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1. Echocardiographic and clinical features of patients developing prosthesis‐patient mismatch after transcatheter aortic valve replacement: Insights from the Recovery-TAVR registry

Author

Bruno, Francesco, Rampone, Joao Matteo, Islas, Fabian, Gorla, Riccardo, Gallone, Guglielmo, Melillo, Francesco, Leone, Pier Pasquale, Cimaglia, Paolo, Pastore, Maria Concetta, Franzone, Anna, Landra, Federico, Scudeler, Luca, Jimenez-Quevedo, Pilar, Viva, Tommaso, Piroli, Francesco, Bragato, Renato, Trichilo, Michele, Degiovanni, Anna, Salizzoni, Stefano, Ilardi, Federica, Andreis, Alessandro, Nombela-Franco, Luis, Tusa, Maurizio, Toselli, Marco, Conrotto, Federico, Montorfano, Matteo, Manzo, Rachele, Cameli, Matteo, Patti, Giuseppe, Stefanini, Giulio, Testa, Luca, La Torre, Michele, Giannini, Francesco, Agricola, Eustachio, Escaned, Javier, De Filippo, Ovidio, De Ferrari, Gaetano M., and D'Ascenzo, Fabrizio

Published
2024
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2. Percutaneous coronary intervention versus coronary artery surgery for left main disease according to lesion site: A meta-analysis

Author

De Filippo, Ovidio, Di Franco, Antonino, Boretto, Paolo, Bruno, Francesco, Cusenza, Vincenzo, Desalvo, Paolo, Demetres, Michelle, Saglietto, Andrea, Franchin, Luca, Piroli, Francesco, Marengo, Giorgio, Elia, Edoardo, Falk, Volkmar, Conrotto, Federico, Doenst, Torsten, Rinaldi, Mauro, De Ferrari, Gaetano Maria, D'Ascenzo, Fabrizio, and Gaudino, Mario

Published
2023
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3. Impacto de los tratamientos hipolipemiantes en los resultados cardiovasculares según la puntuación de calcio coronario. Revisión sistemática y metanálisis

Author

Gallone, Guglielmo, Elia, Edoardo, Bruno, Francesco, Angelini, Filippo, Franchin, Luca, Bocchino, Pier Paolo, Piroli, Francesco, Annone, Umberto, Montabone, Andrea, Marengo, Giorgio, Bertaina, Maurizio, De Filippo, Ovidio, Baldetti, Luca, Palmisano, Anna, Serafini, Alessandro, Esposito, Antonio, Depaoli, Alessandro, D’ascenzo, Fabrizio, Fonio, Paolo, and De Ferrari, Gaetano Maria

Published
2022
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4. Impact of computed-tomography defined sarcopenia on outcomes of older adults undergoing transcatheter aortic valve implantation

Author

Gallone, Guglielmo, Depaoli, Alessandro, D'Ascenzo, Fabrizio, Tore, Davide, Allois, Luca, Bruno, Francesco, Casale, Maurizio, Atzeni, Francesco, De Lio, Giulia, Bocchino, Pier Paolo, Piroli, Francesco, Angelini, Filippo, Angelini, Andrea, Scudeler, Luca, De Lio, Francesca, Andreis, Alessandro, Salizzoni, Stefano, La Torre, Michele, Conrotto, Federico, Rinaldi, Mauro, Fonio, Paolo, and De Ferrari, Gaetano M.

Published
2022
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8. De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a systematic review and network meta-analysis

Author

De Filippo, Ovidio, primary, Piroli, Francesco, additional, Bruno, Francesco, additional, Bocchino, Pier Paolo, additional, Saglietto, Andrea, additional, Franchin, Luca, additional, Angelini, Filippo, additional, Gallone, Guglielmo, additional, Rizzello, Giulia, additional, Ahmad, Mahmood, additional, Gasparini, Mauro, additional, Chatterjee, Saurav, additional, De Ferrari, Gaetano Maria, additional, and D'Ascenzo, Fabrizio, additional

Published
2024
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9. Efficacy and safety of left atrial appendage closure compared with oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials and propensity-matched studies

Author

Franchin, Luca, primary, Piroli, Francesco, additional, Demola, Pierluigi, additional, Mantovani, Francesca, additional, Iannaccone, Mario, additional, Manfredi, Roberto, additional, D’Ascenzo, Fabrizio, additional, Fortuni, Federico, additional, Ugo, Fabrizio, additional, Meucci, Francesco, additional, Navazio, Alessandro, additional, and Boccuzzi, Giacomo, additional

Published
2023
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11. Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study

Author

Franchin, Luca, Piroli, Francesco, D’Ascenzo, Fabrizio, Nuñez-Gil, Ivan, Wojakowski, Wojciech, Imori, Yoichi, Trabattoni, Daniela, Huczek, Zenon, Venuti, Giuseppe, Muscoli, Saverio, Montabone, Andrea, Rognoni, Andrea, Parma, Radoslaw, Figini, Filippo, Mitomo, Satoru, Quadri, Giorgio, Wańha, Wojciech, Cortese, Bernardo, De Filippo, Ovidio, Ryan, Nicola, Varbella, Ferdinando, Sheiban, Imad, Helft, Gerard, and De Ferrari, Gaetano M.

