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1. AB1704 INFLUENZA AND PNEUMOCOCCAL VACCINATION COVERAGE AMONG PATIENTS WITH JUVENILE IMMUNE-MEDIATED RHEUMATIC DISEASES: PRELIMINARY RESULTS OF A MULTICENTER CROSS-SECTIONAL STUDY

Author

Faria Moreira Gomes Tavares, A. C., primary, Appenzeller, S., additional, Marini, R., additional, Fraga, M., additional, Dos Santos, M. C., additional, Terreri, M. T., additional, Pantoja de Moraes, A. J., additional, Robazzi, T. C., additional, Garcia Cunha, A. L., additional, Schinzel, V., additional, Do Prado, R., additional, Rodrigues, M., additional, Muzzi Torres Lage, L., additional, Santos Macedo, L., additional, Rotsen Correa, T., additional, Salviato Pileggi, G., additional, and Kakehasi, A. M., additional

Published
2024
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2. Construction techniques and performances of a full-size prototype Micromegas chamber for the ATLAS muon spectrometer upgrade

Author

Alexopoulos, T., Alviggi, M., Antonelli, M., Anulli, F., Arcangeletti, C., Bagnaia, P., Baroncelli, A., Beretta, M., Bini, C., Bortfeldt, J., Calabrò, D., Canale, V., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Ciapetti, G., Amico, V. D', De Fazio, B., Del Gaudio, M., Di Donato, C., Di Nardo, R., Uffizi, D. D', Farina, E., Ferrari, R., Freddi, A., Gatti, C., Gaudio, G., Gkountoumis, P., Gorini, E., Gravili, F., Gigli, S. Guelfo, Iakovidis, G., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Karentzos, E., Koulouris, A., Kourkoumeli-Charalampidi, A., Lacava, F., Lanza, A., La Rotonda, L., Lauciani, S., Luminari, L., Maccarrone, G., Maltezos, S., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Moschovakos, P., Ntekas, K., Palazzo, S., Paruzza, G., Petrucci, F., Pezzotti, L., Pileggi, G., Policicchio, A., Pontoriere, G., Ponzio, B., Romano, E., Romano, V., Roscilli, L., Rovelli, G., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Turco, P., Vanadia, M., Vannicola, D., Vassileva, T., Vecchio, V., Vercellati, F., and Zullo, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A full-size prototype of a Micromegas precision tracking chamber for the upgrade of the ATLAS detector at the LHC Collider has been built between October 2015 and April 2016. This paper describes in detail the procedures used in constructing the single modules of the chamber in various INFN laboratories and the final assembly at the Laboratori Nazionali di Frascati (LNF). Results of the chamber exposure to the CERN SPS/H8 beam line in June 2016 are also presented. The performances achieved in the construction and the results of the test beam are compared with the requirements, which are imposed by the severe environment during the data-taking of the LHC foreseen for the next years., Comment: Contact editors: G. Mancini, A. Kourkoumeli-Charalampidi

Published
2018

3. Construction and test of the SM1 type Micromegas chambers for the upgrade of the ATLAS forward muon spectrometer

Author

Agarwala, J., Alviggi, M.G., Antonelli, M., Anulli, F., Arcangeletti, C., Auricchio, S., Bagnaia, P., Bariani, S., Baroncelli, A., Bashta, I., Bauce, M., Beretta, M., Bini, C., Calabró, D., Camerlingo, M.T., Canale, V., Capitolo, E., Capponi, M., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Chiarella, V., Ciapetti, G., D’Amico, V., De Cecco, S., De Fazio, B., Del Gaudio, M., Di Donato, C., Di Nardo, R., D’Uffizi, D., Farilla, A., Farina, E., Ferrari, R., Fiore, G., Frattari, G., Freddi, A., Gaudio, G., Gauzzi, P., Giagu, S., Gigli, S., Gnesi, I., Gorini, E., Gravili, F.G., Greco, M., Iaciofano, A., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Ippolito, V., Kourkoumeli Charalampidi, A., Lacava, F., Lalli, E., Lanza, A., Lauciani, S., Laurelli, P., Luminari, L., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Negri, A., Orestano, D., Paruzza, G., Pepe, M., Petruccetti, M., Petrucci, F., Pezzotti, L., Pileggi, G., Pirola, M., Piscitelli, C., Polesello, G., Policicchio, A., Pontoriere, G., Ponzio, B., Primavera, M., Rebuzzi, D., Rimoldi, A., Romano, E., Roscilli, L., Rovelli, G., Russo, V., Sansoni, A., Safai Tehrani, F., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Trattino, P., Tskhadadze, E., Turco, P., Vannicola, D., Vannoli, L., Vassilieva, T., Vecchio, V., Ventura, A., Vercellati, F., Vilucchi, E., Zullo, A., and Zunica, G.

Published
2022
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4. Mu2e Technical Design Report

Author

Bartoszek, L., Barnes, E., Miller, J. P., Mott, J., Palladino, A., Quirk, J., Roberts, B. L., Crnkovic, J., Polychronakos, V., Tishchenko, V., Yamin, P., Cheng, C. -h., Echenard, B., Flood, K., Hitlin, D. G., Kim, J. H., Miyashita, T. S., Porter, F. C., Röhrken, M., Trevor, J., Zhu, R. -Y., Heckmaier, E., Kang, T. I., Lim, G., Molzon, W., You, Z., Artikov, A. M., Budagov, J. A., Davydov, Yu. I., Glagolev, V. V., Simonenko, A. V., Usubov, Z. U., Oh, S. H., Wang, C., Ambrosio, G., Andreev, N., Arnold, D., Ball, M., Bernstein, R. H., Bianchi, A., Biery, K., Bossert, R., Bowden, M., Brandt, J., Brown, G., Brown, H., Buehler, M., Campbell, M., Cheban, S., Chen, M., Coghill, J., Coleman, R., Crowley, C., Deshpande, A., Deuerling, G., Dey, J., Dhanaraj, N., Dinnon, M., Dixon, S., Drendel, B., Eddy, N., Evans, R., Evbota, D., Fagan, J., Feher, S., Fellenz, B., Friedsam, H., Gallo, G., Gaponenko, A., Gardner, M., Gaugel, S., Genser, K., Ginther, G., Glass, H., Glenzinski, D., Hahn, D., Hansen, S., Hartsell, B., Hays, S., Hocker, J. A., Huedem, E., Huffman, D., Ibrahim, A., Johnstone, C., Kashikhin, V., Kashikhin, V. V., Kasper, P., Kiper, T., Knapp, D., Knoepfel, K., Kokoska, L., Kozlovsky, M., Krafczyk, G., Kramp, M., Krave, S., Krempetz, K., Kutschke, R. K., Kwarciany, R., Lackowski, T., Lamm, M. J., Larwill, M., Leavell, F., Leeb, D., Leveling, A., Lincoln, D., Logashenko, V., Lombardo, V., Lopes, M. L., Makulski, A., Martinez, A., McArthur, D., McConologue, F., Michelotti, L., Mokhov, N., Morgan, J., Mukherjee, A., Murat, P., Nagaslaev, V., Neuffer, D. V., Nicol, T., Niehoff, J., Nogiec, J., Olson, M., Orris, D., Ostojic, R., Page, T., Park, C., Peterson, T., Pilipenko, R., Pla-Dalmau, A., Poloubotko, V., Popovic, M., Prebys, E., Prieto, P., Pronskikh, V., Pushka, D., Rabehl, R., Ray, R. E., Rechenmacher, R., Rivera, R., Robotham, W., Rubinov, P., Rusu, V. L., Scarpine, V., Schappert, W., Schoo, D., Stefanik, A., Still, D., Tang, Z., Tanovic, N., Tartaglia, M., Tassotto, G., Tinsley, D., Tschirhart, R. S., Vogel, G., Wagner, R., Wands, R., Wang, M., Werkema, S., White Jr., H. B., Whitmore, J., Wielgos, R., Woods, R., Worel, C., Zifko, R., Ciambrone, P., Colao, F., Cordelli, M., Corradi, G., Dane, E., Giovannella, S., Happacher, F., Luca, A., Miscetti, S., Ponzio, B., Pileggi, G., Saputi, A., Sarra, I., Soleti, R. S., Stomaci, V., Martini, M., Fabbricatore, P., Farinon, S., Musenich, R., Alexander, D., Daniel, A., Empl, A., Hungerford, E. V., Lau, K., Gollin, G. D., Huang, C., Roderick, D., Trundy, B., Brown, D. Na., Ding, D., Kolomensky, Yu. G., Lee, M. J., Cascella, M., Grancagnolo, F., Ignatov, F., Innocente, A., L'Erario, A., Miccoli, A., Maffezzoli, A., Mazzotta, P., Onorato, G., Piacentino, G. M., Rella, S., Rossetti, F., Spedicato, M., Tassielli, G., Taurino, A., Zavarise, G., Hooper, R., Brown, D. No., Djilkibaev, R., Matushko, V., Ankenbrandt, C., Boi, S., Dychkant, A., Hedin, D., Hodge, Z., Khalatian, V., Majewski, R., Martin, L., Okafor, U., Pohlman, N., Riddel, R. S., Shellito, A., de Gouvea, A. L., Cervelli, F., Carosi, R., Di Falco, S., Donati, S., Lomtadze, T., Pezzullo, G., Ristori, L., Spinella, F., Jones, M., Corcoran, M. D., Orduna, J., Rivera, D., Bennett, R., Caretta, O., Davenne, T., Densham, C., Loveridge, P., Odell, J., Bomgardner, R., Dukes, E. C., Ehrlich, R., Frank, M., Goadhouse, S., Group, R., Ho, E., Ma, H., Oksuzian, Y., Purvis, J., Wu, Y., Hertzog, D. W., Kammel, P., Lynch, K. R., and Popp, J. L.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Mu2e experiment at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the preliminary design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-2 approval., Comment: compressed file, 888 pages, 621 figures, 126 tables; full resolution available at http://mu2e.fnal.gov; corrected typo in background summary, Table 3.4

Published
2015

5. Construction techniques and performances of a full-size prototype Micromegas chamber for the ATLAS muon spectrometer upgrade

Author

Alexopoulos, T., Alviggi, M., Antonelli, M., Anulli, F., Arcangeletti, C., Bagnaia, P., Baroncelli, A., Beretta, M., Bini, C., Bortfeldt, J., Calabrò, D., Canale, V., Capocasa, F., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Ciapetti, G., D’Amico, V., De Fazio, B., Del Gaudio, M., Gkountoumis, P., Di Donato, C., Di Nardo, R., D’Uffizi, D., Farina, E., Ferrari, R., Freddi, A., Gatti, C., Gaudio, G., Gorini, E., Gravili, F., Gigli, S. Guelfo, Iakovidis, G., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Karentzos, E., Koulouris, A., Kourkoumeli-Charalampidi, A., Lacava, F., Lanza, A., La Rotonda, L., Lauciani, S., Luminari, L., Maccarrone, G., Maltezos, S., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Moschovakos, P., Ntekas, K., Palazzo, S., Paruzza, G., Petrucci, F., Pezzotti, L., Pileggi, G., Policicchio, A., Pontoriere, G., Ponzio, B., Romano, E., Romano, V., Roscilli, L., Rovelli, G., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Turco, P., Vanadia, M., Vannicola, D., Vassileva, T., Vecchio, V., Vercellati, F., and Zullo, A.

