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2. Electrogram Fractionation-Guided Ablation in the Left Atrium Decreases the Frequency of Activation in the Pulmonary Veins and Leads to Atrial Fibrillation Termination: Pulmonary Vein Modulation Rather Than Isolation

Author

Seitz, Julien, Bars, Clement, Ferracci, Ange, Maluski, Alexandre, Penaranda, Guillaume, Theodore, Guillaume, Faure, Jacques, Bremondy, Michel, Curel, Laurence, Beurtheret, Sylvain, Avula, Uma M.R., Kalifa, Jerome, and Pisapia, Andre

Published
2016
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3. Artificial intelligence software standardizes electrogram‐based ablation outcome for persistent atrial fibrillation

Author

Seitz, Julien, primary, Durdez, Théophile Mohr, additional, Albenque, Jean P., additional, Pisapia, André, additional, Gitenay, Edouard, additional, Durand, Cyril, additional, Monteau, Jacques, additional, Moubarak, Ghassan, additional, Théodore, Guillaume, additional, Lepillier, Antoine, additional, Zhao, Alexandre, additional, Bremondy, Michel, additional, Maluski, Alexandre, additional, Cauchemez, Bruno, additional, Combes, Stéphane, additional, Guyomar, Yves, additional, Heuls, Sébastien, additional, Thomas, Olivier, additional, Penaranda, Guillaume, additional, Siame, Sabrina, additional, Appetiti, Anthony, additional, Milpied, Paola, additional, Bars, Clément, additional, and Kalifa, Jérôme, additional

Published
2022
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4. Guidelines issued by the French Society of Cardiology concerning the competence, performance and environment required in the practice of diagnostic and interventional cardiac electrophysiology

Author

Piot, Olivier, Anselme, Frédéric, Bovéda, Serge, Chauvin, Michel, Daubert, Jean-Claude, Defaye, Pascal, Deharo, Jean-Claude, Gras, Daniel, Hermida, Jean-Sylvain, Kacet, Salem, Klug, Didier, Leenhardt, Antoine, le Heuzey, Jean-Yves, Mabo, Philippe, Pisapia, André, Sadoul, Nicolas, Salvador-Mazenq, Michèle, and Cazeau, Serge

Published
2011
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6. Worldwide Experience with the Robotic Navigation System in Catheter Ablation of Atrial Fibrillation: Methodology, Efficacy and Safety

Author

BAI, RONG, DI BIASE, LUIGI, VALDERRABANO, MIGUEL, LORGAT, FAIZEL, MLCOCHOVA, HANKA, TILZ, ROLAND, MEYERFELDT, UDO, HRANITZKY, PATRICK M., WAZNI, OUSSAMA, KANAGARATNAM, PRAPA, DOSHI, RAHUL N., GIBSON, DOUGLAS, PISAPIA, ANDRÉ, MOHANTY, PRASANT, SALIBA, WALID, OUYANG, FEIFAN, KAUTZNER, JOSEF, GALLINGHOUSE, JOSEPH G., and NATALE, ANDREA

Published
2012
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8. AF Ablation Guided by Spatiotemporal Electrogram Dispersion Without Pulmonary Vein Isolation: A Wholly Patient-Tailored Approach

Author

Seitz, Julien, Bars, Clément, Théodore, Guillaume, Beurtheret, Sylvain, Lellouche, Nicolas, Bremondy, Michel, Ferracci, Ange, Faure, Jacques, Penaranda, Guillaume, Yamazaki, Masatoshi, Avula, Uma Mahesh R., Curel, Laurence, Siame, Sabrina, Berenfeld, Omer, Pisapia, André, and Kalifa, Jérôme

Subjects
Ablation Techniques, Male, Middle Aged, Article, Electrocardiography, Pulmonary Veins, Recurrence, Atrial Fibrillation, Catheter Ablation, Humans, Female, Prospective Studies, Electrophysiologic Techniques, Cardiac, Follow-Up Studies
Abstract

The use of intracardiac electrograms to guide atrial fibrillation (AF) ablation has yielded conflicting results.The authors evaluated the usefulness of spatiotemporal dispersion, a visually recognizable electric footprint of AF drivers, for the ablation of all forms of AF.The authors prospectively enrolled 105 patients admitted for AF ablation. AF was sequentially mapped in both atria with a 20-pole PentaRay catheter. The authors tagged and ablated only regions displaying electrogram dispersion during AF. Results were compared to a validation set in which a conventional ablation approach was used (pulmonary vein isolation/stepwise approach). To establish the mechanism underlying spatiotemporal dispersion of AF electrograms, the authors conducted realistic numerical simulations of AF drivers in a 2-dimensional model and optical mapping of ovine atrial scar-related AF.Ablation at dispersion areas terminated AF in 95% of the 105 patients. After ablation of 17 ± 10% of the left atrial surface and 18 months of follow-up, the atrial arrhythmia recurrence rate was 15% after 1.4 ± 0.5 procedures per patient versus 41% in the validation set after 1.5 ± 0.5 procedures per patient (arrhythmia free-survival: 85% vs. 59%; log-rank p 0.001). Compared with the validation set, radiofrequency times (49 ± 21 min vs. 85 ± 34.5 min; p = 0.001) and procedure times (168 ± 42 min vs. 230 ± 67 min; p 0.0001) were shorter. In simulations and optical mapping experiments, virtual PentaRay recordings demonstrated that electrogram dispersion is mostly recorded in the vicinity of a driver.The clustering of intracardiac electrograms exhibiting spatiotemporal dispersion is indicative of AF drivers. Their ablation allows for a nonextensive and patient-tailored approach to AF ablation. (Substrate Ablation Guided by High Density Mapping in Atrial Fibrillation [SUBSTRATE HD]; NCT02093949).

