41 results on '"Plamper, Andreas"'
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2. Health-related quality of life outcomes following Roux-en-Y gastric bypass versus one anastomosis gastric bypass
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Rheinwalt, Karl Peter, Fobbe, Anna, Plamper, Andreas, Alizai, Patrick Hamid, Schmitz, Sophia Marie-Therese, Brol, Maximilian Joseph, Trebicka, Jonel, Neumann, Ulf Peter, and Ulmer, Tom Florian
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- 2023
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3. Potenzielle Patientengefährdung durch europakonforme Neuregulierung auch in der Adipositaschirurgie
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Rheinwalt, Karl Peter and Plamper, Andreas
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- 2023
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4. A Long-Term Comparative Study Between One Anastomosis Gastric Bypass and Sleeve Gastrectomy
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Plamper, Andreas, Lingohr, Philipp, Nadal, Jennifer, Trebicka, Jonel, Brol, Maximilian J., Woestemeier, Anna, Schmitz, Sophia M.-T., Alizai, Patrick H., Neumann, Ulf P., Ulmer, Tom F., and Rheinwalt, Karl P.
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- 2023
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5. Clinical outcomes after one anastomosis gastric bypass versus sleeve gastrectomy in super-super-obese patients
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Schmitz, Sophia M.-T., Alizai, Patrick H., Kroh, Andreas, Schipper, Sandra, Brozat, Jonathan F., Plamper, Andreas, Neumann, Ulf P., Rheinwalt, Karl, and Ulmer, Tom F.
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- 2022
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6. Roux-en-Y Versus One Anastomosis Gastric Bypass as Redo-Operations Following Sleeve Gastrectomy: A Retrospective Study
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Rheinwalt, Karl Peter, Schipper, Sandra, Plamper, Andreas, Alizai, Patrick Hamid, Trebicka, Jonel, Brol, Maximilian Joseph, Kroh, Andreas, Schmitz, Sophia, Parmar, Chetan, Neumann, Ulf Peter, and Ulmer, Tom Florian
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- 2022
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7. Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study
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Pędziwiatr, Michał, Major, Piotr, Zarzycki, Piotr, Pantelis, Athanasios, Lapatsanis, Dimitris P., Stravodimos, Georgios, Matthys, Chris, Focquet, Marc, Vleeschouwers, Wouter, Spaventa, Antonio G., Zerrweck, Carlos, Vitiello, Antonio, Berardi, Giovanna, Musella, Mario, Sanchez-Meza, Alberto, Cantu, Felipe J., Jr, Mora, Fernando, Cantu, Marco A., Katakwar, Abhishek, Reddy, D. Nageshwar, Elmaleh, Haitham, Hassan, Mohammad, Elghandour, Abdelrahman, Elbanna, Mohey, Osman, Ahmed, Khan, Athar, Layani, Laurent, Kiran, Nalini, Velikorechin, Andrey, Solovyeva, Maria, Melali, Hamid, Shahabi, Shahab, Agrawal, Ashish, Shrivastava, Apoorv, Sharma, Ankur, Narwaria, Bhavya, Narwaria, Mahendra, Raziel, Asnat, Sakran, Nasser, Susmallian, Sergio, Karagöz, Levent, Akbaba, Murat, Pişkin, Salih Zeki, Balta, Ahmet Ziya, Senol, Zafer, Manno, Emilio, Iovino, Michele Giuseppe, Qassem, Mohamed, Arana-Garza, Sebastián, Povoas, Heitor P., Vilas-Boas, Marcos Leão, Li, Alan, Ammori, Basil J., Balamoun, Hany, Salman, Mohammed, Nasta, Amrit Manik, Goel, Ramen, Sánchez-Aguilar, Hugo, Herrera, Miguel F., Abou-Mrad, Adel, Cloix, Lucie, Mazzini, Guilherme Silva, Kristem, Leonardo, Lazaro, Andre, Campos, Jose, Bernardo, Joaquín, González, Jesús, Trindade, Carlos, Viveiros, Octávio, Ribeiro, Rui, Goitein, David, Hazzan, David, Segev, Lior, Beck, Tamar, Reyes, Hernán, Monterrubio, Jerónimo, García, Paulina, Benois, Marine, Kassir, Radwan, Contine, Alessandro, Elshafei, Moustafa, Aktas, Sueleyman, Weiner, Sylvia, Heidsieck, Till, Level, Luis, Pinango, Silvia, Ortega, Patricia Martinez, Moncada, Rafael, Valenti, Victor, Vlahović, Ivan, Boras, Zdenko, Liagre, Arnaud, Martini, Francesco, Juglard, Gildas, Motwani, Manish, Saggu, Sukhvinder Singh, Momani, Hazem Al, López, Luis Adolfo Aceves, Cortez, María Angelina Contreras, Zavala, Rodrigo Aceves, D'Haese, Christine, Kempeneers, Ivo, Himpens, Jacques, Lazzati, Andrea, Paolino, Luca, Bathaei, Sarah, Bedirli, Abdulkadir, Yavuz, Aydın, Büyükkasap, Çağrı, Özaydın, Safa, Kwiatkowski, Andrzej, Bartosiak, Katarzyna, Walędziak, Maciej, Santonicola, Antonella, Angrisani, Luigi, Iovino, Paola, Palma, Rossella, Iossa, Angelo, Boru, Cristian Eugeniu, Angelis, Francesco De, Silecchia, Gianfranco, Hussain, Abdulzahra, Balchandra, Srivinasan, Coltell, Izaskun Balciscueta, Pérez, Javier Lorenzo, Bohra, Ashok, Awan, Altaf K., Madhok, Brijesh, Leeder, Paul C., Awad, Sherif, Al-Khyatt, Waleed, Shoma, Ashraf, Elghadban, Hosam, Ghareeb, Sameh, Mathews, Bryan, Kurian, Marina, Larentzakis, Andreas, Vrakopoulou, Gavriella Zoi, Albanopoulos, Konstantinos, Bozdag, Ahemt, Lale, Azmi, Kirkil, Cuneyt, Dincer, Mursid, Bashir, Ahmad, Haddad, Ashraf, Hijleh, Leen Abu, Zilberstein, Bruno, de Marchi, Danilo Dallago, Souza, Willy Petrini, Brodén, Carl Magnus, Gislason, Hjörtur, Shah, Kamran, Ambrosi, Antonio, Pavone, Giovanna, Tartaglia, Nicola, Kumari Kona, S. Lakshmi, Kalyan, K., Perez, Cesar Ernesto Guevara, Botero, Miguel Alberto Forero, Covic, Adrian, Timofte, Daniel, Maxim, Madalina, Faraj, Dashti, Tseng, Larissa, Liem, Ronald, Ören, Gürdal, Dilektasli, Evren, Yalcin, Ilker, AlMukhtar, Hudhaifa, Hadad, Mohammed Al, Mohan, Rasmi, Arora, Naresh, Bedi, Digvijaysingh, Rives-Lange, Claire, Chevallier, Jean-Marc, Poghosyan, Tigran, Sebbag, Hugues, Zinaï, Lamia, Khaldi, Saadi, Mauchien, Charles, Mazza, Davide, Dinescu, Georgiana, Rea, Bernardo, Pérez-Galaz, Fernando, Zavala, Luis, Besa, Anais, Curell, Anna, Balibrea, Jose M., Vaz, Carlos, Galindo, Luis, Silva, Nelson, Caballero, José Luis Estrada, Sebastian, Sergio Ortiz, Marchesini, João Caetano Dallegrave, da Fonseca Pereira, Ricardo Arcanjo, Sobottka, Wagner Herbert, Fiolo, Felipe Eduardo, Turchi, Matias, Coelho, Antonio Claudio Jamel, Zacaron, Andre Luis, Barbosa, André, Quinino, Reynaldo, Menaldi, Gabriel, Paleari, Nicolás, Martinez-Duartez, Pedro, de Aragon Ramírez de Esparza, Gabriel Martínez, Esteban, Valentin Sierra, Torres, Antonio, Garcia-Galocha, Jose Luis, Josa, Miguel, Pacheco-Garcia, Jose Manuel, Mayo-Ossorio, Maria Angeles, Chowbey, Pradeep, Soni, Vandana, de Vasconcelos Cunha, Hercio Azevedo, Castilho, Michel Victor, Ferreira, Rafael Meneguzzi Alves, Barreiro, Thiago Alvim, Charalabopoulos, Alexandros, Sdralis, Elias, Davakis, Spyridon, Bomans, Benoit, Dapri, Giovanni, Belle, Koenraad Van, Takieddine, Mazen, Vaneukem, Pol, Karaca, Esma Seda Akalın, Karaca, Fatih Can, Sumer, Aziz, Peksen, Caghan, Savas, Osman Anil, Chousleb, Elias, Elmokayed, Fahad, Fakhereldin, Islam, Aboshanab, Hany Mohamed, Swelium, Talal, Gudal, Ahmad, Gamloo, Lamees, Ugale, Ayushka, Ugale, Surendra, Boeker, Clara, Reetz, Christian, Hakami, Ibrahim