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191 results on '"Piskol, Robert"'

1. NKG2D-bispecific enhances NK and CD8+ T cell antitumor immunity

Author

Herault, Aurelie, Mak, Judy, de la Cruz-Chuh, Josefa, Dillon, Michael A., Ellerman, Diego, Go, MaryAnn, Cosino, Ely, Clark, Robyn, Carson, Emily, Yeung, Stacey, Pichery, Melanie, Gador, Mylène, Chiang, Eugene Y., Wu, Jia, Liang, Yuxin, Modrusan, Zora, Gampa, Gautham, Sudhamsu, Jawahar, Kemball, Christopher C., Cheung, Victoria, Nguyen, Thi Thu Thao, Seshasayee, Dhaya, Piskol, Robert, Totpal, Klara, Yu, Shang-Fan, Lee, Genee, Kozak, Katherine R., Spiess, Christoph, and Walsh, Kevin B.

Published
2024
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4. Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

Author

Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, and de Sauvage, Frederic J.

Published
2023
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7. ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma

Author

Yen, Ivana, Shanahan, Frances, Lee, Jeeyun, Hong, Yong Sang, Shin, Sang Joon, Moore, Amanda R., Sudhamsu, Jawahar, Chang, Matthew T., Bae, Inhwan, Dela Cruz, Darlene, Hunsaker, Thomas, Klijn, Christiaan, Liau, Nicholas P.D., Lin, Eva, Martin, Scott E., Mondrusan, Zora, and Piskol, Robert

Subjects
Antineoplastic agents -- Dosage and administration, Mutation (Biology) -- Health aspects, Protein kinases -- Physiological aspects, Melanoma -- Genetic aspects -- Drug therapy, Antimitotic agents -- Dosage and administration, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAF.sup.V600-mutant melanoma, they are ineffective in non-BRAF.sup.V600 mutant cells.sup.1-3. Belvarafenib is a potent and selective RAF dimer (type II) inhibitor that exhibits clinical activity in patients with BRAF.sup.V600E- and NRAS-mutant melanomas. Here we report the first-in-human phase I study investigating the maximum tolerated dose, and assessing the safety and preliminary efficacy of belvarafenib in BRAF.sup.V600E- and RAS-mutated advanced solid tumours (NCT02405065, NCT03118817). By generating belvarafenib-resistant NRAS-mutant melanoma cells and analysing circulating tumour DNA from patients treated with belvarafenib, we identified new recurrent mutations in ARAF within the kinase domain. ARAF mutants conferred resistance to belvarafenib in both a dimer- and a kinase activity-dependent manner. Belvarafenib induced ARAF mutant dimers, and dimers containing mutant ARAF were active in the presence of inhibitor. ARAF mutations may serve as a general resistance mechanism for RAF dimer inhibitors as the mutants exhibit reduced sensitivity to a panel of type II RAF inhibitors. The combination of RAF plus MEK inhibition may be used to delay ARAF-driven resistance and suggests a rational combination for clinical use. Together, our findings reveal specific and compensatory functions for the ARAF isoform and implicate ARAF mutations as a driver of resistance to RAF dimer inhibitors. The development, characterization and phase I clinical testing of the RAF inhibitor belvarafenib in cancer and a new resistance mechanism mediated by ARAF mutations are described., Author(s): Ivana Yen [sup.1] , Frances Shanahan [sup.1] , Jeeyun Lee [sup.2] [sup.3] , Yong Sang Hong [sup.4] , Sang Joon Shin [sup.5] , Amanda R. Moore [sup.1] , Jawahar [...]

Published
2021
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11. Table S7 from Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways

Author

Pham, Trang H., primary, Hagenbeek, Thijs J., primary, Lee, Ho-June, primary, Li, Jason, primary, Rose, Christopher M., primary, Lin, Eva, primary, Yu, Mamie, primary, Martin, Scott E., primary, Piskol, Robert, primary, Lacap, Jennifer A., primary, Sampath, Deepak, primary, Pham, Victoria C., primary, Modrusan, Zora, primary, Lill, Jennie R., primary, Klijn, Christiaan, primary, Malek, Shiva, primary, Chang, Matthew T., primary, and Dey, Anwesha, primary

Published
2023
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12. Data from An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer

