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The article discusses the role of plectin, a cytoskeletal protein, in the growth and metastasis of hepatocellular carcinoma (HCC), the most common primary liver malignancy. Elevated levels of plectin in liver tumors were found to correlate with poor prognosis for HCC patients. Genetic and pharmacological inhibition of plectin suppressed HCC initiation, growth, invasion potential, and metastatic outgrowth in mouse models, suggesting that targeting plectin may be a promising therapeutic strategy for HCC treatment. The study highlights the importance of plectin-controlled cytoarchitecture in HCC development and proposes disrupting mechanical homeostasis as a potential new therapeutic approach. [Extracted from the article]

A clinical trial, NCT06651346, aims to improve the diagnosis of cholangiocarcinoma, a type of cancer, by detecting cell-surface plectin in ERCP-directed biliary samples. The current diagnostic method has a low yield, leading to late-stage diagnoses with limited treatment options. By utilizing immunohistochemistry to identify plectin expression, researchers hope to develop a more sensitive diagnostic tool that can expedite the diagnosis process. The trial is observational, with a target enrollment of 100 participants and a completion date of January 1, 2027. [Extracted from the article]

A preprint abstract discusses the role of SERPINB5 in modulating desmoplakin membrane localization to improve clinical outcomes in pemphigus vulgaris (PV), an autoimmune skin blistering disorder. SERPINB5 overexpression prevents PV-IgG-mediated loss of cell-cell adhesion and loss of desmoplakin from the cell membrane. The study suggests that SERPINB5 regulates TGF-{beta} signaling, which destabilizes desmoplakin in keratinocytes, and identifies TGF-{beta} signaling as a potential target for pemphigus treatment. [Extracted from the article]

A recent study from the Cardiology Unit in Naples, Italy, explores the genetic factors associated with myocarditis, an inflammatory condition of the heart tissue. The research suggests that genetic susceptibility may play a role in the development of myocarditis and its related complications, such as arrhythmogenic cardiomyopathy. Identifying these genetic markers could improve diagnosis, risk assessment, and treatment strategies for patients with myocarditis. The study emphasizes the importance of understanding the interplay between genetic factors and environmental triggers in the pathogenesis of myocarditis. [Extracted from the article]

A recent study conducted by researchers at Johns Hopkins University focused on the clinical features and outcomes of individuals with pathogenic desmoplakin (DSP) variants, which are associated with a distinct form of arrhythmogenic cardiomyopathy. The study included 800 patients from 26 academic institutions across nine countries. The findings revealed that patients with DSP variants experienced high rates of sustained ventricular arrhythmias and heart failure hospitalizations. Risk factors for adverse outcomes included prior ventricular arrhythmias, T-wave inversion on electrocardiogram, left ventricular ejection fraction below 50%, and myocardial injury events. [Extracted from the article]

A recent study conducted at University Hospital in Kettering, United Kingdom, focused on a rare form of cardiomyopathy called Desmoplakin (DSP) cardiomyopathy. This condition is characterized by left ventricular involvement, extensive fibrosis, high arrhythmic risk, and episodes of acute myocardial injury. The study reported on the diagnosis and management of a rare case of DSP cardiomyopathy in a patient in his 70s who presented with symptoms of shortness of breath, recurrent chest infections, and ventricular ectopic. The patient was found to have impaired systolic function and was diagnosed with DSP cardiomyopathy through genetic testing. The study concluded that implantable cardioverter-defibrillator implantation should be considered for patients with left ventricular ejection fraction thresholds >35% and additional risk factors. [Extracted from the article]

A recent study conducted by researchers at Chongqing University in China explores the role of the plectin gene in cancer progression. Plectin is a cytoskeletal linking protein that interacts with intermediate filaments, microtubules, and actin filaments. The study highlights the dual participation of plectin in tumor progression, with both tumor-suppressive and tumor-promoting functions. The researchers aim to deepen the understanding of plectin's role in cancer and contribute to the development of novel therapeutic strategies and drug targets. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of plectin, a cytoskeletal crosslinker protein, in hepatocellular carcinoma (HCC), the most common primary malignancy of the liver. The study found that elevated levels of plectin in liver tumors correlated with poor prognosis for HCC patients. Genetic and pharmacological inactivation of plectin suppressed the initiation and growth of HCC, inhibited the invasion potential of HCC cells, and reduced metastatic outgrowth in the lung. The study suggests that targeting plectin and disrupting mechanical homeostasis may be a new therapeutic strategy for HCC treatment. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at Johns Hopkins University has developed a novel tool for assessing the risk of arrhythmia in individuals with pathogenic desmoplakin (DSP) gene variants. DSP cardiomyopathy, a distinct form of arrhythmogenic cardiomyopathy, is associated with these gene variants. The tool utilizes readily available clinical parameters to predict the development of ventricular arrhythmia (VA) in DSP patients. The model demonstrated good risk discrimination and may aid in decision-making for implantable cardioverter-defibrillator placement in this high-risk population. [Extracted from the article]