Ali, Mall, Julian, Alexandrou, Andreas, Baili, Efstratia, Bodnar, Zsolt, Maleckas, Almantas, Gudaityte, Rita, Guldogan, Cem Emir, Gundogdu, Emre, Ozmen, Mehmet Mahir, Thakkar, Deepti, Dukkipati, Nandakishore, Shah, Poonam Shashank, Shah, Shashank Subhashchandra, Shah, Simran Shashank, Adil, Md Tanveer, Jambulingam, Periyathambi, Mamidanna, Ravikrishna, Whitelaw, Douglas, Jain, Vigyan, Veetil, Deepa Kizhakke, Wadhawan, Randeep, Torres, Max, Tinoco, Tabata, Leclercq, Wouter, Romeijn, Marleen, van de Pas, Kelly, Alkhazraji, Ali K., Taha, Safwan A., Ustun, Murat, Yigit, Taner, Inam, Aatif, Burhanulhaq, Muhammad, Pazouki, Abdolreza, Eghbali, Foolad, Kermansaravi, Mohammad, Jazi, Amir Hosein Davarpanah, Mahmoudieh, Mohsen, Mogharehabed, Neda, Tsiotos, Gregory, Stamou, Konstantinos, Barrera Rodriguez, Francisco J, Rojas Navarro, Marco A., MOhamed Torres, Omar, Martinez, Sergio Lopez, Tamez, Elda Rocio Maltos, Millan Cornejo, Gustavo A., Flores, Jose Eduardo Garcia, Mohammed, Diya Aldeen, Elfawal, Mohamad Hayssam, Shabbir, Asim, Guowei, Kim, So, Jimmy By, Kaplan, Elif Tuğçe, Kaplan, Mehmet, Kaplan, Tuğba, Pham, DangTuan, Rana, Gurteshwar, Kappus, Mojdeh, Gadani, Riddish, Kahitan, Manish, Pokharel, Koshish, Osborne, Alan, Pournaras, Dimitri, Hewes, James, Napolitano, Errichetta, Chiappetta, Sonja, Bottino, Vincenzo, Dorado, Evelyn, Schoettler, Axel, Gaertner, Daniel, Fedtke, Katharina, Aguilar-Espinosa, Francisco, Aceves-Lozano, Saul, Balani, Alessandro, Nagliati, Carlo, Pennisi, Damiano, Rizzi, Andrea, Frattini, Francesco, Foschi, Diego, Benuzzi, Laura, Parikh, Chirag, Shah, Harshil, Pinotti, Enrico, Montuori, Mauro, Borrelli, Vincenzo, Dargent, Jerome, Copaescu, Catalin A, Hutopila, Ionut, Smeu, Bogdan, Witteman, Bart, Hazebroek, Eric, Deden, Laura, Heusschen, Laura, Okkema, Sietske, Aufenacker, Theo, den Hengst, Willem, Vening, Wouter, van der Burgh, Yonta, Ghazal, Ahmad, Ibrahim, Hamza, Niazi, Mourad, Alkhaffaf, Bilal, Altarawni, Mohammad, Cesana, Giovanni Carlo, Anselmino, Marco, Uccelli, Matteo, Olmi, Stefano, Stier, Christine, Akmanlar, Tahsin, Sonnenberg, Thomas, Schieferbein, Uwe, Marcolini, Alejandro, Awruch, Diego, Vicentin, Marco, de Souza Bastos, Eduardo Lemos, Gregorio, Samuel Azenha, Ahuja, Anmol, Mittal, Tarun, Bolckmans, Roel, Wiggins, Tom, Baratte, Clément, Wisnewsky, Judith Aron, Genser, Laurent, Chong, Lynn, Taylor, Lillian, Ward, Salena, Hi, Michael W., Heneghan, Helen, Fearon, Naomi, Plamper, Andreas, Rheinwalt, Karl, Geoghegan, Justin, Ng, Kin Cheung, Kaseja, Krzysztof, Kotowski, Maciej, Samarkandy, Tarig A., Leyva-Alvizo, Adolfo, Corzo-Culebro, Lourdes, Wang, Cunchuan, Yang, Wah, Dong, Zhiyong, Riera, Manel, Jain, Rajesh, Hamed, Hosam, Said, Mohammed, Zarzar, Katia, Garcia, Manuel, Türkçapar, Ahmet Gökhan, Şen, Ozan, Baldini, Edoardo, Conti, Luigi, Wietzycoski, Cacio, Lopes, Eduardo, Pintar, Tadeja, Salobir, Jure, Aydin, Cengiz, Atici, Semra Demirli, Ergin, Anıl, Ciyiltepe, Huseyin, Bozkurt, Mehmet Abdussamet, Kizilkaya, Mehmet Celal, Onalan, Nezihe Berrin Dodur, Binti Ahmad Zuber, Mariana Nabila, Wong, Wei Jin, Garcia, Amador, Vidal, Laura, Beisani, Marc, Pasquier, Jorge, Vilallonga, Ramon, Sharma, Sharad, Parmar, Chetan, Lee, Lyndcie, Sufi, Pratik, Sinan, Hüseyin, Saydam, Mehmet, Singhal, Rishi, Omar, Islam, Ludwig, Christian, Tahrani, Abd A., and Mahawar, Kamal
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- 2022
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8. A Specifically Tailored Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver Disease—Related Markers in Patients with Obesity after Mini Gastric Bypass Surgery
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Crommen, Silke, Rheinwalt, Karl Peter, Plamper, Andreas, Simon, Marie-Christine, Rösler, Daniela, Fimmers, Rolf, Egert, Sarah, and Metzner, Christine
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- 2022
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9. Prognostic Characteristics of Metabolic Dysfunction-Associated Steatotic Liver in Patients with Obesity Who Undergo One Anastomosis Gastric Bypass Surgery: A Secondary Analysis of Randomized Controlled Trial Data.
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Crommen, Silke, Rheinwalt, Karl Peter, Plamper, Andreas, Rösler, Daniela, Weinhold, Leonie, Metzner, Christine, and Egert, Sarah
- Abstract
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obesity and insulin resistance (IR). Identifying characteristics that predict a higher risk of fibrosis using noninvasive methods is particularly important. Methods: We performed a secondary analysis of data from an RCT of 48 patients after one anastomosis gastric bypass (OAGB) surgery, supplemented with specifically formulated probiotics and micronutrients or control treatment for 12 weeks. Patients were categorized using alanine aminotransferase (ALAT; >35 U/L for women, >50 U/L for men), higher NAFLD fibrosis score (NFS) > −1.455), and IR (HOMA-IR > 2.0). This trial was registered at Clinicaltrials.gov (ID: NCT03585413). Results: Abnormal ALAT was associated with high triglycerides, blood pressure (BP), glucose, and fatty liver index (FLI). NFS > −1.455 was linked to higher age, body mass, waist circumference, and FLI, and lower albumin and platelet count. HOMA-IR > 2.0 was associated with higher BP and triglycerides, lower HDL-cholesterol, higher serum transaminases, and higher probabilities of steatosis and fibrosis. Twelve weeks postoperatively, patients with NFS > −1.455 showed greater reductions in body mass, systolic BP, serum insulin, and HbA1c, whereas those with NFS ≤ −1.455 showed improvements in FLI and lipid metabolism but had high glucose concentrations. Patients with HOMA-IR ≤ 2.0 also had high glucose concentrations. Conclusions: The evaluation of common biomarker scores for fibrosis and IR may help clinicians to recognize severe NAFLD and improve the outcomes of OAGB surgery. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Impact of sleeve gastrectomy and dietary change on metabolic and hepatic function in an obesity rat model - Experimental research
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Dohmen, Jonas, Praktiknjo, Michael, Rudeloff, Anna, Uschner, Frank Erhard, Klein, Sabine, Plamper, Andreas, Matthaei, Hanno, Rheinwalt, Karl-Peter, Wehner, Sven, Kalff, Jörg C., Trebicka, Jonel, and Lingohr, Philipp
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- 2020
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11. The First Report of One Anastomosis Gastric Bypass in a Patient with Intestinal Malrotation
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Plamper, Andreas, Kakuan, Mana, Conejero, Fabio Russo, Parmar, Chetan, and Rheinwalt, Karl
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- 2021
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12. One Anastomosis Gastric Bypass–Mini-Gastric Bypass (OAGB-MGB) Versus Roux-en-Y Gastric Bypass (RYGB)—a Mid-Term Cohort Study with 612 Patients
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Rheinwalt, Karl P., Plamper, Andreas, Rückbeil, Marcia V., Kroh, Andreas, Neumann, Ulf P., and Ulmer, Tom F.
