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763 results on '"Pinedo, Herbert M"'

2. Correction to: Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Author

Lou, Hong, Gharzouzi, Eduardo, Guerra, Sarita Polo, Fokom Domgue, Joël, Sawitzke, Julie, Villagran, Guillermo, Garland, Lisa, Boland, Joseph F., Wagner, Sarah, Rosas, Héctor, Troxler, Jami, McMillen, Heidi, Kessing, Bailey, Alvirez, Enrique, Castillo, Miriam, Morales, Hesler, Argueta, Victor, Rosingh, Andert, van Aerde-van Nunen, Femke J. H. B., Lopez, Griselda, Pinedo, Herbert M., Schiffman, Mark, Dean, Michael, and Orozco, Roberto

Published
2020
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3. Supplementary Table 2 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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4. Supplementary Figure 2 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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5. Supplementary Table 1 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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6. Supplementary Figure 1 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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7. Supplementary Figure 3 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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8. Supplementary Figure 4 from Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

Author

de Weger, Vincent A., primary, Turksma, Annelies W., primary, Voorham, Quirinus J.M., primary, Euler, Zelda, primary, Bril, Herman, primary, van den Eertwegh, Alfons J., primary, Bloemena, Elisabeth, primary, Pinedo, Herbert M., primary, Vermorken, Jan B., primary, van Tinteren, Harm, primary, Meijer, Gerrit A., primary, and Hooijberg, Erik, primary

Published
2023
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9. Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Author

Lou, Hong, Gharzouzi, Eduardo, Guerra, Sarita Polo, Domgue, Joël Fokom, Sawitzke, Julie, Villagran, Guillermo, Garland, Lisa, Boland, Joseph F., Wagner, Sarah, Rosas, Héctor, Troxler, Jami, McMillen, Heidi, Kessing, Bailey, Alvirez, Enrique, Castillo, Miriam, Morales, Hesler, Argueta, Victor, Rosingh, Andert, van Aerde-van Nunen, Femke J. H. B., Lopez, Griselda, Pinedo, Herbert M., Schiffman, Mark, Dean, Michael, and Orozco, Roberto

Published
2018
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12. Thymidine Phosphorylase in Angiogenesis and Drug Resistance : Homology with platelet-derived endothelial cell growth factor

Author

Peters, Godefridus J., de Bruin, Michiel, Fukushima, Masakazu, van Triest, Baukelien, Hoekman, Klaas, Pinedo, Herbert M., Ackland, Stephen P., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Zoref-Shani, Esther, editor, and Sperling, Oded, editor

Published
2002
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13. The Role of Deoxycytidine Kinase in Gemcitabine Cytotoxicity

Author

van der Wilt, Clasina L., Kroep, Judith R., Bergman, Andries M., Loves, Willem J.P., Alvarez, Enrique, Talianidis, Iannnis, Eriksson, Staffan, van Groeningen, Cees J., Pinedo, Herbert M., Peters, Godefridus J., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Zoref-Shani, Esther, editor, and Sperling, Oded, editor

Published
2002
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15. Molecular Pathways of Drug Resistance

Author

Tolis, Christos, Ferreira, Carlos G., Pinedo, Herbert M., Giaccone, Giuseppe, Bronchud, Miguel H., editor, Foote, Mary Ann, editor, Peters, William P., editor, and Robinson, Murray O., editor

Published
2000
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16. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

Author

van den Eertwegh, Alfons JM, Versluis, Jurjen, van den Berg, H Pieter, Santegoets, Saskia JAM, van Moorselaar, R Jeroen A, van der Sluis, Tim M, Gall, Helen E, Harding, Thomas C, Jooss, Karin, Lowy, Israel, Pinedo, Herbert M, Scheper, Rik J, Stam, Anita GM, von Blomberg, B Mary E, de Gruijl, Tanja D, Hege, Kristen, Sacks, Natalie, and Gerritsen, Winald R

Published
2012
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34. Blood-based kinase activity profiling:A potential predictor of response to immune checkpoint inhibition in metastatic cancer

