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4. Non-AIDS Lipodystrophy Syndrome

Author

Enzi, Giuliano, Busetto, Luca, Sergi, Giuseppe, Pigozzo, Sabrina, Mantovani, Giovanni, editor, Anker, Stefan D., editor, Inui, Akio, editor, Morley, John E., editor, Fanelli, Filippo Rossi, editor, Scevola, Daniele, editor, Schuster, Michael W., editor, and Yeh, Shing-Shing, editor

Published
2006
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5. Diabetes Affects Antibody Response to SARS-CoV-2 Vaccination in Older Residents of Long-Term Care Facilities: Data From the GeroCovid Vax Study

Author

Enrico, Virgilio, Caterina, Trevisan, Angela, Abbatecola, Alba, Malara, Annapina, Palmieri, Giorgio, Fedele, Paola, Stefanelli, Pasqualina, Leone, Ilaria, Schiavoni, Stefania, Maggi, Stefano, Volpato, Raffaele Antonelli Incalzi, Graziano, Onder, the GeroCovid Vax Working Group, Angela Marie Abbatecola, Domenico, Andrieri, Francesca, Arenare, Viviana, Bagalà, Baldovin, Tatjana, Riccardo, Bernardi, Alessandra, Bianchi, Paola, Bianchi, Raffaella, Bisceglia, Ivan, Bissoli, Fabio, Bontempi, Gilda, Borselli, Luigi, Bottaro, Elisa, Bottoni, Silvia, Brandi, Claudio, Bravin, Maria Adele Buizza, Carmine, Cafariello, Alessia Maria Calabrese, Valeria, Calsolaro, Marta, Canepa, Carla, Capasso, Mariagrazia, Capuano, Sebastiano, Capurso, Gabriele, Carbone, Marialudovica, Carducci, Silvia, Carino, Nicoletta, Cattaneo, Francesco, Ceravolo, Maria Angelica Dorotea Chiesara, Danila, Clerici, Pierpaolo, Clerici, Coin, Alessandra, Vieri, Collacchioni, Mauro, Colombo, Michela, Compiano, Giuseppina, Costanza, Giovanna, Crupi, Roberta, Cucunato, Manuela Marina D'Abramo, Emilia, D'Agostino, Ferdinando, D'Amico, Antonio De Simone, Stefania Del Vecchio, Maria, Deleo, Annalaura, Dell'Armi, Tommasina Di Brango, Anna Di Lonardo, Maria Raffaella Di Nanno, Babette, Dijk, Luisa, Elmo, Marisa, Ferraro, Christian, Ferro, Claudia, Fiorucci, Francesca, Fortunato, Pasquale, Froncillo, Domenico, Galasso, Nicola, Galdiero, Caterina, Galdiero, Stefania, Gallo, Pier Paolo Gasbarri, Maria Grazia Gennai, Giuliana Ghiselli Ricci, Elisa, Giribaldi, Carmen, Godeanu, Samuele, Gommaraschi, Roberta, Granata, Giada Ida Greco, Angela, Greco, Antonio, Grillo, Gianbattista, Guerrini, Mauro, Guglielmo, Labjona, Haxhiaj, Claudio Giuseppe Iacovella, Marina, Indino, Valerio Alex Ippolito, David, Kanah, Liudmila, Kountsevich, Jovan, Leci, Limongi, Federica, Agata, Lipari, Vincenzo, Longo, Leonarda, Maltese, Maria, Marotta, Giuseppe, Mazzarella, Hior, Melnik, Pasquale, Minchella, Paolo, Moneti, Fabio, Monzani, Walter, Morandotti, Francesco, Morelli, Maria Grazia Mortola, Marianna, Noale, Chukwuma, Okoye, Patrizia, Orlanducci, Barbara, Paganelli, Michele, Pagano, Nicola, Pagano, Raffaele, Palladino, Magda, Palumeri, Simone, Paolini, Raimondo, Paternò, Angela, Pavan, Loris, Pelucchi, Agostino, Perri, Francesco, Perticone, Rosanna, Pesce, Pigozzo, Sabrina, Francesco, Pili, Rosa, Prato, Rosanna, Pullia, Ahmad Amedeo Qasem, Francesco Raffaele Addamo, Cecilia, Raffaelli, Vincenzo, Restivo, Michela Fernanda Rigon, Franco, Romagnoni, Carmine, Romaniello, Valentina, Romano, Maria Cristina Ruberto, Marcello, Russo, Bruno, Sala, Sara, Sambo, Maria Concetta Sciurti, Antonietta, Scriva, Luca, Secchi, Vincenzo, Settembrini, Federica, Sirianni, Deborah, Spaccaferro, Fausto, Spadea, Manuela, Stefanelli, Brunella, Stelitano, Stefania, Stringhini, Andrea, Tarsitano, Camilla, Terziotti, Rita, Ursino, Giovanni, Veneziano, Maria Teresa Vigliotta, Marco, Vignati, Eva, Vignola, Maria, Visconti, Susanna, Vozzi, and Sabrina, Zaccone