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- 2020
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13. Banding the Pouch with a Non-adjustable Ring as Revisional Procedure in Patients with Insufficient Results After Roux-en-Y Gastric Bypass: Short-term Outcomes of a Multicenter Cohort Study
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Boerboom, Abel, Aarts, Edo, Lange, Volker, Plamper, Andreas, Rheinwalt, Karl, Linke, Katja, Peterli, Ralph, Berends, Frits, and Hazebroek, Eric
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- 2020
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14. The Ideal Length of Jejunal Limb in MGB
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Rheinwalt, Karl Peter, Plamper, Andreas, and Deitel, Mervyn, editor
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- 2018
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15. Potential danger to patients due to European new regulation also in obesity surgery
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Rheinwalt, Karl Peter, primary and Plamper, Andreas, additional
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- 2023
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16. Development of a novel non-invasive test for prediction of liver fibrosis in patients with clinically severe obesity defined by a BMI over 50 kg/m²
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Brol, Maximilian Joseph, primary, Drebber, Uta, additional, Yu, Xiaojie, additional, Schierwagen, Robert, additional, Klein, Sabine, additional, Plamper, Andreas, additional, Odenthal, Margarete, additional, Gu, Wenyi, additional, Uschner, Frank Erhard, additional, Rheinwalt, Karl-Peter, additional, and Trebicka, Jonel, additional
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- 2023
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17. Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery
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Brol, MaximilianJoseph, additional, Drebber, Uta, additional, Yu, Xiaojie, additional, Schierwagen, Robert, additional, Gu, Wenyi, additional, Plamper, Andreas, additional, Klein, Sabine, additional, Odenthal, Margarete, additional, Uschner, FrankErhard, additional, Praktiknjo, Michael, additional, Trebicka, Jonel, additional, and Rheinwalt, KarlPeter, additional
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- 2023
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18. Comparison of mini-gastric bypass with sleeve gastrectomy in a mainly super-obese patient group: first results
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Plamper, Andreas, Lingohr, Philipp, Nadal, Jennifer, and Rheinwalt, Karl P.
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- 2017
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19. Health-related Quality-of-life outcomes following Roux-en-Y-Gastric-Bypass versus One-Anastomosis- Gastric-Bypass
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Rheinwalt, Karl Peter, primary, Fobbe, Anna, additional, Plamper, Andreas, additional, Alizai, Patrick Hamid, additional, Schmitz, Sophia Marie-Therese, additional, Brol, Maximilian Joseph, additional, Trebicka, Jonel, additional, Neumann, Ulf Peter, additional, and Ulmer, Tom Florian, additional
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- 2022
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20. Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study
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Singhal, Rishi, primary, Omar, Islam, additional, Madhok, Brijesh, additional, Ludwig, Christian, additional, Tahrani, Abd A., additional, Mahawar, Kamal, additional, Pędziwiatr, Michał, additional, Major, Piotr, additional, Zarzycki, Piotr, additional, Pantelis, Athanasios, additional, Lapatsanis, Dimitris P., additional, Stravodimos, Georgios, additional, Matthys, Chris, additional, Focquet, Marc, additional, Vleeschouwers, Wouter, additional, Spaventa, Antonio G., additional, Zerrweck, Carlos, additional, Vitiello, Antonio, additional, Berardi, Giovanna, additional, Musella, Mario, additional, Sanchez-Meza, Alberto, additional, Cantu, Felipe J., additional, Mora, Fernando, additional, Cantu, Marco A., additional, Katakwar, Abhishek, additional, Reddy, D. Nageshwar, additional, Elmaleh, Haitham, additional, Hassan, Mohammad, additional, Elghandour, Abdelrahman, additional, Elbanna, Mohey, additional, Osman, Ahmed, additional, Khan, Athar, additional, Layani, Laurent, additional, Kiran, Nalini, additional, Velikorechin, Andrey, additional, Solovyeva, Maria, additional, Melali, Hamid, additional, Shahabi, Shahab, additional, Agrawal, Ashish, additional, Shrivastava, Apoorv, additional, Sharma, Ankur, additional, Narwaria, Bhavya, additional, Narwaria, Mahendra, additional, Raziel, Asnat, additional, Sakran, Nasser, additional, Susmallian, Sergio, additional, Karagöz, Levent, additional, Akbaba, Murat, additional, Pişkin, Salih Zeki, additional, Balta, Ahmet Ziya, additional, Senol, Zafer, additional, Manno, Emilio, additional, Iovino, Michele Giuseppe, additional, Qassem, Mohamed, additional, Arana-Garza, Sebastián, additional, Povoas, Heitor P., additional, Vilas-Boas, Marcos Leão, additional, Li, Alan, additional, Ammori, Basil J., additional, Balamoun, Hany, additional, Salman, Mohammed, additional, Nasta, Amrit Manik, additional, Goel, Ramen, additional, Sánchez-Aguilar, Hugo, additional, Herrera, Miguel F., additional, Abou-Mrad, Adel, additional, Cloix, Lucie, additional, Mazzini, Guilherme Silva, additional, Kristem, Leonardo, additional, Lazaro, Andre, additional, Campos, Jose, additional, Bernardo, Joaquín, additional, González, Jesús, additional, Trindade, Carlos, additional, Viveiros, Octávio, additional, Ribeiro, Rui, additional, Goitein, David, additional, Hazzan, David, additional, Segev, Lior, additional, Beck, Tamar, additional, Reyes, Hernán, additional, Monterrubio, Jerónimo, additional, García, Paulina, additional, Benois, Marine, additional, Kassir, Radwan, additional, Contine, Alessandro, additional, Elshafei, Moustafa, additional, Aktas, Sueleyman, additional, Weiner, Sylvia, additional, Heidsieck, Till, additional, Level, Luis, additional, Pinango, Silvia, additional, Ortega, Patricia Martinez, additional, Moncada, Rafael, additional, Valenti, Victor, additional, Vlahović, Ivan, additional, Boras, Zdenko, additional, Liagre, Arnaud, additional, Martini, Francesco, additional, Juglard, Gildas, additional, Motwani, Manish, additional, Saggu, Sukhvinder Singh, additional, Momani, Hazem Al, additional, López, Luis Adolfo Aceves, additional, Cortez, María Angelina Contreras, additional, Zavala, Rodrigo Aceves, additional, D'Haese, Christine, additional, Kempeneers, Ivo, additional, Himpens, Jacques, additional, Lazzati, Andrea, additional, Paolino, Luca, additional, Bathaei, Sarah, additional, Bedirli, Abdulkadir, additional, Yavuz, Aydın, additional, Büyükkasap, Çağrı, additional, Özaydın, Safa, additional, Kwiatkowski, Andrzej, additional, Bartosiak, Katarzyna, additional, Walędziak, Maciej, additional, Santonicola, Antonella, additional, Angrisani, Luigi, additional, Iovino, Paola, additional, Palma, Rossella, additional, Iossa, Angelo, additional, Boru, Cristian Eugeniu, additional, Angelis, Francesco