Author

Bhakta, Sunil, primary, Crocker, Lisa M., primary, Chen, Yvonne, primary, Hazen, Meredith, primary, Schutten, Melissa M., primary, Li, Dongwei, primary, Kuijl, Coenraad, primary, Ohri, Rachana, primary, Zhong, Fiona, primary, Poon, Kirsten A., primary, Go, Mary Ann T., primary, Cheng, Eric, primary, Piskol, Robert, primary, Firestein, Ron, primary, Fourie-O'Donohue, Aimee, primary, Kozak, Katherine R., primary, Raab, Helga, primary, Hongo, Jo-Anne, primary, Sampath, Deepak, primary, Dennis, Mark S., primary, Scheller, Richard H., primary, Polakis, Paul, primary, and Junutula, Jagath R., primary

Published
2023
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13. Figure S1 from Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways

Author

Pham, Trang H., primary, Hagenbeek, Thijs J., primary, Lee, Ho-June, primary, Li, Jason, primary, Rose, Christopher M., primary, Lin, Eva, primary, Yu, Mamie, primary, Martin, Scott E., primary, Piskol, Robert, primary, Lacap, Jennifer A., primary, Sampath, Deepak, primary, Pham, Victoria C., primary, Modrusan, Zora, primary, Lill, Jennie R., primary, Klijn, Christiaan, primary, Malek, Shiva, primary, Chang, Matthew T., primary, and Dey, Anwesha, primary

Published
2023
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14. Data from Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways

Author

Pham, Trang H., primary, Hagenbeek, Thijs J., primary, Lee, Ho-June, primary, Li, Jason, primary, Rose, Christopher M., primary, Lin, Eva, primary, Yu, Mamie, primary, Martin, Scott E., primary, Piskol, Robert, primary, Lacap, Jennifer A., primary, Sampath, Deepak, primary, Pham, Victoria C., primary, Modrusan, Zora, primary, Lill, Jennie R., primary, Klijn, Christiaan, primary, Malek, Shiva, primary, Chang, Matthew T., primary, and Dey, Anwesha, primary

Published
2023
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15. Figures S1-S4, Tables S1-S2 from An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer

Author

Bhakta, Sunil, primary, Crocker, Lisa M., primary, Chen, Yvonne, primary, Hazen, Meredith, primary, Schutten, Melissa M., primary, Li, Dongwei, primary, Kuijl, Coenraad, primary, Ohri, Rachana, primary, Zhong, Fiona, primary, Poon, Kirsten A., primary, Go, Mary Ann T., primary, Cheng, Eric, primary, Piskol, Robert, primary, Firestein, Ron, primary, Fourie-O'Donohue, Aimee, primary, Kozak, Katherine R., primary, Raab, Helga, primary, Hongo, Jo-Anne, primary, Sampath, Deepak, primary, Dennis, Mark S., primary, Scheller, Richard H., primary, Polakis, Paul, primary, and Junutula, Jagath R., primary

Published
2023
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16. Supplementary Data Figures from A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

Author

Piskol, Robert, primary, Huw, Ling, primary, Sergin, Ismail, primary, Kljin, Christiaan, primary, Modrusan, Zora, primary, Kim, Doris, primary, Kljavin, Noelyn, primary, Tam, Rachel, primary, Patel, Rajesh, primary, Burton, Jeremy, primary, Penuel, Elicia, primary, Qu, Xueping, primary, Koeppen, Hartmut, primary, Sumiyoshi, Teiko, primary, de Sauvage, Frederic, primary, Lackner, Mark R., primary, de Sousa e Melo, Felipe, primary, and Kabbarah, Omar, primary

Published
2023
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17. Supplementary Data Tables from A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

Author

Piskol, Robert, primary, Huw, Ling, primary, Sergin, Ismail, primary, Kljin, Christiaan, primary, Modrusan, Zora, primary, Kim, Doris, primary, Kljavin, Noelyn, primary, Tam, Rachel, primary, Patel, Rajesh, primary, Burton, Jeremy, primary, Penuel, Elicia, primary, Qu, Xueping, primary, Koeppen, Hartmut, primary, Sumiyoshi, Teiko, primary, de Sauvage, Frederic, primary, Lackner, Mark R., primary, de Sousa e Melo, Felipe, primary, and Kabbarah, Omar, primary