Published
2021
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12. Three-Dimensional Finger Test: A New Echocardiographic Method to Locate the Best Access Site During NeoChord Procedure

Author

Vairo, Alessandro, primary, Manai, Rossella, additional, Gaiero, Lorenzo, additional, Desalvo, Paolo, additional, Bellettini, Matteo, additional, Zaccaro, Lorenzo, additional, Rinaudo, Andrea, additional, Franchin, Luca, additional, Piroli, Francesco, additional, Bruno, Francesco, additional, Sebastiano, Viviana, additional, Cura Stura, Erik, additional, Barbero, Cristina, additional, Marro, Matteo, additional, Faletti, Riccardo, additional, Alunni, Gianluca, additional, De Ferrari, Gaetano Maria, additional, Rinaldi, Mauro, additional, and Salizzoni, Stefano, additional

Published
2023
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15. Two-Year clinical outcomes after coronary bifurcation stenting in older patients from Korea and Italy

Author

Kim, Ju Hyeon, primary, Franchin, Luca, additional, Hong, Soon Jun, additional, Cha, Jung-Joon, additional, Lim, Subin, additional, Joo, Hyung Joon, additional, Park, Jae Hyoung, additional, Yu, Cheol Woong, additional, Lim, Do-Sun, additional, Filippo, Ovidio De, additional, Gwon, Hyeon-Cheol, additional, Piroli, Francesco, additional, Kim, Hyo-Soo, additional, Wanha, Wojciech, additional, Choi, Ki Hong, additional, Song, Young Bin, additional, Patti, Giuseppe, additional, Nam, Chang-Wook, additional, Bruno, Francesco, additional, Kang, Jeehoon, additional, Bocchino, Pier Paolo, additional, De Ferrari, Gaetano Maria, additional, Koo, Bon-Kwon, additional, and D’Ascenzo, Fabrizio, additional

Published
2023
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16. De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a systematic review and network meta-analysis

Author

De Filippo, Ovidio, Piroli, Francesco, Bruno, Francesco, Bocchino, Pier Paolo, Saglietto, Andrea, Franchin, Luca, Angelini, Filippo, Gallone, Guglielmo, Rizzello, Giulia, Ahmad, Mahmood, Gasparini, Mauro, Chatterjee, Saurav, De Ferrari, Gaetano Maria, and D'Ascenzo, Fabrizio

Abstract

ObjectivesTo compare dual antiplatelet therapy (DAPT) de-escalation with five alternative DAPT strategies in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).DesignWe conducted a systematic review and network meta-analysis (NMA). Parallel-arm randomised controlled trials (RCTs) comparing DAPT strategies were included and arms of interest were compared via NMA. Partial ranking of each identified arm and for each investigated endpoint was also performed.Setting and participantsAdult patients with ACS (≥18 years) undergoing PCI with indications for DAPT.Search methodsA comprehensive search covered several databases (PubMed, Embase, Cochrane Central, MEDLINE, Conference Proceeding Citation Index-Science) from inception to 15 October 2023. Medical subject headings and keywords related to ACS, PCI and DAPT interventions were used. Reference lists of included studies were screened. Clinical trials registers were searched for ongoing or unpublished trials.InterventionsSix strategies were assessed: T1 arm: acetylsalicylic acid (ASA) and prasugrel for 12 months; T2 arm: ASA and low-dose prasugrel for 12 months; T3 arm: ASA and ticagrelor for 12 months; T4 arm: DAPT de-escalation (ASA+P2Y12 inhibitor for 1–3 months, then single antiplatelet therapy with potent P2Y12 inhibitor or DAPT with clopidogrel); T5 arm: ASA and clopidogrel for 12 months; T6 arm: ASA and clopidogrel for 3–6 months.Main outcome measuresPrimary outcome: Cardiovascular mortality. Secondary outcomes: bleeding events (all, major, minor), stent thrombosis (ST), stroke, myocardial infarction (MI), all-cause mortality, major adverse cardiovascular events (MACE).Results23 RCTs (75 064 patients with ACS) were included. No differences in cardiovascular mortality, all-cause death, recurrent MI or MACE were found when the six strategies were compared, although with different levels of certainty of evidence. ASA and clopidogrel for 12 or 3–6 months may result in a large increase of ST risk versus ASA plus full-dose prasugrel (OR 2.00, 95% CI 1.14 to 3.12, and OR 3.42, 95% CI 1.33 to 7.26, respectively; low certainty evidence for both comparisons). DAPT de-escalation probably results in a reduced risk of all bleedings compared with ASA plus full-dose 12-month prasugrel (OR 0.49, 95% CI 0.26 to 0.81, moderate-certainty evidence) and ASA plus 12-month ticagrelor (OR 0.52, 95% CI 0.33 to 0.75), while it may not increase the risk of ST. ASA plus 12-month clopidogrel may reduce all bleedings versus ASA plus full-dose 12-month prasugrel (OR 0.66, 95% CI 0.42 to 0.94, low certainty) and ASA plus 12-month ticagrelor (OR 0.70, 95% CI 0.52 to 0.89).ConclusionsDAPT de-escalation and ASA-clopidogrel regimens may reduce bleeding events compared with 12 months ASA and potent P2Y12 inhibitors. 3–6 months or 12-month aspirin-clopidogrel may increase ST risk compared with 12-month aspirin plus potent P2Y12 inhibitors, while DAPT de-escalation probably does not.