De, additional, Silecchia, Gianfranco, additional, Hussain, Abdulzahra, additional, Balchandra, Srivinasan, additional, Coltell, Izaskun Balciscueta, additional, Pérez, Javier Lorenzo, additional, Bohra, Ashok, additional, Awan, Altaf K., additional, Leeder, Paul C., additional, Awad, Sherif, additional, Al-Khyatt, Waleed, additional, Shoma, Ashraf, additional, Elghadban, Hosam, additional, Ghareeb, Sameh, additional, Mathews, Bryan, additional, Kurian, Marina, additional, Larentzakis, Andreas, additional, Vrakopoulou, Gavriella Zoi, additional, Albanopoulos, Konstantinos, additional, Bozdag, Ahemt, additional, Lale, Azmi, additional, Kirkil, Cuneyt, additional, Dincer, Mursid, additional, Bashir, Ahmad, additional, Haddad, Ashraf, additional, Hijleh, Leen Abu, additional, Zilberstein, Bruno, additional, de Marchi, Danilo Dallago, additional, Souza, Willy Petrini, additional, Brodén, Carl Magnus, additional, Gislason, Hjörtur, additional, Shah, Kamran, additional, Ambrosi, Antonio, additional, Pavone, Giovanna, additional, Tartaglia, Nicola, additional, Kumari Kona, S. Lakshmi, additional, Kalyan, K., additional, Perez, Cesar Ernesto Guevara, additional, Botero, Miguel Alberto Forero, additional, Covic, Adrian, additional, Timofte, Daniel, additional, Maxim, Madalina, additional, Faraj, Dashti, additional, Tseng, Larissa, additional, Liem, Ronald, additional, Ören, Gürdal, additional, Dilektasli, Evren, additional, Yalcin, Ilker, additional, AlMukhtar, Hudhaifa, additional, Hadad, Mohammed Al, additional, Mohan, Rasmi, additional, Arora, Naresh, additional, Bedi, Digvijaysingh, additional, Rives-Lange, Claire, additional, Chevallier, Jean-Marc, additional, Poghosyan, Tigran, additional, Sebbag, Hugues, additional, Zinaï, Lamia, additional, Khaldi, Saadi, additional, Mauchien, Charles, additional, Mazza, Davide, additional, Dinescu, Georgiana, additional, Rea, Bernardo, additional, Pérez-Galaz, Fernando, additional, Zavala, Luis, additional, Besa, Anais, additional, Curell, Anna, additional, Balibrea, Jose M., additional, Vaz, Carlos, additional, Galindo, Luis, additional, Silva, Nelson, additional, Caballero, José Luis Estrada, additional, Sebastian, Sergio Ortiz, additional, Marchesini, João Caetano Dallegrave, additional, da Fonseca Pereira, Ricardo Arcanjo, additional, Sobottka, Wagner Herbert, additional, Fiolo, Felipe Eduardo, additional, Turchi, Matias, additional, Coelho, Antonio Claudio Jamel, additional, Zacaron, Andre Luis, additional, Barbosa, André, additional, Quinino, Reynaldo, additional, Menaldi, Gabriel, additional, Paleari, Nicolás, additional, Martinez-Duartez, Pedro, additional, de Aragon Ramírez de Esparza, Gabriel Martínez, additional, Esteban, Valentin Sierra, additional, Torres, Antonio, additional, Garcia-Galocha, Jose Luis, additional, Josa, Miguel, additional, Pacheco-Garcia, Jose Manuel, additional, Mayo-Ossorio, Maria Angeles, additional, Chowbey, Pradeep, additional, Soni, Vandana, additional, de Vasconcelos Cunha, Hercio Azevedo, additional, Castilho, Michel Victor, additional, Ferreira, Rafael Meneguzzi Alves, additional, Barreiro, Thiago Alvim, additional, Charalabopoulos, Alexandros, additional, Sdralis, Elias, additional, Davakis, Spyridon, additional, Bomans, Benoit, additional, Dapri, Giovanni, additional, Belle, Koenraad Van, additional, Takieddine, Mazen, additional, Vaneukem, Pol, additional, Karaca, Esma Seda Akalın, additional, Karaca, Fatih Can, additional, Sumer, Aziz, additional, Peksen, Caghan, additional, Savas, Osman Anil, additional, Chousleb, Elias, additional, Elmokayed, Fahad, additional, Fakhereldin, Islam, additional, Aboshanab, Hany Mohamed, additional, Swelium, Talal, additional, Gudal, Ahmad, additional, Gamloo, Lamees, additional, Ugale, Ayushka, additional, Ugale, Surendra, additional, Boeker, Clara, additional, Reetz, Christian, additional, Hakami, Ibrahim Ali, additional, Mall, Julian, additional, Alexandrou, Andreas, additional, Baili, Efstratia, additional, Bodnar, Zsolt, additional, Maleckas, Almantas, additional, Gudaityte, Rita, additional, Guldogan, Cem Emir, additional, Gundogdu, Emre, additional, Ozmen, Mehmet Mahir, additional, Thakkar, Deepti, additional, Dukkipati, Nandakishore, additional, Shah, Poonam Shashank, additional, Shah, Shashank Subhashchandra, additional, Shah, Simran Shashank, additional, Adil, Md Tanveer, additional, Jambulingam, Periyathambi, additional, Mamidanna, Ravikrishna, additional, Whitelaw, Douglas, additional, Jain, Vigyan, additional, Veetil, Deepa Kizhakke, additional, Wadhawan, Randeep, additional, Torres, Max, additional, Tinoco, Tabata, additional, Leclercq, Wouter, additional, Romeijn, Marleen, additional, van de Pas, Kelly, additional, Alkhazraji, Ali K., additional, Taha, Safwan A., additional, Ustun, Murat, additional, Yigit, Taner, additional, Inam, Aatif, additional, Burhanulhaq, Muhammad, additional, Pazouki, Abdolreza, additional, Eghbali, Foolad, additional, Kermansaravi, Mohammad, additional, Jazi, Amir Hosein Davarpanah, additional, Mahmoudieh, Mohsen, additional, Mogharehabed, Neda, additional, Tsiotos, Gregory, additional, Stamou, Konstantinos, additional, Barrera Rodriguez, Francisco J, additional, Rojas Navarro, Marco A., additional, MOhamed Torres, Omar, additional, Martinez, Sergio Lopez, additional, Tamez, Elda Rocio Maltos, additional, Millan Cornejo, Gustavo A., additional, Flores, Jose Eduardo Garcia, additional, Mohammed, Diya Aldeen, additional, Elfawal, Mohamad Hayssam, additional, Shabbir, Asim, additional, Guowei, Kim, additional, So, Jimmy By, additional, Kaplan, Elif Tuğçe, additional, Kaplan, Mehmet, additional, Kaplan, Tuğba, additional, Pham, DangTuan, additional, Rana, Gurteshwar, additional, Kappus, Mojdeh, additional, Gadani, Riddish, additional, Kahitan, Manish, additional, Pokharel, Koshish, additional, Osborne, Alan, additional, Pournaras, Dimitri, additional, Hewes, James, additional, Napolitano, Errichetta, additional, Chiappetta, Sonja, additional, Bottino, Vincenzo, additional, Dorado, Evelyn, additional, Schoettler, Axel, additional, Gaertner, Daniel, additional, Fedtke, Katharina, additional, Aguilar-Espinosa, Francisco, additional, Aceves-Lozano, Saul, additional, Balani, Alessandro, additional, Nagliati, Carlo, additional, Pennisi, Damiano, additional, Rizzi, Andrea, additional, Frattini, Francesco, additional, Foschi, Diego, additional, Benuzzi, Laura, additional, Parikh, Chirag, additional, Shah, Harshil, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Borrelli, Vincenzo, additional, Dargent, Jerome, additional, Copaescu, Catalin A, additional, Hutopila, Ionut, additional, Smeu, Bogdan, additional, Witteman, Bart, additional, Hazebroek, Eric, additional, Deden, Laura, additional, Heusschen, Laura, additional, Okkema, Sietske, additional, Aufenacker, Theo, additional, den Hengst, Willem, additional, Vening, Wouter, additional, van der Burgh, Yonta, additional, Ghazal, Ahmad, additional, Ibrahim, Hamza, additional, Niazi, Mourad, additional, Alkhaffaf, Bilal, additional, Altarawni, Mohammad, additional, Cesana, Giovanni Carlo, additional, Anselmino, Marco, additional, Uccelli, Matteo, additional, Olmi, Stefano, additional, Stier, Christine, additional, Akmanlar, Tahsin, additional, Sonnenberg, Thomas, additional, Schieferbein, Uwe, additional, Marcolini, Alejandro, additional, Awruch, Diego, additional, Vicentin, Marco, additional, de