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225 results on '"Pina, Trinitario"'

1. Cutaneous Vasculitis

Author

Prieto-Peña, Diana, Pina, Trinitario, González-Gay, Miguel A., Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, Vaglio, Augusto, Editorial Board Member, Boiardi, Luigi, editor, and Muratore, Francesco, editor

Published
2021
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4. Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

Author

Bartoloni, Elena, Gonzalez-Gay, Miguel A., Scirè, Carlo, Castaneda, Santos, Gerli, Roberto, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Govoni, Marcello, Furini, Federica, Pina, Trinitario, Iannone, Florenzo, Giannini, Margherita, Nuño, Laura, Quartuccio, Luca, Ortego-Centeno, Norberto, Alunno, Alessia, Specker, Christopher, Montecucco, Carlomaurizio, Triantafyllias, Konstantinos, Balduzzi, Silvia, Sifuentes-Giraldo, Walter Alberto, Paolazzi, Giuseppe, Bravi, Elena, Schwarting, Andreas, Pellerito, Raffaele, Russo, Alessandra, Selmi, Carlo, Saketkoo, Lesley-Ann, Fusaro, Enrico, Parisi, Simone, Pipitone, Nicolò, Franceschini, Franco, Cavazzana, Ilaria, Neri, Rossella, Barsotti, Simone, Codullo, Veronica, and Cavagna, Lorenzo

Published
2017
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5. Anti-TNF-α therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients

Author

Riancho-Zarrabeitia, Leyre, Calvo-Río, Vanesa, Blanco, Ricardo, Mesquida, Marina, Adan, Alfredo M., Herreras, José M., Aparicio, Ángel, Peiteado-Lopez, Diana, Cordero-Coma, Miguel, García Serrano, José Luis, Ortego-Centeno, Norberto, Maíz, Olga, Blanco, Ana, Sánchez-Bursón, Juan, González-Suárez, Senén, Fonollosa, Alejandro, Santos-Gómez, Montserrat, González-Vela, Carmen, Loricera, Javier, Pina, Trinitario, and González-Gay, Miguel A.

Published
2015
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7. Tocilizumab in giant cell arteritis: Multicenter open-label study of 22 patients

Author

Loricera, Javier, Blanco, Ricardo, Hernández, José L., Castañeda, Santos, Mera, Antonio, Pérez-Pampín, Eva, Peiró, Enriqueta, Humbría, Alicia, Calvo-Alén, Jaime, Aurrecoechea, Elena, Narváez, Javier, Sánchez-Andrade, Amalia, Vela, Paloma, Díez, Elvira, Mata, Cristina, Lluch, Pau, Moll, Concepción, Hernández, Íñigo, Calvo-Río, Vanesa, Ortiz-Sanjuán, Francisco, González-Vela, Carmen, Pina, Trinitario, and González-Gay, Miguel Á.

Published
2015
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13. Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy

Author

Pina, Trinitario, Genre, Fernanda, Lopez-Mejias, Raquel, Armesto, Susana, Ubilla, Begoña, Mijares, Veronica, Dierssen-Sotos, Trinidad, Corrales, Alfonso, Gonzalez-Lopez, Marcos A., Gonzalez-Vela, Maria C., Blanco, Ricardo, Hernández, Jose L., Llorca, Javier, and Gonzalez-Gay, Miguel A.

Published
2016
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15. Brief Report: Association of HLA–DRB1*01 With IgA Vasculitis (Henoch-Schönlein)

Author

López-Mejías, Raquel, Genre, Fernanda, Pérez, Belén Sevilla, Castañeda, Santos, Ortego-Centeno, Norberto, Llorca, Javier, Ubilla, Begoña, Remuzgo-Martínez, Sara, Mijares, Verónica, Pina, Trinitario, Calvo-Río, Vanesa, Márquez, Ana, Sala-Icardo, Luis, Miranda-Filloy, José A., Conde-Jaldón, Marta, Ortiz-Fernández, Lourdes, Rubio, Esteban, Luque, Manuel León, Blanco-Madrigal, Juan M., Galíndez-Aguirregoikoa, Eva, González-Vela, Carmen M., Ocejo-Vinyals, Gonzalo J., Escribano, Francisca González, Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel A.

Published
2015
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17. Single-organ cutaneous small-vessel vasculitis according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides: a study of 60 patients from a series of 766 cutaneous vasculitis cases

Author

Loricera, Javier, Blanco, Ricardo, Ortiz-Sanjuán, Francisco, Hernández, José L., Pina, Trinitario, González-Vela, M. Carmen, Calvo-Río, Vanesa, Rueda-Gotor, Javier, Alvarez, Lino, González-López, Marcos A., Marcellán, María, and González-Gay, Miguel A.

