Search

Your search keyword '"Pinker-Domenig, Katja"' showing total 180 results
Start Over Author "Pinker-Domenig, Katja"
180 results on '"Pinker-Domenig, Katja"'

3. Diagnostic value of diffusion-weighted imaging with synthetic b-values in breast tumors: comparison with dynamic contrast-enhanced and multiparametric MRI.

Author

Daimiel Naranjo, Isaac, Lo Gullo, Roberto, Saccarelli, Carolina, Thakur, Sunitha, Bitencourt, Almir, Jochelson, Maxine, Sevilimedu, Varadan, Martinez, Danny, Pinker-Domenig, Katja, and Morris, Elizabeth

Subjects
Breast tumors, Diagnostic imaging, Diffusion magnetic resonance imaging, Echo-planar imaging, Image analysis, Breast, Breast Density, Breast Neoplasms, Contrast Media, Diffusion Magnetic Resonance Imaging, Female, Humans, Mammography, Multiparametric Magnetic Resonance Imaging, Retrospective Studies, Sensitivity and Specificity
Abstract

OBJECTIVES: To assess DWI for tumor visibility and breast cancer detection by the addition of different synthetic b-values. METHODS: Eighty-four consecutive women who underwent a breast-multiparametric-MRI (mpMRI) with enhancing lesions on DCE-MRI (BI-RADS 2-5) were included in this IRB-approved retrospective study from September 2018 to March 2019. Three readers evaluated DW acquired b-800 and synthetic b-1000, b-1200, b-1500, and b-1800 s/mm2 images for lesion visibility and preferred b-value based on lesion conspicuity. Image quality (1-3 scores) and breast composition (BI-RADS) were also recorded. Diagnostic parameters for DWI were determined using a 1-5 malignancy score based on qualitative imaging parameters (acquired + preferred synthetic b-values) and ADC values. BI-RADS classification was used for DCE-MRI and quantitative ADC values + BI-RADS were used for mpMRI. RESULTS: Sixty-four malignant (average = 23 mm) and 39 benign (average = 8 mm) lesions were found in 80 women. Although b-800 achieved the best image quality score, synthetic b-values 1200-1500 s/mm2 were preferred for lesion conspicuity, especially in dense breast. b-800 and synthetic b-1000/b-1200 s/mm2 values allowed the visualization of 84-90% of cancers visible with DCE-MRI performing better than b-1500/b-1800 s/mm2. DWI was more specific (86.3% vs 65.7%, p < 0.001) but less sensitive (62.8% vs 90%, p < 0.001) and accurate (71% vs 80.7%, p = 0.003) than DCE-MRI for breast cancer detection, where mpMRI was the most accurate modality accounting for less false positive cases. CONCLUSION: The addition of synthetic b-values enhances tumor conspicuity and could potentially improve tumor visualization particularly in dense breast. However, its supportive role for DWI breast cancer detection is still not definite. KEY POINTS: • The addition of synthetic b-values (1200-1500 s/mm2) to acquired DWI afforded a better lesion conspicuity without increasing acquisition time and was particularly useful in dense breasts. • Despite the use of synthetic b-values, DWI was less sensitive and accurate than DCE-MRI for breast cancer detection. • A multiparametric MRI modality still remains the best approach having the highest accuracy for breast cancer detection and thus reducing the number of unnecessary biopsies.

Published
2021

4. A rapid volume of interest-based approach of radiomics analysis of breast MRI for tumor decoding and phenotyping of breast cancer.

Author

Demircioglu, Aydin, Grueneisen, Johannes, Ingenwerth, Marc, Hoffmann, Oliver, Pinker-Domenig, Katja, Haubold, Johannes, Forsting, Michael, Nensa, Felix, Umutlu, Lale, and Morris, Elizabeth

Subjects
Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast, Breast Neoplasms, Female, Humans, Image Interpretation, Computer-Assisted, Machine Learning, Magnetic Resonance Imaging, Middle Aged, Neoplasm Grading, Retrospective Studies, Time Factors
Abstract