Published
2024
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18. Feasibility and reliability of comprehensive three-dimensional transoesophageal echocardiography screening process for transcatheter mitral valve replacement

Author

Piroli, Francesco, primary, Boccellino, Antonio, additional, Ingallina, Giacomo, additional, Rolando, Marco, additional, Melillo, Francesco, additional, Ancona, Francesco, additional, Stella, Stefano, additional, Biondi, Federico, additional, Palmisano, Anna, additional, Esposito, Antonio, additional, Denti, Paolo, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Castiglioni, Alessandro, additional, and Agricola, Eustachio, additional

Published
2023
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19. Stroke volume index and transvalvular flow rate trajectories in severe aortic stenosis treated with TAVR

Author

Gallone, Guglielmo, primary, Islas, Fabian, additional, Gorla, Riccardo, additional, Melillo, Francesco, additional, Leone, Pier Pasquale, additional, Cimaglia, Paolo, additional, Pastore, Maria Concetta, additional, Franzone, Anna, additional, Landra, Federico, additional, Bruno, Francesco, additional, Scudeler, Luca, additional, Jimenez-Quevedo, Pilar, additional, Viva, Tommaso, additional, Piroli, Francesco, additional, Bragato, Renato, additional, Trichilo, Michele, additional, Degiovanni, Anna, additional, Ilardi, Federica, additional, Andreis, Alessandro, additional, Nombela-Franco, Luis, additional, Maurizio, Tusa, additional, Toselli, Marco, additional, Conrotto, Federico, additional, Montorfano, Matteo, additional, Manzo, Rachele, additional, Cameli, Matteo, additional, Patti, Giuseppe, additional, Stefanini, Giulio, additional, Testa, Luca, additional, Giannini, Francesco, additional, Agricola, Eustachio, additional, Escaned, Javier, additional, D’Ascenzo, Fabrizio, additional, and De Ferrari, Gaetano M, additional

Published
2023
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20. Echocardiographic Parameters to Predict Malignant Events in Arrhythmic Mitral Valve Prolapse Population

Author

Vairo, Alessandro, primary, Desalvo, Paolo, additional, Rinaudo, Andrea, additional, Piroli, Francesco, additional, Tribuzio, Anna, additional, Ballatore, Andrea, additional, Marcelli, Gianluca, additional, Pistelli, Lorenzo, additional, Dusi, Veronica, additional, Montali, Nicolò, additional, Alunni, Gianluca, additional, Barbero, Cristina, additional, Salizzoni, Stefano, additional, Pocar, Marco, additional, Rinaldi, Mauro, additional, Gaita, Fiorenzo, additional, De Ferrari, Gaetano Maria, additional, and Giustetto, Carla, additional

Published
2023
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21. 1032 FEASIBILITY AND RELIABILITY OF COMPREHENSIVE THREE DIMENSIONAL TRANSESOPHAGEAL ECHOCARDIOGRAPHY SCREENING PROCESS FOR TRANSCATHETER MITRAL VALVE REPLACEMENT

Author

Boccellino, Antonio, primary, Piroli, Francesco, additional, Ingallina, Giacomo, additional, Rolando, Marco, additional, Melillo, Francesco, additional, Francesco, Ancona, additional, Stella, Stefano, additional, Biondi, Federico, additional, Baldetti, Luca, additional, Palmisano, Anna, additional, Esposito, Antonio, additional, Denti, Paolo, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Castiglioni, Alessandro, additional, and Agricola, Eustachio, additional

Published
2022
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22. Prediction of All-Cause Mortality Following Percutaneous Coronary Intervention in Bifurcation Lesions Using Machine Learning Algorithms

Author

Burrello, Jacopo, primary, Gallone, Guglielmo, additional, Burrello, Alessio, additional, Jahier Pagliari, Daniele, additional, Ploumen, Eline H., additional, Iannaccone, Mario, additional, De Luca, Leonardo, additional, Zocca, Paolo, additional, Patti, Giuseppe, additional, Cerrato, Enrico, additional, Wojakowski, Wojciech, additional, Venuti, Giuseppe, additional, De Filippo, Ovidio, additional, Mattesini, Alessio, additional, Ryan, Nicola, additional, Helft, Gérard, additional, Muscoli, Saverio, additional, Kan, Jing, additional, Sheiban, Imad, additional, Parma, Radoslaw, additional, Trabattoni, Daniela, additional, Giammaria, Massimo, additional, Truffa, Alessandra, additional, Piroli, Francesco, additional, Imori, Yoichi, additional, Cortese, Bernardo, additional, Omedè, Pierluigi, additional, Conrotto, Federico, additional, Chen, Shao-Liang, additional, Escaned, Javier, additional, Buiten, Rosaly A., additional, Von Birgelen, Clemens, additional, Mulatero, Paolo, additional, De Ferrari, Gaetano Maria, additional, Monticone, Silvia, additional, and D’Ascenzo, Fabrizio, additional

Published
2022
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23. Duration and kind of dual antiplatelet therapy for acute coronary syndrome patients: a network meta-analysis

Author

D'ASCENZO, Fabrizio, primary, DE FILIPPO, Ovidio, additional, ANGELINI, Filippo, additional, PIROLI, Francesco, additional, DE LIO, Giulia, additional, BOCCHINO, Pier Paolo, additional, BALDETTI, Luca, additional, MELILLO, Francesco, additional, CHIEFFO, Alaide, additional, SAGLIETTO, Andrea, additional, OMEDÈ, Pierluigi, additional, MONTEFUSCO, Antonio, additional, CONROTTO, Federico, additional, and DE FERRARI, Gaetano M., additional

Published
2022
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24. Safety and efficacy of different P2Y12 inhibitors in patients with acute coronary syndromes stratified by the PRAISE risk score: a multi-center study