Subjects
Type 2 diabetes, antibody response, SARS-CoV-2 vaccination, long-term care facilities (LTCFs), older adults, Advanced and Specialized Nursing, SARS-CoV-2 vaccination, Endocrinology, Diabetes and Metabolism, Internal Medicine, Type 2 diabetes, long-term care facilities (LTCFs), antibody response, older adults
Abstract

OBJECTIVE Type 2 diabetes may affect the humoral immune response after vaccination, but data concerning coronavirus disease 19 (COVID-19) vaccines are scarce. We evaluated the impact of diabetes on antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in older residents of long-term care facilities (LTCFs) and tested for differences according to antidiabetic treatment. RESEARCH DESIGN AND METHODS For this analysis, 555 older residents of LTCFs participating in the GeroCovid Vax study were included. SARS-CoV-2 trimeric S immunoglobulin G (anti-S IgG) concentrations using chemiluminescent assays were tested before the first dose and after 2 and 6 months. The impact of diabetes on anti-S IgG levels was evaluated using linear mixed models, which included the interaction between time and presence of diabetes. A second model also considered diabetes treatment: no insulin therapy (including dietary only or use of oral antidiabetic agents) and insulin therapy (alone or in combination with oral antidiabetic agents). RESULTS The mean age of the sample was 82.1 years, 68.1% were women, and 25.2% had diabetes. In linear mixed models, presence of diabetes was associated with lower anti-S IgG levels at 2 (β = −0.20; 95% CI −0.34, −0.06) and 6 months (β = −0.22; 95% CI −0.37, −0.07) after the first vaccine dose. Compared with those without diabetes, residents with diabetes not using insulin had lower IgG levels at 2- and 6-month assessments (β = −0.24; 95% CI −0.43, −0.05 and β = −0.30; 95% CI −0.50, −0.10, respectively), whereas no differences were observed for those using insulin. CONCLUSIONS Older residents of LTCFs with diabetes tended to have weaker antibody response to COVID-19 vaccination. Insulin treatment might buffer this effect and establish humoral immunity similar to that in individuals without diabetes.

Published
2022

6. PCSK9 Levels Are Raised in Chronic HCV Patients with Hepatocellular Carcinoma

Author

Fasolato, Silvano, Pigozzo, Sabrina, Pontisso, Patrizia, Angeli, Paolo, Ruscica, Massimiliano, Savarino, Edoardo, De Martin, Sara, Lupo, Maria Giovanna, and Ferri, Nicola

Subjects
PCSK9, lcsh:R, HCV, lcsh:Medicine, virus diseases, cholesterol, hepatocellular carcinoma, Article, digestive system diseases
Abstract

Background: Since emerging evidence suggests a protective role of proprotein convertase subtilisin/kexin type 9 (PCSK9) on hepatitis C virus (HCV) infection, the aim of the present study was to evaluate the correlation between PCSK9 and HCV infection in hepatocellular carcinoma (HCC) patients. Methods: In this retrospective study, PCSK9 levels were evaluated by ELISA, in plasma samples from control (n = 24) and 178 patients diagnosed for HCC, cirrhosis, or chronic hepatitis, either positive or negative for HCV. Results: HCV positive patients (HCV+) presented with higher PCSK9 levels compared to HCV negative individuals (HCV-), 325.2 &plusmn, 117.7 ng/mL and 256.7 &plusmn, 139.5 ng/mL, respectively. This difference was maintained in the presence of HCC, although this disease significantly reduced PCSK9 levels. By univariate analysis, a positive correlation between PCSK9 and HCV viral titer was found, being G2 genotype the most-potent inducer of PCSK9 among other genotypes. This induction was not associated with changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). A negative correlation was also found between PCSK9 levels and liver impairment, assessed by Model for End-Stage Liver Disease (MELD). Finally, a multivariate correlation analysis corrected for age, TC, LDL-C, and sex, demonstrated, in the whole cohort, a positive association between PCSK9 and HCV and a negative with HCC. Conclusions: taken together, our study reveals that HCV raised PCSK9 in both the presence and absence of HCC.