BACKGROUND: Recently, radiomics has emerged as a non-invasive, imaging-based tissue characterization method in multiple cancer types. One limitation for robust and reproducible analysis lies in the inter-reader variability of the tumor annotations, which can potentially cause differences in the extracted feature sets and results. In this study, the diagnostic potential of a rapid and clinically feasible VOI (Volume of Interest)-based approach to radiomics is investigated to assess MR-derived parameters for predicting molecular subtype, hormonal receptor status, Ki67- and HER2-Expression, metastasis of lymph nodes and lymph vessel involvement as well as grading in patients with breast cancer. METHODS: A total of 98 treatment-naïve patients (mean 59.7 years, range 28.0-89.4) with BI-RADS 5 and 6 lesions who underwent a dedicated breast MRI prior to therapy were retrospectively included in this study. The imaging protocol comprised dynamic contrast-enhanced T1-weighted imaging and T2-weighted imaging. Tumor annotations were obtained by drawing VOIs around the primary tumor lesions followed by thresholding. From each segmentation, 13.118 quantitative imaging features were extracted and analyzed with machine learning methods. Validation was performed by 5-fold cross-validation with 25 repeats. RESULTS: Predictions for molecular subtypes obtained AUCs of 0.75 (HER2-enriched), 0.73 (triple-negative), 0.65 (luminal A) and 0.69 (luminal B). Differentiating subtypes from one another was highest for HER2-enriched vs triple-negative (AUC 0.97), followed by luminal B vs triple-negative (0.86). Receptor status predictions for Estrogen Receptor (ER), Progesterone Receptor (PR) and Hormone receptor positivity yielded AUCs of 0.67, 0.69 and 0.69, while Ki67 and HER2 Expressions achieved 0.81 and 0.62. Involvement of the lymph vessels could be predicted with an AUC of 0.8, while lymph node metastasis yielded an AUC of 0.71. Models for grading performed similar with an AUC of 0.71 for Elston-Ellis grading and 0.74 for the histological grading. CONCLUSION: Our preliminary results of a rapid approach to VOI-based tumor-annotations for radiomics provides comparable results to current publications with the perks of clinical suitability, enabling a comprehensive non-invasive platform for breast tumor decoding and phenotyping.

Published
2020

10. Supplementary Figure 1 from Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Author

Mayerhoefer, Marius E., primary, Karanikas, Georgios, primary, Kletter, Kurt, primary, Prosch, Helmut, primary, Kiesewetter, Barbara, primary, Skrabs, Cathrin, primary, Porpaczy, Edit, primary, Weber, Michael, primary, Pinker-Domenig, Katja, primary, Berzaczy, Dominik, primary, Hoffmann, Martha, primary, Sillaber, Christian, primary, Jaeger, Ulrich, primary, Müllauer, Leonhard, primary, Simonitsch-Klupp, Ingrid, primary, Dolak, Werner, primary, Gaiger, Alexander, primary, Ubl, Philipp, primary, Lukas, Julius, primary, and Raderer, Markus, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Table 1 from Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Author

Mayerhoefer, Marius E., primary, Karanikas, Georgios, primary, Kletter, Kurt, primary, Prosch, Helmut, primary, Kiesewetter, Barbara, primary, Skrabs, Cathrin, primary, Porpaczy, Edit, primary, Weber, Michael, primary, Pinker-Domenig, Katja, primary, Berzaczy, Dominik, primary, Hoffmann, Martha, primary, Sillaber, Christian, primary, Jaeger, Ulrich, primary, Müllauer, Leonhard, primary, Simonitsch-Klupp, Ingrid, primary, Dolak, Werner, primary, Gaiger, Alexander, primary, Ubl, Philipp, primary, Lukas, Julius, primary, and Raderer, Markus, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure Legends from Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Author

Mayerhoefer, Marius E., primary, Karanikas, Georgios, primary, Kletter, Kurt, primary, Prosch, Helmut, primary, Kiesewetter, Barbara, primary, Skrabs, Cathrin, primary, Porpaczy, Edit, primary, Weber, Michael, primary, Pinker-Domenig, Katja, primary, Berzaczy, Dominik, primary, Hoffmann, Martha, primary, Sillaber, Christian, primary, Jaeger, Ulrich, primary, Müllauer, Leonhard, primary, Simonitsch-Klupp, Ingrid, primary, Dolak, Werner, primary, Gaiger, Alexander, primary, Ubl, Philipp, primary, Lukas, Julius, primary, and Raderer, Markus, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Table 2 from Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Author

