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BESTARD-CAMPS, JOAN. (trans. Robert Pitt (Explor. Anthrop. Ser.). xviii, 213 pp., illus., tables, bibliogr. New York, Oxford: Berg, 1991. 27.50 £ What's in a relative? is a study in the [...]

Caffeine is an integral part of beverages, food, and medications. Severe intoxication of caffeine is rare, and reports are even scarcer. However, over-the-counter, unregulated sale of performance-enhancing compounds, such as caffeine, turns high-dose consumption into a real concern. Severe intoxication may be fatal, usually by malignant cardiac arrhythmia. We report a case of a 23-year-old university student who accidentally consumed about 100 times the amount present in an expresso of anhydrous caffeine., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Pina Cabral et al.)

Tumor lysis syndrome (TLS) is an oncological emergency that most frequently occurs in hematological and high-turnover solid neoplasia. Its incidence in solid, slowly proliferating neoplasia is unclear, primarily because of few published case reports. TLS may be triggered by chemotherapy or infection, or may spontaneously arise. Here, we present a review of the literature and a case of a 58-year-old male patient with prostate cancer who developed spontaneous TLS., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Pina Cabral et al.)

After the injection of DDAVP in 39 non-anaesthetized dogs (0.4 micrograms/kg) factor VIII:C activity rose to 145% of baseline values (p less than 0.0001) and the fibrinolytic potential of euglobulin precipitate rose to 196% (p less than 0.0001). The injection of DDAVP was repeated three times in each dog of a group of good responder animals at weekly intervals, but after: A) Pentobarbital anesthesia (30 mg/kg)--the increase of factor VIII:C was reduced from 164% to 116% (n = 11; p less than 0.0005) and the increase in fibrinolytic activity was reduced from 270% to 192% (n = 11; p less than 0.05). B) Injection of propranolol (1 mg/kg)--the increase of factor VIII:C was reduced from 167% to 110% (n = 13; p less than 0.0005) and there was no significant decrease of fibrinolytic activity (n = 13; n.s.) C) Splenectomy--the increase of factor VIII:C was reduced from 166% to 122% (n = 10; p less than 0.0005) and fibrinolytic activity was not significantly changed from 196% to 256% (n = 9; n.s.). There were no statistically significant differences in the increases of factor VIII:C and fibrinolytic potential of euglobulin precipitate after repeating only the injection of DDAVP three times in the same animal at weekly intervals (n = 5; n.s.). We conclude that the increases in factor VIII:C and fibrinolytic activities observed after DDAVP infusion in the dog are due to different mechanisms of action.(ABSTRACT TRUNCATED AT 250 WORDS)