Published
2020
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6. Mu2e Conceptual Design Report

Author

Project, The Mu2e, Collaboration, Abrams, R. J., Alezander, D., Ambrosio, G., Andreev, N., Ankenbrandt, C. M., Asner, D. M., Arnold, D., Artikov, A., Barnes, E., Bartoszek, L., Bernstein, R. H., Biery, K., Biliyar, V., Bonicalzi, R., Bossert, R., Bowden, M., Brandt, J., Brown, D. N., Budagov, J., Buehler, M., Burov, A., Carcagno, R., Carey, R. M., Carosi, R., Cascella, M., Cauz, D., Cervelli, F., Chandra, A., Chang, J. K., Cheng, C., Ciambrone, P., Coleman, R. N., Cooper, M., Corcoran, M. C., Cordelli, M., Davydov, Y., de Gouvea, A. L., De Lorenzis, L., Debevec, P. T., DeJongh, F., Densham, C., Deuerling, G., Dey, J., Di Falco, S., Dixon, S., Djilkibaev, R., Drendel, B., Dukes, E. C., Dychkant, A., Echenard, B., Ehrlich, R., Evans, N., Evbota, D., Fang, I., Fast, J. E., Feher, S., Fischler, M., Frank, M., Frlez, E., Fung, S. S., Gallo, G., Galucci, G., Gaponenko, A., Genser, K., Giovannella, S., Glagolev, V., Glenzinski, D., Gnani, D., Goadhouse, S., Gollin, G. D., Grace, C., Grancagnolo, F., Group, C., Hanson, J., Hanson, S., Happacher, F., Heckmaier, E., Hedin, D., Hertzog, D. W., Hirosky, R., Hitlin, D. G., Ho, E., Huang, X., Huedem, E., Hung, P. Q., Hungerford, E. V., Ito, T., Jaskierny, W., Jedziniak, R., Johnson, R. P., Johnstone, C., Johnstone, J. A., Kahn, S. A., Kammel, P., Kang, T. I., Kashikhin, V. S., Kashikhin, V. V., Kasper, P., Kawall, D. M., Khalatian, V., Kim, M., Klebaner, A., Kocen, D., Kolomensky, Y., Kourbanis, I., Kowalkowski, J., Kozminski, J., Krempetz, K., Kumar, K. S., Kutschke, R. K., Kwarciany, R., Lackowski, T., Lamm, M., Larwill, M., Lau, K., Lee, M. J., L'Erario, A., Leveling, T., Lim, G., Lindenmeyer, C., Logashenko, V., Lontadze, T., Lopes, M., Luca, A., Lynch, K. R., Ma, T., Maffezzoli, A., Marciano, W. J., Martini, M., Masayoshi, W., Matushko, V., McAteer, M., McCrady, R., Moccoli, A., Michelotti, L., Miller, J. P., Miscetti, S., Molzon, W., Morgan, J., Mukherjee, A., Nagaitsev, S., Nagaslaev, V., Niehoff, J., Neuffer, D. V., Nicol, T., Norman, A. J., Norris, B., Odell, J., Oh, S., Oksuzian, Y., Onorato, G., Orduna, J., Orris, D., Ostojic, R., Page, T., Paschke, K. D., Pauletta, G., Peterson, T., Piacentino, G. M., Pileggi, G., Pla-Dalmau, A., Pocanic, D., Polly, C. C., Polychronakos, V., Ponzio, B., Popovic, M., Popp, J. L., Porter, F., Presbys, E., Prieto, P., Pronskikh, V., Puccinelli, F., Rabehl, R., Ramsey, J., Ray, R. E., Rechenmacher, R., Rella, S., Ristori, L., Rivera, R., Roberts, B. L., Roberts, T. J., Rubinov, P., Rusu, V. L., Saputi, A., Sarra, I., Smertzidis, Y., Shanahan, P., Simonenko, A., Steward, J., Suslov, I., Sylvester, C., Tang, Z., Tartaglia, M., Tassielli, G., Tereshchenko, V., Theilacker, J., Tompkins, J., Tschirhart, R., Van Zandbergen, G., Vannini, C., Venanzoni, G., von der Lippe, H., Wagner, R., Walder, J. P., Walton, R., Wands, S., Wang, S., Warren, G., Werkema, S., White Jr, H. B., Wielgos, R., Wood, L. S., Woodward, M., Wu, J., Xiao, M., Yamada, R., Yamin, P., Yarritu, K., Yonehara, K., Yoshikawa, C., You, Z., Yu, G., Yurkewicz, A., Zavarise, G., and Zhu, R. Y.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Physics - Accelerator Physics
Abstract

Mu2e at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the conceptual design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-1 approval, which was granted July 11, 2012., Comment: 562 pages, 339 figures

Published
2012

7. AB1316 SAFETY AND IMMUNOGENICITY OF TWO HETEROLOGOUS VACCINE SCHEDULES AGAINST SARS-CoV-2 IN PATIENTS WITH RHEUMATOID ARTHRITIS: BRAZILIAN MULTICENTER STUDY

Author

Cruz, V., primary, Lysie Libardi Lira Machado, K., additional, Gonçalves Da Silva, V., additional, Rosemarie Lallemand Tapia, K., additional, Baptista Ferreira, L., additional, Neves Burian, A. P., additional, Dias, L. H., additional, Strauss Estevez Gadelha, C., additional, Gurtler Pinheiro de Oliveira, Y., additional, Deorce de Lima, M., additional, Pizzol Pasti, L., additional, Ribeiro de Oliveira, J., additional, Fiorotti Albertino, L., additional, De Oliveira Macabú, M., additional, Zava Lorencini, P., additional, Oliveira Magalhães, V., additional, Freitas de Aguiar, M., additional, Biegelmeyer, E., additional, Dias Cardoso Ribeiro, P., additional, Matos Melo Campos Peixoto, F. M., additional, Kayser, C., additional, Wagner Silva de Souza, A., additional, Castro, C. H. D. M., additional, Ribeiro, S., additional, Holanda Da Silva Sanches, R., additional, Luiz Boechat, A., additional, Miki Pang Takatani, V., additional, Ruas Yasuda, C., additional, Queiroz Rego, D., additional, Beatriz Nazareth Alagia, R., additional, Teixeira Rebello, R., additional, Buhring, J., additional, Sartori, N., additional, Pamplona Bueno de Andrade, N., additional, Gasparini Vieira, M. L., additional, Poubel Vieira de Rezende, R., additional, Lino Baptista, K., additional, Rodrigues Campos, L., additional, Melo, A. K., additional, Santos Melo, T., additional, Rêgo, J., additional, Vieira, R. M. R., additional, Sophia Rodrigues Vieira, A., additional, Kakehasi, A., additional, Faria Moreira Gomes Tavares, A. C., additional, Teixeira de Landa, A., additional, Dias Corrêa, M. C., additional, Azevedo, V. F., additional, Assis Martins-Filho, O., additional, Peruhype-Magalhães, V., additional, Pinheiro, M., additional, Monticielo, O., additional, Torres Dos Reis Neto, E., additional, Ferreira, G., additional, De Souza, V., additional, Teixeira-Carvalho, A., additional, Xavier, R., additional, Sato, E., additional, Valim, V., additional, Salviato Pileggi, G., additional, and Da Silva, N., additional

Published
2023
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8. POS0274 PROSPECTIVE EVALUATION OF THE EFFECT OF THE VACCINE AGAINST SARS-COV-2 IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: DATA FROM SAFER STUDY

Author

Sartori, N., primary, Matos Melo Campos Peixoto, F. M., additional, Dias Cardoso Ribeiro, P., additional, Lysie Libardi Lira Machado, K., additional, Geraldo Mill, J., additional, Pretti, F. Z., additional, Gomes Gouveia, M., additional, Gurtler Pinheiro de Oliveira, Y., additional, Miyamoto, S. T., additional, Gonçalves Da Silva, V., additional, Neves Burian, A. P., additional, Rosemarie Lallemand Tapia, K., additional, Veghini, D., additional, Deorce de Lima, M., additional, Athayde, P., additional, Simões Moulin, A. C., additional, Lorenzoni Grillo, L., additional, Corona, H., additional, Fiorotti Albertino, L., additional, Pizzol Pasti, L., additional, Ramos, S., additional, Filipe Surlo, H., additional, Gonçalves Rodrigues Aguiar, L., additional, Zava Lorencini, P., additional, Pinheiro, M., additional, Oliveira Magalhães, V., additional, Freitas de Aguiar, M., additional, Biegelmeyer, E., additional, Kayser, C., additional, Wagner Silva de Souza, A., additional, Castro, C. H. D. M., additional, Gasparin, A. A., additional, Hax, V., additional, Poubel Vieira de Rezende, R., additional, Lino Baptista, K., additional, Gaudio, R. C., additional, Buhring, J., additional, Ribeiro, S., additional, Dos Santos, S. H., additional, Pinheiro Martins, C., additional, Rodrigues, J., additional, Sousa Dias, M. M., additional, Guimarães Dutra, B., additional, Telles, C., additional, Dias, S. E. B., additional, Cruz, V., additional, Rêgo, J., additional, Vieira, R. M. R., additional, Sophia Rodrigues Vieira, A., additional, Kakehasi, A., additional, Faria Moreira Gomes Tavares, A. C., additional, Dornelas, V., additional, Azevedo, R., additional, Azevedo, V. F., additional, Valim, V., additional, Teixeira-Carvalho, A., additional, Assis Martins-Filho, O., additional, Xavier, R., additional, De Souza, V., additional, Ferreira, G., additional, Salviato Pileggi, G., additional, Sato, E., additional, Torres Dos Reis Neto, E., additional, and Monticielo, O., additional

Published
2023
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9. AB1289 IS THERE HIGHER RISK OF FATIGUE, DEPRESSION, ANXIETY AND STRESS AFTER COVID-19 IN PATIENTS WITH IMMUNE-MEDIATED RHEUMATIC DISEASES? DATA FROM THE REUMACOV BRASIL COHORT

Author

Marques, C., primary, Pinheiro, M., additional, Ribeiro, S., additional, Barros DE Souza, R., additional, Valadares, L. D. D. A., additional, Ranzolin, A., additional, Cavalheiro Do Espírito Santo, R., additional, Sartori, N., additional, Araújo, N., additional, Martins Vieira, C., additional, Libardi Machado, K. L., additional, De Leon de Lima, H., additional, Sina, F., additional, Mota, L., additional, Gomides, A. P., additional, Kakehasi, A., additional, Reis Neto, E., additional, Salviato Pileggi, G., additional, Ferreira, G., additional, and Xavier, R., additional

Published
2023
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10. AB1283 COVID-19 WAS NOT TRIGGER FOR RHEUMATIC DISEASE ACTIVITY AFTER 6 MONTHS FOLLOW-UP: RESULTS FROM REUMACOV BRASIL REGISTER

Author

Marques, C., primary, Xavier, R., additional, Ribeiro, S., additional, Scrignoli, J., additional, Valadares, L. D. D. A., additional, Cavalheiro Do Espírito Santo, R., additional, Sartori, N., additional, Costa, C. Z., additional, Nacácio e Silva, P., additional, De Souza, V., additional, Machado Ribeiro, F., additional, Omura, F., additional, Resende, G., additional, Katsuyuki Shinjo, S., additional, Barbosa, V., additional, Peixoto Gu e Silva de Souza, M., additional, Carvalho, M., additional, Alexandre Yazbek, M., additional, Valim, V., additional, Rocha, L., additional, Martins, A. S., additional, Bacchiega, A. B., additional, Melo, A. K., additional, Carneiro, S., additional, Marinho, A., additional, Kakehasi, A., additional, Ferreira, G., additional, Salviato Pileggi, G., additional, Reis Neto, E., additional, Mota, L., additional, Gomides, A. P., additional, and Pinheiro, M., additional

