enterica serotype Enteritidis infections associated with eggs occurred in French Polynesia during 2008–2013. Molecular analysis of isolates by using clustered regularly interspaced short palindromic repeat polymorphisms and multilocus variable-number tandem-repeat analysis was performed. This subtyping made defining the epidemic strain, finding the source, and decontaminating affected poultry flocks possible.
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- 2015
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28. Les mouvements mandibulaires peuvent-ils être utilisés comme moyen de dépistage des patients candidats à une polysomnographie ?
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Marie-Caroline Rotty, Nicolas Molinari, Carey M. Suehs, Dany Jaffuel, Jean Pierre Mallet, Arnaud Bourdin, and Jean-Christian Borel
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Behavioral Neuroscience ,apnée du sommeil ,Neuropsychology and Physiological Psychology ,Neurology ,polysomnography ,Cognitive Neuroscience ,screening ,Brizzy ,Neurology (clinical) ,SAHOS ,sleep apnea ,poster ,mandibular movements - Abstract
Objectif Les mouvements mandibulaires (MM) sont desormais consideres comme une mesure diagnostique de l’effort respiratoire et pourraient etre utilises comme methode de depistage des patients eligibles a une polysomnographie (PSG). Nous rapportons ici la faisabilite d’un depistage fonde sur la mesure d’un index respiratoire associe a des mouvements mandibulaires (MM-RDI). Methodes Au total, 4231 patients ont effectue en ambulatoire un test de depistage Brizzy (depist-By) a l’aide un capteur magnetique (Nomics©) ; 918 patients ont simultanement beneficie d’une oxymetrie. Le patient etait considere comme positif et necessitant une PSG si le MM-RDI etait > 13,5/h ou si l’indice de desaturation de l’oxygene (IDO) etait > 18,5/h (sous condition d’une estimation du temps de sommeil total [eTST] > 4 heures). Resultats Parmi les tests, 3,9 % etaient non exploitables en raison d’une defaillance technique. Seulement 3,2 % de la population analysable avait une eTST Conclusion Cette etude preliminaire confirme la faisabilite du MM-RDI comme outil de depistage pour les patients candidats a la PSG. Elle suggere une complementarite de l’oxymetrie et du depist-By.
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- 2022
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29. Efficacy of a Virtual Environment for Training Ball Passing Skills in Rugby.
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Helen C. Miles, Serban R. Pop, Simon J. Watt, Gavin P. Lawrence, Nigel W. John, Vincent Perrot, Pierre Mallet, Daniel Mestre, and Kenton Morgan
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- 2014
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30. Field margins as substitute habitat for the conservation of birds in agricultural wetlands
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Pierre, Mallet, primary, Arnaud, Béchet, additional, Clélia, Sirami, additional, François, Mesléard, additional, Thomas, Blanchon, additional, François, Calatayud, additional, Thomas, Dagonet, additional, Elie, Gaget, additional, Carole, Leray, additional, and Thomas, Galewski, additional
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- 2022
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31. Muscle sympathetic nerve activity and adaptive servo-ventilation: questions remain
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Dany Jaffuel, Jean Pierre Mallet, François Roubille, and Arnaud Bourdin
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Pulmonary and Respiratory Medicine - Published
- 2023
32. Texture Feature Characterization for Logical Pre-labeling.
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Bénédicte Allier, Jean Duong, Antoine Gagneux, Pierre Mallet, and Hubert Emptoz
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- 2003
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33. WAD project where attractor dynamics aids wheelchair navigation.
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Pierre Mallet and Gregor Schöner
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- 2002
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34. Feasibility of Type 3 Polygraphy for Evaluating Leak Determinants in CPAP-Treated OSA Patients
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Jean-Pierre Mallet, Marie-Caroline Rotty, Loïc Lambert, Jean-Louis Pépin, Carey M. Suehs, Jean-Christian Borel, Eric Matzner-Løber, Marius Lebret, Dany Jaffuel, and Nicolas Molinari
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Pulmonary and Respiratory Medicine ,Leak ,medicine.medical_specialty ,education.field_of_study ,Supine position ,medicine.diagnostic_test ,business.industry ,Concordance ,Population ,Polysomnography ,Recording system ,Critical Care and Intensive Care Medicine ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Emergency medicine ,medicine ,In patient ,Positional Treatment ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,education ,business - Abstract
Background Unintentional leaks (ULs) are frequent adverse effects in CPAP-treated patients. We previously published a novel methodology for analyzing the determinants of UL using polysomnography. We now propose a simplified recording system using a type 3 polygraphic device (Somnolter; Nomics S.A.). Research Question (1) To describe individual UL determinants provided by the Somnolter software in automatic-CPAP-treated OSA patients; (2) To subsequently describe the clinical consensus of four physicians on how to manage each individual UL situation. Study Design and Methods Somnoler recordings performed under nasal automatic-CPAP were automatically analyzed with APIOS software. For each polygraphic recording, APIOS provided the OR and the CIs for potential determinants of UL: mouth opening, CPAP pressure, body position, and mandibular oscillation. Based on these results, each of four physicians was asked to choose one of four strategies: (1) increase or decrease therapeutic pressure; (2) change nasal mask for oro-nasal mask/chinstrap; (3) favor a nonsupine or supine position; (4) no action for individual leak management. Subsequently, a meeting was held to determine a consensus choice for each individual case. Results Seventy-eight consecutive patients underwent home-polygraphy with Somnolter. Fifty recordings were analyzed (16 females; 65 [57-75] years of age; BMI = 31.1 [27.4-35.3]). Individual diagnosis of UL was routinely feasible. The determinants of UL were heterogeneous in the population, and diagnosis of UL was not feasible in 10 patients. Based on the results from this analysis, we established consensus leak management strategies at the individual level. The average Cohen κ coefficient for the four raters was 0.58. Pressure modification was proposed in 36% of patients, no action in 24%, installation of a facial mask/chinstrap in 22%, and positional treatment in 18%. Interpretation The use of type 3 polygraphy for characterizing leak determinants in patients treated with nasal automatic-CPAP is feasible in routine practice. Leak determinants are patient specific. Interrater concordance for determining individual leak management strategies demonstrated a “fair” level of agreement. Trial Registry ClinicalTrials.gov ; No.: NCT03381508; URL: www.clinicaltrials.gov ).