Published
2023
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18. Constitutive protein degradation induces acute cell death via proteolysis products

Author

Chen, Si-Han, primary, Prakash, Sumit, additional, Helgason, Elizabeth, additional, Gilchrist, Caroline L., additional, Kenner, Lillian R., additional, Srinivasan, Rajini, additional, Sterne-Weiler, Tim, additional, Hafner, Marc, additional, Piskol, Robert, additional, Dueber, Erin C., additional, Hamidi, Habib, additional, Endres, Nicholas, additional, Ye, Xin, additional, Fairbrother, Wayne J., additional, and Wertz, Ingrid E., additional

Published
2023
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19. Dynamic landscape and regulation of RNA editing in mammals

Author

Tan, Meng How, Li, Qin, Shanmugam, Raghuvaran, Piskol, Robert, Kohler, Jennefer, Young, Amy N., Liu, Kaiwen Ivy, Zhang, Rui, Ramaswami, Gokul, Ariyoshi, Kentaro, Gupte, Ankita, Keegan, Liam P., George, Cyril X., Ramu, Avinash, Huang, Ni, Pollina, Elizabeth A., Leeman, Dena S., Rustighi, Alessandra, Goh, Y. P. Sharon, Aguet, Franois, Ardlie, Kristin G., Cummings, Beryl B., Gelfand, Ellen T., Getz, Gad, Hadley, Kane, Handsaker, Robert E., Huang, Katherine H., Kashin, Seva, Karczewski, Konrad J., Lek, Monkol, Li, Xiao, MacArthur, Daniel G., Nedzel, Jared L., Nguyen, Duyen T., Noble, Michael S., Segr, Ayellet V., Trowbridge, Casandra A., Tukiainen, Taru, Abell, Nathan S., Balliu, Brunilda, Barshir, Ruth, Basha, Omer, Battle, Alexis, Bogu, Gireesh K., Brown, Andrew, Brown, Christopher D., Castel, Stephane E., Chen, Lin S., Chiang, Colby, Conrad, Donald F., Cox, Nancy J., Damani, Farhan N., Davis, Joe R., Delaneau, Olivier, Dermitzakis, Emmanouil T., Engelhardt, Barbara E., Eskin, Eleazar, Ferreira, Pedro G., Frsard, Laure, Gamazon, Eric R., Garrido-Martn, Diego, Gewirtz, Ariel D. H., Gliner, Genna, Gloudemans, Michael J., Guigo, Roderic, Hall, Ira M., Han, Buhm, He, Yuan, Hormozdiari, Farhad, Howald, Cedric, Kyung Im, Hae, Jo, Brian, Yong Kang, Eun, Kim, Yungil, Kim-Hellmuth, Sarah, Lappalainen, Tuuli, Li, Gen, Li, Xin, Liu, Boxiang, Mangul, Serghei, McCarthy, Mark I., McDowell, Ian C., Mohammadi, Pejman, Monlong, Jean, Montgomery, Stephen B., Muoz-Aguirre, Manuel, Ndungu, Anne W., Nicolae, Dan L., Nobel, Andrew B., Oliva, Meritxell, Ongen, Halit, Palowitch, John J., Panousis, Nikolaos, Papasaikas, Panagiotis, Park, YoSon, Parsana, Princy, Payne, Anthony J., Peterson, Christine B., Quan, Jie, Reverter, Ferran, Sabatti, Chiara, Saha, Ashis, Sammeth, Michael, Scott, Alexandra J., Shabalin, Andrey A., Sodaei, Reza, Stephens, Matthew, Stranger, Barbara