1. Relation of plasma carnitine and aminotransferases to alcohol dose and time of dependence
- Author
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Piotr Zwierz, Sławomir Dariusz Szajda, Sylwia Chojnowska, Ewa Skorupa, Marek Szczepański, Alina Kępka, Agnieszka Ochocińska, and Napoleon Waszkiewicz
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Health (social science) ,Urinary system ,Alcohol abuse ,Alcohol ,Toxicology ,digestive system ,Biochemistry ,Excretion ,03 medical and health sciences ,Behavioral Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Carnitine ,Internal medicine ,medicine ,Humans ,Aspartate Aminotransferases ,Liver injury ,Ethanol ,business.industry ,Alcohol dependence ,Alanine Transaminase ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,030227 psychiatry ,Alcoholism ,Endocrinology ,Neurology ,chemistry ,Case-Control Studies ,business ,Biomarkers ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Serum aspartate, alanine aminotransferases (AST, ALT), and plasma carnitine are all indirect biomarkers of alcohol abuse. Carnitine transfers long-chain fatty acids from cytoplasm to mitochondria for β-oxidation. The aim of the study was to determine the relationship between daily alcohol intake, time of alcohol dependence, plasma carnitine, and serum aminotransferases.We studied 26 men who were addicted for 2-30 years, consuming ethanol from 75 to 700 g/day (alcoholic group), as well as 17 healthy men (control group).In alcoholics, compared to the controls, we found: a significant increase in serum: AST (p = 0.0014), ALT (p = 0.0071), AST/ALT ratio (p 0.000); significantly lower plasma free carnitine (FC) (p = 0.0316) and total carnitine (TC) (p = 0.0349); and a significant negative correlation between FC (r = -0.6200; RIn the alcoholic group, there was an increase in serum activity of AST, ALT, and AST/ALT ratio that confirms liver injury. In addition, we found low plasma FC and TC, which may indicate damage to mitochondrial β-oxidation caused by alcohol metabolites. The significantly higher plasma FC and TC in patients consuming the most, compared to patients consuming smaller doses of alcohol, may be caused by a lower carnitine demand of injured liver cells, decreased urinary carnitine excretion by impaired renal tubules, and leakage of carnitine into the blood from damaged muscles by the higher quantities of alcohol. The negative correlation between carnitine concentration and time of alcohol dependence may suggest the potential use of carnitine for treatment of alcohol abuse.
- Published
- 2019
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