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- 2020
35. Impact on blood safety of the last arboviruses outbreaks in French Polynesia (2012–2018)
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Julien Broult, Sylvie Mauguin, Stéphane Lastère, Syria Laperche, Frédéric Beau, and Henri-Pierre Mallet
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Serotype ,Blood Safety ,Clinical Biochemistry ,Blood Donors ,030204 cardiovascular system & hematology ,Nucleic Acid Testing ,medicine.disease_cause ,Arbovirus ,Polynesia ,Disease Outbreaks ,Donor Selection ,Dengue fever ,Dengue ,03 medical and health sciences ,0302 clinical medicine ,Seroepidemiologic Studies ,Furocoumarins ,Blood-Borne Pathogens ,medicine ,Humans ,Viremia ,Chikungunya ,Photosensitizing Agents ,Zika Virus Infection ,Transmission (medicine) ,business.industry ,Biochemistry (medical) ,virus diseases ,Outbreak ,Hematology ,medicine.disease ,Virology ,Chikungunya Fever ,RNA, Viral ,Blood safety ,business ,Arboviruses ,030215 immunology - Abstract
Background Several successive arbovirus outbreaks have affected French Polynesia (FP) in the recent past years due to different dengue serotypes (DENV) present for several decades, Zika (ZIKV) (2013–2014) and chikungunya (CHIKV) (2014–2015) viruses with a potential impact on blood safety and blood supply due to the geographical isolation of these islands. This study reports an assessment of the impact of these outbreaks on blood products supply and infectious safety in FP and discuss the effectiveness of implemented preventive measures. Methods To ensure the infectious safety of blood products during outbreaks, several measures have successively been introduced as the selection of donors suspected of infection, the nucleic acid testing (NAT) and the pathogen reduction of platelets and plasmas. Results The donor deferral rate increased by 6% between 2012 and 2014 without changes in the number of collected donations. NAT excluded five blood donations reactive for DENV RNA, 42 for ZIKV and 34 for CHIKV. As Zika screening could not been implemented before the third month of the outbreak, 36 blood products from ZIKV-infected donors were transfused to 26 recipients. However, no transfusion-transmitted arbovirus has been reported. Conclusion The last past arboviruses outbreaks did not have a significant impact on blood supply in FP. The measures introduced to prevent arbovirus transmission by transfusion were able to maintain infectious safety for all blood products without impairing self-sufficiency.
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- 2020
36. Amikacin Liposomal Inhalation Suspension in the Treatment of Mycobacterium abscessus Lung Infection: A French Observational Experience
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Raphael Chiron, Wouter Hoefsloot, Jakko Van Ingen, Hélène Marchandin, Laurent Kremer, Hélène Morisse-Pradier, Jeremy Charriot, Jean-Pierre Mallet, Jean-Louis Herrmann, Davide Caimmi, Johan Moreau, Yann Dumont, Sylvain Godreuil, Anne Bergeron, Margot Drevait, Elodie Bouzat-Rossigneux, Nicolas Terrail, Claire Andrejak, Nicolas Veziris, Dominique Grenet, Alexandre Coudrat, Emilie Catherinot, Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Radboud University Medical Center [Nijmegen], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Hopital Saint-Louis [AP-HP] (AP-HP), Equipe 2 : ECSTRA - Epidémiologie Clinique, STatistique, pour la Recherche en Santé (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Foch [Suresnes], Centre National de Référence des Mycobactéries et de la Résistance aux Antituberculeux [CHU Pitié-Salpêtrière] (CNR-MyRMA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and MORNET, Dominique
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Mycobacterium abscessus ,Amikacin liposomal inhalation suspension ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Cystic fibrosis ,Treatment ,All institutes and research themes of the Radboud University Medical Center ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Infectious Diseases ,Oncology ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Nontuberculous mycobacteria - Abstract
Background Mycobacterium abscessus infections remain difficult to manage in both cystic fibrosis (CF) and non-CF patients and reported clinical outcomes are largely unsatisfactory. Clinical trial data are limited and no approved therapies are currently available for the management of M abscessus lung diseases. As an alternative, cohort studies may provide insightful information into the management of M abscessus pulmonary disease. Methods Based on a retrospective observational cohort study, we investigated the safety and efficacy of amikacin liposome inhaled suspension (ALIS) as an adjunct to a standard antibiotic regimen for M abscessus lung infection in both CF and non-CF patients. We also assessed the association of patient drug compliance with culture conversion and clinical outcomes. Results Twenty-six patients had long-term follow-up data available. Culture conversion was achieved in 54% (14/26) of the patients with no difference between CF and non-CF patients after an average treatment duration of 10 months. Patient treatment compliance was significantly better in the converter group compared to nonconverters with an odds ratio of 44.78 associated with good compared to poor patient compliance. Overall, 9 patients (35%) experienced an adverse event that led to treatment discontinuation. Conclusions ALIS appears beneficial in both CF and non-CF populations with M abscessus lung disease.