E., Strober, Benjamin J., Sul, Jae Hoon, Tsang, Emily K., Urbut, Sarah, van de Bunt, Martijn, Wang, Gao, Wen, Xiaoquan, Wright, Fred A., Xi, Hualin S., Yeger-Lotem, Esti, Zappala, Zachary, Zaugg, Judith B., Zhou, Yi-Hui, Akey, Joshua M., Bates, Daniel, Chan, Joanne, Claussnitzer, Melina, Demanelis, Kathryn, Diegel, Morgan, Doherty, Jennifer A., Feinberg, Andrew P., Fernando, Marian S., Halow, Jessica, Hansen, Kasper D., Haugen, Eric, Hickey, Peter F., Hou, Lei, Jasmine, Farzana, Jian, Ruiqi, Jiang, Lihua, Johnson, Audra, Kaul, Rajinder, Kellis, Manolis, Kibriya, Muhammad G., Lee, Kristen, Li, Jin Billy, Lin, Jessica, Lin, Shin, Linder, Sandra, Linke, Caroline, Liu, Yaping, Maurano, Matthew T., Molinie, Benoit, Nelson, Jemma, Neri, Fidencio J., Park, Yongjin, Pierce, Brandon L., Rinaldi, Nicola J., Rizzardi, Lindsay F., Sandstrom, Richard, Skol, Andrew, Smith, Kevin S., Snyder, Michael P., Stamatoyannopoulos, John, Tang, Hua, Wang, Li, Wang, Meng, Van Wittenberghe, Nicholas, Wu, Fan, Nierras, Concepcion R., Branton, Philip A., Carithers, Latarsha J., Guan, Ping, Moore, Helen M., Rao, Abhi, Vaught, Jimmie B., Gould, Sarah E., Lockart, Nicole C., Martin, Casey, Struewing, Jeffery P., Volpi, Simona, Addington, Anjene M., Koester, Susan E., Little, A. Roger, Brigham, Lori E., Hasz, Richard, Hunter, Marcus, Johns, Christopher, Johnson, Mark, Kopen, Gene, Leinweber, William F., Lonsdale, John T., McDonald, Alisa, Mestichelli, Bernadette, Myer, Kevin, Roe, Brian, Salvatore, Michael, Shad, Saboor, Thomas, Jeffrey A., Walters, Gary, Washington, Michael, Wheeler, Joseph, Bridge, Jason, Foster, Barbara A., Gillard, Bryan M., Karasik, Ellen, Kumar, Rachna, Miklos, Mark, Moser, Michael T., Jewell, Scott D., Montroy, Robert G., Rohrer, Daniel C., Valley, Dana R., Davis, David A., Mash, Deborah C., Undale, Anita H., Smith, Anna M., Tabor, David E., Roche, Nancy V., McLean, Jeffrey A., Vatanian, Negin, Robinson, Karna L., Sobin, Leslie, Barcus, Mary E., Valentino, Kimberly M., Qi, Liqun, Hunter, Steven, Hariharan, Pushpa, Singh, Shilpi, Um, Ki Sung, Matose, Takunda, Tomaszewski, Maria M., Barker, Laura K., Mosavel, Maghboeba, Siminoff, Laura A., Traino, Heather M., Flicek, Paul, Juettemann, Thomas, Ruffier, Magali, Sheppard, Dan, Taylor, Kieron, Trevanion, Stephen J., Zerbino, Daniel R., Craft, Brian, Goldman, Mary, Haeussler, Maximilian, Kent, W. James, Lee, Christopher M., Paten, Benedict, Rosenbloom, Kate R., Vivian, John, Zhu, Jingchun, Chawla, Ajay, Del Sal, Giannino, Peltz, Gary, Brunet, Anne, Samuel, Charles E., OConnell, Mary A., Walkley, Carl R., and Nishikura, Kazuko

