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Your search keyword '"Piotrowski, Joshua T."' showing total 14 results
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14 results on '"Piotrowski, Joshua T."'

1. WASH

Author

Piotrowski, Joshua T., Billadeau, Daniel D., and Choi, Sangdun, editor

Published
2018
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4. Wyatt

Author

Piotrowski, Joshua T., primary and Billadeau, Daniel D., additional

Published
2012
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7. Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Author

Walpole, Glenn F.W., primary, Plumb, Jonathan D., additional, Chung, Daniel, additional, Tang, Brandon, additional, Boulay, Benoit, additional, Osborne, Douglas G., additional, Piotrowski, Joshua T., additional, Catz, Sergio D., additional, Billadeau, Daniel D., additional, Grinstein, Sergio, additional, and Jaumouillé, Valentin, additional

Published
2020
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14. Inactivation of Rho GTPases by Burkholderia cenocepaciaInduces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Author

Walpole, Glenn F.W., Plumb, Jonathan D., Chung, Daniel, Tang, Brandon, Boulay, Benoit, Osborne, Douglas G., Piotrowski, Joshua T., Catz, Sergio D., Billadeau, Daniel D., Grinstein, Sergio, and Jaumouillé, Valentin

Abstract

Burkholderia cenocepaciais an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B. cenocepaciacan survive inside infected macrophages within the B. cenocepacia-containing vacuole (BcCV) and to elicit a severe inflammatory response. By inactivating the host macrophage Rho GTPases, the bacterial effector TecA causes depolymerization of the cortical actin cytoskeleton. In this study, we find that B. cenocepaciainduces the formation of large cytosolic F-actin clusters in infected macrophages. Cluster formation requires the nucleation-promoting factor WASH, the Arp2/3 complex, and TecA. Inactivation of Rho GTPases by bacterial toxins is necessary and sufficient to induce the formation of the cytosolic actin clusters. By hijacking WASH and Arp2/3 activity, B. cenocepaciadisrupts interactions with the endolysosomal system, thereby delaying the maturation of the BcCV.

Published
2020
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