Author

Patti, Giuseppe, D'Ascenzo, Fabrizio, De Filippo, Ovidio, Bruno, Francesco, Leonardi, Sergio, Chieffo, Alaide, Iannaccone, Mario, Liebetrau, Christoph, Manzano-Fernández, Sergio, Gallone, Guglielmo, Omedè, Pierluigi, Cerrato, Enrico, Kinnaird, Tim, Conrotto, Federico, Piroli, Francesco, Henriques, Jose Paulo Simao, Wańha, Wojciech, Elia, Edoardo, Dominguez-Rodriguez, Alberto, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, De Ferrari, Gaetano Maria, Cardiology, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Ticagrelor, Health Policy, dual antiplatelet therapy (DAPT), Myocardial Infarction, Hemorrhage, Acute coronary syndromes (ACS), P2Y12 inhibitors, artificial intelligence (AI), Clopidogrel, Treatment Outcome, Risk Factors, Acute coronary syndromes (ACSs), Purinergic P2Y Receptor Antagonists, Humans, Acute Coronary Syndrome, Cardiology and Cardiovascular Medicine, Prasugrel Hydrochloride, Platelet Aggregation Inhibitors
Abstract

Aims To establish the safety and efficacy of different dual antiplatelet therapy (DAPT) combinations in patients with acute coronary syndrome (ACS) according to their baseline ischaemic and bleeding risk estimated with a machine learning derived model [machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE) score]. Methods and results Incidences of death, re-acute myocardial infarction (re-AMI), and Bleeding Academic Research Consortium 3–5 bleeding with aspirin plus different P2Y12 inhibitors (clopidogrel or potent P2Y12 inhibitors: ticagrelor or prasugrel) were appraised among patients of the PRAISE data set grouped in four subcohorts: low-to-moderate ischaemic and bleeding risk; low-to-moderate ischaemic risk and high bleeding risk; high ischaemic risk and low-to-moderate bleeding risk; and high ischaemic and bleeding risk. Hazard ratios (HRs) for the outcome measures were derived with inverse probability of treatment weighting adjustment. Among patients with low-to-moderate bleeding risk, clopidogrel was associated with higher rates of re-AMI in those at low-to-moderate ischaemic risk [HR 1.69, 95% confidence interval (CI) 1.16–2.51; P = 0.006] and increased risk of death (HR 3.2, 1.45–4.21; P = 0.003) and re-AMI (HR 2.23, 1.45–3.41; P < 0.001) in those at high ischaemic risk compared with prasugrel or ticagrelor, without a difference in the risk of major bleeding. Among patients with high bleeding risk, clopidogrel showed comparable risk of death, re-AMI, and major bleeding vs. potent P2Y12 inhibitors, regardless of the baseline ischaemic risk. Conclusion Among ACS patients with non-high risk of bleeding, the use of potent P2Y12 inhibitors is associated with a lower risk of death and recurrent ischaemic events, without bleeding excess. Patients deemed at high bleeding risk may instead be safely addressed to a less intensive DAPT strategy with clopidogrel.

Published
2022

26. 763 Feasibility and reliability of a comprehensive three-dimensional transesophageal echocardiography screening process for transcatheter mitral valve replacement

Author

Piroli, Francesco, primary, Boccellino, Antonio, additional, Ingallina, Giacomo, additional, Rolando, Marco, additional, Melillo, Francesco, additional, Ancona, Francesco, additional, Stella, Stefano, additional, Biondi, Federico, additional, Denti, Paolo, additional, Castiglioni, Alessandro, additional, and Agricola, Eustachio, additional

Published
2021
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27. Impacto de los tratamientos hipolipemiantes en los resultados cardiovasculares según la puntuación de calcio coronario. Revisión sistemática y metanálisis

Author

Gallone, Guglielmo, primary, Elia, Edoardo, additional, Bruno, Francesco, additional, Angelini, Filippo, additional, Franchin, Luca, additional, Bocchino, Pier Paolo, additional, Piroli, Francesco, additional, Annone, Umberto, additional, Montabone, Andrea, additional, Marengo, Giorgio, additional, Bertaina, Maurizio, additional, De Filippo, Ovidio, additional, Baldetti, Luca, additional, Palmisano, Anna, additional, Serafini, Alessandro, additional, Esposito, Antonio, additional, Depaoli, Alessandro, additional, D’ascenzo, Fabrizio, additional, Fonio, Paolo, additional, and De Ferrari, Gaetano Maria, additional

Published
2021
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28. Impact of lipid-lowering therapies on cardiovascular outcomes according to coronary artery calcium score. A systematic review and meta-analysis

Author

Gallone, Guglielmo, primary, Elia, Edoardo, additional, Bruno, Francesco, additional, Angelini, Filippo, additional, Franchin, Luca, additional, Bocchino, Pier Paolo, additional, Piroli, Francesco, additional, Annone, Umberto, additional, Montabone, Andrea, additional, Marengo, Giorgio, additional, Bertaina, Maurizio, additional, De Filippo, Ovidio, additional, Baldetti, Luca, additional, Palmisano, Anna, additional, Serafini, Alessandro, additional, Esposito, Antonio, additional, Depaoli, Alessandro, additional, D’ascenzo, Fabrizio, additional, Fonio, Paolo, additional, and De Ferrari, Gaetano Maria, additional

Published
2021
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29. Percutaneous coronary intervention versus coronary artery surgery for left main disease according to lesion site: A meta-analysis