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- 2022
37. Zika Virus, French Polynesia, South Pacific, 2013
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Van-Mai Cao-Lormeau, Claudine Roche, Anita Teissier, Emilie Robin, Anne-Laure Berry, Henri-Pierre Mallet, Amadou Alpha Sall, and Didier Musso
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Zika virus ,outbreak ,French Polynesia ,South Pacific ,viruses ,flavivirus ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Published
- 2014
- Full Text
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38. Apnoea-hypopnoea indices determined via continuous positive airway pressure (AHI-CPAP
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Fanny, Bertelli, Carey Meredith, Suehs, Jean Pierre, Mallet, Marie Caroline, Rotty, Jean Louis, Pepin, Frédéric, Gagnadoux, Eric, Matzner-Lober, A, Bourdin, Nicolas, Molinari, and Dany, Jaffuel
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Adult ,Sleep Apnea, Obstructive ,Adolescent ,Continuous Positive Airway Pressure ,Polysomnography ,sleep medicine ,heart failure ,Telemedicine ,nervous system diseases ,respiratory tract diseases ,Body Mass Index ,Meta-Analysis as Topic ,respiratory physiology ,Humans ,Respiratory Medicine ,Systematic Reviews as Topic - Abstract
Introduction To date, continuous positive airway pressure (CPAP) remains the cornerstone of obstructive sleep apnoea treatment. CPAP data describing residual sleep-disordered breathing events (ie, the CPAP-measured apnoea–hypopnoea indices (AHI-CPAPflow)) is difficult to interpret because it is an entirely different metric than the polysomnography (PSG) measured AHI gold standard (AHI-PSGgold). Moreover, manufacturer definitions for apnoea and hypopnoea are not only different from those recommended for PSG scoring, but also different between manufacturers. In the context of CPAP initiation and widespread telemedicine at home to facilitate sleep apnoea care, there is a need for concrete evidence that AHI-CPAPflow can be used as a surrogate for AHI-PSGgold. Methods and analysis No published systematic review and meta-analysis (SRMA) has compared the accuracy of AHI-CPAPflow against AHI-PSGgold and the primary objective of this study is therefore to do so using published data. The secondary objectives are to similarly evaluate other sleep disordered breathing indices and to perform subgroup analyses focusing on the inclusion/exclusion of central apnoea patients, body mass index levels, CPAP device brands, pressure titration modes, use of a predetermined and fixed pressure level or not, and the impact of a 4% PSG desaturation criteria versus 3% PSG on accuracy. The Preferred Reporting Items for SRMA protocols statement guided study design. Randomised controlled trials and observational studies of adult patients (≥18 years old) treated by a CPAP device will be included. The CPAP intervention and PSG comparator must be performed synchronously. PSGs must be scored manually and follow the American Academy of Sleep Medicine guidelines (2007 AASM criteria or more recent). To assess the risk of bias in each study, the Quality Assessment of Diagnostic Accuracy Studies 2 tool will be used. Ethics and dissemination This protocol received ethics committee approval on 16 July 2020 (IRB_MTP_2020_07_2020000404) and results will be disseminated via peer-reviewed publications. PROSPERO/Trial registration numbers CRD42020159914/NCT04526366; Pre-results
- Published
- 2021
39. Target Representation on an Autonomous Vehicle with Low-Level Sensors.
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Estela Bicho, Pierre Mallet, and Gregor Schöner
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- 2000
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40. Sacubitril‐valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO‐SAS study
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Jean-Etienne Ricci, Jean-Pierre Mallet, Nathalie Plouvier, François Roubille, Pauline Fournier, Vincent Puel, Nicolas Molinari, Frédéric Georger, François Picard, Arnaud Bourdin, Philippe Berdague, Erika Nogue, Marion Dupuis, Carey M. Suehs, Michel Galinier, Marie-Pierre Cadars, Dany Jaffuel, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Montpelliérain Alexander Grothendieck (IMAG), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
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Male ,medicine.medical_treatment ,Sacubitril-valsartan ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Cohort Studies ,Sleep apnoea ,0302 clinical medicine ,Original Research Articles ,Positive airway pressure ,030212 general & internal medicine ,Continuous positive airway pressure ,Prospective Studies ,Original Research Article ,education.field_of_study ,Ejection fraction ,Aminobutyrates ,Sleep apnea ,3. Good health ,Drug Combinations ,Ambulatory ,Cardiology ,Valsartan ,Female ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Population ,Heart failure ,03 medical and health sciences ,Sleep Apnea Syndromes ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Sleep‐disordered breathing ,education ,Sleep-disordered breathing ,Aged ,business.industry ,Biphenyl Compounds ,Stroke Volume ,Sacubitril–valsartan ,medicine.disease ,respiratory tract diseases ,RC666-701 ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,business ,Sacubitril, Valsartan - Abstract
International audience; Aims Optimizing medical cardiac treatment for sleep apnoea (SA) in patients with chronic heart failure and reduced ejection fraction (HFrEF) is an expert Grade C recommendation based on six studies encompassing a total of 67 patients only. Whether sacubitril-valsartan (SV), a cornerstone of HFrEF medical treatment, impacts SA is unknown and requires evaluation.Methods and results The ENTRESTO-SAS trial is a six-centre, prospective, open-label real-life cohort study (NCT02916160). Ambulatory patients eligible for SV (i.e. HFrEF adults who remain symptomatic despite optimal treatment) were evaluated before and after 3 months of SV (including nocturnal ventilatory polygraphy); 118 patients were final analysed [median age was 66 (IQ 25-75 : 56-73) years, 81.4% male, 36.5% New York Heart Association III-IV, N-terminal pro-B-type natriuretic peptide level of 1564 (701-3376) ng/L, left ventricular ejection fraction of 30 (25-34)%, 60.7% ischaemic HFrEF, 97.5% initially treated with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, 83.9% with beta-blockers, 64.4% with mineralocorticoid receptor antagonists, and 74.6% with diuretics]. Three groups were defined according to initial central/obstructive apnoea-hypopnoea indices (AHIs): G1 (n = 49, AHI central ≥ 5/h and AHI obstructive < 15/h); G2 (n = 27, AHI obstructive ≥ 15/h); and G3 (n = 42, AHI central < 5/h and AHI obstructive < 15/h). At 3 months, the AHI (main predefined outcome) decreased significantly by À7.10/h (IQ 25-75 : À16.10 to 0.40; P < 0.001) in G1 + G2 without positive airway pressure treatment (45 patients, median initial AHI of 24.20 (IQ 25-75 : 16.40-43.50)/h). Of these, 24.4% presented an AHI decrease ≥50% and 37.78% had a final AHI < 15/h (tendency for improvement from an initial value of 20%: P = 0.0574). For G1 patients (n = 37), AHI significantly decreased from a median of 22.90 (16.00-43.50)/h to 19.20 (12.70-31.10)/h (P = 0.002). For G2 patients (n = 8), AHI decreased from a median of 30.10 (26.40-47.60)/h to 22.75 (14.60-36.90)/h (statistically non-significant, P = 0.059).Conclusions In this real-life population, SV treatment for 3 months in SA patients is associated with a significant decrease in AHI. These results support the current guidelines that recommend first an optimization of the HFrEF treatment in patients with HFrEF and central SA. A potential positive airway pressure sparing effect merits further investigation.