Souza Bastos, Eduardo Lemos, additional, Gregorio, Samuel Azenha, additional, Ahuja, Anmol, additional, Mittal, Tarun, additional, Bolckmans, Roel, additional, Wiggins, Tom, additional, Baratte, Clément, additional, Wisnewsky, Judith Aron, additional, Genser, Laurent, additional, Chong, Lynn, additional, Taylor, Lillian, additional, Ward, Salena, additional, Hi, Michael W., additional, Heneghan, Helen, additional, Fearon, Naomi, additional, Plamper, Andreas, additional, Rheinwalt, Karl, additional, Geoghegan, Justin, additional, Ng, Kin Cheung, additional, Kaseja, Krzysztof, additional, Kotowski, Maciej, additional, Samarkandy, Tarig A., additional, Leyva-Alvizo, Adolfo, additional, Corzo-Culebro, Lourdes, additional, Wang, Cunchuan, additional, Yang, Wah, additional, Dong, Zhiyong, additional, Riera, Manel, additional, Jain, Rajesh, additional, Hamed, Hosam, additional, Said, Mohammed, additional, Zarzar, Katia, additional, Garcia, Manuel, additional, Türkçapar, Ahmet Gökhan, additional, Şen, Ozan, additional, Baldini, Edoardo, additional, Conti, Luigi, additional, Wietzycoski, Cacio, additional, Lopes, Eduardo, additional, Pintar, Tadeja, additional, Salobir, Jure, additional, Aydin, Cengiz, additional, Atici, Semra Demirli, additional, Ergin, Anıl, additional, Ciyiltepe, Huseyin, additional, Bozkurt, Mehmet Abdussamet, additional, Kizilkaya, Mehmet Celal, additional, Onalan, Nezihe Berrin Dodur, additional, Binti Ahmad Zuber, Mariana Nabila, additional, Wong, Wei Jin, additional, Garcia, Amador, additional, Vidal, Laura, additional, Beisani, Marc, additional, Pasquier, Jorge, additional, Vilallonga, Ramon, additional, Sharma, Sharad, additional, Parmar, Chetan, additional, Lee, Lyndcie, additional, Sufi, Pratik, additional, Sinan, Hüseyin, additional, and Saydam, Mehmet, additional
- Published
- 2022
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21. Reply to IFSO Worldwide Survey 2014
- Author
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Deitel, Mervyn, Rheinwalt, Karl Peter, Plamper, Andreas, Weiner, Rudolf, Chiappetta, Sonja, Cady, Jean, Soprani, Antoine, Luciani, Roger Charles, Carbajo, Miguel A., and Musella, Mario
- Published
- 2018
- Full Text
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22. Clinical outcomes after one anastomosis gastric bypass versus sleeve gastrectomy in super-super-obese patients
- Author
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Schmitz, Sophia M.-T., primary, Alizai, Patrick H., additional, Kroh, Andreas, additional, Schipper, Sandra, additional, Brozat, Jonathan F., additional, Plamper, Andreas, additional, Neumann, Ulf P., additional, Rheinwalt, Karl, additional, and Ulmer, Tom F., additional
- Published
- 2021
- Full Text
- View/download PDF
23. Letter to the Editor: Bariatric Surgery and Endoluminal Procedures: IFSO Worldwide Survey 2014
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Plamper, Andreas, Deitel, Mervyn, and Rheinwalt, Karl P.
- Published
- 2017
- Full Text
- View/download PDF
24. The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease
- Author
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Schierwagen, Robert, Uschner, Frank E., Ortiz, Cristina, Torres, Sandra, Brol, Max J., Tyc, Olaf, Gu, Wenyi, Grimm, Christian, Zeuzem, Stefan, Plamper, Andreas, Pfeifer, Philipp, Zimmer, Sebastian, Welsch, Christoph, Schaefer, Liliana, Rheinwalt, Karl P., Clària i Enrich, Joan, Arroyo, Vicente, Trebicka, Jonel, Klein, Sabine, and Mandrekar, Pranoti
- Subjects
Liver Cirrhosis ,Immunology ,Severity of Illness Index ,Cystic fibrosis ,Mice ,ACLF ,Animals ,Humans ,Immunology and Allergy ,bacterial translocation ,Lectins, C-Type ,ddc:610 ,Liver diseases ,Original Research ,Mice, Knockout ,Inflammation ,Gene Expression Profiling ,Liver Diseases ,Macrophages ,Malalties del fetge ,fibrosis ,NASH ,Fibrosi quística ,Inflamació ,Disease Models, Animal ,Gene Expression Regulation ,inflammation ,Disease Susceptibility ,Transcriptome ,Biomarkers - Abstract
The macrophage-inducible C-type lectin (mincle) is part of the innate immune system and acts as a pattern recognition receptor for pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPs). Ligand binding induces mincle activation which consequently interacts with the signaling adapter Fc receptor, SYK, and NF-kappa-B. There is also evidence that mincle expressed on macrophages promotes intestinal barrier integrity. However, little is known about the role of mincle in hepatic fibrosis, especially in more advanced disease stages. Mincle expression was measured in human liver samples from cirrhotic patients and donors collected at liver transplantation and in patients undergoing bariatric surgery. Human results were confirmed in rodent models of cirrhosis and acute-on-chronic liver failure (ACLF). In these models, the role of mincle was investigated in liver samples as well as in peripheral blood monocytes (PBMC), tissues from the kidney, spleen, small intestine, and heart. Additionally, mincle activation was stimulated in experimental non-alcoholic steatohepatitis (NASH) by treatment with mincle agonist trehalose-6,6-dibehenate (TDB). In human NASH, mincle is upregulated with increased collagen production. In ApoE deficient mice fed high-fat western diet (NASH model), mincle activation significantly increases hepatic collagen production. In human cirrhosis, mincle expression is also significantly upregulated. Furthermore, mincle expression is associated with the stage of chronic liver disease. This could be confirmed in rat models of cirrhosis and ACLF. ACLF was induced by LPS injection in cirrhotic rats. While mincle expression and downstream signaling via FC receptor gamma, SYK, and NF-kappa-B are upregulated in the liver, they are downregulated in PBMCs of these rats. Although mincle expressed on macrophages might be beneficial for intestinal barrier integrity, it seems to contribute to inflammation and fibrosis once the intestinal barrier becomes leaky in advanced stages of chronic liver disease.
- Published
- 2020
- Full Text
- View/download PDF
25. Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
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Rheinwalt, Karl Peter, Drebber, Uta, Schierwagen, Robert, Klein, Sabine, Neumann, Ulf Peter, Ulmer, Tom Florian, Plamper, Andreas, Kroh, Andreas, Schipper, Sandra, Odenthal, Margarete, Uschner, Frank Erhard, Lingohr, Philipp, Trebicka, Jonel, Brol, Maximilian Joseph, Rheinwalt, Karl Peter, Drebber, Uta, Schierwagen, Robert, Klein, Sabine, Neumann, Ulf Peter, Ulmer, Tom Florian, Plamper, Andreas, Kroh, Andreas, Schipper, Sandra, Odenthal, Margarete, Uschner, Frank Erhard, Lingohr, Philipp, Trebicka, Jonel, and Brol, Maximilian Joseph
- Abstract
Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients' weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to No NAFLD, NAFL or NASH. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m(2) vs. 36.8 kg/m(2) and 36.1 kg/m(2), 12 months: 27.0 kg/m(2) vs. 34.4 and 32.8 kg/m(2)) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%; 12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.