Subjects
Genetic research, Mammals -- Genetic aspects, RNA processing -- Research, Genetic regulation, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Meng How Tan (corresponding author) [1, 2, 3]; Qin Li [1]; Raghuvaran Shanmugam [2, 3]; Robert Piskol [1]; Jennefer Kohler [1]; Amy N. Young [1]; Kaiwen Ivy Liu [3]; [...]

Published
2017
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20. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Author

de Sousa e Melo, Felipe, Kurtova, Antonina V., Harnoss, Jonathan M., Kljavin, Noelyn, Hoeck, Joerg D., Hung, Jeffrey, Anderson, Jeffrey Eastham, Storm, Elaine E., Modrusan, Zora, Koeppen, Hartmut, Dijkgraaf, Gerrit J. P., Piskol, Robert, and de Sauvage, Frederic J.

Subjects
Colon cancer -- Development and progression -- Genetic aspects, Stem cells -- Health aspects, Cancer metastasis -- Genetic aspects -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind tumour progression and metastasis, making them attractive cancer targets. However, conclusive experimental evidence for their functional relevance is still lacking for most malignancies. Here we show that the leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) identifies intestinal CSCs in mouse tumours engineered to recapitulate the clinical progression of human colorectal cancer. We demonstrate that selective Lgr5[sup.+] cell ablation restricts primary tumour growth, but does not result in tumour regression. Instead, tumours are maintained by proliferative Lgr5[sup.] cells that continuously attempt to replenish the Lgr5[sup.+] CSC pool, leading to rapid re-initiation of tumour growth upon treatment cessation. Notably, CSCs are critical for the formation and maintenance of liver metastasis derived from colorectal cancers. Together, our data highlight distinct CSC dependencies for primary versus metastasic tumour growth, and suggest that targeting CSCs may represent a therapeutic opportunity for managing metastatic disease., Author(s): Felipe de Sousa e Melo [1]; Antonina V. Kurtova [1]; Jonathan M. Harnoss [2]; Noelyn Kljavin [1]; Joerg D. Hoeck [1]; Jeffrey Hung [3]; Jeffrey Eastham Anderson [3]; Elaine [...]

Published
2017
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22. Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Author

Hansen, Simon, primary, Zhang, Yingnan, additional, Hwang, Sunhee, additional, Nabhan, Ahmad, additional, Li, Wanqing, additional, Fuhrmann, Jakob, additional, Kschonsak, Yvonne, additional, Zhou, Lijuan, additional, Nile, Aaron H., additional, Gao, Xinxin, additional, Piskol, Robert, additional, de Sousa e Melo, Felipe, additional, de Sauvage, Frederic J., additional, and Hannoush, Rami N., additional

Published
2022
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23. Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema

Author

Agard, Nicholas J., primary, Zhang, Gu, additional, Ridgeway, John, additional, Dicara, Danielle M., additional, Chu, Phillip Y., additional, Ohri, Rachana, additional, Sanowar, Sarah, additional, Vernes, Jean-Michel, additional, Chi, Hannah, additional, Zhang, Jiameng, additional, Holz, Emily, additional, Paluch, Maciej, additional, He, Guannan, additional, Benson, Yingjia, additional, Zhang, Jianhuan, additional, Chan, Pamela, additional, Tang, Nga, additional, Javale, Prachi, additional, Wilson, Blair, additional, Barrett, Kathy, additional, Rowntree, Rebecca K., additional, Hang, Julie, additional, Meng, Y. Gloria, additional, Hass, Phil, additional, Fuh, Germaine, additional, Piskol, Robert, additional, Bantseev, Vladimir, additional, Loyet, Kelly M., additional, Tran, John C., additional, Wu, Cong, additional, Indjeian, Vahan B., additional, Shivva, Vittal, additional, and Yan, Minhong, additional

Published
2022
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24. Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis

Author

Mosteiro, Lluc, primary, Thao Nguyen, Thi Thu, additional, Hankeova, Simona, additional, Reichelt, Mike, additional, Vandriel, Shannon M., additional, Lai, Zijuan, additional, Choudhury, Feroza K., additional, Sangaraju, Dewakar, additional, Kamath, Binita M., additional, Scherl, Alexis, additional, Piskol, Robert, additional, and Siebel, Christian W., additional

Published
2022
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27. Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

Author

Wang, Peiyin, primary, Sun, Liping L., additional, Clark, Robyn, additional, Hristopoulos, Maria, additional, Chiu, Cecilia P.C., additional, Dillon, Michael, additional, Lin, WeiYu, additional, Lo, Amy A., additional, Chalsani, Sreedevi, additional, Das Thakur, Meghna, additional, Zimmerman Savill, Kristin M., additional, Rougé, Lionel, additional, Lupardus, Patrick, additional, Piskol, Robert, additional, Husain, Bushra, additional, Ellerman, Diego, additional, Shivva, Vittal, additional, Leong, Steven R., additional, Ovacik, Meric, additional, Totpal, Klara, additional, Wu, Yan, additional, Spiess, Christoph, additional, Lee, Genee, additional, Leipold, Douglas D., additional, and Polson, Andrew G., additional

Published
2022
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28. CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Author