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- 2021
41. Observation of Yu–Shiba–Rusinov States in Superconducting Graphene
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Jean-Yves Veuillen, Eva Cortés-del Río, Joaquín Fernández-Rossier, V. Cherkez, Juan Carlos Cuevas, Ivan Brihuega, Pierre Mallet, Jose L. Lado, José M. Gómez-Rodríguez, Universidad de Alicante. Departamento de Física Aplicada, Grupo de Nanofísica, Departamento de Fisica de la Materia Condensada [Madrid] (FMC), Facultad de Ciencas [Madrid], Universidad Autonoma de Madrid (UAM)-Universidad Autonoma de Madrid (UAM), Aalto University, Nano-Electronique Quantique et Spectroscopie (QuNES), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Universidad Autonoma de Madrid (UAM), Universidad de Alicante, and Departamento de Física Aplicada [UAM Madrid]
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Superconductivity ,Materials science ,Física de la Materia Condensada ,Mechanical Engineering ,Yu–Shiba–Rusinov states ,European Regional Development Fund ,Magnetism ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Topology ,0104 chemical sciences ,[PHYS.COND.CM-S]Physics [physics]/Condensed Matter [cond-mat]/Superconductivity [cond-mat.supr-con] ,Work (electrical) ,Mechanics of Materials ,Condensed Matter::Superconductivity ,Grain boundaries ,Regional science ,General Materials Science ,Graphene ,0210 nano-technology - Abstract
When magnetic atoms are inserted inside a superconductor, the superconducting order is locally depleted as a result of the antagonistic nature of magnetism and superconductivity. Thereby, distinctive spectral features, known as Yu–Shiba–Rusinov states, appear inside the superconducting gap. The search for Yu–Shiba–Rusinov states in different materials is intense, as they can be used as building blocks to promote Majorana modes suitable for topological quantum computing. Here, the first observation of Yu–Shiba–Rusinov states in graphene, a non-superconducting 2D material, and without the participation of magnetic atoms, is reported. Superconductivity in graphene is induced by proximity effect brought by adsorbing nanometer-scale superconducting Pb islands. Using scanning tunneling microscopy and spectroscopy the superconducting proximity gap is measured in graphene, and Yu–Shiba–Rusinov states are visualized in graphene grain boundaries. The results reveal the very special nature of those Yu–Shiba–Rusinov states, which extends more than 20 nm away from the grain boundaries. These observations provide the long-sought experimental confirmation that graphene grain boundaries host local magnetic moments and constitute the first observation of Yu–Shiba–Rusinov states in a chemically pure system. This work was supported by AEI and FEDER under projects MAT2016-80907-P and MAT2016-77852-C2-2-R (AEI/FEDER, UE), by the Fundación Ramón Areces, and by the Comunidad de Madrid NMAT2D-CM program under grant S2018/NMT-4511. J.F.R. acknowledges financial support European Regional Development Fund Project No. NORTE-01-50145- FEDER-000019, and the UTAPEXPL/NTec/0046/2017 projects, as well as Generalitat Valenciana funding Prometeo2017/139 and MINECO Spain (Grant No. MAT2016-78625-C2). J.L.L is grateful for financial support from the Academy of Finland Projects Nos. 331342 and 336243.