- Published
- 2020
26. The role of macrophage-inducible c-type lectin in different stages of chronic liver disease
- Author
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Mandrekar, Pranoti, Schierwagen, Robert, Uschner, Frank Erhard, Ortiz, Cristina, Torres Núñez, Sandra, Brol, Maximilian, Tyc, Olaf, Gu, Wenyi, Grimm, Christian, Zeuzem, Stefan, Plamper, Andreas, Pfeifer, Philipp, Zimmer, Sebastian, Welsch, Christoph, Schäfer, Liliana, Rheinwalt, Karl P., Clària, Joan, Arroyo, Vicente, Trebicka, Jonel, Klein, Sabine, Mandrekar, Pranoti, Schierwagen, Robert, Uschner, Frank Erhard, Ortiz, Cristina, Torres Núñez, Sandra, Brol, Maximilian, Tyc, Olaf, Gu, Wenyi, Grimm, Christian, Zeuzem, Stefan, Plamper, Andreas, Pfeifer, Philipp, Zimmer, Sebastian, Welsch, Christoph, Schäfer, Liliana, Rheinwalt, Karl P., Clària, Joan, Arroyo, Vicente, Trebicka, Jonel, and Klein, Sabine
- Abstract
The macrophage-inducible C-type lectin (mincle) is part of the innate immune system and acts as a pattern recognition receptor for pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPs). Ligand binding induces mincle activation which consequently interacts with the signaling adapter Fc receptor, SYK, and NF-kappa-B. There is also evidence that mincle expressed on macrophages promotes intestinal barrier integrity. However, little is known about the role of mincle in hepatic fibrosis, especially in more advanced disease stages. Mincle expression was measured in human liver samples from cirrhotic patients and donors collected at liver transplantation and in patients undergoing bariatric surgery. Human results were confirmed in rodent models of cirrhosis and acute-on-chronic liver failure (ACLF). In these models, the role of mincle was investigated in liver samples as well as in peripheral blood monocytes (PBMC), tissues from the kidney, spleen, small intestine, and heart. Additionally, mincle activation was stimulated in experimental non-alcoholic steatohepatitis (NASH) by treatment with mincle agonist trehalose-6,6-dibehenate (TDB). In human NASH, mincle is upregulated with increased collagen production. In ApoE deficient mice fed high-fat western diet (NASH model), mincle activation significantly increases hepatic collagen production. In human cirrhosis, mincle expression is also significantly upregulated. Furthermore, mincle expression is associated with the stage of chronic liver disease. This could be confirmed in rat models of cirrhosis and ACLF. ACLF was induced by LPS injection in cirrhotic rats. While mincle expression and downstream signaling via FC receptor gamma, SYK, and NF-kappa-B are upregulated in the liver, they are downregulated in PBMCs of these rats. Although mincle expressed on macrophages might be beneficial for intestinal barrier integrity, it seems to contribute to inflammation and fibrosis once the intes
- Published
- 2020
27. SAT-492 - Development of a novel non-invasive test for prediction of liver fibrosis in patients with clinically severe obesity defined by a BMI over 50 kg/m²
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Brol, Maximilian Joseph, Drebber, Uta, Yu, Xiaojie, Schierwagen, Robert, Klein, Sabine, Plamper, Andreas, Odenthal, Margarete, Gu, Wenyi, Uschner, Frank Erhard, Rheinwalt, Karl-Peter, and Trebicka, Jonel
- Published
- 2023
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- View/download PDF
28. Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
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Rheinwalt, Karl Peter, primary, Drebber, Uta, additional, Schierwagen, Robert, additional, Klein, Sabine, additional, Neumann, Ulf Peter, additional, Ulmer, Tom Florian, additional, Plamper, Andreas, additional, Kroh, Andreas, additional, Schipper, Sandra, additional, Odenthal, Margarete, additional, Uschner, Frank Erhard, additional, Lingohr, Philipp, additional, Trebicka, Jonel, additional, and Brol, Maximilian Joseph, additional
- Published
- 2020
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- View/download PDF
29. Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis
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Brol, Maximilian Joseph, Roesch, Felicitas, Schierwagen, Robert, Magdaleno, Fernando, Uschner, Frank Erhard, Manekeller, Steffen, Queck, Alexander, Schwarzkopf, Katharina, Odenthal, Margarete, Drebber, Uta, Thiele, Maja, Lingohr, Philipp, Plamper, Andreas, Kristiansen, Glen, Lotersztajn, Sophie, Krag, Aleksander, Klein, Sabine, Rheinwalt, Karl P., Trebicka, Jonel, Brol, Maximilian Joseph, Roesch, Felicitas, Schierwagen, Robert, Magdaleno, Fernando, Uschner, Frank Erhard, Manekeller, Steffen, Queck, Alexander, Schwarzkopf, Katharina, Odenthal, Margarete, Drebber, Uta, Thiele, Maja, Lingohr, Philipp, Plamper, Andreas, Kristiansen, Glen, Lotersztajn, Sophie, Krag, Aleksander, Klein, Sabine, Rheinwalt, Karl P., and Trebicka, Jonel
- Abstract
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or alcoholic (ALD) fatty liver disease, respectively. In particular, presence of fibrosis in (NAFLD) and (ALD) requires treatment, but development of drugs is hampered by the lack of suitable models with significant fibrosis. The carbon tetrachloride (CCl4) liver fibrosis model does not reflect human NAFLD or ALD, but CCl4 may serve as a fibrosis accelerator in addition to another injury. Ethanol in drinking water (16%) or Western diet (WD) were administered for 7 wk in mice either alone or in combination with CCl4 intoxications. Extent of fibrosis. steatosis, and inflammation was assessed by histology, transcription, and biochemistry. Furthermore, transcription of fibrosis, proliferation, and inflammation-related genes was studied on human liver samples with fibrosis resulting from hepatitis C virus infection (n = 7), NAFLD (n = 8), or ALD (n = 7). WD or ethanol alone induced only mild steatosis and inflammation. Combination of CCl4 and WD induced the most severe steatosis together with significant liver fibrosis and moderate inflammation. Combination of CCl4 and ethanol induced the strongest inflammation, with significant liver fibrosis and moderate steatosis. The relationship pattern between fibrosis, proliferation, and inflammation of human ALD was mostly similar in mice treated with CCl4 and ethanol. The combination of CCl4 intoxication with WD validates previous data suggesting it as an appropriate model for human nonalcoholic steato-hepatitis. Especially, CCl4 plus ethanol for 7 wk induces ALD in mice, providing a model suitable for further basic research and drug testing. NEW & NOTEWORTHY Alcoholic fatty liver disease with significant fibrosis is generated within 7 wk using carbon tetrachloride as a fibrosis accelerator and administering gradually ethanol (up to 16%) in mice. The similarity in the pattern of steatosis, inflammation, and fibrosis involved in alcoholic fatty liver disease to
- Published
- 2019
30. One Anastomosis Gastric Bypass–Mini-Gastric Bypass (OAGB-MGB) Versus Roux-en-Y Gastric Bypass (RYGB)—a Mid-Term Cohort Study with 612 Patients
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Rheinwalt, Karl P., primary, Plamper, Andreas, additional, Rückbeil, Marcia V., additional, Kroh, Andreas, additional, Neumann, Ulf P., additional, and Ulmer, Tom F., additional
- Published
- 2019
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- View/download PDF
31. Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis
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Brol, Maximilian Joseph, primary, Rösch, Felicitas, additional, Schierwagen, Robert, additional, Magdaleno, Fernando, additional, Uschner, Frank Erhard, additional, Manekeller, Steffen, additional, Queck, Alexander, additional, Schwarzkopf, Katharina, additional, Odenthal, Margarete, additional, Drebber, Uta, additional, Thiele, Maja, additional, Lingohr, Philipp, additional, Plamper, Andreas, additional, Kristiansen, Glen, additional, Lotersztajn, Sophie, additional, Krag, Aleksander, additional, Klein, Sabine, additional, Rheinwalt, Karl P., additional, and Trebicka, Jonel, additional
- Published
- 2019
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32. First Case of Laparoscopic Mini-Gastric Bypass for the Treatment of Morbid Obesity in Severe Haemophilia A
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Plamper, Andreas, additional, Goldmann, Georg, additional, Lingohr, Philipp, additional, Horneff, Silvia, additional, Dohmen, Jonas, additional, Oldenburg, Johannes, additional, and Rheinwalt, Karl P., additional
- Published
- 2018
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- View/download PDF
33. Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis.