Published
2023
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11. POS0271 HETEROLOGOUS COVID-19 BOOSTER VACCINATION PRODUCED GREATER ANTIBODY TITERS IN AUTOIMMUNE DISEASE PATIENTS: DATA FROM MULTICENTRIC PROSPECTIVE PHASE IV SAFER STUDY

Author

Lysie Libardi Lira Machado, K., primary, Miyamoto, S. T., additional, Neves Burian, A. P., additional, Dias, L. H., additional, Pretti, F. Z., additional, Cristina Filgueira Alves Batista, D., additional, Geraldo Mill, J., additional, Gurtler Pinheiro de Oliveira, Y., additional, Strauss Estevez Gadelha, C., additional, Gomes Gouveia, M., additional, Simões Moulin, A. C., additional, Gonçalves Rodrigues Aguiar, L., additional, Oliveira Souza, B., additional, Smith Sobral Vieira, G., additional, Lorenzoni Grillo, L., additional, Deorce de Lima, M., additional, Filipe Surlo, H., additional, Pizzol Pasti, L., additional, Faé, F., additional, Ribeiro Moulaz, I., additional, De Oliveira Macabú, M., additional, Dias Cardoso Ribeiro, P., additional, Oliveira Magalhães, V., additional, Freitas de Aguiar, M., additional, Biegelmeyer, E., additional, Matos Melo Campos Peixoto, F. M., additional, Kayser, C., additional, Wagner Silva de Souza, A., additional, Castro, C. H. D. M., additional, Ribeiro, S., additional, Telles, C., additional, Buhring, J., additional, Lima, R., additional, Dos Santos, S. H., additional, Dias, S. E. B., additional, Seixas de Melo, N., additional, Holanda Da Silva Sanches, R., additional, Luiz Boechat, A., additional, Sartori, N., additional, Hax, V., additional, Denardi Dória, L., additional, Poubel Vieira de Rezende, R., additional, Lino Baptista, K., additional, Rodrigues Querido Fortes, N., additional, Melo, A. K., additional, Santos Melo, T., additional, Cruz, V., additional, Rêgo, J., additional, Vieira, R. M. R., additional, Sophia Rodrigues Vieira, A., additional, Kakehasi, A., additional, Faria Moreira Gomes Tavares, A. C., additional, Teixeira de Landa, A., additional, Costa, P., additional, Azevedo, V. F., additional, Assis Martins-Filho, O., additional, Peruhype-Magalhães, V., additional, Pinheiro, M., additional, Monticielo, O., additional, Torres Dos Reis Neto, E., additional, Ferreira, G., additional, De Souza, V., additional, Teixeira-Carvalho, A., additional, Xavier, R., additional, Sato, E., additional, Salviato Pileggi, G., additional, and Valim, V., additional

Published
2023
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12. Construction and test of the SM1 type Micromegas chambers for the upgrade of the ATLAS forward muon spectrometer

Author

Agarwala J., Alviggi M. G., Antonelli M., Anulli F., Arcangeletti C., Auricchio S., Bagnaia P., Bariani S., Baroncelli A., Bashta I., Bauce M., Beretta M., Bini C., Calabro D., Camerlingo M. T., Canale V., Capitolo E., Capponi M., Capradossi G., Carducci G., Caserio A., Cassese C., Cerioni S., Chiarella V., Ciapetti G., D'Amico V., De Cecco S., De Fazio B., Del Gaudio M., Di Donato C., Di Nardo R., D'Uffizi D., Farilla A., Farina E., Ferrari R., Fiore G., Frattari G., Freddi A., Gaudio G., Gauzzi P., Giagu S., Gigli S., Gnesi I., Gorini E., Gravili F. G., Greco M., Iaciofano A., Iengo P., Innocente A., Introzzi G., Iodice M., Ippolito V., Kourkoumeli Charalampidi A., Lacava F., Lalli E., Lanza A., Lauciani S., Laurelli P., Luminari L., Mancini G., Martinelli L., Massarotti P., Miccoli A., Mirto A., Negri A., Orestano D., Paruzza G., Pepe M., Petruccetti M., Petrucci F., Pezzotti L., Pileggi G., Pirola M., Piscitelli C., Polesello G., Policicchio A., Pontoriere G., Ponzio B., Primavera M., Rebuzzi D., Rimoldi A., Romano E., Roscilli L., Rovelli G., Russo V., Sansoni A., Safai Tehrani F., Scagliotti C., Schioppa M., Sekhniaidze G., Sessa M., Sottocornola S., Trattino P., Tskhadadze E., Turco P., Vannicola D., Vannoli L., Vassilieva T., Vecchio V., Ventura A., Vercellati F., Vilucchi E., Zullo A., Zunica G., Agarwala, J., Alviggi, M. G., Antonelli, M., Anulli, F., Arcangeletti, C., Auricchio, S., Bagnaia, P., Bariani, S., Baroncelli, A., Bashta, I., Bauce, M., Beretta, M., Bini, C., Calabro, D., Camerlingo, M. T., Canale, V., Capitolo, E., Capponi, M., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Chiarella, V., Ciapetti, G., D'Amico, V., De Cecco, S., De Fazio, B., Del Gaudio, M., Di Donato, C., Di Nardo, R., D'Uffizi, D., Farilla, A., Farina, E., Ferrari, R., Fiore, G., Frattari, G., Freddi, A., Gaudio, G., Gauzzi, P., Giagu, S., Gigli, S., Gnesi, I., Gorini, E., Gravili, F. G., Greco, M., Iaciofano, A., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Ippolito, V., Kourkoumeli Charalampidi, A., Lacava, F., Lalli, E., Lanza, A., Lauciani, S., Laurelli, P., Luminari, L., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Negri, A., Orestano, D., Paruzza, G., Pepe, M., Petruccetti, M., Petrucci, F., Pezzotti, L., Pileggi, G., Pirola, M., Piscitelli, C., Polesello, G., Policicchio, A., Pontoriere, G., Ponzio, B., Primavera, M., Rebuzzi, D., Rimoldi, A., Romano, E., Roscilli, L., Rovelli, G., Russo, V., Sansoni, A., Safai Tehrani, F., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Trattino, P., Tskhadadze, E., Turco, P., Vannicola, D., Vannoli, L., Vassilieva, T., Vecchio, V., Ventura, A., Vercellati, F., Vilucchi, E., Zullo, A., and Zunica, G.

Subjects
Nuclear and High Energy Physics, Muon detector, Micromegas, Instrumentation, LHC, ATLAS, High Energy Physics, Micromegas, Muons
Abstract

Large-size Resistive Micromegas have been chosen for the upgrade of the forward muon spectrometer of the ATLAS experiment, the New Small Wheel project. These chambers, together with small-strip Thin Gap Chambers (sTGC), allow reconstruction of high-momentum muon tracks in a high-radiation environment and provide a robust low-threshold single-muon trigger. A collaboration of seven INFN units built 32 SM1 type chambers, corresponding to one fourth of the total number needed for this upgrade. Each SM1 chamber has a surface of approximately 2 m2 and four sensitive layers. The production was shared among five INFN construction sites and it was completed in fall 2020. The construction methods, as well as the results of the quality tests done on components of the detector and on the assembled chambers, are reported in the present paper.

Published
2022

14. POS1285 IMMUNOGENICITY AND SAFETY OF THE CHADOX 1 COVID-19 VACCINE IN PATIENTS WITH AUTOIMMUNE DISEASES AND HEALTHY CONTROLS: DATA FROM SAFER STUDY

Author

Lysie Libardi Lira Machado, K., primary, Martins Filho, O. A., additional, Reis Neto, E., additional, Miyamoto, S. T., additional, Ribeiro Moulaz, I., additional, Lorenzoni Grillo, L., additional, Pizzol Pasti, L., additional, Simões Moulin, A. C., additional, Oliveira Souza, B., additional, Faé, F., additional, Smith Sobral Vieira, G., additional, Filipe Surlo, H., additional, De Oliveira Macabú, M., additional, Da Silva Corona, H., additional, Zava Lorencini, P., additional, Athayde, P., additional, Gonçalves Rodrigues Aguiar, L., additional, Fiorotti Albertino, L., additional, Deorce de Lima, M., additional, Neves Burian, A. P., additional, Cruz, V., additional, Kakehasi, A., additional, Gomes, C., additional, Azevedo, V. F., additional, Melo, A. K., additional, Poubel Vieira DE Rezende, R., additional, Ribeiro, S., additional, Vieira, R. M. R., additional, Casian Tuão, R., additional, Barbosa Beloni Lirio, M., additional, De Moraes Ribeiro Espirito Santo, T., additional, Pretti, F. Z., additional, Cristina Filgueira Alves Batista, D., additional, Monticielo, O., additional, De Souza, V., additional, Pinheiro, M., additional, Ferreira, G., additional, Sato, E., additional, Teixeira-Carvalho, A., additional, Xavier, R., additional, Salviato Pileggi, G., additional, and Valim, V., additional

Published
2022
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15. AB0848 PARTICIPATION OF UNDERGRADUATE MEDICAL STUDENTS AS INVESTIGATORS IN A RHEUMATOLOGIC COHORT: IMPACT ON DEPRESSION, ANXIETY & STRESS SCALE

Author

Basualto, S., primary, Ziroldo Lopes, J. V., additional, Rizzo Borges, A., additional, Abreu, M., additional, Albuquerque, C., additional, Araújo, N., additional, Bacchiega, A. B., additional, Bica, B., additional, Brito, D., additional, Duarte, A., additional, Realle, P., additional, Ferreira, G., additional, Wagner Poti Gomes, K., additional, Melo, A. K., additional, Stadler, B., additional, Maria Kakehasi, A., additional, Klumb, E., additional, Mariz, H., additional, Marques, C., additional, Mota, L., additional, Munhoz, G., additional, Paiva, E., additional, Pereira, H., additional, Salviato Pileggi, G., additional, Pinheiro, M., additional, Provenza, J. R., additional, Gomides, A. P., additional, Reis Neto, E., additional, Ribeiro, S., additional, Sato, E., additional, Laroca Skare, T., additional, De Souza, V., additional, Teodoro, M. L. M., additional, Valadares, L. D. D. A., additional, Valim, V., additional, and Calderaro, D., additional

Published
2021
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16. POS1252 COVID-19 IN PATIENTS WITH RHEUMATIC DISEASES ON CHRONIC USE OF HYDROXYCHLOROQUINE IN A LARGE BRAZILIAN COHORT – A 24-WEEK PROSPECTIVE STUDY

Author

Salviato Pileggi, G., primary, Ferreira, G., additional, Gomides, A. P., additional, Reis Neto, E., additional, Abreu, M., additional, Albuquerque, C., additional, Araújo, N., additional, Bacchiega, A. B., additional, Bianchi, D., additional, Bica, B., additional, Bonfa, E., additional, Borba, E., additional, Brito, D., additional, Duarte, A., additional, Peixoto Gu e Silva de Souza, M., additional, Wagner Poti Gomes, K., additional, Maria Kakehasi, A., additional, Cavalheiro Do Espírito Santo, R., additional, Realle, P., additional, Klumb, E., additional, Lanna, C. C., additional, Marques, C., additional, Monticielo, O., additional, Mota, L., additional, Munhoz, G., additional, Paiva, E., additional, Pereira, H., additional, Provenza, J. R., additional, Ribeiro, S., additional, Rocha Jr, L., additional, Sampaio, C., additional, Sampaio, V., additional, Sato, E., additional, Laroca Skare, T., additional, De Souza, V., additional, Valim, V., additional, Lacerda, M., additional, Xavier, R., additional, and Pinheiro, M., additional

