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Background It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up. Methods In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4.1–10.8)]. Results In this extended analysis, M1, S1 and T1–T2 lesions as well as the whole MEST score were independently related with the combined endpoint (P Conclusion Long-term follow-up analyses of the VALIGA cohort showed that the independent relationship between kidney biopsy findings and the risk of progression towards kidney failure in IgAN remains unchanged across all age groups and decades after the renal biopsy.

This paper describes the fourth edition of Lifelog challenges in ImageCLEF 2020. In this edition, the Lifelog challenges consist of two tasks which are Lifelog Moments Retrieval (LMRT) and Sport Per- formance Lifelog (SPLL). While the Lifelog Moments Retrieval chal- lenge follows the same format of the previous edition, its data is a larger multimodal dataset based on the merger of three previous NT- CIR Lifelog datasets, which contain approximately 191,439 images with corresponding visual concepts and other related metadata. The Sport Performance Lifelog, which is a brand new challenge, is composed of three subtasks that focus on predicting the expected performance of ath- letes who trained for a sport event. In summary, the ImageCLEF Lifelog 2020 receives 50 runs from six teams in total with competitive results. This publication has emanated from research supported in party by research grants from Irish Research Council (IRC) under Grant Number GOIPG/2016/741 and Science Foundation Ireland under grant numbers SFI/12/RC/2289 and SFI/13/RC/2106.

This paper describes the participation of the Organiser Team in the ImageCLEFlifelog 2019 Solve My Life Puzzle (Puzzle) and Lifelog Moment Retrieval (LMRT) tasks. We proposed to use LIFER 2.0, an enhanced version of LIFER, which was an interactive retrieval system for personal lifelog data. We utilised LIFER 2.0 with some additional visual features, obtained by using traditional visual bag-of-words, to solve the Puzzle task, while with the LMRT, we applied LIFER 2.0 only with the provided information. The results on both tasks confirmed that by using faceted filter and context browsing, a user can gain insights from their personal lifelog by employing very simple interactions. These results also serve as baselines for other approaches in the ImageCLEFlifelog 2019 challenge to compare with. publishedVersion

Background The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS. Results All glomerular lesions (M, E, C and S) assessed by local pathologists were independently associated with the decision to administer CS/IS therapy, while the severity of tubulointerstitial lesions was not. Reproducibility between local and central pathologists was moderate for S (segmental sclerosis) and T (tubular atrophy/interstitial fibrosis), and poor for M (mesangial hypercellularity), E (endocapillary hypercellularity) and C (crescents). Local pathologists found statistically more of each lesion, except for the S lesion, which was more frequent with central review. Disagreements were more likely to occur when the proportion of glomeruli affected was low. The M lesion, assessed by central pathologists, correlated better with the severity of the disease at presentation and discriminated better with outcomes. In contrast, the E lesion, evaluated by local pathologists, correlated better with the clinical presentation and outcomes when compared with central review. Both C and S lesions, when discordant between local and central pathologists, had a clinical phenotype intermediate to double absent lesions (milder disease) and double present (more severe). Conclusion We conclude that differences in the scoring of MEST-C criteria between local pathologists and a central reviewer have a significant impact on the prognostic value of the Oxford Classification. Since the decision to offer immunosuppressive therapy in this cohort was intimately associated with the MEST-C score, this study indicates a need for a more detailed guidance for pathologists in the scoring of IgAN biopsies.

Background: The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS. Results: All glomerular lesions (M, E, C and S) assessed by local pathologists were independently associated with the decision to administer CS/IS therapy, while the severity of tubulointerstitial lesions was not. Reproducibility between local and central pathologists was moderate for S (segmental sclerosis) and T (tubular atrophy/interstitial fibrosis), and poor for M (mesangial hypercellularity), E (endocapillary hypercellularity) and C (crescents). Local pathologists found statistically more of each lesion, except for the S lesion, which was more frequent with central review. Disagreements were more likely to occur when the proportion of glomeruli affected was low. The M lesion, assessed by central pathologists, correlated better with the severity of the disease at presentation and discriminated better with outcomes. In contrast, the E lesion, evaluated by local pathologists, correlated better with the clinical presentation and outcomes when compared with central review. Both C and S lesions, when discordant between local and central pathologists, had a clinical phenotype intermediate to double absent lesions (milder disease) and double present (more severe). Conclusion: We conclude that differences in the scoring of MEST-C criteria between local pathologists and a central reviewer have a significant impact on the prognostic value of the Oxford Classification. Since the decision to offer immunosuppressive therapy in this cohort was intimately associated with the MEST-C score, this study indicates a need for a more detailed guidance for pathologists in the scoring of IgAN biopsies. © 2018 The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Benchmarking in Multimedia and Retrieval related research fields has a long tradition and important position within the community. Benchmarks such as the MediaEval Multimedia Benchmark or CLEF are well established and also served by the community. One major goal of these competitions beside of comparing different methods and approaches is also to create or promote new interesting research directions within multimedia. For example the Medico task at MediaEval with the goal of medical related multimedia analysis. Although lifelogging creates a lot of attention in the community which is shown by several workshops and special session hosted about the topic. Despite of that there exist also some lifelogging related benchmarks. For example the previous edition of the lifelogging task at ImageCLEF. The last years ImageCLEFlifelog task was well received but had some barriers that made it difficult for some researchers to participate (data size, multi modal features, etc.) The ImageCLEFlifelog 2018 tries to overcome these problems and make the task accessible for an even broader audience (eg, pre-extracted features are provided). Furthermore, the task is divided into two subtasks (challenges). The two challenges are lifelog moment retrieval (LMRT) and the Activities of Daily Living understanding (ADLT). All in all seven teams participated with a total number of 41 runs which was an significant increase compared to the previous year.

This paper describes the participation of Organizer Team in the ImageCLEFlifelog 2017 Retrieval and Summarization subtasks. In this paper, we propose some baseline approaches, using only the provided information, which require different involvement levels from the users. With these baselines we target at providing references for other approaches that aim to solve the problems of lifelog retrieval and summarization.

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The book deals with the role of financial analysts as information providers in financial markets. Chapter one introduces the debate between behavioral finance and traditional finance with regard to market efficiency, in the light of recent financial scandals. Chapter two uses a mix of behavioral finance and linguistic analysis to analyze the reports of financial analysts on the S&P 500 to discern if they are able to anticipate shocks and crises. Chapter three compares studies related to the potential conflicts of interest faced by analysts, the market reaction to changes in recommendations, and the investment value of portfolio strategies based on analysts' consensus. Chapter four deals with analysts' distorted valuations of internet stocks during the dotcom bubble and comparing it with recent evidences on IPOs in the hi-tech sector. The book is the result of the collaboration of the authors and of their researches in the last ten years, starting from the papers of the last five years and ending up with the most recent evidence.