Venkatanarayan, Avinashnarayan, primary, Liang, Jason, additional, Yen, Ivana, additional, Shanahan, Frances, additional, Haley, Benjamin, additional, Phu, Lilian, additional, Verschueren, Erik, additional, Hinkle, Trent B., additional, Kan, David, additional, Segal, Ehud, additional, Long, Jason E., additional, Lima, Tony, additional, Liau, Nicholas P.D., additional, Sudhamsu, Jawahar, additional, Li, Jason, additional, Klijn, Christiaan, additional, Piskol, Robert, additional, Junttila, Melissa R., additional, Shaw, Andrey S., additional, Merchant, Mark, additional, Chang, Matthew T., additional, Kirkpatrick, Donald S., additional, and Malek, Shiva, additional

Published
2022
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29. Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Author

Chang, Matthew T., primary, Shanahan, Frances, additional, Nguyen, Thi Thu Thao, additional, Staben, Steven T., additional, Gazzard, Lewis, additional, Yamazoe, Sayumi, additional, Wertz, Ingrid E., additional, Piskol, Robert, additional, Yang, Yeqing Angela, additional, Modrusan, Zora, additional, Haley, Benjamin, additional, Evangelista, Marie, additional, Malek, Shiva, additional, Foster, Scott A., additional, and Ye, Xin, additional

Published
2021
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32. Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways

Author

Pham, Trang H., primary, Hagenbeek, Thijs J., additional, Lee, Ho-June, additional, Li, Jason, additional, Rose, Christopher M., additional, Lin, Eva, additional, Yu, Mamie, additional, Martin, Scott E., additional, Piskol, Robert, additional, Lacap, Jennifer A., additional, Sampath, Deepak, additional, Pham, Victoria C., additional, Modrusan, Zora, additional, Lill, Jennie R., additional, Klijn, Christiaan, additional, Malek, Shiva, additional, Chang, Matthew T., additional, and Dey, Anwesha, additional

Published
2021
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34. Abstract 5869: Characterization and therapeutic implications of SMARCA4 mutations in cancer

Author

Fernando, Tharu M., primary, Piskol, Robert, additional, Bainer, Russell, additional, Sokol, Ethan, additional, Trabucco, Sally, additional, Zhang, Qing, additional, Trinh, Huong, additional, Maund, Sophia, additional, Kschonsak, Marc, additional, Chaudhuri, Subhra, additional, Januario, Tom, additional, Modrusan, Zora, additional, and Yauch, Robert L., additional

Published
2020
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36. MAP4K4 negatively regulates CD8 T cell–mediated antitumor and antiviral immunity

Author

Esen, Emel, primary, Sergin, Ismail, additional, Jesudason, Rajiv, additional, Himmels, Patricia, additional, Webster, Joshua D., additional, Zhang, Hua, additional, Xu, Min, additional, Piskol, Robert, additional, McNamara, Erin, additional, Gould, Stephen, additional, Capietto, Aude-Hélène, additional, Delamarre, Lélia, additional, Walsh, Kevin, additional, and Ye, Weilan, additional

Published
2020
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37. Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Author

Zhou, Yi, primary, Fei, Mingjian, additional, Zhang, Gu, additional, Liang, Wei-Ching, additional, Lin, WeiYu, additional, Wu, Yan, additional, Piskol, Robert, additional, Ridgway, John, additional, McNamara, Erin, additional, Huang, Haochu, additional, Zhang, Juan, additional, Oh, Jaehak, additional, Patel, Jaina M., additional, Jakubiak, Diana, additional, Lau, Jeff, additional, Blackwood, Beth, additional, Bravo, Daniel D., additional, Shi, Yongchang, additional, Wang, Jianyong, additional, Hu, Hong-Ming, additional, Lee, Wyne P., additional, Jesudason, Rajiv, additional, Sangaraju, Dewakar, additional, Modrusan, Zora, additional, Anderson, Keith R., additional, Warming, Søren, additional, Roose-Girma, Merone, additional, and Yan, Minhong, additional

Published
2020
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39. Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer

Author

Bhakta, Sunil, primary, Crocker, Lisa M., additional, Chen, Yvonne, additional, Hazen, Meredith, additional, Schutten, Melissa M., additional, Li, Dongwei, additional, Kuijl, Coenraad, additional, Ohri, Rachana, additional, Zhong, Fiona, additional, Poon, Kirsten A., additional, Go, Mary Ann T., additional, Cheng, Eric, additional, Piskol, Robert, additional, Firestein, Ron, additional, Fourie-O'Donohue, Aimee, additional, Kozak, Katherine R., additional, Raab, Helga, additional, Hongo, Jo-Anne, additional, Sampath, Deepak, additional, Dennis, Mark S., additional, Scheller, Richard H., additional, Polakis, Paul, additional, and Junutula, Jagath R., additional