A recent study conducted by researchers at the University of Paris explores the role of plakins in the regulation of centrosome position in polarized epithelial cells. The researchers found that low levels of epiplakin, desmoplakin, and periplakin were associated with centrosome mispositioning in cells that had undergone the epithelial-to-mesenchymal transition (EMT) or tissue transformation. The downregulation of these plakins disrupted centrosome polarization towards intercellular junctions without affecting microtubule stability. These findings suggest that the downregulation of plakins and subsequent centrosome mispositioning are key factors in the disorganization of cytoskeleton networks, weakening of intercellular junctions, and loss of polarity in breast cancer cells. This research provides potential new markers for early stages of tumor development. [Extracted from the article]

Researchers at Leibniz-Forschungsinstitut fur Molekulare Pharmakologie in Berlin, Germany have developed a new fluorescent probe that targets plectin-1 and improves the imaging of pancreatic ductal adenocarcinoma (PDAC) in human tissue and in vivo. PDAC is a highly aggressive and lethal form of pancreatic cancer with poor patient survival rates. The lack of effective diagnostic tools for early detection is a major challenge in treating PDAC. This new probe shows promise in enabling early diagnosis and improving clinical understanding of PDAC progression. [Extracted from the article]

A recent report from Johns Hopkins University discusses a case of a young patient with chest pain. The patient was initially suspected to have acute myocarditis based on lab tests and cardiac imaging, but genetic testing revealed a diagnosis of desmoplakin cardiomyopathy. The researchers suggest that desmoplakin cardiomyopathy should be considered in patients with recurrent acute myocarditis or a family history of cardiac disease to avoid misdiagnosis. This research has been peer-reviewed and is published in The International Journal of Cardiovascular Imaging. [Extracted from the article]

A recent report from University Hospital Geneva discusses a case of desmoplakin cardiomyopathy, a type of non-dilated left ventricular cardiomyopathy characterized by inflammatory-like episodes, fibrosis/dysfunction of the left ventricle, and ventricular arrhythmias. The report describes the case of a 46-year-old Caucasian woman who experienced repeated sudden cardiac arrests and was found to have a new variant in the desmoplakin gene. The patient was treated with immunosuppressors, but only showed minimal improvement on imaging. The researchers suggest that desmoplakin cardiomyopathy should be considered in the diagnosis of inflammatory cardiomyopathies, and that immunosuppressive treatments may be reasonable for selected patients. [Extracted from the article]

A recent study conducted at Yamaguchi University in Japan has reported new findings on Epidermolysis Bullosa Simplex (EBS), a group of inherited disorders characterized by blistering of the skin and mucous membranes. The study focused on a severe case of EBS with pyloric atresia (PA), a condition that affects the digestive system. The researchers identified two novel compound heterozygous mutations in the plectin (PLEC) gene, which led to the diagnosis of EBS simplex with PA. The study highlights the important role of plectin in various organs and provides valuable information on the phenotypes resulting from mutations in the PLEC gene. [Extracted from the article]

A recent study conducted at the Royal Prince Alfred Hospital discusses the findings on myocarditis, specifically focusing on a rare genetic condition called desmoplakin cardiomyopathy. This condition is characterized by repeated inflammatory myocardial injury and is associated with ventricular arrhythmia and sudden cardiac death. The study highlights the challenges in diagnosing this condition and emphasizes the importance of genetic testing and advanced imaging techniques. The management of desmoplakin cardiomyopathy involves immunosuppression therapies and the insertion of an implantable cardiac defibrillator to prevent sudden cardiac death. The research concludes that further understanding of the management of cardiomyopathies with an inflammatory component is needed, and careful risk stratification is necessary for genetic variants like desmoplakin cardiomyopathy due to the increased risk of sudden cardiac death. [Extracted from the article]

A patent has been issued for a new treatment for cancer involving the use of Plectin-targeted liposomes and PARP inhibitors. The treatment is specifically aimed at individuals with BRCA1/2 mutations, which are associated with a high risk of breast, pancreas, and ovarian cancers. While PARP inhibitors have been approved for use in these patients, they can have adverse side effects. The new treatment aims to decrease tumor volume and increase the efficacy of PARP inhibitors by delivering them directly to cancer cells using Plectin-targeted liposomes. [Extracted from the article]

A new study on Alzheimer's disease has identified the cytoskeletal protein Plectin (PLEC) as a potential risk factor for the disease. The researchers hypothesize that PLEC dysfunction disrupts cytoskeletal homeostasis and synaptic function, increasing susceptibility to Alzheimer's. The study utilized genetic and proteomic analyses, as well as animal and cell culture models, to validate Plectin's role in Tau-induced neurotoxicity and neurodegeneration. The findings suggest that Plectin regulates Tau dynamics and neuronal function, providing insights into the underlying biology of Alzheimer's disease. [Extracted from the article]

