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10 results on '"Pitcheshwar, Priyankaa"'

5. MiR-138 is a potent regulator of the heterogenous MYC transcript population in cancers

Author

Desi, Ng, primary, Teh, Velda, additional, Tong, Qing Yun, additional, Lim, Chun You, additional, Tabatabaeian, Hossein, additional, Chew, Xiao Hong, additional, Sanchez-Mejias, Avencia, additional, Chan, Jia Jia, additional, Zhang, Bin, additional, Pitcheshwar, Priyankaa, additional, Siew, Bei-En, additional, Wang, Shi, additional, Lee, Kuok-Chung, additional, Chong, Choon-Seng, additional, Cheong, Wai-Kit, additional, Lieske, Bettina, additional, Tan, Ian Jse-Wei, additional, Tan, Ker-Kan, additional, and Tay, Yvonne, additional

Published
2021
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6. RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis

Author

Song, Yangyang, primary, An, Omer, additional, Ren, Xi, additional, Chan, Tim Hon Man, additional, Tay, Daryl Jin Tai, additional, Tang, Sze Jing, additional, Han, Jian, additional, Hong, HuiQi, additional, Ng, Vanessa Hui En, additional, Ke, Xinyu, additional, Shen, Haoqing, additional, Pitcheshwar, Priyankaa, additional, Lin, Jaymie Siqi, additional, Leong, Ka Wai, additional, Molias, Fernando Bellido, additional, Yang, Henry, additional, Kappei, Dennis, additional, and Chen, Leilei, additional

Published
2021
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7. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression

Author

Han, Jian, primary, An, Omer, additional, Hong, HuiQi, additional, Chan, Tim Hon Man, additional, Song, Yangyang, additional, Shen, Haoqing, additional, Tang, Sze Jing, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Tay, Daryl Jin Tai, additional, Molias, Fernando Bellido, additional, Pitcheshwar, Priyankaa, additional, Tan, Hui Qing, additional, Yang, Henry, additional, and Chen, Leilei, additional

Published
2020
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8. Hepatic Resection Following Selective Internal Radiation Therapy for Colorectal Cancer Metastases in the FOXFIRE Clinical Trial: Clinical Outcomes and Distribution of Microspheres

Author

Winter, Helen, primary, Rassam, Joseph, additional, Virdee, Pradeep S., additional, Goldin, Rob, additional, Pitcheshwar, Priyankaa, additional, Weaver, Klara, additional, Primrose, John, additional, Berry, David P., additional, Wasan, Harpreet S., additional, and Sharma, Ricky A., additional

Published
2019
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9. MiR-138 is a potent regulator of the heterogenous MYCtranscript population in cancers

Author

Desi, Ng, Teh, Velda, Tong, Qing Yun, Lim, Chun You, Tabatabaeian, Hossein, Chew, Xiao Hong, Sanchez-Mejias, Avencia, Chan, Jia Jia, Zhang, Bin, Pitcheshwar, Priyankaa, Siew, Bei-En, Wang, Shi, Lee, Kuok-Chung, Chong, Choon-Seng, Cheong, Wai-Kit, Lieske, Bettina, Tan, Ian Jse-Wei, Tan, Ker-Kan, and Tay, Yvonne

Abstract

3′UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in cancer cells. One of the most well-studied oncogenes is the transcription factor MYC, which is overexpressed in more than half of all cancers. MYCoverexpression is not always accompanied by underlying genetic aberrations. In this study, we demonstrate that the MYC3′UTR is shortened in colorectal cancer (CRC). Using unbiased computational and experimental approaches, we identify and validate microRNAs that target the MYCcoding region. In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines. Critically, the intravenous administration of miR-138 significantly impedes MYC-driven tumor growth in vivo. Taken together, our results highlight the previously uncharacterized shortening of the MYC3′UTR in cancer, and identify miR-138 as a potent regulator of the heterogenous MYCtranscript population.

Published
2021
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10. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.

Author

Jian Han, An, Omer, HuiQi Hong, Hon Man Chan, Tim, Yangyang Song, Haoqing Shen, Sze Jing Tang, Lin, Jaymie Siqi, Hui En Ng, Vanessa, Jin Tai Tay, Daryl, Molias, Fernando Bellido, Pitcheshwar, Priyankaa, Hui Qing Tan, Yang, Henry, and Leilei Chen

Subjects
*CANCER invasiveness, *RNA splicing, *RNA, *RNA-binding proteins, *ALTERNATIVE RNA splicing, *GREEN fluorescent protein, *TRANSFER RNA, *ISOMERASES
Abstract

In this article, author uncover death associated protein 3 (DAP3) as a potent repressor of editing and a strong oncogene in cancer. It discusses the suppression of adenosine-to-inosine RNA editome by death associated protein 3 (DAP3) promotes cancer progression. It mentions the negative regulation of editing mechanism by which DAP3 promotes cancer development.

Published
2020
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