Mayerhoefer, Marius E., primary, Karanikas, Georgios, primary, Kletter, Kurt, primary, Prosch, Helmut, primary, Kiesewetter, Barbara, primary, Skrabs, Cathrin, primary, Porpaczy, Edit, primary, Weber, Michael, primary, Pinker-Domenig, Katja, primary, Berzaczy, Dominik, primary, Hoffmann, Martha, primary, Sillaber, Christian, primary, Jaeger, Ulrich, primary, Müllauer, Leonhard, primary, Simonitsch-Klupp, Ingrid, primary, Dolak, Werner, primary, Gaiger, Alexander, primary, Ubl, Philipp, primary, Lukas, Julius, primary, and Raderer, Markus, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure 2 from Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Author

Mayerhoefer, Marius E., primary, Karanikas, Georgios, primary, Kletter, Kurt, primary, Prosch, Helmut, primary, Kiesewetter, Barbara, primary, Skrabs, Cathrin, primary, Porpaczy, Edit, primary, Weber, Michael, primary, Pinker-Domenig, Katja, primary, Berzaczy, Dominik, primary, Hoffmann, Martha, primary, Sillaber, Christian, primary, Jaeger, Ulrich, primary, Müllauer, Leonhard, primary, Simonitsch-Klupp, Ingrid, primary, Dolak, Werner, primary, Gaiger, Alexander, primary, Ubl, Philipp, primary, Lukas, Julius, primary, and Raderer, Markus, primary

Published
2023
Full Text
View/download PDF

21. Breast MRI: EUSOBI recommendations for women’s information

Author

Mann, Ritse M., Balleyguier, Corinne, Baltzer, Pascal A., Bick, Ulrich, Colin, Catherine, Cornford, Eleanor, Evans, Andrew, Fallenberg, Eva, Forrai, Gabor, Fuchsjäger, Michael H., Gilbert, Fiona J., Helbich, Thomas H., Heywang-Köbrunner, Sylvia H., Camps-Herrero, Julia, Kuhl, Christiane K., Martincich, Laura, Pediconi, Federica, Panizza, Pietro, Pina, Luis J., Pijnappel, Ruud M., Pinker-Domenig, Katja, Skaane, Per, Sardanelli, Francesco, and for the European Society of Breast Imaging (EUSOBI), with language review by Europa Donna–The European Breast Cancer Coalition

Published
2015
Full Text
View/download PDF

24. Multiparametric Integrated 18F-FDG PET/MRI-Based Radiomics for Breast Cancer Phenotyping and Tumor Decoding

Author

Umutlu, Lale, primary, Kirchner, Julian, additional, Bruckmann, Nils Martin, additional, Morawitz, Janna, additional, Antoch, Gerald, additional, Ingenwerth, Marc, additional, Bittner, Ann-Kathrin, additional, Hoffmann, Oliver, additional, Haubold, Johannes, additional, Grueneisen, Johannes, additional, Quick, Harald H., additional, Rischpler, Christoph, additional, Herrmann, Ken, additional, Gibbs, Peter, additional, and Pinker-Domenig, Katja, additional

Published
2021
Full Text
View/download PDF

25. Multidimensional Diffusion Magnetic Resonance Imaging for Characterization of Tissue Microstructure in Breast Cancer Patients: A Prospective Pilot Study

Author

Naranjo, Isaac Daimiel, primary, Reymbaut, Alexis, additional, Brynolfsson, Patrik, additional, Lo Gullo, Roberto, additional, Bryskhe, Karin, additional, Topgaard, Daniel, additional, Giri, Dilip D., additional, Reiner, Jeffrey S., additional, Thakur, Sunitha B., additional, and Pinker-Domenig, Katja, additional