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Brol, Maximilian Joseph, Rösch, Felicitas, Schierwagen, Robert, Magdaleno, Fernando, Uschner, Frank Erhard, Manekeller, Steffen, Queck, Alexander, Schwarzkopf, Katharina, Odenthal, Margarete, Drebber, Uta, Thiele, Maja, Lingohr, Philipp, Plamper, Andreas, Kristiansen, Glen, Lotersztajn, Sophie, Krag, Aleksander, Klein, Sabine, Rheinwalt, Karl P., and Trebicka, Jonel
- Subjects
ALCOHOLIC liver diseases ,FATTY liver ,FIBROSIS ,HEPATITIS C virus ,WOUNDS & injuries - Abstract
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or alcoholic (ALD) fatty liver disease, respectively. In particular, presence of fibrosis in NAFLD and ALD requires treatment, but development of drugs is hampered by the lack of suitable models with significant fibrosis. The carbon tetrachloride (CCl
4 ) liver fibrosis model does not reflect human NAFLD or ALD, but CCl4 may serve as a fibrosis accelerator in addition to another injury. Ethanol in drinking water (16%) or Western diet (WD) were administered for 7 wk in mice either alone or in combination with CCl4 intoxications. Extent of fibrosis, steatosis, and inflammation was assessed by histology, transcription, and biochemistry. Furthermore, transcription of fibrosis, proliferation, and inflammation-related genes was studied on human liver samples with fibrosis resulting from hepatitis C virus infection (n = 7), NAFLD (n = 8), or ALD (n = 7). WD or ethanol alone induced only mild steatosis and inflammation. Combination of CCl4 and WD induced the most severe steatosis together with significant liver fibrosis and moderate inflammation. Combination of CCl4 and ethanol induced the strongest inflammation, with significant liver fibrosis and moderate steatosis. The relationship pattern between fibrosis, proliferation, and inflammation of human ALD was mostly similar in mice treated with CCl4 and ethanol. The combination of CCl4 intoxication with WD validates previous data suggesting it as an appropriate model for human nonalcoholic steatohepatitis. Especially, CCl4 plus ethanol for 7 wk induces ALD in mice, providing a model suitable for further basic research and drug testing. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
34. Comparison of mini-gastric bypass with sleeve gastrectomy in a mainly super-obese patient group: first results
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Plamper, Andreas, primary, Lingohr, Philipp, additional, Nadal, Jennifer, additional, and Rheinwalt, Karl P., additional
- Published
- 2016
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35. Comparison of Omega Loop Gastric Bypass Versus Sleeve Gastrectomy In A Mainly Super-Obese Patient Group – Short- and Mid-Term Results
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Plamper, Andreas, primary, Lingohr, Philipp, additional, Nadal Dipl, Jennifer, additional, and Rheinwalt, Karl, additional
- Published
- 2015
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36. First Case of Laparoscopic Mini-Gastric Bypass for the Treatment of Morbid Obesity in Severe Haemophilia A.
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Plamper, Andreas, Goldmann, Georg, Lingohr, Philipp, Horneff, Silvia, Dohmen, Jonas, Oldenburg, Johannes, and Rheinwalt, Karl P.
- Published
- 2019
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37. A5085 - Comparison of Omega Loop Gastric Bypass Versus Sleeve Gastrectomy In A Mainly Super-Obese Patient Group – Short- and Mid-Term Results
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Plamper, Andreas, Lingohr, Philipp, Nadal Dipl, Jennifer, and Rheinwalt, Karl
- Published
- 2015
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38. Letter to the Editor: Bariatric Surgery and Endoluminal Procedures: IFSO Worldwide Survey 2014.
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Plamper, Andreas, Deitel, Mervyn, and Rheinwalt, Karl
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BARIATRIC surgery ,METABOLIC disorders - Published
- 2018
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39. Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity.
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RHEINWALT, KARL PETER, DREBBER, UTA, SCHIERWAGEN, ROBERT, KLEIN, SABINE, NEUMANN, ULF PETER, ULMER, TOM FLORIAN, PLAMPER, ANDREAS, KROH, ANDREAS, SCHIPPER, SANDRA, ODENTHAL, MARGARETE, USCHNER, FRANK ERHARD, LINGOHR, PHILIPP, TREBICKA, JONEL, and BROL, MAXIMILIAN JOSEPH
- Subjects
- *
GASTRIC bypass , *WEIGHT loss , *MORBID obesity , *BARIATRIC surgery , *NON-alcoholic fatty liver disease , *BODY mass index - Abstract
Background: Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients' weight loss. Data about the influence of nonalcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods: This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (one anastomosis-mini gastric bypass [OAGB-MGB] or Roux-en-Y gastric bypass [RYGB]). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to "No NAFLD," "NAFL," or "NASH." Follow-up data were collected at 3, 6, and 12 months. Results: In total, 49.7 percent of patients had NASH, while 41.3 percent had NAFL. Compared to the No NAFLD group, NAFL and NASH showed higher body mass index (BMI) at follow-up (6 months: 31.0kg/m2 vs. 36.8kg/m2 and 36.1kg/m2, 12 months: 27.0kg/m2 vs. 34.4 and 32.8kg/m2) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%; 12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusion: Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after RYGB. The mechanisms underlying this observation should be further studied. [ABSTRACT FROM AUTHOR]
- Published
- 2021
40. 30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries.
- Author
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Singhal R, Ludwig C, Rudge G, Gkoutos GV, Tahrani A, Mahawar K, Pędziwiatr M, Major P, Zarzycki P, Pantelis A, Lapatsanis DP, Stravodimos G, Matthys C, Focquet M, Vleeschouwers W, Spaventa AG, Zerrweck C, Vitiello A, Berardi G, Musella M, Sanchez-Meza A, Cantu FJ Jr, Mora F, Cantu MA, Katakwar A, Reddy DN, Elmaleh H, Hassan M, Elghandour A, Elbanna M, Osman A, Khan A, Layani L, Kiran N, Velikorechin A, Solovyeva M, Melali H, Shahabi S, Agrawal A, Shrivastava A, Sharma A, Narwaria B, Narwaria M, Raziel A, Sakran N, Susmallian S, Karagöz L, Akbaba M, Pişkin SZ, Balta AZ, Senol Z, Manno E, Iovino MG, Osman A, Qassem M, Arana-Garza S, Povoas HP, Vilas-Boas ML, Naumann D, Super J, Li A, Ammori BJ, Balamoun H, Salman M, Nasta AM, Goel R, Sánchez-Aguilar H, Herrera MF, Abou-Mrad A, Cloix L, Mazzini GS, Kristem L, Lazaro A, Campos J, Bernardo J, González J, Trindade C, Viveiros O, Ribeiro R, Goitein D, Hazzan D, Segev L, Beck T, Reyes H, Monterrubio J, García P, Benois M, Kassir R, Contine A, Elshafei M, Aktas S, Weiner S, Heidsieck T, Level L, Pinango S, Ortega PM, Moncada R, Valenti V, Vlahović I, Boras Z, Liagre A, Martini F, Juglard G, Motwani M, Saggu SS, Al Moman H, López LAA, Cortez MAC, Zavala RA, D'Haese C, Kempeneers I, Himpens J, Lazzati A, Paolino L, Bathaei S, Bedirli A, Yavuz A, Büyükkasap Ç, Özaydın S, Kwiatkowski A, Bartosiak K, Walędziak M, Santonicola A, Angrisani L, Iovino P, Palma R, Iossa A, Boru CE, De Angelis F, Silecchia G, Hussain A, Balchandra S, Coltell IB, Pérez JL, Bohra A, Awan AK, Madhok B, Leeder PC, Awad S, Al-Khyatt W, Shoma A, Elghadban H, Ghareeb S, Mathews B, Kurian M, Larentzakis A, Vrakopoulou GZ, Albanopoulos K, Bozdag A, Lale A, Kirkil C, Dincer M, Bashir A, Haddad A, Hijleh LA, Zilberstein B, de Marchi DD, Souza WP, Brodén CM, Gislason H, Shah K, Ambrosi A, Pavone G, Tartaglia N, Kona SLK, Kalyan K, Perez CEG, Botero MAF, Covic A, Timofte D, Maxim M, Faraj D, Tseng L, Liem