Published
2016

9. Reply

Author

Seitz, Julien, primary, Bars, Clément, additional, Beurtheret, Sylvain, additional, Penaranda, Guillaume, additional, Pisapia, André, additional, and Kalifa, Jérôme, additional

Published
2017
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10. AF Ablation Guided by Spatiotemporal Electrogram Dispersion Without Pulmonary Vein Isolation

Author

Seitz, Julien, primary, Bars, Clément, additional, Théodore, Guillaume, additional, Beurtheret, Sylvain, additional, Lellouche, Nicolas, additional, Bremondy, Michel, additional, Ferracci, Ange, additional, Faure, Jacques, additional, Penaranda, Guillaume, additional, Yamazaki, Masatoshi, additional, Avula, Uma Mahesh R., additional, Curel, Laurence, additional, Siame, Sabrina, additional, Berenfeld, Omer, additional, Pisapia, André, additional, and Kalifa, Jérôme, additional

Published
2017
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11. Abstract 10865: Online Multielectrode Catheter-enabled Temporal Tctivation Electrogram Enalysis for Localization of Atrial Fibrillation Rotor Regions: Substrate HD Study

Author

Bars, Clément, primary, Seitz, Julien, additional, Theodore, Guillaume, additional, Beurtheret, Sylvain, additional, Marijon, Eloi, additional, Ferracci, Ange, additional, Bremondy, Michel, additional, Faure, Jacques, additional, Curel, Laurence, additional, Penaranda, Guillaume, additional, Berenfeld, Omer, additional, Kalifa, Jérôme, additional, and Pisapia, André, additional

Published
2015
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12. Active or passive pulmonary vein in atrial fibrillation: Is pulmonary vein isolation always essential?

Author

Seitz, Julien, primary, Horvilleur, Jérôme, additional, Curel, Laurence, additional, Lacotte, Jérôme, additional, Maluski, Alexandre, additional, Ferracci, Ange, additional, Bremondy, Michel, additional, Rosier, Arnaud, additional, Monchi, Mehran, additional, Penaranda, Guillaume, additional, Faure, Jacques, additional, Beurtheret, Sylvain, additional, and Pisapia, André, additional

Published
2014
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14. Sino-Atrial Dissociation: Evidence by Intracardiac Recordings in Man and by Microelectrode Studies on Isolated Rabbit Atrium.

Author

Pisapia, André, Leheuzey, Jean Yves, Faure, Jacques, Simonetti, Bernard, Szatmary, Laszlo, Carta, Mireille, Rosario, Roger, Barnay, Claude, and Duport, Guy

Subjects
SINOATRIAL node, ELECTROPHYSIOLOGY, ELECTROCARDIOGRAPHY, ELECTRODIAGNOSIS, HEART atrium, LABORATORY rabbits
Abstract

The electrophysiologic mechanisms of sinus dysfunction have recently been determined by direct recording of the sinus node electrogram. The association of various degrees of abnormalities in the formation of the impulse within the sinus node and of sinoatrial conduction block, represents the pathophysiological substrate of the mechanism of sinus node dysfunction. The purpose of this work is to present clinical and experimental data supporting the concept of sinus node isolation. In our clinical case, the sinus node was probably intact despite aspects of sinus node dysfunction on the surface ECG. Sinus node electrograms were recorded with a sinoatrial conduction time of 100 ms (normal values in our laboratory: 83 ms ± 38 ms). Atrial mapping demonstrated that the area depolarized by the sinus node involved a 2 cm² zone surrounding it. This perisinusal activity could not be recorded on the surface ECG. Both exit and entry blocks in the sinus node were demonstrated. Our experimental data showed o total desynchronization between the electrical activity of the sinus node and that of the atrium under hypoxic conditions. Both types of cases demonstrated that an atrial dysrhythmia was coexisting with regular sinus activity. From these data we concluded that a sinus node free from any pathological involvement could be associated with severe symptoms of sinus node dysfunction on the surface ECG. [ABSTRACT FROM AUTHOR]

Published
1988
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15. Clinical Use of a New Myocardial Electrode.

Author

Jausseran, Jean-Michel, Timpone, Gérard, Formichi, Maxime, and Pisapia, André

Subjects
ELECTRONICS in cardiology, MEDICAL equipment, SURGICAL complications, OPERATIVE surgery, CARDIAC surgery, CARDIOLOGY
Abstract

Prior to clinical use, this new myocardial stimulating electrode was studied in animals in order to test its electrical and mechanical reliability. The Telectronics 030.168 electrode consists of a conductor constructed of 3 stainless steel wires. Its present surface area is 25 mm² and its length is 10 mm. The device is easily inserted into the myocardium with a suture and needle and is held in place with a surgical clip, We report observations on 42 patients made over an average follow-up period of 14.6 months. There were no surgical complications and there was no operative mortality. Calculated as an average of recorded electrical measurements, the stimulating threshold was 1.03 volts and 2.40 mA at 500 ms. None of the patients have required further surgery and no malfunctions have been discovered. [ABSTRACT FROM AUTHOR]

Published
1982
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