Author

De Filippo, Ovidio, primary, Di Franco, Antonino, additional, Boretto, Paolo, additional, Bruno, Francesco, additional, Cusenza, Vincenzo, additional, Desalvo, Paolo, additional, Demetres, Michelle, additional, Saglietto, Andrea, additional, Franchin, Luca, additional, Piroli, Francesco, additional, Marengo, Giorgio, additional, Elia, Edoardo, additional, Falk, Volkmar, additional, Conrotto, Federico, additional, Doenst, Torsten, additional, Rinaldi, Mauro, additional, De Ferrari, Gaetano Maria, additional, D'Ascenzo, Fabrizio, additional, and Gaudino, Mario, additional

Published
2021
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30. De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a network meta-analysis of randomised controlled trials

Author

De Filippo, Ovidio, additional, Piroli, Francesco, additional, Bruno, Francesco, additional, Bocchino, Pier Paolo, additional, Saglietto, Andrea, additional, Franchin, Luca, additional, Angelini, Filippo, additional, Gallone, Guglielmo, additional, Alabed, Samer, additional, Gasparini, Mauro, additional, Ahmad, Mahmood, additional, De Ferrari, Gaetano Maria, additional, and D'Ascenzo, Fabrizio, additional

Published
2021
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31. Anti-interleukin 1 agents for the treatment of recurrent pericarditis: a systematic review and meta-analysis

Author

Imazio, Massimo Andreis, Alessandro Piroli, Francesco and Lazaros, George Gattorno, Marco Lewinter, Martin Klein, Allan L. Brucato, Antonio

Abstract

Aims Corticosteroid-dependent and colchicine-resistant recurrent pericarditis (RP) is a challenging management problem, in which conventional anti-inflammatory therapy (nonsteroidal anti-inflammatory drugs, colchicine, corticosteroids) is unable to control the disease. Recent data suggest a potential role for anti-interleukin-1 (IL-1) agents for this condition. This study was designed to assess the safety and efficacy of anti-IL-1 agents in this setting. Methods We performed a systematic review and meta-analysis of randomised controlled trials and observational studies assessing pericarditis recurrences and drug-related adverse events in patients receiving anti-IL-1 drugs for pericarditis. Results The meta-analysis assessed 7 studies including 397 pooled patients with RP. The median age was 42 years, 60% were women and the aetiology was idiopathic in 87%. After a median follow-up of 14 months (IQR,12-39), patients receiving anti-IL-1 agents (anakinra or rilonacept) had a significantly reduction in pericarditis recurrences (incidence rate ratio 0.06, 95% CI 0.03 to 0.14), compared with placebo and/or standard medical therapy. Anti-IL-1 agents were associated with increased risk of adverse events compared with placebo (risk ratio (RR) 5.38, 95% CI 2.08 to 13.92): injection-site reactions occurred in 15/41 (36.6%) vs none (RR 14.98, 95% CI 2.09 to 107.09), infections occurred in 13/51 (25.5%) vs 3/41 (7.3%; RR 3.65, 95% CI 1.23 to 10.85). Anti-IL-1 agents were not associated with increased risk of severe adverse events. Conclusions In patients with RP, anti-IL-1 agents (anakinra and rilonacept) are efficacious for prevention of recurrences, without severe adverse events.

Published
2021

32. Impact of lipid-lowering therapies on cardiovascular outcomes according to coronary artery calcium score. A systematic review and meta-analysis.

Author

Gallone, Guglielmo, Elia, Edoardo, Bruno, Francesco, Angelini, Filippo, Franchin, Luca, Bocchino, Pier Paolo, Piroli, Francesco, Annone, Umberto, Montabone, Andrea, Marengo, Giorgio, Bertaina, Maurizio, De Filippo, Ovidio, Baldetti, Luca, Palmisano, Anna, Serafini, Alessandro, Esposito, Antonio, Depaoli, Alessandro, D'ascenzo, Fabrizio, Fonio, Paolo, and De Ferrari, Gaetano Maria

Abstract

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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36. Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets

Author

D'Ascenzo, Fabrizio, primary, De Filippo, Ovidio, additional, Gallone, Guglielmo, additional, Mittone, Gianluca, additional, Deriu, Marco Agostino, additional, Iannaccone, Mario, additional, Ariza-Solé, Albert, additional, Liebetrau, Christoph, additional, Manzano-Fernández, Sergio, additional, Quadri, Giorgio, additional, Kinnaird, Tim, additional, Campo, Gianluca, additional, Simao Henriques, Jose Paulo, additional, Hughes, James M, additional, Dominguez-Rodriguez, Alberto, additional, Aldinucci, Marco, additional, Morbiducci, Umberto, additional, Patti, Giuseppe, additional, Raposeiras-Roubin, Sergio, additional, Abu-Assi, Emad, additional, De Ferrari, Gaetano Maria, additional, Piroli, Francesco, additional, Saglietto, Andrea, additional, Conrotto, Federico, additional, Omedé, Pierluigi, additional, Montefusco, Antonio, additional, Pennone, Mauro, additional, Bruno, Francesco, additional, Bocchino, Pier Paolo, additional, Boccuzzi, Giacomo, additional, Cerrato, Enrico, additional, Varbella, Ferdinando, additional, Sperti, Michela, additional, Wilton, Stephen B., additional, Velicki, Lazar, additional, Xanthopoulou, Ioanna, additional, Cequier, Angel, additional, Iniguez-Romo, Andres, additional, Munoz Pousa, Isabel, additional, Cespon Fernandez, Maria, additional, Caneiro Queija, Berenice, additional, Cobas-Paz, Rafael, additional, Lopez-Cuenca, Angel, additional, Garay, Alberto, additional, Blanco, Pedro Flores, additional, Rognoni, Andrea, additional, Biondi Zoccai, Giuseppe, additional, Biscaglia, Simone, additional, Nunez-Gil, Ivan, additional, Fujii, Toshiharu, additional, Durante, Alessandro, additional, Song, Xiantao, additional, Kawaji, Tetsuma, additional, Alexopoulos, Dimitrios, additional, Huczek, Zenon, additional, Gonzalez Juanatey, Jose Ramon, additional, Nie, Shao-Ping, additional, Kawashiri, Masa-aki, additional, Colonnelli, Iacopo, additional, Cantalupo, Barbara, additional, Esposito, Roberto, additional, Leonardi, Sergio, additional, Grosso Marra, Walter, additional, Chieffo, Alaide, additional, Michelucci, Umberto, additional, Piga, Dario, additional, Malavolta, Marta, additional, Gili, Sebastiano, additional, Mennuni, Marco, additional, Montalto, Claudio, additional, Oltrona Visconti, Luigi, additional, and Arfat, Yasir, additional