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- 2021
42. Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study
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Nicolas Molinari, Jean-Pierre Mallet, Carey M. Suehs, Claudio Rabec, Christian Martinez, Arnaud Bourdin, Marie-Caroline Rotty, Jean-Christian Borel, Fanny Bertelli, Dany Jaffuel, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
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Male ,medicine.medical_specialty ,Sleepiness ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Demographic data ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Side-effects ,Continuous positive airway pressure ,Prospective Studies ,Trial registration ,Nose ,ComputingMilieux_MISCELLANEOUS ,Aged ,lcsh:RC705-779 ,Sleep Apnea, Obstructive ,Continuous Positive Airway Pressure ,business.industry ,Research ,Sleep apnea ,lcsh:Diseases of the respiratory system ,Middle Aged ,Leaks ,medicine.disease ,Telemedicine ,3. Good health ,nervous system diseases ,respiratory tract diseases ,medicine.anatomical_structure ,Cross-Sectional Studies ,030228 respiratory system ,Cohort ,Female ,Life study ,business ,030217 neurology & neurosurgery - Abstract
Background For some patients, Continuous Positive Airway Pressure (CPAP) remains an uncomfortable therapy despite the constant development of technological innovations. To date, no real life study has investigated the relationship between mask related side-effects (MRSEs) and CPAP-non-adherence (defined as Methods The InterfaceVent-CPAP study is a prospective real-life cross-sectional study conducted in an apneic adult cohort undergoing at least 3 months of CPAP with unrestricted mask-access (34 different masks). MRSEs were evaluated using visual-analogue-scales, CPAP-data using CPAP-software, sleepiness using ESS. Results 1484 patients were included in the analysis (72.2% male, median age 67 years (IQ25–75: 60–74), initial Apnea–Hypopnea-Index (AHI) of 39 (31–56)/h, residual AHIflow was 1.9 (0.9–4) events/h), CPAP-treatment lasted 4.4 (2.0–9.7) years, CPAP-usage was 6.8 (5.5–7.8) h/day, the prevalence of CPAP-non-adherence was 8.6%, and the prevalence of RES was 16.17%. Leak-related side-effects were the most prevalent side-effects (patient-reported leaks concerned 75.4% of responders and had no correlation with CPAP-reported-leaks). Multivariable logistic regression analyses evaluating explanatory-variable (demographic data, device/mask data and MRSEs) effects on variables-of-interest (CPAP-non-adherence and RES), indicated for patient-MRSEs significant associations between: (i) CPAP-non-adherence and dry-mouth (p = 0.004); (ii) RES and patient-reported leaks (p = 0.007), noisy mask (p Conclusion In long-term CPAP-treated patients, leak-related side-effects remain the most prevalent side-effects, but patient-reported leaks cannot be predicted by CPAP-reported-leaks. Patient-MRSEs can be independently associated with CPAP-non-adherence and RES, thus implying a complementary role for MRSE questionnaires alongside CPAP-device-reported-data for patient monitoring. Trial registration InterfaceVent is registered with ClinicalTrials.gov (NCT03013283).
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- 2021
43. Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume!
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Alain Palot, Stefania Redolfi, Arnaud Bourdin, Claudio Rabec, M. Georges, Carole Philippe, Erika Nogue, Dany Jaffuel, Jean-Pierre Mallet, Nicolas Molinari, Carey M. Suehs, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Adhésion et Inflammation (LAI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Institut Montpelliérain Alexander Grothendieck (IMAG), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and MORNET, Dominique
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Male ,Cardiac output ,030204 cardiovascular system & hematology ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Tidal volume ,0302 clinical medicine ,Lead (electronics) ,2. Zero hunger ,Sleep Apnea, Obstructive ,Ejection fraction ,Continuous Positive Airway Pressure ,Setting ,3. Good health ,embryonic structures ,Breathing ,Cardiology ,Female ,medicine.symptom ,medicine.medical_specialty ,animal structures ,Adaptive servo-ventilation ,03 medical and health sciences ,Sleep Apnea Syndromes ,Internal medicine ,Hyperventilation ,Pressure ,medicine ,Humans ,Sleep-disordered breathing ,Aged ,lcsh:RC705-779 ,business.industry ,Research ,lcsh:Diseases of the respiratory system ,Respiration, Artificial ,Sleepdisordered breathing ,Cardiopathy ,Cross-Sectional Studies ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cluster ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Minute volume ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Pulmonary Ventilation ,business ,Body mass index ,Respiratory minute volume ,Follow-Up Studies - Abstract
Backgrounds To explain the excess cardiovascular mortality observed in the SERVE-HF study, it was hypothesized that the high-pressure ASV default settings used lead to inappropriate ventilation, cascading negative consequences (i.e. not only pro-arrythmogenic effects through metabolic/electrolyte abnormalities, but also lower cardiac output). The aims of this study are: i) to describe ASV-settings for long-term ASV-populations in real-life conditions; ii) to describe the associated minute-ventilations (MV) and therapeutic pressures for servo-controlled-flow versus servo-controlled-volume devices (ASV-F Philips®-devices versus ASV-V ResMed®-devices). Methods The OTRLASV-study is a cross-sectional, 5-centre study including patients who underwent ASV-treatment for at least 1 year. The eight participating clinicians were free to adjust ASV settings, which were compared among i) initial diagnosed sleep-disordered-breathing (SBD) groups (Obstructive-Sleep-Apnea (OSA), Central-Sleep-Apnea (CSA), Treatment-Emergent-Central-Sleep-Apnea (TECSA)), and ii) unsupervised groups (k-means clusters). To generate these clusters, baseline and follow-up variables were used (age, sex, body mass index (BMI), initial diagnosed Obstructive-Apnea-Index, initial diagnosed Central-Apnea-Index, Continuous-Positive-Airway-Pressure used before ASV treatment, presence of cardiopathy, and presence of a reduced left-ventricular-ejection-fraction (LVEF)). ASV-data were collected using the manufacturer’s software for 6 months. Results One hundred seventy-seven patients (87.57% male) were analysed with a median (IQ25–75) initial Apnea-Hypopnea-Index of 50 (38–62)/h, an ASV-treatment duration of 2.88 (1.76–4.96) years, 61.58% treated with an ASV-V. SDB groups did not differ in ASV settings, MV or therapeutic pressures. In contrast, the five generated k-means clusters did (generally described as follows: (C1) male-TECSA-cardiopathy, (C2) male-mostly-CSA-cardiopathy, (C3) male-mostly-TECSA-no cardiopathy, (C4) female-mostly-elevated BMI-TECSA-cardiopathy, (C5) male-mostly-OSA-low-LVEF). Of note, the male-mostly-OSA-low-LVEF-cluster-5 had significantly lower fixed end-expiratory-airway-pressure (EPAP) settings versus C1 (p = 0.029) and C4 (p = 0.007). Auto-EPAP usage was higher in the male-mostly-TECSA-no cardiopathy-cluster-3 versus C1 (p = 0.006) and C2 (p p = 0.002) and ASV-V (p Conclusions Real-life ASV settings are associated with combinations of baseline and follow-up variables wherein cardiological variables remain clinically meaningful. At the patient level, a hyperventilation risk exists regardless of cluster or ASV-monitoring type, spotlighting a future role of MV-telemonitoring in the interest of patient-safety. Trial registration The OTRLASV study was registered on ClinicalTrials.gov (Identifier: NCT02429986). 1 April 2015.
