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Your search keyword '"Piquet, Léo"' showing total 16 results
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16 results on '"Piquet, Léo"'

1. Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1

Author

Gest, Caroline, Sena, Sandra, Dif, Lydia, Neaud, Véronique, Loesch, Robin, Dugot-Senant, Nathalie, Paysan, Lisa, Piquet, Léo, Robbe, Terezinha, Allain, Nathalie, Dembele, Doulaye, Guettier, Catherine, Bioulac-Sage, Paulette, Rullier, Anne, Le Bail, Brigitte, Grosset, Christophe F., Saltel, Frédéric, Lagrée, Valérie, Colnot, Sabine, and Moreau, Violaine

Published
2023
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5. Antagonism between wild-type and mutant b-catenin controls hepatoblastoma differentiation via Fascin-1

Author

Gest, Caroline, primary, Sena, Sandra, additional, Dif, Lydia, additional, Neaud, Véronique, additional, Loesch, Robin, additional, Dugot-Senant, Nathalie, additional, Paysan, Lisa, additional, Piquet, Léo, additional, Robbe, Terezinha, additional, Allain, Nathalie, additional, Dembele, Doulaye, additional, Guettier, Catherine, additional, Bioulac-Sage, Paulette, additional, Rullier, Anne, additional, Le Bail, Brigitte, additional, Grosset, Christophe F., additional, Saltel, Frédéric, additional, Lagrée, Valérie, additional, Colnot, Sabine, additional, and Moreau, Violaine, additional

Published
2023
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8. The ß-catenin-target Fascin-1, altering hepatocyte differentiation, is a new marker of immature cells in hepatoblastomas

Author

Gest, Caroline, primary, Sena, Sandra, additional, Neaud, Véronique, additional, Loesch, Robin, additional, Dugot-Senant, Nathalie, additional, Paysan, Lisa, additional, Piquet, Léo, additional, Robbe, Terezinha, additional, Allain, Nathalie, additional, Dembele, Doulaye, additional, Guettier, Catherine, additional, Bioulac-Sage, Paulette, additional, Bail, Brigitte Le, additional, Grosset, Christophe F., additional, Saltel, Frédéric, additional, Lagrée, Valérie, additional, Colnot, Sabine, additional, and Moreau, Violaine, additional

Published
2021
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9. Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Author

Roy, Vincent, Magne, Brice, Vaillancourt-Audet, Maude, Blais, Mathieu, Chabaud, Stéphane, Grammond, Emil, Piquet, Léo, Fradette, Julie, Laverdière, Isabelle, Moulin, Véronique J., Landreville, Solange, Germain, Lucie, Auger, François A., Gros-Louis, François, and Bolduc, Stéphane

Subjects
Article Subject
Abstract

Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.

Published
2020
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16. Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.

Author

Binarné, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, and Moreau, Violaine

Subjects
*CELL migration, *CANCER cell migration, *GTPASE-activating protein, *CARRIER proteins, *LIVER cancer
Abstract

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migration. In this study, we investigated the molecular processes responsible for p190A targeting to actin protrusions. By analyzing the subcellular localization of truncated versions of p190A in hepatocellular carcinoma cells, we identified a novel functional p190A domain: the protrusion localization sequence (PLS) necessary and sufficient for p190A targeting to leading edges. Interestingly, the PLS is also required for the negative regulation of p190A RhoGAP activity. Further, we show that the F-actin binding protein cortactin binds the PLS and is required for p190A targeting to protrusions. Lastly, we demonstrate that cancer-associated mutations in PLS affect p190A localization and function, as well as tumor cell migration. Altogether, our data unveil a new mechanism of regulation of p190A in migrating tumor cells. [ABSTRACT FROM AUTHOR]

Published
2016
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