R, Ören G, Dilektasli E, Yalcin I, AlMukhtar H, Al Hadad M, Mohan R, Arora N, Bedi D, Rives-Lange C, Chevallier JM, Poghosyan T, Sebbag H, Zinaï L, Khaldi S, Mauchien C, Mazza D, Dinescu G, Rea B, Pérez-Galaz F, Zavala L, Besa A, Curell A, Balibrea JM, Vaz C, Galindo L, Silva N, Caballero JLE, Sebastian SO, Marchesini JCD, da Fonseca Pereira RA, Sobottka WH, Fiolo FE, Turchi M, Coelho ACJ, Zacaron AL, Barbosa A, Quinino R, Menaldi G, Paleari N, Martinez-Duartez P, de Aragon Ramírez de Esparza GM, Esteban VS, Torres A, Garcia-Galocha JL, Josa M, Pacheco-Garcia JM, Mayo-Ossorio MA, Chowbey P, Soni V, de Vasconcelos Cunha HA, Castilho MV, Ferreira RMA, Barreiro TA, Charalabopoulos A, Sdralis E, Davakis S, Bomans B, Dapri G, Van Belle K, Takieddine M, Vaneukem P, Karaca ESA, Karaca FC, Sumer A, Peksen C, Savas OA, Chousleb E, Elmokayed F, Fakhereldin I, Aboshanab HM, Swelium T, Gudal A, Gamloo L, Ugale A, Ugale S, Boeker C, Reetz C, Hakami IA, Mall J, Alexandrou A, Baili E, Bodnar Z, Maleckas A, Gudaityte R, Guldogan CE, Gundogdu E, Ozmen MM, Thakkar D, Dukkipati N, Shah PS, Shah SS, Shah SS, Adil MT, Jambulingam P, Mamidanna R, Whitelaw D, Adil MT, Jain V, Veetil DK, Wadhawan R, Torres A, Torres M, Tinoco T, Leclercq W, Romeijn M, van de Pas K, Alkhazraji AK, Taha SA, Ustun M, Yigit T, Inam A, Burhanulhaq M, Pazouki A, Eghbali F, Kermansaravi M, Jazi AHD, Mahmoudieh M, Mogharehabed N, Tsiotos G, Stamou K, Barrera Rodriguez FJ, Rojas Navarro MA, Torres OM, Martinez SL, Tamez ERM, Millan Cornejo GA, Flores JEG, Mohammed DA, Elfawal MH, Shabbir A, Guowei K, So JB, Kaplan ET, Kaplan M, Kaplan T, Pham D, Rana G, Kappus M, Gadani R, Kahitan M, Pokharel K, Osborne A, Pournaras D, Hewes J, Napolitano E, Chiappetta S, Bottino V, Dorado E, Schoettler A, Gaertner D, Fedtke K, Aguilar-Espinosa F, Aceves-Lozano S, Balani A, Nagliati C, Pennisi D, Rizzi A, Frattini F, Foschi D, Benuzzi L, Parikh C, Shah H, Pinotti E, Montuori M, Borrelli V, Dargent J, Copaescu CA, Hutopila I, Smeu B, Witteman B, Hazebroek E, Deden L, Heusschen L, Okkema S, Aufenacker T, den Hengst W, Vening W, van der Burgh Y, Ghazal A, Ibrahim H, Niazi M, Alkhaffaf B, Altarawni M, Cesana GC, Anselmino M, Uccelli M, Olmi S, Stier C, Akmanlar T, Sonnenberg T, Schieferbein U, Marcolini A, Awruch D, Vicentin M, de Souza Bastos EL, Gregorio SA, Ahuja A, Mittal T, Bolckmans R, Wiggins T, Baratte C, Wisnewsky JA, Genser L, Chong L, Taylor L, Ward S, Chong L, Taylor L, Hi MW, Heneghan H, Fearon N, Plamper A, Rheinwalt K, Heneghan H, Geoghegan J, Ng KC, Fearon N, Kaseja K, Kotowski M, Samarkandy TA, Leyva-Alvizo A, Corzo-Culebro L, Wang C, Yang W, Dong Z, Riera M, Jain R, Hamed H, Said M, Zarzar K, Garcia M, Türkçapar AG, Şen O, Baldini E, Conti L, Wietzycoski C, Lopes E, Pintar T, Salobir J, Aydin C, Atici SD, Ergin A, Ciyiltepe H, Bozkurt MA, Kizilkaya MC, Onalan NBD, Zuber MNBA, Wong WJ, Garcia A, Vidal L, Beisani M, Pasquier J, Vilallonga R, Sharma S, Parmar C, Lee L, Sufi P, Sinan H, and Saydam M
- Subjects
- COVID-19 Testing, Cohort Studies, Humans, Incidence, Pandemics, Postoperative Complications epidemiology, SARS-CoV-2, Bariatric Surgery, COVID-19, Diabetes Mellitus, Type 2, Obesity, Morbid surgery
- Abstract
Background: There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates., Methods: We conducted an international cohort study to determine all-cause and COVID-19-specific 30-day morbidity and mortality of BS performed between 01/05/2020 and 31/10/2020., Results: Four hundred ninety-nine surgeons from 185 centres in 42 countries provided data on 7704 patients. Elective primary BS (n = 7084) was associated with a 30-day morbidity of 6.76% (n = 479) and a 30-day mortality of 0.14% (n = 10). Emergency BS, revisional BS, insulin-treated type 2 diabetes, and untreated obstructive sleep apnoea were associated with increased complications on multivariable analysis. Forty-three patients developed symptomatic COVID-19 postoperatively, with a higher risk in non-whites. Preoperative self-isolation, preoperative testing for SARS-CoV-2, and surgery in institutions not concurrently treating COVID-19 patients did not reduce the incidence of postoperative COVID-19. Postoperative symptomatic COVID-19 was more likely if the surgery was performed during a COVID-19 peak in that country., Conclusions: BS can be performed safely during the COVID-19 pandemic with appropriate perioperative protocols. There was no relationship between preoperative testing for COVID-19 and self-isolation with symptomatic postoperative COVID-19. The risk of postoperative COVID-19 risk was greater in non-whites or if BS was performed during a local peak., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
41. Combination of CCl 4 with alcoholic and metabolic injuries mimics human liver fibrosis.
- Author
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Brol MJ, Rösch F, Schierwagen R, Magdaleno F, Uschner FE, Manekeller S, Queck A, Schwarzkopf K, Odenthal M, Drebber U, Thiele M, Lingohr P, Plamper A, Kristiansen G, Lotersztajn S, Krag A, Klein S, Rheinwalt KP, and Trebicka J
- Subjects
- Animals, Disease Models, Animal, Humans, Inflammation metabolism, Mice, Solvents metabolism, Solvents toxicity, Carbon Tetrachloride metabolism, Carbon Tetrachloride toxicity, Ethanol metabolism, Fatty Liver chemically induced, Fatty Liver metabolism, Fatty Liver, Alcoholic etiology, Fatty Liver, Alcoholic metabolism, Liver Cirrhosis chemically induced, Liver Cirrhosis metabolism
- Abstract
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or alcoholic (ALD) fatty liver disease, respectively. In particular, presence of fibrosis in NAFLD and ALD requires treatment, but development of drugs is hampered by the lack of suitable models with significant fibrosis. The carbon tetrachloride (CCl
4 ) liver fibrosis model does not reflect human NAFLD or ALD, but CCl4 may serve as a fibrosis accelerator in addition to another injury. Ethanol in drinking water (16%) or Western diet (WD) were administered for 7 wk in mice either alone or in combination with CCl4 intoxications. Extent of fibrosis, steatosis, and inflammation was assessed by histology, transcription, and biochemistry. Furthermore, transcription of fibrosis, proliferation, and inflammation-related genes was studied on human liver samples with fibrosis resulting from hepatitis C virus infection ( n = 7), NAFLD ( n = 8), or ALD ( n = 7). WD or ethanol alone induced only mild steatosis and inflammation. Combination of CCl4 and WD induced the most severe steatosis together with significant liver fibrosis and moderate inflammation. Combination of CCl4 and ethanol induced the strongest inflammation, with significant liver fibrosis and moderate steatosis. The relationship pattern between fibrosis, proliferation, and inflammation of human ALD was mostly similar in mice treated with CCl4 and ethanol. The combination of CCl4 intoxication with WD validates previous data suggesting it as an appropriate model for human nonalcoholic steatohepatitis. Especially, CCl4 plus ethanol for 7 wk induces ALD in mice, providing a model suitable for further basic research and drug testing. NEW & NOTEWORTHY Alcoholic fatty liver disease with significant fibrosis is generated within 7 wk using carbon tetrachloride as a fibrosis accelerator and administering gradually ethanol (up to 16%) in mice. The similarity in the pattern of steatosis, inflammation, and fibrosis involved in alcoholic fatty liver disease to those of the human condition renders this mouse model suitable as a preclinical model for drug development.- Published
- 2019
- Full Text
- View/download PDF
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