Published
2015
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19. Efficacy of Tocilizumab in Conventional Treatment–Refractory Adult-Onset Stillʼs Disease: Multicenter Retrospective Open-Label Study of Thirty-Four Patients

Author

Ortiz-Sanjuán, Francisco, Blanco, Ricardo, Calvo-Rio, Vanesa, Narvaez, Javier, Rubio Romero, Esteban, Olivé, Alejandro, Castañeda, Santos, Gallego Flores, Adela, Hernández, Victoria M., Mata, Cristina, Ros Vilamajo, Inmaculada, Sifuentes Giraldo, Walter Alberto, Caracuel, Miguel A., Freire, Mercedes, Gómez Arango, Catalina, Llobet, José, Manrique Arija, Sara, Marras, Carlos, Moll-Tuduri, Concepción, Plasencia-Rodriguez, Chamaida, Roselló, Rosa, Urruticoechea, Ana, Velloso-Feijoo, Maria L., del Blanco, Jordi, González-Vela, Carmen M., Rueda-Gotor, Javier, Pina, Trinitario, Loricera, Javier, and González-Gay, Miguel A.

Published
2014
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25. Invasive cryptococcosis and adalimumab treatment

Author

Horcajada, Juan P., Pena, Jose L., Martinez-Taboada, Victor M., Pina, Trinitario, Belaustegui, Isabel, Cano, Maria Eliecer, Garcia-Palomo, Daniel, and Farinas, M. Carmen

Subjects
Health aspects, Clinical trials -- Health aspects, Infection -- Health aspects, Immunosuppressive agents -- Health aspects, Infection control -- Health aspects, Biological products -- Health aspects, Antiarthritic agents -- Health aspects
Abstract

To the Editor: Tumor necrosis factor-a (TNF-a) antagonists are immunosuppressants that have shown efficacy in treating inflammatory disorders. However, a recent meta-analysis of controlled trials has shown evidence of increased [...]

Published
2007

32. Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis

Author

Rueda-Gotor, Javier, primary, Genre, Fernanda, additional, Corrales, Alfonso, additional, Blanco, Ricardo, additional, Fuentevilla, Patricia, additional, Portilla, Virginia, additional, Expósito, Rosa, additional, Arnaiz, Cristina Mata, additional, Pina, Trinitario, additional, González-Juanatey, Carlos, additional, Rodriguez-Rodriguez, Luis, additional, and González-Gay, Miguel A., additional

Published
2018
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33. Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis

Author

Remuzgo-Martínez, Sara, primary, Genre, Fernanda, additional, Castañeda, Santos, additional, Corrales, Alfonso, additional, Moreno-Fresneda, Pablo, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Portilla, Virginia, additional, González-Vela, Jesús, additional, Pina, Trinitario, additional, Ocejo-Vinyals, Gonzalo, additional, Irure-Ventura, Juan, additional, Blanco, Ricardo, additional, Martín, Javier, additional, Llorca, Javier, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel A., additional

Published
2017
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34. A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis

Author

López-Mejías, Raquel, primary, Carmona, F. David, additional, Castañeda, Santos, additional, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Sevilla-Perez, Belén, additional, Ortego-Centeno, Norberto, additional, Llorca, Javier, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Miranda-Filloy, José A., additional, Navas Parejo, Antonio, additional, de Argila, Diego, additional, Aragües, Maximiliano, additional, Rubio, Esteban, additional, Luque, Manuel León, additional, Blanco-Madrigal, Juan María, additional, Galíndez-Aguirregoikoa, Eva, additional, Jayne, David, additional, Blanco, Ricardo, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2017
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35. Significant sE-Selectin levels reduction after 6 months of anti-TNF-α therapy in non-diabetic patients with moderate-to-severe psoriasis

Author

Genre, Fernanda, primary, Armesto, Susana, additional, Corrales, Alfonso, additional, López-Mejías, Raquel, additional, Remuzgo-Martínez, Sara, additional, Pina, Trinitario, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Martín-Varillas, José Luis, additional, Rueda-Gotor, Javier, additional, Portilla, Virginia, additional, Dierssen-Sotos, Trinidad, additional, González-López, Marcos Antonio, additional, González-Vela, María del Carmen, additional, Blanco, Ricardo, additional, Llorca, Javier, additional, Hernández, José Luis, additional, and González-Gay, Miguel Ángel, additional

Published
2017
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36. Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