Published
2021
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17. Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection

Author

Uziel, Y. Moshe, V. Onozo, B. Kulcsár, A. Tróbert-Sipos, D. Akikusa, J.D. Salviato Pileggi, G. Maritsi, D. Kasapcopur, O. Rodrigues, M. Smerla, R. Rigante, D. Makay, B. Atsali, E. Wulffraat, N. Toplak, N. for the PReS working party of Vaccination Study Group

Abstract

Purpose: To collect retrospective data of patients with Juvenile Idiopathic Arthritis (JIA) and other rheumatic diseases who received live attenuated booster measles-mumps-rubella (MMR) or measles-mumps-rubella-varicella (MMR/V) during treatment with immunosuppressive therapy. Results: Data from 13 pediatric rheumatology centers in 10 countries, including 234 patients, were collected. Mean age at diagnosis was 5 ± 2.7 years, 67% were girls. Among them, 211 (90.2%) had JIA and 110 (47%) were in remission on medication. Disease activity was low in 37%, high in 8%, and moderate in 8%. One hundred-twenty-four received MMR/V booster while on methotrexate (MTX); 3 reported local mild adverse events (AE). Among 62 on MTX + biologics and 9 patients who received a combination of 2 disease modifying antirheumatic drugs (DMARDs), 9 reported mild AE. Among 39 on biologics, 1 reported fever one day after booster vaccination. No vaccine-related infection of measles, rubella, mumps or varicella was reported, none of the patients developed disease flare, including those with high disease activity. Conclusions: In this retrospective study, live-attenuated MMR/V booster vaccines were safe for children with rheumatic diseases, on immunosuppressive therapies. This strengthens the Paediatric Rheumatology European Society (PReS) recommendation that vaccination with live attenuated vaccines in patients on immunosuppressive therapies can be considered individually, weighing the benefit of vaccination against the risk of inducing infection through vaccination. These data provide the basis for a prospective data collection study, planned by the PReS vaccination study group. © 2020 Elsevier Ltd

Published
2020

18. Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection

Author

Uziel, Y, Moshe, V, Onozo, B, Kulcsár, A, Tróbert-Sipos, D, Akikusa, Jd, Salviato Pileggi, G, Maritsi, D, Kasapcopur, O, Rodrigues, M, Smerla, R, Rigante, Donato, Makay, B, Atsali, E, Wulffraat, N, Toplak, N, Rigante D (ORCID:0000-0001-7032-7779), Uziel, Y, Moshe, V, Onozo, B, Kulcsár, A, Tróbert-Sipos, D, Akikusa, Jd, Salviato Pileggi, G, Maritsi, D, Kasapcopur, O, Rodrigues, M, Smerla, R, Rigante, Donato, Makay, B, Atsali, E, Wulffraat, N, Toplak, N, and Rigante D (ORCID:0000-0001-7032-7779)

Abstract

Purpose: To collect retrospective data of patients with Juvenile Idiopathic Arthritis (JIA) and other rheumatic diseases who received live attenuated booster measles-mumps-rubella (MMR) or measles-mumps-rubellavaricella (MMR/V) during treatment with immunosuppressive therapy. Results: Data from 13 pediatric rheumatology centers in 10 countries, including 234 patients, were collected. Mean age at diagnosis was 5 ± 2.7 years, 67% were girls. Among them, 211 (90.2%) had JIA and 110 (47%) were in remission on medication. Disease activity was low in 37%, high in 8%, and moderate in 8%. One hundred-twenty-four receivedMMR/V booster while on methotrexate (MTX); 3 reported local mild adverse events (AE). Among 62 on MTX + biologics and 9 patients who received a combination of 2 disease modifying antirheumatic drugs (DMARDs), 9 reported mild AE. Among 39 on biologics, 1 reported fever one day after booster vaccination. No vaccine-related infection of measles, rubella, mumps or varicella was reported, none of the patients developed disease flare, including those with high disease activity. Conclusions: In this retrospective study, live-attenuatedMMR/V booster vaccines were safe for children with rheumatic diseases, on immunosuppressive therapies. This strengthens the Paediatric Rheumatology European Society (PReS) recommendation that vaccination with live attenuated vaccines in patients on immunosuppressive therapies can be considered individually, weighing the benefit of vaccination against the risk of inducing infection through vaccination. These data provide the basis for a prospective data collection study, planned by the PReS vaccination study group.

Published
2020

21. Live attenuated vaccines in pediatric rheumatic diseases are safe: multicenter retrospective data collection.

Author

Uziel, Y, Bergonzo, Vm, Onozo, B, Kulcsar, A, Tróbert-Sipos, D, Akikusa, J, Pileggi, G, Maritsi, D, Kasapcopur, O, Smerla, R, Rigante, Donato, Atasali, E, Rodrigues, M, Makay, B, Wulffraat, N, Toplak, N, Rigante D (ORCID:0000-0001-7032-7779), Uziel, Y, Bergonzo, Vm, Onozo, B, Kulcsar, A, Tróbert-Sipos, D, Akikusa, J, Pileggi, G, Maritsi, D, Kasapcopur, O, Smerla, R, Rigante, Donato, Atasali, E, Rodrigues, M, Makay, B, Wulffraat, N, Toplak, N, and Rigante D (ORCID:0000-0001-7032-7779)

Abstract

Common practice is to withhold vaccination with live-attenuated vaccines in patients with rheumatic diseases on high-dose DMARDs, glucocorticosteroids or biological agents, due to limited safety data, and the risk of introducing an infectious disease to the patient. Evidence for this approach is low. We collected data from pediatric rheumatologists who regularly have vaccinated these patients, to obtain additional safety data, which might update and revise such approach. Data from 13 pediatric rheumatology centers in 10 countries were collected and herein discussed.

Published
2019

22. Construction techniques and performances of a full size prototype Micromegas chamber for the ATLAS muon spectrometer upgrade

Author

Alviggi, M., Antonelli, M., Anulli, F., Arcangeletti, C., Bagnaia, P., Baroncelli, A., Beretta, M., Bini, C., Calabrò, D., Canale, V., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Ciapetti, G., D'Amico, V., De Fazio, B., Del Gaudio, M., Di Donato, C., Di Nardo, R., D'Uffizi, D., Farina, E., Ferrari, R., Freddi, A., Gatti, C., Gaudio, G., Gorini, E., Gravili, F., Guelfo Gigli, S., Innocente, A., Introzzi, G., Iodice, M., Kourkoumeli-Charalampidi, A., Lacava, F., Lanza, A., La Rotonda, L., Lauciani, S., Luminari, L., Maccarrone, G., Mancini, G., Martinelli, L., Massarotti, P., Miccoli, A., Mirto, A., Palazzo, S., Paruzza, G., Petrucci, F., Pezzotti, L., Pileggi, G., Policicchio, A., Pontoriere, G., Ponzio, B., Romano, E., Romano, V., Roscilli, L., Rovelli, G., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Turco, P., Vanadia, M., Vannicola, D., Vassileva, T., Vecchio, V., Vercellati, F., and Zullo, A.

Subjects
Micromegas chamber, INFN-18-07-LNF, ATLAS, LHC Collider
Abstract

A full scale prototype of a Micromegas precision tracking chamber for the upgrade of the ATLAS detector at the LHC Collider has been built between October 2015 and April 2016. This paper describes in detail the procedures used in constructing the single modules of the chamber in various INFN laboratories and the final assembly at the Frascati National Laboratories (LNF). Results of the chamber exposure to the CERN H8 beam line in June 2016 are also presented. The performances achieved in the construction and the results of the test beam are compared with the requirements, which are imposed by the severe environment during the data-taking of the LHC foreseen for the next years.

Published
2018
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23. Challenges in achieving consensus for vaccination with live attenuated vaccines in children with rheumatological disease – the variability of vaccination practices across the globe

Author

Toplak, Nataša, Uziel, Y, Khubchandani, R, Abinun, M, Atsali, E, Bolt, I, Boros, C, Boyko, Y, Calzada- Hernandez, J, Dallos, T, Fingerhutova, S, Gattorno, M, Hentgen, V, Lamot, Lovro, Makay, B, Minden, K, Opoka- Winiarska, V, Orban, I, Pileggi, G, Pruunsild, C, Rusoniene, S, Rygg, M, Scegolevs, A, Vojinović, J, and Wulffraat, N

Subjects
Vaccination, rheumatological diseases
Abstract

Introduction: Due to the paucity of randomised controlled studies concerning vaccination in children with rheumatic diseases, the level of evidence for recommendations for vaccinations in these children is low. Booster doses of live attenuated vaccines might be considered in children with rheumatic diseases treated with immunosuppressive therapy, but data from multicentre studies are lacking. Moreover, national vaccination programs, parental obligation to vaccinate their children and vaccine coverage rates vary greatly among countries. Objectives: To highlight differences in the current national vaccination policies, and to develop a platform for future multicentre initiatives for uniform vaccination practices for children with rheumatic diseases treated with immunosuppressive drugs. Methods: The PReS Vaccination working group was formed during the 2017 PReS meeting in Athens. Paediatric rheumatologists from 34 countries were invited to participate. Results: Data were collected from 25 countries who responded. Vaccinations are mandatory in 12/21 European countries (Croatia, Czech Republic, France, Greece, Hungary, Italy, Latvia, Poland, Serbia, Slovakia, Slovenia, Ukraine). The vaccination schedules and coverage differ among countries. The first MMR vaccine is recommended at 11-15 months- of-age in all countries and most recommend the second dose before 2 years-of-age or at 6 years ; however in Spain it is at 2-4 years, in the UK at 3-5 years, and in Hungary, The Netherlands, Estonia, Norway, Poland and Slovakia at the age of 9 years or later. Mandatory programs, as compared to optional vaccination, do not always ensure higher coverage. For example, in Australia, Israel, The Netherlands and Norway where vaccinations are optional, the vaccination rate is high, at around 95%. However, coverage for MMR fell below 95% in Croatia, Czech Republic, Serbia and Slovenia, where vaccination is mandatory. Vaccinations were optional in France and Italy ; however, due to low coverage, they are now mandatory. Conclusion: There are considerable differences amongst countries in vaccination programmes, coverage, and in parental obligation to vaccinate their child. A powerful anti-vaccine campaign has gained momentum in many countries and has resulted in a significant drop in vaccination coverage to a level that is no longer sufficient for herd immunity. This is especially dangerous for children with rheumatic diseases on immunosuppressive therapy. Our future goals are to prospectively examine the outcomes of live vaccination in children with rheumatic diseases who are treated with immunosuppressive drugs and hopefully to demonstrate that booster doses of live attenuated vaccines are safe and protective.