Published
2019
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41. A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

Author

Piskol, Robert, primary, Huw, Ling, additional, Sergin, Ismail, additional, Kljin, Christiaan, additional, Modrusan, Zora, additional, Kim, Doris, additional, Kljavin, Noelyn, additional, Tam, Rachel, additional, Patel, Rajesh, additional, Burton, Jeremy, additional, Penuel, Elicia, additional, Qu, Xueping, additional, Koeppen, Hartmut, additional, Sumiyoshi, Teiko, additional, de Sauvage, Frederic, additional, Lackner, Mark R., additional, de Sousa e Melo, Felipe, additional, and Kabbarah, Omar, additional

Published
2019
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42. NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

Author

Hegde, Ganapati V, primary, de la Cruz, Cecile, additional, Giltnane, Jennifer M, additional, Crocker, Lisa, additional, Venkatanarayan, Avinashnarayan, additional, Schaefer, Gabriele, additional, Dunlap, Debra, additional, Hoeck, Joerg D, additional, Piskol, Robert, additional, Gnad, Florian, additional, Modrusan, Zora, additional, de Sauvage, Frederic J, additional, Siebel, Christian W, additional, and Jackson, Erica L, additional

Published
2019
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43. Author response: NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

Author

Hegde, Ganapati V, primary, de la Cruz, Cecile, additional, Giltnane, Jennifer M, additional, Crocker, Lisa, additional, Venkatanarayan, Avinashnarayan, additional, Schaefer, Gabriele, additional, Dunlap, Debra, additional, Hoeck, Joerg D, additional, Piskol, Robert, additional, Gnad, Florian, additional, Modrusan, Zora, additional, de Sauvage, Frederic J, additional, Siebel, Christian W, additional, and Jackson, Erica L, additional

Published
2019
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44. ARAFmutations confer resistance to the RAF inhibitor belvarafenib in melanoma

Author

Yen, Ivana, Shanahan, Frances, Lee, Jeeyun, Hong, Yong Sang, Shin, Sang Joon, Moore, Amanda R., Sudhamsu, Jawahar, Chang, Matthew T., Bae, Inhwan, Dela Cruz, Darlene, Hunsaker, Thomas, Klijn, Christiaan, Liau, Nicholas P. D., Lin, Eva, Martin, Scott E., Modrusan, Zora, Piskol, Robert, Segal, Ehud, Venkatanarayan, Avinashnarayan, Ye, Xin, Yin, Jianping, Zhang, Liangxuan, Kim, Jin-Soo, Lim, Hyeong-Seok, Kim, Kyu-Pyo, Kim, Yu Jung, Han, Hye Sook, Lee, Soo Jung, Kim, Seung Tae, Jung, Minkyu, Hong, Yoon-hee, Noh, Young Su, Choi, Munjeong, Han, Oakpil, Nowicka, Malgorzata, Srinivasan, Shrividhya, Yan, Yibing, Kim, Tae Won, and Malek, Shiva

Abstract

Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAFV600-mutant melanoma, they are ineffective in non-BRAFV600mutant cells1–3. Belvarafenib is a potent and selective RAF dimer (type II) inhibitor that exhibits clinical activity in patients with BRAFV600E-and NRAS-mutant melanomas. Here we report the first-in-human phase I study investigating the maximum tolerated dose, and assessing the safety and preliminary efficacy of belvarafenib in BRAFV600E- and RAS-mutated advanced solid tumours (NCT02405065, NCT03118817). By generating belvarafenib-resistant NRAS-mutant melanoma cells and analysing circulating tumour DNA from patients treated with belvarafenib, we identified new recurrent mutations in ARAFwithin the kinase domain. ARAF mutants conferred resistance to belvarafenib in both a dimer- and a kinase activity-dependent manner. Belvarafenib induced ARAF mutant dimers, and dimers containing mutant ARAF were active in the presence of inhibitor. ARAFmutations may serve as a general resistance mechanism for RAF dimer inhibitors as the mutants exhibit reduced sensitivity to a panel of type II RAF inhibitors. The combination of RAF plus MEK inhibition may be used to delay ARAF-driven resistance and suggests a rational combination for clinical use. Together, our findings reveal specific and compensatory functions for the ARAF isoform and implicate ARAFmutations as a driver of resistance to RAF dimer inhibitors.