Author

López-Mejías, Raquel, Corrales, Alfonso, Vicente, Esther, Robustillo-Villarino, Montserrat, González-Juanatey, Carlos, Llorca, Javier, Genre, Fernanda, Remuzgo-Martínez, Sara, Dierssen-Sotos, Trinidad, Miranda-Filloy, J. A., Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Ferraz-Amaro, Iván, Gómez-Vaquero, C., Balsa, Alejandro, López-Longo, Francisco Javier, Carreira, P., González-Álvaro, Isidoro, Ocejo-Vinyals, J. Gonzalo, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Castañeda, Santos, Martín, J., González-Gay, M. A., López-Mejías, Raquel, Corrales, Alfonso, Vicente, Esther, Robustillo-Villarino, Montserrat, González-Juanatey, Carlos, Llorca, Javier, Genre, Fernanda, Remuzgo-Martínez, Sara, Dierssen-Sotos, Trinidad, Miranda-Filloy, J. A., Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Ferraz-Amaro, Iván, Gómez-Vaquero, C., Balsa, Alejandro, López-Longo, Francisco Javier, Carreira, P., González-Álvaro, Isidoro, Ocejo-Vinyals, J. Gonzalo, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Castañeda, Santos, Martín, J., and González-Gay, M. A.

Abstract

A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.

Published
2017

37. Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

Author

López-Mejías, Raquel, primary, Corrales, Alfonso, additional, Vicente, Esther, additional, Robustillo-Villarino, Montserrat, additional, González-Juanatey, Carlos, additional, Llorca, Javier, additional, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Dierssen-Sotos, Trinidad, additional, Miranda-Filloy, José A., additional, Huaranga, Marco A. Ramírez, additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Raya, Enrique, additional, Mijares, Verónica, additional, Ubilla, Begoña, additional, Ferraz-Amaro, Iván, additional, Gómez-Vaquero, Carmen, additional, Balsa, Alejandro, additional, López-Longo, Francisco J., additional, Carreira, Patricia, additional, González-Álvaro, Isidoro, additional, Ocejo-Vinyals, J. Gonzalo, additional, Rodríguez-Rodríguez, Luis, additional, Fernández-Gutiérrez, Benjamín, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2017
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38. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, González-Juanatey, Carlos, Robustillo-Villarino, Montserrat, Llorca, Javier, Corrales, Alfonso, Vicente, Esther, Miranda-Filloy, J. A., Magro, César, Tejera Segura, Beatriz, Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Mínguez Sánchez, María D., Gómez-Vaquero, C., Balsa, Alejandro, Pascual-Salcedo, Dora, López-Longo, Francisco Javier, Carreira, P., González-Álvaro, Isidoro, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Ferraz-Amaro, Iván, Castañeda, Santos, Martín, J., González-Gay, M. A., López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, González-Juanatey, Carlos, Robustillo-Villarino, Montserrat, Llorca, Javier, Corrales, Alfonso, Vicente, Esther, Miranda-Filloy, J. A., Magro, César, Tejera Segura, Beatriz, Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Mínguez Sánchez, María D., Gómez-Vaquero, C., Balsa, Alejandro, Pascual-Salcedo, Dora, López-Longo, Francisco Javier, Carreira, P., González-Álvaro, Isidoro, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Ferraz-Amaro, Iván, Castañeda, Santos, Martín, J., and González-Gay, M. A.

Abstract

Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA

Published
2016

39. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, González-Juanatey, Carlos, additional, Robustillo-Villarino, Montserrat, additional, Llorca, Javier, additional, Corrales, Alfonso, additional, Vicente, Esther, additional, Miranda-Filloy, José A., additional, Magro, César, additional, Tejera-Segura, Beatriz, additional, Ramírez Huaranga, Marco A., additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Raya, Enrique, additional, Mijares, Verónica, additional, Ubilla, Begoña, additional, Mínguez Sánchez, María D., additional, Gómez-Vaquero, Carmen, additional, Balsa, Alejandro, additional, Pascual-Salcedo, Dora, additional, López-Longo, Francisco J., additional, Carreira, Patricia, additional, González-Álvaro, Isidoro, additional, Rodríguez-Rodríguez, Luis, additional, Fernández-Gutiérrez, Benjamín, additional, Ferraz-Amaro, Iván, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2016
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41. Anti-tumor necrosis factor-alpha therapy improves endothelial function and arterial stiffness in patients with moderate to severe psoriasis: A 6-month prospective study