Published
2021
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37. Fractional flow reserve guided versus angiographic guided surgical revascularization: A meta‐analysis

Author

Bruno, Francesco, primary, D'Ascenzo, Fabrizio, additional, Marengo, Giorgio, additional, Manfredi, Roberto, additional, Saglietto, Andrea, additional, Gallone, Guglielmo, additional, Franchin, Luca, additional, Piroli, Francesco, additional, Angelini, Filippo, additional, De Filippo, Ovidio, additional, Conrotto, Federico, additional, Omedè, Pierluigi, additional, Montefusco, Antonio, additional, Pennone, Mauro, additional, Boffini, Massimo, additional, Pocar, Marco, additional, Rinaldi, Mauro, additional, and De Ferrari, Gaetano Maria, additional

Published
2020
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40. Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study

Author

Franchin, Luca, primary, Piroli, Francesco, additional, D’Ascenzo, Fabrizio, additional, Nuñez-Gil, Ivan, additional, Wojakowski, Wojciech, additional, Imori, Yoichi, additional, Trabattoni, Daniela, additional, Huczek, Zenon, additional, Venuti, Giuseppe, additional, Muscoli, Saverio, additional, Montabone, Andrea, additional, Rognoni, Andrea, additional, Parma, Radoslaw, additional, Figini, Filippo, additional, Mitomo, Satoru, additional, Quadri, Giorgio, additional, Wańha, Wojciech, additional, Cortese, Bernardo, additional, De Filippo, Ovidio, additional, Ryan, Nicola, additional, Varbella, Ferdinando, additional, Sheiban, Imad, additional, Helft, Gerard, additional, and De Ferrari, Gaetano M., additional

Published
2020
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41. Percutaneous coronary intervention of unprotected left main and bifurcation in octogenarians: Subanalysis from RAIN (veRy thin stents for patients with left mAIn or bifurcatioN in real life)

Author

Conrotto, Federico, primary, D'Ascenzo, Fabrizio, additional, Piroli, Francesco, additional, Franzé, Alfonso, additional, Luca, Leonardo, additional, Quadri, Giorgio, additional, Ryan, Nicola, additional, Escaned, Javier, additional, Bo, Mario, additional, and De Ferrari, Gaetano Maria, additional

Published
2020
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42. Accuracy of the PARIS score and PCI complexity to predict ischemic events in patients treated with very thin stents in unprotected left main or coronary bifurcations

Author

Gallone, Guglielmo, primary, D'Ascenzo, Fabrizio, additional, Conrotto, Federico, additional, Costa, Francesco, additional, Capodanno, Davide, additional, Muscoli, Saverio, additional, Chieffo, Alaide, additional, Yoichi, Imori, additional, Pennacchi, Mauro, additional, Quadri, Giorgio, additional, Nuñez‐Gil, Ivan, additional, Bocchino, Pier Paolo, additional, Piroli, Francesco, additional, De Filippo, Ovidio, additional, Rolfo, Cristina, additional, Wojakowski, Wojciech, additional, Trabattoni, Daniela, additional, Huczek, Zenon, additional, Venuti, Giuseppe, additional, Montabone, Andrea, additional, Rognoni, Andrea, additional, Parma, Radoslaw, additional, Figini, Filippo, additional, Mitomo, Satoru, additional, Boccuzzi, Giacomo, additional, Mattesini, Alessio, additional, Cerrato, Enrico, additional, Wańha, Wojciech, additional, Smolka, Grzegorz, additional, Cortese, Bernardo, additional, Ryan, Nicola, additional, Bo, Mario, additional, Mario, Carlo, additional, Varbella, Ferdinando, additional, Burzotta, Francesco, additional, Sheiban, Imad, additional, Escaned, Javier, additional, Helft, Gerard, additional, and De Ferrari, Gaetano Maria, additional

Published
2020
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43. Fractional flow reserve guided versus angiographic guided surgical revascularization: A meta-analysis.

Author

Bruno, Francesco, D'Ascenzo, Fabrizio, Marengo, Giorgio, Manfredi, Roberto, Saglietto, Andrea, Gallone, Guglielmo, Franchin, Luca, Piroli, Francesco, Angelini, Filippo, De Filippo, Ovidio, Conrotto, Federico, Omedè, Pierluigi, Montefusco, Antonio, Pennone, Mauro, Boffini, Massimo, Pocar, Marco, Rinaldi, Mauro, and Maria De Ferrari, Gaetano

Published
2021
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46. Accuracy of the PARIS score and PCI complexity to predict ischemic events in patients treated with very thin stents in unprotected left main or coronary bifurcations.