Published
2021
Full Text
View/download PDF

26. Characterization of the transmission of structured light in scattering media

Author

Suprano, Alessia, primary, Gianani, Ilaria, additional, Giordani, Taira, additional, Spagnolo, Nicolò, additional, Pinker-Domenig, Katja, additional, Klemm, Uwe, additional, Gorpas, Dimitris, additional, Ntziachristos, Vasilis, additional, Biton, Netanel, additional, Kupferman, Judy, additional, Arnon, Shlomi, additional, and Sciarrino, Fabio, additional

Published
2021
Full Text
View/download PDF

27. Diagnostic value of diffusion-weighted imaging with synthetic b-values in breast tumors: comparison with dynamic contrast-enhanced and multiparametric MRI

Author

Daimiel Naranjo, Isaac, primary, Lo Gullo, Roberto, additional, Saccarelli, Carolina, additional, Thakur, Sunitha B., additional, Bitencourt, Almir, additional, Morris, Elizabeth A., additional, Jochelson, Maxine S., additional, Sevilimedu, Varadan, additional, Martinez, Danny F., additional, and Pinker-Domenig, Katja, additional

Published
2020
Full Text
View/download PDF

30. Technical Note: Scintillation well counters and particle counting digital autoradiography devices can be used to detect activities associated with genomic profiling adequacy of biopsy specimens obtained after a low activity 18 F-FDG injection

Author

Kirov, Assen S., primary, Fanchon, Louise M., additional, Seiter, Daniel, additional, Czmielewski, Christian, additional, Russell, James, additional, Dogan, Snjezana, additional, Carlin, Sean, additional, Pinker-Domenig, Katja, additional, Yorke, Ellen, additional, Schmidtlein, C. Ross, additional, Boyko, Vitaly, additional, Fujisawa, Sho, additional, Manova-Todorova, Katia, additional, Zanzonico, Pat, additional, Dauer, Lawrence, additional, Deasy, Joseph O., additional, Humm, John L., additional, and Solomon, Stephen, additional

Published
2018
Full Text
View/download PDF

33. Erratum to “The breast lesion excision system (BLES) under stereotactic guidance cannot be used as a therapeutic tool in the excision of small areas of microcalcifications in the breast” [EURR 93C (2017) 252–257]

Author

Milos, Ruxandra-Iulia, primary, Bernathova, Maria, additional, Baltzer, Pascal A., additional, Pinker-Domenig, Katja, additional, Kapetas, Panagiotis, additional, Rudas, Margaretha, additional, and Helbich, Thomas H., additional

Published
2017
Full Text
View/download PDF

37. Dynamical graph theory networks techniques for the analysis of sparse connectivity networks in dementia

Author

Tahmassebi, Amirhessam, primary, Pinker-Domenig, Katja, additional, Wengert, Georg, additional, Lobbes, Marc, additional, Stadlbauer, Andreas, additional, Romeroa, Francisco J., additional, Morales, Diego P., additional, Castillo, Encarnacion, additional, Garcia, Antonio, additional, Botella, Guillermo, additional, and Meyer-Bäse, Anke, additional

Published
2017
Full Text
View/download PDF

38. The driving regulators of the connectivity protein network of brain malignancies

Author

Tahmassebi, Amirhessam, primary, Pinker-Domenig, Katja, additional, Wengert, Georg, additional, Lobbes, Marc, additional, Stadlbauer, Andreas, additional, Wildburger, Norelle C., additional, Romeroa, Francisco J., additional, Morales, Diego P., additional, Castillo, Encarnacion, additional, Garcia, Antonio, additional, Botella, Guillermo, additional, and Meyer-Bäse, Anke, additional

Published
2017
Full Text
View/download PDF

47. Head-to-head comparison of PI-RADS v2 and PI-RADS v1

Author

Polanec, Stephan, primary, Helbich, Thomas H., additional, Bickel, Hubert, additional, Pinker-Domenig, Katja, additional, Georg, Dietmar, additional, Shariat, Shahrokh F., additional, Aulitzky, Wolfgang, additional, Susani, Martin, additional, and Baltzer, Pascal A., additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results