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Your search keyword '"Pinto-da-Silva, Lucia Helena"' showing total 13 results
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13 results on '"Pinto-da-Silva, Lucia Helena"'

1. A novel protocol for the synthesis of 1,2,4-oxadiazoles active against trypanosomatids and drug-resistant leukemia cell lines

Author

Pitasse-Santos, Paulo, Salustiano, Eduardo, Pena, Raynna Bittencourt, Chaves, Otavio Augusto, Fonseca, Leonardo Marques da, da Costa, Kelli Monteiro, Nascimento Santos, Carlos Antonio do, Reis, Jhenifer Santos Dos, Santos, Marcos Andre Rodrigues da Costa, Previato, Jose Osvaldo, Previato, Lucia Mendonca, Freire-de-Lima, Leonardo, Romeiro, Nelilma Correia, Pinto-da-Silva, Lucia Helena, Freire-de-Lima, Celio G, Decote-Ricardo, Debora, and Freire-de-Lima, Marco Edilson

Published
2022

3. Inhibition of Microbicidal Activity of Canine Macrophages DH82 Cell Line by Capsular Polysaccharides from Cryptococcus neoformans

Author

LaRocque-de-Freitas, Isabel F., primary, da Silva-Junior, Elias Barbosa, additional, Gemieski, Leticia Paixão, additional, da Silva Dias Lima, Beatriz, additional, Diniz-Lima, Israel, additional, de Carvalho Vivarini, Aislan, additional, Lopes, Ulisses G., additional, Freire-de-Lima, Leonardo, additional, Morrot, Alexandre, additional, Previato, José Osvaldo, additional, Mendonça-Previato, Lucia, additional, Pinto-da-Silva, Lucia Helena, additional, Freire-de-Lima, Celio G., additional, and Decote-Ricardo, Debora, additional

Published
2024
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8. DH82 Canine and RAW264.7 Murine Macrophage Cell Lines Display Distinct Activation Profiles Upon Interaction With Leishmania infantum and Leishmania amazonensis

Author

Nadaes, Natalia Rocha, primary, Silva da Costa, Leandro, additional, Santana, Raissa Couto, additional, LaRocque-de-Freitas, Isabel Ferreira, additional, Vivarini, Áislan de Carvalho, additional, Soares, Deivid Costa, additional, Wardini, Amanda Brito, additional, Gazos Lopes, Ulisses, additional, Saraiva, Elvira M., additional, Freire-de-Lima, Celio Geraldo, additional, Decote-Ricardo, Debora, additional, and Pinto-da-Silva, Lucia Helena, additional

Published
2020
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12. Cooperation between Apoptotic and Viable Metacyclics Enhances the Pathogenesis of Leishmaniasis

Author

Wanderley, João Luiz Mendes, primary, Pinto da Silva, Lucia Helena, additional, Deolindo, Poliana, additional, Soong, Lynn, additional, Borges, Valéria Matos, additional, Prates, Deboraci Brito, additional, de Souza, Ana Paula Almeida, additional, Barral, Aldina, additional, Balanco, José Mario de Freitas, additional, Nascimento, Michelle Tanny Cunha do, additional, Saraiva, Elvira Maria, additional, and Barcinski, Marcello André, additional

Published
2009
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13. Resveratrol Is Active against Leishmania amazonensis: In VitroEffect of Its Association with Amphotericin B

Author

Ferreira, Christian, Soares, Deivid Costa, Nascimento, Michelle Tanny Cunha do, Pinto-da-Silva, Lucia Helena, Sarzedas, Carolina Galvão, Tinoco, Luzineide Wanderley, and Saraiva, Elvira Maria

Abstract

ABSTRACTResveratrol is a polyphenol found in black grapes and red wine and has many biological activities. In this study, we evaluated the effect of resveratrol alone and in association with amphotericin B (AMB) against Leishmania amazonensis. Our results demonstrate that resveratrol possesses both antipromastigote and antiamastigote effects, with 50% inhibitory concentrations (IC50s) of 27 and 42 μM, respectively. The association of resveratrol with AMB showed synergy for L. amazonensisamastigotes, as demonstrated by the mean sums of fractional inhibitory index concentration (mean ΣFIC) of 0.483, although for promastigotes, this association was indifferent. Treatment with resveratrol increased the percentage of promastigotes in the sub-G0/G1phase of the cell cycle, reduced the mitochondrial potential, and showed an elevated choline peak and CH2-to-CH3ratio in the nuclear magnetic resonance (NMR) spectroscopy analysis; all these features indicate parasite death. Resveratrol also decreased the activity of the enzyme arginase in uninfected and infected macrophages with and without stimulation with interleukin-4 (IL-4), also implicating arginase inhibition in parasite death. The anti-Leishmaniaeffect of resveratrol and its potential synergistic association with AMB indicate that these compounds should be subjected to further studies of drug association therapy in vivo.

Published
2014
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