Author

Gallone, Guglielmo, D'Ascenzo, Fabrizio, Conrotto, Federico, Costa, Francesco, Capodanno, Davide, Muscoli, Saverio, Chieffo, Alaide, Yoichi, Imori, Pennacchi, Mauro, Quadri, Giorgio, Nuñez‐Gil, Ivan, Bocchino, Pier Paolo, Piroli, Francesco, De Filippo, Ovidio, Rolfo, Cristina, Wojakowski, Wojciech, Trabattoni, Daniela, Huczek, Zenon, Venuti, Giuseppe, and Montabone, Andrea

Published
2021
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47. Stroke volume index and transvalvular flow rate trajectories in severe aortic stenosis treated with TAVR.

Author

Gallone G, Islas F, Gorla R, Melillo F, Leone PP, Cimaglia P, Pastore MC, Franzone A, Landra F, Bruno F, Scudeler L, Jimenez-Quevedo P, Viva T, Piroli F, Bragato R, Trichilo M, Degiovanni A, Ilardi F, Andreis A, Nombela-Franco L, Maurizio T, Toselli M, Conrotto F, Montorfano M, Manzo R, Cameli M, Patti G, Stefanini G, Testa L, Giannini F, Agricola E, Escaned J, D'Ascenzo F, and De Ferrari GM

Subjects
Humans, Stroke Volume, Treatment Outcome, Risk Factors, Retrospective Studies, Aortic Valve diagnostic imaging, Aortic Valve surgery, Severity of Illness Index, Transcatheter Aortic Valve Replacement methods, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery
Abstract

Aims: The prognostic impact of flow trajectories according to stroke volume index (SVi) and transvalvular flow rate (FR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) remains poorly assessed. We evaluated and compared SVi and FR prior and after TAVR for severe AS., Methods and Results: Patients were categorized according to SVi (<35 mL/m2) and FR (<200 mL/s). The association of pre- and post-TAVR SVi and FR with all-cause mortality up to 3 years was assessed with multivariable Cox regression models. Among 980 patients with pre-TAVR flow assessment, SVi was reduced in 41.3% and FR in 48.1%. Baseline flow status was not an independent mortality predictor [SVi: hazard ratio (HR) 1.22, 95% confidence interval (CI) 0.85-1.82, FR: HR 0.78, 95% CI 0.48-1.27]. Among 731 patients undergoing early (5 days, interquartile range 2-29) post-TAVR flow assessment, SVi recovered in 40.1% and FR in 49.0% patients with baseline low flow. Reduced FR following TAVR was an independent predictor of mortality (HR 1.67, 95% CI 1.02-2.74), whereas SVi was not (HR 0.97, 95% CI 0.53-1.78). Three-year estimated mortality in patients with recovered FR was lower than that in patients with reduced FR (13.3 vs. 37.7% vs, P = 0.003) and similar to that in patients with normal baseline FR (P = 0.317)., Conclusion: Baseline flow status was not an independent predictor of mid-term mortality among all-comers with severe AS undergoing TAVR. Flow recovery early after TAVR was frequent. Post-TAVR FR, but not SVi, was independently associated with mid-term all-cause mortality. By impacting flow status, AV replacement modifies the association of flow status with outcomes., Competing Interests: Conflict of interest: M.M. received consultant fees from Abbott, Boston Scientific, Kardia, and Medtronic. The other authors have no conflicts of interest to declare., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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48. Feasibility and reliability of comprehensive three-dimensional transoesophageal echocardiography screening process for transcatheter mitral valve replacement.

Author

Piroli F, Boccellino A, Ingallina G, Rolando M, Melillo F, Ancona F, Stella S, Biondi F, Palmisano A, Esposito A, Denti P, Montorfano M, Maisano F, Castiglioni A, and Agricola E

Subjects
Humans, Mitral Valve diagnostic imaging, Echocardiography, Transesophageal, Reproducibility of Results, Feasibility Studies, Treatment Outcome, Cardiac Catheterization methods, Heart Valve Prosthesis Implantation methods, Heart Valve Prosthesis, Ventricular Outflow Obstruction, Leukemia, Myeloid, Acute, Mitral Valve Insufficiency surgery
Abstract

Aims: The procedural planning of transcatheter mitral valve replacement (TMVR) requires a specific imaging assessment to establish patient eligibility. Computed tomography (CT) is considered the reference method. In this setting, data regarding the role of transoesophageal echocardiography (TOE) are lacking. We evaluated the feasibility and reliability of a comprehensive 3D-TOE screening in TMVR candidates., Methods and Results: We performed a retrospective observational study including 72 consecutive patients who underwent a pre-procedural CT and 3D-TOE for TMVR evaluation. The measurements of mitral annulus (MA), length of anterior mitral leaflet (AML), native left ventricular outflow tract (LVOT), and predicted neo-LVOT acquired with CT and 3D-TOE were compared using a novel semi-automated software for post processing analysis (3 mensio Structural Heart 10.1-3mSH, Pie Medical Imaging, Bilthoven, Netherlands). The final suitability decision was given by the valve manufacturer based on CT measurements and clinical conditions. Among 72 patients screened, all patients had adequate image quality for 3D-TOE analysis. 3D-TOE and CT measurements for AML length (r = 0.97), MA area (r = 0.90), perimeter (r = 0.68), anteroposterior (r = 0.88), and posteromedial-anterolateral (r = 0.74) diameters were found highly correlated, as well as for native LVOT (r = 0.86) and predicted neo-LVOT areas (r = 0.96) (all P-values <0.0001). An almost perfect agreement between CT and 3DTOE was found in assessing the eligibility for TMVR implantation (Cohen kappa 0.83, P < 0.001)., Conclusion: 3D-TOE appraisements showed good correlations with CT measurements and high accuracy to predict TMVR screening success., Competing Interests: Conflicts of interest: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2023
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49. Three-Dimensional Finger Test: A New Echocardiographic Method to Locate the Best Access Site During NeoChord Procedure.