Author

Pina, Trinitario, primary, Corrales, Alfonso, additional, Lopez-Mejias, Raquel, additional, Armesto, Susana, additional, Gonzalez-Lopez, Marcos A., additional, Gómez-Acebo, Ines, additional, Ubilla, Begoña, additional, Remuzgo-Martínez, Sara, additional, Gonzalez-Vela, M. Carmen, additional, Blanco, Ricardo, additional, Hernández, Jose L., additional, Llorca, Javier, additional, and Gonzalez-Gay, Miguel A., additional

Published
2016
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42. Colaboradores

Author

Ahn, Christine S., Asemota, Eseosa, Avarbock, Andrew, Baquerizo Nole, Katherine L., Barrett, Terry L., Belum, Viswanath Reddy, Bolognia, Jean L., Bowen, Anneli R., Bradish, Joshua R., Braunstein, Inbal, Callen, Jeffrey P., Camisa, Charles, Cerroni, Lorenzo, Cipriano, Sarah D., Cooper, Dennis L., Cowen, Edward W., Elston, Dirk M., English, Joseph C., III, Femia, Alisa, Fett, Nicole, Ghazi, Elizabeth, González-Gay, Miguel A., Goodman, Warren T., Greer, Kenneth E., Gudjonsson, Johann E., Haemel, Anna, Hansen, Christopher B., Harp, Joanna, Heelan, Kara, Herron, Mark D., Heymann, Warren R., Hou, Zhe, Huang, William W., Jackson, J. Mark, Jorizzo, Joseph L., Kirsner, Robert S., Kollipara, Ramya, Kovarik, Carrie, Lacouture, Mario E., Le, Stephanie T., Leiferman, Kristin M., Leslie, Kieron S., Lipner, Shari R., Loss, Manisha J., Maiberger, Mary P., McMichael, Amy, Merola, Joseph F., Micheletti, Robert G., Molina-Ruiz, Ana M., Noe, Megan H., Norton, Scott A., Nunley, Julia R., Owen, Cindy England, Piette, Warren W., Pina, Trinitario, Poh-Fitzpatrick, Maureen B., Requena, Luis, Rosen, Ted, Rosenbach, Misha A., Salkey, Kimberly S., Schadt, Courtney R., Schaffer, Julie V., Scher, Richard K., Schlosser, Bethanee J., Schwarzenberger, Kathryn, Shah, Sheevam, Shear, Neil H., Tharp, Michael D., Tyring, Stephen K., Vleugels, Ruth Ann, Wanat, Karolyn A., Wolverton, Stephen E., Wright, Natalie A., Wu, Jashin J., Yosipovitch, Gil, Zang, Julie B., Zone, John J., and Zwald, Fiona

Published
2018
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43. The Framingham Score and the Systematic Coronary Risk Evaluation at Low Cutoff Values Are Useful Surrogate Markers of High-risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

Author

Dessein, Patrick H., primary, Corrales, Alfonso, additional, Lopez-Mejias, Raquel, additional, Solomon, Ahmed, additional, Woodiwiss, Angela J., additional, Llorca, Javier, additional, Norton, Gavin R., additional, Genre, Fernanda, additional, Blanco, Ricardo, additional, Pina, Trinitario, additional, Gonzalez-Juanatey, Carlos, additional, Tsang, Linda, additional, and Gonzalez-Gay, Miguel A., additional

Published
2016
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44. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy

Author

Hernández, José L., primary, López-Mejías, Raquel, additional, Blanco, Ricardo, additional, Pina, Trinitario, additional, Ruiz, Sheila, additional, Sierra, Isabel, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, González-López, Marcos A., additional, Armesto, Susana, additional, Corrales, Alfonso, additional, Pons, Enar, additional, Fuentevilla, Patricia, additional, González-Vela, Carmen, additional, and González-Gay, Miguel Á., additional

Published
2016
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45. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Robustillo-Villarino, Montserrat, García-Bermúdez, Mercedes, Llorca, Javier, Corrales, Alfonso, González-Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, J. A., Mijares, Verónica, Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Ramírez Huaranga, Marco A., Mínguez Sánchez, María D., Tejera Segura, Beatriz, Ferraz-Amaro, Iván, Vicente, Esther, Carmona, F.D., Castañeda, Santos, Martín, J., González-Gay, M. A., López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Robustillo-Villarino, Montserrat, García-Bermúdez, Mercedes, Llorca, Javier, Corrales, Alfonso, González-Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, J. A., Mijares, Verónica, Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan-José, Ramírez Huaranga, Marco A., Mínguez Sánchez, María D., Tejera Segura, Beatriz, Ferraz-Amaro, Iván, Vicente, Esther, Carmona, F.D., Castañeda, Santos, Martín, J., and González-Gay, M. A.