Published
2018

24. Mu2e Conceptual Design Report

Author

Project, The Mu2e, Collaboration, Abrams, R. J., Alezander, D., Ambrosio, G., Andreev, N., Ankenbrandt, C. M., Asner, D. M., Arnold, D., Artikov, A., Barnes, E., Bartoszek, L., Bernstein, R. H., Biery, K., Biliyar, V., Bonicalzi, R., Bossert, R., Bowden, M., Brandt, J., Brown, D. N., Budagov, J., Buehler, M., Burov, A., Carcagno, R., Carey, R. M., Carosi, R., Cascella, M., Cauz, D., Cervelli, F., Chandra, A., Chang, J. K., Cheng, C., Ciambrone, P., Coleman, R. N., Cooper, M., Corcoran, M. C., Cordelli, M., Davydov, Y., de Gouvea, A. L., De Lorenzis, L., Debevec, P. T., DeJongh, F., Densham, C., Deuerling, G., Dey, J., Di Falco, S., Dixon, S., Djilkibaev, R., Drendel, B., Dukes, E. C., Dychkant, A., Echenard, B., Ehrlich, R., Evans, N., Evbota, D., Fang, I., Fast, J. E., Feher, S., Fischler, M., Frank, M., Frlez, E., Fung, S. S., Gallo, G., Galucci, G., Gaponenko, A., Genser, K., Giovannella, S., Glagolev, V., Glenzinski, D., Gnani, D., Goadhouse, S., Gollin, G. D., Grace, C., Grancagnolo, F., Group, C., Hanson, J., Hanson, S., Happacher, F., Heckmaier, E., Hedin, D., Hertzog, D. W., Hirosky, R., Hitlin, D. G., Ho, E., Huang, X., Huedem, E., Hung, P. Q., Hungerford, E. V., Ito, T., Jaskierny, W., Jedziniak, R., Johnson, R. P., Johnstone, C., Johnstone, J. A., Kahn, S. A., Kammel, P., Kang, T. I., Kashikhin, V. S., Kashikhin, V. V., Kasper, P., Kawall, D. M., Khalatian, V., Kim, M., Klebaner, A., Kocen, D., Kolomensky, Y., Kourbanis, I., Kowalkowski, J., Kozminski, J., Krempetz, K., Kumar, K. S., Kutschke, R. K., Kwarciany, R., Lackowski, T., Lamm, M., Larwill, M., Lau, K., Lee, M. J., L'Erario, A., Leveling, T., Lim, G., Lindenmeyer, C., Logashenko, V., Lontadze, T., Lopes, M., Luca, A., Lynch, K. R., Ma, T., Maffezzoli, A., Marciano, W. J., Martini, M., Masayoshi, W., Matushko, V., McAteer, M., McCrady, R., Moccoli, A., Michelotti, L., Miller, J. P., Miscetti, S., Molzon, W., Morgan, J., Mukherjee, A., Nagaitsev, S., Nagaslaev, V., Niehoff, J., Neuffer, D. V., Nicol, T., Norman, A. J., Norris, B., Odell, J., Oh, S., Oksuzian, Y., Onorato, G., Orduna, J., Orris, D., Ostojic, R., Page, T., Paschke, K. D., Pauletta, G., Peterson, T., Piacentino, G. M., Pileggi, G., Pla-Dalmau, A., Pocanic, D., Polly, C. C., Polychronakos, V., Ponzio, B., Popovic, M., Popp, J. L., Porter, F., Presbys, E., Prieto, P., Pronskikh, V., Puccinelli, F., Rabehl, R., Ramsey, J., Ray, R. E., Rechenmacher, R., Rella, S., Ristori, L., Rivera, R., Roberts, B. L., Roberts, T. J., Rubinov, P., Rusu, V. L., Saputi, A., Sarra, I., Smertzidis, Y., Shanahan, P., Simonenko, A., Steward, J., Suslov, I., Sylvester, C., Tang, Z., Tartaglia, M., Tassielli, G., Tereshchenko, V., Theilacker, J., Tompkins, J., Tschirhart, R., Van Zandbergen, G., Vannini, C., Venanzoni, G., von der Lippe, H., Wagner, R., Walder, J. P., Walton, R., Wands, S., Wang, S., Warren, G., Werkema, S., White Jr, H. B., Wielgos, R., Wood, L. S., Woodward, M., Wu, J., Xiao, M., Yamada, R., Yamin, P., Yarritu, K., Yonehara, K., Yoshikawa, C., You, Z., Yu, G., Yurkewicz, A., Zavarise, G., and Zhu, R. Y.

Subjects
Accelerator Physics (physics.acc-ph), High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, hep-ex, FOS: Physical sciences, Physics - Accelerator Physics, Instrumentation and Detectors (physics.ins-det), physics.ins-det, High Energy Physics - Experiment, physics.acc-ph
Abstract

Mu2e at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the conceptual design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-1 approval, which was granted July 11, 2012., 562 pages, 339 figures

Published
2017

25. FRI0627 Inadvertent yellow fever vaccination of patients with immune mediated inflammatory disease in private practice.

Author

Fernandes, L., primary, Pippa, M., additional, Macedo, C., additional, Brudnewski, J., additional, Palacios, F., additional, Mahlmann, H., additional, Aliberti, L., additional, Kochen, J., additional, Aurichio, R., additional, Dourador, E., additional, Omura, F., additional, Hehn, F., additional, Baricelli, M., additional, Lerner, P., additional, Lee, S., additional, Anauate, M., additional, Azeka, E., additional, Rodrigues, L., additional, Silva, T., additional, Costa, M., additional, Hayata, A., additional, Pileggi, G., additional, and Laurindo, I., additional

Published
2018
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26. IS THERE HIGHER RISK OF FATIGUE, DEPRESSION, ANXIETY AND STRESS AFTER COVID-19 IN PATIENTS WITH IMMUNE-MEDIATED RHEUMATIC DISEASES? DATA FROM THE REUMACOV BRASIL COHORT.

Author

Marques, C., Pinheiro, M., Ribeiro, S., Barros DE Souza, R., Valadares, L. D. D. A., Ranzolin, A., Do Espírito Santo, R. Cavalheiro, Sartori, N., Araújo, N., Martins Vieira, C., Libardi Machado, K. L., De Leon de Lima, H., Sina, F., Mota, L., Gomides, A. P., Kakehasi, A., Reis Neto, E., Salviato Pileggi, G., Ferreira, G., and Xavier, R.

Published
2023
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28. HPV infection and vaccination in Systemic Lupus Erythematosus patients: What we really should know

Author

Grein, I. (Ingrid), Groot, N. (Noortje), Lacerda, M.I. (Marcela Ignacchiti), Wulffraat, N.M. (Nico), Pileggi, G. (Gecilmara), Grein, I. (Ingrid), Groot, N. (Noortje), Lacerda, M.I. (Marcela Ignacchiti), Wulffraat, N.M. (Nico), and Pileggi, G. (Gecilmara)

Abstract

Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immunogenic and safe in patients with SLE, even if antibody titres are frequently lower than those of healthy controls. Human papillomavirus (HPV) infections are more prevalent in SLE patients when compared to the healthy population. Low-risk types of this virus cause anogenital warts, while high risk types are strongly related to pre-malignant cervical abnormalities and cervical cancer. HPV vaccines have been developed to prevent these conditions. Although little is known about HPV vaccination in SLE, few studies in patients with autoimmune rheumatic diseases (AIRDs) have shown that HPV vaccines are safe, and capable to induce an immunogenic response in this group of patients. To date, available data suggest that HPV vaccines can be given safely to SLE patients. Given the increased incidence of cervical abnormalities due to HPV in SLE patients, this vaccination should be encouraged.

Published
2016
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31. Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study

Author

Ferreira, J C O A, primary, Marques, H H, additional, Ferriani, M P L, additional, Gormezano, N W S, additional, Terreri, M T, additional, Pereira, R M, additional, Magalhães, C S, additional, Campos, L M, additional, Bugni, V, additional, Okuda, E M, additional, Marini, R, additional, Pileggi, G S, additional, Barbosa, C M, additional, Bonfá, E, additional, and Silva, C A, additional

Published
2016
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32. QCALT: A tile calorimeter for KLOE-2 upgrade

Author

Balla, A., primary, Ciambrone, P., additional, Corradi, G., additional, Martini, M., additional, Paglia, C., additional, Pileggi, G., additional, Ponzio, B., additional, Saputi, A., additional, and Tagnani, D., additional

Published
2013
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34. The calorimeter project for the Mu2e experiment

Author

Budagov, J., primary, Carosi, R., additional, Cervelli, F., additional, Cheng, C., additional, Cordelli, M., additional, Davydov, Yu., additional, Downie, E.J., additional, Echenard, B., additional, Giovannella, S., additional, Glagolev, V., additional, Happacher, F., additional, Hitlin, D., additional, Lucà, A., additional, Miscetti, S., additional, Ongmonkolkul, P., additional, Onorato, G., additional, Otte, P., additional, Pezzullo, G., additional, Pileggi, G., additional, Porter, F., additional, Saputi, A., additional, Sarra, I., additional, Tassielli, G., additional, and Thomas, A., additional

Published
2013
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36. Vaccination in paediatric patients with auto-immune rheumatic diseases: A systemic literature review for the European League against Rheumatism evidence-based recommendations

Author

Heijstek, M.W., primary, Ott de Bruin, L.M., additional, Borrow, R., additional, van der Klis, F., additional, Koné-Paut, I., additional, Fasth, A., additional, Minden, K., additional, Ravelli, A., additional, Abinun, M., additional, Pileggi, G., additional, Borte, M., additional, Bijl, M., additional, and Wulffraat, N.M., additional

Published
2011
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40. Vaccination practice in children with rheumatic disease

Author

Silva, C. A. A., Terreri, M. T. R. A., Nadia Emi Aikawa, Carvalho, J. F., Pileggi, G. C. S., Ferriani, V. P. L., Barbosa, C. M. P. L., Hilário, M. O. E., Jesus, A. A., Sallum, A. M. E., Lotito, A. P. N., Liphaus, B. L., Magalhães, C. S., Len, C. A., Okuda, E. M., Campos, L. M. M., Carvalho, L. M., Ronchezel, M. V., Dos Santos, M. C., Romanelli, P. R. S., Marini, R., Pereira, R. M. R., Sacchetti, S. B., Lotufo, S., and Bastos, W. A.

Subjects
Rheumatology, Rheumatic Diseases, Vaccination, Humans, Practice Patterns, Physicians', Child, Pediatrics
Abstract

Evaluate clinical practice through assessment of vaccination card and recommendation of specific vaccines in pediatric patients with rheumatic diseases in use of different drugs and reveal the possible association between vaccination frequency and time of the clinical practice of pediatric rheumatologists in the state of São Paulo.A questionnaire was sent to pediatric rheumatologists of the Departamento de Reumatologia da Sociedade de Pediatria de São Paulo. This instrument included questions about practice time on Pediatric Rheumatology, vaccination of patients with juvenile systemic lupus erythematosus (JSLE), juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM), and immunization according to the treatments used.Vaccination card was seen by 100% of the professionals at the first visit and by 36% annually. Vaccines of live agents were not recommended for patients with JSLE, JIA, and JDM in 44%, 64%, and 48%, respectively. The professionals were divided into two groups: Group A (≤ 15 years of practice, n = 12) and B (≥ 16 years, n = 13). No statistical difference was observed in the use of live agent vaccine and vaccines with inactivated agents or protein components in the two treatment groups (P0.05). Moreover, the groups had similar opinion regarding severity of immunosuppression in patients with JSLE, JIA, and JDM (with or without activity) and treatment used (P0.05).The frequency of immunization by pediatric rheumatologists in São Paulo is low, especially after the first visit, and not influenced by time of professional practice.

42. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Zara Izadi, Milena A Gianfrancesco, Gabriela Schmajuk, Lindsay Jacobsohn, Patricia Katz, Stephanie Rush, Clairissa Ja, Tiffany Taylor, Kie Shidara, Maria I Danila, Katherine D Wysham, Anja Strangfeld, Elsa F Mateus, Kimme L Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Samar Al-Emadi, Jeffrey A Sparks, Tiffany Y-T Hsu, Naomi J Patel, Leanna Wise, Emily Gilbert, Alí Duarte-García, Maria O Valenzuela-Almada, Manuel F Ugarte-Gil, Lotta Ljung, Carlo A Scirè, Greta Carrara, Eric Hachulla, Christophe Richez, Patrice Cacoub, Thierry Thomas, Maria J Santos, Miguel Bernardes, Rebecca Hasseli, Anne Regierer, Hendrik Schulze-Koops, Ulf Müller-Ladner, Guillermo Pons-Estel, Romina Tanten, Romina E Nieto, Cecilia N Pisoni, Yohana S Tissera, Ricardo Xavier, Claudia D Lopes Marques, Gecilmara C S Pileggi, Philip C Robinson, Pedro M Machado, Emily Sirotich, Jean W Liew, Jonathan S Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Monique Gore-Massy, Zachary S Wallace, Jinoos Yazdany, Brahim Dahou, Gimena Gómez, Karen Roberts, Roberto M Baez, Vanessa V Castro Coello, María J Haye Salinas, Federico N Maldonado, Alvaro A Reyes, Gelsomina Alle, Hernán Maldonado Ficco, Romina Nieto, Carla Gobbi, Yohana Tissera, Cecilia Pisoni, Alba Paula, Juan A Albiero, Maria M Schmid, Micaela Cosatti, Maria J Gamba, Carlevaris Leandro, María A Cusa, Noelia German, Veronica Bellomio, Lorena Takashima, Mariana Pera, Karina Cogo, Maria S Gálvez Elkin, María A Medina, Veronica Savio, Romina Rojas Tessel, Rodolfo P Alamino, Marina L Werner, Sofía Ornella, Luciana Casalla, Maria de la Vega, María Severina, Mercedes García, Luciana Gonzalez Lucero, Cecilia Romeo, Sebastián Moyano, Tatiana Barbich, Ana Bertoli, Andrea Baños, Sandra Petruzzelli, Carla Matellan, Silvana Conti, Maria A Lazaro, Gustavo F Rodriguez Gil, Fabian Risueño, Maria I Quaglia, Julia Scafati, Natalia L Cuchiaro, Jonathan E Rebak, Susana I Pineda, María E Calvo, Eugenia Picco, Josefina G Yanzi, Pablo Maid, Debora Guaglianone, Julieta S Morbiducci, Sabrina Porta, Natalia Herscovich, José L Velasco Zamora, Boris Kisluk, Maria S Castaños Menescardi, Rosana Gallo, María V Martire, Carla Maldini, Cecilia Goizueta, Sabrina S de la Vega Fernandez, Carolina Aeschlimann, Gisela Subils, Eva Rath, Yves Piette, Mieke Devinck, Bea Maeyaert, Francinne Machado Ribeiro, Sandra L Euzebio Ribeiro, Marcelo Pinheiro, Sebastián Ibáñez, Anne-Marie Chassin Trubert, Lingli Dong, Lui Cajas, Marko Barešić, Branimir Anić, Melanie-Ivana Ćulo, Tea A Pavelić, Kristina K Stranski, Boris Karanovic, Jiri Vencovsky, Marta Píchová, Maria Filkova, Hesham Hamoud, Dimitrios Vassilopoulos, Gabriela M Guzman Melgar, Ho So, Márta Király, Mahdi Vojdanian, Alexandra Balbir Gurman, Fatemah Abutiban, Julija Zepa, Inita Bulina, Loreta Bukauskiene, Beatriz E Zazueta Montiel, Angel A Castillo Ortiz, Erick Zamora Tehozol, David Vega Morales, Diana Cervántes Rosete, Eduardo Martín Nares, Tatiana S Rodriguez Reyna, Marina Rull Gabayet, Deshiré Alpízar Rodríguez, Fedra Irazoque, Xochitl Jimenez, Lenny Geurts van Bon, Theo Zijlstra, Monique Hoekstra, Nasra Al Adhoubi, Babur Salim, Enrique Giraldo, Ariel Salinas, Manuel Ugarte Gil, Jarosław Nowakowski, Richard Conway, Rachael Flood, Geraldine McCarthy, Ioana Felea, Ileana Filipescu, Simona Rednic, Laura Groseanu, Maria M Tamas, Vanda Mlynarikova, Martina Skamlova, Martin Zlnay, Dagmar Mičeková, Lubica Capova, Zelmira Macejova, Emőke Šteňová, Helena Raffayova, Gabriela Belakova, Eva Strakova, Marieta Senčarová, Soňa Žlnayová, Anna Sabová, Daniela Spisakova, Mária Oetterová, Olga Lukacova, Martina Bakosova, Alojzija Hocevar, Natalia de la Torre Rubio, Juan J Alegre Sancho, Montserrat Corteguera Coro, Juan C Cobeta Garcia, Maria C Torres Martin, Jose Campos, Jose A Gomez Puerta, Gozd K Yardimci, Servet Akar, Ozan C Icacan, Selda ÇELİK, Viktoriia Vasylets, Su-Ann Yeoh, Claire Vandevelde, Sasha Dunt, Jane Leeder, Elizabeth Macphie, Rosaria Salerno, Christine Graver, Katie Williams, Sheila O'Reilly, Kirsty Devine, Jennifer Tyler, Elizabeth Warner, James Pilcher, Samir Patel, Elena Nikiphorou, Laura Chadwick, Caroline M Jones, Beverley Harrison, Lucy Thornton, Diana O'Kane, Lucia Fusi, Audrey Low, Sarah Horton, Shraddha Jatwani, Sara Baig, Hammad Bajwa, Vernon Berglund, Angela Dahle, Walter Dorman, Jody Hargrove, Maren Hilton, Nicholas Lebedoff, Susan Leonard, Jennifer Morgan, Emily Pfeifer, Archibald Skemp, Jeffrey Wilson, Anne Wolff, Eduardo Cepeda, Derrick Todd, Denise Hare, Cassandra Calabrese, Christopher Adams, Arezou Khosroshahi, Adam Kilian, Douglas White, Melanie Winter, Theodore Fields, Caroline Siegel, Nicole Daver, Melissa Harvey, Neil Kramer, Concetta Lamore, Suneya Hogarty, Karen Yeter, Faizah Siddique, Byung Ban, Tamar Tanner, Eric Ruderman, William Davis, Robert Quinet, Evangeline Scopelitis, Karen Toribio, Tameka Webb Detiege, Jerald Zakem, Khurram Abbass, Gilbert Kepecs, Lilliam Miranda, Michael Guma, Ammar Haikal, Sushama Mody, Daric Mueller, Arundathi Jayatilleke, JoAnn Zell, Alison Bays, Kathryn Dao, Fatemeh Ezzati, Deborah Parks, David Karp, Guillermo Quiceno, Izadi, Z, Gianfrancesco, M, Schmajuk, G, Jacobsohn, L, Katz, P, Rush, S, Ja, C, Taylor, T, Shidara, K, Danila, M, Wysham, K, Strangfeld, A, Mateus, E, Hyrich, K, Gossec, L, Carmona, L, Lawson-Tovey, S, Kearsley-Fleet, L, Schaefer, M, Al-Emadi, S, Sparks, J, Hsu, T, Patel, N, Wise, L, Gilbert, E, Duarte-Garcia, A, Valenzuela-Almada, M, Ugarte-Gil, M, Ljung, L, Scire, C, Carrara, G, Hachulla, E, Richez, C, Cacoub, P, Thomas, T, Santos, M, Bernardes, M, Hasseli, R, Regierer, A, Schulze-Koops, H, Muller-Ladner, U, Pons-Estel, G, Tanten, R, Nieto, R, Pisoni, C, Tissera, Y, Xavier, R, Lopes Marques, C, Pileggi, G, Robinson, P, Machado, P, Sirotich, E, Liew, J, Hausmann, J, Sufka, P, Grainger, R, Bhana, S, Gore-Massy, M, Wallace, Z, Yazdany, J, Dahou, B, Gomez, G, Roberts, K, Baez, R, Castro Coello, V, Haye Salinas, M, Maldonado, F, Reyes, A, Alle, G, Maldonado Ficco, H, Gobbi, C, Paula, A, Albiero, J, Schmid, M, Cosatti, M, Gamba, M, Leandro, C, Cusa, M, German, N, Bellomio, V, Takashima, L, Pera, M, Cogo, K, Galvez Elkin, M, Medina, M, Savio, V, Rojas Tessel, R, Alamino, R, Werner, M, Ornella, S, Casalla, L, de la Vega, M, Severina, M, Garcia, M, Gonzalez Lucero, L, Romeo, C, Moyano, S, Barbich, T, Bertoli, A, Banos, A, Petruzzelli, S, Matellan, C, Conti, S, Lazaro, M, Rodriguez Gil, G, Risueno, F, Quaglia, M, Scafati, J, Cuchiaro, N, Rebak, J, Pineda, S, Calvo, M, Picco, E, Yanzi, J, Maid, P, Guaglianone, D, Morbiducci, J, Porta, S, Herscovich, N, Velasco Zamora, J, Kisluk, B, Castanos Menescardi, M, Gallo, R, Martire, M, Maldini, C, Goizueta, C, de la Vega Fernandez, S, Aeschlimann, C, Subils, G, Rath, E, Piette, Y, Devinck, M, Maeyaert, B, Machado Ribeiro, F, Euzebio Ribeiro, S, Pinheiro, M, Ibanez, S, Chassin Trubert, A, Dong, L, Cajas, L, Baresic, M, Anic, B, Culo, M, Pavelic, T, Stranski, K, Karanovic, B, Vencovsky, J, Pichova, M, Filkova, M, Hamoud, H, Vassilopoulos, D, Guzman Melgar, G, So, H, Kiraly, M, Vojdanian, M, Balbir Gurman, A, Abutiban, F, Zepa, J, Bulina, I, Bukauskiene, L, Zazueta Montiel, B, Castillo Ortiz, A, Zamora Tehozol, E, Vega Morales, D, Cervantes Rosete, D, Martin Nares, E, Rodriguez Reyna, T, Rull Gabayet, M, Alpizar Rodriguez, D, Irazoque, F, Jimenez, X, Geurts van Bon, L, Zijlstra, T, Hoekstra, M, Al Adhoubi, N, Salim, B, Giraldo, E, Salinas, A, Ugarte Gil, M, Nowakowski, J, Conway, R, Flood, R, Mccarthy, G, Felea, I, Filipescu, I, Rednic, S, Groseanu, L, Tamas, M, Mlynarikova, V, Skamlova, M, Zlnay, M, Micekova, D, Capova, L, Macejova, Z, Stenova, E, Raffayova, H, Belakova, G, Strakova, E, Sencarova, M, Zlnayova, S, Sabova, A, Spisakova, D, Oetterova, M, Lukacova, O, Bakosova, M, Hocevar, A, de la Torre Rubio, N, Alegre Sancho, J, Corteguera Coro, M, Cobeta Garcia, J, Torres Martin, M, Campos, J, Gomez Puerta, J, Yardimci, G, Akar, S, Icacan, O, Celik, S, Vasylets, V, Yeoh, S, Vandevelde, C, Dunt, S, Leeder, J, Macphie, E, Salerno, R, Graver, C, Williams, K, O'Reilly, S, Devine, K, Tyler, J, Warner, E, Pilcher, J, Patel, S, Nikiphorou, E, Chadwick, L, Jones, C, Harrison, B, Thornton, L, O'Kane, D, Fusi, L, Low, A, Horton, S, Jatwani, S, Baig, S, Bajwa, H, Berglund, V, Dahle, A, Dorman, W, Hargrove, J, Hilton, M, Lebedoff, N, Leonard, S, Morgan, J, Pfeifer, E, Skemp, A, Wilson, J, Wolff, A, Cepeda, E, Todd, D, Hare, D, Calabrese, C, Adams, C, Khosroshahi, A, Kilian, A, White, D, Winter, M, Fields, T, Siegel, C, Daver, N, Harvey, M, Kramer, N, Lamore, C, Hogarty, S, Yeter, K, Siddique, F, Ban, B, Tanner, T, Ruderman, E, Davis, W, Quinet, R, Scopelitis, E, Toribio, K, Webb Detiege, T, Zakem, J, Abbass, K, Kepecs, G, Miranda, L, Guma, M, Haikal, A, Mody, S, Mueller, D, Jayatilleke, A, Zell, J, Bays, A, Dao, K, Ezzati, F, Parks, D, Karp, D, Quiceno, G, and Repositório da Universidade de Lisboa