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- 2020
44. An expert statment on clinical considerations before treating NTM lung infection
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Nicolas Veziris, Margot Drevait, Fatma Tritar, Emilie Catherinot, Maria Cristina Patrizi, Zeina Aoun, Jean Francois Bervar, Vincent Bouix, Bruno Crestani, François-Xavier Blanc, Arnaud Bourdin, Stéphane Jouneau, Cristina Audoly, Anne Bergeron, Massongo Massongo, Léa Colombain, Thomas Maitre, Jean Louis Couderc, Cécile Toper, Magali Dupuy Grasset, Gaëtan Deslée, Jean Francois Boitiaux, Raphaël Chiron, A. Prevotat, Benoit Douvry, Diane Bouvry, Annabelle Payet, Claire Andrejak, Jean Pierre Mallet, Marlène Murris Espin, Gérard Chatté, Wouter Hoefsloot, Frédéric Schlemmer, Mallorie Kerjouan, Jacques Cadranel, Pauline Pradere, Christophe Rogé, Sylvie Leroy, L. Slim, Damien Basille, Amira Benattia, Julien Crouzet, Hôpital Lapeyronie [Montpellier] (CHU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Radboud university [Nijmegen], Saint Joseph Medical Center [Beirut], Hôpital Saint-Joseph [Marseille], CHU Amiens-Picardie, CHU Cochin [AP-HP], CHU Saint Louis [APHP], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier René Dubos [Pontoise], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Centre Hospitalier Saint Jean de Perpignan, Service de pneumologie [Hôpital Foch], Hôpital Foch [Suresnes], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre Hospitalier Universitaire de Reims (CHU Reims), CHI Créteil, CHU Limoges, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Hôpital Central de Yaoundé, CHU Toulouse [Toulouse], CHU Sud Saint Pierre [Ile de la Réunion], Groupe hospitalier Paris Saint-Joseph - Hôpital, CH Morlaix, CHU Henri Mondor, Centre Hospitalier Alès-Cévennes (CHAC), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Unité de Virologie clinique et fondamentale (UVCF), Hopital Saint-Louis [AP-HP] (AP-HP), Clinique de pneumologie [CHRU Lille], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche en Chimie Moléculaire (CRCM), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Hôpital Abderrahmen Mami, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Radboud University [Nijmegen], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Henri Mondor [Créteil], and Unité de recherche de l'institut du thorax (ITX-lab)
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medicine.medical_specialty ,business.industry ,[SDV]Life Sciences [q-bio] ,Lung infection ,education ,Treatments ,Delphi method ,Subject (documents) ,Computer-assisted web interviewing ,3. Good health ,Pulmonology ,Family medicine ,Internal medicine ,medicine ,Treatment decision making ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
Objective: There are a number of factors that go into a recommendation to treat non-tuberculous mycobacterial lung infection (NTM-LI). The purpose of the study is to validate consensus recommendations on clinical considerations before treating a NTM-LI. Methods: We engaged respiratory physicians of the "Mycobacterioses" working group, part of the research and teaching group in pulmonology and infectious diseases (GREPI), on behalf of the SPLF (Societe de Pneumologie de Langue Francaise) in a Delphi survey concerning three areas of interest for physicians before they had to decide to treat (Diagnosis, Definition of the level of severity and Clinical assessment before deciding to treat) in order to create a decision algorithm. Each assertion was subjected to rating and free comments by these experts via an online questionnaire. The scores were weighted by the number of patients seen each year by the experts. The assertions having obtained a weighted average greater than 9/10 were validated. Otherwise they were subject to re-evaluation during round 2 until reaching 9/10. Results: A total of 37 experts responded. At first round, 9/38 assertions obtained a strong agreement (median ≥7 and 80% of responses >7). Other assertions from all domains, in particular the definition of the level of severity, were revised and new assertions added for submission to scoring in round 2. Fifty-one assertions were finally assessed. Agreement was strong in 78% of the assertions (40/51); moderate in 22% (11/51). There was no disagreement. Conclusion: We obtained a consensus from physicians about clinical considerations before deciding to treat NTM-LI and we propose a decision algorithm to guide a treatment decision.
