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811 results on '"Piersma, Aldert H."'

11. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Author

Fritsche, Ellen, Grandjean, Philippe, Crofton, Kevin M, Aschner, Michael, Goldberg, Alan, Heinonen, Tuula, Hessel, Ellen VS, Hogberg, Helena T, Bennekou, Susanne Hougaard, Lein, Pamela J, Leist, Marcel, Mundy, William R, Paparella, Martin, Piersma, Aldert H, Sachana, Magdalini, Schmuck, Gabriele, Solecki, Roland, Terron, Andrea, Monnet-Tschudi, Florianne, Wilks, Martin F, Witters, Hilda, Zurich, Marie-Gabrielle, and Bal-Price, Anna

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Pediatric, Neurosciences, Biotechnology, Neurological, Age Factors, Animal Testing Alternatives, Animals, Brain, Consensus, Diffusion of Innovation, Humans, Neurons, Neurotoxicity Syndromes, Policy Making, Reproducibility of Results, Risk Assessment, Stakeholder Participation, Toxicity Tests, Toxicology, Developmental neurotoxicity, In vitro testing, Regulatory purposes, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences
Abstract

This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential. Closing this data gap with the current test guideline approach is not feasible, because the in vivo bioassays are far too resource-intensive concerning time, money and number of animals. A variety of in vitro methods are now available, that have the potential to close this data gap by permitting mode-of-action-based DNT testing employing human stem cells-derived neuronal/glial models. In vitro DNT data together with in silico approaches will in the future allow development of predictive models for DNT effects. The ultimate application goals of these new approach methods for DNT testing are their usage for different regulatory purposes.

Published
2018

14. Safer chemicals using less animals: kick-off of the European ONTOX project

Author

Vinken, Mathieu, Benfenati, Emilio, Busquet, François, Castell, José, Clevert, Djork-Arné, de Kok, Theo M., Dirven, Hubert, Fritsche, Ellen, Geris, Liesbet, Gozalbes, Rafael, Hartung, Thomas, Jennen, Danyel, Jover, Ramiro, Kandarova, Helena, Kramer, Nynke, Krul, Cyrille, Luechtefeld, Thomas, Masereeuw, Rosalinde, Roggen, Erwin, Schaller, Stephan, Vanhaecke, Tamara, Yang, Chihae, and Piersma, Aldert H.

Published
2021
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16. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Author

Aschner, Michael, Ceccatelli, Sandra, Daneshian, Mardas, Fritsche, Ellen, Hasiwa, Nina, Hartung, Thomas, Hogberg, Helena T, Leist, Marcel, Li, Abby, Mundi, William R, Padilla, Stephanie, Piersma, Aldert H, Bal-Price, Anna, Seiler, Andrea, Westerink, Remco H, Zimmer, Bastian, and Lein, Pamela J

Subjects
Agricultural, Veterinary and Food Sciences, Biomedical and Clinical Sciences, Health Sciences, Pediatric, Neurosciences, Animal Testing Alternatives, Animals, Congresses as Topic, Drug Evaluation, Preclinical, Female, Hazardous Substances, Humans, Male, Neurons, Neurotoxicity Syndromes, Neurotoxins, Pregnancy, Prenatal Exposure Delayed Effects, Toxicity Tests, neurotoxicity, specificity, test development, AOP, validation, Agricultural and Veterinary Sciences, Medical and Health Sciences, Toxicology, Agricultural, veterinary and food sciences, Biomedical and clinical sciences, Health sciences
Abstract

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to result from the modulation of fundamental neurodevelopmental processes (such as neuronal differentiation, precursor cell migration or neuronal network formation) by chemicals, the first generation of alternative DNT tests target these processes. The advantage of such types of assays is that they capture toxicants with multiple targets and modes-of-action. Moreover, the processes modelled by the assays can be linked to toxicity endophenotypes, i.e., alterations in neural connectivity that form the basis for neurofunctional deficits in man. The authors of this review convened in a workshop to define criteria for the selection of positive/negative controls, to prepare recommendations on their use, and to initiate the setup of a directory of reference chemicals. For initial technical optimization of tests, a set of > 50 endpoint-specific control compounds was identified. For further test development, an additional "test" set of 33 chemicals considered to act directly as bona fide DNT toxicants is proposed, and each chemical is annotated to the extent it fulfills these criteria. A tabular compilation of the original literature used to select the test set chemicals provides information on statistical procedures, and toxic/non-toxic doses (both for pups and dams). Suggestions are provided on how to use the > 100 compounds (including negative controls) compiled here to address specificity, adversity and use of alternative test systems.

Published
2017

24. Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Author

Buesen, Roland, Chorley, Brian N., da Silva Lima, Beatriz, Daston, George, Deferme, Lize, Ebbels, Timothy, Gant, Timothy W., Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H., Sauer, Ursula G., Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut E., Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J.M., Worth, Andrew, Yauk, Carole, and Poole, Alan

Published
2017
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28. Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14–16 May 2014

Author

Solecki, Roland, Rauch, Martina, Gall, Andrea, Buschmann, Jochen, Clark, Ruth, Fuchs, Antje, Kan, Haidong, Heinrich, Verena, Kellner, Rupert, Knudsen, Thomas B., Li, Weihua, Makris, Susan L., Ooshima, Yojiro, Paumgartten, Francisco, Piersma, Aldert H., Schönfelder, Gilbert, Oelgeschläger, Michael, Schaefer, Christof, Shiota, Kohei, Ulbrich, Beate, Ding, Xuncheng, and Chahoud, Ibrahim

Published
2015
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30. A perspective on the developmental toxicity of inhaled nanoparticles

Author

Hougaard, Karin Sørig, Campagnolo, Luisa, Chavatte-Palmer, Pascale, Tarrade, Anne, Rousseau-Ralliard, Delphine, Valentino, Sarah, Park, Margriet V.D.Z., de Jong, Wim H., Wolterink, Gerrit, Piersma, Aldert H., Ross, Bryony L., Hutchison, Gary R., Hansen, Jitka Stilund, Vogel, Ulla, Jackson, Petra, Slama, Rémy, Pietroiusti, Antonio, and Cassee, Flemming R.

Published
2015
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45. Applying ʼomics technologies in chemicals risk assessment: Report of an ECETOC workshop

Author

Buesen, Roland, Chorley, Brian N., da Silva Lima, Beatriz, Daston, George, Deferme, Lize, Ebbels, Timothy, Gant, Timothy W., Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H., Sauer, Ursula G., Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut E., Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J.M., Worth, Andrew, Yauk, Carole, and Poole, Alan

Published
2017
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