Subjects
health care disparity, Immunology, air pollution, cohort analysi, mortality rate, Autoimmune Disease, Article, coronavirus disease 2019, biocontainment, Rheumatology, male, cardiovascular disease, environmental factor, death, geographic distribution, Immunology and Allergy, follow up, controlled study, human, population density, outcome assessment, rheumatic disease, diabetes mellitu, adult, Prevention, market, temperature, mortality, United Kingdom, Europe, aged, female, workplace, Good Health and Well Being, human development, particulate matter 2.5, statistical analysi, North America, incidence, life expectancy, social aspect, COVID-19 Global Rheumatology Alliance Registry, observational study, demographic
Abstract

Published by Elsevier Ltd., Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death. Findings: 14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01-1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10-1·30]; p, MAG is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant numbers K01 AR070585 and K24 AR074534 [JY]). KDW is supported by the Department of Veterans Affairs and the Rheumatology Research Foundation Scientist Development award. JAS is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant numbers K23 AR069688, R03 AR075886, L30 AR066953, P30 AR070253, and P30 AR072577), the Rheumatology Research Foundation (K Supplement Award and R Bridge Award), the Brigham Research Institute, and the R. Bruce and Joan M. Mickey Research Scholar Fund. NJP is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32-AR-007258). AD-G is supported by grants from the Centers for Disease Control and Prevention and the Rheumatology Research Foundation. RH was supported by the Justus-Liebig University Giessen Clinician Scientist Program in Biomedical Research to work on this registry. JY is supported by grants from the National Institutes of Health (K24 AR074534 and P30 AR070155).

Published
2022

43. Proton range shift analysis on brain pseudo-CT generated from T1 and T2 MR

Author

David Izquierdo Garcia, Ciprian Catana, Francesco Amato, Christoph Speier, Jennifer Pursley, Joao Seco, Maria Francesca Spadea, Giampaolo Pileggi, Gregory C. Sharp, Pileggi, G., Speier, C., Sharp, G. C., Izquierdo Garcia, D., Catana, C., Pursley, J., Amato, F., Seco, J., and Spadea, M. F.

Subjects
Electron density, Proton, Dose calculation, medicine.medical_treatment, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, Image Processing, Computer-Assisted, Proton Therapy, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Range (particle radiation), Brain Neoplasms, business.industry, Radiotherapy Planning, Computer-Assisted, Skull, Reproducibility of Results, Hematology, General Medicine, Magnetic Resonance Imaging, Mr imaging, Radiation therapy, Soft tissue contrast, Oncology, 030220 oncology & carcinogenesis, Protons, Glioblastoma, Tomography, X-Ray Computed, business, Algorithms
Abstract

In radiotherapy, MR imaging is only used because it has significantly better soft tissue contrast than CT, but it lacks electron density information needed for dose calculation. This work assesses the feasibility of using pseudo-CT (pCT) generated from T1w/T2w MR for proton treatment planning, where proton range comparisons are performed between standard CT and pCT.MR and CT data from 14 glioblastoma patients were used in this study. The pCT was generated by using conversion libraries obtained from tissue segmentation and anatomical regioning of the T1w/T2w MR. For each patient, a plan consisting of three 18 Gy beams was designed on the pCT, for a total of 42 analyzed beams. The plan was then transferred onto the CT that represented the ground truth. Range shift (RS) between pCT and CT was computed at RMean absolute error and bias for the pCT were 124 ± 10 and -16 ± 26 Hounsfield Units (HU), respectively. The median and interquartile range of RS was 0.5 and 1.4 mm, with highest absolute value being 4.4 mm. Of the 42 beams, 40 showed RS less than the clinical range margin. The two beams with larger RS were both in the cranio-caudal direction and had segmentation errors due to the partial volume effect, leading to misassignment of the HU.This study showed the feasibility of using T1w and T2w MRI to generate a pCT for proton therapy treatment, thus avoiding the use of a planning CT and allowing better target definition and possibilities for online adaptive therapies. Further improvements of the methodology are still required to improve the conversion from MRI intensities to HUs.

Published
2018

44. Construction techniques and performances of a full-size prototype Micromegas chamber for the ATLAS muon spectrometer upgrade

Author

Givi Sekhniaidze, A. Caserio, G. Pontoriere, L. Roscilli, Athina Kourkoumeli-Charalampidi, Antonio Policicchio, D. D’Uffizi, Marco Vanadia, R. Di Nardo, V. Romano, M. Beretta, Stavros Maltezos, A. Freddi, Fabrizio Petrucci, Edoardo Maria Farina, Valentina Vecchio, D. Calabrò, G. Capradossi, Mauro Iodice, E. Karentzos, S. Lauciani, B. De Fazio, B. Ponzio, Lamberto Luminari, E. Romano, Mariagrazia Alviggi, Lorenzo Pezzotti, Francesco Lacava, Francesco Giuseppe Gravili, M. Del Gaudio, Claudio Gatti, Paolo Bagnaia, Luca Martinelli, Roberto Ferrari, A. Mirto, T. Vassileva, G. Gaudio, Chiara Arcangeletti, Georgios Iakovidis, K. Ntekas, Paolo Massarotti, Valerio D'Amico, C. Scagliotti, Giovanni Maccarrone, P. Turco, F. Anulli, Giovandomenico Carducci, Giulia Rovelli, A. Lanza, A. Zullo, Serena Palazzo, A. Koulouris, Cesare Bini, A. Miccoli, Marco Sessa, G. Ciapetti, Giada Mancini, Francesca Capocasa, P. Moschovakos, Edoardo Gorini, G. Pileggi, Massimo Antonelli, L. La Rotonda, A. Innocente, F. Vercellati, Antonio Baroncelli, S. Guelfo Gigli, J. Bortfeldt, Paolo Iengo, Vincenzo Canale, Simone Sottocornola, C. Cassese, Marco Schioppa, G. Paruzza, Gianluca Introzzi, P. Gkountoumis, Theodoros Alexopoulos, S. Cerioni, C. Di Donato, Damiano Vannicola, Alviggi, M., Canale, V., Massarotti, P., Alexopoulos, T., Antonelli, M., Anulli, F., Arcangeletti, C., Bagnaia, P., Baroncelli, A., Beretta, M., Bini, C., Bortfeldt, J., Calabro, D., Capocasa, F., Capradossi, G., Carducci, G., Caserio, A., Cassese, C., Cerioni, S., Ciapetti, G., D'Amico, V., De Fazio, B., Del Gaudio, M., Gkountoumis, P., Di Donato, C., Di Nardo, R., D'Uffizi, D., Farina, E., Ferrari, R., Freddi, A., Gatti, C., Gaudio, G., Gorini, E., Gravili, F., Gigli, S. G., Iakovidis, G., Iengo, P., Innocente, A., Introzzi, G., Iodice, M., Karentzos, E., Koulouris, A., Kourkoumeli-Charalampidi, A., Lacava, F., Lanza, A., La Rotonda, L., Lauciani, S., Luminari, L., Maccarrone, G., Maltezos, S., Mancini, G., Martinelli, L., Miccoli, A., Mirto, A., Moschovakos, P., Ntekas, K., Palazzo, S., Paruzza, G., Petrucci, F., Pezzotti, L., Pileggi, G., Policicchio, A., Pontoriere, G., Ponzio, B., Romano, E., Romano, V., Roscilli, L., Rovelli, G., Scagliotti, C., Schioppa, M., Sekhniaidze, G., Sessa, M., Sottocornola, S., Turco, P., Vanadia, M., Vannicola, D., Vassileva, T., Vecchio, V., Vercellati, F., and Zullo, A.

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Nuclear engineering, Atlas muon spectrometer, FOS: Physical sciences, Physics Instrumentation and Detectors, High Energy Physics Experiment, Micromegas, Muon detector, Tracking (particle physics), 01 natural sciences, law.invention, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), law, 0103 physical sciences, Detectors and Experimental Techniques, 010306 general physics, Collider, Particle beam, Nuclear Experiment, Instrumentation, physics.ins-det, Physics, Large Hadron Collider, 010308 nuclear & particles physics, hep-ex, Micromega, MicroMegas detector, Instrumentation and Detectors (physics.ins-det), Upgrade, Test beam, Physics::Accelerator Physics, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

A full-size prototype of a Micromegas precision tracking chamber for the upgrade of the ATLAS detector at the LHC Collider has been built between October 2015 and April 2016. This paper describes in detail the procedures used in constructing the single modules of the chamber in various INFN laboratories and the final assembly at the Laboratori Nazionali di Frascati (LNF). Results of the chamber exposure to the CERN SPS/H8 beam line in June 2016 are also presented. The performances achieved in the construction and the results of the test beam are compared with the requirements, which are imposed by the severe environment during the data-taking of the LHC foreseen for the next years., Contact editors: G. Mancini, A. Kourkoumeli-Charalampidi

Published
2019

45. Deep Convolution Neural Network (DCNN) Multiplane Approach to Synthetic CT Generation From MR images-Application in Brain Proton Therapy

Author

David Izquierdo-Garcia, Patrick Salome, Francesco Amato, Maria Francesca Spadea, Joao Seco, Ciprian Catana, Giampaolo Pileggi, Paolo Zaffino, Spadea, M. F., Pileggi, G., Zaffino, P., Salome, P., Catana, C., Izquierdo-Garcia, D., Amato, F., and Seco, J.