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- 2020
45. Quantum Confinement of Dirac Quasiparticles in Graphene Patterned with Sub‐Nanometer Precision
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Eva Cortés-del Río, Ivan Brihuega, José M. Gómez-Rodríguez, Pierre Mallet, Joaquín Fernández-Rossier, Jean-Yves Veuillen, Jose L. Lado, Héctor González-Herrero, Universidad Autonoma de Madrid (UAM), Nano-Electronique Quantique et Spectroscopie (QuNES), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Aalto University, International Iberian Nanotechnology Laboratory (INL), Universidad de Alicante. Departamento de Física Aplicada, and Grupo de Nanofísica
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Materials science ,Física de la Materia Condensada ,Band gap ,Dirac (software) ,FOS: Physical sciences ,Physics::Optics ,02 engineering and technology ,Electron ,010402 general chemistry ,01 natural sciences ,Atomic manipulation ,law.invention ,symbols.namesake ,law ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,Physics::Atomic and Molecular Clusters ,General Materials Science ,Scanning tunneling microscopy ,ComputingMilieux_MISCELLANEOUS ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter::Other ,Graphene ,business.industry ,Graphene quantum dots ,Mechanical Engineering ,Nanopatterning ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Dirac fermion ,Mechanics of Materials ,Quantum dot ,Quasiparticle ,symbols ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Optoelectronics ,Scanning tunneling microscope ,0210 nano-technology ,business - Abstract
Quantum confinement of graphene Dirac-like electrons in artificially crafted nanometer structures is a long sought goal that would provide a strategy to selectively tune the electronic properties of graphene, including bandgap opening or quantization of energy levels However, creating confining structures with nanometer precision in shape, size and location, remains as an experimental challenge, both for top-down and bottom-up approaches. Moreover, Klein tunneling, offering an escape route to graphene electrons, limits the efficiency of electrostatic confinement. Here, a scanning tunneling microscope (STM) is used to create graphene nanopatterns, with sub-nanometer precision, by the collective manipulation of a large number of H atoms. Individual graphene nanostructures are built at selected locations, with predetermined orientations and shapes, and with dimensions going all the way from 2 nanometers up to 1 micron. The method permits to erase and rebuild the patterns at will, and it can be implemented on different graphene substrates. STM experiments demonstrate that such graphene nanostructures confine very efficiently graphene Dirac quasiparticles, both in zero and one dimensional structures. In graphene quantum dots, perfectly defined energy band gaps up to 0.8 eV are found, that scale as the inverse of the dots linear dimension, as expected for massless Dirac fermions, Main Manuscript and Supporting Information
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- 2020
46. Bound Hole States Associated to Individual Vanadium Atoms Incorporated into Monolayer WSe 2
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Matthieu Jamet, Pierre Mallet, Hanako Okuno, H. Boukari, Jean-Yves Veuillen, Florian Chiapello, Nano-Electronique Quantique et Spectroscopie (QuNES), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratory of Atomistic Simulation (LSIM), Modélisation et Exploration des Matériaux (MEM), Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Nanophysique et Semiconducteurs (NPSC), SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), ANR-15-CE24-0017,J2D,Jonctions ultrafines réalisées par empilement de matériaux 2D: nouveaux constituents de base pour l'électronique(2015), ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018), Nano-Electronique Quantique et Spectroscopie (NEEL - QuNES), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Nanophysique et Semiconducteurs (NEEL - NPSC)
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Condensed Matter - Materials Science ,Materials science ,Magnetic moment ,Dopant ,Magnetism ,Doping ,General Physics and Astronomy ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,01 natural sciences ,Molecular physics ,3. Good health ,law.invention ,Condensed Matter::Materials Science ,law ,0103 physical sciences ,Monolayer ,Bound state ,Physics::Atomic and Molecular Clusters ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Scanning tunneling microscope ,010306 general physics ,Spectroscopy - Abstract
Doping a two-dimensional semiconductor with magnetic atoms is a possible route to induce magnetism in the material. We report on the atomic structure and electronic properties of monolayer WSe$_2$ intentionally doped with vanadium atoms by means of scanning transmission electron microscopy and scanning tunneling microscopy and spectroscopy. Most of the V atoms incorporate at W sites. These V$_W$ dopants are negatively charged, which induces a localized bound state located 140 meV above the valence band maximum. The overlap of the electronic potential of two charged V$_W$ dopants generates additional in-gap states. Eventually, the negative charge may suppress the magnetic moment on the V$_W$ dopants., Comment: 12 pages, 4 figures
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- 2020
47. Careful consideration of the bleeding caused by transbronchial lung cryobiopsies
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Jean Pierre Mallet, Carey M. Suehs, Isabelle Vachier, Kheira Hireche, Jean Philippe Berthet, Paul Reynaud, Stefano Nava, Nicolas Molinari, Micaela Romagnoli, Anne Sophie Gamez, Arnaud Bourdin, Bourdin A., Romagnoli M., Gamez A.S., Hireche K., Berthet J.P., Mallet J.P., Vachier I., Nava S., Reynaud P., Molinari N., Suehs C., Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Service de chirurgie thoracique et cardio-vasculaire, and Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Université de Montpellier (UM)
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung ,business.industry ,Hemorrhage ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,respiratory system ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Lung surface ,respiratory tract diseases ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030228 respiratory system ,medicine ,Humans ,030212 general & internal medicine ,Radiology ,business ,Lung Diseases, Interstitial ,ComputingMilieux_MISCELLANEOUS ,Lung function ,Human - Abstract
Lung surface photos show wounds/haemorrhages caused by transbronchial lung cryobiopsy (TBLC). TBLC bleeding can extensively soil airways with consequences for lung function, stressing the need for bleeding prevention and more research via registries.https://bit.ly/34wWAeR
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- 2020
48. Atomic-scale control of graphene magnetism using hydrogen atoms