Published
2020
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9. Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long‐term cognitive and functional changes in patients treated with donepezil?

Author

Pamio, Maria V., Trevisan, Caterina, Pigozzo, Sabrina, De Rui, Marina, Devita, Maria, Girardi, Agostino, Manzato, Enzo, Sergi, Giuseppe, and Coin, Alessandra

Subjects
GERIATRIC assessment, ALZHEIMER'S disease, APOLIPOPROTEINS, COGNITION disorders, QUESTIONNAIRES, REGRESSION analysis, DATA analysis software, DONEPEZIL, SINGLE nucleotide polymorphisms, DESCRIPTIVE statistics, GENOTYPES, CYTOCHROME P-450
Abstract

Aim: We investigated the associations of the single‐nucleotide polymorphism rs1080985 of cytochrome P4502D6 (CYP2D6) and the apolipoprotein E (APOE) genotypes with cognitive and functional changes in patients treated with donepezil. Methods: Sixty‐five outpatients with Alzheimer's disease or mixed dementia being treated with donepezil were assessed at baseline and over 27 months. Changes in cognitive status, assessed with the Mini‐Mental State Examination, and in functional status, assessed by the Activities of Daily Living Scale and the Instrumental Activities of Daily Living Scale, were evaluated as a function of CYP2D6 and APOE genotypes by using linear mixed models. Multiplicative interactions between the CYP2D6 and APOE genotypes and time were investigated. Results: Individuals with the mutated CYP2D6 exhibited a slower decline in total Mini‐Mental State Examination scores, orientation, registration, and functional status than those with the wild type. A significant interaction between CYP2D6, APOE, and time was found for changes in the Activities of Daily Living Scale; among the ε4 carriers, those with the mutated CYP2D6 exhibited a slower decline on the Activities of Daily Living Scale than those with the wild type. Conclusion: The CYP2D6 and APOE genotypes may modulate the effectiveness of donepezil on cognitive and functional status. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Influence of serum 25-hydroxyvitamin D levels, fat-free mass, and fat mass on bone density, geometry and strength, in healthy young and elderly adults

Author

Bano, Giulia, primary, Pigozzo, Sabrina, additional, Piovesan, Francesca, additional, Mazzochin, Mattia, additional, Dianin, Marta, additional, Bedogni, Marco, additional, Zaninotto, Martina, additional, Giannini, Sandro, additional, Perissinotto, Egle, additional, Manzato, Enzo, additional, Plebani, Mario, additional, and Sergi, Giuseppe, additional

Published
2018
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15. The effects of the surgical removal of subcutaneous adipose tissue on energy expenditure and adipocytokine concentrations in obese women

Author

Busetto, Luca, primary, Bassetto, Franco, additional, Zocchi, Michele, additional, Zuliani, Francesca, additional, Nolli, Maria Luisa, additional, Pigozzo, Sabrina, additional, Coin, Alessandra, additional, Mazza, Marco, additional, Sergi, Giuseppe, additional, Mazzoleni, Francesco, additional, and Enzi, Giuliano, additional

Published
2008
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18. Non-AIDS Lipodystrophy Syndrome.

Author

Mantovani, Giovanni, Anker, Stefan D., Inui, Akio, Morley, John E., Fanelli, Filippo Rossi, Scevola, Daniele, Schuster, Michael W., Shing-Shing Yeh, Enzi, Giuliano, Busetto, Luca, Sergi, Giuseppe, and Pigozzo, Sabrina

Abstract

Lipodystrophies (LDs) are clinically heterogeneous acquired or inherited disorders characterised by a generalised or regional loss of adipose tissue. Generalised LDs, both inherited and acquired, are associated with peripheral insulin resistance, glucose intolerance or overt diabetes, acanthosis nigricans, dyslipidaemia. Bone demineralisation and polycystic ovary syndrome are also part of these diseases. LDs can be classified as acquired or congenital, and generalised or partial (Table 1). [ABSTRACT FROM AUTHOR]

Published
2006
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