Subjects
Cancer Research, Mean squared error, computer.software_genre, Multimodal Imaging, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Voxel, Hounsfield scale, medicine, Proton Therapy, Humans, Radiology, Nuclear Medicine and imaging, Proton therapy, Technology, Radiologic, Radiation, medicine.diagnostic_test, business.industry, Brain Neoplasms, Air, Radiotherapy Planning, Computer-Assisted, Skull, Reproducibility of Results, Magnetic resonance imaging, Radiotherapy Dosage, Magnetic Resonance Imaging, Sagittal plane, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Coronal plane, Feasibility Studies, Tomography, Neural Networks, Computer, Nuclear medicine, business, Glioblastoma, Tomography, X-Ray Computed, computer, Head, Algorithms, Radiotherapy, Image-Guided
Abstract

The first aim of this work is to present a novel deep convolution neural network (DCNN) multiplane approach and compare it to single-plane prediction of synthetic computed tomography (sCT) by using the real computed tomography (CT) as ground truth. The second aim is to demonstrate the feasibility of magnetic resonance imaging (MRI)-based proton therapy planning for the brain by assessing the range shift error within the clinical acceptance threshold.The image database included 15 pairs of MRI/CT scans of the head. Three DCNNs were trained to estimate, for each voxel, the Hounsfield unit (HU) value from MRI intensities. Each DCNN gave an estimation in the axial, sagittal, and coronal plane, respectively. The median HU among the 3 values was selected to build the sCT. The sCT/CT agreement was evaluated by a mean absolute error (MAE) and mean error, computed within the head contour and on 6 different tissues. Dice similarity coefficients were calculated to assess the geometric overlap of bone and air cavities segmentations. A 3-beam proton therapy plan was simulated for each patient. Beam-by-beam range shift (RS) analysis was conducted to assess the proton-stopping power estimation. RS analysis was performed using clinically accepted thresholds of (1) 3.5% + 1 mm and (2) 2.5% + 1.5 mm of the total range.DCNN multiplane statistically outperformed single-plane prediction of sCT (P.025). MAE and mean error within the head were 54 ± 7 HU and -4 ± 17 HU (mean ± standard deviation), respectively. Soft tissues were very close to perfect agreement (11 ± 3 HU in terms of MAE). Segmentation of air and bone regions led to a Dice similarity coefficient of 0.92 ± 0.03 and 0.93 ± 0.02, respectively. Proton RS was always below clinical acceptance thresholds, with a relative RS error of 0.14% ± 1.11%.The multiplane DCNN approach significantly improved the sCT prediction compared with other DCNN methods presented in the literature. The method was demonstrated to be highly accurate for MRI-only proton planning purposes.

Published
2018

46. The calorimeter project for the Mu2e experiment

Author

G. Onorato, M. Cordelli, G. F. Tassielli, Gianantonio Pezzullo, S. Miscetti, F. Cervelli, I. Sarra, E. J. Downie, F. Happacher, P Ongmonkolkul, C. H. Cheng, G. Pileggi, B. Echenard, Y. Davydov, S. Giovannella, Anthony W. Thomas, P. Otte, J. Budagov, A. Saputi, D. G. Hitlin, A. Luca, R. Carosi, V. Glagolev, F. C. Porter, Budagov, J., Carosi, R., Cervelli, F., Cheng, C., Cordelli, M., Davydov, Yu., Downie, E. J., Echenard, B., Giovannella, S., Glagolev, V., Happacher, F., Hitlin, D., Lucà, A., Miscetti, S., Ongmonkolkul, P., Onorato, G., Otte, P., Pezzullo, G., Pileggi, G., Porter, F., Saputi, A., Sarra, I., Tassielli, G., and Thomas, A.

Subjects
Physics, Lyso crystal, Nuclear and High Energy Physics, Particle physics, Photon, Muon, Calorimeter (particle physics), Mu2e experiment, Physics::Instrumentation and Detectors, Electron, Calorimetry, Nuclear physics, Mu2e, High Energy Physics::Experiment, Invariant mass, Fermilab, Instrumentation, Lepton, Nuclear and High Energy Physic
Abstract

The Mu2e experiment at Fermilab aims to measure the charged lepton flavor violating neutrinoless conversion of a negative muon into an electron. The conversion results in a monochromatic electron with an energy slightly below the rest mass of the muon (104.97 MeV). We expect to set a limit of ∼ 6×10^(−17) at 90% CL in three years of running, using an intense and clean pulsed μ^− beam providing ∼10^(18) stopped muons on target in three years of running. The experiment performs a strong suppression of potential background by gating off the prompts and performing precise momentum determination in conjunction with an highly efficient cosmic veto. The calorimeter should confirm that the candidates reconstructed by the tracker system are indeed conversion electrons and provide an independent trigger (or event reduction filter) for the experiment. It should also provide standalone muon to electron rejection. Moreover, it must be able to keep functionality in a high radiation dose environment inside a 10^(−4)_(torr) vacuum enclosure and in a presence of 1 T axial magnetic field. In order to accomplish all these tasks, a LYSO crystals calorimeter has been chosen. We show the proposed design and the experimental results obtained by exposing a small size calorimeter prototype to a tagged photon beam from 40 to 300 MeV at the A2 photon facility of the Mainz Microton (MAMI), Germany.

Published
2013

47. How Did Patients Living With Immune-Mediated Rheumatic Diseases Face the Beginning of the COVID-19 Pandemic in Brazil? Results of the COnVIDa Study.

Author

Pugliesi A, Sachetto Z, de Medeiros Pinheiro M, Salviato Pileggi G, Sarot Pereira da Cunha G, Hajar FN, Marques Negrisolli Cunha ML, Henrique da Mota LM, Lopes Marques CD, Kakehasi AM, Rodrigues Ferreira WH, Araújo NC, Monteiro Gomides Reis AP, Rodrigues de Abreu Vieira RM, Ferreira GA, Danowski A, de Souza VA, Soares Egypto de Brito DC, Dos Santos Paiva E, Provenza JR, and Feijó Azevedo V

Subjects
Humans, Female, Adult, Middle Aged, Brazil epidemiology, Pandemics, Cross-Sectional Studies, COVID-19, Rheumatic Diseases epidemiology
Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has brought additional burden to patients living with immune-mediated rheumatic diseases (IMRDs), especially at the beginning of 2020, for which information for this population is lacking., Methods: COnVIDa is a cross-sectional study on patients with IMRD from all regions of Brazil who were invited to answer a specific and customized Web questionnaire about how they were facing the COVID-19 pandemic, especially focusing on health care access, use of medications, and patient-reported outcomes related to IMRD activity. The questionnaire was applied from June 1 to 30, 2020., Results: In total, 1722 of 2576 patients who answered the Web questionnaire were included in the final analysis. Participants were most frequently women, 56% were between 31 and 50 years old, and most (55%) has private health insurance. The most commonly reported IMRD was rheumatoid arthritis (39%), followed by systemic lupus erythematosus (28%). During the study period, 30.7% did not have access to rheumatology consultations, and 17.6% stopped chronic medications. Telemedicine was reported in 44.8% of patients., Conclusion: COnVIDa demonstrated a negative impact on health care access and treatment maintenance of patients living with IMRD during the COVID-19 pandemic. However, it also presented an uptake of telemedicine strategies. Data presented in this study may assist future coping policies., Competing Interests: The authors declare no conflict of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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49. Microbiome-based disease prediction with multimodal variational information bottlenecks.

Author

Grazioli F, Siarheyeu R, Alqassem I, Henschel A, Pileggi G, and Meiser A

Subjects
Humans, Machine Learning, Metagenome, Metagenomics methods, Gastrointestinal Microbiome, Microbiota genetics
Abstract

Scientific research is shedding light on the interaction of the gut microbiome with the human host and on its role in human health. Existing machine learning methods have shown great potential in discriminating healthy from diseased microbiome states. Most of them leverage shotgun metagenomic sequencing to extract gut microbial species-relative abundances or strain-level markers. Each of these gut microbial profiling modalities showed diagnostic potential when tested separately; however, no existing approach combines them in a single predictive framework. Here, we propose the Multimodal Variational Information Bottleneck (MVIB), a novel deep learning model capable of learning a joint representation of multiple heterogeneous data modalities. MVIB achieves competitive classification performance while being faster than existing methods. Additionally, MVIB offers interpretable results. Our model adopts an information theoretic interpretation of deep neural networks and computes a joint stochastic encoding of different input data modalities. We use MVIB to predict whether human hosts are affected by a certain disease by jointly analysing gut microbial species-relative abundances and strain-level markers. MVIB is evaluated on human gut metagenomic samples from 11 publicly available disease cohorts covering 6 different diseases. We achieve high performance (0.80 < ROC AUC < 0.95) on 5 cohorts and at least medium performance on the remaining ones. We adopt a saliency technique to interpret the output of MVIB and identify the most relevant microbial species and strain-level markers to the model's predictions. We also perform cross-study generalisation experiments, where we train and test MVIB on different cohorts of the same disease, and overall we achieve comparable results to the baseline approach, i.e. the Random Forest. Further, we evaluate our model by adding metabolomic data derived from mass spectrometry as a third input modality. Our method is scalable with respect to input data modalities and has an average training time of < 1.4 seconds. The source code and the datasets used in this work are publicly available., Competing Interests: The authors have declared that no competing interests exist.

Published
2022
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50. Impact of Chronic Use of Antimalarials on SARS-CoV-2 Infection in Patients With Immune-Mediated Rheumatic Diseases: Protocol for a Multicentric Observational Cohort Study.

Author

Gomides A, Ferreira G, Kakehasi A, Lacerda M, Marques C, Mota L, Paiva E, Pileggi G, Provenza J, Reis-Neto E, Sampaio V, Xavier R, and Pinheiro M

Abstract

Background: COVID-19, caused by the virus SARS-CoV-2, has brought extensive challenges to the scientific community in recent months. Several studies have been undertaken in an attempt to minimize the impact of the disease worldwide. Although new knowledge has been quickly disseminated, including viral mechanisms, pathophysiology, and clinical findings, there is a lack of information on the effective pharmacological management of this disease. In vitro studies have shown some benefits related to the use of antimalarials (chloroquine and hydroxychloroquine) for inhibiting SARS-CoV-2. However, the data from open clinical trials on COVID-19 patients are controversial., Objective: We present the protocol for a research project that compares the potential protective effect of antimalarials in preventing moderate-to-severe forms of COVID-19 in two groups: (1) patients treated chronically with antimalarials for rheumatic diseases and (2) other members of the patients' household who have not been diagnosed with rheumatic diseases and are not taking antimalarials., Methods: This is a 24-week, prospective, observational cohort study comprising patients from public and private health services across Brazil, who chronically use antimalarials for the treatment of immune-mediated rheumatic diseases, osteoarthritis, or chikungunya-related arthropathy. A total of six sequential phone interviews were scheduled during the COVID-19 outbreak in five different regions of Brazil. Information regarding social, epidemiological, and demographic data, as well as details about rheumatic diseases, antimalarials, comorbidities, and concomitant medication, is being recorded using a specific online form in the REDCap database. Symptoms suggestive of COVID-19, including fever, cough, dyspnea, anosmia, and dysgeusia, are being self-reported and collected via phone interviews. Our main outcomes are hospitalization, need of intensive care unit, and death., Results: Recruitment began at the end of March 2020, and the inclusion was done during an 8-week period (from March 29 to May 17) with a total of 10,443 individuals enrolled at baseline, 5166 of whom have rheumatic diseases, from 23 tertiary rheumatology centers across 97 Brazilian cities. Data analysis is scheduled to begin after all inclusion data have been collected., Conclusions: This study, which includes a large sample of chronic antimalarial users, will allow us to explore whether SARS-CoV-2 infection may be associated with immune-mediated rheumatic diseases and long-term antimalarial usage., Trial Registration: Brazilian Registry of Clinical Trials RBR-9KTWX6; http://www.ensaiosclinicos.gov.br/rg/RBR-9ktwx6/., International Registered Report Identifier (irrid): DERR1-10.2196/23532., (©Ana Gomides, Gilda Ferreira, Adriana Kakehasi, Marcus Lacerda, Cláudia Marques, Licia Mota, Eduardo Paiva, Gecilmara Pileggi, José Provenza, Edgard Reis-Neto, Vanderson Sampaio, Ricardo Xavier, Marcelo Pinheiro. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 14.10.2020.)

Published
2020
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