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Carlos Salgado, Pierre Mallet, Felix Yndurain, Mohamed Moaied, Ivan Brihuega, Jean-Yves Veuillen, José M. Gómez-Rodríguez, Héctor González-Herrero, Miguel M. Ugeda, Juan Jose Palacios, Departamento de Fisica de la Materia Condensada [Madrid] (FMC), Facultad de Ciencas [Madrid], Universidad Autonoma de Madrid (UAM)-Universidad Autonoma de Madrid (UAM), Nano-Electronique Quantique et Spectroscopie (QuNES), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Ikerbasque - Basque Foundation for Science, and CICNanoGUNE
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Hydrogen ,Magnetism ,chemistry.chemical_element ,FOS: Physical sciences ,02 engineering and technology ,01 natural sciences ,Atomic units ,Molecular physics ,law.invention ,Condensed Matter::Materials Science ,law ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,Physics::Atomic and Molecular Clusters ,Physics::Atomic Physics ,010306 general physics ,ComputingMilieux_MISCELLANEOUS ,Condensed Matter::Quantum Gases ,Condensed Matter - Materials Science ,Multidisciplinary ,Condensed matter physics ,Magnetic moment ,Condensed Matter - Mesoscale and Nanoscale Physics ,Graphene ,Materials Science (cond-mat.mtrl-sci) ,Fermi energy ,Hydrogen atom ,021001 nanoscience & nanotechnology ,3. Good health ,chemistry ,[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] ,Scanning tunneling microscope ,0210 nano-technology - Abstract
Hydrogen atom makes graphene magnetic Graphene has many extraordinary mechanical and electronic properties, but it's not magnetic. To make it so, the simplest strategy is to modify its electronic structure to create unpaired electrons. Researchers can do that by, for example, removing individual carbon atoms or adsorbing hydrogen onto graphene. This has to be done in a very controlled way because of a peculiarity of the graphene's crystal lattice, which consists of two sublattices. Gonzales-Herrero et al. deposited a single hydrogen atom on top of graphene and used scanning tunneling microscopy to detect magnetism on the sublattice lacking the deposited atom (see the Perspective by Hollen and Gupta). Science , this issue p. 437 ; see also p. 415
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- 2020
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49. Brain metabolism and related connectivity in patients with acrophobia treated by virtual reality therapy: an 18F-FDG PET pilot study sensitized by virtual exposure
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Emmanuelle Reynaud, Antoine Verger, Stéphanie Khalfa, Jean-Marie Pergandi, Pierre Mallet, Daniel Mestre, Eric Malbos, Eric Guedj, Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut d'Administration des Entreprises (IAE) - Aix-en-Provence (AMU IAE), Aix Marseille Université (AMU), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Neurosciences de la Timone (INT), Service Central de Biophysique et de Médecine Nucléaire, Hôpital de la Timone [CHU - APHM] (TIMONE), Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS)
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,lcsh:R895-920 ,Statistical parametric mapping ,Virtual reality exposure therapy ,030218 nuclear medicine & medical imaging ,18f fdg pet ,Virtual Reality Exposure Therapy ,03 medical and health sciences ,Metabolic connectivity ,0302 clinical medicine ,Physical medicine and rehabilitation ,Acrophobia ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,ComputingMilieux_MISCELLANEOUS ,business.industry ,Pet imaging ,medicine.disease ,Virtual reality therapy ,PET ,Concomitant ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030217 neurology & neurosurgery - Abstract
International audience; Background: The aim of this pilot study is to investigate the impact of virtual reality exposure therapy (VRET) on brain metabolism and connectivity. Eighteen patients with acrophobia were assessed by an F-18-FDG PET scan sensitized by virtual exposure before treatment, and nine of them were assessed again after eight sessions of VRET. Statistical Parametric Mapping was used to study the correlations between metabolism and pretherapeutic clinical scores and to compare metabolism before and after VRET (p voxel < 0.005, corrected for cluster volume). Metabolic connectivity was evaluated through interregional correlation analysis. Results: Before therapy, a positive correlation was found between scores on the behavioural avoidance test and left occipital metabolism (BA17-18). After VRET, patients presented increased metabolism in the left frontal superior gyri and the left precentral gyrus, which showed increased metabolic connectivity with bilateral occipital areas (BA17-18-19), concomitant with clinical recovery. Conclusions: This study highlights the exciting opportunity to use brain PET imaging to investigate metabolism during virtual exposure and reports the involvement of the visual-motor control system in the treatment of acrophobia by VRET.
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- 2018
50. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016
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Henri-Pierre Mallet, Pauline Brindel, Teheipuaura Mariteragi-Helle, Gilles Dupuis, Tu-Xuan Nhan, Delphine Lutringer-Magnin, Timothée Dub, Céline Gurry, Lorenzo Subissi, P Barboza, Judith R. Glynn, Didier Musso, David Baud, Van-Mai Cao-Lormeau, Marine Giard, Eric J. Nilles, Marianne Besnard, Angela Merianos, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)
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Male ,0301 basic medicine ,Pediatrics ,congenital Zika syndrome ,Epidemiology ,French Polynesia ,lcsh:Medicine ,Zika virus ,Child Development ,0302 clinical medicine ,Zika Virus Infection during Pregnancy and Early Childhood Development, French Polynesia, 2013–2016 ,Pregnancy ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Odds Ratio ,Public Health Surveillance ,030212 general & internal medicine ,Early childhood ,Geography, Medical ,Pregnancy Complications, Infectious ,Child ,biology ,Middle Aged ,early childhood development ,3. Good health ,Infectious Diseases ,Maternal Exposure ,In utero ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Neurologic abnormalities ,child health ,Female ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,Pacific Islands ,History, 21st Century ,Polynesia ,Child health ,Congenital Abnormalities ,lcsh:Infectious and parasitic diseases ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,Development assessment ,viruses ,lcsh:RC109-216 ,Intrauterine infection ,business.industry ,Research ,lcsh:R ,Infant ,Zika Virus ,Zika virus infection ,medicine.disease ,biology.organism_classification ,Patient Outcome Assessment ,Cross-Sectional Studies ,030104 developmental biology ,Case-Control Studies ,business - Abstract
International audience; Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed.
- Published
- 2018
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