Published
2021
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45. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells

Author

Nile, Aaron H., primary, de Sousa e Melo, Felipe, additional, Mukund, Susmith, additional, Piskol, Robert, additional, Hansen, Simon, additional, Zhou, Lijuan, additional, Zhang, Yingnan, additional, Fu, Yue, additional, Gogol, Emily B., additional, Kömüves, László G., additional, Modrusan, Zora, additional, Angers, Stephane, additional, Franke, Yvonne, additional, Koth, Christopher, additional, Fairbrother, Wayne J., additional, Wang, Weiru, additional, de Sauvage, Frederic J., additional, and Hannoush, Rami N., additional

Published
2018
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46. An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer

Author

Bhakta, Sunil, primary, Crocker, Lisa M., additional, Chen, Yvonne, additional, Hazen, Meredith, additional, Schutten, Melissa M., additional, Li, Dongwei, additional, Kuijl, Coenraad, additional, Ohri, Rachana, additional, Zhong, Fiona, additional, Poon, Kirsten A., additional, Go, Mary Ann T., additional, Cheng, Eric, additional, Piskol, Robert, additional, Firestein, Ron, additional, Fourie-O'Donohue, Aimee, additional, Kozak, Katherine R., additional, Raab, Helga, additional, Hongo, Jo-Anne, additional, Sampath, Deepak, additional, Dennis, Mark S., additional, Scheller, Richard H., additional, Polakis, Paul, additional, and Junutula, Jagath R., additional

Published
2018
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47. Dynamic landscape and regulation of RNA editing in mammals.

Author

Tan, Meng, Tan, Meng, Li, Qin, Shanmugam, Raghuvaran, Piskol, Robert, Kohler, Jennefer, Young, Amy, Liu, Kaiwen, Zhang, Rui, Ramaswami, Gokul, Ariyoshi, Kentaro, Gupte, Ankita, Keegan, Liam, George, Cyril, Ramu, Avinash, Huang, Ni, Pollina, Elizabeth, Leeman, Dena, Rustighi, Alessandra, Goh, Y, Del Sal, Giannino, Peltz, Gary, Brunet, Anne, Conrad, Donald, Samuel, Charles, OConnell, Mary, Walkley, Carl, Nishikura, Kazuko, Li, Jin, Chawla, Ajay, Tan, Meng, Tan, Meng, Li, Qin, Shanmugam, Raghuvaran, Piskol, Robert, Kohler, Jennefer, Young, Amy, Liu, Kaiwen, Zhang, Rui, Ramaswami, Gokul, Ariyoshi, Kentaro, Gupte, Ankita, Keegan, Liam, George, Cyril, Ramu, Avinash, Huang, Ni, Pollina, Elizabeth, Leeman, Dena, Rustighi, Alessandra, Goh, Y, Del Sal, Giannino, Peltz, Gary, Brunet, Anne, Conrad, Donald, Samuel, Charles, OConnell, Mary, Walkley, Carl, Nishikura, Kazuko, Li, Jin, and Chawla, Ajay

Abstract

Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules. Although many editing sites have recently been discovered, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood. Here we report dynamic spatiotemporal patterns and new regulators of RNA editing, discovered through an extensive profiling of A-to-I RNA editing in 8,551 human samples (representing 53 body sites from 552 individuals) from the Genotype-Tissue Expression (GTEx) project and in hundreds of other primate and mouse samples. We show that editing levels in non-repetitive coding regions vary more between tissues than editing levels in repetitive regions. Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary editor of non-repetitive coding sites, whereas the catalytically inactive ADAR3 predominantly acts as an inhibitor of editing. Cross-species analysis of RNA editing in several tissues revealed that species, rather than tissue type, is the primary determinant of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation. In addition, we curated an extensive set of ADAR1 and ADAR2 targets and showed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo. Further analysis of the GTEx data revealed several potential regulators of editing, such as AIMP2, which reduces editing in muscles by enhancing the degradation of the ADAR proteins. Collectively, our work provides insights into the complex cis- and trans-regulation of A-to-I editing.

Published
2017

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