Author

Vairo A, Manai R, Gaiero L, Desalvo P, Bellettini M, Zaccaro L, Rinaudo A, Franchin L, Piroli F, Bruno F, Sebastiano V, Cura Stura E, Barbero C, Marro M, Faletti R, Alunni G, De Ferrari GM, Rinaldi M, and Salizzoni S

Subjects
Humans, Echocardiography, Echocardiography, Transesophageal methods, Mitral Valve Insufficiency surgery, Mitral Valve Prolapse surgery, Echocardiography, Three-Dimensional methods
Abstract

Objective: Transventricular beating-heart mitral valve repair (TBMVR) with artificial chordae implantation is a technique to treat mitral valve prolapse. Two-dimensional (2D) echocardiography completed with simultaneous biplane view during surgeon finger pushing on the left ventricular (LV) wall (finger test [FT]) is currently used to localize the desired LV access, on the inferior-lateral wall, between the papillary muscles (PMs). We aimed to compare a new three-dimensional (3D) method with conventional FT in terms of safety and better localization of LV access., Methods: During TBMVR, conventional FT was completed using 3D transesophageal echocardiography by placing the sample box in the bicommissural view of the LV, including the PMs and the apex. The 3D volume was subsequently edited to visualize the LV from above (surgical view) to localize the bulge of the operator's finger pushing on the LV. We asked the first operator, the second operator, and the cardiac surgery fellow, separately, to evaluate the location of their finger pushing, both with the 2D method and the 3D method, to estimate the interoperator concordance., Results: From 2019 to 2021, 42 TBMVRs were performed without complications related to access using FT completed with the 3D method. Regarding the choice of the right and safe entry site, the operator's agreement was higher using 3D rendering compared with conventional FT (mean agreement 0.59 ± 0.29 for 2D vs 0.83 ± 0.20 for 3D), while full operator agreement was 10 of 42 for 2D and 23 of 42 for 3D ( P = 0.004)., Conclusions: Three-dimensional FT is easy to perform and facilitates surgeons choosing the best access for TBMVR in term of anatomical localization and safety.

Published
2023
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50. Safety and efficacy of different P2Y12 inhibitors in patients with acute coronary syndromes stratified by the PRAISE risk score: a multicentre study.

Author

Patti G, D'Ascenzo F, De Filippo O, Bruno F, Leonardi S, Chieffo A, Iannaccone M, Liebetrau C, Manzano-Fernández S, Gallone G, Omedè P, Cerrato E, Kinnaird T, Conrotto F, Piroli F, Henriques JPS, Wańha W, Elia E, Dominguez-Rodriguez A, Raposeiras-Roubin S, Abu-Assi E, and De Ferrari GM

Subjects
Humans, Ticagrelor therapeutic use, Clopidogrel therapeutic use, Prasugrel Hydrochloride adverse effects, Purinergic P2Y Receptor Antagonists adverse effects, Platelet Aggregation Inhibitors adverse effects, Treatment Outcome, Hemorrhage chemically induced, Hemorrhage epidemiology, Risk Factors, Acute Coronary Syndrome drug therapy, Myocardial Infarction epidemiology
Abstract

Aims: To establish the safety and efficacy of different dual antiplatelet therapy (DAPT) combinations in patients with acute coronary syndrome (ACS) according to their baseline ischaemic and bleeding risk estimated with a machine learning derived model [machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE) score]., Methods and Results: Incidences of death, re-acute myocardial infarction (re-AMI), and Bleeding Academic Research Consortium 3-5 bleeding with aspirin plus different P2Y12 inhibitors (clopidogrel or potent P2Y12 inhibitors: ticagrelor or prasugrel) were appraised among patients of the PRAISE data set grouped in four subcohorts: low-to-moderate ischaemic and bleeding risk; low-to-moderate ischaemic risk and high bleeding risk; high ischaemic risk and low-to-moderate bleeding risk; and high ischaemic and bleeding risk. Hazard ratios (HRs) for the outcome measures were derived with inverse probability of treatment weighting adjustment. Among patients with low-to-moderate bleeding risk, clopidogrel was associated with higher rates of re-AMI in those at low-to-moderate ischaemic risk [HR 1.69, 95% confidence interval (CI) 1.16-2.51; P = 0.006] and increased risk of death (HR 3.2, 1.45-4.21; P = 0.003) and re-AMI (HR 2.23, 1.45-3.41; P < 0.001) in those at high ischaemic risk compared with prasugrel or ticagrelor, without a difference in the risk of major bleeding. Among patients with high bleeding risk, clopidogrel showed comparable risk of death, re-AMI, and major bleeding vs. potent P2Y12 inhibitors, regardless of the baseline ischaemic risk., Conclusion: Among ACS patients with non-high risk of bleeding, the use of potent P2Y12 inhibitors is associated with a lower risk of death and recurrent ischaemic events, without bleeding excess. Patients deemed at high bleeding risk may instead be safely addressed to a less intensive DAPT strategy with clopidogrel., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2022
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