Abstract

OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.71 ± 0.14 mm versus 0.76 ± 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean ± SD: 0.73 ± 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean ± SD: 0.72 ± 0.16 mm versus 0.75 ± 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.

Published
2015

46. Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

Author

García-Bermúdez, Mercedes, López-Mejías, Raquel, Genre, Fernanda, Castañeda, Santos, Corrales, Alfonso, Llorca, Javier, González-Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, J. A., Pina, Trinitario, Gómez-Vaquero, C., Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Balsa, A., Pascual-Salcedo, Dora, López-Longo, Francisco Javier, Carreira, P., Blanco, Ricardo, Martín, J., González-Gay, M. A., García-Bermúdez, Mercedes, López-Mejías, Raquel, Genre, Fernanda, Castañeda, Santos, Corrales, Alfonso, Llorca, Javier, González-Juanatey, Carlos, Ubilla, Begoña, Miranda-Filloy, J. A., Pina, Trinitario, Gómez-Vaquero, C., Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, B., Balsa, A., Pascual-Salcedo, Dora, López-Longo, Francisco Javier, Carreira, P., Blanco, Ricardo, Martín, J., and González-Gay, M. A.

Abstract

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.

Published
2015

47. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Robustillo-Villarino, Montserrat, additional, García-Bermúdez, Mercedes, additional, Llorca, Javier, additional, Corrales, Alfonso, additional, González-Juanatey, Carlos, additional, Ubilla, Begoña, additional, Miranda-Filloy, José A., additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Ramírez Huaranga, Marco A., additional, Mínguez Sánchez, María D., additional, Tejera Segura, Beatriz, additional, Ferraz-Amaro, Iván, additional, Vicente, Esther, additional, Carmona, F. David, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2015
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48. Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Pérez, Belén Sevilla, additional, Castañeda, Santos, additional, Llorca, Javier, additional, Ortego-Centeno, Norberto, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Calvo-Río, Vanesa, additional, Palmou, Natalia, additional, Miranda-Filloy, José A., additional, Parejo, Antonio Navas, additional, Argila, Diego, additional, Sánchez-Pérez, Javier, additional, Rubio, Esteban, additional, Luque, Manuel León, additional, Blanco-Madrigal, Juan María, additional, Galíndez-Aguirregoikoa, Eva, additional, Ocejo-Vinyals, J. Gonzalo, additional, Martín, Javier, additional, Blanco, Ricardo, additional, and González-Gay, Miguel A., additional

Published
2015
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49. Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate‐to‐severe psoriasis undergoing anti‐tumor necrosis factor‐α therapy

Author

Pina, Trinitario, primary, Genre, Fernanda, additional, Lopez‐Mejias, Raquel, additional, Armesto, Susana, additional, Ubilla, Begoña, additional, Mijares, Veronica, additional, Dierssen‐Sotos, Trinidad, additional, Corrales, Alfonso, additional, Gonzalez‐Lopez, Marcos A., additional, Gonzalez‐Vela, Maria C., additional, Blanco, Ricardo, additional, Hernández, Jose L., additional, Llorca, Javier, additional, and Gonzalez‐Gay, Miguel A., additional

Published
2015
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50. Efficacy of Anakinra in Refractory Adult-Onset Still's Disease

Author

Ortiz-Sanjuán, Francisco, primary, Blanco, Ricardo, additional, Riancho-Zarrabeitia, Leyre, additional, Castañeda, Santos, additional, Olivé, Alejandro, additional, Riveros, Anne, additional, Velloso-Feijoo, María.L., additional, Narváez, Javier, additional, Jiménez-Moleón, Inmaculada, additional, Maiz-Alonso, Olga, additional, Ordóñez, Carmen, additional, Bernal, José A., additional, Hernández, María V., additional, Sifuentes-Giraldo, Walter A., additional, Gómez-Arango, Catalina, additional, Galíndez-Agirregoikoa, Eva, additional, Blanco-Madrigal, Juan, additional, Ortiz-Santamaria, Vera, additional, del Blanco-Barnusell, Jordi, additional, De Dios, Juan R., additional, Moreno, Mireia, additional, Fiter, Jordi, additional, Riscos, Marina de los, additional, Carreira, Patricia, additional, Rodriguez-Valls, María J., additional, González-Vela, M. Carmen, additional, Calvo-Río, Vanesa, additional, Loricera, Javier, additional, Palmou-Fontana, Natalia, additional, Pina, Trinitario, additional, Llorca, Javier, additional, and González-Gay, Miguel A., additional

Published
2015
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