Author

Hurkmans, Daan P., Verdegaal, Els M.E., Hogan, Sabrina A., De Wijn, Rik, Hovestad, Lies, Van Den Heuvel, Dianne M.A., Ruijtenbeek, Rob, Welters, Marij J.P., Van Brakel, Mandy, Basak, Edwin A., Pinedo, Herbert M., Lamers, Cor H.J., Van De Werken, Harmen J.G., Groten, John P., Debets, Reno, Levesque, Mitchell P., Dummer, Reinhard, Kapiteijn, Ellen, Mathijssen, Ron H.J., Aerts, Joachim G.J.V., Van Der Burg, Sjoerd H., Hurkmans, Daan P., Verdegaal, Els M.E., Hogan, Sabrina A., De Wijn, Rik, Hovestad, Lies, Van Den Heuvel, Dianne M.A., Ruijtenbeek, Rob, Welters, Marij J.P., Van Brakel, Mandy, Basak, Edwin A., Pinedo, Herbert M., Lamers, Cor H.J., Van De Werken, Harmen J.G., Groten, John P., Debets, Reno, Levesque, Mitchell P., Dummer, Reinhard, Kapiteijn, Ellen, Mathijssen, Ron H.J., Aerts, Joachim G.J.V., and Van Der Burg, Sjoerd H.

Abstract

Background Many cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clinical outcome. Methods Here a total of 160 patients with advanced melanoma or non-small-cell lung cancer (NSCLC), treated with anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) or anti-programmed cell death 1 (anti-PD-1), were divided into five discovery and cross-validation cohorts. The kinase activity profile was generated by analyzing phosphorylation of peripheral blood mononuclear cell lysates in a microarray comprising of 144 peptides derived from sites that are substrates for protein tyrosine kinases. Binary grouping into patients with or without clinical benefit was based on Response Evaluation Criteria in Solid Tumors V.1.1. Predictive models were trained using partial least square discriminant analysis (PLS-DA), performance of the models was evaluated by estimating the correct classification rate (CCR) using cross-validation. Results The kinase phosphorylation signatures segregated responders from non-responders by differences in canonical pathways governing T-cell migration, infiltration and co-stimulation. PLS-DA resulted in a CCR of 100% and 93% in the anti-CTLA-4 and anti-PD1 melanoma discovery cohorts, respectively. Cross-validation cohorts to estimate the accuracy of the predictive models showed CCRs of 83% for anti-CTLA-4 and 78% or 68% for anti-PD-1 in melanoma or NSCLC, respectively. Conclusion Blood-based kinase activity profiling for response prediction to immune checkpoint inhibitors in melanoma and NSCLC revealed increased kinase activity in pathways associated with T-cell function and led to a classification model with a highly accurate classification rate in cross-validation groups. The predictive value of kinase activity profiling is prospectively verified in an ongoing trial.

Published
2020

36. Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer

Author

Hurkmans, Daan P, primary, Verdegaal, Els M E, additional, Hogan, Sabrina A, additional, de Wijn, Rik, additional, Hovestad, Lies, additional, van den Heuvel, Dianne M A, additional, Ruijtenbeek, Rob, additional, Welters, Marij J P, additional, van Brakel, Mandy, additional, Basak, Edwin A, additional, Pinedo, Herbert M, additional, Lamers, Cor H J, additional, van de Werken, Harmen J G, additional, Groten, John P, additional, Debets, Reno, additional, Levesque, Mitchell P, additional, Dummer, Reinhard, additional, Kapiteijn, Ellen, additional, Mathijssen, Ron H J, additional, Aerts, Joachim G J V, additional, and van der Burg, Sjoerd H, additional

Published
2020
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39. Making use of the primary tumour

Author

Baars, Arnold, Buter, Jan, and Pinedo, Herbert M.

Subjects
Tumors -- Research, Surgery -- Usage, Cancer -- Care and treatment, Metastasis -- Care and treatment, Immunity -- Physiological aspects, Adjuvants, Pharmaceutic -- Usage, Immunotherapy -- Research, Biological sciences
Published
2003

49. The Role of Deoxycytidine Kinase in Gemcitabine Cytotoxicity

Author

van der Wilt, Clasina L., primary, Kroep, Judith R., additional, Bergman, Andries M., additional, Loves, Willem J.P., additional, Alvarez, Enrique, additional, Talianidis, Iannnis, additional, Eriksson, Staffan, additional, van Groeningen, Cees J., additional, Pinedo, Herbert M., additional, and Peters, Godefridus J., additional

Published
2002
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