Keywords for this news article include: Guangzhou, People's Republic of China, Asia, Acute Lung Injury, Blood Diseases and Conditions, Bloodstream Infection, Desmoplakins, Health and Medicine, Lung Diseases and Conditions, Lung Injury, Plakins, Proteins, Respiratory Tract Diseases and Conditions, Sepsis, Septicemia, Southern Medical University. Keywords: Guangzhou; People's Republic of China; Asia; Acute Lung Injury; Blood Diseases and Conditions; Bloodstream Infection; Desmoplakins; Health and Medicine; Lung Diseases and Conditions; Lung Injury; Plakins; Proteins; Respiratory Tract Diseases and Conditions; Sepsis; Septicemia EN Guangzhou People's Republic of China Asia Acute Lung Injury Blood Diseases and Conditions Bloodstream Infection Desmoplakins Health and Medicine Lung Diseases and Conditions Lung Injury Plakins Proteins Respiratory Tract Diseases and Conditions Sepsis Septicemia 189 189 1 11/06/23 20231109 NES 231109 2023 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- A new study on Lung Diseases and Conditions - Acute Lung Injury is now available. [Extracted from the article]

For more information on this research see: Desmoplakin I/ii Immunohistochemical Staining May Be a Helpful Tool In Differentiating Cutaneous Graft Versus Host Disease From the Erythema Multiforme, Stevens-johnson Syndrome, and Toxic Epidermal Necrolysis Spectrum Disorders. Keywords: Seattle; State:Washington; United States; North and Central America; Dermatology; Desmoplakins; Erythema; Erythema Multiforme; Graft-Versus-Host Disease; Health and Medicine; Immune System Diseases and Conditions; Plakins; Proteins; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Stevens-Johnson Syndrome; Stomatitis; Toxic Epidermal Necrolysis; Vesiculobullous Skin Diseases and Conditions EN Seattle State:Washington United States North and Central America Dermatology Desmoplakins Erythema Erythema Multiforme Graft-Versus-Host Disease Health and Medicine Immune System Diseases and Conditions Plakins Proteins Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Stevens-Johnson Syndrome Stomatitis Toxic Epidermal Necrolysis Vesiculobullous Skin Diseases and Conditions 4621 4621 1 10/09/23 20231013 NES 231013 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Skin Diseases and Conditions - Toxic Epidermal Necrolysis. [Extracted from the article]

Keywords: Nantong; People's Republic of China; Asia; Antiparasitics; Genetics; Pediatrics; Phosphoproteins; Plakins; Plectin; Proteins EN Nantong People's Republic of China Asia Antiparasitics Genetics Pediatrics Phosphoproteins Plakins Plectin Proteins 37 37 1 07/17/23 20230717 NES 230717 2023 JUL 22 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Proteins - Plakins is the subject of a report. Keywords for this news article include: Asia, Antiparasitics, Nantong, Plakins, Plectin, Genetics, Pediatrics, Phosphoproteins, People's Republic of China. [Extracted from the article]

The method of claim 1, wherein administration of the pharmaceutical composition comprising CoQ10 to an affected area containing at least one blister and/or wound for a treatment duration of about four weeks results in at least 70% reduction in the size of the affected area containing at least one blister and/or wound. The method of claim 25, wherein administration of the pharmaceutical composition comprising CoQ10 to an affected area containing at least one blister and/or wound for a treatment duration of about four weeks results in at least 70% reduction in the size of the affected area containing at least one blister and/or wound. A method of treating a wound associated with Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of CoQ10 to the wound in the subject. Traditionally, it was asserted that there were three major groups of inherited EB, namely EB simplex, junctional EB and dystrophic EB; based on the ultrastructural level within which skin cleaves and blisters. [Extracted from the article]

Keywords for this news article include: Onassis Cardiac Surgery Center, Genetics, Proteins, Desmoplakins. Keywords: Desmoplakins; Genetics; Plakins; Proteins EN Desmoplakins Genetics Plakins Proteins 574 574 1 05/22/23 20230522 NES 230522 2023 MAY 22 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on plakins have been presented. [Extracted from the article]

According to news reporting originating from Vienna, Austria, by NewsRx correspondents, research stated, "Plectin, a highly versatile cytolinker protein, is crucial for myofiber integrity and function." Keywords: Antiparasitics; Desmin; Intermediate Filament Proteins; Phosphoproteins; Plakins; Plectin; Proteins EN Antiparasitics Desmin Intermediate Filament Proteins Phosphoproteins Plakins Plectin Proteins 800 800 1 05/15/23 20230519 NES 230519 2023 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in plakins. [Extracted from the article]

Keywords: Sydney; Australia; Australia and New Zealand; Arrhythmia; Cardiology; Cardiomyopathies; Cardiovascular Diseases and Conditions; Desmoplakins; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Plakins; Proteins; Risk and Prevention EN Sydney Australia Australia and New Zealand Arrhythmia Cardiology Cardiomyopathies Cardiovascular Diseases and Conditions Desmoplakins Health and Medicine Heart Disease Heart Disorders and Diseases Plakins Proteins Risk and Prevention 747 747 1 04/17/23 20230417 NES 230417 2023 APR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Heart Disorders and Diseases - Cardiomyopathies. We evaluated phenotype, risk factors for ventricular arrhythmias, and underlying genetics of DSPtv cardiomyopathy.". [Extracted from the article]